                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  SELF-ASSEMBLING CIRCULAR TANDEM REPEAT PROTEINS WITH INCREASED 
       STABILITY

<130>  F053-0095PCT/19-005-WO-PCT

<150>  US 62/870,005
<151>  2019-07-02

<150>  US 62/984,706
<151>  2020-03-03

<160>  254   

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group  XI

<400>  1

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  2

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  3

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Val Leu 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  4

Ser Glu Glu Ile Leu Glu Leu Leu Val Ala Ala His Leu Leu 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  5

Ser Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  6

Ser Glu Glu Ile Lys Glu Leu Leu Arg Ala Ala His Glu Leu 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  7

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Lys 
1               5                   10                  


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  8

Pro Glu Ala Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  9

Pro Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  10

Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  11

Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  12

Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  13

Pro Glu Leu Glu Tyr Ala Leu Ala Tyr Ala Lys Lys Val 
1               5                   10              


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  14

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala Leu 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  15

Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu Leu 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  16

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly Leu 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  17

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly Gly 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  18

Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Arg Lys 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  19

Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser Phe 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group I

<400>  20

Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu Leu Ser Leu 
1               5                   10                  


<210>  21
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group II

<400>  21

Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val 
1               5                   10                  15      


Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25  


<210>  22
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group II

<400>  22

Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys 
1               5                   10                  15      


Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu 
            20                  25              


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group II

<400>  23

Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp 
1               5                   10                  15      


Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu 
            20                  25          


<210>  24
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group II

<400>  24

Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val 
1               5                   10                  15      


Leu Ala Glu Ile Ala Arg Asp Arg 
            20                  


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group II

<400>  25

Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln 
1               5                   10                  15      


Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys Glu 
            20                  25          


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group II

<400>  26

Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr 
1               5                   10                  15      


Val Leu Ala Glu Ile Ala Arg Asp Arg 
            20                  25  


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  27

Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  28
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  28

Ser Glu Leu Ala Ala Arg Cys Leu Ile Ile Leu Phe Gln Gln Leu Val 
1               5                   10                  15      


Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25  


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  29

Cys Glu Ala Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  30

Cys Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  31

Cys Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  32

Cys Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group III

<400>  33

Cys Glu Leu Glu Tyr Ala Leu Ala Tyr Ala Lys Lys Val 
1               5                   10              


<210>  34

<400>  34
000

<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IV

<400>  35

Ser Glu Leu Ala Cys Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val 
1               5                   10                  15      


Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25  


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IV

<400>  36

Pro Glu Cys Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IV

<400>  37

Pro Glu Cys Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  38

<400>  38
000

<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group V

<400>  39

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  40
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group V

<400>  40

Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25          


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group V

<400>  41

Gly Asp Glu Pro Glu Leu Glu Tyr Ala Leu Ala Tyr Ala Lys Lys Val 
1               5                   10                  15      


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group V

<400>  42

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  43

Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  44

Gly Asn Ser Glu Leu Ala Ala Arg Cys Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25          


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  45

Gly Asp Glu Cys Glu Leu Glu Tyr Ala Leu Ala Tyr Ala Lys Lys Val 
1               5                   10                  15      


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  46

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VII

<400>  47

Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  48
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VII

<400>  48

Gly Asn Ser Glu Leu Ala Cys Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25          


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VII

<400>  49

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  50
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VII

<400>  50

Gly Leu Asn Glu Leu Cys Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser 
            20                  25          


<210>  51
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VII

<400>  51

Gly Leu Asn Glu Leu Cys Leu Lys Ala Leu Gln Ile Leu Val Asn Ala 
1               5                   10                  15      


Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg 
            20                  25          


<210>  52
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group  VIII

<400>  52

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group  VIII

<400>  53

Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp 
            20                  25                  


<210>  54
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group  VIII

<400>  54

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr 
            


<210>  55
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group  VIII

<400>  55

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  56

Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  57

Gly Asn Ser Glu Leu Ala Ala Arg Cys Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp 
            20                  25                  


<210>  58
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  58

Gly Lys Ser Cys Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr 
            


<210>  59
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  59

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  60
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group X

<400>  60

Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  61
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group X

<400>  61

Gly Asn Ser Glu Leu Ala Cys Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp 
            20                  25                  


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group X

<400>  62

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  63
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  63

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Val 
            20                  25                  30          


Leu 
    


<210>  64
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  64

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Val Ala Ala His Leu 
            20                  25                  30          


Leu 
    


<210>  65
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  65

Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  66
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  66

Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu 
            20                  25                  30          


Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg 
        35                  40                  45              


Arg Val Val Glu Gln Ala Leu Arg Glu 
    50                  55          


<210>  67
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  67

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Arg 
            20                  25                  30          


Lys 
    


<210>  68
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  68

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Phe 
    


<210>  69
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  69

Gly Lys Ser Pro Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu Leu Ser 
            20                  25                  30          


Leu 
    


<210>  70
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  70

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  71
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  71

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala 
            20                  25                  30          


Leu 
    


<210>  72
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  72

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  73
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  73

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Leu 
    


<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XI

<400>  74

Gly Leu Asn Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Gly 
    


<210>  75
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  75

Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  76
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  76

Gly Asn Ser Glu Leu Ala Ala Arg Cys Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu 
            20                  25                  30          


Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg 
        35                  40                  45              


Arg Val Val Glu Gln Ala Leu Arg Glu 
    50                  55          


<210>  77
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  77

Gly Lys Ser Cys Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Arg Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Arg 
            20                  25                  30          


Lys 
    


<210>  78
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  78

Gly Lys Ser Cys Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Glu Lys Phe Leu Lys Glu Leu Ser 
            20                  25                  30          


Phe 
    


<210>  79
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  79

Gly Lys Ser Cys Thr Glu Val Leu Leu Glu Leu Ile Ala Glu Ala Ser 
1               5                   10                  15      


Gly Thr Thr Lys Glu Glu Val Lys Lys Lys Phe Trp Lys Glu Leu Ser 
            20                  25                  30          


Leu 
    


<210>  80
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  80

Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Val 
            20                  25                  30          


Leu 
    


<210>  81
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  81

Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Val Ala Ala His Leu 
            20                  25                  30          


Leu 
    


<210>  82
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  82

Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  83
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  83

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  84
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  84

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala 
            20                  25                  30          


Leu 
    


<210>  85
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  85

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  86
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  86

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Leu 
    


<210>  87
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XII

<400>  87

Gly Leu Asn Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Gly 
    


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  88

Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  89
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  89

Gly Asn Ser Glu Leu Ala Cys Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu 
            20                  25                  30          


Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg 
        35                  40                  45              


Arg Val Val Glu Gln Ala Leu Arg Glu 
    50                  55          


<210>  90
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  90

Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Val 
            20                  25                  30          


Leu 
    


<210>  91
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  91

Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Val Ala Ala His Leu 
            20                  25                  30          


Leu 
    


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  92

Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  93
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  93

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  94
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  94

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Ala 
            20                  25                  30          


Leu 
    


<210>  95
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  95

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Ala Glu Ile Leu Glu Leu Leu Met Ala Ala His Glu 
            20                  25                  30          


Leu 
    


<210>  96
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  96

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Leu 
    


<210>  97
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group XIII

<400>  97

Gly Leu Asn Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Gly 
            20                  25                  30          


Gly 
    


<210>  98
<211>  2454
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24 (Single chain cTRP with 24 repeats)

<400>  98
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg acccggaagc gatcaaagcg gctgcggaac tgggcaaagc tggtatctcg      120

tcagaagaaa tcctggaact gctgcgtgcg gcgcatgaac tgggcctgga tccggaagcc      180

attaaagccg cggcggaact gggcaaagcg ggtatcagca gcgaagaaat cctggaactg      240

ctgcgcgcgg cccatgaact gggtctggat ccggaagcca tcaaagccgc ggcggaactg      300

ggcaaagcgg gcatcagcag cgaagaaatc ctggaactgc tgcgcgccgc gcatgaactg      360

ggtctggatc cggaagcgat taaagccgcc gccgaactgg gtaaagcggg tattagcagc      420

gaagaaatcc tggaactgct gcgtgcggcg catgaactgg gcctggatcc ggaagccatc      480

aaagccgccg ccgaactggg taaagccggt atcagcagcg aagaaattct ggaactgctg      540

cgtgccgccc atgaactggg cctggatccg gaagcgatta aagccgccgc ggaactgggt      600

aaagccggta ttagcagcga agaaatcctg gaactgctgc gtgccgcgca tgaactgggt      660

ctggatccgg aagccatcaa agcggcggcc gaactgggta aagccggcat cagcagcgaa      720

gaaatcctgg aactgctgcg tgccgcccat gaactgggcc tggatccgga agcgatcaaa      780

gccgccgcgg aactgggtaa agccggcatt agcagcgaag aaatcctgga actgctgcgt      840

gccgcgcatg aactgggtct ggatccggaa gcgattaaag cggcggccga actgggcaaa      900

gccggtatta gcagcgaaga aatcctggaa ctgctgcgtg cggcccatga actgggcctg      960

gatccggaag cgatcaaagc ggcggccgaa ctgggtaaag cgggtatcag cagcgaagaa     1020

atcctggaac tgctgcgtgc cgcccatgaa ctgggtctgg atccggaagc cattaaagcg     1080

gcggcggaac tgggtaaagc gggcatcagc agcgaagaaa ttctggaact gctgcgcgcg     1140

gcgcatgaac tgggtctgga tccggaagcc attaaagccg ccgcggaact gggcaaagcg     1200

ggtattagca gcgaagaaat tctggaactg ctgcgcgcgg cgcatgaact gggcctggat     1260

ccggaagcga ttaaagccgc cgccgaactg ggcaaagccg gcatcagcag cgaagaaatt     1320

ctggaactgc tgcgcgccgc ccatgaactg ggcctggatc cggaagcgat caaagccgcc     1380

gcggaactgg gcaaagcggg catcagcagc gaagaaatcc tggaactgct gcgtgcggcg     1440

catgaactgg gtctggatcc ggaagccatt aaagccgcgg cggaactggg caaagccggc     1500

attagcagcg aagaaattct ggaactgctg cgtgcggcgc atgaactggg tctggatccg     1560

gaagccatca aagccgcggc ggaactgggt aaagcgggta ttagcagcga agaaattctg     1620

gaactgctgc gcgcggccca tgaactgggc ctggatccgg aagcgattaa agcggcggcc     1680

gaactgggca aagcgggcat tagcagcgaa gaaatcctgg aactgctgcg cgcggcgcat     1740

gaactgggtc tggatccgga agccattaaa gccgccgccg aactgggcaa agccggtatc     1800

agcagcgaag aaattctgga actgctgcgc gcggcccatg aactgggtct ggatccggaa     1860

gccatcaaag ccgccgcgga actgggtaaa gccggtatca gcagcgaaga aatcctggaa     1920

ctgctgcgcg ccgcccatga actgggcctg gatccggaag cgatcaaagc cgcggcggaa     1980

ctgggtaaag cgggcattag cagcgaagaa attctggaac tgctgcgtgc ggcccatgaa     2040

ctgggtctgg atccggaagc gatcaaagcc gcggccgaac tgggtaaagc gggcatcagc     2100

agcgaagaaa ttctggaact gctgcgtgcc gcgcatgaac tgggcctgga tccggaagcg     2160

attaaagccg cggccgaact gggcaaagcg ggcattagca gcgaagaaat tctggaactg     2220

ctgcgcgcgg cgcatgaact gggcctggat ccggaagcga ttaaagcggc ggccgaactg     2280

ggcaaagcgg gtatcagcag cgaagaaatc ctggaactgc tgcgcgccgc gcatgaactg     2340

ggcctggatc cggaagcgat taaagccgcg gccgaactgg gcaaagcggg tatctcgtct     2400

gaagaaatcc tggaactgct gcgtgctgcc catgaactgg gtggttggta ataa           2454


<210>  99
<211>  816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24 (Single chain cTRP with 24 repeats)

<400>  99

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    210                 215                 220                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
225                 230                 235                 240 


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                245                 250                 255     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            260                 265                 270         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        275                 280                 285             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    290                 295                 300                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
305                 310                 315                 320 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                325                 330                 335     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            340                 345                 350         


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        355                 360                 365             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    370                 375                 380                 


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
385                 390                 395                 400 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
                405                 410                 415     


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
            420                 425                 430         


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
        435                 440                 445             


Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
    450                 455                 460                 


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
465                 470                 475                 480 


His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu 
                485                 490                 495     


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
            500                 505                 510         


Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
        515                 520                 525             


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
    530                 535                 540                 


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
545                 550                 555                 560 


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
                565                 570                 575     


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
            580                 585                 590         


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
        595                 600                 605             


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
    610                 615                 620                 


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
625                 630                 635                 640 


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
                645                 650                 655     


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
            660                 665                 670         


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
        675                 680                 685             


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
    690                 695                 700                 


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
705                 710                 715                 720 


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
                725                 730                 735     


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
            740                 745                 750         


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
        755                 760                 765             


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
    770                 775                 780                 


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
785                 790                 795                 800 


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
                805                 810                 815     


<210>  100
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub3 (Sub3 cTRP construct containing 3 repeats)

<400>  100
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg atccggaagc tattaaagcg gcggcagaac tgggcaaagc cggtattagc      120

tctgaagaaa tcctggaact gctgcgtgct gcgcatgaac tgggtctgga cccggaagca      180

atcaaagccg cagctgaact gggcaaagcg ggtattagtt ccgaagaaat tctggaactg      240

ctgcgtgccg cacatgaact gggtctggat ccggaagcca ttaaagcagc tgcggaactg      300

ggtaaagccg gtattagcag cgaggagatt ctggaactgc tgcgcgccgc acatgaactg      360

ggcggttggt aa                                                          372


<210>  101
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub3 (Sub3 cTRP construct containing 3 repeats)

<400>  101

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
        115                 120             


<210>  102
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub4 (Sub4 cTRP construct containing 4 repeats)

<400>  102
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg atccggaagc gattaaagcg gcggcagaac tgggcaaagc cggtattagc      120

tctgaagaaa tcctggaact gctgcgtgct gcgcatgaac tgggtctgga cccggaagca      180

atcaaagccg cagctgaact gggcaaagct ggtattagtt ccgaagaaat tctggaactg      240

ctgcgtgccg cacatgaact gggtctggat ccggaagcca tcaaagcagc tgcggaactg      300

ggtaaagcgg gtatttcatc ggaggagatc ctggaactgc tgcgcgcggc ccacgaactg      360

ggcctggatc cggaagctat caaagctgcg gccgaactgg gtaaagctgg tattagcagc      420

gaggagattc tggaactgct gcgcgcagct cacgaactgg gcggttggta a               471


<210>  103
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub4 (Sub4 cTRP construct containing 4 repeats)

<400>  103

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
145                 150                 155     


<210>  104
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6 (Sub6 cTRP construct containing 6 repeats)

<400>  104
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg atccggaagc aattaaagcg gcggcagaac tgggcaaagc tggtattagc      120

tctgaagaaa tcctggaact gctgcgtgct gcgcatgaac tgggtctgga cccggaagca      180

atcaaagccg cagctgaact gggcaaagcg ggtattagtt ccgaagaaat tctggaactg      240

ctgcgtgccg cacatgaact gggtctggat ccggaagcca ttaaagcagc tgcggaactg      300

ggcaaagcag gtatttcatc ggaggagatc ctggaactgc tgcgcgcggc ccacgaactg      360

ggcctggacc cggaagcgat caaagctgcg gccgaactgg gcaaagccgg catctctagc      420

gaggagattc tggaactgct gcgcgcagct cacgaactgg gcctggatcc ggaagcgatc      480

aaggcggcgg cagagctggg caaagccggt attagttcag aggagatact ggaactgctg      540

cgcgccgccc acgagttagg tctggatccg gaagcgatta aggccgcagc tgagctgggt      600

aaagccggta ttagctccga ggagatatta gaactgctgc gtgccgcgca tgaactgggc      660

ggttggtaa                                                              669


<210>  105
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6 (Sub6 cTRP construct containing 6 repeats)

<400>  105

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
    210                 215                 220         


<210>  106
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub8 (Sub8 cTRP construct containing 8 repeats)

<400>  106
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg atccggaagc gattaaagcg gcggcagaac tgggcaaagc cggtattagc      120

tctgaagaaa tcctggaact gctgcgtgct gcgcatgaac tgggtctgga cccggaagca      180

atcaaagccg cagctgaact gggcaaagct ggtattagtt ccgaagaaat tctggaactg      240

ctgcgtgccg cacatgaact gggtctggat ccggaagcaa ttaaagcagc tgcggaactg      300

ggcaaagcgg gtatttcatc ggaggagatc ctggaactgc tgcgcgccgc acatgtgctg      360

ggcctggatc cggaagccat caaagctgcg gccgaactgg gcaaagcagg catctctagc      420

gaggagattc tggaactgct ggttgcagct cacctgctgg gtttagaccc tgaagccatc      480

aaggcggcgg cagagctggg taaagcgggc atcagttccg aggagatact ggaactgctg      540

cgcgcggccc acgaactggg cctggacccg gaagcgatta aggccgcagc tgagctgggt      600

aaagcgggta tcagctcgga ggagatatta gaactgctgc gcgccgccca tgagttaggc      660

ctggacccgg aagccatcaa ggcagctgcg gagctgggta aagctggcat ctctagcgag      720

gaaattttag agctgctgcg tgcggcccac gagttaggtc tggacccgga agccattaag      780

gctgcggccg agctgggcaa agcgggtatc tcatccattg agatattgga gctgctgcgt      840

gcagctcacg aactgggcgg ttggtaa                                          867


<210>  107
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub8 (Sub8 cTRP construct containing 8 repeats)

<400>  107

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Val Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Val Ala Ala His Leu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    210                 215                 220                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
225                 230                 235                 240 


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                245                 250                 255     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            260                 265                 270         


Ile Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
        275                 280                 285             


<210>  108
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12 (cTRP construct containing 12 repeats)

<400>  108
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg acccggaggc gatcaaggct gcggcggaac tgggtaaagc gggcatcagc      120

agcgaggaaa ttctggagct gctgcgtgcg gcgcatgagc tgggtctgga cccggaagcg      180

attaaggctg cggcggagct gggcaaggcg ggtatcagca gcgaagaaat tctggaactg      240

ctgcgcgcgg cgcatgagct gggcctggac ccggaagcga tcaaagctgc ggcggagctg      300

ggtaaggctg gtatcagcag cgaggagatt ctggaattat tacgcgcggc gcatgaactg      360

ggtctggacc cggaggcgat taaagctgcg gcggaactgg gcaaggcggg catcagcagc      420

gaagagattc tggaattact tcgtgctgcg catgaactgg gcctggaccc ggaggctatt      480

aaggctgcgg cggaattagg caaagctggc atcagcagcg aagaaattct ggaattactg      540

cgtgccgctc atgaattagg tctggacccg gaagctatca aagctgcggc ggaattaggt      600

aaggccggta tcagcagcga ggaaattctg gaattgttac gagctgctca tgaattaggc      660

ctggacccgg aggccattaa ggctgcggcg gagttaggca aagcgggtat cagcagcgag      720

gaaattctgg aacttttacg agctgctcat gagttaggtc tggacccgga ggctatcaag      780

gctgcggcgg agttgggcaa agccggcatc agcagcgagg agattctgga acttttacgg      840

gctgctcatg aacttggcct ggacccggag gcaattaagg ctgcggcgga gctaggcaag      900

gctggtatca gcagcgagga aattctggaa ctactgcgtg ccgcccatga attgggtctg      960

gacccggaag caatcaaggc tgcggcggag cttggcaagg ccggtatcag cagcgaggaa     1020

attctggaac tgttacgagc tgcccatgaa cttggtctgg acccggaagc cataaaagct     1080

gcggcggagt taggtaaggc aggtatcagc agcgaggaaa ttctggaact cctgcgtgcc     1140

gcacatgaac tcggtctgga cccggaggcc attaaagctg cggcggagtt gggtaaggcg     1200

ggtatcagca gcgaggaaat tctggagtta ctgcgtgccg cgcatgagct gggtggctgg     1260

taataa                                                                1266


<210>  109
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12 (cTRP construct containing 12 repeats)

<400>  109

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    210                 215                 220                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
225                 230                 235                 240 


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                245                 250                 255     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            260                 265                 270         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        275                 280                 285             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    290                 295                 300                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
305                 310                 315                 320 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                325                 330                 335     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            340                 345                 350         


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        355                 360                 365             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    370                 375                 380                 


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
385                 390                 395                 400 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
                405                 410                 415     


Leu Gly Gly Trp 
            420 


<210>  110
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12SS (cTRP construct containing 12 repeats and 
       disulfide staples)

<400>  110
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg actgcgaggc gatcaaggct gcggcggaac tgggtaaagc gggcatcagc      120

agcgaggaaa ttctggagct gctgcgtgcg gcgcatgagc tgggtctgga cccggaagcg      180

attaaggctg cggcggagct gggcaaggcg ggtatcagca gcgaagaaat tctggaactg      240

ctgcgcgcgg cgcatgagct gggcctggac ccggaagcga tcaaagctgc ggcggagctg      300

ggtaaggctg gtatcagcag cgaggagatt ctggaattat tacgcgcggc gcatgaactg      360

ggtctggacc cggaggcgat taaagctgcg gcggaactgg gcaaggcggg catcagcagc      420

gaagagattc tggaattact tcgtgctgcg catgaactgg gcctggaccc ggaggctatt      480

aaggctgcgg cggaattagg caaagctggc atcagcagcg aagaaattct ggaattactg      540

cgtgccgctc atgaattagg tctggacccg gaagctatca aagctgcggc ggaattaggt      600

aaggccggta tcagcagcga ggaaattctg gaattgttac gagctgctca tgaattaggc      660

ctggacccgg aggccattaa ggctgcggcg gagttaggca aagcgggtat cagcagcgag      720

gaaattctgg aacttttacg agctgctcat gagttaggtc tggacccgga ggctatcaag      780

gctgcggcgg agttgggcaa agccggcatc agcagcgagg agattctgga acttttacgg      840

gctgctcatg aacttggcct ggacccggag gcaattaagg ctgcggcgga gctaggcaag      900

gctggtatca gcagcgagga aattctggaa ctactgcgtg ccgcccatga attgggtctg      960

gacccggaag caatcaaggc tgcggcggag cttggcaagg ccggtatcag cagcgaggaa     1020

attctggaac tgttacgagc tgcccatgaa cttggtctgg acccggaagc cataaaagct     1080

gcggcggagt taggtaaggc aggtatcagc agcgaggaaa ttctggaact cctgcgtgcc     1140

gcacatgaac tcggtctgga cccggaatgc ataaaggctg cggcggaatt gggcaaagct     1200

ggtatcagca gcgaggaaat tctggagtta ctgcgtgccg cgcatgagct gggtggctgg     1260

taataa                                                                1266


<210>  111
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12SS (cTRP construct containing 12 repeats and 
       disulfide staples)

<400>  111

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    210                 215                 220                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
225                 230                 235                 240 


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                245                 250                 255     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            260                 265                 270         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        275                 280                 285             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    290                 295                 300                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
305                 310                 315                 320 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                325                 330                 335     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            340                 345                 350         


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        355                 360                 365             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    370                 375                 380                 


Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
385                 390                 395                 400 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
                405                 410                 415     


Leu Gly Gly Trp 
            420 


<210>  112
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12_capped (cTRP construct containing 12 repeats and 
       mutations blocking dimerization)

<400>  112
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg acccggaggc ggaaaaggct gcggcggagc tgggtaaagc gggcatcagc      120

agcgaggaaa ttaaagaact gctgcgtgcg gcgcatgagc tgggtctgga cccggaagcg      180

atcaaagctg cggcggaact gggcaaggcg ggtatcagca gcgaagaaat tctggaactg      240

ctgcgcgcgg cgcatgagct gggcctggac ccggaagcga ttaaagctgc ggcggagctg      300

ggcaaggcgg gcatcagcag cgaagagatt ctggaattat tacgcgcggc gcatgaactg      360

ggtctggacc cggaggcgat caaggctgcg gcggaactgg gtaaggctgg tatcagcagc      420

gaggagattc tggaattact tcgtgctgcg catgaactgg gcctggaccc ggaggcgatt      480

aaggctgcgg cggagttagg caaagctggc atcagcagcg aagaaattct ggaattactg      540

cgtgccgctc atgaattagg tctggacccg gaagctatca aggctgcggc ggagttgggc      600

aaagccggca tcagcagcga ggagattctg gaacttttac gagctgctca tgaattaggc      660

ctggacccgg aagctattaa agctgcggcg gaattaggta aggccggtat cagcagcgag      720

gaaattctgg aattgttacg agctgctcat gagttaggtc tggacccgga ggctatcaaa      780

gctgcggcgg agttaggtaa ggcaggtatc agcagcgagg aaattctgga acttttacgg      840

gctgctcatg aacttggcct ggacccggaa gccatcaaag ctgcggcgga attagggaaa      900

gctggaatca gcagcgaaga gattctggaa cttcttcgtg ccgctcatga acttggtctg      960

gacccggagg ccattaaagc tgcggcggaa cttggtaagg cgggtatcag cagcgaggaa     1020

attctggaac tactgcgtgc cgcccatgaa ttgggtctgg acccggaagc aatcaaggct     1080

gcggcggagc ttggcaaagc aggtatcagc agcgaggaaa ttctggagtt attgcgtgcc     1140

gctcatgaac tcggtctgga cccggaagcc atcaagaaag cggcggaact gggcaaagca     1200

ggcatcagca gcgaagagat tctggagctg ctgcgtgcgg cgcacgaaaa aggtggctgg     1260

taataa                                                                1266


<210>  113
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12_capped (cTRP construct containing 12 repeats and 
       mutations blocking dimerization)

<400>  113

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Pro Glu Ala Glu Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Lys Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    210                 215                 220                 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
225                 230                 235                 240 


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                245                 250                 255     


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            260                 265                 270         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        275                 280                 285             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    290                 295                 300                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
305                 310                 315                 320 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                325                 330                 335     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            340                 345                 350         


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        355                 360                 365             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    370                 375                 380                 


Gly Leu Asp Pro Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
385                 390                 395                 400 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
                405                 410                 415     


Lys Gly Gly Trp 
            420 


<210>  114
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6SS (Sub6SS cTRP construct containing 6 repeats and 
       disulfide staples)

<400>  114
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg actgcgaggc cattaaggct gcggcggagt taggcaaagc gggtatcagc      120

agcgaggaaa ttctggaact tttacgagct gctcatgagt taggtctgga cccggaggct      180

atcaaggctg cggcggagtt gggcaaagcc ggcatcagca gcgaggagat tctggaactt      240

ttacgggctg ctcatgaact tggcctggac ccggaggcaa ttaaggctgc ggcggagcta      300

ggcaaggctg gtatcagcag cgaggaaatt ctggaactac tgcgtgccgc ccatgaattg      360

ggtctggacc cggaagcaat caaggctgcg gcggagcttg gcaaggccgg tatcagcagc      420

gaggaaattc tggaactgtt acgagctgcc catgaacttg gtctggaccc ggaagccata      480

aaagctgcgg cggagttagg taaggcaggt atcagcagcg aggaaattct ggaactcctg      540

cgtgccgcac atgaactcgg tctggacccg gagtgcatta aagctgcggc ggagttgggt      600

aaggcgggta tcagcagcga ggaaattctg gagttactgc gtgccgcgca tgagctgggt      660

ggctggtaa                                                              669


<210>  115
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6SS (Sub6SS cTRP construct containing 6 repeats and 
       disulfide staples)

<400>  115

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
145                 150                 155                 160 


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
                165                 170                 175     


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Cys 
            180                 185                 190         


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        195                 200                 205             


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Gly Trp 
    210                 215                 220         


<210>  116
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thick cTRP sub3

<400>  116

Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val Asn Ala 
1               5                   10                  15      


Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu Glu Leu 
            20                  25                  30          


Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln Ala Glu 
        35                  40                  45              


Glu Ile Ala Arg Gln Ala Arg Lys Glu Gly Asn Leu Glu Leu Ala Leu 
    50                  55                  60                  


Lys Ala Leu Gln Ile Leu Val Asn Ala Ala Tyr Val Leu Ala Glu Ile 
65                  70                  75                  80  


Ala Arg Asp Arg Gly Asn Glu Glu Leu Leu Glu Lys Ala Ala Arg Leu 
                85                  90                  95      


Ala Glu Glu Ala Ala Arg Gln Ala Glu Glu Ile Ala Arg Gln Ala Arg 
            100                 105                 110         


Lys Glu Gly Asn Leu Glu Leu Ala Leu Lys Ala Leu Gln Ile Leu Val 
        115                 120                 125             


Asn Ala Ala Tyr Val Leu Ala Glu Ile Ala Arg Asp Arg Gly Asn Glu 
    130                 135                 140                 


Glu Leu Leu Glu Lys Ala Ala Arg Leu Ala Glu Glu Ala Ala Arg Gln 
145                 150                 155                 160 


Ala Glu Glu Ile Ala Arg Gln Ala Arg Lys Glu Gly 
                165                 170         


<210>  117
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thick cTRP sub6

<400>  117

Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu 
            20                  25                  30          


Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg 
        35                  40                  45              


Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala 
    50                  55                  60                  


Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu 
65                  70                  75                  80  


Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp 
                85                  90                  95      


Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu 
            100                 105                 110         


Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe 
        115                 120                 125             


Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu 
    130                 135                 140                 


Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp 
145                 150                 155                 160 


Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu 
                165                 170                 175     


Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala 
            180                 185                 190         


Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser 
        195                 200                 205             


Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln 
    210                 215                 220                 


Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly 
                245                 250                 255     


Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile 
            260                 265                 270         


Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser 
        275                 280                 285             


Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu 
    290                 295                 300                 


Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg 
305                 310                 315                 320 


Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val 
                325                 330                 335     


Glu Gln Ala Leu Arg Glu 
            340         


<210>  118
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thick cTRP sub8

<400>  118

Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu 
            20                  25                  30          


Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg 
        35                  40                  45              


Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala 
    50                  55                  60                  


Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu 
65                  70                  75                  80  


Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp 
                85                  90                  95      


Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu 
            100                 105                 110         


Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe 
        115                 120                 125             


Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu 
    130                 135                 140                 


Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp 
145                 150                 155                 160 


Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu 
                165                 170                 175     


Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala 
            180                 185                 190         


Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser 
        195                 200                 205             


Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln 
    210                 215                 220                 


Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly 
                245                 250                 255     


Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile 
            260                 265                 270         


Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser 
        275                 280                 285             


Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu 
    290                 295                 300                 


Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg 
305                 310                 315                 320 


Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val 
                325                 330                 335     


Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu 
            340                 345                 350         


Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu 
        355                 360                 365             


Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu 
    370                 375                 380                 


Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly 
385                 390                 395                 400 


Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu 
                405                 410                 415     


Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu 
            420                 425                 430         


Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg 
        435                 440                 445             


Val Val Glu Gln Ala Leu Arg Glu Gly 
    450                 455         


<210>  119
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thick cTRP sub8

<400>  119

Gly Asn Ser Glu Leu Ala Ala Arg Cys Leu Ile Ile Leu Phe Gln Gln 
1               5                   10                  15      


Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu 
            20                  25                  30          


Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg 
        35                  40                  45              


Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala 
    50                  55                  60                  


Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu 
65                  70                  75                  80  


Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp 
                85                  90                  95      


Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu 
            100                 105                 110         


Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe 
        115                 120                 125             


Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu 
    130                 135                 140                 


Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp 
145                 150                 155                 160 


Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu 
                165                 170                 175     


Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala 
            180                 185                 190         


Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser 
        195                 200                 205             


Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln 
    210                 215                 220                 


Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly 
                245                 250                 255     


Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile 
            260                 265                 270         


Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser 
        275                 280                 285             


Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu 
    290                 295                 300                 


Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg 
305                 310                 315                 320 


Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val 
                325                 330                 335     


Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu 
            340                 345                 350         


Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu 
        355                 360                 365             


Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu 
    370                 375                 380                 


Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly 
385                 390                 395                 400 


Asn Ser Glu Leu Ala Cys Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu 
                405                 410                 415     


Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu 
            420                 425                 430         


Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg 
        435                 440                 445             


Val Val Glu Gln Ala Leu Arg Glu Gly 
    450                 455         


<210>  120
<211>  1947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12_Spy (cTRP Construct containing 12 repeats and 
       inserted fusions of spycatcher domains)

<400>  120
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg acccggaagc gattaaggcg gcggcggaac tgggcaaggc gggcattagc      120

agcgaggaga ttctggaact gctgcgtgcg gcgcatgagt tgggtctgga cccggaagcc      180

attaaggcag cggccgagct gggcaaggcc ggtatttcca gcgaggagat cttggaactg      240

ttgcgtgctg cacacgagct gggcctggac ccggaagcta ttaaagcggc tgcggagctg      300

ggtaaagctg gtatctccag cgaagaaatt ttggagttgc tgcgtgcggc acacgaactg      360

ggtggttccg acggtcaaga caaaggttcc gatggccaag acaagggtgg tgactccgcg      420

acccatatta aattttctaa gcgcgacgag gatggcaagg aattggcagg cgcgacgatg      480

gaactgcgcg attccagcgg caagaccatc tccacctgga tctctgacgg tcaggtgaaa      540

gatttttatc tgtacccggg taagtacacg ttcgtggaga cggcagcccc ggatggttat      600

gaggtggcca ccgcgatcac cttcacggtt aatgagcagg gccaggtcac cgttaatggt      660

ggctccgatg gtcaggataa gggttccgac ggtcaagata agggtggttt ggatccggag      720

gccatcaagg cggcagcaga gctgggcaaa gcgggcattt ccagcgaaga aatcctggag      780

ctgctgcgcg ctgctcacga actgggcttg gacccggagg cgatcaaagc agcagcggaa      840

ttgggcaaag cgggtattag ctctgaggaa atcctggaat tgttgcgtgc agcgcacgag      900

ctgggtttgg acccggaagc gattaaagcg gcggcggagt tgggtaaagc aggcattagc      960

agcgaagaga ttctggaact gttgcgtgcg gcacatgaac tgggtttgga tccggaggca     1020

attaaggccg ctgcagaact gggcaaggca ggtattagct ccgaagagat tctggaattg     1080

ctgcgcgcgg cgcacgaact gggtctggat ccggaagcaa ttaaggcggc agcagagctg     1140

ggtaaggcgg gtatctcttc tgaggagatc ctggagttgc tgcgtgcggc acacgaattg     1200

ggtctggatc cggaggcaat taaggctgcg gcggagctgg gcaaggcggg tatttcctcc     1260

gaggaaatct tggaactgct gcgcgcagca cacgaactgg gcggctctga cggtcaggat     1320

aaaggctccg acggccagga taaaggcggc gattccgcga cccacattaa atttagcaaa     1380

cgtgacgaag atggtaaaga gctggcaggt gcgacgatgg agctgcgcga tagctccggt     1440

aaaaccatca gcacctggat cagcgacggt caagttaagg acttctatct gtatccgggc     1500

aagtatacgt tcgtggaaac cgcagccccg gacggttacg aagtggctac cgcgattacc     1560

ttcaccgtga acgaacaggg ccaggtgacc gtcaacggcg gctctgacgg ccaagataaa     1620

ggctctgatg gccaggacaa gggcggcttg gacccggagg cgatcaaagc agccgcggag     1680

ttgggtaaag cgggcatctc tagcgaagag attttggagc tgttgcgtgc tgcgcacgag     1740

ctgggcttgg acccggaggc cattaaggcg gcagctgaac tgggtaaagc tggcattagc     1800

tccgaagaga tcttggagct gctgcgtgcc gcgcacgaat tgggcctgga tccggaagca     1860

atcaaggcag ctgctgagtt gggtaaggca ggcatcagca gcgaagaaat cctggaactg     1920

ctgcgtgcgg cgcatgaact gggttaa                                         1947


<210>  121
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12_Spy (cTRP Construct containing 12 repeats and 
       inserted fusions of spycatcher domains)

<400>  121

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Gly Ser Asp Gly Gln Asp Lys 
        115                 120                 125             


Gly Ser Asp Gly Gln Asp Lys Gly Gly Asp Ser Ala Thr His Ile Lys 
    130                 135                 140                 


Phe Ser Lys Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp 
                165                 170                 175     


Gly Gln Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val 
            180                 185                 190         


Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe 
        195                 200                 205             


Thr Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Gly Ser Asp Gly 
    210                 215                 220                 


Gln Asp Lys Gly Ser Asp Gly Gln Asp Lys Gly Gly Leu Asp Pro Glu 
225                 230                 235                 240 


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
                245                 250                 255     


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
            260                 265                 270         


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
        275                 280                 285             


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
    290                 295                 300                 


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
305                 310                 315                 320 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
                325                 330                 335     


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
            340                 345                 350         


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
        355                 360                 365             


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
    370                 375                 380                 


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
385                 390                 395                 400 


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
                405                 410                 415     


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
            420                 425                 430         


Leu Gly Gly Ser Asp Gly Gln Asp Lys Gly Ser Asp Gly Gln Asp Lys 
        435                 440                 445             


Gly Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp 
    450                 455                 460                 


Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly 
465                 470                 475                 480 


Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr 
                485                 490                 495     


Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly 
            500                 505                 510         


Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln 
        515                 520                 525             


Val Thr Val Asn Gly Gly Ser Asp Gly Gln Asp Lys Gly Ser Asp Gly 
    530                 535                 540                 


Gln Asp Lys Gly Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
545                 550                 555                 560 


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
                565                 570                 575     


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
            580                 585                 590         


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        595                 600                 605             


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala 
    610                 615                 620                 


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
625                 630                 635                 640 


Leu Arg Ala Ala His Glu Leu Gly 
                645             


<210>  122
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12SS_SH2 (cTRP Construct containing 12 repeats and 
       inserted fusions of SH2 domains)

<400>  122
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg attgcgaggc gatcaaagcg gcggcggaac tgggtaaagc gggtattagc      120

agcgaggaga ttctggaact gctgcgtgcg gcgcacgagt tgggtttgga tccggaagcc      180

atcaaggctg ccgccgaact gggcaaggca ggtattagct ctgaagagat cttggaactg      240

ctgcgcgccg cgcatgagtt gggtctggat ccggaagcga tcaaggctgc agcagaactg      300

ggcaaagcgg gtatttccag cgaggaaatt ctggagttgc tgcgtgcggc gcatgaattg      360

ggtggctccg atggtcagga taaaggttct gatggccaag ataagggcgg ctccgagtgg      420

tactacggca acgttacgcg ccaccaagca gagtgcgctc tgaatgaacg cggtgttgag      480

ggcgacttcc tgatccgtga tagcgaatct tccccgagcg acttcagcgt ttccctgaag      540

gcgtctggca agaacaagca ctttaaagtt cagctggtcg ataatgtcta ctgcatcggt      600

caacgtcgtt tccacacgat ggacgagttg gtggagcatt ataaaaaggc tccgatcttc      660

acgagcgagc atggtgagaa attgtacctg gtgcgcgcgc tgcagggcgg cagcgacggc      720

caggataaag gctccgacgg ccaagacaag ggtggtttgg acccggaggc gatcaaggca      780

gcagccgaac tgggtaaagc cggtatctct agcgaagaaa ttctggaact gctgcgtgcg      840

gctcatgagc tgggcttgga tccggaggct attaaggccg ctgcggaact gggtaaagct      900

ggcatctcct ccgaagaaat tttggagctg ttgcgtgccg cacatgagtt gggtctggat      960

ccggaagcga ttaaagccgc cgccgaattg ggcaaagcgg gcattagcag cgaagagatt     1020

ttggagctgt tgcgtgcagc gcatgaattg ggcctggacc cggaagcaat caaagcggct     1080

gcagagttgg gtaaggcggg catttctagc gaggagattt tggaactgct gcgcgcagcg     1140

catgagctgg gcctggaccc ggaggccatt aaggcggctg cggaattggg caaggccggt     1200

atttccagcg aagaaattct ggagctgctg cgtgcagctc acgagttggg cttggatccg     1260

gaagccatta aggctgccgc ggaactgggt aaggccggca ttagcagcga ggagatcttg     1320

gagctgctgc gtgccgcgca cgagttgggc ggttctgatg gccaggataa gggttccgat     1380

ggccaggaca aaggcggctc cgaatggtat tatggtaacg tgacccgcca ccaggctgag     1440

tgcgccctga acgagcgtgg cgtcgaaggt gactttctga tccgcgatag cgagagcagc     1500

ccgagcgatt ttagcgtgag cctgaaggca tctggcaaaa acaaacactt taaagtgcaa     1560

ttggtggata acgtttactg catcggccaa cgtcgttttc atacgatgga cgaactggtg     1620

gaacattata agaaggcgcc gatttttacg tccgaacacg gtgaaaaact gtacctggtc     1680

cgtgcattgc agggtggttc cgacggccag gacaaaggtt ccgacggcca agataaaggc     1740

ggtctggacc cggaggcaat caaggctgcg gctgagttgg gcaaggctgg tatcagcagc     1800

gaggaaatcc tggagctgtt gcgcgcggcc catgaactgg gtttggatcc ggaagctatc     1860

aaggctgcgg cagagctggg caaggcgggt atcagctctg aggaaatctt ggagttgctg     1920

cgtgccgcac acgaactggg cctggatccg gaatgtatca aagcggcggc ggagctgggt     1980

aaagcgggca ttagcagcga agaaatcctg gaactgctgc gtgcggcgca tgaactgggt     2040

ggttggtaat aa                                                         2052


<210>  123
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub12SS_SH2 (cTRP Construct containing 12 repeats and 
       inserted fusions of SH2 domains)

<400>  123

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Gly Ser Asp Gly Gln Asp Lys 
        115                 120                 125             


Gly Ser Asp Gly Gln Asp Lys Gly Gly Ser Glu Trp Tyr Tyr Gly Asn 
    130                 135                 140                 


Val Thr Arg His Gln Ala Glu Cys Ala Leu Asn Glu Arg Gly Val Glu 
145                 150                 155                 160 


Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Ser Asp Phe Ser 
                165                 170                 175     


Val Ser Leu Lys Ala Ser Gly Lys Asn Lys His Phe Lys Val Gln Leu 
            180                 185                 190         


Val Asp Asn Val Tyr Cys Ile Gly Gln Arg Arg Phe His Thr Met Asp 
        195                 200                 205             


Glu Leu Val Glu His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu His 
    210                 215                 220                 


Gly Glu Lys Leu Tyr Leu Val Arg Ala Leu Gln Gly Gly Ser Asp Gly 
225                 230                 235                 240 


Gln Asp Lys Gly Ser Asp Gly Gln Asp Lys Gly Gly Leu Asp Pro Glu 
                245                 250                 255     


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
            260                 265                 270         


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
        275                 280                 285             


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
    290                 295                 300                 


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
305                 310                 315                 320 


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
                325                 330                 335     


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
            340                 345                 350         


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
        355                 360                 365             


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
    370                 375                 380                 


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
385                 390                 395                 400 


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
                405                 410                 415     


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
            420                 425                 430         


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
        435                 440                 445             


Leu Gly Gly Ser Asp Gly Gln Asp Lys Gly Ser Asp Gly Gln Asp Lys 
    450                 455                 460                 


Gly Gly Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His Gln Ala Glu 
465                 470                 475                 480 


Cys Ala Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu Ile Arg Asp 
                485                 490                 495     


Ser Glu Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys Ala Ser Gly 
            500                 505                 510         


Lys Asn Lys His Phe Lys Val Gln Leu Val Asp Asn Val Tyr Cys Ile 
        515                 520                 525             


Gly Gln Arg Arg Phe His Thr Met Asp Glu Leu Val Glu His Tyr Lys 
    530                 535                 540                 


Lys Ala Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu Tyr Leu Val 
545                 550                 555                 560 


Arg Ala Leu Gln Gly Gly Ser Asp Gly Gln Asp Lys Gly Ser Asp Gly 
                565                 570                 575     


Gln Asp Lys Gly Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
            580                 585                 590         


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
        595                 600                 605             


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
    610                 615                 620                 


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
625                 630                 635                 640 


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala 
                645                 650                 655     


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
            660                 665                 670         


Leu Arg Ala Ala His Glu Leu Gly Trp 
        675                 680     


<210>  124
<211>  1941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6SS_scMHC (Construct containing 6 repeats and inserted 
       fusions of single chain MHC)

<400>  124
atggagacag acacactgct gctgtgggtg ctgctgctgt gggtgccagg ctccaccggc       60

aacctggtgc ctatggtggc aacagtggga tgcggagcct ctggaggagg aggcagcggc      120

ggaggaggct ccatccagag gaccccaaag atccaggtgt acagccgcca cccagcagag      180

aacggcaagt ccaacttcct gaattgttac gtgagcggct ttcacccaag cgacatcgag      240

gtggatctgc tgaagaatgg cgagcggatc gagaaggtgg agcactctga cctgagcttc      300

tccaaggatt ggagctttta cctgctgtac tataccgagt tcaccccaac agagaaggac      360

gagtatgcct gccgggtgaa tcacgtgaca ctgtctcagc ccaagatcgt gaagtgggac      420

agagatatgg gaggaggagg ctccggagga ggaggctctg gcggcggcgg cagcggaggc      480

ggcggctctg gcagccactc catgcggtac ttctttacct ctgtgagcag gcctggaagg      540

ggagagccac ggtttatcgc agtgggctat gtggacgata cacagttcgt gagatttgac      600

tccgatgcag catctcagag gatggagcca cgcgccccat ggatcgagca ggagggacca      660

gagtactggg acggagagac acggaaggtg aaggcccaca gccagaccca ccgggtggat      720

ctgggcacac tgagaggctg ctacaaccag agcgaggcag gctcccacac cgtgcagaga      780

atgtatggct gtgacgtggg cagcgattgg cggttcctga gaggctacca ccagtacgcc      840

tatgacggca aggattatat cgccctgaag gaggacctga ggtcctggac cgcagcagat      900

atggcagcac agaccacaaa gcacaagtgg gaggcagcac acgtggcaga gcagctgagg      960

gcctacctgg agggcacatg cgtggagtgg ctgcggagat atctggagaa tggcaaggag     1020

acactgcagc ggacagacgc ccctaagacc cacatgacac accacgccgt gtccgatcac     1080

gaggccaccc tgagatgttg ggccctgtct ttctacccag ccgagatcac cctgacatgg     1140

cagagggacg gcgaggatca gacccaggac acagagctgg tggagacacg gcccgcaggc     1200

gatggcacat ttcagaagtg ggcagcagtg gtggtgcctt ccggacagga gcagaggtat     1260

acctgtcacg tgcagcacga gggcctgccc aagcctctga cactgcgctg ggagcctggc     1320

ggcggcggat ccggaggagg aggctcctgc gaggccatca aggctgccgc cgagctgggc     1380

aaggcaggca tctctagcga ggagatcctg gagctgctga gggcagcaca cgagctgggc     1440

ctggacccag aagccatcaa ggctgccgcc gaactgggca aggccggcat ctcctctgaa     1500

gaaatcctgg agctgctgag agccgcccat gaactgggcc tggaccccga agccatcaag     1560

gctgccgccg agttaggcaa ggcaggcatc agctccgaag aaatcctgga gttactgaga     1620

gccgcccatg agctgggcct ggaccctgag gccatcaagg ctgccgccga gctaggcaag     1680

gccggcatct ctagcgaaga aatcctggag cttctgagag ccgcccacga attaggcctg     1740

gaccccgagg ccatcaaggc tgccgccgag cttggcaagg caggcatctc ctctgaagag     1800

atcctggagt tattaagagc cgcccacgaa cttggcctgg accccgagtg tatcaaggct     1860

gccgccgaat taggcaaggc cggcatcagc tccgaagaga tcctggagct tttacgggcc     1920

gcccacgagc tgggcctgta a                                               1941


<210>  125
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6SS_scMHC (Construct containing 6 repeats and inserted 
       fusions of single chain MHC)

<400>  125

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Leu Val Pro Met Val Ala Thr Val Gly Cys Gly 
            20                  25                  30          


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
    210                 215                 220                 


Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp 
225                 230                 235                 240 


Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His 
                245                 250                 255     


Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe 
            260                 265                 270         


Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
        275                 280                 285             


Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln 
    290                 295                 300                 


Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met 
            340                 345                 350         


Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
            420                 425                 430         


Leu Thr Leu Arg Trp Glu Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
    450                 455                 460                 


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
465                 470                 475                 480 


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
                485                 490                 495     


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
            500                 505                 510         


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
        515                 520                 525             


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
    530                 535                 540                 


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
545                 550                 555                 560 


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
                565                 570                 575     


Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
            580                 585                 590         


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
        595                 600                 605             


His Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu 
    610                 615                 620                 


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
625                 630                 635                 640 


Ala His Glu Leu Gly Leu 
                645     


<210>  126
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6_SS_mFAP (Construct containing 6 repeats and inserted 
       fusions of mFAP fluorescent protein domains)

<400>  126
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagctcc       60

atgggcctgg attgcgaggc gattaaggct gcggcggaac tgggtaaagc gggcatcagc      120

agcgaggaaa ttctggagct gctgcgtgcg gcgcatgagc tgggtctgga cccggaagcg      180

atcaaggctg cggcggagct gggcaaggcg ggcatcagca gcgaagaaat tctggaactg      240

ctgcgcgcgg cgcatgaact gggtctggac ccggaggcga tcaaagctgc ggcggagctg      300

ggtaaggctg gcatcagcag cgaagagatt ctggaattat tacgcgctgc tcatgagtta      360

ggtctggacc cggaagctat taaagctgcg gcggaactgg gcaaagcggg tggcggtagc      420

ggcggtggca gcagccgtgc ggcgcagctg ctgccgggca cctggcaagc gaccttcacc      480

aacgaagatg gtcagaccag ccagggccaa tggcactttc aaccgcgtag cccgtacacg      540

atggacatcg tggcgcaggg caccatcagc gatggccgtc cgatcgtggg ttacggcaag      600

gcgaccgtta aaaccccgga caccctggac atcgatatta cctatccgag cctgggtaac      660

attaaggcgc agggccaaat cacgatggac agcccgaccc aattcaagtg ggatgcgacc      720

accaaaggcg agaacgactt tcacggtcgt ctgaccggca ccctgcagcg tcaagaaggt      780

ggcggtagcg gcggtggcag cggtatcagc agcgaggaga ttctggagtt attacgcgct      840

gcccatgagt tgggtctgga cccggaagca attaaggctg cggcggagtt aggcaaagct      900

ggcatcagca gcgaggagat tctggaatta cttcgcgctg ctcatgagct tggtctggac      960

ccggaatgca tcaaggctgc ggcggaatta ggcaaggctg gcatcagcag cgaggaaatt     1020

ctggagttac tgcgtgcggc gcatgaactg ggctaa                               1056


<210>  127
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6_SS_mFAP (Construct containing 6 repeats and inserted 
       fusions of mFAP fluorescent protein domains)

<400>  127

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ser Met Gly Leu Asp Cys Glu Ala Ile Lys Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
        35                  40                  45              


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
    50                  55                  60                  


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
                85                  90                  95      


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
            100                 105                 110         


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
        115                 120                 125             


Ala Ala Ala Glu Leu Gly Lys Ala Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Ser Arg Ala Ala Gln Leu Leu Pro Gly Thr Trp Gln Ala Thr Phe Thr 
145                 150                 155                 160 


Asn Glu Asp Gly Gln Thr Ser Gln Gly Gln Trp His Phe Gln Pro Arg 
                165                 170                 175     


Ser Pro Tyr Thr Met Asp Ile Val Ala Gln Gly Thr Ile Ser Asp Gly 
            180                 185                 190         


Arg Pro Ile Val Gly Tyr Gly Lys Ala Thr Val Lys Thr Pro Asp Thr 
        195                 200                 205             


Leu Asp Ile Asp Ile Thr Tyr Pro Ser Leu Gly Asn Ile Lys Ala Gln 
    210                 215                 220                 


Gly Gln Ile Thr Met Asp Ser Pro Thr Gln Phe Lys Trp Asp Ala Thr 
225                 230                 235                 240 


Thr Lys Gly Glu Asn Asp Phe His Gly Arg Leu Thr Gly Thr Leu Gln 
                245                 250                 255     


Arg Gln Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ile Ser Ser Glu 
            260                 265                 270         


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
        275                 280                 285             


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
    290                 295                 300                 


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
305                 310                 315                 320 


Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
                325                 330                 335     


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            340                 345                 350     


<210>  128
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6SS_scMHC_mFAP (Construct containing 6 repeats and 
       inserted fusions of scMHC and mFAP fluorescent protein domains)

<400>  128
atggagaccg atacactgct gctgtgggtg ctgctgctgt gggtgcccgg cagcacaggc       60

tacatgctgg acctgcagcc tgagactgga ggaggaggat ccggaggagg aggctctggc      120

ggcggcggca gcatccagcg gaccccaaag atccaggtgt acagccggca cccagcagag      180

aacggcaaga gcaacttcct gaattgctac gtgagcggct ttcacccctc tgacatcgag      240

gtggatctgc tgaagaatgg cgagagaatc gagaaggtgg agcactccga cctgtctttc      300

agcaaggatt ggtcttttta cctgctgtac tatacagagt tcacccctac agagaaggac      360

gagtatgcct gtcgggtgaa ccacgtgacc ctgtcccagc caaagatcgt gaagtgggac      420

agagatatgg gaggaggagg cagcggcggc ggaggctccg gaggcggcgg ctctggagga      480

ggcggctccg gctctcacag catgaggtac ttctttacat ccgtgtctag gccaggaagg      540

ggagagcctc ggtttatcgc cgtgggctat gtggacgata cccagttcgt gagatttgac      600

agcgatgcag cctcccagag gatggagcca cgcgccccct ggatcgagca ggagggccct      660

gagtactggg atggcgagac caggaaggtg aaggcccaca gccagacaca cagggtggac      720

ctgggcaccc tgagaggagc ctacaaccag tctgaggcag gcagccacac cgtgcagagg      780

atgtatggct gcgacgtggg ctccgattgg cggttcctga gaggctacca ccagtacgcc      840

tatgacggca aggattatat cgccctgaag gaggacctgc ggagctggac agcagcagat      900

atggcagccc agaccacaaa gcacaagtgg gaggcagcac acgtggcaga gcagctgaga      960

gcctacctgg agggcacctg cgtggagtgg ctgcggagat acctggagaa tggcaaggag     1020

acactgcaga ggaccgatgc ccccaagacc cacatgacac accacgccgt gtctgaccac     1080

gaggccaccc tgaggtgttg ggcactgagc ttctaccctg ccgagatcac cctgacatgg     1140

cagagggacg gcgaggatca gacccaggat acagagctgg tggagacaag gccagcaggc     1200

gacggcacct ttcagaagtg ggcagcagtg gtggtgccct ccggacagga gcagaggtat     1260

acatgccacg tgcagcacga gggactgcca aagcctctga ccctgagatg ggagccagga     1320

ggaggaggca gcggaggagg aggctcctgt gaggccatca aggctgccgc cgagctgggc     1380

aaggcaggca tcagctccga ggagatcctg gagctgctga gggcagcaca cgagctgggc     1440

ctggaccccg aagccatcaa ggctgccgcc gaactgggca aggccggcat ctctagcgaa     1500

gaaatcctgg agctgctgag agccgcccat gaactgggcc tggaccccga ggccatcaag     1560

gctgccgccg agttaggcaa ggcaggcatc tcctctgaag agatcctgga gttattaaga     1620

gccgcccatg agttaggcct ggaccccgag gccatcaagg ctgccgccga gctaggcaag     1680

gccggcatca gctccgaaga aatcctggag ttactgagag ccgcccatga gctgggcctg     1740

gacccagagg ccatcaaggc tgccgccgag cttggcaagg caggcatctc tagcgaagag     1800

atcctggagc ttttaagagc cgcccacgaa ttaggcctgg accccgagtg tatcaaggct     1860

gccgccgagc tcggcaaggc cggcatctcc tctgaggaaa tcctggagtt gttaagggcc     1920

gcccacgagc tgggaggagg cagctcccgc gccgcccagc tgctgcccgg cacatggcag     1980

gccaccttca caaatgagga cggacagacc agccagggac agtggcactt tcagcctcgg     2040

tccccataca caatggacat cgtggcacag ggcaccatca gcgacggcag acctatcgtg     2100

ggctacggca aggccaccgt gaagacacct gacaccctgg acatcgacat cacctatcca     2160

tccctgggca acatcaaggc ccagggccag atcacaatgg actctccaac ccagttcaag     2220

tgggatgcca ccacaaaggg cgagaatgac tttcacggca ggctgaccgg cacactgcag     2280

aggcaggagt aa                                                         2292


<210>  129
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24_Sub6SS_scMHC_mFAP

<400>  129

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Tyr Met Leu Asp Leu Gln Pro Glu Thr Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
    210                 215                 220                 


Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp 
225                 230                 235                 240 


Leu Gly Thr Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His 
                245                 250                 255     


Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe 
            260                 265                 270         


Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
        275                 280                 285             


Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln 
    290                 295                 300                 


Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met 
            340                 345                 350         


Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
            420                 425                 430         


Leu Thr Leu Arg Trp Glu Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
    450                 455                 460                 


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
465                 470                 475                 480 


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
                485                 490                 495     


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
            500                 505                 510         


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
        515                 520                 525             


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
    530                 535                 540                 


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
545                 550                 555                 560 


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
                565                 570                 575     


Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
            580                 585                 590         


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
        595                 600                 605             


His Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu 
    610                 615                 620                 


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
625                 630                 635                 640 


Ala His Glu Leu Gly Gly Gly Ser Ser Arg Ala Ala Gln Leu Leu Pro 
                645                 650                 655     


Gly Thr Trp Gln Ala Thr Phe Thr Asn Glu Asp Gly Gln Thr Ser Gln 
            660                 665                 670         


Gly Gln Trp His Phe Gln Pro Arg Ser Pro Tyr Thr Met Asp Ile Val 
        675                 680                 685             


Ala Gln Gly Thr Ile Ser Asp Gly Arg Pro Ile Val Gly Tyr Gly Lys 
    690                 695                 700                 


Ala Thr Val Lys Thr Pro Asp Thr Leu Asp Ile Asp Ile Thr Tyr Pro 
705                 710                 715                 720 


Ser Leu Gly Asn Ile Lys Ala Gln Gly Gln Ile Thr Met Asp Ser Pro 
                725                 730                 735     


Thr Gln Phe Lys Trp Asp Ala Thr Thr Lys Gly Glu Asn Asp Phe His 
            740                 745                 750         


Gly Arg Leu Thr Gly Thr Leu Gln Arg Gln Glu 
        755                 760             


<210>  130
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aqualysin fused to cTRP24_Sub6SS

<400>  130

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu Ala Thr Gln Ser Pro Ala Pro 
            20                  25                  30          


Trp Gly Leu Asp Arg Ile Asp Gln Arg Asp Leu Pro Leu Ser Asn Ser 
        35                  40                  45              


Tyr Thr Tyr Thr Ala Thr Gly Arg Gly Val Asn Val Tyr Val Ile Asp 
    50                  55                  60                  


Thr Gly Ile Arg Thr Thr His Arg Glu Phe Gly Gly Arg Ala Arg Val 
65                  70                  75                  80  


Gly Tyr Asp Ala Leu Gly Gly Asn Gly Gln Asp Cys Asn Gly His Gly 
                85                  90                  95      


Thr His Val Ala Gly Thr Ile Gly Gly Val Thr Tyr Gly Val Ala Lys 
            100                 105                 110         


Ala Val Asn Leu Tyr Ala Val Arg Val Leu Asp Cys Asp Gly Ser Gly 
        115                 120                 125             


Ser Thr Ser Gly Val Ile Ala Gly Val Asp Trp Val Thr Arg Asn His 
    130                 135                 140                 


Arg Arg Pro Ala Val Ala Ser Met Ser Leu Gly Gly Gly Val Ser Thr 
145                 150                 155                 160 


Ala Leu Asp Asn Ala Val Lys Asn Ser Ile Ala Ala Gly Val Val Tyr 
                165                 170                 175     


Ala Val Ala Ala Gly Asn Asp Asn Ala Asn Ala Cys Asp Tyr Ser Pro 
            180                 185                 190         


Ala Arg Val Ala Glu Ala Leu Thr Val Gly Ala Thr Thr Ser Ser Asp 
        195                 200                 205             


Ala Arg Ala Ser Phe Ser Asn Tyr Gly Ser Cys Val Asp Leu Phe Ala 
    210                 215                 220                 


Pro Gly Ala Ser Ile Pro Ser Ala Trp Tyr Thr Ser Asp Thr Ala Thr 
225                 230                 235                 240 


Gln Thr Leu Asp Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Val 
                245                 250                 255     


Ala Ala Leu Tyr Leu Glu Gln Asn Pro Ser Ala Thr Pro Ala Ser Val 
            260                 265                 270         


Ala Ser Ala Ile Leu Asn Gly Ala Thr Thr Gly Arg Leu Ser Gly Ile 
        275                 280                 285             


Gly Ser Gly Ser Pro Asn Arg Leu Leu Tyr Ser Leu Leu Ser Ser Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Glu Ala Ile Lys 
305                 310                 315                 320 


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
                325                 330                 335     


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile 
            340                 345                 350         


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
        355                 360                 365             


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala 
    370                 375                 380                 


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
385                 390                 395                 400 


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
                405                 410                 415     


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
            420                 425                 430         


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
        435                 440                 445             


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
    450                 455                 460                 


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
465                 470                 475                 480 


Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
                485                 490                 495     


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
            500                 505                 510         


Gly Gly Ser His His His His His His 
        515                 520     


<210>  131
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clover fluorescent protein with N-terminal spytag

<400>  131
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagcgct       60

cacatcgtta tggtagatgc gtacaagccc accaaagggt ctagcggaag tagtggtagt      120

catatgatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag      180

ctggacggcg acgtaaacgg ccacaagttc agcgtccgcg gcgagggcga gggcgatgcc      240

accaacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg      300

cccaccctcg tgaccacctt cggctacggc gtggcctgct tcagccgcta ccccgaccac      360

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc      420

atctctttca aggacgacgg tacctacaag acccgcgccg aggtgaagtt cgagggcgac      480

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg      540

gggcacaagc tggagtacaa cttcaacagc cacaacgtct atatcacggc cgacaagcag      600

aagaacggca tcaaggctaa cttcaagatc cgccacaacg ttgaggacgg cagcgtgcag      660

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac      720

aaccactacc tgagccatca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac      780

atggtcctgc tggagttcgt gaccgccgcc tag                                   813


<210>  132
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clover fluorescent protein with N-terminal spytag

<400>  132

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
            20                  25                  30          


Gly Ser Ser Gly Ser Ser Gly Ser His Met Met Val Ser Lys Gly Glu 
        35                  40                  45              


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
    50                  55                  60                  


Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala 
65                  70                  75                  80  


Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
                85                  90                  95      


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Val Ala 
            100                 105                 110         


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
        115                 120                 125             


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys 
    130                 135                 140                 


Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
145                 150                 155                 160 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
                165                 170                 175     


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn 
            180                 185                 190         


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
        195                 200                 205             


Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His 
    210                 215                 220                 


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
225                 230                 235                 240 


Asn His Tyr Leu Ser His Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
                245                 250                 255     


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
            260                 265                 270 


<210>  133
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clover Fluorescent Protein

<400>  133

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Val Ala Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser His Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala 
225             


<210>  134
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mKate Fluorescent Protein

<400>  134

Met Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met His Met Lys 
1               5                   10                  15      


Leu Tyr Met Glu Gly Thr Val Asn Asn His His Phe Lys Cys Thr Ser 
            20                  25                  30          


Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys 
        35                  40                  45              


Ala Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr 
    50                  55                  60                  


Ser Phe Met Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile 
65                  70                  75                  80  


Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg 
                85                  90                  95      


Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr 
            100                 105                 110         


Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val 
        115                 120                 125             


Asn Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly 
145                 150                 155                 160 


Arg Ala Asp Met Ala Leu Lys Leu Val Gly Gly Gly His Leu Ile Cys 
                165                 170                 175     


Asn Leu Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys 
            180                 185                 190         


Met Pro Gly Val Tyr Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu 
        195                 200                 205             


Ala Asp Lys Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg 
    210                 215                 220                 


Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Arg 
225                 230                 235 


<210>  135
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SH2-SpyTag (SH2 domain with N-terminal spytag)

<400>  135
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagcgct       60

cacatcgtta tggtagatgc gtacaagccc accaaagggt ctagcggaag tagtggtagt      120

catatgtccg agtggtacta cgggaacgtg acgcggcacc aggccgagtg cgccctcaac      180

gagcggggcg tggagggcga cttcctcatt agggacagcg agtcctcgcc cagcgacttc      240

tccgtgtccc ttaaagcgtc agggaagaac aaacacttca aggtgcagct cgtggacaat      300

gtctactgca ttgggcagcg gcgcttccac accatggacg agctggtgga acactacaaa      360

aaggcgccca tcttcaccag cgagcacggg gagaagctct acctcgtcag ggccctgcag      420

tga                                                                    423


<210>  136
<211>  140
<212>  PRT
<213>  artificial Sequence

<220>
<223>  SH2-SpyTag (SH2 domain with N-terminal spytag)

<400>  136

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
            20                  25                  30          


Gly Ser Ser Gly Ser Ser Gly Ser His Met Ser Glu Trp Tyr Tyr Gly 
        35                  40                  45              


Asn Val Thr Arg His Gln Ala Glu Cys Ala Leu Asn Glu Arg Gly Val 
    50                  55                  60                  


Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Ser Asp Phe 
65                  70                  75                  80  


Ser Val Ser Leu Lys Ala Ser Gly Lys Asn Lys His Phe Lys Val Gln 
                85                  90                  95      


Leu Val Asp Asn Val Tyr Cys Ile Gly Gln Arg Arg Phe His Thr Met 
            100                 105                 110         


Asp Glu Leu Val Glu His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu 
        115                 120                 125             


His Gly Glu Lys Leu Tyr Leu Val Arg Ala Leu Gln 
    130                 135                 140 


<210>  137
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SH2 (Free SH2 domain)

<400>  137
atggctagca gccatcatca tcatcatcat agcagcggcc tggtgccgcg cggcagccat       60

atgtccgagt ggtactacgg gaacgtgacg cggcaccagg ccgagtgcgc cctcaacgag      120

cggggcgtgg agggcgactt cctcattagg gacagcgagt cctcgcccag cgacttctcc      180

gtgtccctta aagcgtcagg gaagaacaaa cacttcaagg tgcagctcgt ggacaatgtc      240

tactgcattg ggcagcggcg cttccacacc atggacgagc tggtggaaca ctacaaaaag      300

gcgcccatct tcaccagcga gcacggggag aagctctacc tcgtcagggc cctgcagtga      360


<210>  138
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH2 (Free SH2 domain)

<400>  138

Met Ala Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His 
            20                  25                  30          


Gln Ala Glu Cys Ala Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu 
        35                  40                  45              


Ile Arg Asp Ser Glu Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys 
    50                  55                  60                  


Ala Ser Gly Lys Asn Lys His Phe Lys Val Gln Leu Val Asp Asn Val 
65                  70                  75                  80  


Tyr Cys Ile Gly Gln Arg Arg Phe His Thr Met Asp Glu Leu Val Glu 
                85                  90                  95      


His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu 
            100                 105                 110         


Tyr Leu Val Arg Ala Leu Gln 
        115                 


<210>  139
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spytagged single chain Fv (scFv) targeting IHF-1

<400>  139

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Gly Ser Ser Ala His Ile Val Met Val Asp Ala 
            20                  25                  30          


Tyr Lys Pro Thr Lys Asp Ile Val Leu Thr Gln Ala Pro Gly Thr Leu 
        35                  40                  45              


Ser Leu Ser Pro Gly Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
    50                  55                  60                  


Arg Leu Gly Gly Thr Ser Leu Ala Trp Tyr Gln His Arg Ser Gly Gln 
65                  70                  75                  80  


Ala Pro Arg Leu Ile Leu Tyr Gly Thr Ser Asn Arg Ala Thr Asp Thr 
                85                  90                  95      


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Val Leu Thr 
            100                 105                 110         


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Gly Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Thr Leu Asp Ile 
    130                 135                 140                 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
                165                 170                 175     


Thr Leu Ser Leu Thr Cys Arg Val Ser Gly Asp Ser Asn Arg Pro Ser 
            180                 185                 190         


Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Ala Met Glu Trp Ile 
        195                 200                 205             


Gly Tyr Val Tyr Asp Ser Gly Val Thr Ile Tyr Asn Pro Ser Leu Lys 
    210                 215                 220                 


Gly Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Thr Arg Phe Ser Leu 
225                 230                 235                 240 


Lys Leu Thr Ser Val Ile Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Glu Arg Phe Asp Arg Thr Ser Tyr Lys Ser Trp Trp Gly Gln Gly 
            260                 265                 270         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser His His His His 
        275                 280                 285             


His His 
    290 


<210>  140
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv_IHF1_TRL1068-Toroidx6_SS_tetramer-His

<400>  140

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Arg Val Ser Gly Asp Ser 
        35                  40                  45              


Asn Arg Pro Ser Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Ala 
    50                  55                  60                  


Met Glu Trp Ile Gly Tyr Val Tyr Asp Ser Gly Val Thr Ile Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Gly Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Thr 
                85                  90                  95      


Arg Phe Ser Leu Lys Leu Thr Ser Val Ile Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Arg Phe Asp Arg Thr Ser Tyr Lys Ser Trp 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ala Pro Gly Thr Leu Ser Leu Ser Pro Gly Asp Arg Ala Thr Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Arg Leu Gly Gly Thr Ser Leu Ala Trp Tyr 
            180                 185                 190         


Gln His Arg Ser Gly Gln Ala Pro Arg Leu Ile Leu Tyr Gly Thr Ser 
        195                 200                 205             


Asn Arg Ala Thr Asp Thr Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Val Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Pro Pro Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Thr Leu Asp Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
        275                 280                 285             


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
    290                 295                 300                 


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
305                 310                 315                 320 


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
                325                 330                 335     


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
            340                 345                 350         


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
        355                 360                 365             


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
    370                 375                 380                 


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
385                 390                 395                 400 


Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
                405                 410                 415     


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
            420                 425                 430         


His Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu 
        435                 440                 445             


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
    450                 455                 460                 


Ala His Glu Leu Gly Leu Gly Gly Ser His His His His His His 
465                 470                 475                 


<210>  141
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC alpha chain

<400>  141

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  142
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  142

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro 
            20                  25                  30          


Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys 
        35                  40                  45              


Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  143
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  144
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  145
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  146
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huOKT3 variable heavy chain

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  147
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huOKT3 variable light chain

<400>  147

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of huOKT3

<400>  148

Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10  


<210>  149
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of huOKT3

<400>  149

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3  of huOKT3

<400>  150

Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr 
1               5                   10  


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of huOKT3

<400>  151

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of huOKT3

<400>  152

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of huOKT3

<400>  153

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  154
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv_CD3_hsOKT3-Toroidx6_SS_tetramer-His

<400>  154

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Gln Ile Thr Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
        275                 280                 285             


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
    290                 295                 300                 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
305                 310                 315                 320 


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
                325                 330                 335     


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
            340                 345                 350         


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
        355                 360                 365             


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
    370                 375                 380                 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
385                 390                 395                 400 


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
                405                 410                 415     


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
            420                 425                 430         


Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly 
        435                 440                 445             


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
    450                 455                 460                 


His Glu Leu Gly Leu Gly Gly Ser His His His His His His 
465                 470                 475             


<210>  155
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv_CD28_TGN1412-Toroidx6_SS_tetramer-His

<400>  155

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn 
        195                 200                 205             


Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
        275                 280                 285             


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
    290                 295                 300                 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
305                 310                 315                 320 


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
                325                 330                 335     


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
            340                 345                 350         


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
        355                 360                 365             


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
    370                 375                 380                 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
385                 390                 395                 400 


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
                405                 410                 415     


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
            420                 425                 430         


Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly 
        435                 440                 445             


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
    450                 455                 460                 


His Glu Leu Gly Leu Gly Gly Ser His His His His His His 
465                 470                 475             


<210>  156
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  156

Leu Pro His Asp 
1               


<210>  157
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  157

Asn Pro Asn Asp 
1               


<210>  158
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  158

Asp Pro Lys Asp 
1               


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  159

Gly Leu Glu Pro Asp 
1               5   


<210>  160
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  160

Gly Val Ser Leu Asp 
1               5   


<210>  161
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  161

Gly Val Leu Pro Asp 
1               5   


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  phosphotyrosyl-containing peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  phosphotyrosyl

<400>  162

Glu His Ile Tyr Asp Glu Val Ala Ala Asp 
1               5                   10  


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic cytomegalovirus peptide

<400>  163

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  164
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide derived from in-frame deletion of exons 2 to 
       7

<400>  164

Leu Glu Glu Lys Lys Gly Asn Tyr Trp Thr Asp His Cys 
1               5                   10              


<210>  165
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  165

Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys 
1               5                   10                  15      


Ser Glu 
        


<210>  166
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LL-37: antimicrobial peptide

<400>  166

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1037: antimicrobial peptide

<400>  167

Lys Arg Phe Arg Ile Arg Val Arg Val 
1               5                   


<210>  168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1018: antimicrobial peptide

<400>  168

Val Arg Leu Ile Val Ala Val Arg Ile Trp Arg Arg 
1               5                   10          


<210>  169
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Esculentin-1a (121): antimicrobial peptide

<400>  169

Gly Ile Phe Ser Lys Leu Ala Gly Lys Lys Ile Lys Asn Leu Leu Ile 
1               5                   10                  15      


Ser Gly Leu Lys Gly 
            20      


<210>  170
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nisin A: antimicrobial peptide

<400>  170

Met Ser Thr Lys Asp Phe Asn Leu Asp Leu Val Ser Val Ser Lys Lys 
1               5                   10                  15      


Asp Ser Gly Ala Ser Pro Arg 
            20              


<210>  171
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lacticin Q: antimicrobial peptide

<400>  171

Met Ala Gly Phe Leu Lys Val Val Gln Leu Leu Ala Lys Tyr Gly Ser 
1               5                   10                  15      


Lys Ala Val Gln Met Ala Trp Ala Asn Lys Gly Lys Ile Leu Asp Trp 
            20                  25                  30          


Leu Asn Ala Gly Gln Ala Ile Asp Lys Val Val Ser Lys Ile Lys Gln 
        35                  40                  45              


Ile Leu Gly Ile Lys 
    50              


<210>  172
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RN3 (5-17P22-36): antimicrobial peptide

<400>  172

Arg Pro Phe Thr Arg Ala Gln Trp Phe Ala Ile Gln His Ile Ser Pro 
1               5                   10                  15      


Arg Thr Ile Ala Met Arg Ala Ile Asn Asn Tyr Arg Trp Arg 
            20                  25                  30  


<210>  173
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S4 (116): antimicrobial peptide

<400>  173

Ala Leu Trp Lys Thr Leu Leu Lys Lys Val Leu Lys Ala Ala Ala Lys 
1               5                   10                  15      


<210>  174
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P1: antimicrobial peptide

<400>  174

Phe Val Asp Arg Asn Arg Ile Pro Arg Ser Asn Asn Gly Pro Lys Ile 
1               5                   10                  15      


Pro Ile Ile Ser Asn Pro 
            20          


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-K6L9: antimicrobial peptide

<400>  175

Leu Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Leu Leu 
1               5                   10                  15  


<210>  176
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Piscidin-3: antimicrobial peptide

<400>  176

Phe Ile His His Ile Phe Arg Gly Ile Val His Ala Gly Arg Ser Ile 
1               5                   10                  15      


Gly Arg Phe Leu Thr Gly 
            20          


<210>  177
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PI: antimicrobial peptide

<400>  177

Pro Ala Arg Lys Ala Arg Ala Ala Thr Ala Ala Thr Ala Ala Thr Ala 
1               5                   10                  15      


Ala Thr Ala Ala Thr 
            20      


<210>  178
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hepcidin 20: antimicrobial peptide

<400>  178

Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser His Cys Gly Met 
1               5                   10                  15      


Cys Cys Lys Thr 
            20  


<210>  179
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human beta-defensin 3 (hBD-3): antimicrobial peptide

<400>  179

Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr Cys Arg Val Arg Gly Gly 
1               5                   10                  15      


Arg Cys Ala Val Leu Ser Cys Leu Pro Lys Glu Glu Gln Ile Gly Lys 
            20                  25                  30          


Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg Arg Lys Lys 
        35                  40                  45  


<210>  180
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DJK-5: antimicrobial peptide

<400>  180

Val Gln Trp Arg Ala Ile Arg Val Arg Val Ile Arg 
1               5                   10          


<210>  181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible Gly-Ser linker

<400>  181

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible Gly-Ser linker

<400>  182

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible Gly-Ser linker

<400>  183

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible Gly-Ser linker

<400>  184

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible Gly-Ser linker

<400>  185

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  186
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible Gly-Ser linker

<400>  186

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  187
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  187

Gly Leu Asn Cys Glu Ala Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  188
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  188

Gly Leu Asp Cys Glu Ala Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  189
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  189

Gly Leu Asn Cys Glu Ala Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Thr Thr 
            


<210>  190
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  190

Gly Leu Asp Cys Glu Ala Glu Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  191
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  191

Gly Leu Asp Cys Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  192
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group VI

<400>  192

Gly Leu Asn Cys Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


<210>  193
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  193

Gly Leu Asp Cys Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Thr Thr 
            


<210>  194
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Group IX

<400>  194

Gly Leu Asp Cys Glu Ala Ile Lys Lys Ala Ala Glu Leu Gly Lys Ala 
1               5                   10                  15      


Gly Ile Ser 
            


<210>  195
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub6 cTRP construct containing 6 repeats, disulfide staples and 
       inserted fusions of a single chain trimer targeting 4-1BB

<400>  195

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
            20                  25                  30          


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
        35                  40                  45              


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
    50                  55                  60                  


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
65                  70                  75                  80  


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                85                  90                  95      


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
            100                 105                 110         


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
        115                 120                 125             


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
    130                 135                 140                 


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
145                 150                 155                 160 


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                165                 170                 175     


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
            180                 185                 190         


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly 
        195                 200                 205             


Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
    210                 215                 220                 


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
225                 230                 235                 240 


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
                245                 250                 255     


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
            260                 265                 270         


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
        275                 280                 285             


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
    290                 295                 300                 


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
305                 310                 315                 320 


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
                325                 330                 335     


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
            340                 345                 350         


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
        355                 360                 365             


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
    370                 375                 380                 


Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Arg Glu 
385                 390                 395                 400 


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                405                 410                 415     


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
            420                 425                 430         


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
        435                 440                 445             


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
    450                 455                 460                 


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
465                 470                 475                 480 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                485                 490                 495     


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
            500                 505                 510         


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
        515                 520                 525             


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
    530                 535                 540                 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
545                 550                 555                 560 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                565                 570                 575     


Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
        595                 600                 605             


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
    610                 615                 620                 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
625                 630                 635                 640 


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
                645                 650                 655     


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
            660                 665                 670         


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
        675                 680                 685             


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
    690                 695                 700                 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
705                 710                 715                 720 


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
                725                 730                 735     


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
            740                 745                 750         


Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly 
        755                 760                 765             


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
    770                 775                 780                 


His Glu Leu Gly Leu Gly Gly Ser His His His His His His 
785                 790                 795             


<210>  196
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub6 cTRP construct containing 6 repeats, disulfidestaples and 
       inserted fusions of a single chain trimer targeting OX40

<400>  196

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile 
            20                  25                  30          


Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr 
        35                  40                  45              


Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile 
    50                  55                  60                  


Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
65                  70                  75                  80  


Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu 
                85                  90                  95      


Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser 
            100                 105                 110         


Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr 
        115                 120                 125             


Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His 
    130                 135                 140                 


Gln Asn Pro Gly Glu Phe Cys Val Leu Gly Gly Gly Gly Ser Gln Val 
145                 150                 155                 160 


Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu 
                165                 170                 175     


Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu 
            180                 185                 190         


Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe 
        195                 200                 205             


Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser 
    210                 215                 220                 


Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
225                 230                 235                 240 


Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     


Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His 
            260                 265                 270         


Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
        275                 280                 285             


Cys Val Leu Gly Gly Gly Gly Ser Gln Val Ser His Arg Tyr Pro Arg 
    290                 295                 300                 


Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly 
305                 310                 315                 320 


Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn 
                325                 330                 335     


Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys 
            340                 345                 350         


Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp 
        355                 360                 365             


Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu 
    370                 375                 380                 


Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr 
385                 390                 395                 400 


Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                405                 410                 415     


Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Cys Glu Ala Ile Lys Ala Ala Ala Glu 
        435                 440                 445             


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
    450                 455                 460                 


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
465                 470                 475                 480 


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
                485                 490                 495     


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
            500                 505                 510         


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
        515                 520                 525             


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala 
    530                 535                 540                 


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
545                 550                 555                 560 


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys 
                565                 570                 575     


Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu 
            580                 585                 590         


Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Cys Ile 
        595                 600                 605             


Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile 
    610                 615                 620                 


Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Gly Gly Ser His 
625                 630                 635                 640 


His His His His His 
                645 


<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201

<400>  201
000

<210>  202

<400>  202
000

<210>  203

<400>  203
000

<210>  204

<400>  204
000

<210>  205
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of OKT3 antibody

<400>  205

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  206

<400>  206
000

<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of OKT3 antibody

<400>  207

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  208

<400>  208
000

<210>  209
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of OKT3 antibody

<400>  209

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  210

<400>  210
000

<210>  211
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  211

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  212
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 20G6-F3 antibody

<400>  212

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 20G6-F3 antibody w

<400>  213

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  214
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 20G6-F3 antibody

<400>  214

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 20G6-F3 antibody

<400>  215

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  216
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 20G6-F3 antibody

<400>  216

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  217
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4B4-D7 antibody

<400>  217

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  218

<400>  218
000

<210>  219
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4B4-D7 antibody

<400>  219

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4B4-D7 antibody

<400>  220

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  221
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4B4-D7 antibody

<400>  221

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  222
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4E7-C9 antibody

<400>  222

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  223

<400>  223
000

<210>  224

<400>  224
000

<210>  225
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4E7-C9 antibody

<400>  225

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  226
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4E7-C9 antibody

<400>  226

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  227
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 18F5-H10 antibody

<400>  227

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 18F5-H10 antibody

<400>  228

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  229
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 18F5-H10 antibody

<400>  229

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  230
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 18F5-H10 antibody

<400>  230

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  231
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 18F5-H10 antibody

<400>  231

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  232
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of TGN1412

<400>  232

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  233
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of TGN1412

<400>  233

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  234
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of TGN1412 antibody

<400>  234

His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
1               5                   10      


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of TGN1412 antibody

<400>  235

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of TGN1412 antibody

<400>  236

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  237
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of TGN1412 antibody

<400>  237

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  238
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of TGN1412 antibody

<400>  238

Ser Tyr Tyr Ile His 
1               5   


<210>  239
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of TGN1412 antibody

<400>  239

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys 
1               5                   10                  


<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of TGN1412 antibody

<400>  240

Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
1               5                   10      


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRL1

<400>  241

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  242
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRL2

<400>  242

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  243
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRL3

<400>  243

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  244
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRH1

<400>  244

Tyr Tyr Trp Ser 
1               


<210>  245
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRH3

<400>  245

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  246
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRL1

<400>  246

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRL2

<400>  247

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  248
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRL3

<400>  248

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  249
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRH1

<400>  249

Gly Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   10  


<210>  250
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRH2

<400>  250

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
1               5                   10                  


<210>  251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB CDRH3

<400>  251

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  252
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-cTRP 24x8-SH2 protein sequence

<400>  252

Met Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln 
1               5                   10                  15      


Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu 
            20                  25                  30          


Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met 
        35                  40                  45              


Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala 
    50                  55                  60                  


Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg 
65                  70                  75                  80  


Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu 
                85                  90                  95      


Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala 
            100                 105                 110         


Leu Arg Glu Gly Gly Gly Ser Asp Gly Gln Asp Lys Gly Ser Asp Gly 
        115                 120                 125             


Gln Asp Lys Gly Gly Ser Glu Trp Tyr Tyr Gly Asn Val Thr Arg His 
    130                 135                 140                 


Gln Ala Glu Cys Ala Leu Asn Glu Arg Gly Val Glu Gly Asp Phe Leu 
145                 150                 155                 160 


Ile Arg Asp Ser Glu Ser Ser Pro Ser Asp Phe Ser Val Ser Leu Lys 
                165                 170                 175     


Ala Ser Gly Lys Asn Lys His Phe Lys Val Gln Leu Val Asp Asn Val 
            180                 185                 190         


Tyr Cys Ile Gly Gln Arg Arg Phe His Thr Met Asp Glu Leu Val Glu 
        195                 200                 205             


His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu His Gly Glu Lys Leu 
    210                 215                 220                 


Tyr Leu Val Arg Ala Leu Gln Gly Gly Ser Asp Gly Gln Asp Lys Gly 
225                 230                 235                 240 


Ser Asp Gly Gln Asp Lys Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu 
                245                 250                 255     


Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu 
            260                 265                 270         


Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu 
        275                 280                 285             


Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly 
    290                 295                 300                 


Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu 
305                 310                 315                 320 


Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu 
                325                 330                 335     


Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg 
            340                 345                 350         


Val Val Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg 
        355                 360                 365             


Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala 
    370                 375                 380                 


Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu 
385                 390                 395                 400 


Glu Glu Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg 
                405                 410                 415     


Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln 
            420                 425                 430         


Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu 
        435                 440                 445             


Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met 
    450                 455                 460                 


Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly Gly Gly Ser Asp Gly 
465                 470                 475                 480 


Gln Asp Lys Gly Ser Asp Gly Gln Asp Lys Gly Gly Ser Glu Trp Tyr 
                485                 490                 495     


Tyr Gly Asn Val Thr Arg His Gln Ala Glu Cys Ala Leu Asn Glu Arg 
            500                 505                 510         


Gly Val Glu Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Ser 
        515                 520                 525             


Asp Phe Ser Val Ser Leu Lys Ala Ser Gly Lys Asn Lys His Phe Lys 
    530                 535                 540                 


Val Gln Leu Val Asp Asn Val Tyr Cys Ile Gly Gln Arg Arg Phe His 
545                 550                 555                 560 


Thr Met Asp Glu Leu Val Glu His Tyr Lys Lys Ala Pro Ile Phe Thr 
                565                 570                 575     


Ser Glu His Gly Glu Lys Leu Tyr Leu Val Arg Ala Leu Gln Gly Gly 
            580                 585                 590         


Ser Asp Gly Gln Asp Lys Gly Ser Asp Gly Gln Asp Lys Gly Asn Ser 
        595                 600                 605             


Glu Leu Ala Ala Arg Ile Leu Ile Ile Leu Phe Gln Gln Leu Val Glu 
    610                 615                 620                 


Leu Ala Arg Leu Ala Ile Glu Ser Gly Asp Glu Glu Leu Leu Arg Arg 
625                 630                 635                 640 


Val Ser Glu Trp Leu Glu Glu Val Ile Lys Asp Met Arg Arg Val Val 
                645                 650                 655     


Glu Gln Ala Leu Arg Glu Gly Asn Ser Glu Leu Ala Ala Arg Ile Leu 
            660                 665                 670         


Ile Ile Leu Phe Gln Gln Leu Val Glu Leu Ala Arg Leu Ala Ile Glu 
        675                 680                 685             


Ser Gly Asp Glu Glu Leu Leu Arg Arg Val Ser Glu Trp Leu Glu Glu 
    690                 695                 700                 


Val Ile Lys Asp Met Arg Arg Val Val Glu Gln Ala Leu Arg Glu Gly 
705                 710                 715                 720 


<210>  253
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24 subunit, FLAG tag, and TEV-His-Avi tag

<400>  253

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu Gly Gly Gly Ser Cys Glu Ala 
            20                  25                  30          


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        35                  40                  45              


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    50                  55                  60                  


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
65                  70                  75                  80  


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                85                  90                  95      


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            100                 105                 110         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        115                 120                 125             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    130                 135                 140                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
145                 150                 155                 160 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                165                 170                 175     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            180                 185                 190         


Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        195                 200                 205             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    210                 215                 220                 


Gly Leu Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser His His 
225                 230                 235                 240 


His His His His Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
                245                 250                 255     


Ile Glu Trp His Glu 
            260     


<210>  254
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP24 subunit, FLAG tag, and TEV-His-Avi tag

<400>  254

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu Gly Gly Gly Ser Cys Glu Ala 
            20                  25                  30          


Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu 
        35                  40                  45              


Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu 
    50                  55                  60                  


Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu 
65                  70                  75                  80  


Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro 
                85                  90                  95      


Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser 
            100                 105                 110         


Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu Asp 
        115                 120                 125             


Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
    130                 135                 140                 


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
145                 150                 155                 160 


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
                165                 170                 175     


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
            180                 185                 190         


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
        195                 200                 205             


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
    210                 215                 220                 


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
225                 230                 235                 240 


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
                245                 250                 255     


Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys 
            260                 265                 270         


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
        275                 280                 285             


Glu Leu Gly Leu Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser 
    290                 295                 300                 


His His His His His His Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala 
305                 310                 315                 320 


Gln Lys Ile Glu Trp His Glu 
                325         


