                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  MULTISPECIFIC TRANSTHYRETIN IMMUNOGLOBULIN FUSIONS

<130>  A-2414-WO-PCT

<150>  62/871,247
<151>  2019-07-08

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TTR AA

<400>  1

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  2
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine TTR AA

<400>  2

Gly Pro Ala Gly Ala Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val Ala Val Lys Val 
            20                  25                  30          


Phe Lys Lys Thr Ser Glu Gly Ser Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr Asp Glu Lys Phe 
    50                  55                  60                  


Val Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Thr Leu Gly Ile Ser Pro Phe His Glu Phe Ala Asp Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn Pro Gln Asn 
        115                 120                 125         


<210>  3
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine TTR NA

<400>  3
acagaagtcc actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg       60

ctggactggt atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc      120

tgatggtcaa agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg      180

tgttcagaaa ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt      240

ctggagagct gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg      300

aaatagacac caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag      360

aggtggtatt cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga      420

gcccctactc ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc      480

ctccagtgga cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt      540

actaaagcac tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac      600

attcctgtga aaggc                                                       615


<210>  4
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP 3B1 Ab LC AA

<400>  4

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  5
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Ab LC NA

<400>  5
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctga aggagacaga      120

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcag      180

aaaccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccattaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt ctacagtata atagttaccc gtggacgttc      360

ggccaaggga ccaaggtgga aatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  6
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP 3B1 Ab LC AA w/CPM S230E (EU S176E)

<400>  6

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  7
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP 3B1 Ab LC NA w/CPM S230E (EU S176E)

<400>  7
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctga aggagacaga      120

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcag      180

aaaccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccattaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt ctacagtata atagttaccc gtggacgttc      360

ggccaaggga ccaaggtgga aatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cgaaagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  8
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP 3B1 Ab HC AA

<400>  8

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  9
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP 3B1 Ab HC NA

<400>  9
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctgca ggagtcgggc ccaggactgg ttaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagtagtt actactggag ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gaacaccaac      240

tccaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagaacc      360

tactatgata gtagtggtta ctactaccgt gcttttgata tctggggcca agggacaatg      420

gtcaccgtct ctagtgcctc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gt                        1422


<210>  10
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Ab HC AA

w/CPM S230K (EU S183K)

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  11
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Ab HC NA w/CPM S230K (EU S183K)

<400>  11
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctgca ggagtcgggc ccaggactgg ttaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagtagtt actactggag ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gaacaccaac      240

tccaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagaacc      360

tactatgata gtagtggtta ctactaccgt gcttttgata tctggggcca agggacaatg      420

gtcaccgtct ctagtgcctc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc aagagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gt                        1422


<210>  12
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Fab HC AA

<400>  12

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys 
                245             


<210>  13
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Fab HC AA

<400>  13
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctgca ggagtcgggc ccaggactgg ttaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagtagtt actactggag ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gaacaccaac      240

tccaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagaacc      360

tactatgata gtagtggtta ctactaccgt gcttttgata tctggggcca agggacaatg      420

gtcaccgtct ctagtgcctc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgt                                             744


<210>  14
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Fab HC AA w/CPM S230K (EU S183K)

<400>  14

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys 
                245             


<210>  15
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Fab HC NA w/CPM S230K (EU S183K)

<400>  15
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctgca ggagtcgggc ccaggactgg ttaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagtagtt actactggag ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gaacaccaac      240

tccaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagaacc      360

tactatgata gtagtggtta ctactaccgt gcttttgata tctggggcca agggacaatg      420

gtcaccgtct ctagtgcctc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc aagagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgt                                             744


<210>  16
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC AA

<400>  16

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Arg Ser Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Ser Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  17
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC NA

<400>  17
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gggtattagt agaagcgaat tagcctggta ccagcagaaa      180

cctggccagg ctcccagcct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcaa caatttggta gttcaccgtg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gctagcgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  18
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC AA w/CPM S230K (EU S176K)

<400>  18

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Arg Ser Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Ser Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Lys Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  19
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC NA w/CPM S230K (EU S176K)

<400>  19
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gggtattagt agaagcgaat tagcctggta ccagcagaaa      180

cctggccagg ctcccagcct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcaa caatttggta gttcaccgtg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gctagcgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcaa gagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  20
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Ab HC AA

<400>  20

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Ala Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  21
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Ab HC NA

<400>  21
atgaagcacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgattact tctggagctg gatccgccag      180

ctcccaggga agggcctgga gtggattggg cacatccata acagtgggac cacctactac      240

aatccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa gcagttctcc      300

ctgaggctga gttctgtgac tgccgcggac acggccgtat attactgtgc gagagatcga      360

gggggtgact acgcttatgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      420

tcagcctcca ccaagggccc atccgtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt                                      1410


<210>  22
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Ab HC AA w/CPM S230E (EU S183E)

<400>  22

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Ala Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  23
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Ab HC NA w/CPM S230E (EU S183E)

<400>  23
atgaagcacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgattact tctggagctg gatccgccag      180

ctcccaggga agggcctgga gtggattggg cacatccata acagtgggac cacctactac      240

aatccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa gcagttctcc      300

ctgaggctga gttctgtgac tgccgcggac acggccgtat attactgtgc gagagatcga      360

gggggtgact acgcttatgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      420

tcagcctcca ccaagggccc atccgtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcga gagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt                                      1410


<210>  24
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Fab HC AA

<400>  24

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Ala Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys 
                


<210>  25
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Fab HC NA

<400>  25
atgaagcacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgattact tctggagctg gatccgccag      180

ctcccaggga agggcctgga gtggattggg cacatccata acagtgggac cacctactac      240

aatccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa gcagttctcc      300

ctgaggctga gttctgtgac tgccgcggac acggccgtat attactgtgc gagagatcga      360

gggggtgact acgcttatgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      420

tcagcctcca ccaagggccc atccgtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gt                                                          732


<210>  26
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Fab HC AA w/CPM S230E (EU S183E)

<400>  26

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Ala Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys 
                


<210>  27
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Fab HC NA w/CPM S230E (EU S183E)

<400>  27
atgaagcacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgattact tctggagctg gatccgccag      180

ctcccaggga agggcctgga gtggattggg cacatccata acagtgggac cacctactac      240

aatccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa gcagttctcc      300

ctgaggctga gttctgtgac tgccgcggac acggccgtat attactgtgc gagagatcga      360

gggggtgact acgcttatgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      420

tcagcctcca ccaagggccc atccgtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcga gagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gt                                                          732


<210>  28
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Ab LC NA (TTR construct)

<400>  28
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctga aggagacaga      120

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcag      180

aaaccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccattaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt ctacagtata atagttaccc gtggacgttc      360

ggccaaggga ccaaggtgga aatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  29
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Ab LC AA (TTR construct)

<400>  29

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  30
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Ab HC NA (TTR construct)

<400>  30
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctgca ggagtcgggc ccaggactgg ttaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagtagtt actactggag ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gaacaccaac      240

tccaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagaacc      360

tactatgata gtagtggtta ctactaccgt gcttttgata tctggggcca agggacaatg      420

gtcaccgtct ctagtgcctc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtggaggcgg tccaactggt     1440

actggtgaat ctaaagctcc tcttatggtt gcagtcaaag atgctgttcg tggttccccg     1500

gcaattaatg ttgctgtaca tgttttccgt aaagctgctg acgacacctg ggaaccgttc     1560

gctagcggta aaacctccga atccggtgaa ctgcacggtc tgaccaccga agaagaattc     1620

gttgaaggta tctacaaagt tgaaatcgac accaaatcct actggaaagc tttgggtatc     1680

tccccgttcc acgaacacgc tgaagttgtt ttcaccgcta acgactccgg tccgcgtcgt     1740

tacacgatcg ctgctctgct gtccccgtac tcctactcca ccaccgctgt tgttaccaac     1800

ccgaaagaa                                                             1809


<210>  31
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Ab LC AA (TTR construct)

<400>  31

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Pro Thr Gly 
465                 470                 475                 480 


Thr Gly Glu Ser Lys Ala Pro Leu Met Val Ala Val Lys Asp Ala Val 
                485                 490                 495     


Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val Phe Arg Lys Ala 
            500                 505                 510         


Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys Thr Ser Glu Ser 
        515                 520                 525             


Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe Val Glu Gly Ile 
    530                 535                 540                 


Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys Ala Leu Gly Ile 
545                 550                 555                 560 


Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr Ala Asn Asp Ser 
                565                 570                 575     


Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr 
            580                 585                 590         


Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        595                 600             


<210>  32
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC NA (TTR construct)

<400>  32
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gggtattagt agaagcgaat tagcctggta ccagcagaaa      180

cctggccagg ctcccagcct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcaa caatttggta gttcaccgtg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gctagcgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  33
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC AA (TTR construct)

<400>  33

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Arg Ser Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Ser Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  34
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Ab HC NA (TTR construct)

<400>  34
atgaagcacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgattact tctggagctg gatccgccag      180

ctcccaggga agggcctgga gtggattggg cacatccata acagtgggac cacctactac      240

aatccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa gcagttctcc      300

ctgaggctga gttctgtgac tgccgcggac acggccgtat attactgtgc gagagatcga      360

gggggtgact acgcttatgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      420

tcagcctcca ccaagggccc atccgtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt ggaggcggtc caactggtac tggtgaatct     1440

aaagctcctc ttatggttgc agtcgatgat gctgttcgtg gttccccggc aattaatgtt     1500

gctgtacatg ttttccgtaa agctgctgac gacacctggg aaccgttcgc tagcggtaaa     1560

acctccgaat ccggtgaact gcacggtctg accaccgaag aagaattcgt tgaaggtatc     1620

tacaaagttg aaatcgacac caaatcctac tggaaagctt tgggtatctc cccgttccac     1680

gaacacgctg aagttgtttt caccgctaac gactccggtc cgcgtcgtta cacgatcgct     1740

gctctgctgt ccccgtactc ctactccacc accgctgttg ttaccaaccc gaaagaa        1797


<210>  35
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Ab LC AA (TTR construct)

<400>  35

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Ala Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Gly Gly Gly Pro Thr Gly Thr Gly Glu Ser 
465                 470                 475                 480 


Lys Ala Pro Leu Met Val Ala Val Asp Asp Ala Val Arg Gly Ser Pro 
                485                 490                 495     


Ala Ile Asn Val Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr 
            500                 505                 510         


Trp Glu Pro Phe Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His 
        515                 520                 525             


Gly Leu Thr Thr Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu 
    530                 535                 540                 


Ile Asp Thr Lys Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His 
545                 550                 555                 560 


Glu His Ala Glu Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg 
                565                 570                 575     


Tyr Thr Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala 
            580                 585                 590         


Val Val Thr Asn Pro Lys Glu 
        595                 


<210>  36
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Fab LC NA (TTR construct)

<400>  36
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gggtattagt agaagcgaat tagcctggta ccagcagaaa      180

cctggccagg ctcccagcct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcaa caatttggta gttcaccgtg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gctagcgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  37
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Fab LC AA (TTR construct)

<400>  37

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Arg Ser Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Ser Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  38
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  655-341 Fab HC NA (TTR construct)

<400>  38
atgaagcacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgattact tctggagctg gatccgccag      180

ctcccaggga agggcctgga gtggattggg cacatccata acagtgggac cacctactac      240

aatccgtccc tcaagagtcg agttaccata tcagtagaca cgtctaagaa gcagttctcc      300

ctgaggctga gttctgtgac tgccgcggac acggccgtat attactgtgc gagagatcga      360

gggggtgact acgcttatgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      420

tcagcctcca ccaagggccc atccgtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gtggaggagg tccaactggt actggtgaat ctaaagctcc tcttatggtt      780

gcagtcgatg atgctgttcg tggttccccg gcaattaatg ttgctgtaca tgttttccgt      840

aaagctgctg acgacacctg ggaaccgttc gctagcggta aaacctccga atccggtgaa      900

ctgcacggtc tgaccaccga agaagaattc gttgaaggta tctacaaagt tgaaatcgac      960

accaaatcct actggaaagc tttgggtatc tccccgttcc acgaacacgc tgaagttgtt     1020

ttcaccgcta acgactccgg tccgcgtcgt tacacgatcg ctgctctgct gtccccgtac     1080

tcctactcca ccaccgctgt tgttaccaac ccgaaagaag gcggtcacca tcaccatcac     1140

cac                                                                   1143


<210>  39
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  655-341 Fab HC AA (TTR construct)

<400>  39

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Ala Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Gly Gly Gly Pro Thr Gly Thr Gly Glu Ser Lys Ala 
                245                 250                 255     


Pro Leu Met Val Ala Val Asp Asp Ala Val Arg Gly Ser Pro Ala Ile 
            260                 265                 270         


Asn Val Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu 
        275                 280                 285             


Pro Phe Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu 
    290                 295                 300                 


Thr Thr Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp 
305                 310                 315                 320 


Thr Lys Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His 
                325                 330                 335     


Ala Glu Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr 
            340                 345                 350         


Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val 
        355                 360                 365             


Thr Asn Pro Lys Glu Gly Gly His His His His His His 
    370                 375                 380     


<210>  40
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNP Fab LC NA (TTR construct)

<400>  40
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctga aggagacaga      120

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcag      180

aaaccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccattaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt ctacagtata atagttaccc gtggacgttc      360

ggccaaggga ccaaggtgga aatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  41
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Fab LC AA (TTR construct)

<400>  41

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  42
<211>  1155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Fab HC NA (TTR construct)

<400>  42

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Gly Gly Thr Gly Cys 
1               5                   10                  15      


Cys Cys Gly Cys Thr Cys Ala Gly Cys Thr Cys Cys Thr Gly Gly Gly 
            20                  25                  30          


Gly Cys Thr Cys Cys Thr Gly Cys Thr Gly Cys Thr Gly Thr Gly Gly 
        35                  40                  45              


Cys Thr Gly Ala Gly Ala Gly Gly Thr Gly Cys Gly Cys Gly Cys Thr 
    50                  55                  60                  


Gly Thr Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala 
65                  70                  75                  80  


Gly Gly Ala Gly Thr Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala 
                85                  90                  95      


Cys Thr Gly Gly Thr Thr Ala Ala Gly Cys Cys Thr Thr Cys Gly Gly 
            100                 105                 110         


Ala Gly Ala Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys 
        115                 120                 125             


Cys Thr Gly Cys Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Thr 
    130                 135                 140                 


Gly Gly Cys Thr Cys Cys Ala Thr Cys Ala Gly Thr Ala Gly Thr Thr 
145                 150                 155                 160 


Ala Cys Thr Ala Cys Thr Gly Gly Ala Gly Cys Thr Gly Gly Ala Thr 
                165                 170                 175     


Cys Cys Gly Gly Cys Ala Gly Cys Cys Cys Cys Cys Ala Gly Gly Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Ala Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala 
        195                 200                 205             


Thr Thr Gly Gly Gly Thr Ala Thr Ala Thr Cys Thr Ala Thr Thr Ala 
    210                 215                 220                 


Cys Ala Gly Thr Gly Gly Gly Ala Ala Cys Ala Cys Cys Ala Ala Cys 
225                 230                 235                 240 


Thr Cys Cys Ala Ala Cys Cys Cys Cys Thr Cys Cys Cys Thr Cys Ala 
                245                 250                 255     


Ala Gly Ala Gly Thr Cys Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr 
            260                 265                 270         


Ala Thr Cys Ala Gly Thr Ala Gly Ala Cys Ala Cys Gly Thr Cys Cys 
        275                 280                 285             


Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Thr Cys Thr Cys Cys Cys 
    290                 295                 300                 


Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly Cys Thr Cys Thr Gly Thr 
305                 310                 315                 320 


Gly Ala Cys Cys Gly Cys Thr Gly Cys Gly Gly Ala Cys Ala Cys Gly 
                325                 330                 335     


Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly 
            340                 345                 350         


Cys Gly Ala Gly Ala Ala Cys Cys Thr Ala Cys Thr Ala Thr Gly Ala 
        355                 360                 365             


Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Thr Ala Cys Thr Ala Cys 
    370                 375                 380                 


Thr Ala Cys Cys Gly Thr Gly Cys Thr Thr Thr Thr Gly Ala Thr Ala 
385                 390                 395                 400 


Thr Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys 
                405                 410                 415     


Ala Ala Thr Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Thr 
            420                 425                 430         


Ala Gly Thr Gly Cys Cys Thr Cys Cys Ala Cys Cys Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Cys Ala Thr Cys Gly Gly Thr Cys Thr Thr Cys Cys Cys 
    450                 455                 460                 


Cys Cys Thr Gly Gly Cys Ala Cys Cys Cys Thr Cys Cys Thr Cys Cys 
465                 470                 475                 480 


Ala Ala Gly Ala Gly Cys Ala Cys Cys Thr Cys Thr Gly Gly Gly Gly 
                485                 490                 495     


Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Cys Cys Thr Gly Gly Gly 
            500                 505                 510         


Cys Thr Gly Cys Cys Thr Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys 
        515                 520                 525             


Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Ala Cys Cys Gly Gly 
    530                 535                 540                 


Thr Gly Ala Cys Gly Gly Thr Gly Thr Cys Gly Thr Gly Gly Ala Ala 
545                 550                 555                 560 


Cys Thr Cys Ala Gly Gly Cys Gly Cys Cys Cys Thr Gly Ala Cys Cys 
                565                 570                 575     


Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr 
            580                 585                 590         


Thr Cys Cys Cys Gly Gly Cys Thr Gly Thr Cys Cys Thr Ala Cys Ala 
        595                 600                 605             


Gly Thr Cys Cys Thr Cys Ala Gly Gly Ala Cys Thr Cys Thr Ala Cys 
    610                 615                 620                 


Thr Cys Cys Cys Thr Cys Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly 
625                 630                 635                 640 


Thr Gly Ala Cys Cys Gly Thr Gly Cys Cys Cys Thr Cys Cys Ala Gly 
                645                 650                 655     


Cys Ala Gly Cys Thr Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly 
            660                 665                 670         


Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly 
        675                 680                 685             


Thr Gly Ala Ala Thr Cys Ala Cys Ala Ala Gly Cys Cys Cys Ala Gly 
    690                 695                 700                 


Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys 
705                 710                 715                 720 


Ala Ala Gly Ala Ala Ala Gly Thr Thr Gly Ala Gly Cys Cys Cys Ala 
                725                 730                 735     


Ala Ala Thr Cys Thr Thr Gly Thr Gly Gly Ala Gly Gly Ala Gly Gly 
            740                 745                 750         


Thr Cys Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Thr Gly Gly Thr 
        755                 760                 765             


Gly Ala Ala Thr Cys Thr Ala Ala Ala Gly Cys Thr Cys Cys Thr Cys 
    770                 775                 780                 


Thr Thr Ala Thr Gly Gly Thr Thr Gly Cys Ala Gly Thr Cys Ala Ala 
785                 790                 795                 800 


Ala Gly Ala Thr Gly Cys Thr Gly Thr Thr Cys Gly Thr Gly Gly Thr 
                805                 810                 815     


Thr Cys Cys Cys Cys Gly Gly Cys Ala Ala Thr Thr Ala Ala Thr Gly 
            820                 825                 830         


Thr Thr Gly Cys Thr Gly Thr Ala Cys Ala Thr Gly Thr Thr Thr Thr 
        835                 840                 845             


Cys Cys Gly Thr Ala Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Cys 
    850                 855                 860                 


Gly Ala Cys Ala Cys Cys Thr Gly Gly Gly Ala Ala Cys Cys Gly Thr 
865                 870                 875                 880 


Thr Cys Gly Cys Thr Ala Gly Cys Gly Gly Thr Ala Ala Ala Ala Cys 
                885                 890                 895     


Cys Thr Cys Cys Gly Ala Ala Thr Cys Cys Gly Gly Thr Gly Ala Ala 
            900                 905                 910         


Cys Thr Gly Cys Ala Cys Gly Gly Thr Cys Thr Gly Ala Cys Cys Ala 
        915                 920                 925             


Cys Cys Gly Ala Ala Gly Ala Ala Gly Ala Ala Thr Thr Cys Gly Thr 
    930                 935                 940                 


Thr Gly Ala Ala Gly Gly Thr Ala Thr Cys Thr Ala Cys Ala Ala Ala 
945                 950                 955                 960 


Gly Thr Thr Gly Ala Ala Ala Thr Cys Gly Ala Cys Ala Cys Cys Ala 
                965                 970                 975     


Ala Ala Thr Cys Cys Thr Ala Cys Thr Gly Gly Ala Ala Ala Gly Cys 
            980                 985                 990         


Thr Thr Thr Gly Gly Gly Thr Ala  Thr Cys Thr Cys Cys  Cys Cys Gly 
        995                 1000                 1005             


Thr Thr  Cys Cys Ala Cys Gly  Ala Ala Cys Ala Cys  Gly Cys Thr 
    1010                 1015                 1020             


Gly Ala  Ala Gly Thr Thr Gly  Thr Thr Thr Thr Cys  Ala Cys Cys 
    1025                 1030                 1035             


Gly Cys  Thr Ala Ala Cys Gly  Ala Cys Thr Cys Cys  Gly Gly Thr 
    1040                 1045                 1050             


Cys Cys  Gly Cys Gly Thr Cys  Gly Thr Thr Ala Cys  Ala Cys Gly 
    1055                 1060                 1065             


Ala Thr  Cys Gly Cys Thr Gly  Cys Thr Cys Thr Gly  Cys Thr Gly 
    1070                 1075                 1080             


Thr Cys  Cys Cys Cys Gly Thr  Ala Cys Thr Cys Cys  Thr Ala Cys 
    1085                 1090                 1095             


Thr Cys  Cys Ala Cys Cys Ala  Cys Cys Gly Cys Thr  Gly Thr Thr 
    1100                 1105                 1110             


Gly Thr  Thr Ala Cys Cys Ala  Ala Cys Cys Cys Gly  Ala Ala Ala 
    1115                 1120                 1125             


Gly Ala  Ala Gly Gly Cys Gly  Gly Thr Cys Ala Cys  Cys Ala Thr 
    1130                 1135                 1140             


Cys Ala  Cys Cys Ala Thr Cys  Ala Cys Cys Ala Cys  
    1145                 1150                 1155 


<210>  43
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNP Fab HC AA (TTR construct)

<400>  43

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Thr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
        115                 120                 125             


Tyr Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Pro Thr Gly Thr Gly 
                245                 250                 255     


Glu Ser Lys Ala Pro Leu Met Val Ala Val Lys Asp Ala Val Arg Gly 
            260                 265                 270         


Ser Pro Ala Ile Asn Val Ala Val His Val Phe Arg Lys Ala Ala Asp 
        275                 280                 285             


Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu 
    290                 295                 300                 


Leu His Gly Leu Thr Thr Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys 
305                 310                 315                 320 


Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro 
                325                 330                 335     


Phe His Glu His Ala Glu Val Val Phe Thr Ala Asn Asp Ser Gly Pro 
            340                 345                 350         


Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr 
        355                 360                 365             


Thr Ala Val Val Thr Asn Pro Lys Glu Gly Gly His His His His His 
    370                 375                 380                 


His 
385 


<210>  44
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human TTR NA

<400>  44
ggtccaactg gtaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc       60

cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc      120

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      180

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      240

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      300

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      360

gtcgtcacca atcccaagga a                                                381


