                         SEQUENCE LISTING

<110>  The Governors of the University of Alberta
 
<120>  EXONS 45-55 SKIPPING USING MUTATION-TAILORED COCKTAILS OF 
       ANTISENSE MORPHOLINOS IN THE DMD GENE

<130>  PAT 106444W-90

<150>  US 62/871,797
<151>  2019-07-09

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex43/44_167-12_hDMD_F

<400>  1
gacaagggcg atttgacag                                                    19


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex56_135-154_hDMD_R

<400>  2
tccgaagttc actccacttg                                                   20


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex46_63-83_hDMD_R

<400>  3
tgttatctgc ttcctccaac c                                                 21


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex45_47-65_hDMD_F

<400>  4
tgaatgcaac tggggaaga                                                    19


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex47_59-78_hDMD_R

<400>  5
acttacaagc acgggtcctc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex46_103-122_hDMD_F

<400>  6
acctggaaaa gagcagcaac                                                   20


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex48_106-127_hDMD_R

<400>  7
taggagataa ccacagcagc ag                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex47_63-82_hDMD_F

<400>  8
acccgtgctt gtaagtgctc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex50_23-42_hDMD_R

<400>  9
gtttaccgcc ttccactcag                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex48_153-172_hDMD_F

<400>  10
ccaaccaaac caagaaggac                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex51_76-96_hDMD_R

<400>  11
cctccaacat caaggaagat g                                                 21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex49/50_94-10_hDMD_F

<400>  12
cagccagtga agaggaagtt ag                                                22


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex53_80-99_hDMD_R

<400>  13
ccagccattg tgttgaatcc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex51_188-207_hDMD_F

<400>  14
ggtgggtgac cttgaggata                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex54_125-144_hDMD_R

<400>  15
gcttctccaa gaggcattga                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex53_93-112_hDMD_F

<400>  16
tggctggaag ctaaggaaga                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex55_102-122_hDMD_R

<400>  17
cctgtaggac attggcagtt g                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex54_48-67_hDMD_F

<400>  18
aaatgacttg gccctgaaac                                                   20


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex56_86-104_hDMD_R

<400>  19
aggactgcat catcggaac                                                    19


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGAPDH_662-81_Fwd1

<400>  20
tccctgagct gaacgggaag                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGAPDH_860-79_Rv1

<400>  21
ggaggagtgg gtgtcgctgt                                                   20


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mGapdh_999-1015_Fwd

<400>  22
gctcatttcc tggtatg                                                      17


<210>  23
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mGapdh_1075-91_Rv

<400>  23
tccagggttt cttactc                                                      17


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac2

<400>  24
gtttgccgct gcccaatgcc atcctggagt                                        30


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac9

<400>  25
gacaacagtt tgccgctgcc caatgccatc                                        30


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc4

<400>  26
tgccgctgcc caatgccatc ctgga                                             25


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-2

<400>  27
gccgctgccc aatgccatcc tggagttcct                                        30


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac54

<400>  28
tgaggattgc tgaattattt cttccccagt                                        30


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac40

<400>  29
ttatttcttc cccagttgca ttcaatgttc                                        30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac52

<400>  30
gttatctgct tcctccaacc ataaaacaaa                                        30


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc103

<400>  31
cttttagttg ctgctctttt ccagg                                             25


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac89

<400>  32
gctgctcttt tccaggttca agtgggatac                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac93

<400>  33
agttgctgct cttttccagg ttcaagtggg                                        30


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac79

<400>  34
tccaggttca agtgggatac tagcaatgtt                                        30


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac4

<400>  35
ttccctggcg caggggcaac tcttccacca                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac50

<400>  36
gcacttacaa gcacgggtcc tccagtttca                                        30


<210>  37
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc21

<400>  37
attgtttgag aattccctgg cgcag                                             25


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-18

<400>  38
ttccaccagt aactgaaaca gacaaatgca                                        30


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-9

<400>  39
gggcaactct tccaccagta actgaaacag                                        30


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac59

<400>  40
cttatgggag cacttacaag cacgggtcct                                        30


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac13

<400>  41
gtttgagaat tccctggcgc aggggcaact                                        30


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac3

<400>  42
ttctccttgt ttctcaggta aagctctgga                                        30


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac7

<400>  43
caatttctcc ttgtttctca ggtaaagctc                                        30


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc-2

<400>  44
ttctcaggta aagctctgga aacct                                             25


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac39

<400>  45
ttcaagctgc ccaaggtctt ttatttgagc                                        30


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac78

<400>  46
cagatgattt aactgctctt caaggtcttc                                        30


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac17

<400>  47
atctcttcca catccggttg tttagcttga                                        30


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc23

<400>  48
aatctcttcc acatccggtt gttta                                             25


<210>  49
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac31

<400>  49
gccctttaga caaaatctct tccacatccg                                        30


<210>  50
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac74

<400>  50
cactggctga gtggctggtt tttcc                                             25


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac63

<400>  51
ccactcagag ctcagatctt ctaacttcct                                        30


<210>  52
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac19

<400>  52
acggtttacc gccttccact cagagctcag                                        30


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc47

<400>  53
ctgctttgcc ctcagctctt gaagt                                             25


<210>  54
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac0

<400>  54
gtgtcaccag agtaacagtc tgagtaggag                                        30


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac5

<400>  55
aggttgtgtc accagagtaa cagtctgagt                                        30


<210>  56
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac65:Ete

<400>  56
ctccaacatc aaggaagatg gcatttctag                                        30


<210>  57
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc65

<400>  57
acatcaagga agatggcatt tctag                                             25


<210>  58
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac1

<400>  58
acgcctctgt tccaaatcct gcattgttgc                                        30


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac24

<400>  59
ccaactgggg acgcctctgt tccaaatcct                                        30


<210>  60
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc3

<400>  60
gcctctgttc caaatcctgc attgt                                             25


<210>  61
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac26

<400>  61
cctccggttc tgaaggtgtt cttgtacttc                                        30


<210>  62
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac9_Exon 53

<400>  62
gttcttgtac ttcatcccac tgattctgaa                                        30


<210>  63
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc43

<400>  63
attcaactgt tgcctccggt tctga                                             25


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac42

<400>  64
gagaagtttc agggccaagt catttgccac                                        30


<210>  65
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc22

<400>  65
gccacatcta catttgtctg ccact                                             25


<210>  66
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac0_Exon 55

<400>  66
tcttccaaag cagcctctcg ctcactcacc                                        30


<210>  67
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAc83

<400>  67
gcagttgttt cagcttctgt aagcc                                             25


<210>  68
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac61

<400>  68
actagcaatg ttatctgctt cctccaacca                                        30


<210>  69
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac21

<400>  69
tcatttaaat ctctttgaaa ttctgacaag                                        30


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac119

<400>  70
ccttgacttg ctcaagcttt tcttttagtt                                        30


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac5_Exon 50

<400>  71
gccttccact cagagctcag atcttctaac                                        30


<210>  72
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac68

<400>  72
gtggtcagtc caggagctag gtcaggctgc                                        30


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac35

<400>  73
gccctcagct cttgaagtaa acggtttacc                                        30


<210>  74
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD exon 46

<400>  74
aacaatttta ttcttctttc tccaggctag aagaacaaaa gaatatcttg tcagaatttc       60

aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt gctagtatcc      120

cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc aaggtaattt      180

tattttctca aatccccc                                                    198


<210>  75
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD exon 50

<400>  75
taatgtgtat gcttttctgt taaagaggaa gttagaagat ctgagctctg agtggaaggc       60

ggtaaaccgt ttacttcaag agctgagggc aaagcagcct gacctagctc ctggactgac      120

cactattgga gcctgtaagt atactggatc ccattctct                             159


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex50_Ac19_30mer

<400>  76
gtaaacggtt taccgccttc cactcagagc                                        30


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex52_Ac24

<400>  77
ggtaatgagt tcttccaact ggggacgcct                                        30


