               SEQUENCE LISTING

<110> Scuola Internazionale Superiore di Studi Avanzati - SISSA

<120> FUNCTIONAL NUCLEIC ACID MOLECULES UPREGULATING THE TRANSLATION OF A FRATAXIN mRNA

<130> TSI-C-P2765PCT

<150> IT102019000011490
<151> 2019-07-11

<160> 98

<170> BiSSAP 1.3.6

<210> 1
<211> 167
<212> RNA
<213> Mus musculus


<220> 
<223> AS Uchl1 SINEB2

<400> 1
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggagu uauacgguaa     60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcucc                  167


<210> 2
<211> 77
<212> RNA
<213> Mus musculus


<220> 
<223> nt 44-120 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 2
gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga     60

guuccaaaca cuggucc                                                    77


<210> 3
<211> 29
<212> RNA
<213> Mus musculus


<220> 
<223> nt 64-92 of inverted SINE B2 transposable element derived from AS
      Uchl1

<400> 3
ccucguggug guugugaacc accaugugg                                      29


<210> 4
<211> 61
<212> RNA
<213> Mus musculus


<220> 
<223> nt 52-112 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 4
guuauacggu aaccucgugg ugguugugaa ccaccaugug gauggauauu gaguuccaaa     60

c                                                                     61


<210> 5
<211> 98
<212> RNA
<213> Mus musculus


<220> 
<223> nt 36-133 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 5
aucccccaga acuggaguua uacgguaacc ucgugguggu ugugaaccac cauguggaug     60

gauauugagu uccaaacacu gguccugugc aagagcau                             98


<210> 6
<211> 129
<212> RNA
<213> Mus musculus


<220> 
<223> nt 22-150 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 6
gaagagggca uuggaucccc cagaacugga guuauacggu aaccucgugg ugguugugaa     60

ccaccaugug gauggauauu gaguuccaaa cacugguccu gugcaagagc auccagugcu    120

cuuaagugc                                                            129


<210> 7
<211> 183
<212> RNA
<213> Mus musculus


<220> 
<223> nt 1-183 of inverted SINE B2 transposable element derived from AS
      Uchl1

<400> 7
gggcagugcu agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg     60

uaaccucgug gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc    120

ugugcaagag cauccagugc ucuuaagugc ugagccaucu cuuuagcucc agucucuuaa    180

gcu                                                                  183


<210> 8
<211> 67
<212> RNA
<213> Mus musculus


<220> 
<223> nt 44-110 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 8
gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga     60

guuccaa                                                               67


<210> 9
<211> 107
<212> RNA
<213> Mus musculus


<220> 
<223> nt 34-140 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 9
ggauccccca gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga     60

uggauauuga guuccaaaca cugguccugu gcaagagcau ccagugc                  107


<210> 10
<211> 127
<212> RNA
<213> Mus musculus


<220> 
<223> nt 24-150 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 10
agagggcauu ggauccccca gaacuggagu uauacgguaa ccucguggug guugugaacc     60

accaugugga uggauauuga guuccaaaca cugguccugu gcaagagcau ccagugcucu    120

uaagugc                                                              127


<210> 11
<211> 38
<212> RNA
<213> Mus musculus


<220> 
<223> nt 59-96 of inverted SINE B2 transposable element derived from AS
      Uchl1

<400> 11
gguaaccucg uggugguugu gaaccaccau guggaugg                             38


<210> 12
<211> 180
<212> RNA
<213> Artificial Sequence


<220> 
<223> G60A mutant of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 12
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggagu uauacgauaa     60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu    180


<210> 13
<211> 180
<212> RNA
<213> Artificial Sequence


<220> 
<223> G60C mutant of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 13
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggagu uauacgcuaa     60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu    180


<210> 14
<211> 180
<212> RNA
<213> Artificial Sequence


<220> 
<223> A51C mutant of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 14
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggcgu uauacgguaa     60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu    180


<210> 15
<211> 180
<212> RNA
<213> Artificial Sequence


<220> 
<223> C47G and G117C mutant of inverted SINE B2 transposable element
      derived from AS Uchl1

<400> 15
cagugcuaga ggaggucaga agagggcauu ggauccccca gaaguggagu uauacgguaa     60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugcuccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu    180


<210> 16
<211> 180
<212> RNA
<213> Artificial Sequence


<220> 
<223> 46-49/115-118 stem swap mutant of inverted SINE B2 transposable
      element derived from AS Uchl1

<400> 16
cagugcuaga ggaggucaga agagggcauu ggauccccca gauggugagu uauacgguaa     60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cgucaccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu    180


<210> 17
<211> 180
<212> RNA
<213> Artificial Sequence


<220> 
<223> 50-53 and 112-114 base swap mutant of inverted SINE B2
      transposable element derived from AS Uchl1

<400> 17
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacugcacu auacgguaac     60

cucguggugg uugugaacca ccauguggau ggauauugag uuccaaauga gugguccugu    120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu    180


<210> 18
<211> 116
<212> RNA
<213> Artificial Sequence


<220> 
<223> nt 27-142 of inverted SINE B2 transposable element derived from
      AS Uchl1

<400> 18
gggcauugga ucccccagaa cuggaguuau acgguaaccu cguggugguu gugaaccacc     60

auguggaugg auauugaguu ccaaacacug guccugugca agagcaucca gugcuc        116


<210> 19
<211> 77
<212> RNA
<213> Artificial Sequence


<220> 
<223> nt 44-120 A45G mutant of inverted SINE B2 transposable element
      derived from AS Uchl1

<400> 19
ggacuggagu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga     60

guuccaaaca cuggucc                                                    77


<210> 20
<211> 77
<212> RNA
<213> Artificial Sequence


<220> 
<223> nt 44-120 A51C mutant of inverted sine B2 transposable element
      derived from AS Uchl1

<400> 20
gaacuggcgu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga     60

guuccaaaca cuggucc                                                    77


<210> 21
<211> 107
<212> RNA
<213> Mus musculus


<220> 
<223> AS Txnip SINEB2

<400> 21
gaugccuuag aaguggaguu aagaguugug agcugccguu uuuugguucu gggacucgaa     60

cucguuuccu cugauacuau caaccaccaa gccaucucuu cagcccc                  107


<210> 22
<211> 131
<212> RNA
<213> Mus musculus


<220> 
<223> AS Uxt SINEB2 a

<400> 22
gccagaagaa guugugggau ucccuggaac uggagcaacc aacaguuugu gugcaccaug     60

uggguaaugg gaaucgaacc uggguccucu auaagacugg ccagugcucu uaacuacuga    120

ggugcauuuc u                                                         131


<210> 23
<211> 187
<212> RNA
<213> Mus musculus


<220> 
<223> AS Uxt SINEB2 b

<400> 23
uuauuuuaaa uauaugagua uuucaccugc auaggcgcac aguacccaca gagacuagaa     60

gaggguggca gaucuccuga gacuggaguu aaugcuugug agcugccaug uggaugcugg    120

aaaucaaacc cagguccuuu ggaaggcagg caggugcucu uaaucaugga agcaucucuu    180

cagcucc                                                              187


<210> 24
<211> 131
<212> RNA
<213> Mus musculus


<220> 
<223> AS Gadd45alpha SINEB2 a

<400> 24
cagcgacauc agaagaggau auuggauccc auuacagaug guugaaggcc accaugucgu     60

ugcugggaau gaacucaaga ccucuggaag agcagucagu gcucuuaacc ucugagccau    120

cucuccagcc c                                                         131


<210> 25
<211> 114
<212> RNA
<213> Mus musculus


<220> 
<223> AS Gadd45alpha SINEB2 b

<400> 25
auccccucca aagcucaaga ugguuguaag ccacccugug auugcuggga uuugaacuca     60

agaccuccgg aagagcaauu agugcucuua accgcugagc aaucucucca gccc          114


<210> 26
<211> 357
<212> RNA
<213> Mus musculus


<220> 
<223> AS Uchl1 SINEB2 + AS Uxt SINEB2 b

<400> 26
gugcagugcu agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg      60

uaaccucgug gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc     120

ugugcaagag cauccagugc ucuuaagugc ugagccaucu cuuuagcucc uuauuuuaaa     180

uauaugagua uuucaccugc auaggcgcac aguacccaca gagacuagaa gaggguggca     240

gaucuccuga gacuggaguu aaugcuugug agcugccaug uggaugcugg aaaucaaacc     300

cagguccuuu ggaaggcagg caggugcucu uaaucaugga agcaucucuu cagcucc        357


<210> 27
<211> 532
<212> RNA
<213> Mus musculus


<220> 
<223> 3x AS Uchl1 SINEB2

<400> 27
gugcagugcu agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg      60

uaaccucgug gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc     120

ugugcaagag cauccagugc ucuuaagugc ugagccaucu cuuuagcucc gugcgaauuc     180

ggugcagugc uagaggaggu cagaagaggg cauuggaucc cccagaacug gaguuauacg     240

guaaccucgu ggugguugug aaccaccaug uggauggaua uugaguucca aacacugguc     300

cugugcaaga gcauccagug cucuuaagug cugagccauc ucuuuagcuc cgugcgaauu     360

cggugcagug cuagaggagg ucagaagagg gcauuggauc ccccagaacu ggaguuauac     420

gguaaccucg uggugguugu gaaccaccau guggauggau auugaguucc aaacacuggu     480

ccugugcaag agcauccagu gcucuuaagu gcugagccau cucuuuagcu cc             532


<210> 28
<211> 228
<212> RNA
<213> Mus musculus


<220> 
<223> SINEB2/B3 consensus sequence from RepBase

<400> 28
uuuuuuuaaa aauuuauuuu uauuuuaugu guaugagugu uuugccugca uguaugucug     60

uguaccacgu gcgugccugg ugcccgcgga ggccagaaga gggcgucgga uccccuggaa    120

cuggaguuac agaugguugu gagccgccau gugggugcug ggaaucgaac ccggguccuc    180

uggaagagca gccagugcuc uuaaccgcug agccaucucu ccagcccc                 228


<210> 29
<211> 214
<212> RNA
<213> Mus musculus


<220> 
<223> AS Nars2 SINEB2/B3

<400> 29
uuuuuuuuac uuguauaggu guuuugccug cauguguauc uaucuaugua ccgaauaugu     60

uccugguauc cacagagacc aaaaguggau guuguaucuc cugaaauugg agucauagac    120

aguuaugagc ugccauuuga gugcuuggaa uagaacccag guccucuuaa agagcaucca    180

gugcucuuaa aaacugagac aucucuguag ccuc                                214


<210> 30
<211> 200
<212> RNA
<213> Mus musculus


<220> 
<223> AS Abhd11 SINEB2/B3

<400> 30
uuuauuuugc uuuauguguc ugaguguuug cuugaaugua ugucugugua ccacgccugu     60

accuugugcc uucagaguug agaggagggc auaggaucuc cuggaacugg aauugcaggu    120

gguugugagc cacccugugg guccugggga ccauacucca gcaagaacau caugugcucu    180

uaauuccuga gucuccaacc                                                200


<210> 31
<211> 214
<212> RNA
<213> Mus musculus


<220> 
<223> AS Ebp4.9 SINEB2/B3

<400> 31
uuuauuuacu uaucuuuaug uguaugagug uguugucaga cuguuauguc ugugugucac     60

augcaugccu gcuguucaug gaguccagaa gagggcaucg gauccccugg aacuggaguu    120

acagaugagu ggccauguga auguuaagaa ccaaaccugg guccucugaa agagcagaca    180

augcucuuaa cuacugagcu gucucuccag cccc                                214


<210> 32
<211> 205
<212> RNA
<213> Mus musculus


<220> 
<223> AS Wfdc5 SINEB2/B3

<400> 32
uuauuuuauu cguguaagug uuuugccagc aucuaugucu ucgcacuaug ugcaggucug     60

gugccugagg gguccagacg agagcacugg gucuccggga acuggaguua cagaucauug    120

ugagccacca ugugggugca gggaaucgaa ccugggaccu cuggaggagc agccacugcu    180

cuuaaccacu acacuauuuc uccag                                          205


<210> 33
<211> 121
<212> RNA
<213> Mus musculus


<220> 
<223> AS Pgbd1 SINEB2/B3

<400> 33
ucuguggacc acuguguaca gaagccugag aaggcuagca gauccccaga acuggaacug     60

ugagacgcug ugcuauggag gugcuaggaa cugaaaaugg auggguccuc ugcaagagca    120

g                                                                    121


<210> 34
<211> 191
<212> RNA
<213> Mus musculus


<220> 
<223> AS Gsk3b SINEB2/B3

<400> 34
uuguuuuaau ugaauggcua uaggguguuu cuucuguaug uauaucuaug uuugguaccu     60

acagaggcau cagauccucu ggaacuguag uugcugacag uugugagcug ucauggggau    120

gcuggaauug aaccuggauc cuaugaaaga acagccagug uucuuaaccg cugagcuauc    180

ucuccaggcc c                                                         191


<210> 35
<211> 205
<212> RNA
<213> Mus musculus


<220> 
<223> AS Rhod SINEB2_Mm2

<400> 35
uuuuuuuuuu aauuuuaaaa aaaaagauuu uauuuauuua uuuuauauau gaugaguaca     60

cugucacucu uuucagacac ccuagaaaag gggggcauca gaucccauua cagaugguug    120

ugagccacau gguugcuggg aauugaccuc aggaccucug aaagagcagu cagugcucuc    180

aaccuuugag ucaucucucc agccc                                          205


<210> 36
<211> 190
<212> RNA
<213> Mus musculus


<220> 
<223> AS Rhod SINEB2/B3A

<400> 36
auguauaucu guaaugggac auacucacau acaugggcac gugaguauaa aaggccagaa     60

gagagcacug gacccucugg aguugagauu cuaagcaguu gugaaccauc ugauguaggu    120

gcugggaacu gaacuugggu ccuuugcuag agaaguaugu cucuuaacca cugagccgua    180

ucuccauccc                                                           190


<210> 37
<211> 169
<212> RNA
<213> Mus musculus


<220> 
<223> AS E4f1 SINEB2_Mm2

<400> 37
uaaagauuua uucauuaagu acacuguagc uaucuucaga cgcaucagaa gagggcguca     60

gaucucuuua caggugguug ugagccacca ugugguugcu ggaauuugaa cucaggaccu    120

ucaaaagagc agucaguguu cuuaaccgcu gagccaucuc uccaacccc                169


<210> 38
<211> 159
<212> RNA
<213> Mus musculus


<220> 
<223> AS E4f1 SINEB2_Mm1t

<400> 38
uuauuuauua uaaguacacu guagcugucu ucagacacaa caaaagaggg cgucagaucu     60

cauuacaggu gguugagcca ccaugugguu gcugggauuu gaacucagga ccuucagaac    120

agucagugcu cuuacccacu gagccagcga gccagcccc                           159


<210> 39
<211> 77
<212> RNA
<213> Artificial Sequence


<220> 
<223> 44-120 U78G SINEUP

<400> 39
gaacuggagu uauacgguaa ccucguggug guugggaacc accaugugga uggauauuga     60

guuccaaaca cuggucc                                                    77


<210> 40
<211> 77
<212> RNA
<213> Artificial Sequence


<220> 
<223> 44-120 GUG77-79CCC SINEUP

<400> 40
gaacuggagu uauacgguaa ccucguggug guucccaacc accaugugga uggauauuga     60

guuccaaaca cuggucc                                                    77


<210> 41
<211> 77
<212> RNA
<213> Artificial Sequence


<220> 
<223> 44-120 SINEUP strong

<400> 41
ggaccggagu uauacgguaa ccgcguggug guugugaacc accacgcgga uggauauuga     60

guuccaaaca ccggucc                                                    77


<210> 42
<211> 77
<212> RNA
<213> Artificial Sequence


<220> 
<223> 44-120 SINEUP weak

<400> 42
gaacuagagu uauacgguaa ccacauggug guugugaacc accaugugga uggauauuga     60

guuccaaaca cuaguuc                                                    77


<210> 43
<211> 206
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP 071 and miniSINEUP 071 effector domain

<400> 43
uuauuuuaaa uauaugagua uuucaccugc auaggcgcac aguacccaca gagacuagaa     60

gaggguagua gauccccuag aacuggaguu auacgguaac cucguggugg uugugagcua    120

ccauguggau ggauacuggg aaucaaaccc agguccugug gaaggcaggc aggugcucuc    180

aagcacugag ccaucucuuc agcucc                                         206


<210> 44
<211> 206
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP 072 and miniSINEUP 072 effector domain

<400> 44
uuauuuuaaa uauaugagua uuucaccugc auaggcgcac agugcucaag gagaucagaa     60

gagggcauca gaucuccuga gacuggaguu auacgguaac cucgugaugg uugugaacua    120

ccauguggau ggauauugag uuccaaacac agguccugug caagagcagc aggugcucuu    180

aagcacggaa ccaucucuuu agcucc                                         206


<210> 45
<211> 156
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP 073 and miniSINEUP 073 effector domain

<400> 45
gaggcuagaa gaggguauca gauccccuga gacuggaguu auacgguaac cucguggugg     60

uugugagcca ccauguggau ggauacugag aaccaaaccc ugguccugug caagagcauc    120

aggugcucuu aagcacggaa ccaucucuuc agcucc                              156


<210> 46
<211> 68
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP 074 and miniSINEUP 074 effector domain

<400> 46
guccugugca agagcaucga acucggugcu cuuaagcaca gaagccacca agccaucucu     60

ucagcccc                                                              68


<210> 47
<211> 110
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP 075 and miniSINEUP 075 effector domain

<400> 47
cagugcuaga ggaggucaga agagggcauc ccccagccuc guggugguug ugaaccacca     60

uguggcugug caagagcaug cucuuaagug cugagccauc ucuuuagcuc               110


<210> 48
<211> 126
<212> RNA
<213> Artificial Sequence


<220> 
<223> 24-150 effector domain

<400> 48
gagggcauug gaucccccag aacuggaguu auacgguaac cucguggugg uugugaacca     60

ccauguggau ggauauugag uuccaaacac ugguccugug caagagcauc cagugcucuu    120

aagugc                                                               126


<210> 49
<211> 89
<212> RNA
<213> Artificial Sequence


<220> 
<223> C_34-122 effector domain

<400> 49
ggauccccca gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga     60

uggauauuga guuccaaaca cugguccug                                       89


<210> 50
<211> 72
<212> RNA
<213> Artificial Sequence


<220> 
<223> TM effector domain

<400> 50
ugcuagagga ggucagaaga gggcauugga ugcaaaucca gugcucuuaa gugcugagcc     60

aucucuuuag cu                                                         72


<210> 51
<211> 94
<212> RNA
<213> Artificial Sequence


<220> 
<223> MC2 effector domain

<400> 51
gagggcauug gaucccccag aacuggaguu auacgguaac gauggauauu gaguuccaaa     60

cacugguccu gugcaagagc auccagugcu cuua                                 94


<210> 52
<211> 13
<212> RNA
<213> Artificial Sequence


<220> 
<223> linker

<400> 52
aucugcagaa uuc                                                       13


<210> 53
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV(d) IRES

<400> 53
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguuggguc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 54
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV(i) IRES

<400> 54
guuacguuug guuuuucuuu gagguuuagg auucgugcuc auggugcacg gucuacgaga      60

ccucccgggg cacucgcaag cacccuauca ggcaguacca caaggccuuu cgcgacccaa     120

cacuacucgg cuagcagucu ugcgggggca cgcccaaauc uccaggcauu gagcggguuu     180

auccaagaaa ggacccgguc guccuggcaa uuccggugua cucaccgguu ccgcagacca     240

cuauggcucu cccgggaggg gggguccugg aggcugcacg acacucauac uaacgccaug     300

gcuagacgcu uucugcguga agacaguagu uccucacagg ggagugauuc augguggagu     360

gucgccccca ucagggggcu ggc                                             383


<210> 55
<211> 312
<212> RNA
<213> Human poliovirus


<220> 
<223> Polio(d) IRES

<400> 55
augagucugg acaucccuca ccggugacgg ugguccaggc ugcguuggcg gccuaccuau     60

ggcuaacgcc augggacgcu aguugugaac aaggugugaa gagccuauug agcuacauaa    120

gaauccuccg gccccugaau gcggcuaauc ccaaccucgg agcagguggu cacaaaccag    180

ugauuggccu gucguaacgc gcaaguccgu ggcggaaccg acuacuuugg guguccgugu    240

uuccuuuuau uuuauugugg cugcuuaugg ugacaaucac agauuguuau cauaaagcga    300

auuggauugg cc                                                        312


<210> 56
<211> 312
<212> RNA
<213> Human poliovirus


<220> 
<223> Polio(i) IRES

<400> 56
ggccaaucca auucgcuuua ugauaacaau cugugauugu caccauaagc agccacaaua     60

aaauaaaagg aaacacggac acccaaagua gucgguuccg ccacggacuu gcgcguuacg    120

acaggccaau cacugguuug ugaccaccug cuccgagguu gggauuagcc gcauucaggg    180

gccggaggau ucuuauguag cucaauaggc ucuucacacc uuguucacaa cuagcguccc    240

auggcguuag ccauagguag gccgccaacg cagccuggac caccgucacc ggugagggau    300

guccagacuc au                                                        312


<210> 57
<211> 576
<212> RNA
<213> Encephalomyocarditis virus


<220> 
<223> EMCV(d) IRES

<400> 57
cccccccucu cccucccccc ccccuaacgu uacuggccga agccgcuugg aauaaggccg      60

gugugcguuu gucuauaugu uauuuuccac cauauugccg ucuuuuggca augugagggc     120

ccggaaaccu ggcccugucu ucuugacgag cauuccuagg ggucuuuccc cucucgccaa     180

aggaaugcaa ggucuguuga augucgugaa ggaagcaguu ccucuggaag cuucuugaag     240

acaaacaacg ucuguagcga cccuuugcag gcagcggaac cccccaccug gcgacaggug     300

ccucugcggc caaaagccac guguauaaga uacaccugca aaggcggcac aaccccagug     360

ccacguugug aguuggauag uuguggaaag agucaaaugg cucuccucaa gcguauucaa     420

caaggggcug aaggaugccc agaagguacc ccauuguaug ggaucugauc uggggccucg     480

gugcacaugc uuuacaugug uuuagucgag guuaaaaaac gucuaggccc cccgaaccac     540

ggggacgugg uuuuccuuug aaaaacacga ugauaa                               576


<210> 58
<211> 576
<212> RNA
<213> Encephalomyocarditis virus


<220> 
<223> ECMV(i) IRES

<400> 58
uuaucaucgu guuuuucaaa ggaaaaccac guccccgugg uucggggggc cuagacguuu      60

uuuaaccucg acuaaacaca uguaaagcau gugcaccgag gccccagauc agaucccaua     120

caauggggua ccuucugggc auccuucagc cccuuguuga auacgcuuga ggagagccau     180

uugacucuuu ccacaacuau ccaacucaca acguggcacu gggguugugc cgccuuugca     240

gguguaucuu auacacgugg cuuuuggccg cagaggcacc ugucgccagg ugggggguuc     300

cgcugccugc aaagggucgc uacagacguu guuugucuuc aagaagcuuc cagaggaacu     360

gcuuccuuca cgacauucaa cagaccuugc auuccuuugg cgagagggga aagaccccua     420

ggaaugcucg ucaagaagac agggccaggu uuccgggccc ucacauugcc aaaagacggc     480

aauauggugg aaaauaacau auagacaaac gcacaccggc cuuauuccaa gcggcuucgg     540

ccaguaacgu uagggggggg ggagggagag gggggg                               576


<210> 59
<211> 192
<212> RNA
<213> Cricket paralysis virus


<220> 
<223> CrPV(d) IRES

<400> 59
aaagcaaaaa ugugaucuug cuuguaaaua caauuuugag agguuaauaa auuacaagua     60

gugcuauuuu uguauuuagg uuagcuauuu agcuuuacgu uccaggaugc cuaguggcag    120

ccccacaaua uccaggaagc ccucucugcg guuuuucaga uuagguaguc gaaaaaccua    180

agaaauuuac cu                                                        192


<210> 60
<211> 192
<212> RNA
<213> Cricket paralysis virus


<220> 
<223> CrPV(i) IRES

<400> 60
agguaaauuu cuuagguuuu ucgacuaccu aaucugaaaa accgcagaga gggcuuccug     60

gauauugugg ggcugccacu aggcauccug gaacguaaag cuaaauagcu aaccuaaaua    120

caaaaauagc acuacuugua auuuauuaac cucucaaaau uguauuuaca agcaagauca    180

cauuuuugcu uu                                                        192


<210> 61
<211> 231
<212> RNA
<213> Homo sapiens


<220> 
<223> Apaf-1(d) IRES

<400> 61
cagagaucca ggggaggcgc cugugaggcc cggaccugcc ccggggcgaa ggguaugugg     60

cgagacagag cccugcaccc cuaauucccg guggaaaacu ccuguugccg uuucccucca    120

ccggccugga gucucccagu cuugucccgg cagugccgcc cuccccacua agaccuaggc    180

gcaaaggcuu ggcucauggu ugacagcuca gagagagaaa gaucugaggg a             231


<210> 62
<211> 231
<212> RNA
<213> Homo sapiens


<220> 
<223> Apaf-1(i) IRES

<400> 62
ucccucagau cuuucucucu cugagcuguc aaccaugagc caagccuuug cgccuagguc     60

uuagugggga gggcggcacu gccgggacaa gacugggaga cuccaggccg guggagggaa    120

acggcaacag gaguuuucca ccgggaauua ggggugcagg gcucugucuc gccacauacc    180

cuucgccccg gggcaggucc gggccucaca ggcgccuccc cuggaucucu g             231


<210> 63
<211> 460
<212> RNA
<213> Homo sapiens


<220> 
<223> ELG-1(d) IRES

<400> 63
acuuuuggug ggcauuuaaa aaugugugug uauguguaua uauguaugug uauguaugug      60

uauauaugua uauguaugua uguaucgcgu guaugugugu auguaugcau guguauguau     120

guauaugcau guauguguau guguauauau guaugugugu guauguauau guguguguau     180

guguaugugu guguguaugu guguguguau guauguaugu auguauaugu auuauacaca     240

uauacacaua uugguuuuuu uaaucauuug agaguuaguu gaagauaaaa acccaucacc     300

ccuaaaugua uuccaaagaa uaagaacauu guuuuauaca uagcacacuu aacaaaauca     360

agaaauuuaa cauuaauaca guacuguuac cuaauccgua gucgauuuuc aaauuuuguc     420

aguuguucca auaauguccu uuauauauuc cccgcccagc                           460


<210> 64
<211> 460
<212> RNA
<213> Homo sapiens


<220> 
<223> ELG-1(i) IRES

<400> 64
gcugggcggg gaauauauaa aggacauuau uggaacaacu gacaaaauuu gaaaaucgac      60

uacggauuag guaacaguac uguauuaaug uuaaauuucu ugauuuuguu aagugugcua     120

uguauaaaac aauguucuua uucuuuggaa uacauuuagg ggugaugggu uuuuaucuuc     180

aacuaacucu caaaugauua aaaaaaccaa uauguguaua uguguauaau acauauacau     240

acauacauac auacacacac acauacacac acacauacac auacacacac auauacauac     300

acacacauac auauauacac auacacauac augcauauac auacauacac augcauacau     360

acacacauac acgcgauaca uacauacaua uacauauaua cacauacaua cacauacaua     420

uauacacaua cacacacauu uuuaaaugcc caccaaaagu                           460


<210> 65
<211> 395
<212> RNA
<213> Homo sapiens


<220> 
<223> cMYC full length(d) IRES

<400> 65
aauuccagcg agaggcagag ggagcgagcg ggcggccggc uaggguggaa gagccgggcg      60

agcagagcug cgcugcgggc guccugggaa gggagauccg gagcgaauag ggggcuucgc     120

cucuggccca gcccucccgc uugauccccc aggccagcgg uccgcaaccc uugccgcauc     180

cacgaaacuu ugcccauagc agcgggcggg cacuuugcac uggaacuuac aacacccgag     240

caaggacgcg acucucccga cgcggggagg cuauucugcc cauuugggga cacuuccccg     300

ccgcugccag gacccgcuuc ucugaaaggc ucuccuugca gcugcuuaga cgcuggauuu     360

uuuucgggua guggaaaacc agcagccucc cgcga                                395


<210> 66
<211> 395
<212> RNA
<213> Homo sapiens


<220> 
<223> cMYC full length(i) IRES

<400> 66
ucgcgggagg cugcugguuu uccacuaccc gaaaaaaauc cagcgucuaa gcagcugcaa      60

ggagagccuu ucagagaagc ggguccuggc agcggcgggg aagugucccc aaaugggcag     120

aauagccucc ccgcgucggg agagucgcgu ccuugcucgg guguuguaag uuccagugca     180

aagugcccgc ccgcugcuau gggcaaaguu ucguggaugc ggcaaggguu gcggaccgcu     240

ggccuggggg aucaagcggg agggcugggc cagaggcgaa gcccccuauu cgcuccggau     300

cucccuuccc aggacgcccg cagcgcagcu cugcucgccc ggcucuucca cccuagccgg     360

ccgcccgcuc gcucccucug ccucucgcug gaauu                                395


<210> 67
<211> 48
<212> RNA
<213> Homo sapiens


<220> 
<223> cMYC short variant(d) IRES

<400> 67
gggcacuuug cacuggaacu uacaacaccc gagcaaggac gcgacucu                  48


<210> 68
<211> 48
<212> RNA
<213> Homo sapiens


<220> 
<223> cMYC short variant(i) IRES

<400> 68
agagucgcgu ccuugcucgg guguuguaag uuccagugca aagugccc                  48


<210> 69
<211> 71
<212> RNA
<213> Homo sapiens


<220> 
<223> DMD(d) IRES

<400> 69
guacugacau cguagaugga aaucauaaac ugacucuugg uuugauuugg aauauaaucc     60

uccacuggca g                                                          71


<210> 70
<211> 71
<212> RNA
<213> Homo sapiens


<220> 
<223> DMD(i) IRES

<400> 70
cugccagugg aggauuauau uccaaaucaa accaagaguc aguuuaugau uuccaucuac     60

gaugucagua c                                                          71


<210> 71
<211> 303
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV delta II(d) IRES

<400> 71
gccagccccc ugaugggggc gacacuccac caugaaucac ccccccuccc gggagagcca     60

uaguggucug cggaaccggu gaguacaccg gaauugccag gacgaccggg uccuuucuug    120

gauaaacccg cucaaugccu ggagauuugg gcgugccccc gcaagacugc uagccgagua    180

guguuggguc gcgaaaggcc uugugguacu gccugauagg gugcuugcga gugccccggg    240

aggucucgua gaccgugcac caugagcacg aauccuaaac cucaaagaaa aaccaaacgu    300

aac                                                                  303


<210> 72
<211> 367
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV delta IIIa(d) IRES

<400> 72
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaaauug ccaggacgac cggguccuuu     180

cuuggauaaa cccgcucaau gccuggagau uugggcgugc ccccgcaaga cugcuagccg     240

aguaguguug ggucgcgaaa ggccuugugg uacugccuga uagggugcuu gcgagugccc     300

cgggaggucu cguagaccgu gcaccaugag cacgaauccu aaaccucaaa gaaaaaccaa     360

acguaac                                                               367


<210> 73
<211> 356
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV delta IIId(d) IRES

<400> 73
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uacuuguggu acugccugau agggugcuug cgagugcccc gggaggucuc     300

guagaccgug caccaugagc acgaauccua aaccucaaag aaaaaccaaa cguaac         356


<210> 74
<211> 330
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV delta IV(d) IRES

<400> 74
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguuggguc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua                                      330


<210> 75
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV G266->C(d) IRES

<400> 75
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguucgguc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 76
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV U228->C(d) IRES

<400> 76
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauucgg gcgugccccc     240

gcaagacugc uagccgagua guguuggguc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 77
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV G267->C(d) IRES

<400> 77
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguugcguc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 78
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV G268->C(d) IRES

<400> 78
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguuggcuc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 79
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV G266G267G268->C266C267C268(d) IRES

<400> 79
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguucccuc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 80
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV G266->A/G268->T(d) IRES

<400> 80
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguuaguuc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 81
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HVC IIIa->IIIa-comp; AGTA->TCAT(d) IRES

<400> 81
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gucaucaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguuggguc gcgaaaggcc uugugguacu gccugauagg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 82
<211> 383
<212> RNA
<213> Hepatitis C virus


<220> 
<223> HCV IIIe-IIIe-comp; TGATAG->ACTATC(d) IRES

<400> 82
gccagccccc ugaugggggc gacacuccac caugaaucac uccccuguga ggaacuacug      60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac     120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag     180

gacgaccggg uccuuucuug gauaaacccg cucaaugccu ggagauuugg gcgugccccc     240

gcaagacugc uagccgagua guguuggguc gcgaaaggcc uugugguacu gccacuaucg     300

gugcuugcga gugccccggg aggucucgua gaccgugcac caugagcacg aauccuaaac     360

cucaaagaaa aaccaaacgu aac                                             383


<210> 83
<211> 1190
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -40/+32 relative to M1-AUG

<400> 83
ccggcuacug cgcggcgccc gagaguccac augcugcucc gggucugccg cccgcuccgc      60

ccuccagcgc ugaucugcag aauuccagug cuagaggagg ucagaagagg gcauuggauc     120

ccccagaacu ggaguuauac gguaaccucg uggugguugu gaaccaccau guggauggau     180

auugaguucc aaacacuggu ccugugcaag agcauccagu gcucuuaagu gcugagccau     240

cucuuuagcu ccagucucuu aaaaaacaaa caaacgaacg aacagcaagg gagcugggua     300

ugacaacaca uacuauaauu cuaguacuca ggaugcugaa acaggaggau ugccugacug     360

ggagauauaa ggagaaucug uugucacccc caccccuccc cauaaaggca gaauaaaaga     420

acguccuaua aacaaauaaa caaacaaccc aauaaaacaa aaccaagauc ucuccaccuu     480

uucuuugcuu uuucagacuu uguaauaagg cccuuuggag ugcaggauau ucggcaggac     540

aagcagagag ggagaccauc aguucuuucu uugaucaaga agacuauguu ccuuagcaaa     600

cuggugugua uuaucucuua ugcaaugagc cuggaaagag ggcacagcca ccgaggaugg     660

uacagcaugg auggauggua cgcuacagag acucgggagc ccaacuguga guggcugacu     720

ggcaugguag guucagggaa gaauuggccu gugaagaaaa uguucuugaa aagugaacaa     780

ggugcaggag guaggagugg guccugggca aagcaggggg ugcaucccag ccucagggaa     840

uagcacagca gaggucuguu gaugcaugcg agugcaugac cugcuugcca auagacgauc     900

aagaaugggc aaagcaucau gggugaugag ugggagaggg gaugagacau uccuuucucc     960

cugcugagac uuccauugaa ccgaugaguu cugaauagaa gaugcccccc caccccccca    1020

ccaguguaga aucugaaggg aggcauauau uacccuauau uacucugugu uggcggcgag    1080

cuaucugaca gccaaccuuc ccauacauuu cauugggcau acacuaauga caggaaguuc    1140

cuuuugcuug uaugcaagag auggcucaca cgauggagaa uuuaaucuug               1190


<210> 84
<211> 1162
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -40/+4 relative to M1-AUG

<400> 84
acaugcugcu ccgggucugc cgcccgcucc gcccuccagc gcugaucugc agaauuccag      60

ugcuagagga ggucagaaga gggcauugga ucccccagaa cuggaguuau acgguaaccu     120

cguggugguu gugaaccacc auguggaugg auauugaguu ccaaacacug guccugugca     180

agagcaucca gugcucuuaa gugcugagcc aucucuuuag cuccagucuc uuaaaaaaca     240

aacaaacgaa cgaacagcaa gggagcuggg uaugacaaca cauacuauaa uucuaguacu     300

caggaugcug aaacaggagg auugccugac ugggagauau aaggagaauc uguugucacc     360

cccaccccuc cccauaaagg cagaauaaaa gaacguccua uaaacaaaua aacaaacaac     420

ccaauaaaac aaaaccaaga ucucuccacc uuuucuuugc uuuuucagac uuuguaauaa     480

ggcccuuugg agugcaggau auucggcagg acaagcagag agggagacca ucaguucuuu     540

cuuugaucaa gaagacuaug uuccuuagca aacuggugug uauuaucucu uaugcaauga     600

gccuggaaag agggcacagc caccgaggau gguacagcau ggauggaugg uacgcuacag     660

agacucggga gcccaacugu gaguggcuga cuggcauggu agguucaggg aagaauuggc     720

cugugaagaa aauguucuug aaaagugaac aaggugcagg agguaggagu ggguccuggg     780

caaagcaggg ggugcauccc agccucaggg aauagcacag cagaggucug uugaugcaug     840

cgagugcaug accugcuugc caauagacga ucaagaaugg gcaaagcauc augggugaug     900

agugggagag gggaugagac auuccuuucu cccugcugag acuuccauug aaccgaugag     960

uucugaauag aagaugcccc cccacccccc caccagugua gaaucugaag ggaggcauau    1020

auuacccuau auuacucugu guuggcggcg agcuaucuga cagccaaccu ucccauacau    1080

uucauugggc auacacuaau gacaggaagu uccuuuugcu uguaugcaag agauggcuca    1140

cacgauggag aauuuaaucu ug                                             1162


<210> 85
<211> 1171
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -21/+32 relative to M1-AUG

<400> 85
ccggcuacug cgcggcgccc gagaguccac augcugcucc gggucugccg cccaucugca      60

gaauuccagu gcuagaggag gucagaagag ggcauuggau cccccagaac uggaguuaua     120

cgguaaccuc guggugguug ugaaccacca uguggaugga uauugaguuc caaacacugg     180

uccugugcaa gagcauccag ugcucuuaag ugcugagcca ucucuuuagc uccagucucu     240

uaaaaaacaa acaaacgaac gaacagcaag ggagcugggu augacaacac auacuauaau     300

ucuaguacuc aggaugcuga aacaggagga uugccugacu gggagauaua aggagaaucu     360

guugucaccc ccaccccucc ccauaaaggc agaauaaaag aacguccuau aaacaaauaa     420

acaaacaacc caauaaaaca aaaccaagau cucuccaccu uuucuuugcu uuuucagacu     480

uuguaauaag gcccuuugga gugcaggaua uucggcagga caagcagaga gggagaccau     540

caguucuuuc uuugaucaag aagacuaugu uccuuagcaa acuggugugu auuaucucuu     600

augcaaugag ccuggaaaga gggcacagcc accgaggaug guacagcaug gauggauggu     660

acgcuacaga gacucgggag cccaacugug aguggcugac uggcauggua gguucaggga     720

agaauuggcc ugugaagaaa auguucuuga aaagugaaca aggugcagga gguaggagug     780

gguccugggc aaagcagggg gugcauccca gccucaggga auagcacagc agaggucugu     840

ugaugcaugc gagugcauga ccugcuugcc aauagacgau caagaauggg caaagcauca     900

ugggugauga gugggagagg ggaugagaca uuccuuucuc ccugcugaga cuuccauuga     960

accgaugagu ucugaauaga agaugccccc ccaccccccc accaguguag aaucugaagg    1020

gaggcauaua uuacccuaua uuacucugug uuggcggcga gcuaucugac agccaaccuu    1080

cccauacauu ucauugggca uacacuaaug acaggaaguu ccuuuugcuu guaugcaaga    1140

gauggcucac acgauggaga auuuaaucuu g                                   1171


<210> 86
<211> 1143
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -21/+4 relative to M1-AUG

<400> 86
acaugcugcu ccgggucugc cgcccaucug cagaauucca gugcuagagg aggucagaag      60

agggcauugg aucccccaga acuggaguua uacgguaacc ucgugguggu ugugaaccac     120

cauguggaug gauauugagu uccaaacacu gguccugugc aagagcaucc agugcucuua     180

agugcugagc caucucuuua gcuccagucu cuuaaaaaac aaacaaacga acgaacagca     240

agggagcugg guaugacaac acauacuaua auucuaguac ucaggaugcu gaaacaggag     300

gauugccuga cugggagaua uaaggagaau cuguugucac ccccaccccu ccccauaaag     360

gcagaauaaa agaacguccu auaaacaaau aaacaaacaa cccaauaaaa caaaaccaag     420

aucucuccac cuuuucuuug cuuuuucaga cuuuguaaua aggcccuuug gagugcagga     480

uauucggcag gacaagcaga gagggagacc aucaguucuu ucuuugauca agaagacuau     540

guuccuuagc aaacuggugu guauuaucuc uuaugcaaug agccuggaaa gagggcacag     600

ccaccgagga ugguacagca uggauggaug guacgcuaca gagacucggg agcccaacug     660

ugaguggcug acuggcaugg uagguucagg gaagaauugg ccugugaaga aaauguucuu     720

gaaaagugaa caaggugcag gagguaggag uggguccugg gcaaagcagg gggugcaucc     780

cagccucagg gaauagcaca gcagaggucu guugaugcau gcgagugcau gaccugcuug     840

ccaauagacg aucaagaaug ggcaaagcau caugggugau gagugggaga ggggaugaga     900

cauuccuuuc ucccugcuga gacuuccauu gaaccgauga guucugaaua gaagaugccc     960

ccccaccccc ccaccagugu agaaucugaa gggaggcaua uauuacccua uauuacucug    1020

uguuggcggc gagcuaucug acagccaacc uucccauaca uuucauuggg cauacacuaa    1080

ugacaggaag uuccuuuugc uuguaugcaa gagauggcuc acacgaugga gaauuuaauc    1140

uug                                                                  1143


<210> 87
<211> 1158
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -40/+0 relative to M1-AUG

<400> 87
gcugcuccgg gucugccgcc cgcuccgccc uccagcgcug aucugcagaa uuccagugcu      60

agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg uaaccucgug     120

gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc ugugcaagag     180

cauccagugc ucuuaagugc ugagccaucu cuuuagcucc agucucuuaa aaaacaaaca     240

aacgaacgaa cagcaaggga gcuggguaug acaacacaua cuauaauucu aguacucagg     300

augcugaaac aggaggauug ccugacuggg agauauaagg agaaucuguu gucaccccca     360

ccccucccca uaaaggcaga auaaaagaac guccuauaaa caaauaaaca aacaacccaa     420

uaaaacaaaa ccaagaucuc uccaccuuuu cuuugcuuuu ucagacuuug uaauaaggcc     480

cuuuggagug caggauauuc ggcaggacaa gcagagaggg agaccaucag uucuuucuuu     540

gaucaagaag acuauguucc uuagcaaacu gguguguauu aucucuuaug caaugagccu     600

ggaaagaggg cacagccacc gaggauggua cagcauggau ggaugguacg cuacagagac     660

ucgggagccc aacugugagu ggcugacugg caugguaggu ucagggaaga auuggccugu     720

gaagaaaaug uucuugaaaa gugaacaagg ugcaggaggu aggagugggu ccugggcaaa     780

gcagggggug caucccagcc ucagggaaua gcacagcaga ggucuguuga ugcaugcgag     840

ugcaugaccu gcuugccaau agacgaucaa gaaugggcaa agcaucaugg gugaugagug     900

ggagagggga ugagacauuc cuuucucccu gcugagacuu ccauugaacc gaugaguucu     960

gaauagaaga ugccccccca cccccccacc aguguagaau cugaagggag gcauauauua    1020

cccuauauua cucuguguug gcggcgagcu aucugacagc caaccuuccc auacauuuca    1080

uugggcauac acuaaugaca ggaaguuccu uuugcuugua ugcaagagau ggcucacacg    1140

auggagaauu uaaucuug                                                  1158


<210> 88
<211> 1132
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -14/+0 relative to M1-AUG

<400> 88
gcugcuccgg gucuaucugc agaauuccag ugcuagagga ggucagaaga gggcauugga      60

ucccccagaa cuggaguuau acgguaaccu cguggugguu gugaaccacc auguggaugg     120

auauugaguu ccaaacacug guccugugca agagcaucca gugcucuuaa gugcugagcc     180

aucucuuuag cuccagucuc uuaaaaaaca aacaaacgaa cgaacagcaa gggagcuggg     240

uaugacaaca cauacuauaa uucuaguacu caggaugcug aaacaggagg auugccugac     300

ugggagauau aaggagaauc uguugucacc cccaccccuc cccauaaagg cagaauaaaa     360

gaacguccua uaaacaaaua aacaaacaac ccaauaaaac aaaaccaaga ucucuccacc     420

uuuucuuugc uuuuucagac uuuguaauaa ggcccuuugg agugcaggau auucggcagg     480

acaagcagag agggagacca ucaguucuuu cuuugaucaa gaagacuaug uuccuuagca     540

aacuggugug uauuaucucu uaugcaauga gccuggaaag agggcacagc caccgaggau     600

gguacagcau ggauggaugg uacgcuacag agacucggga gcccaacugu gaguggcuga     660

cuggcauggu agguucaggg aagaauuggc cugugaagaa aauguucuug aaaagugaac     720

aaggugcagg agguaggagu ggguccuggg caaagcaggg ggugcauccc agccucaggg     780

aauagcacag cagaggucug uugaugcaug cgagugcaug accugcuugc caauagacga     840

ucaagaaugg gcaaagcauc augggugaug agugggagag gggaugagac auuccuuucu     900

cccugcugag acuuccauug aaccgaugag uucugaauag aagaugcccc cccacccccc     960

caccagugua gaaucugaag ggaggcauau auuacccuau auuacucugu guuggcggcg    1020

agcuaucuga cagccaaccu ucccauacau uucauugggc auacacuaau gacaggaagu    1080

uccuuuugcu uguaugcaag agauggcuca cacgauggag aauuuaaucu ug            1132


<210> 89
<211> 1136
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -14/+4 relative to M1-AUG

<400> 89
acaugcugcu ccgggucuau cugcagaauu ccagugcuag aggaggucag aagagggcau      60

uggauccccc agaacuggag uuauacggua accucguggu gguugugaac caccaugugg     120

auggauauug aguuccaaac acugguccug ugcaagagca uccagugcuc uuaagugcug     180

agccaucucu uuagcuccag ucucuuaaaa aacaaacaaa cgaacgaaca gcaagggagc     240

uggguaugac aacacauacu auaauucuag uacucaggau gcugaaacag gaggauugcc     300

ugacugggag auauaaggag aaucuguugu cacccccacc ccuccccaua aaggcagaau     360

aaaagaacgu ccuauaaaca aauaaacaaa caacccaaua aaacaaaacc aagaucucuc     420

caccuuuucu uugcuuuuuc agacuuugua auaaggcccu uuggagugca ggauauucgg     480

caggacaagc agagagggag accaucaguu cuuucuuuga ucaagaagac uauguuccuu     540

agcaaacugg uguguauuau cucuuaugca augagccugg aaagagggca cagccaccga     600

ggaugguaca gcauggaugg augguacgcu acagagacuc gggagcccaa cugugagugg     660

cugacuggca ugguagguuc agggaagaau uggccuguga agaaaauguu cuugaaaagu     720

gaacaaggug caggagguag gagugggucc ugggcaaagc agggggugca ucccagccuc     780

agggaauagc acagcagagg ucuguugaug caugcgagug caugaccugc uugccaauag     840

acgaucaaga augggcaaag caucaugggu gaugaguggg agaggggaug agacauuccu     900

uucucccugc ugagacuucc auugaaccga ugaguucuga auagaagaug cccccccacc     960

cccccaccag uguagaaucu gaagggaggc auauauuacc cuauauuacu cuguguuggc    1020

ggcgagcuau cugacagcca accuucccau acauuucauu gggcauacac uaaugacagg    1080

aaguuccuuu ugcuuguaug caagagaugg cucacacgau ggagaauuua aucuug        1136


<210> 90
<211> 1162
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -40/+4 relative to M76-AUG

<400> 90
ucaucaaaua gacacucugc uuuuugacau uccaaaucug guugaucugc agaauuccag      60

ugcuagagga ggucagaaga gggcauugga ucccccagaa cuggaguuau acgguaaccu     120

cguggugguu gugaaccacc auguggaugg auauugaguu ccaaacacug guccugugca     180

agagcaucca gugcucuuaa gugcugagcc aucucuuuag cuccagucuc uuaaaaaaca     240

aacaaacgaa cgaacagcaa gggagcuggg uaugacaaca cauacuauaa uucuaguacu     300

caggaugcug aaacaggagg auugccugac ugggagauau aaggagaauc uguugucacc     360

cccaccccuc cccauaaagg cagaauaaaa gaacguccua uaaacaaaua aacaaacaac     420

ccaauaaaac aaaaccaaga ucucuccacc uuuucuuugc uuuuucagac uuuguaauaa     480

ggcccuuugg agugcaggau auucggcagg acaagcagag agggagacca ucaguucuuu     540

cuuugaucaa gaagacuaug uuccuuagca aacuggugug uauuaucucu uaugcaauga     600

gccuggaaag agggcacagc caccgaggau gguacagcau ggauggaugg uacgcuacag     660

agacucggga gcccaacugu gaguggcuga cuggcauggu agguucaggg aagaauuggc     720

cugugaagaa aauguucuug aaaagugaac aaggugcagg agguaggagu ggguccuggg     780

caaagcaggg ggugcauccc agccucaggg aauagcacag cagaggucug uugaugcaug     840

cgagugcaug accugcuugc caauagacga ucaagaaugg gcaaagcauc augggugaug     900

agugggagag gggaugagac auuccuuucu cccugcugag acuuccauug aaccgaugag     960

uucugaauag aagaugcccc cccacccccc caccagugua gaaucugaag ggaggcauau    1020

auuacccuau auuacucugu guuggcggcg agcuaucuga cagccaaccu ucccauacau    1080

uucauugggc auacacuaau gacaggaagu uccuuuugcu uguaugcaag agauggcuca    1140

cacgauggag aauuuaaucu ug                                             1162


<210> 91
<211> 1158
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -40/+0 relative to M76-AUG

<400> 91
caaauagaca cucugcuuuu ugacauucca aaucugguug aucugcagaa uuccagugcu      60

agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg uaaccucgug     120

gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc ugugcaagag     180

cauccagugc ucuuaagugc ugagccaucu cuuuagcucc agucucuuaa aaaacaaaca     240

aacgaacgaa cagcaaggga gcuggguaug acaacacaua cuauaauucu aguacucagg     300

augcugaaac aggaggauug ccugacuggg agauauaagg agaaucuguu gucaccccca     360

ccccucccca uaaaggcaga auaaaagaac guccuauaaa caaauaaaca aacaacccaa     420

uaaaacaaaa ccaagaucuc uccaccuuuu cuuugcuuuu ucagacuuug uaauaaggcc     480

cuuuggagug caggauauuc ggcaggacaa gcagagaggg agaccaucag uucuuucuuu     540

gaucaagaag acuauguucc uuagcaaacu gguguguauu aucucuuaug caaugagccu     600

ggaaagaggg cacagccacc gaggauggua cagcauggau ggaugguacg cuacagagac     660

ucgggagccc aacugugagu ggcugacugg caugguaggu ucagggaaga auuggccugu     720

gaagaaaaug uucuugaaaa gugaacaagg ugcaggaggu aggagugggu ccugggcaaa     780

gcagggggug caucccagcc ucagggaaua gcacagcaga ggucuguuga ugcaugcgag     840

ugcaugaccu gcuugccaau agacgaucaa gaaugggcaa agcaucaugg gugaugagug     900

ggagagggga ugagacauuc cuuucucccu gcugagacuu ccauugaacc gaugaguucu     960

gaauagaaga ugccccccca cccccccacc aguguagaau cugaagggag gcauauauua    1020

cccuauauua cucuguguug gcggcgagcu aucugacagc caaccuuccc auacauuuca    1080

uugggcauac acuaaugaca ggaaguuccu uuugcuugua ugcaagagau ggcucacacg    1140

auggagaauu uaaucuug                                                  1158


<210> 92
<211> 1188
<212> RNA
<213> Artificial Sequence


<220> 
<223> SINEUP-FXN in antisense orientation to FXN mRNA isoform 1; BD=
      -70/+0 relative to M76-AUG

<400> 92
caaauagaca cucugcuuuu ugacauucca aaucugguug aggccacguu gguucgaacu      60

ugcgcggcgg aucugcagaa uuccagugcu agaggagguc agaagagggc auuggauccc     120

ccagaacugg aguuauacgg uaaccucgug gugguuguga accaccaugu ggauggauau     180

ugaguuccaa acacuggucc ugugcaagag cauccagugc ucuuaagugc ugagccaucu     240

cuuuagcucc agucucuuaa aaaacaaaca aacgaacgaa cagcaaggga gcuggguaug     300

acaacacaua cuauaauucu aguacucagg augcugaaac aggaggauug ccugacuggg     360

agauauaagg agaaucuguu gucaccccca ccccucccca uaaaggcaga auaaaagaac     420

guccuauaaa caaauaaaca aacaacccaa uaaaacaaaa ccaagaucuc uccaccuuuu     480

cuuugcuuuu ucagacuuug uaauaaggcc cuuuggagug caggauauuc ggcaggacaa     540

gcagagaggg agaccaucag uucuuucuuu gaucaagaag acuauguucc uuagcaaacu     600

gguguguauu aucucuuaug caaugagccu ggaaagaggg cacagccacc gaggauggua     660

cagcauggau ggaugguacg cuacagagac ucgggagccc aacugugagu ggcugacugg     720

caugguaggu ucagggaaga auuggccugu gaagaaaaug uucuugaaaa gugaacaagg     780

ugcaggaggu aggagugggu ccugggcaaa gcagggggug caucccagcc ucagggaaua     840

gcacagcaga ggucuguuga ugcaugcgag ugcaugaccu gcuugccaau agacgaucaa     900

gaaugggcaa agcaucaugg gugaugagug ggagagggga ugagacauuc cuuucucccu     960

gcugagacuu ccauugaacc gaugaguucu gaauagaaga ugccccccca cccccccacc    1020

aguguagaau cugaagggag gcauauauua cccuauauua cucuguguug gcggcgagcu    1080

aucugacagc caaccuuccc auacauuuca uugggcauac acuaaugaca ggaaguuccu    1140

uuugcuugua ugcaagagau ggcucacacg auggagaauu uaaucuug                 1188


<210> 93
<211> 220
<212> RNA
<213> Artificial Sequence


<220> 
<223> miniSINEUP-FXN in antisense orientation to FXN mRNA; BD= -40/+0
      relative to M1-AUG

<400> 93
gcugcuccgg gucugccgcc cgcuccgccc uccagcgcug aucugcagaa uuccagugcu     60

agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg uaaccucgug    120

gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc ugugcaagag    180

cauccagugc ucuuaagugc ugagccaucu cuuuagcucc                          220


<210> 94
<211> 194
<212> RNA
<213> Artificial Sequence


<220> 
<223> miniSINEUP-FXN in antisense orientation to FXN mRNA; BD= -14/+0
      relative to M1-AUG

<400> 94
gcugcuccgg gucuaucugc agaauuccag ugcuagagga ggucagaaga gggcauugga     60

ucccccagaa cuggaguuau acgguaaccu cguggugguu gugaaccacc auguggaugg    120

auauugaguu ccaaacacug guccugugca agagcaucca gugcucuuaa gugcugagcc    180

aucucuuuag cucc                                                      194


<210> 95
<211> 198
<212> RNA
<213> Artificial Sequence


<220> 
<223> miniSINEUP-FXN in antisense orientation to FXN mRNA; BD= -14/+4
      relative to M1-AUG

<400> 95
acaugcugcu ccgggucuau cugcagaauu ccagugcuag aggaggucag aagagggcau     60

uggauccccc agaacuggag uuauacggua accucguggu gguugugaac caccaugugg    120

auggauauug aguuccaaac acugguccug ugcaagagca uccagugcuc uuaagugcug    180

agccaucucu uuagcucc                                                  198


<210> 96
<211> 224
<212> RNA
<213> Artificial Sequence


<220> 
<223> miniSINEUP-FXN in antisense orientation to FXN mRNA; BD= -40/+4
      relative to M76-AUG

<400> 96
ucaucaaaua gacacucugc uuuuugacau uccaaaucug guugaucugc agaauuccag     60

ugcuagagga ggucagaaga gggcauugga ucccccagaa cuggaguuau acgguaaccu    120

cguggugguu gugaaccacc auguggaugg auauugaguu ccaaacacug guccugugca    180

agagcaucca gugcucuuaa gugcugagcc aucucuuuag cucc                     224


<210> 97
<211> 136
<212> RNA
<213> Artificial Sequence


<220> 
<223> microSINEUP-FXN in antisense orientation to FXN mRNA; BD= -40/+0
      relative to M1-AUG

<400> 97
gcugcuccgg gucugccgcc cgcuccgccc uccagcgcug aucugcagaa uucgcccuug     60

aacuggaguu auacgguaac cucguggugg uugugaacca ccauguggau ggauauugag    120

uuccaaacac uggucc                                                    136


<210> 98
<211> 110
<212> RNA
<213> Artificial Sequence


<220> 
<223> microSINEUP-FXN in antisense orientation to FXN mRNA; BD= -14/+0
      relative to M1-AUG

<400> 98
gcugcuccgg gucuaucugc agaauucgcc cuugaacugg aguuauacgg uaaccucgug     60

gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc               110


