                         SEQUENCE LISTING

<110>  KAHR Medical Ltd.
       Thomas Jefferson University
       TYKOCINSKY, Mark L.
       TAMIR, Ami
       BREMER, Edwin
 
<120>  HETERODIMERS AND METHODS OF USE THEREOF

<130>  82913

<150>  US 62/872,741
<151>  2019-07-11

<160>  166   

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  aa sequence of full length PD1

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  2
<211>  867
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence of full length PD1

<400>  2
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  3
<211>  150
<212>  PRT
<213>  Artificial sequence

<220>
<223>  sequence of PD1 ECD Full with CYS93>Ser substitution

<400>  3

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  4
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 3

<400>  4
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactctc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgctg gccagtttca gacactcgtg                                       450


<210>  5
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 ECM KNOWN FRAGMENT

<400>  5

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln 
                165         


<210>  6
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 ECM KNOWN FRAGMENT

<400>  6

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  7
<211>  150
<212>  PRT
<213>  Artificial sequence

<220>
<223>  150 aa ORIGINAL PD1 DOMAIN

<400>  7

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  8
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na pf SEQ ID NO 7

<400>  8
ccaggatggt tcttagactc tccagatagg ccttggaatc cccctacctt tagccccgcc       60

ctgctggtgg tgacagaggg cgataacgcc accttcacat gctcttttag caacacctcc      120

gagtctttcg tgctgaattg gtacaggatg agcccttcca accagacaga caagctggca      180

gcatttcctg aggaccgctc ccagccaggc caggattgcc ggttcagagt gacccagctg      240

ccaaatggca gggactttca catgagcgtg gtgcgcgccc ggagaaacga ttccggcaca      300

tacctgtgcg gagcaatctc tctggcacca aaggcacaga tcaaggagtc cctgagggca      360

gagctgaggg tgaccgagag gagggccgag gtgccaacag cacacccatc tcctagccca      420

aggccagcag gacagttcca aaccctggtg                                       450


<210>  9
<211>  150
<212>  PRT
<213>  Artificial sequence

<220>
<223>  150 aa ORIGINAL PD1 DOMAIN with CYS93>Ser substitution

<400>  9

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  10
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 9

<400>  10
ccaggatggt tcttagactc tccagatagg ccttggaatc cccctacctt tagccccgcc       60

ctgctggtgg tgacagaggg cgataacgcc accttcacat gctcttttag caacacctcc      120

gagtctttcg tgctgaattg gtacaggatg agcccttcca accagacaga caagctggca      180

gcatttcctg aggaccgctc ccagccaggc caggattctc ggttcagagt gacccagctg      240

ccaaatggca gggactttca catgagcgtg gtgcgcgccc ggagaaacga ttccggcaca      300

tacctgtgcg gagcaatctc tctggcacca aaggcacaga tcaaggagtc cctgagggca      360

gagctgaggg tgaccgagag gagggccgag gtgccaacag cacacccatc tcctagccca      420

aggccagcag gacagttcca aaccctggtg                                       450


<210>  11
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  140 aa -5-5 in PD1 DOMAIN

<400>  11

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140 


<210>  12
<211>  419
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 11

<400>  12
gactctccag ataggccttg gaatccccct acctttagcc ccgccctgct ggtggtgaca       60

gagggcgata acgccacctt cacatgctct tttagcaaca cctccgagtc tttcgtgctg      120

aattggtaca ggatgagccc ttccaaccag acagacaagc tggcagcatt tcctgaggac      180

cgctcccagc caggccagga ttgccggttc agagtgaccc agctgccaaa tggcagggac      240

tttcacatga gcgtggtgcg cgcccggaga aacgattccg gcacatacct gtgcggagca      300

atctctctgg caccaaaggc acagatcaag gagtccctga gggcagagct gagggtgacc      360

gagaggaggg ccgaggtgcc aacagcacac ccatctccta gcccaaggcc agcaggaca       419


<210>  13
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  140 aa -5-5 in PD1 DOMAIN with CYS93>Ser substitution

<400>  13

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140 


<210>  14
<211>  419
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 13

<400>  14
gactctccag ataggccttg gaatccccct acctttagcc ccgccctgct ggtggtgaca       60

gagggcgata acgccacctt cacatgctct tttagcaaca cctccgagtc tttcgtgctg      120

aattggtaca ggatgagccc ttccaaccag acagacaagc tggcagcatt tcctgaggac      180

cgctcccagc caggccagga tctccggttc agagtgaccc agctgccaaa tggcagggac      240

tttcacatga gcgtggtgcg cgcccggaga aacgattccg gcacatacct gtgcggagca      300

atctctctgg caccaaaggc acagatcaag gagtccctga gggcagagct gagggtgacc      360

gagaggaggg ccgaggtgcc aacagcacac ccatctccta gcccaaggcc agcaggaca       419


<210>  15
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  140 aa PD1 segment

<400>  15

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140 


<210>  16
<211>  420
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 15

<400>  16
gactcccctg acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgccggccag      420


<210>  17
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  128 aa PD1 segment

<400>  17

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


<210>  18
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 17

<400>  18
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acct                                             384


<210>  19
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  135 aa PD1 segment

<400>  19

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln 
    130                 135 


<210>  20
<211>  405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 19

<400>  20
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgccg gccag                      405


<210>  21
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  133 aa PD1 segment

<400>  21

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro 
    130             


<210>  22
<211>  399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 21

<400>  22
gactcccctg acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacct                             399


<210>  23
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -10-5 (with CYS93>Ser substitution)

<400>  23

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln 
    130                 135 


<210>  24
<211>  405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 23

<400>  24
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactctc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgctg gccag                      405


<210>  25
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -10-12 (with CYS93>Ser substitution)

<400>  25

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


<210>  26
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 25

<400>  26
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactctc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acct                                             384


<210>  27
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-12 (New, from V20) (with CYS93>Ser substitution)

<400>  27

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro 
    130             


<210>  28
<211>  399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 27

<400>  28
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacct                             399


<210>  29
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-12

<400>  29

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125         


<210>  30
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 29

<400>  30
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactgtcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc t                                                381


<210>  31
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-12 (New, from V18) (with CYS93>Ser substitution)

<400>  31

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125         


<210>  32
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 31

<400>  32
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactctcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc t                                                381


<210>  33
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-5

<400>  33

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro Arg Pro Ala Gly Gln 
    130                 


<210>  34
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 33

<400>  34
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactgtcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc ttctccaaga cctgctggcc ag                         402


<210>  35
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-5 (New, from V19) (with CYS93>Ser substitution)

<400>  35

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro Arg Pro Ala Gly Gln 
    130                 


<210>  36
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 35

<400>  36
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactctcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc ttctccaaga cctgctggcc ag                         402


<210>  37
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-7

<400>  37

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135             


<210>  38
<211>  414
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 37

<400>  38
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgct            414


<210>  39
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-7 (New, from V21) (with CYS93>Ser substitution)

<400>  39

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135             


<210>  40
<211>  414
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 39

<400>  40
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgct            414


<210>  41
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-9 from (with out CYS93>Ser substitution)136 aa

<400>  41

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg 
    130                 135     


<210>  42
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 41

<400>  42
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaaga                   408


<210>  43
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -0-5 from (with out CYS93>Ser substitution)145 aa

<400>  43

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln 
145 


<210>  44
<211>  435
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 43

<400>  44
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactgtc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgctg gccag                                                       435


<210>  45
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -0-7 from (with out CYS93>Ser substitution) 143 aa

<400>  45

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140             


<210>  46
<211>  429
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 45

<400>  46
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactgtc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgct                                                              429


<210>  47
<211>  254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  aa sequence of full length 41BBL

<400>  47

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  48
<211>  765
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence of full length 41BBL

<400>  48
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg      120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc      180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                      765


<210>  49
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL 41BBL DOMAIN

<400>  49

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  50
<211>  615
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 49

<400>  50
gcctgcccct gggccgtgtc cggggctcgc gcctcgcccg gctccgcggc cagcccgaga       60

ctccgcgagg gtcccgagct ttcgcccgac gatcccgccg gcctcttgga cctgcggcag      120

ggcatgtttg cgcagctggt ggcccaaaat gttctgctga tcgatgggcc cctgagctgg      180

tacagtgacc caggcctggc aggcgtgtcc ctgacggggg gcctgagcta caaagaggac      240

acgaaggagc tggtggtggc caaggctgga gtctactatg tcttctttca actagagctg      300

cggcgcgtgg tggccggcga gggctcaggc tccgtttcac ttgcgctgca cctgcagcca      360

ctgcgctctg ctgctggggc cgccgccctg gctttgaccg tggacctgcc acccgcctcc      420

tccgaggctc ggaactcggc cttcggtttc cagggccgct tgctgcacct gagtgccggc      480

cagcgcctgg gcgtccatct tcacactgag gccagggcac gccatgcctg gcagcttacc      540

cagggcgcca cagtcttggg actcttccgg gtgacccccg aaatcccagc cggactccct      600

tcaccgaggt cggaa                                                       615


<210>  51
<211>  191
<212>  PRT
<213>  Artificial sequence

<220>
<223>  191 aa 14-0 in 4-1BBL DOMAIN

<400>  51

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185                 190     


<210>  52
<211>  573
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 51

<400>  52
agcgccgcct cccccaggct gcgcgaggga cctgagctgt ccccagacga tcctgccggc       60

ctgctggacc tgagacaggg aatgtttgcc cagctggtcg ctcagaacgt gctgctgatt      120

gacggccccc tgtcctggta tagcgatcct ggactggcag gcgtgtctct gacaggcgga      180

ctgagttaca aagaagacac taaagaactg gtcgtcgcca aagccggcgt gtactacgtg      240

ttcttccaac tggagctgag gagggtcgtc gccggcgaag gcagcggctc tgtgagcctg      300

gccctgcacc tgcaaccact gaggagcgcc gccggcgccg ccgccctggc cctgactgtg      360

gacctgccac cagcatcctc tgaggcaagg aattccgcct tcggcttcca gggccggctg      420

ctgcacctgt ctgccggaca gagactgggc gtccacctgc ataccgaagc cagagccagg      480

catgcctggc agctgaccca gggcgccacc gtgctgggcc tgttcagagt gaccccagaa      540

attccagcag gactgccttc cccaaggtct gag                                   573


<210>  53
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  197 aa 41BBL segment

<400>  53

Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
1               5                   10                  15      


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
            20                  25                  30          


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
        35                  40                  45              


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
    50                  55                  60                  


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
65                  70                  75                  80  


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                85                  90                  95      


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
            100                 105                 110         


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
        115                 120                 125             


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
    130                 135                 140                 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
145                 150                 155                 160 


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                165                 170                 175     


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
            180                 185                 190         


Ser Pro Arg Ser Glu 
        195         


<210>  54
<211>  591
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 53

<400>  54
gctagagctt ctcctggctc tgccgcttct cccagactga gagaaggacc tgagctgagc       60

cctgatgatc ctgctggact gctggatctg cggcagggca tgtttgctca gttggtggcc      120

cagaacgtgc tgctgatcga tggccctctg tcctggtact ctgatccagg attggctggc      180

gtgtccctga ctggcggcct gtcttacaaa gaggacacca aagaactggt ggtggccaag      240

gccggcgtgt actacgtgtt ctttcagctg gaactgcgga gagtggtggc tggcgaagga      300

tctggatctg tgtctctggc cctgcatctg cagcctctga gaagtgctgc aggcgctgct      360

gcactggctc tgacagttga tctgcctcct gcctcctccg aggccagaaa ctccgccttt      420

ggcttccaag gcagactgct gcacctgtcc gctggacaga gactgggagt ccatctgcac      480

acagaggcca gagctagaca cgcttggcag ttgacacagg gcgctacagt gctgggcctg      540

tttagagtga cccctgagat tccagccggc ctgccatctc ctagatctga g               591


<210>  55
<211>  185
<212>  PRT
<213>  Artificial sequence

<220>
<223>  185 aa 41BBL segment

<400>  55

Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
1               5                   10                  15      


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
            20                  25                  30          


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
        35                  40                  45              


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
    50                  55                  60                  


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
65                  70                  75                  80  


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                85                  90                  95      


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
            100                 105                 110         


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
        115                 120                 125             


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
    130                 135                 140                 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
145                 150                 155                 160 


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                165                 170                 175     


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185 


<210>  56
<211>  555
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 55

<400>  56
ctgagagaag gacctgagct gagccctgat gatcctgctg gactgctgga tctgcggcag       60

ggcatgtttg ctcagttggt ggcccagaac gtgctgctga tcgatggccc tctgtcctgg      120

tactctgatc caggattggc tggcgtgtcc ctgactggcg gcctgtctta caaagaggac      180

accaaagaac tggtggtggc caaggccggc gtgtactacg tgttctttca gctggaactg      240

cggagagtgg tggctggcga aggatctgga tctgtgtctc tggccctgca tctgcagcct      300

ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag ttgatctgcc tcctgcctcc      360

tccgaggcca gaaactccgc ctttggcttc caaggcagac tgctgcacct gtccgctgga      420

cagagactgg gagtccatct gcacacagag gccagagcta gacacgcttg gcagttgaca      480

cagggcgcta cagtgctggg cctgtttaga gtgacccctg agattccagc cggcctgcca      540

tctcctagat ctgag                                                       555


<210>  57
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  199 aa 41BBL segment

<400>  57

Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
1               5                   10                  15      


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
            20                  25                  30          


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
        35                  40                  45              


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
    50                  55                  60                  


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
65                  70                  75                  80  


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                85                  90                  95      


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
            100                 105                 110         


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
        115                 120                 125             


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
    130                 135                 140                 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
145                 150                 155                 160 


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
                165                 170                 175     


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
            180                 185                 190         


Leu Pro Ser Pro Arg Ser Glu 
        195                 


<210>  58
<211>  597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 57

<400>  58
tctggcgcta gagcttctcc tggctctgcc gcttctccca gactgagaga aggacctgag       60

ctgagccctg atgatcctgc tggactgctg gatctgcggc agggcatgtt tgctcagttg      120

gtggcccaga acgtgctgct gatcgatggc cctctgtcct ggtactctga tccaggattg      180

gctggcgtgt ccctgactgg cggcctgtct tacaaagagg acaccaaaga actggtggtg      240

gccaaggccg gcgtgtacta cgtgttcttt cagctggaac tgcggagagt ggtggctggc      300

gaaggatctg gatctgtgtc tctggccctg catctgcagc ctctgagaag tgctgcaggc      360

gctgctgcac tggctctgac agttgatctg cctcctgcct cctccgaggc cagaaactcc      420

gcctttggct tccaaggcag actgctgcac ctgtccgctg gacagagact gggagtccat      480

ctgcacacag aggccagagc tagacacgct tggcagttga cacagggcgc tacagtgctg      540

ggcctgttta gagtgacccc tgagattcca gccggcctgc catctcctag atctgag         597


<210>  59
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -21-0  184 aa

<400>  59

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  60
<211>  552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 59

<400>  60
agagagggcc ctgagctgtc tcctgatgat cctgctggac tgctggacct gagacagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgattg atggccctct gtcctggtac      120

tctgatcctg gattggctgg cgtgtccctg actggcggcc tgtcttacaa agaggacacc      180

aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ctggcgaagg atctggatct gtgtctctgg ccctgcatct gcagcctctg      300

agaagtgctg caggcgctgc tgcactggct ctgacagttg atctgcctcc tgcctcctcc      360

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcatctgtc tgccggacag      420

agactgggag tgcacctcca tacagaggcc agagctagac acgcttggca gttgacacag      480

ggcgctacag tgctgggcct gtttagagtg acacctgaga tcccagccgg cctgccatct      540

ccaagatctg aa                                                          552


<210>  61
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -23-0 182 aa

<400>  61

Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
1               5                   10                  15      


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
            20                  25                  30          


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
        35                  40                  45              


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
    50                  55                  60                  


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
65                  70                  75                  80  


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                85                  90                  95      


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
            100                 105                 110         


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
        115                 120                 125             


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
    130                 135                 140                 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
145                 150                 155                 160 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                165                 170                 175     


Pro Ser Pro Arg Ser Glu 
            180         


<210>  62
<211>  546
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 61

<400>  62
ggccctgagc tgtctcctga tgatcctgct ggactgctgg acctgagaca gggcatgttt       60

gctcagctgg tggcccagaa cgtgctgctg attgatggcc ctctgtcctg gtactctgat      120

cctggattgg ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa      180

ctggtggtcg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      240

gtggctggcg aaggatctgg atctgtgtct ctggccctgc atctgcagcc tctgagaagt      300

gctgcaggcg ctgctgcact ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc      360

agaaactccg cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg acagagactg      420

ggagtgcacc tccatacaga ggccagagct agacacgctt ggcagttgac acagggcgct      480

acagtgctgg gcctgtttag agtgacacct gagatcccag ccggcctgcc atctccaaga      540

tctgaa                                                                 546


<210>  63
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -14-8 183 aa

<400>  63

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala 
            180             


<210>  64
<211>  551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 63

<400>  64
gatctgccgc ttctcctaga ctgagagagg gccctgagct gtctcctgat gatcctgctg       60

gactgctgga cctgagacag ggcatgtttg ctcagctggt ggcccagaac gtgctgctga      120

ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc ctgactggcg      180

gcctgtctta caaagaggac accaaagaac tggtggtcgc caaggccggc gtgtactacg      240

tgttctttca gctggaactg cggagagtgg tggctggcga aggatctgga tctgtgtctc      300

tggccctgca tctgcagcct ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag      360

ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc caaggcagac      420

tgctgcatct gtctgccgga cagagactgg gagtgcacct ccatacagag gccagagcta      480

gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgtttaga gtgacacctg      540

agatcccagc c                                                           551


<210>  65
<211>  176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -21-8  176 aa

<400>  65

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


<210>  66
<211>  528
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 65

<400>  66
agagagggcc ctgagctgtc tcctgatgat cctgctggac tgctggacct gagacagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgattg atggccctct gtcctggtac      120

tctgatcctg gattggctgg cgtgtccctg actggcggcc tgtcttacaa agaggacacc      180

aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ctggcgaagg atctggatct gtgtctctgg ccctgcatct gcagcctctg      300

agaagtgctg caggcgctgc tgcactggct ctgacagttg atctgcctcc tgcctcctcc      360

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcatctgtc tgccggacag      420

agactgggag tgcacctcca tacagaggcc agagctagac acgcttggca gttgacacag      480

ggcgctacag tgctgggcct gtttagagtg acacctgaga tcccagcc                   528


<210>  67
<211>  601
<212>  PRT
<213>  Artificial sequence

<220>
<223>  601 aa sc3x4-1BBL (-14-0) internal linker (GGGGS)x2+GGGG

<400>  67

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala 
        195                 200                 205             


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
    210                 215                 220                 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
225                 230                 235                 240 


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
                245                 250                 255     


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
            260                 265                 270         


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
        275                 280                 285             


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
    290                 295                 300                 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
305                 310                 315                 320 


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
                325                 330                 335     


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
            340                 345                 350         


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
        355                 360                 365             


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
    370                 375                 380                 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg 
                405                 410                 415     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            420                 425                 430         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        435                 440                 445             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    450                 455                 460                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
465                 470                 475                 480 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                485                 490                 495     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            500                 505                 510         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        515                 520                 525             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    530                 535                 540                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
545                 550                 555                 560 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                565                 570                 575     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            580                 585                 590         


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        595                 600     


<210>  68
<211>  1803
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 67

<400>  68
agcgccgcct cccctaggct gcgcgaggga ccagagctga gcccagacga tccagcagga       60

ctgctggacc tgaggcaggg aatgttcgca cagctggtgg cccagaacgt gctgctgatc      120

gacggccctc tgtcttggta cagcgatcca ggactggcag gcgtgagcct gacaggcgga      180

ctgtcctata aggaggatac caaggagctg gtggtggcaa aggcaggcgt gtactacgtg      240

ttcttccagc tggagctgag gagagtggtg gcaggagagg gatccggatc tgtgagcctg      300

gccctgcacc tgcagccact gcggagcgcc gcaggagcag ccgccctggc cctgaccgtg      360

gacctgccac ctgcatctag cgaggcacgg aattctgcct tcggctttca gggcagactg      420

ctgcacctga gcgccggaca gaggctggga gtgcacctgc acacagaggc aagggcaaga      480

cacgcatggc agctgacaca gggagcaacc gtgctgggac tgttccgcgt gacccctgag      540

atcccagcag gactgccatc cccccggtct gagggcggcg gcgggtccgg aggaggagga      600

tctggcggcg gcggcagcgc cgcctccccc aggctgcgcg agggacctga gctgtcccca      660

gacgatcctg ccggcctgct ggacctgaga cagggaatgt ttgcccagct ggtcgctcag      720

aacgtgctgc tgattgacgg ccccctgtcc tggtatagcg atcctggact ggcaggcgtg      780

tctctgacag gcggactgag ttacaaagaa gacactaaag aactggtcgt cgccaaagcc      840

ggcgtgtact acgtgttctt ccaactggag ctgaggaggg tcgtcgccgg cgaaggcagc      900

ggctctgtga gcctggccct gcacctgcaa ccactgagga gcgccgccgg cgccgccgcc      960

ctggccctga ctgtggacct gccaccagca tcctctgagg caaggaattc cgccttcggc     1020

ttccagggcc ggctgctgca cctgtctgcc ggacagagac tgggcgtcca cctgcatacc     1080

gaagccagag ccaggcatgc ctggcagctg acccagggcg ccaccgtgct gggcctgttc     1140

agagtgaccc cagaaattcc agcaggactg ccttccccaa ggtctgaggg aggaggagga     1200

agtggcggag gaggatccgg agggggaggg agcgccgcct ccccaagact gagagaggga     1260

ccagagctgt cccctgatga ccctgccggg ctgctggacc tgagacaagg catgttcgcc     1320

cagctggtcg cacaaaacgt gctgttaatt gacggcccac tgtcctggta ttccgaccct     1380

ggcctggccg gcgtgtccct gacaggcggc ctgtcttaca aagaagacac aaaagaactg     1440

gtcgtcgcta aagctggcgt gtactacgtg ttcttccaat tagaactgag aagggtcgtc     1500

gccggcgagg gcagcgggtc tgtgagcctg gccctgcacc tgcaaccgct gcggagcgcc     1560

gccggcgctg ccgccctggc cctgacagtg gacctgcctc cagcaagctc cgaggcaagg     1620

aatagcgcct tcggctttca aggccgcctg ctgcacctgt ccgccggaca gcggctgggc     1680

gtccacctgc acaccgaagc cagagcccgc catgcctggc agctgactca gggcgctacc     1740

gtgctgggcc tgttccgcgt gaccccagag atccctgccg gcctgccctc ccctcggtct     1800

gag                                                                   1803


<210>  69
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  aa sequence of full length SIRP

<400>  69

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  70
<211>  1512
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence of full length SIRP

<400>  70
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtat cagttgcagc tggagagtcg gccattctgc actgcactgt gacctccctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac cagcccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagagtccac aaagagagaa      300

aacatggact tttccatcag catcagtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccctgac acggagttta agtctggagc aggcactgag      420

ctgtctgtgc gtgccaaacc ctctgccccc gtggtatcgg gccctgcggc gagggccaca      480

cctcagcaca cagtgagctt cacctgcgag tcccacggct tctcacccag agacatcacc      540

ctgaaatggt tcaaaaatgg gaatgagctc tcagacttcc agaccaacgt ggaccccgta      600

ggagagagcg tgtcctacag catccacagc acagccaagg tggtgctgac ccgcgaggac      660

gttcactctc aagtcatctg cgaggtggcc cacgtcacct tgcaggggga ccctcttcgt      720

gggactgcca acttgtctga gaccatccga gttccaccca ccttggaggt tactcaacag      780

cccgtgaggg cagagaacca ggtgaatgtc acctgccagg tgaggaagtt ctacccccag      840

agactacagc tgacctggtt ggagaatgga aacgtgtccc ggacagaaac ggcctcaacc      900

gttacagaga acaaggatgg tacctacaac tggatgagct ggctcctggt gaatgtatct      960

gcccacaggg atgatgtgaa gctcacctgc caggtggagc atgacgggca gccagcggtc     1020

agcaaaagcc atgacctgaa ggtctcagcc cacccgaagg agcagggctc aaataccgcc     1080

gctgagaaca ctggatctaa tgaacggaac atctatattg tggtgggtgt ggtgtgcacc     1140

ttgctggtgg ccctactgat ggcggccctc tacctcgtcc gaatcagaca gaagaaagcc     1200

cagggctcca cttcttctac aaggttgcat gagcccgaga agaatgccag agaaataaca     1260

caggacacaa atgatatcac atatgcagac ctgaacctgc ccaaggggaa gaagcctgct     1320

ccccaggctg cggagcccaa caaccacacg gagtatgcca gcattcagac cagcccgcag     1380

cccgcgtcgg aggacaccct cacctatgct gacctggaca tggtccacct caaccggacc     1440

cccaagcagc cggcccccaa gcctgagccg tccttctcag agtacgccag cgtccaggtc     1500

ccgaggaagt ga                                                         1512


<210>  71
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL SIRPa DOMAIN (343AA)

<400>  71

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210>  72
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 71

<400>  72
gaggaggagc tgcaggtgat tcagcctgac aagtccgtat cagttgcagc tggagagtcg       60

gccattctgc actgcactgt gacctccctg atccctgtgg ggcccatcca gtggttcaga      120

ggagctggac cagcccggga attaatctac aatcaaaaag aaggccactt cccccgggta      180

acaactgttt cagagtccac aaagagagaa aacatggact tttccatcag catcagtaac      240

atcaccccag cagatgccgg cacctactac tgtgtgaagt tccggaaagg gagccctgac      300

acggagttta agtctggagc aggcactgag ctgtctgtgc gtgccaaacc ctctgccccc      360

gtggtatcgg gccctgcggc gagggccaca cctcagcaca cagtgagctt cacctgcgag      420

tcccacggct tctcacccag agacatcacc ctgaaatggt tcaaaaatgg gaatgagctc      480

tcagacttcc agaccaacgt ggaccccgta ggagagagcg tgtcctacag catccacagc      540

acagccaagg tggtgctgac ccgcgaggac gttcactctc aagtcatctg cgaggtggcc      600

cacgtcacct tgcaggggga ccctcttcgt gggactgcca acttgtctga gaccatccga      660

gttccaccca ccttggaggt tactcaacag cccgtgaggg cagagaacca ggtgaatgtc      720

acctgccagg tgaggaagtt ctacccccag agactacagc tgacctggtt ggagaatgga      780

aacgtgtccc ggacagaaac ggcctcaacc gttacagaga acaaggatgg tacctacaac      840

tggatgagct ggctcctggt gaatgtatct gcccacaggg atgatgtgaa gctcacctgc      900

caggtggagc atgacgggca gccagcggtc agcaaaagcc atgacctgaa ggtctcagcc      960

cacccgaagg agcagggctc aaataccgcc gctgagaaca ctggatctaa tgaacggaac     1020

atctatatt                                                             1029


<210>  73
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  116 aa SIRPa segment

<400>  73

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala 
        115     


<210>  74
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 73

<400>  74
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagct                   348


<210>  75
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  343 amino acids sequence of SIRPa with 4 point mutations

<400>  75

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210>  76
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 75

<400>  76
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagagt gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcatcaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctac                                                             1029


<210>  77
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  116 amino acids sequence of SIRPa with 4 point mutations

<400>  77

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala 
        115     


<210>  78
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 77

<400>  78
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagagt gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcatcaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagct                   348


<210>  79
<211>  989
<212>  PRT
<213>  Artificial sequence

<220>
<223>  989 aa hole chain of DSP305 and DSP105_V1

<400>  79

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys 
        275                 280                 285             


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
385                 390                 395                 400 


Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                405                 410                 415     


Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
            420                 425                 430         


Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
        435                 440                 445             


Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
    450                 455                 460                 


Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
465                 470                 475                 480 


Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
                485                 490                 495     


Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 
            500                 505                 510         


Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
        515                 520                 525             


Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 
    530                 535                 540                 


Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 
545                 550                 555                 560 


Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                565                 570                 575     


Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
        595                 600                 605             


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
    610                 615                 620                 


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
625                 630                 635                 640 


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                645                 650                 655     


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
            660                 665                 670         


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
        675                 680                 685             


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
    690                 695                 700                 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
705                 710                 715                 720 


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                725                 730                 735     


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
            740                 745                 750         


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
        755                 760                 765             


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    770                 775                 780                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
785                 790                 795                 800 


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                805                 810                 815     


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
            820                 825                 830         


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
        835                 840                 845             


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
    850                 855                 860                 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
865                 870                 875                 880 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                885                 890                 895     


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
            900                 905                 910         


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
        915                 920                 925             


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
    930                 935                 940                 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
945                 950                 955                 960 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                965                 970                 975     


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            980                 985                 


<210>  80
<211>  2967
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 79

<400>  80
gactctccag ataggccttg gaatccccct acctttagcc ccgccctgct ggtggtgaca       60

gagggcgata acgccacctt cacatgctct tttagcaaca cctccgagtc tttcgtgctg      120

aattggtaca ggatgagccc ttccaaccag acagacaagc tggcagcatt tcctgaggac      180

cgctcccagc caggccagga ttctcggttc agagtgaccc agctgccaaa tggcagggac      240

tttcacatga gcgtggtgcg cgcccggaga aacgattccg gcacatacct gtgcggagca      300

atctctctgg caccaaaggc acagatcaag gagtccctga gggcagagct gagggtgacc      360

gagaggaggg ccgaggtgcc aacagcacac ccatctccta gcccaaggcc agcaggacag      420

ggaggaggag gatccggagg aggaggatcc gagtctaagt atggaccacc atgccctcca      480

tgtccagcac ctgagtttga gggaggacct tccgtgttcc tgtttccccc taagccaaag      540

gacacactga tgatctccag gacaccagag gtgacctgcg tggtggtgga cgtgtctcag      600

gaggatcccg aggtgcagtt caactggtac gtggatggcg tggaggtgca caatgccaag      660

accaagccta gggaggagca gtttaactcc acataccgcg tggtgtctgt gctgaccgtg      720

ctgcaccagg attggctgaa cggcaaggag tataagtgta aggtgagcaa taagggcctg      780

ccaagctcca tcgagaagac catctccaag gcaaagggac agccaaggga gcctcaggtg      840

tatacactgc cacccagcca gtgcgagatg accaagaacc aggtgagcct gtcctgtgcc      900

gtgaagggct tctacccatc tgacatcgcc gtggagtggg agagcaatgg ccagcccgag      960

aacaattata agaccacacc tccagtgctg gactccgatg gctctttctt tctggtgtcc     1020

aggctgacag tggataagtc tcgctggcag gagggcaacg tgttttcttg tagcgtgatg     1080

cacgaggccc tgcacaatca ctacacccag aagtccctgt ctctgagcct gggcaagggc     1140

ggcggcggct ccggaggagg aggaagcgcc gcctccccta ggctgcgcga gggaccagag     1200

ctgagcccag acgatccagc aggactgctg gacctgaggc agggaatgtt cgcacagctg     1260

gtggcccaga acgtgctgct gatcgacggc cctctgtctt ggtacagcga tccaggactg     1320

gcaggcgtga gcctgacagg cggactgtcc tataaggagg ataccaagga gctggtggtg     1380

gcaaaggcag gcgtgtacta cgtgttcttc cagctggagc tgaggagagt ggtggcagga     1440

gagggatccg gatctgtgag cctggccctg cacctgcagc cactgcggag cgccgcagga     1500

gcagccgccc tggccctgac cgtggacctg ccacctgcat ctagcgaggc acggaattct     1560

gccttcggct ttcagggcag actgctgcac ctgagcgccg gacagaggct gggagtgcac     1620

ctgcacacag aggcaagggc aagacacgca tggcagctga cacagggagc aaccgtgctg     1680

ggactgttcc gcgtgacccc tgagatccca gcaggactgc catccccccg gtctgagggc     1740

ggcggcgggt ccggaggagg aggatctggc ggcggcggca gcgccgcctc ccccaggctg     1800

cgcgagggac ctgagctgtc cccagacgat cctgccggcc tgctggacct gagacaggga     1860

atgtttgccc agctggtcgc tcagaacgtg ctgctgattg acggccccct gtcctggtat     1920

agcgatcctg gactggcagg cgtgtctctg acaggcggac tgagttacaa agaagacact     1980

aaagaactgg tcgtcgccaa agccggcgtg tactacgtgt tcttccaact ggagctgagg     2040

agggtcgtcg ccggcgaagg cagcggctct gtgagcctgg ccctgcacct gcaaccactg     2100

aggagcgccg ccggcgccgc cgccctggcc ctgactgtgg acctgccacc agcatcctct     2160

gaggcaagga attccgcctt cggcttccag ggccggctgc tgcacctgtc tgccggacag     2220

agactgggcg tccacctgca taccgaagcc agagccaggc atgcctggca gctgacccag     2280

ggcgccaccg tgctgggcct gttcagagtg accccagaaa ttccagcagg actgccttcc     2340

ccaaggtctg agggaggagg aggaagtggc ggaggaggat ccggaggggg agggagcgcc     2400

gcctccccaa gactgagaga gggaccagag ctgtcccctg atgaccctgc cgggctgctg     2460

gacctgagac aaggcatgtt cgcccagctg gtcgcacaaa acgtgctgtt aattgacggc     2520

ccactgtcct ggtattccga ccctggcctg gccggcgtgt ccctgacagg cggcctgtct     2580

tacaaagaag acacaaaaga actggtcgtc gctaaagctg gcgtgtacta cgtgttcttc     2640

caattagaac tgagaagggt cgtcgccggc gagggcagcg ggtctgtgag cctggccctg     2700

cacctgcaac cgctgcggag cgccgccggc gctgccgccc tggccctgac agtggacctg     2760

cctccagcaa gctccgaggc aaggaatagc gccttcggct ttcaaggccg cctgctgcac     2820

ctgtccgccg gacagcggct gggcgtccac ctgcacaccg aagccagagc ccgccatgcc     2880

tggcagctga ctcagggcgc taccgtgctg ggcctgttcc gcgtgacccc agagatccct     2940

gccggcctgc cctcccctcg gtctgag                                         2967


<210>  81
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  379 aa knob chain of DSP305

<400>  81

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Gln Glu 
        275                 280                 285             


Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    370                 375                 


<210>  82
<211>  1137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 81

<400>  82
gactctccag ataggccttg gaatccccct acctttagcc ccgccctgct ggtggtgaca       60

gagggcgata acgccacctt cacatgctct tttagcaaca cctccgagtc tttcgtgctg      120

aattggtaca ggatgagccc ttccaaccag acagacaagc tggcagcatt tcctgaggac      180

cgctcccagc caggccagga ttctcggttc agagtgaccc agctgccaaa tggcagggac      240

tttcacatga gcgtggtgcg cgcccggaga aacgattccg gcacatacct gtgcggagca      300

atctctctgg caccaaaggc acagatcaag gagtccctga gggcagagct gagggtgacc      360

gagaggaggg ccgaggtgcc aacagcacac ccatctccta gcccaaggcc agcaggacag      420

ggcggaggag gcagcggagg aggaggatcc gagtctaagt acggaccacc atgccctcca      480

tgtcctgcac cagagttcga gggaggacca tccgtgttcc tgtttccacc taagcctaag      540

gacaccctga tgatctccag aacccccgag gtgacatgcg tggtggtgga cgtgtctcag      600

gaggatcctg aggtgcagtt caattggtac gtggatggcg tggaggtgca caacgccaag      660

acaaagcccc gggaggagca gtttaatagc acctacagag tggtgtccgt gctgacagtg      720

ctgcaccagg attggctgaa tggcaaggag tataagtgta aggtgagcaa caagggcctg      780

cctagctcca tcgagaagac catctccaag gccaagggcc agccaagaga gccacaggtg      840

tgcaccctgc caccaagcca ggaggagatg acaaagaatc aggtgtccct gtggtgtctg      900

gtgaagggct tctacccttc cgacatcgcc gtggagtggg agtctaacgg ccagccagag      960

aacaattaca agaccacacc tccagtgctg gactctgatg gcagcttctt tctgtattct     1020

cggctgaccg tggataagag cagatggcag gagggcaacg tgttcagctg ctccgtgatg     1080

cacgaggccc tgcacaacca ctatacacag aagtctctga gcctgtccct gggcaag        1137


<210>  83
<211>  389
<212>  PRT
<213>  Artificial sequence

<220>
<223>  389 aa knob chain of DSP305_V1

<400>  83

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
                165                 170                 175     


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            180                 185                 190         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        195                 200                 205             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    210                 215                 220                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
225                 230                 235                 240 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                245                 250                 255     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            260                 265                 270         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        275                 280                 285             


Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    290                 295                 300                 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
305                 310                 315                 320 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                325                 330                 335     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            340                 345                 350         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        355                 360                 365             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    370                 375                 380                 


Leu Ser Leu Gly Lys 
385                 


<210>  84
<211>  1167
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO 83

<400>  84
ccaggatggt tcctggacag ccccgatagg ccttggaatc cccctacctt ttcccctgcc       60

ctgctggtgg tgacagaggg cgacaacgcc accttcacat gctcttttag caacacctcc      120

gagtctttcg tgctgaattg gtacaggatg agcccttcca accagacaga taagctggca      180

gcatttccag aggaccgcag ccagcctgga caggattgcc ggttcagagt gacccagctg      240

ccaaatggca gggactttca catgtccgtg gtgcgcgccc ggagaaacga ttctggcaca      300

tacctgtgcg gagcaatcag cctggcacca aaggcacaga tcaaggagtc cctgagggca      360

gagctgaggg tgaccgagag gagggccgag gtgccaacag cacacccatc tcctagccca      420

cggcccgccg gccagttcca gaccctggtg ggaggaggag gaagcggagg aggaggatcc      480

gagtctaagt acggaccacc atgccctcca tgtcctgcac cagagtttga gggcggccca      540

tccgtgttcc tgtttccccc taagcccaag gacaccctga tgatcagccg gaccccagag      600

gtgacatgcg tggtggtgga cgtgagccag gaggatcctg aggtgcagtt caattggtac      660

gtggatggcg tggaggtgca caacgccaag acaaagcccc gggaggagca gtttaattcc      720

acctacagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa tggcaaggag      780

tataagtgta aggtgtccaa caagggcctg cccagctcca tcgagaagac catctctaag      840

gccaagggcc agccaagaga gccacaggtg tgcaccctgc caccatccca ggaggagatg      900

acaaagaatc aggtgtctct gtggtgtctg gtgaagggct tctacccttc tgacatcgca      960

gtggagtggg agagcaacgg acagccagag aacaattaca agaccacacc tccagtgctg     1020

gactctgatg gcagcttctt tctgtatagc cggctgaccg tggataagtc cagatggcag     1080

gagggcaacg tgttcagctg ttccgtgatg cacgaggccc tgcacaacca ctatacacag     1140

aagtctctga gcctgtccct gggcaag                                         1167


<210>  85
<211>  1192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1192 aa TSP111 and TSP111_V2 "hole"  chain

<400>  85

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    450                 455                 460                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
        595                 600                 605             


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
    610                 615                 620                 


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
625                 630                 635                 640 


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
                645                 650                 655     


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
            660                 665                 670         


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
        675                 680                 685             


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
    690                 695                 700                 


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
705                 710                 715                 720 


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                725                 730                 735     


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
            740                 745                 750         


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
        755                 760                 765             


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly 
    770                 775                 780                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser 
785                 790                 795                 800 


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
                805                 810                 815     


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
            820                 825                 830         


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
        835                 840                 845             


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
    850                 855                 860                 


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
865                 870                 875                 880 


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                885                 890                 895     


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
            900                 905                 910         


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
        915                 920                 925             


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
    930                 935                 940                 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
945                 950                 955                 960 


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
                965                 970                 975     


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser 
            980                 985                 990         


Gly Gly Gly Gly Ser Gly Gly Gly  Gly Ser Ala Ala Ser  Pro Arg Leu 
        995                 1000                 1005             


Arg Glu  Gly Pro Glu Leu Ser  Pro Asp Asp Pro Ala  Gly Leu Leu 
    1010                 1015                 1020             


Asp Leu  Arg Gln Gly Met Phe  Ala Gln Leu Val Ala  Gln Asn Val 
    1025                 1030                 1035             


Leu Leu  Ile Asp Gly Pro Leu  Ser Trp Tyr Ser Asp  Pro Gly Leu 
    1040                 1045                 1050             


Ala Gly  Val Ser Leu Thr Gly  Gly Leu Ser Tyr Lys  Glu Asp Thr 
    1055                 1060                 1065             


Lys Glu  Leu Val Val Ala Lys  Ala Gly Val Tyr Tyr  Val Phe Phe 
    1070                 1075                 1080             


Gln Leu  Glu Leu Arg Arg Val  Val Ala Gly Glu Gly  Ser Gly Ser 
    1085                 1090                 1095             


Val Ser  Leu Ala Leu His Leu  Gln Pro Leu Arg Ser  Ala Ala Gly 
    1100                 1105                 1110             


Ala Ala  Ala Leu Ala Leu Thr  Val Asp Leu Pro Pro  Ala Ser Ser 
    1115                 1120                 1125             


Glu Ala  Arg Asn Ser Ala Phe  Gly Phe Gln Gly Arg  Leu Leu His 
    1130                 1135                 1140             


Leu Ser  Ala Gly Gln Arg Leu  Gly Val His Leu His  Thr Glu Ala 
    1145                 1150                 1155             


Arg Ala  Arg His Ala Trp Gln  Leu Thr Gln Gly Ala  Thr Val Leu 
    1160                 1165                 1170             


Gly Leu  Phe Arg Val Thr Pro  Glu Ile Pro Ala Gly  Leu Pro Ser 
    1175                 1180                 1185             


Pro Arg  Ser Glu 
    1190         


<210>  86
<211>  3577
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 85

<400>  86
gaggaggagc tgcaggtcat ccagcccgat aagtctgtgc tggtggcagc aggagagacc       60

gccacactga gatgcaccgc cacaagcctg atcccagtgg gaccaatcca gtggtttagg      120

ggagcaggac ctggaaggga gctgatctac aaccagaagg agggccactt cccaagggtg      180

accacagtgt ccgacctgac caagcggaac aatatggatt tttctatcag aatcggcaat      240

atcacacctg ccgacgccgg cacctactat tgcgtgaagt tcagaaaggg cagcccagac      300

gatgtggagt ttaagagcgg agcaggaacc gagctgtccg tgagagccaa gccttctgcc      360

ccagtggtga gcggaccagc agcaagggca accccacagc acacagtgtc cttcacctgt      420

gagagccacg gcttttcccc acgcgatatc acactgaagt ggttcaagaa cggcaatgag      480

ctgagcgact ttcagaccaa cgtggatccc gtgggcgagt ctgtgagcta ctccatccac      540

tctacagcca aggtggtgct gacccgggag gacgtgcaca gccaggtcat ctgcgaggtg      600

gcacacgtga ccctgcaggg cgatcctctg agaggcacag ccaatctgag cgagaccatc      660

agggtgcccc ctacactgga ggtgacccag cagcccgtga gggcagagaa ccaagtgaat      720

gtgacatgtc aggtgcggaa gttctaccct cagagactgc agctgacctg gctggagaac      780

ggcaacgtga gccggaccga gacagccagc accgtgacag agaacaagga cggcacatat      840

aattggatgt cttggctgct ggtgaacgtg agcgcccaca gggacgatgt gaagctgacc      900

tgccaggtgg agcacgacgg acagccagcc gtgtctaaga gccacgatct gaaggtgagc      960

gcccacccta aggagcaggg ctccaacaca gccgccgaga ataccggcag caacgagaga     1020

aatatctacg gaggaggagg atccggagga ggaggatccg agtctaagta tggaccacca     1080

tgccctccat gtccagcacc tgagtttgag ggaggacctt ccgtgttcct gtttccccct     1140

aagccaaagg acacactgat gatctccagg acaccagagg tgacctgcgt ggtggtggac     1200

gtgtctcagg aggatcccga ggtgcagttc aactggtacg tggatggcgt ggaggtgcac     1260

aatgccaaga ccaagcctag ggaggagcag tttaactcca cataccgcgt ggtgtctgtg     1320

ctgaccgtgc tgcaccagga ttggctgaac ggcaaggagt ataagtgtaa ggtgagcaat     1380

aagggcctgc caagctccat cgagaagacc atctccaagg caaagggaca gccaagggag     1440

cctcaggtgt atacactgcc acccagccag tgcgagatga ccaagaacca ggtgagcctg     1500

tcctgtgccg tgaagggctt ctacccatct gacatcgccg tggagtggga gagcaatggc     1560

cagcccgaga acaattataa gaccacacct ccagtgctgg actccgatgg ctctttcttt     1620

ctggtgtcca ggctgacagt ggataagtct cgctggcagg agggcaacgt gttttcttgt     1680

agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgtc tctgagcctg     1740

ggcaagggcg gcggcggctc cggaggagga ggaagcgccg cctcccctag gctgcgcgag     1800

ggaccagagc tgagcccaga cgatccagca ggactgctgg acctgaggca gggaatgttc     1860

gcacagctgg tggcccagaa cgtgctgctg atcgacggcc ctctgtcttg gtacagcgat     1920

ccaggactgg caggcgtgag cctgacaggc ggactgtcct ataaggagga taccaaggag     1980

ctggtggtgg caaaggcagg cgtgtactac gtgttcttcc agctggagct gaggagagtg     2040

gtggcaggag agggatccgg atctgtgagc ctggccctgc acctgcagcc actgcggagc     2100

gccgcaggag cagccgccct ggccctgacc gtggacctgc cacctgcatc tagcgaggca     2160

cggaattctg ccttcggctt tcagggcaga ctgctgcacc tgagcgccgg acagaggctg     2220

ggagtgcacc tgcacacaga ggcaagggca agacacgcat ggcagctgac acagggagca     2280

accgtgctgg gactgttccg cgtgacccct gagatcccag caggactgcc atccccccgg     2340

tctgagggcg gcggcgggtc cggaggagga ggatctggcg gcggcggcag cgccgcctcc     2400

cccaggctgc gcgagggacc tgagctgtcc ccagacgatc ctgccggcct gctggacctg     2460

agacagggaa tgtttgccca gctggtcgct cagaacgtgc tgctgattga cggccccctg     2520

tcctggtata gcgatcctgg actggcaggc gtgtctctga caggcggact gagttacaaa     2580

gaagacacta aagaactggt cgtcgccaaa gccggcgtgt actacgtgtt cttccaactg     2640

gagctgagga gggtcgtcgc cggcgaaggc agcggctctg tgagcctggc cctgcacctg     2700

caaccactga ggagcgccgc cggcgccgcc gccctggccc tgactgtgga cctgccacca     2760

gcatcctctg aggcaaggaa ttccgccttc ggcttccagg gccggctgct gcacctgtct     2820

gccggacaga gactgggcgt ccacctgcat accgaagcca gagccaggca tgcctggcag     2880

ctgacccagg gcgccaccgt gctgggcctg ttcagagtga ccccagaaat tccagcagga     2940

ctgccttccc caaggtctga gggaggagga ggaagtggcg gaggaggatc cggaggggga     3000

gggagcgccg cctccccaag actgagagag ggaccagagc tgtcccctga tgaccctgcc     3060

gggctgctgg acctgagaca aggcatgttc gcccagctgg tcgcacaaaa cgtgctgtta     3120

attgacggcc cactgtcctg gtattccgac cctggcctgg ccggcgtgtc cctgacaggc     3180

ggcctgtctt acaaagaaga cacaaaagaa ctggtcgtcg ctaaagctgg cgtgtactac     3240

gtgttcttcc aattagaact gagaagggtc gtcgccggcg agggcagcgg gtctgtgagc     3300

ctggccctgc acctgcaacc gctgcggagc gccgccggcg ctgccgccct ggccctgaca     3360

gtggacctgc ctccagcaag ctccgaggca aggaatagcg ccttcggctt tcaaggccgc     3420

ctgctgcacc tgtccgccgg acagcggctg ggcgtccacc tgcacaccga agccagagcc     3480

cgccatgcct ggcagctgac tcagggcgct accgtgctgg gcctgttccg cgtgacccca     3540

gagatccctg ccggcctgcc ctcccctcgg tctgagt                              3577


<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  379 aa TSP111_V1 "hole"  chain

<400>  89

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys 
        275                 280                 285             


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    370                 375                 


<210>  90
<211>  1137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 89

<400>  90
gactctccag ataggccttg gaatccccct acctttagcc ccgccctgct ggtggtgaca       60

gagggcgata acgccacctt cacatgctct tttagcaaca cctccgagtc tttcgtgctg      120

aattggtaca ggatgagccc ttccaaccag acagacaagc tggcagcatt tcctgaggac      180

cgcagccagc caggacagga ttcccggttc agagtgaccc agctgccaaa tggcagggac      240

tttcacatgt ctgtggtgcg cgcccggaga aacgatagcg gcacatacct gtgcggagca      300

atctccctgg caccaaaggc acagatcaag gagtccctga gggcagagct gagggtgacc      360

gagaggaggg ccgaggtgcc aacagcacac ccatctccta gcccaaggcc agcaggacag      420

ggaggaggag gctctggagg aggaggatcc gagtctaagt acggaccacc atgccctcca      480

tgtcctgcac cagagttcga gggaggacca tccgtgttcc tgtttccacc taagcctaag      540

gacaccctga tgatctccag aacccccgag gtgacatgcg tggtggtgga cgtgtctcag      600

gaggatcctg aggtgcagtt caattggtac gtggatggcg tggaggtgca caacgccaag      660

acaaagcccc gggaggagca gtttaattct acctacagag tggtgagcgt gctgacagtg      720

ctgcaccagg attggctgaa tggcaaggag tataagtgta aggtgagcaa caagggcctg      780

cctagctcca tcgagaagac catctccaag gccaagggcc agccaagaga gccccaggtg      840

tacaccctgc cacccagcca gtgcgagatg acaaagaatc aggtgagcct gtcctgtgcc      900

gtgaagggct tctaccctag cgacatcgca gtggagtggg agtccaacgg acagccagag      960

aacaattata agaccacacc tccagtgctg gactccgatg gctctttctt tctggtgtcc     1020

cggctgaccg tggataagag ccggtggcag gagggcaacg tgttcagctg cagcgtgatg     1080

cacgaggccc tgcacaacca ctatacacag aagtccctgt ctctgagcct gggcaag        1137


<210>  91
<211>  1192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1192 aa TSP111_V1 "knob"  chain

<400>  91

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    450                 455                 460                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
        595                 600                 605             


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
    610                 615                 620                 


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
625                 630                 635                 640 


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
                645                 650                 655     


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
            660                 665                 670         


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
        675                 680                 685             


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
    690                 695                 700                 


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
705                 710                 715                 720 


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                725                 730                 735     


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
            740                 745                 750         


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
        755                 760                 765             


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly 
    770                 775                 780                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser 
785                 790                 795                 800 


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
                805                 810                 815     


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
            820                 825                 830         


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
        835                 840                 845             


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
    850                 855                 860                 


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
865                 870                 875                 880 


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                885                 890                 895     


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
            900                 905                 910         


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
        915                 920                 925             


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
    930                 935                 940                 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
945                 950                 955                 960 


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
                965                 970                 975     


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser 
            980                 985                 990         


Gly Gly Gly Gly Ser Gly Gly Gly  Gly Ser Ala Ala Ser  Pro Arg Leu 
        995                 1000                 1005             


Arg Glu  Gly Pro Glu Leu Ser  Pro Asp Asp Pro Ala  Gly Leu Leu 
    1010                 1015                 1020             


Asp Leu  Arg Gln Gly Met Phe  Ala Gln Leu Val Ala  Gln Asn Val 
    1025                 1030                 1035             


Leu Leu  Ile Asp Gly Pro Leu  Ser Trp Tyr Ser Asp  Pro Gly Leu 
    1040                 1045                 1050             


Ala Gly  Val Ser Leu Thr Gly  Gly Leu Ser Tyr Lys  Glu Asp Thr 
    1055                 1060                 1065             


Lys Glu  Leu Val Val Ala Lys  Ala Gly Val Tyr Tyr  Val Phe Phe 
    1070                 1075                 1080             


Gln Leu  Glu Leu Arg Arg Val  Val Ala Gly Glu Gly  Ser Gly Ser 
    1085                 1090                 1095             


Val Ser  Leu Ala Leu His Leu  Gln Pro Leu Arg Ser  Ala Ala Gly 
    1100                 1105                 1110             


Ala Ala  Ala Leu Ala Leu Thr  Val Asp Leu Pro Pro  Ala Ser Ser 
    1115                 1120                 1125             


Glu Ala  Arg Asn Ser Ala Phe  Gly Phe Gln Gly Arg  Leu Leu His 
    1130                 1135                 1140             


Leu Ser  Ala Gly Gln Arg Leu  Gly Val His Leu His  Thr Glu Ala 
    1145                 1150                 1155             


Arg Ala  Arg His Ala Trp Gln  Leu Thr Gln Gly Ala  Thr Val Leu 
    1160                 1165                 1170             


Gly Leu  Phe Arg Val Thr Pro  Glu Ile Pro Ala Gly  Leu Pro Ser 
    1175                 1180                 1185             


Pro Arg  Ser Glu 
    1190         


<210>  92
<211>  3576
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na of SEQ ID NO 91

<400>  92
gaggaggagc tgcaggtcat ccagcccgat aagtctgtgc tggtggcagc aggagagacc       60

gccacactga gatgcaccgc cacaagcctg atcccagtgg gaccaatcca gtggtttagg      120

ggagcaggac ctggaaggga gctgatctac aaccagaagg agggccactt cccaagggtg      180

accacagtgt ccgacctgac caagcggaac aatatggatt tttctatcag aatcggcaat      240

atcacacctg ccgacgccgg cacctactat tgcgtgaagt tcagaaaggg cagcccagac      300

gatgtggagt ttaagtccgg agcaggaacc gagctgtctg tgagagcaaa gcctagcgcc      360

ccagtggtgt ccggaccagc agcaagggca accccacagc acacagtgtc cttcacctgt      420

gagtcccacg gcttttctcc acgcgatatc acactgaagt ggttcaagaa cggcaatgag      480

ctgagcgact ttcagaccaa cgtggatccc gtgggcgagt ctgtgagcta ctccatccac      540

tctacagcca aggtggtgct gacccgggag gacgtgcaca gccaggtcat ctgcgaggtg      600

gcacacgtga ccctgcaggg cgatcctctg agaggcacag ccaatctgtc cgagaccatc      660

agggtgcccc ctacactgga ggtgacccag cagcccgtga gggcagagaa ccaagtgaat      720

gtgacatgtc aggtgcggaa gttctaccct cagagactgc agctgacctg gctggagaac      780

ggcaatgtga gccgcaccga gacagcctcc accgtgacag agaacaagga cggcacatat      840

aattggatga gctggctgct ggtgaacgtg tccgcccaca gggacgatgt gaagctgacc      900

tgccaggtgg agcacgacgg acagccagcc gtgtctaaga gccacgatct gaaggtgtcc      960

gcccacccta aggagcaggg ctctaacaca gccgccgaga ataccggcag caacgagaga     1020

aatatctacg gaggaggagg atccggagga ggaggatccg agtctaagta tggaccacca     1080

tgccctccat gtccagcacc tgagtttgag ggaggaccta gcgtgttcct gtttccccct     1140

aagccaaagg acacactgat gatctccagg acaccagagg tgacctgcgt ggtggtggac     1200

gtgtctcagg aggatcccga ggtgcagttc aactggtacg tggatggcgt ggaggtgcac     1260

aatgccaaga ccaagcctag ggaggagcag tttaactcta cataccgcgt ggtgagcgtg     1320

ctgaccgtgc tgcaccagga ttggctgaac ggcaaggagt ataagtgtaa ggtgagcaat     1380

aagggcctgc caagctccat cgagaagacc atctccaagg caaagggaca gccaagggag     1440

cctcaggtgt gcacactgcc accctctcag gaggagatga ccaagaacca ggtgagcctg     1500

tggtgtctgg tgaagggctt ctacccaagc gacatcgccg tggagtggga gtccaatggc     1560

cagcccgaga acaattacaa gaccacacct ccagtgctgg actctgatgg cagcttcttt     1620

ctgtattcta ggctgacagt ggataagagc cgctggcagg agggcaacgt gtttagctgt     1680

tccgtgatgc acgaggccct gcacaatcac tatacccaga agtctctgag cctgtccctg     1740

ggcaagggcg gcggcggcag cggcggagga ggatccgccg cctctcctag gctgagggag     1800

ggaccagagc tgagcccaga cgatccagca ggactgctgg acctgaggca gggaatgttc     1860

gcacagctgg tggcccagaa cgtgctgctg atcgacggcc ctctgagctg gtactccgat     1920

ccaggactgg caggcgtgtc cctgacaggc ggactgtctt ataaggagga taccaaggag     1980

ctggtggtgg caaaggcagg cgtgtactac gtgttcttcc agctggagct gaggagagtg     2040

gtggcaggag agggctctgg aagcgtgtcc ctggccctgc acctgcagcc actgcggagc     2100

gccgcaggag cagccgccct ggccctgacc gtggacctgc cacctgcatc tagcgaggca     2160

cggaattctg ccttcggctt tcagggcaga ctgctgcacc tgagcgccgg acagaggctg     2220

ggagtgcacc tgcacacaga ggcaagggca agacacgcat ggcagctgac acagggagca     2280

accgtgctgg gactgttccg cgtgacccct gagatcccag caggactgcc atctccacgg     2340

agcgagggcg gcggcggctc tggaggagga ggaagcggag gcggcggctc cgccgcttct     2400

cccaggctgc gcgagggacc tgagctgtcc ccagacgatc ctgccggcct gctggacctg     2460

agacagggaa tgtttgccca gctggtcgct cagaacgtgc tgctgattga cggccccctg     2520

tcctggtatt ccgatcctgg actggcaggc gtgagcctga caggcggcct gagctacaaa     2580

gaagacacta aagaactggt cgtcgccaaa gccggcgtgt actacgtgtt cttccaactg     2640

gagctgagga gggtcgtcgc cggcgaagga tccggcagcg tgtccctggc cctgcacctg     2700

caaccactga ggagcgccgc cggcgccgcc gccctggccc tgactgtgga cctgccacca     2760

gcatcctctg aggcaaggaa ttccgccttc ggcttccagg gccggctgct gcacctgtct     2820

gccggacaga gactgggcgt ccacctgcat accgaagcca gagccaggca tgcctggcag     2880

ctgacccagg gcgccaccgt gctgggcctg ttcagagtga ccccagaaat tccagcagga     2940

ctgccttctc caaggagcga gggcggcggg ggctccggcg gaggaggctc tggcggcggc     3000

ggctccgccg cctctccaag gctgcgcgag ggaccagagc tgtcccctga tgaccctgcc     3060

gggctgctgg acctgagaca aggcatgttc gcccagctgg tcgcacaaaa cgtgctgtta     3120

attgacggcc cactgtcctg gtatagcgac cctggcctgg ccggcgtgtc tctgacaggc     3180

ggactgagct acaaagaaga tactaaagaa ctggtcgtgg ccaaagctgg cgtgtactac     3240

gtgttcttcc aattagaact gagaagggtc gtcgccggcg agggatccgg gagcgtgtcc     3300

ctggccctgc acctgcaacc gctgcggagc gccgccggcg ctgccgccct ggccctgaca     3360

gtggacctgc ctccagcaag ctccgaggca aggaatagcg ccttcggctt tcaaggccgc     3420

ctgctgcacc tgtccgccgg acagcggctg ggcgtccacc tgcacaccga agccagagcc     3480

cgccatgcct ggcagctgac tcagggcgct accgtgctgg gcctgttccg cgtgacccca     3540

gagatccctg caggactgcc ctctcctcgg agcgag                               3576


<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial signal peptide

<400>  95

Met Glu Ser Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Gly Val His Ala 
            20      


<210>  96
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  96

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  97
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  97

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  98
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may repeat 1-4 times

<400>  98

Gly Gly Gly Gly Ser 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  99

Gly Gly Gly Gly Ser 
1               5   


<210>  100
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  100

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  101
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may repeat 1-3 times

<400>  101

Glu Ala Ala Ala Lys 
1               5   


<210>  102
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence


<220>
<221>  REPEAT
<222>  (2)..(6)
<223>  repeat 2-5 times

<400>  102

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  103
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  103

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  104
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  104

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  105
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  105

Pro Ala Pro Ala Pro 
1               5   


<210>  106
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  106

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  107
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  107

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  108
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  108

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  109
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  109

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  110
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  110

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  111
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  111

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  112
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  112

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  113
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  113

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  114
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker peptide sequence

<400>  114

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  115
<211>  398
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-4, AA 22-419 (Q8N423-1 UniParc) AA SEQUENCE

<400>  115

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser 
385                 390                 395             


<210>  116
<211>  1194
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-4, AA 22-419 (Q8N423-1 UniParc) NA SEQUENCE

<400>  116
cagaccggca caatccccaa gcctaccctg tgggccgagc cagatagcgt gatcacccag       60

ggctcccccg tgacactgtc ttgccagggc agcctggagg cacaggagta ccggctgtat      120

agagagaaga agagcgcctc ctggatcacc cggatcagac ccgagctggt gaagaacggc      180

cagtttcaca tcccttccat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

tctcgggcca gatggagcga gctgtccgac cccctggtgc tggtcatgac cggcgcctat      300

ccaaagccca cactgtccgc ccagccttct ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcaccccc agtgtctgaa tagccagcct cacgcccggg gcagctccag agccatcttc      480

tctgtgggcc ctgtgagccc aaaccggaga tggtcccaca ggtgctacgg ctatgacctg      540

aacagcccat acgtgtggtc tagcccctct gatctgctgg agctgctggt gcctggcgtg      600

agcaagaagc catctctgag cgtgcagcca ggccctgtgg tggcacctgg cgagtctctg      660

accctgcagt gcgtgagcga cgtgggctac gatcggttcg tgctgtataa ggagggagag      720

agggatctga ggcagctgcc aggcagacag cctcaggcag gactgtccca ggcaaacttt      780

acactgggcc ccgtgagccg gagctacggc ggacagtacc gctgctatgg agcacacaat      840

ctgtcctctg agtgttctgc ccccagcgac cccctggaca tcctgatcac cggccagatc      900

aggggcacac cattcatcag cgtgcagcca ggaccaaccg tggcctccgg cgagaacgtg      960

acactgctgt gccagagctg gcgccagttc cacacctttc tgctgacaaa ggcaggagca     1020

gcagacgcac ctctgaggct gcgctccatc cacgagtacc caaagtatca ggccgagttt     1080

ccaatgagcc ccgtgacctc cgcccacgca ggcacataca gatgctatgg cagcctgaac     1140

agcgacccct acctgctgag ccacccttcc gagccactgg agctggtggt gtcc           1194


<210>  117
<211>  198
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-2, AA 22-219 (Q8N423-1 UniParc) AA SEQUENCE

<400>  117

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro 
        195             


<210>  118
<211>  594
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-2, AA 22-219 (Q8N423-1 UniParc) NA SEQUENCE

<400>  118
cagaccggca caatccccaa gcctaccctg tgggccgagc cagatagcgt gatcacccag       60

ggctcccccg tgacactgtc ttgccagggc agcctggagg cacaggagta ccggctgtat      120

agagagaaga agagcgcctc ctggatcacc cggatcagac ccgagctggt gaagaacggc      180

cagtttcaca tcccttccat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

tctcgggcca gatggagcga gctgtccgac cccctggtgc tggtcatgac cggcgcctat      300

ccaaagccca cactgtccgc ccagccttct ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcaccccc agtgtctgaa tagccagcct cacgcccggg gcagctccag agccatcttc      480

tctgtgggcc ctgtgagccc aaaccggaga tggtcccaca ggtgctacgg ctatgacctg      540

aacagcccat acgtgtggtc tagcccctct gatctgctgg agctgctggt gcct            594


<210>  119
<211>  148
<212>  PRT
<213>  Artificial sequence

<220>
<223>   CD40L, AA 114-261 C194S (P29965 Uniprot) AA SEQUENCE

<400>  119

Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
1               5                   10                  15      


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
            20                  25                  30          


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
        35                  40                  45              


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
    50                  55                  60                  


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
65                  70                  75                  80  


Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
                85                  90                  95      


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
            100                 105                 110         


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
        115                 120                 125             


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
    130                 135                 140                 


Leu Leu Lys Leu 
145             


<210>  120
<211>  444
<212>  DNA
<213>  Artificial sequence

<220>
<223>   CD40L, AA 114-261 C194S (P29965 Uniprot) NA SEQUENCE

<400>  120
cagaagggcg atcagaatcc tcagattgcc gcccacgtga tctctgaggc ctctagcaag       60

accacaagcg tgctgcagtg ggcagaaaaa gggtactata caatgtctaa caatctggtg      120

accctggaga acggcaagca actgaccgtc aaaagacagg gcctgtacta catctacgct      180

caggtgacct tctgcagcaa tagggaggcc tcctctcagg caccttttat cgcctctctg      240

agcctgaagt ccccaggccg gttcgagaga atcctgttaa gggcagcaaa cactcacagc      300

tccgccaaac catgtggaca gcagagcata cacctgggcg gcgtgttcga gctgcaaccg      360

ggagcctccg tgtttgtcaa tgtgaccgac ccatcccagg tgtctcacgg caccggcttc      420

accagcttcg gcctgctgaa gctg                                             444


<210>  121
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>   sc3xCD40L, AA 114-261 C194S (P29965 Uniprot) internal linker 
       3x(GGGGS) AA SEQUENCE

<400>  121

Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
1               5                   10                  15      


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
            20                  25                  30          


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
        35                  40                  45              


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
    50                  55                  60                  


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
65                  70                  75                  80  


Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
                85                  90                  95      


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
            100                 105                 110         


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
        115                 120                 125             


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
    130                 135                 140                 


Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
                165                 170                 175     


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
            180                 185                 190         


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
        195                 200                 205             


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
    210                 215                 220                 


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
225                 230                 235                 240 


Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
                245                 250                 255     


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
            260                 265                 270         


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
        275                 280                 285             


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
    290                 295                 300                 


Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
                325                 330                 335     


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
            340                 345                 350         


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
        355                 360                 365             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
    370                 375                 380                 


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
385                 390                 395                 400 


Pro Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg 
                405                 410                 415     


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
            420                 425                 430         


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
        435                 440                 445             


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
    450                 455                 460                 


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
465                 470                 


<210>  122
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>   CD40L full ECD, AA 47-261 (P29965 Uniprot) AA SEQUENCE

<400>  122

His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210>  123
<211>  148
<212>  PRT
<213>  Artificial sequence

<220>
<223>   CD40L, AA 114-261 NO MUTATION (P29965 Uniprot) AA SEQUENCE

<400>  123

Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
1               5                   10                  15      


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
            20                  25                  30          


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
        35                  40                  45              


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
    50                  55                  60                  


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
65                  70                  75                  80  


Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
                85                  90                  95      


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
            100                 105                 110         


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
        115                 120                 125             


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
    130                 135                 140                 


Leu Leu Lys Leu 
145             


<210>  124
<211>  444
<212>  DNA
<213>  Artificial sequence

<220>
<223>   CD40L, AA 114-261 NO MUTATION (P29965 Uniprot) NA SEQUENCE

<400>  124
cagaagggcg atcagaatcc tcagattgcc gcccacgtga tctctgaggc ctctagcaag       60

accacaagcg tgctgcagtg ggcagaaaaa gggtactata caatgtctaa caatctggtg      120

accctggaga acggcaagca actgaccgtc aaaagacagg gcctgtacta catctacgct      180

caggtgacct tctgcagcaa tagggaggcc tcctctcagg caccttttat cgcctctctg      240

tgcctgaagt ccccaggccg gttcgagaga atcctgttaa gggcagcaaa cactcacagc      300

tccgccaaac catgtggaca gcagagcata cacctgggcg gcgtgttcga gctgcaaccg      360

ggagcctccg tgtttgtcaa tgtgaccgac ccatcccagg tgtctcacgg caccggcttc      420

accagcttcg gcctgctgaa gctg                                             444


<210>  125
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>   Siglec 10, AA 18-145 NO MUTATION (Q96LC7-1 Uniprot) AA SEQUENCE

<400>  125

Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro Glu 
1               5                   10                  15      


Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln Asp 
            20                  25                  30          


Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val Thr 
        35                  40                  45              


Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg Glu 
    50                  55                  60                  


Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro Ala 
65                  70                  75                  80  


Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp Glu 
                85                  90                  95      


Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr Asn 
            100                 105                 110         


Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln Lys 
        115                 120                 125             


<210>  126
<211>  186
<212>  DNA
<213>  Artificial sequence

<220>
<223>   Siglec 10, AA 18-145 NO MUTATION (Q96LC7-1 Uniprot) AA SEQUENCE

<400>  126
gatggccggt tttggatcag agtgcaggag tccgtgatgg tgcctgaggg cctgtgcatc       60

agcgtgccat gctccttctc ttaccccaga caggactgga ccggctctac acccgcctac      120

ggctattggt ttaaggccgt gaccgagaca acaaagggcg cccctgtggc cacaaaccac      180

cagagc                                                                 186


<210>  127
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>   Siglec 10, AA 18-145 plus C36S (Q96LC7-1 Uniprot) AA SEQUENCE

<400>  127

Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro Glu 
1               5                   10                  15      


Gly Leu Ser Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln Asp 
            20                  25                  30          


Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val Thr 
        35                  40                  45              


Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg Glu 
    50                  55                  60                  


Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro Ala 
65                  70                  75                  80  


Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp Glu 
                85                  90                  95      


Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr Asn 
            100                 105                 110         


Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln Lys 
        115                 120                 125             


<210>  128
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>   Siglec 10, AA 18-145 plus C36S (Q96LC7-1 Uniprot) NA SEQUENCE

<400>  128
gatggccggt tttggatcag agtgcaggag tccgtgatgg tgcctgaggg cctgtctatc       60

agcgtgccat gctccttctc ttaccccaga caggactgga ccggctctac acccgcctac      120

ggctattggt ttaaggccgt gaccgagaca acaaagggcg cccctgtggc cacaaaccac      180

cagagcagag aggtggagat gtccacccgg ggcagattcc agctgacagg cgaccccgcc      240

aagggcaatt gtagcctggt catcagggac gcccagatgc aggatgagtc tcagtacttc      300

tttagggtgg agcgcggcag ctacgtgcgc tataacttta tgaatgatgg cttctttctg      360

aaggtgaccg ccctgacaca gaag                                             384


<210>  129
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>   Siglec 10 full ECD, AA 17-550 (Q96LC7-1 Uniprot) AA SEQUENCE

<400>  129

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn 
    530                 


<210>  130
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>   TIGIT, AA 22-134 NO MUTATIONS (Q495A1 Uniprot ID) AA SEQUENCE

<400>  130

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


<210>  131
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>   TIGIT, ECD AA 22-141 NO MUTATIONS (Q495A1 Uniprot ID) NA 
       SEQUENCE

<400>  131
atgaccggca caatcgagac aacaggcaac atctctgccg agaagggagg cagcatcatc       60

ctgcagtgcc acctgagcag caccacagcc caggtgaccc aggtgaactg ggagcagcag      120

gaccagctgc tggccatctg caatgccgat ctgggctggc acatcagccc ctcctttaag      180

gatagggtgg cacctggacc aggcctgggc ctgaccctgc agagcctgac cgtgaatgac      240

acaggcgagt acttctgtat ctaccacaca tatcctgatg gcacctatac aggcagaatc      300

tttctggagg tgctggagtc tagcgtggcc gagcac                                336


<210>  132
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>   TIGIT, AA 22-134 plus I42A C69S (Q495A1 Uniprot ID) AA SEQUENCE

<400>  132

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ala Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Ser Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


<210>  133
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>   TIGIT, AA 22-134 plus I42A C69S (Q495A1 Uniprot ID) NA SEQUENCE

<400>  133
atgaccggca caatcgagac aacaggcaac atctctgccg agaagggagg cagcatcgcc       60

ctgcagtgcc acctgagcag caccacagcc caggtgaccc aggtgaactg ggagcagcag      120

gaccagctgc tggccatctc caatgccgat ctgggctggc acatcagccc ctcctttaag      180

gatagggtgg cacctggacc aggcctgggc ctgaccctgc agagcctgac cgtgaatgac      240

acaggcgagt acttctgtat ctaccacaca tatcctgatg gcacctatac aggcagaatc      300

tttctggagg tgctggagtc tagcgtggcc gagcac                                336


<210>  134
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LINKER amino acid sequence

<400>  134

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  135
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LINKER amino acid sequence

<400>  135

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  136
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LINKER amino acid sequence

<400>  136

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LINKER amino acid sequence

<400>  137

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  138
<211>  642
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-4 Fc IgG4 Knob: in TSP 214 and 215 217  218 221 and 
       222 AA SEQUENCE

<400>  138

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys 
                405                 410                 415     


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
            420                 425                 430         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        435                 440                 445             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    450                 455                 460                 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
465                 470                 475                 480 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                485                 490                 495     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            500                 505                 510         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        515                 520                 525             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
    530                 535                 540                 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
545                 550                 555                 560 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                565                 570                 575     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            580                 585                 590         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
        595                 600                 605             


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    610                 615                 620                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
625                 630                 635                 640 


Gly Lys 
        


<210>  139
<211>  1926
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-4 Fc IgG4 Knob: in TSP 214 and 215 217  218 221 and 
       222 NA SEQUENCE

<400>  139
cagaccggca caatccccaa gcctaccctg tgggccgagc cagatagcgt gatcacccag       60

ggctcccccg tgacactgtc ttgccagggc agcctggagg cacaggagta ccggctgtat      120

agagagaaga agagcgcctc ctggatcacc cggatcagac ccgagctggt gaagaacggc      180

cagtttcaca tcccttccat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

tctcgggcca gatggagcga gctgtccgac cccctggtgc tggtcatgac cggcgcctat      300

ccaaagccca cactgtccgc ccagccttct ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcaccccc agtgtctgaa tagccagcct cacgcccggg gcagctccag agccatcttc      480

tctgtgggcc ctgtgagccc aaaccggaga tggtcccaca ggtgctacgg ctatgacctg      540

aacagcccat acgtgtggtc tagcccctct gatctgctgg agctgctggt gcctggcgtg      600

agcaagaagc catctctgag cgtgcagcca ggccctgtgg tggcacctgg cgagtctctg      660

accctgcagt gcgtgagcga cgtgggctac gatcggttcg tgctgtataa ggagggagag      720

agggatctga ggcagctgcc aggcagacag cctcaggcag gactgtccca ggcaaacttt      780

acactgggcc ccgtgagccg gagctacggc ggacagtacc gctgctatgg agcacacaat      840

ctgtcctctg agtgttctgc ccccagcgac cccctggaca tcctgatcac cggccagatc      900

aggggcacac cattcatcag cgtgcagcca ggaccaaccg tggcctccgg cgagaacgtg      960

acactgctgt gccagagctg gcgccagttc cacacctttc tgctgacaaa ggcaggagca     1020

gcagacgcac ctctgaggct gcgctccatc cacgagtacc caaagtatca ggccgagttt     1080

ccaatgagcc ccgtgacctc cgcccacgca ggcacataca gatgctatgg cagcctgaac     1140

agcgacccct acctgctgag ccacccttcc gagccactgg agctggtggt gtccggcggc     1200

ggcggctctg gcggaggagg cagcggagga ggaggatccg agtctaagta cggaccacca     1260

tgccctccat gtcctgcacc agagttcgag ggaggaccat ccgtgttcct gtttccacct     1320

aagcctaagg acaccctgat gatctccaga acccccgagg tgacatgcgt ggtggtggac     1380

gtgtctcagg aggatcctga ggtgcagttc aattggtacg tggatggcgt ggaggtgcac     1440

aacgccaaga caaagccccg ggaggagcag tttaatagca cctacagagt ggtgtccgtg     1500

ctgacagtgc tgcaccagga ttggctgaat ggcaaggagt ataagtgtaa ggtgagcaac     1560

aagggcctgc ctagctccat cgagaagacc atctccaagg ccaagggcca gccaagagag     1620

ccacaggtgt gcaccctgcc accaagccag gaggagatga caaagaatca ggtgtccctg     1680

tggtgtctgg tgaagggctt ctacccttcc gacatcgccg tggagtggga gtctaacggc     1740

cagccagaga acaattacaa gaccacacct ccagtgctgg actctgatgg cagcttcttt     1800

ctgtattctc ggctgaccgt ggataagagc agatggcagg agggcaacgt gttcagctgc     1860

tccgtgatgc acgaggccct gcacaaccac tatacacaga agtctctgag cctgtccctg     1920

ggcaag                                                                1926


<210>  140
<211>  442
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-2 Fc IgG4 Knob: in TSP 214 V1 and 215 V1 AA SEQUENCE

<400>  140

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  141
<211>  1326
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-2 Fc IgG4 Knob: in TSP 214 V1 and 215 V1 NA SEQUENCE

<400>  141
cagaccggca caatccccaa gcctaccctg tgggccgagc cagatagcgt gatcacccag       60

ggctcccccg tgacactgtc ttgccagggc agcctggagg cacaggagta ccggctgtat      120

agagagaaga agagcgcctc ctggatcacc cggatcagac ccgagctggt gaagaacggc      180

cagtttcaca tcccttccat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

tctcgggcca gatggagcga gctgtccgac cccctggtgc tggtcatgac cggcgcctat      300

ccaaagccca cactgtccgc ccagccttct ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcaccccc agtgtctgaa tagccagcct cacgcccggg gcagctccag agccatcttc      480

tctgtgggcc ctgtgagccc aaaccggaga tggtcccaca ggtgctacgg ctatgacctg      540

aacagcccat acgtgtggtc tagcccctct gatctgctgg agctgctggt gcctggcggc      600

ggcggctctg gcggaggagg cagcggagga ggaggatccg agtctaagta cggaccacca      660

tgccctccat gtcctgcacc agagttcgag ggaggaccat ccgtgttcct gtttccacct      720

aagcctaagg acaccctgat gatctccaga acccccgagg tgacatgcgt ggtggtggac      780

gtgtctcagg aggatcctga ggtgcagttc aattggtacg tggatggcgt ggaggtgcac      840

aacgccaaga caaagccccg ggaggagcag tttaatagca cctacagagt ggtgtccgtg      900

ctgacagtgc tgcaccagga ttggctgaat ggcaaggagt ataagtgtaa ggtgagcaac      960

aagggcctgc ctagctccat cgagaagacc atctccaagg ccaagggcca gccaagagag     1020

ccacaggtgt gcaccctgcc accaagccag gaggagatga caaagaatca ggtgtccctg     1080

tggtgtctgg tgaagggctt ctacccttcc gacatcgccg tggagtggga gtctaacggc     1140

cagccagaga acaattacaa gaccacacct ccagtgctgg actctgatgg cagcttcttt     1200

ctgtattctc ggctgaccgt ggataagagc agatggcagg agggcaacgt gttcagctgc     1260

tccgtgatgc acgaggccct gcacaaccac tatacacaga agtctctgag cctgtccctg     1320

ggcaag                                                                1326


<210>  142
<211>  1252
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-4 -Fc IgG4 Hole-sc3x41BBL: in DSP 214 AA SEQUENCE

<400>  142

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys 
                405                 410                 415     


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
            420                 425                 430         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        435                 440                 445             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    450                 455                 460                 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
465                 470                 475                 480 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                485                 490                 495     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            500                 505                 510         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        515                 520                 525             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    530                 535                 540                 


Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys Asn Gln Val Ser Leu 
545                 550                 555                 560 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                565                 570                 575     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            580                 585                 590         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp 
        595                 600                 605             


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    610                 615                 620                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
625                 630                 635                 640 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro 
                645                 650                 655     


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
            660                 665                 670         


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
        675                 680                 685             


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
    690                 695                 700                 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
705                 710                 715                 720 


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                725                 730                 735     


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
            740                 745                 750         


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
        755                 760                 765             


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
    770                 775                 780                 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
785                 790                 795                 800 


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
                805                 810                 815     


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
            820                 825                 830         


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly 
        835                 840                 845             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg 
    850                 855                 860                 


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
865                 870                 875                 880 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                885                 890                 895     


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            900                 905                 910         


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        915                 920                 925             


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    930                 935                 940                 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
945                 950                 955                 960 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                965                 970                 975     


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            980                 985                 990         


Gln Gly Arg Leu Leu His Leu Ser  Ala Gly Gln Arg Leu  Gly Val His 
        995                 1000                 1005             


Leu His  Thr Glu Ala Arg Ala  Arg His Ala Trp Gln  Leu Thr Gln 
    1010                 1015                 1020             


Gly Ala  Thr Val Leu Gly Leu  Phe Arg Val Thr Pro  Glu Ile Pro 
    1025                 1030                 1035             


Ala Gly  Leu Pro Ser Pro Arg  Ser Glu Gly Gly Gly  Gly Ser Gly 
    1040                 1045                 1050             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala Ala Ser  Pro Arg Leu 
    1055                 1060                 1065             


Arg Glu  Gly Pro Glu Leu Ser  Pro Asp Asp Pro Ala  Gly Leu Leu 
    1070                 1075                 1080             


Asp Leu  Arg Gln Gly Met Phe  Ala Gln Leu Val Ala  Gln Asn Val 
    1085                 1090                 1095             


Leu Leu  Ile Asp Gly Pro Leu  Ser Trp Tyr Ser Asp  Pro Gly Leu 
    1100                 1105                 1110             


Ala Gly  Val Ser Leu Thr Gly  Gly Leu Ser Tyr Lys  Glu Asp Thr 
    1115                 1120                 1125             


Lys Glu  Leu Val Val Ala Lys  Ala Gly Val Tyr Tyr  Val Phe Phe 
    1130                 1135                 1140             


Gln Leu  Glu Leu Arg Arg Val  Val Ala Gly Glu Gly  Ser Gly Ser 
    1145                 1150                 1155             


Val Ser  Leu Ala Leu His Leu  Gln Pro Leu Arg Ser  Ala Ala Gly 
    1160                 1165                 1170             


Ala Ala  Ala Leu Ala Leu Thr  Val Asp Leu Pro Pro  Ala Ser Ser 
    1175                 1180                 1185             


Glu Ala  Arg Asn Ser Ala Phe  Gly Phe Gln Gly Arg  Leu Leu His 
    1190                 1195                 1200             


Leu Ser  Ala Gly Gln Arg Leu  Gly Val His Leu His  Thr Glu Ala 
    1205                 1210                 1215             


Arg Ala  Arg His Ala Trp Gln  Leu Thr Gln Gly Ala  Thr Val Leu 
    1220                 1225                 1230             


Gly Leu  Phe Arg Val Thr Pro  Glu Ile Pro Ala Gly  Leu Pro Ser 
    1235                 1240                 1245             


Pro Arg  Ser Glu 
    1250         


<210>  143
<211>  3756
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-4 -Fc IgG4 Hole-sc3x41BBL: in DSP 214 AA SEQUENCE NA 
       SEQUENCE

<400>  143
cagaccggca caatccccaa gcctaccctg tgggccgagc cagatagcgt gatcacccag       60

ggctcccccg tgacactgtc ttgccagggc agcctggagg cacaggagta ccggctgtat      120

agagagaaga agagcgcctc ctggatcacc cggatcagac ccgagctggt gaagaacggc      180

cagtttcaca tcccttccat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

tctcgggcca gatggagcga gctgtccgac cccctggtgc tggtcatgac cggcgcctat      300

ccaaagccca cactgtccgc ccagccttct ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcaccccc agtgtctgaa tagccagcct cacgcccggg gcagctccag agccatcttc      480

tctgtgggcc ctgtgagccc aaaccggaga tggtcccaca ggtgctacgg ctatgacctg      540

aacagcccat acgtgtggtc tagcccctct gatctgctgg agctgctggt gcctggcgtg      600

agcaagaagc catctctgag cgtgcagcca ggccctgtgg tggcacctgg cgagtctctg      660

accctgcagt gcgtgagcga cgtgggctac gatcggttcg tgctgtataa ggagggagag      720

agggatctga ggcagctgcc aggcagacag cctcaggcag gactgtccca ggcaaacttt      780

acactgggcc ccgtgagccg gagctacggc ggacagtacc gctgctatgg agcacacaat      840

ctgtcctctg agtgttctgc ccccagcgac cccctggaca tcctgatcac cggccagatc      900

aggggcacac cattcatcag cgtgcagcca ggaccaaccg tggcctccgg cgagaacgtg      960

acactgctgt gccagagctg gcgccagttc cacacctttc tgctgacaaa ggcaggagca     1020

gcagacgcac ctctgaggct gcgctccatc cacgagtacc caaagtatca ggccgagttt     1080

ccaatgagcc ccgtgacctc cgcccacgca ggcacataca gatgctatgg cagcctgaac     1140

agcgacccct acctgctgag ccacccttcc gagccactgg agctggtggt gtccggcggc     1200

ggcggctctg gaggaggagg atccggagga ggaggatccg agtctaagta tggaccacca     1260

tgccctccat gtccagcacc tgagtttgag ggaggacctt ccgtgttcct gtttccccct     1320

aagccaaagg acacactgat gatctccagg acaccagagg tgacctgcgt ggtggtggac     1380

gtgtctcagg aggatcccga ggtgcagttc aactggtacg tggatggcgt ggaggtgcac     1440

aatgccaaga ccaagcctag ggaggagcag tttaactcca cataccgcgt ggtgtctgtg     1500

ctgaccgtgc tgcaccagga ttggctgaac ggcaaggagt ataagtgtaa ggtgagcaat     1560

aagggcctgc caagctccat cgagaagacc atctccaagg caaagggaca gccaagggag     1620

cctcaggtgt atacactgcc acccagccag tgcgagatga ccaagaacca ggtgagcctg     1680

tcctgtgccg tgaagggctt ctacccatct gacatcgccg tggagtggga gagcaatggc     1740

cagcccgaga acaattataa gaccacacct ccagtgctgg actccgatgg ctctttcttt     1800

ctggtgtcca ggctgacagt ggataagtct cgctggcagg agggcaacgt gttttcttgt     1860

agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgtc tctgagcctg     1920

ggcaagggcg gcggcggctc cggaggagga ggaagcgccg cctcccctag gctgcgcgag     1980

ggaccagagc tgagcccaga cgatccagca ggactgctgg acctgaggca gggaatgttc     2040

gcacagctgg tggcccagaa cgtgctgctg atcgacggcc ctctgtcttg gtacagcgat     2100

ccaggactgg caggcgtgag cctgacaggc ggactgtcct ataaggagga taccaaggag     2160

ctggtggtgg caaaggcagg cgtgtactac gtgttcttcc agctggagct gaggagagtg     2220

gtggcaggag agggatccgg atctgtgagc ctggccctgc acctgcagcc actgcggagc     2280

gccgcaggag cagccgccct ggccctgacc gtggacctgc cacctgcatc tagcgaggca     2340

cggaattctg ccttcggctt tcagggcaga ctgctgcacc tgagcgccgg acagaggctg     2400

ggagtgcacc tgcacacaga ggcaagggca agacacgcat ggcagctgac acagggagca     2460

accgtgctgg gactgttccg cgtgacccct gagatcccag caggactgcc atccccccgg     2520

tctgagggcg gcggcgggtc cggaggagga ggatctggcg gcggcggcag cgccgcctcc     2580

cccaggctgc gcgagggacc tgagctgtcc ccagacgatc ctgccggcct gctggacctg     2640

agacagggaa tgtttgccca gctggtcgct cagaacgtgc tgctgattga cggccccctg     2700

tcctggtata gcgatcctgg actggcaggc gtgtctctga caggcggact gagttacaaa     2760

gaagacacta aagaactggt cgtcgccaaa gccggcgtgt actacgtgtt cttccaactg     2820

gagctgagga gggtcgtcgc cggcgaaggc agcggctctg tgagcctggc cctgcacctg     2880

caaccactga ggagcgccgc cggcgccgcc gccctggccc tgactgtgga cctgccacca     2940

gcatcctctg aggcaaggaa ttccgccttc ggcttccagg gccggctgct gcacctgtct     3000

gccggacaga gactgggcgt ccacctgcat accgaagcca gagccaggca tgcctggcag     3060

ctgacccagg gcgccaccgt gctgggcctg ttcagagtga ccccagaaat tccagcagga     3120

ctgccttccc caaggtctga gggaggagga ggaagtggcg gaggaggatc cggaggggga     3180

gggagcgccg cctccccaag actgagagag ggaccagagc tgtcccctga tgaccctgcc     3240

gggctgctgg acctgagaca aggcatgttc gcccagctgg tcgcacaaaa cgtgctgtta     3300

attgacggcc cactgtcctg gtattccgac cctggcctgg ccggcgtgtc cctgacaggc     3360

ggcctgtctt acaaagaaga cacaaaagaa ctggtcgtcg ctaaagctgg cgtgtactac     3420

gtgttcttcc aattagaact gagaagggtc gtcgccggcg agggcagcgg gtctgtgagc     3480

ctggccctgc acctgcaacc gctgcggagc gccgccggcg ctgccgccct ggccctgaca     3540

gtggacctgc ctccagcaag ctccgaggca aggaatagcg ccttcggctt tcaaggccgc     3600

ctgctgcacc tgtccgccgg acagcggctg ggcgtccacc tgcacaccga agccagagcc     3660

cgccatgcct ggcagctgac tcagggcgct accgtgctgg gcctgttccg cgtgacccca     3720

gagatccctg ccggcctgcc ctcccctcgg tctgag                               3756


<210>  144
<211>  1052
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-2- Fc IgG4 Hole- sc3x41BBL: in DSP 214 V1 AA SEQUENCE

<400>  144

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
    450                 455                 460                 


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
465                 470                 475                 480 


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
                485                 490                 495     


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
            500                 505                 510         


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
        515                 520                 525             


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
    530                 535                 540                 


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
545                 550                 555                 560 


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
                565                 570                 575     


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
            580                 585                 590         


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
        595                 600                 605             


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
    610                 615                 620                 


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
625                 630                 635                 640 


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
            660                 665                 670         


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
        675                 680                 685             


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
    690                 695                 700                 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
705                 710                 715                 720 


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                725                 730                 735     


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
            740                 745                 750         


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
        755                 760                 765             


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
    770                 775                 780                 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
785                 790                 795                 800 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                805                 810                 815     


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
            820                 825                 830         


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
        835                 840                 845             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala 
    850                 855                 860                 


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
865                 870                 875                 880 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                885                 890                 895     


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            900                 905                 910         


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        915                 920                 925             


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    930                 935                 940                 


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
945                 950                 955                 960 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                965                 970                 975     


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            980                 985                 990         


Ser Ala Phe Gly Phe Gln Gly Arg  Leu Leu His Leu Ser  Ala Gly Gln 
        995                 1000                 1005             


Arg Leu  Gly Val His Leu His  Thr Glu Ala Arg Ala  Arg His Ala 
    1010                 1015                 1020             


Trp Gln  Leu Thr Gln Gly Ala  Thr Val Leu Gly Leu  Phe Arg Val 
    1025                 1030                 1035             


Thr Pro  Glu Ile Pro Ala Gly  Leu Pro Ser Pro Arg  Ser Glu 
    1040                 1045                 1050         


<210>  145
<211>  3156
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2 D1-2- Fc IgG4 Hole- sc3x41BBL: in DSP 214 V1 NA SEQUENCE

<400>  145
cagaccggca caatccccaa gcctaccctg tgggccgagc cagatagcgt gatcacccag       60

ggctcccccg tgacactgtc ttgccagggc agcctggagg cacaggagta ccggctgtat      120

agagagaaga agagcgcctc ctggatcacc cggatcagac ccgagctggt gaagaacggc      180

cagtttcaca tcccttccat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

tctcgggcca gatggagcga gctgtccgac cccctggtgc tggtcatgac cggcgcctat      300

ccaaagccca cactgtccgc ccagccttct ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcaccccc agtgtctgaa tagccagcct cacgcccggg gcagctccag agccatcttc      480

tctgtgggcc ctgtgagccc aaaccggaga tggtcccaca ggtgctacgg ctatgacctg      540

aacagcccat acgtgtggtc tagcccctct gatctgctgg agctgctggt gcctggcggc      600

ggcggctctg gaggaggagg atccggagga ggaggatccg agtctaagta tggaccacca      660

tgccctccat gtccagcacc tgagtttgag ggaggacctt ccgtgttcct gtttccccct      720

aagccaaagg acacactgat gatctccagg acaccagagg tgacctgcgt ggtggtggac      780

gtgtctcagg aggatcccga ggtgcagttc aactggtacg tggatggcgt ggaggtgcac      840

aatgccaaga ccaagcctag ggaggagcag tttaactcca cataccgcgt ggtgtctgtg      900

ctgaccgtgc tgcaccagga ttggctgaac ggcaaggagt ataagtgtaa ggtgagcaat      960

aagggcctgc caagctccat cgagaagacc atctccaagg caaagggaca gccaagggag     1020

cctcaggtgt atacactgcc acccagccag tgcgagatga ccaagaacca ggtgagcctg     1080

tcctgtgccg tgaagggctt ctacccatct gacatcgccg tggagtggga gagcaatggc     1140

cagcccgaga acaattataa gaccacacct ccagtgctgg actccgatgg ctctttcttt     1200

ctggtgtcca ggctgacagt ggataagtct cgctggcagg agggcaacgt gttttcttgt     1260

agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgtc tctgagcctg     1320

ggcaagggcg gcggcggctc cggaggagga ggaagcgccg cctcccctag gctgcgcgag     1380

ggaccagagc tgagcccaga cgatccagca ggactgctgg acctgaggca gggaatgttc     1440

gcacagctgg tggcccagaa cgtgctgctg atcgacggcc ctctgtcttg gtacagcgat     1500

ccaggactgg caggcgtgag cctgacaggc ggactgtcct ataaggagga taccaaggag     1560

ctggtggtgg caaaggcagg cgtgtactac gtgttcttcc agctggagct gaggagagtg     1620

gtggcaggag agggatccgg atctgtgagc ctggccctgc acctgcagcc actgcggagc     1680

gccgcaggag cagccgccct ggccctgacc gtggacctgc cacctgcatc tagcgaggca     1740

cggaattctg ccttcggctt tcagggcaga ctgctgcacc tgagcgccgg acagaggctg     1800

ggagtgcacc tgcacacaga ggcaagggca agacacgcat ggcagctgac acagggagca     1860

accgtgctgg gactgttccg cgtgacccct gagatcccag caggactgcc atccccccgg     1920

tctgagggcg gcggcgggtc cggaggagga ggatctggcg gcggcggcag cgccgcctcc     1980

cccaggctgc gcgagggacc tgagctgtcc ccagacgatc ctgccggcct gctggacctg     2040

agacagggaa tgtttgccca gctggtcgct cagaacgtgc tgctgattga cggccccctg     2100

tcctggtata gcgatcctgg actggcaggc gtgtctctga caggcggact gagttacaaa     2160

gaagacacta aagaactggt cgtcgccaaa gccggcgtgt actacgtgtt cttccaactg     2220

gagctgagga gggtcgtcgc cggcgaaggc agcggctctg tgagcctggc cctgcacctg     2280

caaccactga ggagcgccgc cggcgccgcc gccctggccc tgactgtgga cctgccacca     2340

gcatcctctg aggcaaggaa ttccgccttc ggcttccagg gccggctgct gcacctgtct     2400

gccggacaga gactgggcgt ccacctgcat accgaagcca gagccaggca tgcctggcag     2460

ctgacccagg gcgccaccgt gctgggcctg ttcagagtga ccccagaaat tccagcagga     2520

ctgccttccc caaggtctga gggaggagga ggaagtggcg gaggaggatc cggaggggga     2580

gggagcgccg cctccccaag actgagagag ggaccagagc tgtcccctga tgaccctgcc     2640

gggctgctgg acctgagaca aggcatgttc gcccagctgg tcgcacaaaa cgtgctgtta     2700

attgacggcc cactgtcctg gtattccgac cctggcctgg ccggcgtgtc cctgacaggc     2760

ggcctgtctt acaaagaaga cacaaaagaa ctggtcgtcg ctaaagctgg cgtgtactac     2820

gtgttcttcc aattagaact gagaagggtc gtcgccggcg agggcagcgg gtctgtgagc     2880

ctggccctgc acctgcaacc gctgcggagc gccgccggcg ctgccgccct ggccctgaca     2940

gtggacctgc ctccagcaag ctccgaggca aggaatagcg ccttcggctt tcaaggccgc     3000

ctgctgcacc tgtccgccgg acagcggctg ggcgtccacc tgcacaccga agccagagcc     3060

cgccatgcct ggcagctgac tcagggcgct accgtgctgg gcctgttccg cgtgacccca     3120

gagatccctg ccggcctgcc ctcccctcgg tctgag                               3156


<210>  146
<211>  1076
<212>  PRT
<213>  Artificial sequence

<220>
<223>   SIRPa -Fc Hole IgG4- sc3xCD40L: in TSP 112 and 217 AA SEQUENCE

<400>  146

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    450                 455                 460                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn 
        595                 600                 605             


Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr 
    610                 615                 620                 


Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn 
625                 630                 635                 640 


Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly 
                645                 650                 655     


Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala 
            660                 665                 670         


Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly 
        675                 680                 685             


Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala 
    690                 695                 700                 


Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu 
705                 710                 715                 720 


Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val 
                725                 730                 735     


Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly 
            740                 745                 750         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Lys Gly 
        755                 760                 765             


Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser 
    770                 775                 780                 


Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met 
785                 790                 795                 800 


Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys 
                805                 810                 815     


Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn 
            820                 825                 830         


Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Ser Leu Lys 
        835                 840                 845             


Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His 
    850                 855                 860                 


Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val 
865                 870                 875                 880 


Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro 
                885                 890                 895     


Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys 
            900                 905                 910         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        915                 920                 925             


Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
    930                 935                 940                 


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
945                 950                 955                 960 


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
                965                 970                 975     


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
            980                 985                 990         


Cys Ser Asn Arg Glu Ala Ser Ser  Gln Ala Pro Phe Ile  Ala Ser Leu 
        995                 1000                 1005             


Ser Leu  Lys Ser Pro Gly Arg  Phe Glu Arg Ile Leu  Leu Arg Ala 
    1010                 1015                 1020             


Ala Asn  Thr His Ser Ser Ala  Lys Pro Cys Gly Gln  Gln Ser Ile 
    1025                 1030                 1035             


His Leu  Gly Gly Val Phe Glu  Leu Gln Pro Gly Ala  Ser Val Phe 
    1040                 1045                 1050             


Val Asn  Val Thr Asp Pro Ser  Gln Val Ser His Gly  Thr Gly Phe 
    1055                 1060                 1065             


Thr Ser  Phe Gly Leu Leu Lys  Leu 
    1070                 1075     


<210>  147
<211>  3228
<212>  DNA
<213>  Artificial sequence

<220>
<223>   SIRPa -Fc Hole IgG4- sc3xCD40L: in TSP 112 and 217 NA SEQUENCE

<400>  147
gaggaggagc tgcaggtcat ccagcctgat aagtctgtgc tggtggcagc aggagagaca       60

gccacactgc ggtgcaccgc cacaagcctg atcccagtgg gccccatcca gtggttcagg      120

ggagcaggac ctggaaggga gctgatctac aaccagaagg agggccactt tccaagagtg      180

accacagtgt ccgacctgac caagcggaac aatatggatt tctctatcag aatcggcaat      240

atcacacctg ccgacgccgg cacctactat tgcgtgaagt tcaggaaggg ctccccagac      300

gatgtggagt ttaagagcgg agcaggcacc gagctgtccg tgagggccaa gccttctgcc      360

ccagtggtga gcggaccagc agccagagcc accccacagc acacagtgag cttcacctgt      420

gagagccacg gcttttcccc ccgggacatc accctgaagt ggttcaagaa cggcaatgag      480

ctgtccgact ttcagaccaa cgtggacccc gtgggcgagt ctgtgagcta ttccatccac      540

tctacagcca aggtggtgct gacccgcgag gacgtgcaca gccaggtcat ctgcgaggtg      600

gcacacgtga ccctgcaggg cgatcccctg aggggcacag ccaatctgag cgagacaatc      660

agagtgcccc ctacactgga ggtgacccag cagcccgtgc gcgcagagaa ccaagtgaat      720

gtgacatgtc aggtgcggaa gttctaccct cagagactgc agctgacctg gctggagaac      780

ggcaacgtga gccggaccga gacagccagc accgtgacag agaacaagga cggcacatat      840

aattggatgt cttggctgct ggtgaacgtg agcgcccaca gggacgatgt gaagctgacc      900

tgccaggtgg agcacgacgg acagccagcc gtgtctaaga gccacgatct gaaggtgagc      960

gcccacccta aggagcaggg ctccaacaca gccgccgaga ataccggcag caacgagcgg     1020

aatatctacg gaggaggagg ctccggagga ggaggctccg agtctaagta tggaccacca     1080

tgccctccat gtccagcacc tgagttcgag ggaggaccta gcgtgttcct gtttccccct     1140

aagccaaagg acaccctgat gatctccaga acaccagagg tgacctgcgt ggtggtggac     1200

gtgtctcagg aggaccccga ggtgcagttt aactggtacg tggatggcgt ggaggtgcac     1260

aatgccaaga ccaagccccg ggaggagcag ttcaattcca cataccgcgt ggtgtctgtg     1320

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt ataagtgtaa ggtgagcaat     1380

aagggcctgc caagctccat cgagaaaacc atcagcaagg caaagggaca gccccgggag     1440

cctcaggtgt atacactgcc accctcccag tgcgagatga ccaagaacca ggtgagcctg     1500

tcctgtgccg tgaagggctt ttacccatct gacatcgccg tggagtggga gagcaatggc     1560

cagcccgaga acaattataa gaccacacct ccagtgctgg actccgatgg ctctttcttt     1620

ctggtgtcca ggctgacagt ggataagtct cgctggcagg agggcaacgt gttctcttgt     1680

agcgtgatgc acgaggccct gcacaatcac tacacccaaa agtccctgtc tctgagcctg     1740

ggcaagggcg gcggcggctc cggcggagga ggctctggcg gcggcggcag cggaggcggc     1800

ggctcccaga agggcgatca gaacccccag atcgccgccc acgtgatctc cgaggcctct     1860

agcaagacca catctgtgct gcagtgggcc gagaagggct actatacaat gagcaacaat     1920

ctggtgaccc tggagaacgg caagcagctg acagtgaagc ggcagggcct gtactatatc     1980

tatgcccagg tgaccttctg ctccaataga gaggcctcct ctcaggcccc ctttatcgcc     2040

tccctgtctc tgaagtctcc tggccggttc gagagaatcc tgctgagggc agcaaacaca     2100

cacagctccg ccaagccctg tggccagcag tctatccacc tgggcggcgt gttcgagctg     2160

cagccaggag ccagcgtgtt tgtgaatgtg accgacccta gccaggtgtc ccacggcacc     2220

ggcttcacca gcttcggcct gctgaagctg ggcggcggcg gctctggcgg aggaggcagc     2280

ggaggaggag gctcccagaa aggcgatcag aaccctcaga ttgctgccca cgtgatcagc     2340

gaggcctcta gcaagaccac atccgtgctg cagtgggctg aaaaaggata ctatacaatg     2400

tctaataatc tggtgaccct ggagaatggc aagcagctga ccgtcaagag acagggcctg     2460

tattatatct acgcccaggt gaccttttgc agcaatcgcg aggcctcctc tcaggctcca     2520

ttcatcgcca gcctgtccct gaagtcccca ggcaggtttg agcgcatcct gctgagagcc     2580

gccaataccc acagctccgc caagccatgt ggacagcagt ccattcacct gggcggcgtg     2640

ttcgagctgc aaccaggagc cagcgtgttc gtgaatgtga ccgacccctc tcaggtgagc     2700

cacggcaccg gcttcaccag cttcggcctg ctgaagctgg gtggaggagg ctctggcggg     2760

ggcggcagcg gcggaggagg ctcccagaag ggcgatcaga atcctcagat tgccgcccac     2820

gtgatctctg aggcctctag caagaccaca agcgtgctgc agtgggcaga aaaagggtac     2880

tatacaatgt ctaacaatct ggtgaccctg gagaacggca agcaactgac cgtcaaaaga     2940

cagggcctgt actacatcta cgctcaggtg accttctgca gcaataggga ggcctcctct     3000

caggcacctt ttatcgcctc tctgagcctg aagtccccag gccggttcga gagaatcctg     3060

ttaagggcag caaacactca cagctccgcc aaaccatgtg gacagcagag catacacctg     3120

ggcggcgtgt tcgagctgca accgggagcc tccgtgtttg tcaatgtgac cgacccatcc     3180

caggtgtctc acggcaccgg cttcaccagc ttcggcctgc tgaagctg                  3228


<210>  148
<211>  1136
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2-Fc -Fc Hole IgG4- sc3xCD40L: in TSP 218 AA SEQUENCE

<400>  148

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys 
                405                 410                 415     


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
            420                 425                 430         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        435                 440                 445             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    450                 455                 460                 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
465                 470                 475                 480 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                485                 490                 495     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            500                 505                 510         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        515                 520                 525             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    530                 535                 540                 


Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys Asn Gln Val Ser Leu 
545                 550                 555                 560 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                565                 570                 575     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            580                 585                 590         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp 
        595                 600                 605             


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    610                 615                 620                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
625                 630                 635                 640 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
            660                 665                 670         


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
        675                 680                 685             


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
    690                 695                 700                 


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
705                 710                 715                 720 


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
                725                 730                 735     


Pro Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg 
            740                 745                 750         


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
        755                 760                 765             


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
    770                 775                 780                 


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
785                 790                 795                 800 


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly 
                805                 810                 815     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro 
            820                 825                 830         


Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser 
        835                 840                 845             


Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu 
    850                 855                 860                 


Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu 
865                 870                 875                 880 


Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser 
                885                 890                 895     


Ser Gln Ala Pro Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg 
            900                 905                 910         


Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys 
        915                 920                 925             


Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln 
    930                 935                 940                 


Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser 
945                 950                 955                 960 


His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp 
            980                 985                 990         


Gln Asn Pro Gln Ile Ala Ala His  Val Ile Ser Glu Ala  Ser Ser Lys 
        995                 1000                 1005             


Thr Thr  Ser Val Leu Gln Trp  Ala Glu Lys Gly Tyr  Tyr Thr Met 
    1010                 1015                 1020             


Ser Asn  Asn Leu Val Thr Leu  Glu Asn Gly Lys Gln  Leu Thr Val 
    1025                 1030                 1035             


Lys Arg  Gln Gly Leu Tyr Tyr  Ile Tyr Ala Gln Val  Thr Phe Cys 
    1040                 1045                 1050             


Ser Asn  Arg Glu Ala Ser Ser  Gln Ala Pro Phe Ile  Ala Ser Leu 
    1055                 1060                 1065             


Ser Leu  Lys Ser Pro Gly Arg  Phe Glu Arg Ile Leu  Leu Arg Ala 
    1070                 1075                 1080             


Ala Asn  Thr His Ser Ser Ala  Lys Pro Cys Gly Gln  Gln Ser Ile 
    1085                 1090                 1095             


His Leu  Gly Gly Val Phe Glu  Leu Gln Pro Gly Ala  Ser Val Phe 
    1100                 1105                 1110             


Val Asn  Val Thr Asp Pro Ser  Gln Val Ser His Gly  Thr Gly Phe 
    1115                 1120                 1125             


Thr Ser  Phe Gly Leu Leu Lys  Leu 
    1130                 1135     


<210>  149
<211>  3408
<212>  DNA
<213>  Artificial sequence

<220>
<223>   LILRB2-Fc -Fc Hole IgG4- sc3xCD40L: in TSP 218 NA SEQUENCE

<400>  149
cagaccggca caatccctaa gccaaccctg tgggccgagc ctgatagcgt gatcacccag       60

ggctccccag tgacactgag ctgccagggc tccctggagg cacaggagta ccggctgtat      120

agagagaaga agtctgccag ctggatcacc cggatcagac ctgagctggt gaagaacggc      180

cagttccaca tcccatctat cacctgggag cacacaggcc ggtacggatg ccagtactat      240

agccgggcca gatggtctga gctgagcgac cccctggtgc tggtcatgac cggagcctat      300

cccaagccta cactgtctgc ccagccaagc ccagtggtga cctctggcgg cagagtgaca      360

ctgcagtgtg agagccaggt ggccttcggc ggctttatcc tgtgcaagga gggcgaggag      420

gagcacccac agtgtctgaa tagccagcca cacgccaggg gcagctcccg cgccatcttc      480

agcgtgggac ccgtgagccc aaaccggaga tggtcccacc gctgctacgg ctatgacctg      540

aacagccctt acgtgtggtc tagcccaagc gatctgctgg agctgctggt gcccggcgtg      600

agcaagaagc cttccctgtc tgtgcagcct ggaccagtgg tggcacctgg agagtccctg      660

accctgcagt gcgtgagcga cgtgggctac gatcggtttg tgctgtataa ggagggagag      720

agggatctga ggcagctgcc aggcagacag ccacaggccg gcctgtccca ggccaacttc      780

accctgggcc cagtgagccg gtcctatggc ggccagtaca gatgctatgg cgcccacaat      840

ctgtcctctg agtgttccgc cccaagcgac cccctggaca tcctgatcac cggccagatc      900

aggggcacac cctttatcag cgtgcagcca ggacctaccg tggcctccgg cgagaacgtg      960

acactgctgt gccagagctg gcgccagttc cacacctttc tgctgacaaa ggcaggagca     1020

gcagacgcac cactgaggct gcgctccatc cacgagtacc ccaagtatca ggccgagttc     1080

ccaatgtccc cagtgacctc tgcccacgca ggcacataca ggtgttatgg cagcctgaac     1140

agcgacccct acctgctgtc tcaccctagc gagccactgg agctggtggt gtctggagga     1200

ggaggcagcg gcggaggagg ctccggaggc ggcggctctg agagcaagta tggaccacct     1260

tgcccaccat gtccagcacc agagttcgag ggaggaccaa gcgtgttcct gtttcctcca     1320

aagcctaagg acaccctgat gatctcccgc acccctgagg tgacatgcgt ggtggtggac     1380

gtgtctcagg aggaccccga ggtgcagttt aactggtacg tggatggcgt ggaggtgcac     1440

aatgccaaga ccaagccccg ggaggagcag ttcaactcta cctacagagt ggtgagcgtg     1500

ctgacagtgc tgcaccagga ctggctgaac ggcaaggagt ataagtgtaa ggtgagcaat     1560

aagggcctgc ctagctccat cgagaaaacc atcagcaagg caaagggaca gcccagggag     1620

cctcaggtgt ataccctgcc cccttcccag tgcgagatga caaagaacca ggtgtccctg     1680

tcttgtgccg tgaagggctt ttacccatcc gacatcgccg tggagtggga gtctaatggc     1740

cagcccgaga acaattataa gaccacacca cccgtgctgg actccgatgg ctctttcttt     1800

ctggtgagca ggctgaccgt ggataagtcc cgctggcagg agggcaacgt gttcagctgc     1860

tccgtgatgc acgaggccct gcacaatcac tacacacaga agtctctgag cctgtccctg     1920

ggcaagggcg gcggcggctc tggcggcggc ggcagcggcg gcggcggctc cggaggaggc     1980

ggctctcaga agggcgatca gaacccccag atcgccgccc acgtgatcag cgaggcctct     2040

agcaagacca catccgtgct gcagtgggcc gagaagggct actataccat gagcaacaat     2100

ctggtgacac tggagaacgg caagcagctg accgtgaaga ggcagggcct gtactatatc     2160

tacgcccagg tgacattctg ctccaatcgc gaggcctcct ctcaggcccc ttttatcgcc     2220

tctctgagcc tgaagtctcc aggccggttc gagagaatcc tgctgagggc agcaaacacc     2280

cacagctccg ccaagccttg tggccagcag tctatccacc tgggcggcgt gttcgagctg     2340

cagccaggag ccagcgtgtt tgtgaatgtg acagacccta gccaggtgtc ccacggcacc     2400

ggcttcacca gcttcggcct gctgaagctg ggcggcggcg gcagcggggg cggcggctcc     2460

ggagggggag gctctcagaa aggcgatcag aatccacaga ttgctgccca cgtgatctct     2520

gaggcctcta gcaagaccac aagcgtgctg cagtgggctg aaaaaggata ctataccatg     2580

tctaataatc tggtgacact ggagaatggc aagcagctga ctgtcaagag acagggcctg     2640

tattacatct acgctcaggt gacattttgc agcaatagag aggcctcctc tcaggctccc     2700

ttcatcgcct ccctgtctct gaagtcccct ggcaggtttg agcgcatcct gctgagagcc     2760

gccaatactc acagctccgc caagccatgt ggacagcagt ccattcacct gggcggcgtg     2820

ttcgagctgc aaccaggagc cagcgtgttc gtgaatgtga cagacccctc tcaggtgagc     2880

cacggcaccg gcttcaccag cttcggcctg ctgaagctgg gtggcggcgg cagcggcggg     2940

ggcggctccg gaggcggagg ctctcagaag ggcgatcaga atcctcagat tgcagcccac     3000

gtgatctccg aggcctctag caagaccaca tctgtgctgc agtgggctga gaaaggctac     3060

tataccatgt ctaacaatct ggtgacactg gagaacggca agcaactgac tgtcaaaaga     3120

cagggcctgt attatatcta cgctcaagtg acattctgca gcaatcggga ggcctcctct     3180

caggcaccct tcatcgccag cctgtccctg aagtcccctg gccggttcga gagaatcctg     3240

ttaagagccg ccaatacaca cagctccgcc aaaccatgtg gacagcagag catacacctg     3300

ggcggcgtgt tcgagctgca accgggagcc tccgtgtttg tcaatgtgac agacccatcc     3360

caggtgtctc acggcaccgg cttcaccagc ttcggcctgc tgaagctg                  3408


<210>  150
<211>  367
<212>  PRT
<213>  Artificial sequence

<220>
<223>   Siglec-Fc Knob IgG4: in TSP 401 and 403 AA SEQUENCE

<400>  150

Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro Glu 
1               5                   10                  15      


Gly Leu Ser Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln Asp 
            20                  25                  30          


Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val Thr 
        35                  40                  45              


Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg Glu 
    50                  55                  60                  


Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro Ala 
65                  70                  75                  80  


Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp Glu 
                85                  90                  95      


Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr Asn 
            100                 105                 110         


Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
    130                 135                 140                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
145                 150                 155                 160 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                165                 170                 175     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            180                 185                 190         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        195                 200                 205             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    210                 215                 220                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
225                 230                 235                 240 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                245                 250                 255     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            260                 265                 270         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        275                 280                 285             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    290                 295                 300                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
305                 310                 315                 320 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                325                 330                 335     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            340                 345                 350         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        355                 360                 365         


<210>  151
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>   Siglec-Fc Knob IgG4: in TSP 401 and 403 NA SEQUENCE

<400>  151
gatggccggt tttggatcag agtgcaggag tccgtgatgg tgcctgaggg cctgtctatc       60

agcgtgccat gctccttctc ttaccccaga caggactgga ccggctctac acccgcctac      120

ggctattggt ttaaggccgt gaccgagaca acaaagggcg cccctgtggc cacaaaccac      180

cagagcagag aggtggagat gtccacccgg ggcagattcc agctgacagg cgaccccgcc      240

aagggcaatt gtagcctggt catcagggac gcccagatgc aggatgagtc tcagtacttc      300

tttagggtgg agcgcggcag ctacgtgcgc tataacttta tgaatgatgg cttctttctg      360

aaggtgaccg ccctgacaca gaagggagga ggaggctccg gcggaggagg cagcgagtcc      420

aagtatggac caccttgccc accatgtcct gcaccagagt tcgagggagg acctagcgtg      480

ttcctgtttc ctccaaagcc aaaggacacc ctgatgatca gcaggactcc tgaggtgaca      540

tgcgtggtgg tggacgtgtc ccaggaggac cccgaggtgc agttcaactg gtatgtggat      600

ggcgtggagg tgcacaatgc caagacaaag ccacgggagg agcagtttaa ctctacctac      660

agagtggtga gcgtgctgac agtgctgcac caggattggc tgaacggcaa ggagtataag      720

tgtaaggtgt ctaataaggg cctgcccagc tccatcgaga aaaccatcag caaggcaaag      780

ggacagcccc gggagcctca ggtgtgcacc ctgccccctt cccaggagga gatgacaaag      840

aaccaggtgt ctctgtggtg tctggtgaag ggcttctacc caagcgacat cgccgtggag      900

tgggagtcca atggccagcc cgagaacaat tacaagacca caccacccgt gctggactcc      960

gatggctctt tctttctgta ttccaggctg accgtggata agtctcgctg gcaggagggc     1020

aacgtgtttt cttgcagcgt gatgcacgag gccctgcaca atcactatac acagaagtcc     1080

ctgtctctga gcctgggcaa g                                               1101


<210>  152
<211>  351
<212>  PRT
<213>  Artificial sequence

<220>
<223>   TIGIT-Fc Knob IgG4: in TSP 501 and 503 AA SEQUENCE

<400>  152

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ala Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Ser Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
        115                 120                 125             


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
                165                 170                 175     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
                245                 250                 255     


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            340                 345                 350     


<210>  153
<211>  1053
<212>  DNA
<213>  Artificial sequence

<220>
<223>   TIGIT-Fc Knob IgG4: in TSP 501 and 503 NA SEQUENCE

<400>  153
atgaccggca caatcgagac aacaggcaac atctctgccg agaagggagg cagcatcgcc       60

ctgcagtgcc acctgagcag caccacagcc caggtgaccc aggtgaactg ggagcagcag      120

gaccagctgc tggccatctc caatgccgat ctgggctggc acatcagccc ctcctttaag      180

gatagggtgg cacctggacc aggcctgggc ctgaccctgc agagcctgac cgtgaatgac      240

acaggcgagt acttctgtat ctaccacaca tatcctgatg gcacctatac aggcagaatc      300

tttctggagg tgctggagtc tagcgtggcc gagcacggag gaggaggctc cggaggagga      360

ggctctgaga gcaagtacgg accaccttgc ccaccatgtc cagcacctga gttcgaggga      420

ggacctagcg tgttcctgtt tcctccaaag ccaaaggaca ccctgatgat cagcaggacc      480

cctgaggtga catgcgtggt ggtggacgtg tcccaggagg accccgaggt gcagttcaac      540

tggtatgtgg atggcgtgga ggtgcacaat gccaagacaa agcccaggga ggagcagttt      600

aactccacct accgcgtggt gtctgtgctg acagtgctgc accaggactg gctgaacggc      660

aaggagtata agtgtaaggt gtctaataag ggcctgccct cctctatcga gaaaaccatc      720

agcaaggcca agggccagcc aagagagcca caggtgtgca ccctgccacc ttcccaggag      780

gagatgacaa agaaccaggt gtctctgtgg tgtctggtga agggcttcta cccatctgac      840

atcgccgtgg agtgggagag caatggccag cccgagaaca attacaagac cacaccaccc      900

gtgctggaca gcgatggctc cttctttctg tatagccggc tgaccgtgga taagtccaga      960

tggcaggagg gcaacgtgtt ttcctgctct gtgatgcacg aggccctgca caatcactat     1020

acacagaaga gcctgtccct gtctctgggc aag                                  1053


<210>  154
<211>  873
<212>  PRT
<213>  Artificial sequence

<220>
<223>   PD1- Fc Hole IgG4-sc3xCD40L: in TSP222 and 403 and 503 AA 
       SEQUENCE

<400>  154

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys 
        275                 280                 285             


Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
385                 390                 395                 400 


Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala 
                405                 410                 415     


Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr 
            420                 425                 430         


Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr 
        435                 440                 445             


Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys 
    450                 455                 460                 


Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Ser 
465                 470                 475                 480 


Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn 
                485                 490                 495     


Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly 
            500                 505                 510         


Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr 
        515                 520                 525             


Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu 
    530                 535                 540                 


Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile 
                565                 570                 575     


Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys 
            580                 585                 590         


Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys 
        595                 600                 605             


Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val 
    610                 615                 620                 


Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala 
625                 630                 635                 640 


Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg 
                645                 650                 655     


Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile 
            660                 665                 670         


His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val 
        675                 680                 685             


Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser 
    690                 695                 700                 


Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala 
                725                 730                 735     


His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp 
            740                 745                 750         


Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu 
        755                 760                 765             


Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr 
    770                 775                 780                 


Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro 
785                 790                 795                 800 


Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile 
                805                 810                 815     


Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln 
            820                 825                 830         


Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser 
        835                 840                 845             


Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly 
    850                 855                 860                 


Phe Thr Ser Phe Gly Leu Leu Lys Leu 
865                 870             


<210>  155
<211>  2619
<212>  DNA
<213>  Artificial sequence

<220>
<223>   PD1- Fc Hole IgG4-sc3xCD40L: in TSP222 and 403 and 503 AA 
       SEQUENCE

<400>  155
gacagcccag atagaccttg gaatccacct accttctccc ccgccctgct ggtggtgaca       60

gagggcgata acgccacctt cacatgctct tttagcaaca cctccgagtc ttttgtgctg      120

aattggtaca ggatgagccc ttccaaccag acagacaagc tggccgcatt ccctgaggac      180

cgctcccagc caggacagga ttctcggttc agagtgaccc agctgccaaa tggccgggac      240

tttcacatga gcgtggtgag agcccggaga aacgattccg gcacatacct gtgcggagcc      300

atctctctgg ccccaaaggc acagatcaag gagtccctgc gggcagagct gagagtgacc      360

gagaggaggg cagaggtgcc cacagcacac ccatctccta gcccacggcc cgcaggacag      420

ggaggaggag gcagcggggg aggaggctcc gagtctaagt acggaccacc atgccctcca      480

tgtcctgcac cagagttcga gggaggacca tccgtgttcc tgtttccacc taagcctaag      540

gacaccctga tgatcagccg gaccccagag gtgacatgcg tggtggtgga cgtgagccag      600

gaggaccccg aggtgcagtt taattggtat gtggatggcg tggaggtgca caacgccaag      660

accaagccca gggaggagca gttcaacagc acctaccgcg tggtgtccgt gctgacagtg      720

ctgcaccagg actggctgaa tggcaaggag tataagtgta aggtgtccaa caagggcctg      780

cctagctcca tcgagaaaac catcagcaag gcaaagggac agccacggga gccacaggtg      840

tacaccctgc caccaagcca gtgcgagatg acaaagaatc aggtgagcct gtcctgtgcc      900

gtgaagggct tttacccttc cgacatcgcc gtggagtggg agtctaacgg ccagccagag      960

aacaattata agaccacacc tccagtgctg gactccgatg gctctttctt tctggtgtct     1020

aggctgaccg tggataagag ccgctggcag gagggcaacg tgttcagctg cagcgtgatg     1080

cacgaggccc tgcacaacca ctatacacaa aagtccctgt ctctgagcct gggcaagggc     1140

ggcggcggca gcggcggagg aggctccgga ggcggcggct ctggcggcgg cggcagccag     1200

aagggcgatc agaatcctca gatcgccgcc cacgtgatca gcgaggcctc tagcaagacc     1260

acatccgtgc tgcagtgggc cgagaagggc tactatacca tgagcaacaa tctggtgaca     1320

ctggagaatg gcaagcagct gaccgtgaag cggcagggcc tgtactatat ctacgcccag     1380

gtgacattct gcagcaacag agaggcctcc tctcaggccc cttttatcgc ctctctgagc     1440

ctgaagtctc caggccggtt cgagagaatc ctgctgaggg cagcaaacac ccacagctcc     1500

gccaagcctt gtggccagca gtctatccac ctgggcggcg tgttcgagct gcagccagga     1560

gccagcgtgt ttgtgaatgt gacagaccct agccaggtgt cccacggcac cggcttcacc     1620

agcttcggcc tgctgaagct gggcggcggc ggcagcgggg gcggcggctc cggaggggga     1680

ggctctcaga aaggcgatca gaatccacag attgctgccc acgtgatctc tgaggcctct     1740

agcaagacca caagcgtgct gcagtgggct gaaaaaggat actataccat gtctaataat     1800

ctggtgacac tggagaatgg caagcagctg actgtcaaga gacagggcct gtattacatc     1860

tacgctcagg tgacattttg cagcaataga gaggcctcct ctcaggctcc cttcatcgcc     1920

tccctgtctc tgaagtcccc tggcaggttt gagcgcatcc tgctgagagc cgccaatact     1980

cacagctccg ccaagccatg tggacagcag tccattcacc tgggcggcgt gttcgagctg     2040

caaccaggag ccagcgtgtt cgtgaatgtg acagacccct ctcaggtgag ccacggcacc     2100

ggcttcacca gcttcggcct gctgaagctg ggtggcggcg gcagcggcgg gggcggctcc     2160

ggaggcggag gctctcagaa gggcgatcag aatcctcaga ttgcagccca cgtgatctcc     2220

gaggcctcta gcaagaccac atctgtgctg cagtgggctg agaaaggcta ctataccatg     2280

tctaacaatc tggtgacact ggagaacggc aagcaactga ctgtcaaaag acagggcctg     2340

tattatatct acgctcaagt gacattctgc agcaatcggg aggcctcctc tcaggcaccc     2400

ttcatcgcca gcctgtccct gaagtcccct ggccggttcg agagaatcct gttaagagcc     2460

gccaatacac acagctccgc caaaccatgt ggacagcaga gcatacacct gggcggcgtg     2520

ttcgagctgc aaccgggagc ctccgtgttt gtcaatgtga cagacccatc ccaggtgtct     2580

cacggcaccg gcttcaccag cttcggcctg ctgaagctg                            2619


<210>  156
<211>  961
<212>  PRT
<213>  Artificial sequence

<220>
<223>   TIGIT-Fc Hole IgG4-sc3x4-1BBL: in TSP 501V1 AA SEQUENCE

<400>  156

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ala Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Ser Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
        115                 120                 125             


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
                165                 170                 175     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Gln Cys Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg 
        355                 360                 365             


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
    370                 375                 380                 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
385                 390                 395                 400 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
                405                 410                 415     


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
            420                 425                 430         


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
        435                 440                 445             


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
    450                 455                 460                 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
465                 470                 475                 480 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                485                 490                 495     


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
            500                 505                 510         


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
        515                 520                 525             


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
    530                 535                 540                 


Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
                565                 570                 575     


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
            580                 585                 590         


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
        595                 600                 605             


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
    610                 615                 620                 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
625                 630                 635                 640 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                645                 650                 655     


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
            660                 665                 670         


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
        675                 680                 685             


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
    690                 695                 700                 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
705                 710                 715                 720 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
                725                 730                 735     


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
            740                 745                 750         


Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        755                 760                 765             


Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser 
    770                 775                 780                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
785                 790                 795                 800 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                805                 810                 815     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            820                 825                 830         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        835                 840                 845             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    850                 855                 860                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
865                 870                 875                 880 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                885                 890                 895     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            900                 905                 910         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        915                 920                 925             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    930                 935                 940                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
945                 950                 955                 960 


Glu 
    


<210>  157
<211>  2883
<212>  DNA
<213>  Artificial sequence

<220>
<223>   TIGIT-Fc Hole IgG4-sc3x4-1BBL: in TSP 501V1 NA SEQUENCE

<400>  157
atgaccggca caatcgagac aacaggcaac atctctgccg agaagggagg cagcatcgcc       60

ctgcagtgcc acctgagcag caccacagcc caggtgaccc aggtgaactg ggagcagcag      120

gaccagctgc tggccatctc caatgccgat ctgggctggc acatcagccc ctcctttaag      180

gatagggtgg cacctggacc aggcctgggc ctgaccctgc agagcctgac cgtgaatgac      240

acaggcgagt acttctgtat ctaccacaca tatcctgatg gcacctatac aggcagaatc      300

tttctggagg tgctggagtc tagcgtggcc gagcacggag gaggaggatc cggaggagga      360

ggatccgagt ctaagtatgg accaccatgc cctccatgtc cagcacctga gtttgaggga      420

ggaccttccg tgttcctgtt tccccctaag ccaaaggaca cactgatgat ctccaggaca      480

ccagaggtga cctgcgtggt ggtggacgtg tctcaggagg atcccgaggt gcagttcaac      540

tggtacgtgg atggcgtgga ggtgcacaat gccaagacca agcctaggga ggagcagttt      600

aactccacat accgcgtggt gtctgtgctg accgtgctgc accaggattg gctgaacggc      660

aaggagtata agtgtaaggt gagcaataag ggcctgccaa gctccatcga gaagaccatc      720

tccaaggcaa agggacagcc aagggagcct caggtgtata cactgccacc cagccagtgc      780

gagatgacca agaaccaggt gagcctgtcc tgtgccgtga agggcttcta cccatctgac      840

atcgccgtgg agtgggagag caatggccag cccgagaaca attataagac cacacctcca      900

gtgctggact ccgatggctc tttctttctg gtgtccaggc tgacagtgga taagtctcgc      960

tggcaggagg gcaacgtgtt ttcttgtagc gtgatgcacg aggccctgca caatcactac     1020

acccagaagt ccctgtctct gagcctgggc aagggcggcg gcggctccgg aggaggagga     1080

agcgccgcct cccctaggct gcgcgaggga ccagagctga gcccagacga tccagcagga     1140

ctgctggacc tgaggcaggg aatgttcgca cagctggtgg cccagaacgt gctgctgatc     1200

gacggccctc tgtcttggta cagcgatcca ggactggcag gcgtgagcct gacaggcgga     1260

ctgtcctata aggaggatac caaggagctg gtggtggcaa aggcaggcgt gtactacgtg     1320

ttcttccagc tggagctgag gagagtggtg gcaggagagg gatccggatc tgtgagcctg     1380

gccctgcacc tgcagccact gcggagcgcc gcaggagcag ccgccctggc cctgaccgtg     1440

gacctgccac ctgcatctag cgaggcacgg aattctgcct tcggctttca gggcagactg     1500

ctgcacctga gcgccggaca gaggctggga gtgcacctgc acacagaggc aagggcaaga     1560

cacgcatggc agctgacaca gggagcaacc gtgctgggac tgttccgcgt gacccctgag     1620

atcccagcag gactgccatc cccccggtct gagggcggcg gcgggtccgg aggaggagga     1680

tctggcggcg gcggcagcgc cgcctccccc aggctgcgcg agggacctga gctgtcccca     1740

gacgatcctg ccggcctgct ggacctgaga cagggaatgt ttgcccagct ggtcgctcag     1800

aacgtgctgc tgattgacgg ccccctgtcc tggtatagcg atcctggact ggcaggcgtg     1860

tctctgacag gcggactgag ttacaaagaa gacactaaag aactggtcgt cgccaaagcc     1920

ggcgtgtact acgtgttctt ccaactggag ctgaggaggg tcgtcgccgg cgaaggcagc     1980

ggctctgtga gcctggccct gcacctgcaa ccactgagga gcgccgccgg cgccgccgcc     2040

ctggccctga ctgtggacct gccaccagca tcctctgagg caaggaattc cgccttcggc     2100

ttccagggcc ggctgctgca cctgtctgcc ggacagagac tgggcgtcca cctgcatacc     2160

gaagccagag ccaggcatgc ctggcagctg acccagggcg ccaccgtgct gggcctgttc     2220

agagtgaccc cagaaattcc agcaggactg ccttccccaa ggtctgaggg aggaggagga     2280

agtggcggag gaggatccgg agggggaggg agcgccgcct ccccaagact gagagaggga     2340

ccagagctgt cccctgatga ccctgccggg ctgctggacc tgagacaagg catgttcgcc     2400

cagctggtcg cacaaaacgt gctgttaatt gacggcccac tgtcctggta ttccgaccct     2460

ggcctggccg gcgtgtccct gacaggcggc ctgtcttaca aagaagacac aaaagaactg     2520

gtcgtcgcta aagctggcgt gtactacgtg ttcttccaat tagaactgag aagggtcgtc     2580

gccggcgagg gcagcgggtc tgtgagcctg gccctgcacc tgcaaccgct gcggagcgcc     2640

gccggcgctg ccgccctggc cctgacagtg gacctgcctc cagcaagctc cgaggcaagg     2700

aatagcgcct tcggctttca aggccgcctg ctgcacctgt ccgccggaca gcggctgggc     2760

gtccacctgc acaccgaagc cagagcccgc catgcctggc agctgactca gggcgctacc     2820

gtgctgggcc tgttccgcgt gaccccagag atccctgccg gcctgccctc ccctcggtct     2880

gag                                                                   2883


<210>  158
<211>  845
<212>  PRT
<213>  Artificial sequence

<220>
<223>   TIGIT-Fc Hole IgG4-sc3xCD40L: in TSP 503V1 AA SEQUENCE

<400>  158

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ala Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Ser Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
        115                 120                 125             


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
                165                 170                 175     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Gln Cys Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
    370                 375                 380                 


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
385                 390                 395                 400 


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
                405                 410                 415     


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
            420                 425                 430         


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
        435                 440                 445             


Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
    450                 455                 460                 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
465                 470                 475                 480 


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
                485                 490                 495     


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
            500                 505                 510         


Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
    530                 535                 540                 


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
545                 550                 555                 560 


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
                565                 570                 575     


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
            580                 585                 590         


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
        595                 600                 605             


Pro Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg Phe Glu Arg 
    610                 615                 620                 


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
625                 630                 635                 640 


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
                645                 650                 655     


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
            660                 665                 670         


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Lys Gly Asp Gln Asn Pro 
    690                 695                 700                 


Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser 
705                 710                 715                 720 


Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu 
                725                 730                 735     


Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu 
            740                 745                 750         


Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser 
        755                 760                 765             


Ser Gln Ala Pro Phe Ile Ala Ser Leu Ser Leu Lys Ser Pro Gly Arg 
    770                 775                 780                 


Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys 
785                 790                 795                 800 


Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln 
                805                 810                 815     


Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser 
            820                 825                 830         


His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
        835                 840                 845 


<210>  159
<211>  2535
<212>  DNA
<213>  Artificial sequence

<220>
<223>   TIGIT-Fc Hole IgG4-sc3xCD40L: in TSP 503V1 AA SEQUENCE

<400>  159
atgaccggca caatcgagac aacaggcaac atctctgccg agaagggagg cagcatcgcc       60

ctgcagtgcc acctgagcag caccacagcc caggtgaccc aggtgaactg ggagcagcag      120

gaccagctgc tggccatctc caatgccgat ctgggctggc acatcagccc ctcctttaag      180

gatagggtgg cacctggacc aggcctgggc ctgaccctgc agagcctgac cgtgaatgac      240

acaggcgagt acttctgtat ctaccacaca tatcctgatg gcacctatac aggcagaatc      300

tttctggagg tgctggagtc tagcgtggcc gagcacggag gaggaggcag cgggggagga      360

ggctccgagt ctaagtacgg accaccatgc cctccatgtc ctgcaccaga gttcgaggga      420

ggaccatccg tgttcctgtt tccacctaag cctaaggaca ccctgatgat cagccggacc      480

ccagaggtga catgcgtggt ggtggacgtg agccaggagg accccgaggt gcagtttaat      540

tggtatgtgg atggcgtgga ggtgcacaac gccaagacca agcccaggga ggagcagttc      600

aacagcacct accgcgtggt gtccgtgctg acagtgctgc accaggactg gctgaatggc      660

aaggagtata agtgtaaggt gtccaacaag ggcctgccta gctccatcga gaaaaccatc      720

agcaaggcaa agggacagcc acgggagcca caggtgtaca ccctgccacc aagccagtgc      780

gagatgacaa agaatcaggt gagcctgtcc tgtgccgtga agggctttta cccttccgac      840

atcgccgtgg agtgggagtc taacggccag ccagagaaca attataagac cacacctcca      900

gtgctggact ccgatggctc tttctttctg gtgtctaggc tgaccgtgga taagagccgc      960

tggcaggagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactat     1020

acacaaaagt ccctgtctct gagcctgggc aagggcggcg gcggcagcgg cggaggaggc     1080

tccggaggcg gcggctctgg cggcggcggc agccagaagg gcgatcagaa tcctcagatc     1140

gccgcccacg tgatcagcga ggcctctagc aagaccacat ccgtgctgca gtgggccgag     1200

aagggctact ataccatgag caacaatctg gtgacactgg agaatggcaa gcagctgacc     1260

gtgaagcggc agggcctgta ctatatctac gcccaggtga cattctgcag caacagagag     1320

gcctcctctc aggccccttt tatcgcctct ctgagcctga agtctccagg ccggttcgag     1380

agaatcctgc tgagggcagc aaacacccac agctccgcca agccttgtgg ccagcagtct     1440

atccacctgg gcggcgtgtt cgagctgcag ccaggagcca gcgtgtttgt gaatgtgaca     1500

gaccctagcc aggtgtccca cggcaccggc ttcaccagct tcggcctgct gaagctgggc     1560

ggcggcggca gcgggggcgg cggctccgga gggggaggct ctcagaaagg cgatcagaat     1620

ccacagattg ctgcccacgt gatctctgag gcctctagca agaccacaag cgtgctgcag     1680

tgggctgaaa aaggatacta taccatgtct aataatctgg tgacactgga gaatggcaag     1740

cagctgactg tcaagagaca gggcctgtat tacatctacg ctcaggtgac attttgcagc     1800

aatagagagg cctcctctca ggctcccttc atcgcctccc tgtctctgaa gtcccctggc     1860

aggtttgagc gcatcctgct gagagccgcc aatactcaca gctccgccaa gccatgtgga     1920

cagcagtcca ttcacctggg cggcgtgttc gagctgcaac caggagccag cgtgttcgtg     1980

aatgtgacag acccctctca ggtgagccac ggcaccggct tcaccagctt cggcctgctg     2040

aagctgggtg gcggcggcag cggcgggggc ggctccggag gcggaggctc tcagaagggc     2100

gatcagaatc ctcagattgc agcccacgtg atctccgagg cctctagcaa gaccacatct     2160

gtgctgcagt gggctgagaa aggctactat accatgtcta acaatctggt gacactggag     2220

aacggcaagc aactgactgt caaaagacag ggcctgtatt atatctacgc tcaagtgaca     2280

ttctgcagca atcgggaggc ctcctctcag gcacccttca tcgccagcct gtccctgaag     2340

tcccctggcc ggttcgagag aatcctgtta agagccgcca atacacacag ctccgccaaa     2400

ccatgtggac agcagagcat acacctgggc ggcgtgttcg agctgcaacc gggagcctcc     2460

gtgtttgtca atgtgacaga cccatcccag gtgtctcacg gcaccggctt caccagcttc     2520

ggcctgctga agctg                                                      2535


<210>  160
<211>  244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TIGIT full length (Q495A1 Uniprot ID) AA SEQUENCE

<400>  160

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  161
<211>  598
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LILRB2 D1-4, full length (Q8N423-1 UniParc) AA SEQUENCE

<400>  161

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Glu Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


<210>  162
<211>  697
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Siglec 10 full length (Q96LC7-1 Uniprot) AA SEQUENCE

<400>  162

Met Leu Leu Pro Leu Leu Leu Ser Ser Leu Leu Gly Gly Ser Gln Ala 
1               5                   10                  15      


Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
            20                  25                  30          


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
        35                  40                  45              


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
    50                  55                  60                  


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
65                  70                  75                  80  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
                85                  90                  95      


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
            100                 105                 110         


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
        115                 120                 125             


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
    130                 135                 140                 


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
145                 150                 155                 160 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
                165                 170                 175     


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
            180                 185                 190         


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
        195                 200                 205             


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
    210                 215                 220                 


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
225                 230                 235                 240 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
                245                 250                 255     


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
            260                 265                 270         


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
        275                 280                 285             


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
    290                 295                 300                 


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
305                 310                 315                 320 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
                325                 330                 335     


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
            340                 345                 350         


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
        355                 360                 365             


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
    370                 375                 380                 


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
385                 390                 395                 400 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
                405                 410                 415     


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
            420                 425                 430         


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
        435                 440                 445             


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
    450                 455                 460                 


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
465                 470                 475                 480 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
                485                 490                 495     


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
            500                 505                 510         


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
        515                 520                 525             


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
    530                 535                 540                 


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
545                 550                 555                 560 


Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Lys Ile Leu Pro Lys 
                565                 570                 575     


Arg Arg Thr Gln Thr Glu Thr Pro Arg Pro Arg Phe Ser Arg His Ser 
            580                 585                 590         


Thr Ile Leu Asp Tyr Ile Asn Val Val Pro Thr Ala Gly Pro Leu Ala 
        595                 600                 605             


Gln Lys Arg Asn Gln Lys Ala Thr Pro Asn Ser Pro Arg Thr Pro Leu 
    610                 615                 620                 


Pro Pro Gly Ala Pro Ser Pro Glu Ser Lys Lys Asn Gln Lys Lys Gln 
625                 630                 635                 640 


Tyr Gln Leu Pro Ser Phe Pro Glu Pro Lys Ser Ser Thr Gln Ala Pro 
                645                 650                 655     


Glu Ser Gln Glu Ser Gln Glu Glu Leu His Tyr Ala Thr Leu Asn Phe 
            660                 665                 670         


Pro Gly Val Arg Pro Arg Pro Glu Ala Arg Met Pro Lys Gly Thr Gln 
        675                 680                 685             


Ala Asp Tyr Ala Glu Val Lys Phe Gln 
    690                 695         


<210>  163
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD40L full length (P29965 Uniprot) AA SEQUENCE

<400>  163

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  164
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TIGIT Full ECD AA SEQUENCE

<400>  164

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  165
<211>  440
<212>  PRT
<213>  Artificial sequence

<220>
<223>   LILRB2 Full ECD AA SEQUENCE

<400>  165

Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Pro 
385                 390                 395                 400 


Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro Ala 
                405                 410                 415     


Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser 
            420                 425                 430         


Gly Leu Gly Arg His Leu Gly Val 
        435                 440 


<210>  166
<211>  1422
<212>  DNA
<213>  Artificial sequence

<220>
<223>   sc3xCD40L, AA 114-261 C194S (P29965 Uniprot) internal linker 
       3x(GGGGS) NA SEQUENCE

<400>  166
cagaagggcg atcagaaccc ccagatcgcc gcccacgtga tctccgaggc ctctagcaag       60

accacatctg tgctgcagtg ggccgagaag ggctactata caatgagcaa caatctggtg      120

accctggaga acggcaagca gctgacagtg aagcggcagg gcctgtacta tatctatgcc      180

caggtgacct tctgctccaa tagagaggcc tcctctcagg ccccctttat cgcctccctg      240

tctctgaagt ctcctggccg gttcgagaga atcctgctga gggcagcaaa cacacacagc      300

tccgccaagc cctgtggcca gcagtctatc cacctgggcg gcgtgttcga gctgcagcca      360

ggagccagcg tgtttgtgaa tgtgaccgac cctagccagg tgtcccacgg caccggcttc      420

accagcttcg gcctgctgaa gctgggcggc ggcggctctg gcggaggagg cagcggagga      480

ggaggctccc agaaaggcga tcagaaccct cagattgctg cccacgtgat cagcgaggcc      540

tctagcaaga ccacatccgt gctgcagtgg gctgaaaaag gatactatac aatgtctaat      600

aatctggtga ccctggagaa tggcaagcag ctgaccgtca agagacaggg cctgtattat      660

atctacgccc aggtgacctt ttgcagcaat cgcgaggcct cctctcaggc tccattcatc      720

gccagcctgt ccctgaagtc cccaggcagg tttgagcgca tcctgctgag agccgccaat      780

acccacagct ccgccaagcc atgtggacag cagtccattc acctgggcgg cgtgttcgag      840

ctgcaaccag gagccagcgt gttcgtgaat gtgaccgacc cctctcaggt gagccacggc      900

accggcttca ccagcttcgg cctgctgaag ctgggtggag gaggctctgg cgggggcggc      960

agcggcggag gaggctccca gaagggcgat cagaatcctc agattgccgc ccacgtgatc     1020

tctgaggcct ctagcaagac cacaagcgtg ctgcagtggg cagaaaaagg gtactataca     1080

atgtctaaca atctggtgac cctggagaac ggcaagcaac tgaccgtcaa aagacagggc     1140

ctgtactaca tctacgctca ggtgaccttc tgcagcaata gggaggcctc ctctcaggca     1200

ccttttatcg cctctctgag cctgaagtcc ccaggccggt tcgagagaat cctgttaagg     1260

gcagcaaaca ctcacagctc cgccaaacca tgtggacagc agagcataca cctgggcggc     1320

gtgttcgagc tgcaaccggg agcctccgtg tttgtcaatg tgaccgaccc atcccaggtg     1380

tctcacggca ccggcttcac cagcttcggc ctgctgaagc tg                        1422


