                         SEQUENCE LISTING

<110>  NAPIGEN, INC.
 
<120>  ORGANELLE GENOME MODIFICATION

<130>  51090-703.601

<150>  US 62/899,495
<151>  2019-09-12

<150>  US 62/870,441
<151>  2019-07-03

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  1334
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAD2 protein

<400>  2

Met Ser Ser Leu Thr Lys Phe Thr Asn Lys Tyr Ser Lys Gln Leu Thr 
1               5                   10                  15      


Ile Lys Asn Glu Leu Ile Pro Val Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Glu Asn Gly Leu Ile Asp Gly Asp Glu Gln Leu Asn Glu Asn Tyr Gln 
        35                  40                  45              


Lys Ala Lys Ile Ile Val Asp Asp Phe Leu Arg Asp Phe Ile Asn Lys 
    50                  55                  60                  


Ala Leu Asn Asn Thr Gln Ile Gly Asn Trp Arg Glu Leu Ala Asp Ala 
65                  70                  75                  80  


Leu Asn Lys Glu Asp Glu Asp Asn Ile Glu Lys Leu Gln Asp Lys Ile 
                85                  90                  95      


Arg Gly Ile Ile Val Ser Lys Phe Glu Thr Phe Asp Leu Phe Ser Ser 
            100                 105                 110         


Tyr Ser Ile Lys Lys Asp Glu Lys Ile Ile Asp Asp Asp Asn Asp Val 
        115                 120                 125             


Glu Glu Glu Glu Leu Asp Leu Gly Lys Lys Thr Ser Ser Phe Lys Tyr 
    130                 135                 140                 


Ile Phe Lys Lys Asn Leu Phe Lys Leu Val Leu Pro Ser Tyr Leu Lys 
145                 150                 155                 160 


Thr Thr Asn Gln Asp Lys Leu Lys Ile Ile Ser Ser Phe Asp Asn Phe 
                165                 170                 175     


Ser Thr Tyr Phe Arg Gly Phe Phe Glu Asn Arg Lys Asn Ile Phe Thr 
            180                 185                 190         


Lys Lys Pro Ile Ser Thr Ser Ile Ala Tyr Arg Ile Val His Asp Asn 
        195                 200                 205             


Phe Pro Lys Phe Leu Asp Asn Ile Arg Cys Phe Asn Val Trp Gln Thr 
    210                 215                 220                 


Glu Cys Pro Gln Leu Ile Val Lys Ala Asp Asn Tyr Leu Lys Ser Lys 
225                 230                 235                 240 


Asn Val Ile Ala Lys Asp Lys Ser Leu Ala Asn Tyr Phe Thr Val Gly 
                245                 250                 255     


Ala Tyr Asp Tyr Phe Leu Ser Gln Asn Gly Ile Asp Phe Tyr Asn Asn 
            260                 265                 270         


Ile Ile Gly Gly Leu Pro Ala Phe Ala Gly His Glu Lys Ile Gln Gly 
        275                 280                 285             


Leu Asn Glu Phe Ile Asn Gln Glu Cys Gln Lys Asp Ser Glu Leu Lys 
    290                 295                 300                 


Ser Lys Leu Lys Asn Arg His Ala Phe Lys Met Ala Val Leu Phe Lys 
305                 310                 315                 320 


Gln Ile Leu Ser Asp Arg Glu Lys Ser Phe Val Ile Asp Glu Phe Glu 
                325                 330                 335     


Ser Asp Ala Gln Val Ile Asp Ala Val Lys Asn Phe Tyr Ala Glu Gln 
            340                 345                 350         


Cys Lys Asp Asn Asn Val Ile Phe Asn Leu Leu Asn Leu Ile Lys Asn 
        355                 360                 365             


Ile Ala Phe Leu Ser Asp Asp Glu Leu Asp Gly Ile Phe Ile Glu Gly 
    370                 375                 380                 


Lys Tyr Leu Ser Ser Val Ser Gln Lys Leu Tyr Ser Asp Trp Ser Lys 
385                 390                 395                 400 


Leu Arg Asn Asp Ile Glu Asp Ser Ala Asn Ser Lys Gln Gly Asn Lys 
                405                 410                 415     


Glu Leu Ala Lys Lys Ile Lys Thr Asn Lys Gly Asp Val Glu Lys Ala 
            420                 425                 430         


Ile Ser Lys Tyr Glu Phe Ser Leu Ser Glu Leu Asn Ser Ile Val His 
        435                 440                 445             


Asp Asn Thr Lys Phe Ser Asp Leu Leu Ser Cys Thr Leu His Lys Val 
    450                 455                 460                 


Ala Ser Glu Lys Leu Val Lys Val Asn Glu Gly Asp Trp Pro Lys His 
465                 470                 475                 480 


Leu Lys Asn Asn Glu Glu Lys Gln Lys Ile Lys Glu Pro Leu Asp Ala 
                485                 490                 495     


Leu Leu Glu Ile Tyr Asn Thr Leu Leu Ile Phe Asn Cys Lys Ser Phe 
            500                 505                 510         


Asn Lys Asn Gly Asn Phe Tyr Val Asp Tyr Asp Arg Cys Ile Asn Glu 
        515                 520                 525             


Leu Ser Ser Val Val Tyr Leu Tyr Asn Lys Thr Arg Asn Tyr Cys Thr 
    530                 535                 540                 


Lys Lys Pro Tyr Asn Thr Asp Lys Phe Lys Leu Asn Phe Asn Ser Pro 
545                 550                 555                 560 


Gln Leu Gly Glu Gly Phe Ser Lys Ser Lys Glu Asn Asp Cys Leu Thr 
                565                 570                 575     


Leu Leu Phe Lys Lys Asp Asp Asn Tyr Tyr Val Gly Ile Ile Arg Lys 
            580                 585                 590         


Gly Ala Lys Ile Asn Phe Asp Asp Thr Gln Ala Ile Ala Asp Asn Thr 
        595                 600                 605             


Asp Asn Cys Ile Phe Lys Met Asn Tyr Phe Leu Leu Lys Asp Ala Lys 
    610                 615                 620                 


Lys Phe Ile Pro Lys Cys Ser Ile Gln Leu Lys Glu Val Lys Ala His 
625                 630                 635                 640 


Phe Lys Lys Ser Glu Asp Asp Tyr Ile Leu Ser Asp Lys Glu Lys Phe 
                645                 650                 655     


Ala Ser Pro Leu Val Ile Lys Lys Ser Thr Phe Leu Leu Ala Thr Ala 
            660                 665                 670         


His Val Lys Gly Lys Lys Gly Asn Ile Lys Lys Phe Gln Lys Glu Tyr 
        675                 680                 685             


Ser Lys Glu Asn Pro Thr Glu Tyr Arg Asn Ser Leu Asn Glu Trp Ile 
    690                 695                 700                 


Ala Phe Cys Lys Glu Phe Leu Lys Thr Tyr Lys Ala Ala Thr Ile Phe 
705                 710                 715                 720 


Asp Ile Thr Thr Leu Lys Lys Ala Glu Glu Tyr Ala Asp Ile Val Glu 
                725                 730                 735     


Phe Tyr Lys Asp Val Asp Asn Leu Cys Tyr Lys Leu Glu Phe Cys Pro 
            740                 745                 750         


Ile Lys Thr Ser Phe Ile Glu Asn Leu Ile Asp Asn Gly Asp Leu Tyr 
        755                 760                 765             


Leu Phe Arg Ile Asn Asn Lys Asp Phe Ser Ser Lys Ser Thr Gly Thr 
    770                 775                 780                 


Lys Asn Leu His Thr Leu Tyr Leu Gln Ala Ile Phe Asp Glu Arg Asn 
785                 790                 795                 800 


Leu Asn Asn Pro Thr Ile Met Leu Asn Gly Gly Ala Glu Leu Phe Tyr 
                805                 810                 815     


Arg Lys Glu Ser Ile Glu Gln Lys Asn Arg Ile Thr His Lys Ala Gly 
            820                 825                 830         


Ser Ile Leu Val Asn Lys Val Cys Lys Asp Gly Thr Ser Leu Asp Asp 
        835                 840                 845             


Lys Ile Arg Asn Glu Ile Tyr Gln Tyr Glu Asn Lys Phe Ile Asp Thr 
    850                 855                 860                 


Leu Ser Asp Glu Ala Lys Lys Val Leu Pro Asn Val Ile Lys Lys Glu 
865                 870                 875                 880 


Ala Thr His Asp Ile Thr Lys Asp Lys Arg Phe Thr Ser Asp Lys Phe 
                885                 890                 895     


Phe Phe His Cys Pro Leu Thr Ile Asn Tyr Lys Glu Gly Asp Thr Lys 
            900                 905                 910         


Gln Phe Asn Asn Glu Val Leu Ser Phe Leu Arg Gly Asn Pro Asp Ile 
        915                 920                 925             


Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Val Thr 
    930                 935                 940                 


Val Ile Asn Gln Lys Gly Glu Ile Leu Asp Ser Val Ser Phe Asn Thr 
945                 950                 955                 960 


Val Thr Asn Lys Ser Ser Lys Ile Glu Gln Thr Val Asp Tyr Glu Glu 
                965                 970                 975     


Lys Leu Ala Val Arg Glu Lys Glu Arg Ile Glu Ala Lys Arg Ser Trp 
            980                 985                 990         


Asp Ser Ile Ser Lys Ile Ala Thr  Leu Lys Glu Gly Tyr  Leu Ser Ala 
        995                 1000                 1005             


Ile Val  His Glu Ile Cys Leu  Leu Met Ile Lys His  Asn Ala Ile 
    1010                 1015                 1020             


Val Val  Leu Glu Asn Leu Asn  Ala Gly Phe Lys Arg  Ile Arg Gly 
    1025                 1030                 1035             


Gly Leu  Ser Glu Lys Ser Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1040                 1045                 1050             


Ile Asn  Lys Leu Asn Tyr Phe  Val Ser Lys Lys Glu  Ser Asp Trp 
    1055                 1060                 1065             


Asn Lys  Pro Ser Gly Leu Leu  Asn Gly Leu Gln Leu  Ser Asp Gln 
    1070                 1075                 1080             


Phe Glu  Ser Phe Glu Lys Leu  Gly Ile Gln Ser Gly  Phe Ile Phe 
    1085                 1090                 1095             


Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1100                 1105                 1110             


Phe Ala  Asn Val Leu Asn Leu  Ser Lys Val Arg Asn  Val Asp Ala 
    1115                 1120                 1125             


Ile Lys  Ser Phe Phe Ser Asn  Phe Asn Glu Ile Ser  Tyr Ser Lys 
    1130                 1135                 1140             


Lys Glu  Ala Leu Phe Lys Phe  Ser Phe Asp Leu Asp  Ser Leu Ser 
    1145                 1150                 1155             


Lys Lys  Gly Phe Ser Ser Phe  Val Lys Phe Ser Lys  Ser Lys Trp 
    1160                 1165                 1170             


Asn Val  Tyr Thr Phe Gly Glu  Arg Ile Ile Lys Pro  Lys Asn Lys 
    1175                 1180                 1185             


Gln Gly  Tyr Arg Glu Asp Lys  Arg Ile Asn Leu Thr  Phe Glu Met 
    1190                 1195                 1200             


Lys Lys  Leu Leu Asn Glu Tyr  Lys Val Ser Phe Asp  Leu Glu Asn 
    1205                 1210                 1215             


Asn Leu  Ile Pro Asn Leu Thr  Ser Ala Asn Leu Lys  Asp Thr Phe 
    1220                 1225                 1230             


Trp Lys  Glu Leu Phe Phe Ile  Phe Lys Thr Thr Leu  Gln Leu Arg 
    1235                 1240                 1245             


Asn Ser  Val Thr Asn Gly Lys  Glu Asp Val Leu Ile  Ser Pro Val 
    1250                 1255                 1260             


Lys Asn  Ala Lys Gly Glu Phe  Phe Val Ser Gly Thr  His Asn Lys 
    1265                 1270                 1275             


Thr Leu  Pro Gln Asp Cys Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1280                 1285                 1290             


Leu Lys  Gly Leu Met Ile Leu  Glu Arg Asn Asn Leu  Val Arg Glu 
    1295                 1300                 1305             


Glu Lys  Asp Thr Lys Lys Ile  Met Ala Ile Ser Asn  Val Asp Trp 
    1310                 1315                 1320             


Phe Glu  Tyr Val Gln Lys Arg  Arg Gly Val Leu 
    1325                 1330                 


<210>  3
<211>  1263
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAD 7 protein

<400>  3

Met Asn Asn Gly Thr Asn Asn Phe Gln Asn Phe Ile Gly Ile Ser Ser 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Thr Thr Gln 
            20                  25                  30          


Gln Phe Ile Val Lys Asn Gly Ile Ile Lys Glu Asp Glu Leu Arg Gly 
        35                  40                  45              


Glu Asn Arg Gln Ile Leu Lys Asp Ile Met Asp Asp Tyr Tyr Arg Gly 
    50                  55                  60                  


Phe Ile Ser Glu Thr Leu Ser Ser Ile Asp Asp Ile Asp Trp Thr Ser 
65                  70                  75                  80  


Leu Phe Glu Lys Met Glu Ile Gln Leu Lys Asn Gly Asp Asn Lys Asp 
                85                  90                  95      


Thr Leu Ile Lys Glu Gln Thr Glu Tyr Arg Lys Ala Ile His Lys Lys 
            100                 105                 110         


Phe Ala Asn Asp Asp Arg Phe Lys Asn Met Phe Ser Ala Lys Leu Ile 
        115                 120                 125             


Ser Asp Ile Leu Pro Glu Phe Val Ile His Asn Asn Asn Tyr Ser Ala 
    130                 135                 140                 


Ser Glu Lys Glu Glu Lys Thr Gln Val Ile Lys Leu Phe Ser Arg Phe 
145                 150                 155                 160 


Ala Thr Ser Phe Lys Asp Tyr Phe Lys Asn Arg Ala Asn Cys Phe Ser 
                165                 170                 175     


Ala Asp Asp Ile Ser Ser Ser Ser Cys His Arg Ile Val Asn Asp Asn 
            180                 185                 190         


Ala Glu Ile Phe Phe Ser Asn Ala Leu Val Tyr Arg Arg Ile Val Lys 
        195                 200                 205             


Ser Leu Ser Asn Asp Asp Ile Asn Lys Ile Ser Gly Asp Met Lys Asp 
    210                 215                 220                 


Ser Leu Lys Glu Met Ser Leu Glu Glu Ile Tyr Ser Tyr Glu Lys Tyr 
225                 230                 235                 240 


Gly Glu Phe Ile Thr Gln Glu Gly Ile Ser Phe Tyr Asn Asp Ile Cys 
                245                 250                 255     


Gly Lys Val Asn Ser Phe Met Asn Leu Tyr Cys Gln Lys Asn Lys Glu 
            260                 265                 270         


Asn Lys Asn Leu Tyr Lys Leu Gln Lys Leu His Lys Gln Ile Leu Cys 
        275                 280                 285             


Ile Ala Asp Thr Ser Tyr Glu Val Pro Tyr Lys Phe Glu Ser Asp Glu 
    290                 295                 300                 


Glu Val Tyr Gln Ser Val Asn Gly Phe Leu Asp Asn Ile Ser Ser Lys 
305                 310                 315                 320 


His Ile Val Glu Arg Leu Arg Lys Ile Gly Asp Asn Tyr Asn Gly Tyr 
                325                 330                 335     


Asn Leu Asp Lys Ile Tyr Ile Val Ser Lys Phe Tyr Glu Ser Val Ser 
            340                 345                 350         


Gln Lys Thr Tyr Arg Asp Trp Glu Thr Ile Asn Thr Ala Leu Glu Ile 
        355                 360                 365             


His Tyr Asn Asn Ile Leu Pro Gly Asn Gly Lys Ser Lys Ala Asp Lys 
    370                 375                 380                 


Val Lys Lys Ala Val Lys Asn Asp Leu Gln Lys Ser Ile Thr Glu Ile 
385                 390                 395                 400 


Asn Glu Leu Val Ser Asn Tyr Lys Leu Cys Ser Asp Asp Asn Ile Lys 
                405                 410                 415     


Ala Glu Thr Tyr Ile His Glu Ile Ser His Ile Leu Asn Asn Phe Glu 
            420                 425                 430         


Ala Gln Glu Leu Lys Tyr Asn Pro Glu Ile His Leu Val Glu Ser Glu 
        435                 440                 445             


Leu Lys Ala Ser Glu Leu Lys Asn Val Leu Asp Val Ile Met Asn Ala 
    450                 455                 460                 


Phe His Trp Cys Ser Val Phe Met Thr Glu Glu Leu Val Asp Lys Asp 
465                 470                 475                 480 


Asn Asn Phe Tyr Ala Glu Leu Glu Glu Ile Tyr Asp Glu Ile Tyr Pro 
                485                 490                 495     


Val Ile Ser Leu Tyr Asn Leu Val Arg Asn Tyr Val Thr Gln Lys Pro 
            500                 505                 510         


Tyr Ser Thr Lys Lys Ile Lys Leu Asn Phe Gly Ile Pro Thr Leu Ala 
        515                 520                 525             


Asp Gly Trp Ser Lys Ser Lys Glu Tyr Ser Asn Asn Ala Ile Ile Leu 
    530                 535                 540                 


Met Arg Asp Asn Leu Tyr Tyr Leu Gly Ile Phe Asn Ala Lys Asn Lys 
545                 550                 555                 560 


Pro Asp Lys Lys Ile Ile Glu Gly Asn Thr Ser Glu Asn Lys Gly Asp 
                565                 570                 575     


Tyr Lys Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Asn Lys Met Ile 
            580                 585                 590         


Pro Lys Val Phe Leu Ser Ser Lys Thr Gly Val Glu Thr Tyr Lys Pro 
        595                 600                 605             


Ser Ala Tyr Ile Leu Glu Gly Tyr Lys Gln Asn Lys His Ile Lys Ser 
    610                 615                 620                 


Ser Lys Asp Phe Asp Ile Thr Phe Cys His Asp Leu Ile Asp Tyr Phe 
625                 630                 635                 640 


Lys Asn Cys Ile Ala Ile His Pro Glu Trp Lys Asn Phe Gly Phe Asp 
                645                 650                 655     


Phe Ser Asp Thr Ser Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Leu Gln Gly Tyr Lys Ile Asp Trp Thr Tyr Ile Ser Glu Lys 
        675                 680                 685             


Asp Ile Asp Leu Leu Gln Glu Lys Gly Gln Leu Tyr Leu Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Lys Lys Ser Thr Gly Asn Asp Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile 
                725                 730                 735     


Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg Lys Ser Ser 
            740                 745                 750         


Ile Lys Asn Pro Ile Ile His Lys Lys Gly Ser Ile Leu Val Asn Arg 
        755                 760                 765             


Thr Tyr Glu Ala Glu Glu Lys Asp Gln Phe Gly Asn Ile Gln Ile Val 
    770                 775                 780                 


Arg Lys Asn Ile Pro Glu Asn Ile Tyr Gln Glu Leu Tyr Lys Tyr Phe 
785                 790                 795                 800 


Asn Asp Lys Ser Asp Lys Glu Leu Ser Asp Glu Ala Ala Lys Leu Lys 
                805                 810                 815     


Asn Val Val Gly His His Glu Ala Ala Thr Asn Ile Val Lys Asp Tyr 
            820                 825                 830         


Arg Tyr Thr Tyr Asp Lys Tyr Phe Leu His Met Pro Ile Thr Ile Asn 
        835                 840                 845             


Phe Lys Ala Asn Lys Thr Gly Phe Ile Asn Asp Arg Ile Leu Gln Tyr 
    850                 855                 860                 


Ile Ala Lys Glu Lys Asp Leu His Val Ile Gly Ile Asp Arg Gly Glu 
865                 870                 875                 880 


Arg Asn Leu Ile Tyr Val Ser Val Ile Asp Thr Cys Gly Asn Ile Val 
                885                 890                 895     


Glu Gln Lys Ser Phe Asn Ile Val Asn Gly Tyr Asp Tyr Gln Ile Lys 
            900                 905                 910         


Leu Lys Gln Gln Glu Gly Ala Arg Gln Ile Ala Arg Lys Glu Trp Lys 
        915                 920                 925             


Glu Ile Gly Lys Ile Lys Glu Ile Lys Glu Gly Tyr Leu Ser Leu Val 
    930                 935                 940                 


Ile His Glu Ile Ser Lys Met Val Ile Lys Tyr Asn Ala Ile Ile Ala 
945                 950                 955                 960 


Met Glu Asp Leu Ser Tyr Gly Phe Lys Lys Gly Arg Phe Lys Val Glu 
                965                 970                 975     


Arg Gln Val Tyr Gln Lys Phe Glu Thr Met Leu Ile Asn Lys Leu Asn 
            980                 985                 990         


Tyr Leu Val Phe Lys Asp Ile Ser  Ile Thr Glu Asn Gly  Gly Leu Leu 
        995                 1000                 1005             


Lys Gly  Tyr Gln Leu Thr Tyr  Ile Pro Asp Lys Leu  Lys Asn Val 
    1010                 1015                 1020             


Gly His  Gln Cys Gly Cys Ile  Phe Tyr Val Pro Ala  Ala Tyr Thr 
    1025                 1030                 1035             


Ser Lys  Ile Asp Pro Thr Thr  Gly Phe Val Asn Ile  Phe Lys Phe 
    1040                 1045                 1050             


Lys Asp  Leu Thr Val Asp Ala  Lys Arg Glu Phe Ile  Lys Lys Phe 
    1055                 1060                 1065             


Asp Ser  Ile Arg Tyr Asp Ser  Glu Lys Asn Leu Phe  Cys Phe Thr 
    1070                 1075                 1080             


Phe Asp  Tyr Asn Asn Phe Ile  Thr Gln Asn Thr Val  Met Ser Lys 
    1085                 1090                 1095             


Ser Ser  Trp Ser Val Tyr Thr  Tyr Gly Val Arg Ile  Lys Arg Arg 
    1100                 1105                 1110             


Phe Val  Asn Gly Arg Phe Ser  Asn Glu Ser Asp Thr  Ile Asp Ile 
    1115                 1120                 1125             


Thr Lys  Asp Met Glu Lys Thr  Leu Glu Met Thr Asp  Ile Asn Trp 
    1130                 1135                 1140             


Arg Asp  Gly His Asp Leu Arg  Gln Asp Ile Ile Asp  Tyr Glu Ile 
    1145                 1150                 1155             


Val Gln  His Ile Phe Glu Ile  Phe Arg Leu Thr Val  Gln Met Arg 
    1160                 1165                 1170             


Asn Ser  Leu Ser Glu Leu Glu  Asp Arg Asp Tyr Asp  Arg Leu Ile 
    1175                 1180                 1185             


Ser Pro  Val Leu Asn Glu Asn  Asn Ile Phe Tyr Asp  Ser Ala Lys 
    1190                 1195                 1200             


Ala Gly  Asp Ala Leu Pro Lys  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1205                 1210                 1215             


Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Ile Lys Gln  Ile Thr Glu 
    1220                 1225                 1230             


Asn Trp  Lys Glu Asp Gly Lys  Phe Ser Arg Asp Lys  Leu Lys Ile 
    1235                 1240                 1245             


Ser Asn  Lys Asp Trp Phe Asp  Phe Ile Gln Asn Lys  Arg Tyr Leu 
    1250                 1255                 1260             


<210>  4
<211>  16
<212>  PRT
<213>  Drosophila melanogaster

<400>  4

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  5
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Quencher peptide

<400>  5

Asp Glu Val Asp Phe Gln Gly Pro Cys Asn Asp Ser Ser Asp Pro Leu 
1               5                   10                  15      


Val Val Ala Ala Ser Ile Ile Gly Ile Leu His Leu Ile Leu Trp Ile 
            20                  25                  30          


Leu Asp Arg Leu 
        35      


<210>  6
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Caspase Site

<400>  6

Asp Glu Val Asp 
1               


<210>  7
<211>  27
<212>  RNA
<213>  Triticum aestivum

<400>  7
acuuuugaca guuauacgau uccagaa                                           27


<210>  8
<211>  27
<212>  RNA
<213>  Triticum aestivum

<400>  8
ugggcuguac cuuccucagg ugucaaa                                           27


<210>  9
<211>  27
<212>  RNA
<213>  Triticum aestivum

<400>  9
gcuguaccug gucguucaaa ucuuacc                                           27


<210>  10
<211>  4163
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10
aaaaaagaat ggttctacca agactatata cagctacaag tcgtgctgct ctgtcgaccg       60

acaagaagta ctccattggg ctcgatatcg gcacaaacag cgtcggctgg gccgtcatta      120

cggacgagta caaggtgccg agcaaaaaat tcaaagttct gggcaatacc gatcgccaca      180

gcataaagaa gaacctcatt ggcgccctcc tgttcgactc cggggagacg gccgaagcca      240

cgcggctcaa aagaacagca cggcgcagat atacccgcag aaagaatcgg atctgctacc      300

tgcaggagat ctttagtaat gagatggcta aggtggatga ctctttcttc cataggctgg      360

aggagtcctt tttggtggag gaggataaaa agcacgagcg ccacccaatc tttggcaata      420

tcgtggacga ggtggcgtac catgaaaagt acccaaccat atatcatctg aggaagaagc      480

ttgtagacag tactgataag gctgacttgc ggttgatcta tctcgcgctg gcgcatatga      540

tcaaatttcg gggacacttc ctcatcgagg gggacctgaa cccagacaac agcgatgtcg      600

acaaactctt tatccaactg gttcagactt acaatcagct tttcgaagag aacccgatca      660

acgcatccgg agttgacgcc aaagcaatcc tgagcgctag gctgtccaaa tcccggcggc      720

tcgaaaacct catcgcacag ctccctgggg agaagaagaa cggcctgttt ggtaatctta      780

tcgccctgtc actcgggctg acccccaact ttaaatctaa cttcgacctg gccgaagatg      840

ccaagcttca actgagcaaa gacacctacg atgatgatct cgacaatctg ctggcccaga      900

tcggcgacca gtacgcagac ctttttttgg cggcaaagaa cctgtcagac gccattctgc      960

tgagtgatat tctgcgagtg aacacggaga tcaccaaagc tccgctgagc gctagtatga     1020

tcaagcgcta tgatgagcac caccaagact tgactttgct gaaggccctt gtcagacagc     1080

aactgcctga gaagtacaag gaaattttct tcgatcagtc taaaaatggc tacgccggat     1140

acattgacgg cggagcaagc caggaggaat tttacaaatt tattaagccc atcttggaaa     1200

aaatggacgg caccgaggag ctgctggtaa agcttaacag agaagatctg ttgcgcaaac     1260

agcgcacttt cgacaatgga agcatccccc accagattca cctgggcgaa ctgcacgcta     1320

tcctcaggcg gcaagaggat ttctacccct ttttgaaaga taacagggaa aagattgaga     1380

aaatcctcac atttcggata ccctactatg taggccccct cgcccgggga aattccagat     1440

tcgcgtggat gactcgcaaa tcagaagaga ccatcactcc ctggaacttc gaggaagtcg     1500

tggataaggg ggcctctgcc cagtccttca tcgaaaggat gactaacttt gataaaaatc     1560

tgcctaacga aaaggtgctt cctaaacact ctctgctgta cgagtacttc acagtttata     1620

acgagctcac caaggtcaaa tacgtcacag aagggatgag aaagccagca ttcctgtctg     1680

gagagcagaa gaaagctatc gtggacctcc tcttcaagac gaaccggaaa gttaccgtga     1740

aacagctcaa agaagactat ttcaaaaaga ttgaatgttt cgactctgtt gaaatcagcg     1800

gagtggagga tcgcttcaac gcatccctgg gaacgtatca cgatctcctg aaaatcatta     1860

aagacaagga cttcctggac aatgaggaga acgaggacat tcttgaggac attgtcctca     1920

cccttacgtt gtttgaagat agggagatga ttgaagaacg cttgaaaact tacgctcatc     1980

tcttcgacga caaagtcatg aaacagctca agaggcgccg atatacagga tgggggcggc     2040

tgtcaagaaa actgatcaat gggatccgag acaagcagag tggaaagaca atcctggatt     2100

ttcttaagtc cgatggattt gccaaccgga acttcatgca gttgatccat gatgactctc     2160

tcacctttaa ggaggacatc cagaaagcac aagtttctgg ccagggggac agtcttcacg     2220

agcacatcgc taatcttgca ggtagcccag ctatcaaaaa gggaatactg cagaccgtta     2280

aggtcgtgga tgaactcgtc aaagtaatgg gaaggcataa gcccgagaat atcgttatcg     2340

agatggcccg agagaaccaa actacccaga agggacagaa gaacagtagg gaaaggatga     2400

agaggattga agagggtata aaagaactgg ggtcccaaat ccttaaggaa cacccagttg     2460

aaaacaccca gcttcagaat gagaagctct acctgtacta cctgcagaac ggcagggaca     2520

tgtacgtgga tcaggaactg gacatcaatc ggctctccga ctacgacgtg gatcatatcg     2580

tgccccagtc ttttctcaaa gatgattcta ttgataataa agtgttgaca agatccgata     2640

aaaatagagg gaagagtgat aacgtcccct cagaagaagt tgtcaagaaa atgaaaaatt     2700

attggcggca gctgctgaac gccaaactga tcacacaacg gaagttcgat aatctgacta     2760

aggctgaacg aggtggcctg tctgagttgg ataaagccgg cttcatcaaa aggcagcttg     2820

ttgagacacg ccagatcacc aagcacgtgg cccaaattct cgattcacgc atgaacacca     2880

agtacgatga aaatgacaaa ctgattcgag aggtgaaagt tattactctg aagtctaagc     2940

tggtctcaga tttcagaaag gactttcagt tttataaggt gagagagatc aacaattacc     3000

accatgcgca tgatgcctac ctgaatgcag tggtaggcac tgcacttatc aaaaaatatc     3060

ccaagcttga atctgaattt gtttacggag actataaagt gtacgatgtt aggaaaatga     3120

tcgcaaagtc tgagcaggaa ataggcaagg ccaccgctaa gtacttcttt tacagcaata     3180

ttatgaattt tttcaagacc gagattacac tggccaatgg agagattcgg aagcgaccac     3240

ttatcgaaac aaacggagaa acaggagaaa tcgtgtggga caagggtagg gatttcgcga     3300

cagtccggaa ggtcctgtcc atgccgcagg tgaacatcgt taaaaagacc gaagtacaga     3360

ccggaggctt ctccaaggaa agtatcctcc cgaaaaggaa cagcgacaag ctgatcgcac     3420

gcaaaaaaga ttgggacccc aagaaatacg gcggattcga ttctcctaca gtcgcttaca     3480

gtgtactggt tgtggccaaa gtggagaaag ggaagtctaa aaaactcaaa agcgtcaagg     3540

aactgctggg catcacaatc atggagcgat caagcttcga aaaaaacccc atcgactttc     3600

tcgaggcgaa aggatataaa gaggtcaaaa aagacctcat cattaagctt cccaagtact     3660

ctctctttga gcttgaaaac ggccggaaac gaatgctcgc tagtgcgggc gagctgcaga     3720

aaggtaacga gctggcactg ccctctaaat acgttaattt cttgtatctg gccagccact     3780

atgaaaagct caaagggtct cccgaagata atgagcagaa gcagctgttc gtggaacaac     3840

acaaacacta ccttgatgag atcatcgagc aaataagcga attctccaaa agagtgatcc     3900

tcgccgacgc taacctcgat aaggtgcttt ctgcttacaa taagcacagg gataagccca     3960

tcagggagca ggcagaaaac attatccact tgtttactct gaccaacttg ggcgcgcctg     4020

cagccttcaa gtacttcgac accaccatag acagaaagcg gtacacctct acaaaggagg     4080

tcctggacgc cacactgatt catcagtcaa ttacggggct ctatgaaaca agaatcgacc     4140

tctctcagct cggtggagac tga                                             4163


<210>  11
<211>  4145
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11
gatccatgaa aagcttcatt acaaggaaca agacagccat tgacaagaag tactccattg       60

ggctcgatat cggcacaaac agcgtcggct gggccgtcat tacggacgag tacaaggtgc      120

cgagcaaaaa attcaaagtt ctgggcaata ccgatcgcca cagcataaag aagaacctca      180

ttggcgccct cctgttcgac tccggggaga cggccgaagc cacgcggctc aaaagaacag      240

cacggcgcag atatacccgc agaaagaatc ggatctgcta cctgcaggag atctttagta      300

atgagatggc taaggtggat gactctttct tccataggct ggaggagtcc tttttggtgg      360

aggaggataa aaagcacgag cgccacccaa tctttggcaa tatcgtggac gaggtggcgt      420

accatgaaaa gtacccaacc atatatcatc tgaggaagaa gcttgtagac agtactgata      480

aggctgactt gcggttgatc tatctcgcgc tggcgcatat gatcaaattt cggggacact      540

tcctcatcga gggggacctg aacccagaca acagcgatgt cgacaaactc tttatccaac      600

tggttcagac ttacaatcag cttttcgaag agaacccgat caacgcatcc ggagttgacg      660

ccaaagcaat cctgagcgct aggctgtcca aatcccggcg gctcgaaaac ctcatcgcac      720

agctccctgg ggagaagaag aacggcctgt ttggtaatct tatcgccctg tcactcgggc      780

tgacccccaa ctttaaatct aacttcgacc tggccgaaga tgccaagctt caactgagca      840

aagacaccta cgatgatgat ctcgacaatc tgctggccca gatcggcgac cagtacgcag      900

accttttttt ggcggcaaag aacctgtcag acgccattct gctgagtgat attctgcgag      960

tgaacacgga gatcaccaaa gctccgctga gcgctagtat gatcaagcgc tatgatgagc     1020

accaccaaga cttgactttg ctgaaggccc ttgtcagaca gcaactgcct gagaagtaca     1080

aggaaatttt cttcgatcag tctaaaaatg gctacgccgg atacattgac ggcggagcaa     1140

gccaggagga attttacaaa tttattaagc ccatcttgga aaaaatggac ggcaccgagg     1200

agctgctggt aaagcttaac agagaagatc tgttgcgcaa acagcgcact ttcgacaatg     1260

gaagcatccc ccaccagatt cacctgggcg aactgcacgc tatcctcagg cggcaagagg     1320

atttctaccc ctttttgaaa gataacaggg aaaagattga gaaaatcctc acatttcgga     1380

taccctacta tgtaggcccc ctcgcccggg gaaattccag attcgcgtgg atgactcgca     1440

aatcagaaga gaccatcact ccctggaact tcgaggaagt cgtggataag ggggcctctg     1500

cccagtcctt catcgaaagg atgactaact ttgataaaaa tctgcctaac gaaaaggtgc     1560

ttcctaaaca ctctctgctg tacgagtact tcacagttta taacgagctc accaaggtca     1620

aatacgtcac agaagggatg agaaagccag cattcctgtc tggagagcag aagaaagcta     1680

tcgtggacct cctcttcaag acgaaccgga aagttaccgt gaaacagctc aaagaagact     1740

atttcaaaaa gattgaatgt ttcgactctg ttgaaatcag cggagtggag gatcgcttca     1800

acgcatccct gggaacgtat cacgatctcc tgaaaatcat taaagacaag gacttcctgg     1860

acaatgagga gaacgaggac attcttgagg acattgtcct cacccttacg ttgtttgaag     1920

atagggagat gattgaagaa cgcttgaaaa cttacgctca tctcttcgac gacaaagtca     1980

tgaaacagct caagaggcgc cgatatacag gatgggggcg gctgtcaaga aaactgatca     2040

atgggatccg agacaagcag agtggaaaga caatcctgga ttttcttaag tccgatggat     2100

ttgccaaccg gaacttcatg cagttgatcc atgatgactc tctcaccttt aaggaggaca     2160

tccagaaagc acaagtttct ggccaggggg acagtcttca cgagcacatc gctaatcttg     2220

caggtagccc agctatcaaa aagggaatac tgcagaccgt taaggtcgtg gatgaactcg     2280

tcaaagtaat gggaaggcat aagcccgaga atatcgttat cgagatggcc cgagagaacc     2340

aaactaccca gaagggacag aagaacagta gggaaaggat gaagaggatt gaagagggta     2400

taaaagaact ggggtcccaa atccttaagg aacacccagt tgaaaacacc cagcttcaga     2460

atgagaagct ctacctgtac tacctgcaga acggcaggga catgtacgtg gatcaggaac     2520

tggacatcaa tcggctctcc gactacgacg tggatcatat cgtgccccag tcttttctca     2580

aagatgattc tattgataat aaagtgttga caagatccga taaaaataga gggaagagtg     2640

ataacgtccc ctcagaagaa gttgtcaaga aaatgaaaaa ttattggcgg cagctgctga     2700

acgccaaact gatcacacaa cggaagttcg ataatctgac taaggctgaa cgaggtggcc     2760

tgtctgagtt ggataaagcc ggcttcatca aaaggcagct tgttgagaca cgccagatca     2820

ccaagcacgt ggcccaaatt ctcgattcac gcatgaacac caagtacgat gaaaatgaca     2880

aactgattcg agaggtgaaa gttattactc tgaagtctaa gctggtctca gatttcagaa     2940

aggactttca gttttataag gtgagagaga tcaacaatta ccaccatgcg catgatgcct     3000

acctgaatgc agtggtaggc actgcactta tcaaaaaata tcccaagctt gaatctgaat     3060

ttgtttacgg agactataaa gtgtacgatg ttaggaaaat gatcgcaaag tctgagcagg     3120

aaataggcaa ggccaccgct aagtacttct tttacagcaa tattatgaat tttttcaaga     3180

ccgagattac actggccaat ggagagattc ggaagcgacc acttatcgaa acaaacggag     3240

aaacaggaga aatcgtgtgg gacaagggta gggatttcgc gacagtccgg aaggtcctgt     3300

ccatgccgca ggtgaacatc gttaaaaaga ccgaagtaca gaccggaggc ttctccaagg     3360

aaagtatcct cccgaaaagg aacagcgaca agctgatcgc acgcaaaaaa gattgggacc     3420

ccaagaaata cggcggattc gattctccta cagtcgctta cagtgtactg gttgtggcca     3480

aagtggagaa agggaagtct aaaaaactca aaagcgtcaa ggaactgctg ggcatcacaa     3540

tcatggagcg atcaagcttc gaaaaaaacc ccatcgactt tctcgaggcg aaaggatata     3600

aagaggtcaa aaaagacctc atcattaagc ttcccaagta ctctctcttt gagcttgaaa     3660

acggccggaa acgaatgctc gctagtgcgg gcgagctgca gaaaggtaac gagctggcac     3720

tgccctctaa atacgttaat ttcttgtatc tggccagcca ctatgaaaag ctcaaagggt     3780

ctcccgaaga taatgagcag aagcagctgt tcgtggaaca acacaaacac taccttgatg     3840

agatcatcga gcaaataagc gaattctcca aaagagtgat cctcgccgac gctaacctcg     3900

ataaggtgct ttctgcttac aataagcaca gggataagcc catcagggag caggcagaaa     3960

acattatcca cttgtttact ctgaccaact tgggcgcgcc tgcagccttc aagtacttcg     4020

acaccaccat agacagaaag cggtacacct ctacaaagga ggtcctggac gccacactga     4080

ttcatcagtc aattacgggg ctctatgaaa caagaatcga cctctctcag ctcggtggag     4140

actga                                                                 4145


<210>  12
<211>  23
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  12
ttctttgaag tatcaggagg tgg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  13
atgattattg caattccaac agg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  14
gctattttta gtggtatggc agg                                               23


<210>  15
<211>  24
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  15
accatgtaaa tattgtgaac cagg                                              24


<210>  16
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  tracrRNA

<400>  16
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtg                                                        75


<210>  17
<211>  269
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  17
tctttgaaaa gataatgtat gattatgctt tcactcatat ttatacagaa acttgatgtt       60

ttctttcgag tatatacaag gtgattacat gtacgtttga agtacaactc tagattttgt      120

agtgccctct tgggctagcg gtaaaggtgc gcattttttc acaccctaca atgttctgtt      180

caaaagattt tggtcaaacg ctgtagaagt gaaagttggt gcgcatgttt cggcgttcga      240

aacttctccg cagtgaaaga taaatgatc                                        269


<210>  18
<211>  20
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  18
tttttttgtt ttttatgtct                                                   20


<210>  19
<211>  75
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  19
tatatattat gtattattat ataaatatat atatatatta tattataagt aataataagt       60

attatattat atata                                                        75


<210>  20
<211>  75
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  20
gcttttatag cttagtggta aagcgataaa ttgaagattt atttacatgt agttcgattc       60

tcattaaggg caata                                                        75


<210>  21
<211>  76
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  21
aggagattag cttaattggt atagcattcg ttttacacac gaaagattat aggttcgaac       60

cctatatttc ctaaat                                                       76


<210>  22
<211>  118
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  22
ttattaataa ttaacaataa ttaatatatt ataatttata tatatatatt ttatattatt       60

ataataatat tcttacaaat ataattatta tatattattc cttcaaaact cctaacgg        118


<210>  23
<211>  76
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  23
gagcttgtat agtttaattg gttaaaacat ttgtctcata aataaataat gtaaggttca       60

attccttcta caagta                                                       76


<210>  24
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Phe Phe Ser Ala Ala Leu Arg Ala Arg Ala Ala Gly Leu Thr Ala 
1               5                   10                  15      


His Trp Gly Arg His Val Arg Asn Leu His Lys Thr Val Met Gln Asn 
            20                  25                  30          


<210>  25
<211>  4200
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  25
atgttcttct ccgcggcgct ccgggcccgg gcggctggcc tcaccgccca ctggggaaga       60

catgtaagga atttgcataa gacagttatg caaaatgaca agaagtactc cattgggctc      120

gatatcggca caaacagcgt cggctgggcc gtcattacgg acgagtacaa ggtgccgagc      180

aaaaaattca aagttctggg caataccgat cgccacagca taaagaagaa cctcattggc      240

gccctcctgt tcgactccgg ggagacggcc gaagccacgc ggctcaaaag aacagcacgg      300

cgcagatata cccgcagaaa gaatcggatc tgctacctgc aggagatctt tagtaatgag      360

atggctaagg tggatgactc tttcttccat aggctggagg agtccttttt ggtggaggag      420

gataaaaagc acgagcgcca cccaatcttt ggcaatatcg tggacgaggt ggcgtaccat      480

gaaaagtacc caaccatata tcatctgagg aagaagcttg tagacagtac tgataaggct      540

gacttgcggt tgatctatct cgcgctggcg catatgatca aatttcgggg acacttcctc      600

atcgaggggg acctgaaccc agacaacagc gatgtcgaca aactctttat ccaactggtt      660

cagacttaca atcagctttt cgaagagaac ccgatcaacg catccggagt tgacgccaaa      720

gcaatcctga gcgctaggct gtccaaatcc cggcggctcg aaaacctcat cgcacagctc      780

cctggggaga agaagaacgg cctgtttggt aatcttatcg ccctgtcact cgggctgacc      840

cccaacttta aatctaactt cgacctggcc gaagatgcca agcttcaact gagcaaagac      900

acctacgatg atgatctcga caatctgctg gcccagatcg gcgaccagta cgcagacctt      960

tttttggcgg caaagaacct gtcagacgcc attctgctga gtgatattct gcgagtgaac     1020

acggagatca ccaaagctcc gctgagcgct agtatgatca agcgctatga tgagcaccac     1080

caagacttga ctttgctgaa ggcccttgtc agacagcaac tgcctgagaa gtacaaggaa     1140

attttcttcg atcagtctaa aaatggctac gccggataca ttgacggcgg agcaagccag     1200

gaggaatttt acaaatttat taagcccatc ttggaaaaaa tggacggcac cgaggagctg     1260

ctggtaaagc ttaacagaga agatctgttg cgcaaacagc gcactttcga caatggaagc     1320

atcccccacc agattcacct gggcgaactg cacgctatcc tcaggcggca agaggatttc     1380

tacccctttt tgaaagataa cagggaaaag attgagaaaa tcctcacatt tcggataccc     1440

tactatgtag gccccctcgc ccggggaaat tccagattcg cgtggatgac tcgcaaatca     1500

gaagagacca tcactccctg gaacttcgag gaagtcgtgg ataagggggc ctctgcccag     1560

tccttcatcg aaaggatgac taactttgat aaaaatctgc ctaacgaaaa ggtgcttcct     1620

aaacactctc tgctgtacga gtacttcaca gtttataacg agctcaccaa ggtcaaatac     1680

gtcacagaag ggatgagaaa gccagcattc ctgtctggag agcagaagaa agctatcgtg     1740

gacctcctct tcaagacgaa ccggaaagtt accgtgaaac agctcaaaga agactatttc     1800

aaaaagattg aatgtttcga ctctgttgaa atcagcggag tggaggatcg cttcaacgca     1860

tccctgggaa cgtatcacga tctcctgaaa atcattaaag acaaggactt cctggacaat     1920

gaggagaacg aggacattct tgaggacatt gtcctcaccc ttacgttgtt tgaagatagg     1980

gagatgattg aagaacgctt gaaaacttac gctcatctct tcgacgacaa agtcatgaaa     2040

cagctcaaga ggcgccgata tacaggatgg gggcggctgt caagaaaact gatcaatggg     2100

atccgagaca agcagagtgg aaagacaatc ctggattttc ttaagtccga tggatttgcc     2160

aaccggaact tcatgcagtt gatccatgat gactctctca cctttaagga ggacatccag     2220

aaagcacaag tttctggcca gggggacagt cttcacgagc acatcgctaa tcttgcaggt     2280

agcccagcta tcaaaaaggg aatactgcag accgttaagg tcgtggatga actcgtcaaa     2340

gtaatgggaa ggcataagcc cgagaatatc gttatcgaga tggcccgaga gaaccaaact     2400

acccagaagg gacagaagaa cagtagggaa aggatgaaga ggattgaaga gggtataaaa     2460

gaactggggt cccaaatcct taaggaacac ccagttgaaa acacccagct tcagaatgag     2520

aagctctacc tgtactacct gcagaacggc agggacatgt acgtggatca ggaactggac     2580

atcaatcggc tctccgacta cgacgtggat catatcgtgc cccagtcttt tctcaaagat     2640

gattctattg ataataaagt gttgacaaga tccgataaaa atagagggaa gagtgataac     2700

gtcccctcag aagaagttgt caagaaaatg aaaaattatt ggcggcagct gctgaacgcc     2760

aaactgatca cacaacggaa gttcgataat ctgactaagg ctgaacgagg tggcctgtct     2820

gagttggata aagccggctt catcaaaagg cagcttgttg agacacgcca gatcaccaag     2880

cacgtggccc aaattctcga ttcacgcatg aacaccaagt acgatgaaaa tgacaaactg     2940

attcgagagg tgaaagttat tactctgaag tctaagctgg tctcagattt cagaaaggac     3000

tttcagtttt ataaggtgag agagatcaac aattaccacc atgcgcatga tgcctacctg     3060

aatgcagtgg taggcactgc acttatcaaa aaatatccca agcttgaatc tgaatttgtt     3120

tacggagact ataaagtgta cgatgttagg aaaatgatcg caaagtctga gcaggaaata     3180

ggcaaggcca ccgctaagta cttcttttac agcaatatta tgaatttttt caagaccgag     3240

attacactgg ccaatggaga gattcggaag cgaccactta tcgaaacaaa cggagaaaca     3300

ggagaaatcg tgtgggacaa gggtagggat ttcgcgacag tccggaaggt cctgtccatg     3360

ccgcaggtga acatcgttaa aaagaccgaa gtacagaccg gaggcttctc caaggaaagt     3420

atcctcccga aaaggaacag cgacaagctg atcgcacgca aaaaagattg ggaccccaag     3480

aaatacggcg gattcgattc tcctacagtc gcttacagtg tactggttgt ggccaaagtg     3540

gagaaaggga agtctaaaaa actcaaaagc gtcaaggaac tgctgggcat cacaatcatg     3600

gagcgatcaa gcttcgaaaa aaaccccatc gactttctcg aggcgaaagg atataaagag     3660

gtcaaaaaag acctcatcat taagcttccc aagtactctc tctttgagct tgaaaacggc     3720

cggaaacgaa tgctcgctag tgcgggcgag ctgcagaaag gtaacgagct ggcactgccc     3780

tctaaatacg ttaatttctt gtatctggcc agccactatg aaaagctcaa agggtctccc     3840

gaagataatg agcagaagca gctgttcgtg gaacaacaca aacactacct tgatgagatc     3900

atcgagcaaa taagcgaatt ctccaaaaga gtgatcctcg ccgacgctaa cctcgataag     3960

gtgctttctg cttacaataa gcacagggat aagcccatca gggagcaggc agaaaacatt     4020

atccacttgt ttactctgac caacttgggc gcgcctgcag ccttcaagta cttcgacacc     4080

accatagaca gaaagcggta cacctctaca aaggaggtcc tggacgccac actgattcat     4140

cagtcaatta cggggctcta tgaaacaaga atcgacctct ctcagctcgg tggagactga     4200


<210>  26
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala 
1               5                   10                  15      


Ser Cys Leu Val Leu Ala Ala Arg His 
            20                  25  


<210>  27
<211>  4227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  27
atggctttac ttactgcggc cgcccggctc ttgggaacca agaatgcatc ttgtcttgtt       60

cttgcagccc ggcatatggc tttacttact gcggccgccc ggctcttggg aaccaagaat      120

gcagacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc      180

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      240

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      300

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      360

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      420

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      480

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      540

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      600

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      660

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      720

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      780

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      840

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      900

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      960

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt     1020

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt     1080

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1140

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1200

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1260

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1320

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1380

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1440

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1500

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1560

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1620

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1680

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1740

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1800

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1860

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1920

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1980

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     2040

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     2100

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2160

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2220

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2280

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2340

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2400

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2460

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2520

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2580

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2640

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2700

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2760

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2820

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2880

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2940

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     3000

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     3060

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3120

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3180

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3240

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3300

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3360

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3420

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3480

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3540

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3600

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3660

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3720

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3780

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3840

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3900

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3960

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     4020

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     4080

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4140

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4200

gacctctctc agctcggtgg agactga                                         4227


<210>  28
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  28
gtctggtgag tagtgcatgg ct                                                22


<210>  29
<211>  460
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  29
agccccgcgg ccccgggctg gcggtgtcgg ctgcaatccg gcgggcacgg ccgggccggg       60

ctgggctctt ggggcagcca ggcgcctcct tcagcgccta cggccatacc accctgaacg      120

cgcccgatct cgtctgatct cggaagctaa gcagggtcgg gcctggttag tacttggatg      180

ggagaccacc tgggaatacc gggtgctgta ggctttttct ttggcttttt gctgtttctt      240

tccttttctt ccagacggag tctcgccctc tcgcccaggc tggagtgcgg tggcgccatc      300

tcggctcact gcaagctccg cctcccgggt ccacgccatt ccccggcctc agcctcccga      360

gtagctgggc ctacaggcgc ccgccaccac gcccggccac tttgttctat ttttcctaga      420

gacgggcttt caccctgtta gccgggatgg tctggagctc                            460


<210>  30
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cytC-KH peptide

<400>  30

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Lys His Lys His 
1               5                   10                  15      


Lys His Lys His Lys His Lys His Lys His Lys His Lys His 
            20                  25                  30  


<210>  31
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CPP-KH peptide

<400>  31

Lys Lys Leu Phe Lys Lys Ile Leu Lys Leu Tyr Leu Lys His Lys His 
1               5                   10                  15      


Lys His Lys His Lys His Lys His Lys His Lys His Lys His 
            20                  25                  30  


<210>  32
<211>  958
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  32
tccttgcttc atacctttat aaataaggta atcactaata tattataata ataaaaatta       60

tatatattat atataatcta aatattatat attttaataa atattaatat atatgatatg      120

aatattatta gtttttggga agcgggaatc ccgtaaggag tgagggaccc ctccctaacg      180

ggaggaggac cgaaggagtt ttagtatttt ttttttttta ataaaatata tatttatatg      240

attaataata ttatatatat tatttataaa aataatatat aattttaatt atttttaata      300

aaaaaaggtg gggttgataa tataatataa tattttttat tttaatttat aatatataat      360

aataaattat aaataaattt taattaaaag tagtattaac atattataaa tagacaaaag      420

agtctaaagg ttaagattta ttaaaatgtt agatttatta agattacaat taacaacatt      480

cattatgaat gatgtaccaa caccttatgc atgttatttt caggattcag caacaccaaa      540

tcaagaaggt attttagaat tacatgataa tattatgttt tatttattag ttattttagg      600

tttagtatct tgaatgttat atacaattgt tataacatat tcaaaaaatc ctattgcata      660

taaatatatt aaacatggac aaactattga agttatttga acaatttttc cagctgtaat      720

tttattaatt attgcttttc cttcatttat tttattatat ttatgtgatg aagttatttc      780

accagctata actattaaag ctattggata tcaatgatat tgaaaatatg aatattcaga      840

ttttattaat gatagtggtg aaactgttga atttgaatca tatgttattc ctgatgaatt      900

attagaagaa ggtcaattaa gattattaga tactgatact tctatagttg tacctgta        958


<210>  33
<211>  629
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  33
attatcaatg atttatatta ataataaata taaataataa aaaatatata taatataata       60

taataaatat atttccttta atattaataa attaataata ataataataa taataataaa      120

atatttaaat aaattatatt caatacaaat taattattta tattattaat aattgaataa      180

ataatccggt cgaaagagat attaattcga ttatattatt tatttaatta tatttaattt      240

aaatatataa attaatatat atatattgaa ttatatataa atttatttta taattttata      300

aataatatat tattataaat atttaatata atttatatta ttattaaata aaagatttat      360

taaattaata ttattattta attttattat atagtttaag ggataatatt ttattaatat      420

tttttttatt tatttattta attatattat atatataata tatatataac aataaattta      480

tgacacattt agaaagaagt agacatcaac aacatccatt tcatatggtt atgccttcac      540

catgacctat tgtagtatca tttgcattat tatcattagc attatcacta gcattaacaa      600

tgcatggtta tattggtaat atgaatatg                                        629


<210>  34
<211>  2332
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  34
aattcgagct cggtacccgg ggatcaccta aatatgtagc ttcagctaca atatctctaa       60

atcataaaat agaacttgtt aataatacaa ataatgctaa atataccata ttcatattac      120

caatataacc atgcattgtt aatgctagtg ataatgctaa tgataataat gcaaatgata      180

ctacaattgg tcatggtgaa ggcataacca tatgaaatgg atgttgttga tgtctacttc      240

tttctaaatg tgtcataaat ttattgttat atatatatta tatatataat ataattaaat      300

aaataaataa aaaaaatatt aataaaatat tatcctcaaa actatataat aaaattaaat      360

aataatatta atttaataaa tcttttattt aataataata taaattatat taaatattta      420

taataatata ttatttataa aattataaaa taaatttata tataattcaa tatatatata      480

ttaatttata tatttaaatt aaatataatt aaataaataa tataatcgaa ttaatatctc      540

tttcgaccgg attatttatt caattattaa taatataaat aattaatttg tattgaatat      600

aatttattta aatattttat tattattatt attattatta ttaatttatt aatattaaag      660

gaaatatatt tattatatta tattatatat attttttatt atttatattt attattaata      720

taaatcattg ataatatctt ctttttattt atttattatt ataattaaaa agaatcttat      780

attagacctg cagataaggt gattgaatag aatataaatc tatatcttta ttatatttaa      840

gaatattatt ataattatta ttattattat tatttttaat aattaaaaat attaataata      900

agtaaatatt aaggatcctt aagcatatac agcttcgata gctttttcga aagcatccat      960

accttcttcg attaattcat cttcgattgt taaagcaggt acgaatctta ctgttgattt     1020

accagctgtg atgattaata aacctaattc tctagctttt ttgattactt ctgttggagg     1080

ttctacaaat tcagcaccta acattaaacc tttacctctg attgttttga tttgattagg     1140

atatttagct tggatttctc ttaatctttt ttgtaagata tctgattttt ttgatacttg     1200

ttttaagaat gcttcatcag caattgtatc taatacataa tttgatactg aacaagctaa     1260

aggattacca ccatatgttg taccatgatc acctactctt aaagcattat ttactttttc     1320

atttacgatt gtagcagcaa tagggaaacc attacctaat gctttagctg atgtgaaaat     1380

atcaggatga gcttctgaag gtaaataagc atgagctcat aatttacctg atctacctaa     1440

accacattga atttcatcat gaattacgat tacatcatta tcttgacaga ttttttttaa     1500

accagttaat ttttctactt ctacaggaaa tacaccacct tcaccttgaa taggttctac     1560

gattaaacca gcgatttcat ctttttttgt ttcgatatat gattgtaatt ttgtcatttc     1620

atcatttaaa tttaagaatg atacatgagg tactaaatca ccgaaaggtg ttctatattt     1680

tgaatttcat gttactgata aagcacccat tgttctacca tggaatgaat tttcgaaagc     1740

tacaatacct tgtttactag gatttttcat gataccatgt tttttagcga attttaatgc     1800

agcttcatta gcttcggtac ctgaattaca taagaatact cttgaagcat catgttgacc     1860

accgaattgt tttgtttttt ctacgatttt ttctgataaa tctaaacatt cttttgtgaa     1920

atataaattt gatgaatgta ctaatttatt agcttgatga tgtaagattt cagctacttt     1980

aggattagca tgacctaaag ctgttacagc aataccagct gtgaaatcga tatattcttt     2040

accatttaca tcatcatata atttagcatt tttacctctt gtgatacata aatcttcagg     2100

tcttgaatat gttgttactt gaaaagcttt ttcttctaag attgatgtga atcttcttga     2160

tgatgttgat gataaatatc ttttgaacat tttaataaat cttaaccttt agactctttt     2220

gtctatttat aatatgttaa tactactttt aattaaaatt tatttataat ttattattat     2280

atattataaa taaaataaaa atattatatt accaaacccc accactagaa gc             2332


<210>  35
<211>  6741
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  35
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gaatttaata      240

cgactcacta tagggaattc gagctcggta cccggggatc acctaaatat gtagcttcag      300

ctacaatatc tctaaatcat aaaatagaac ttgttaataa tacaaataat gctaaatata      360

ccatattcat attaccaata taaccatgca ttgttaatgc tagtgataat gctaatgata      420

ataatgcaaa tgatactaca attggtcatg gtgaaggcat aaccatatga aatggatgtt      480

gttgatgtct acttctttct aaatgtgtca taaatttatt gttatatata tattatatat      540

ataatataat taaataaata aataaaaaaa atattaataa aatattatcc tcaaaactat      600

ataataaaat taaataataa tattaattta ataaatcttt tatttaataa taatataaat      660

tatattaaat atttataata atatattatt tataaaatta taaaataaat ttatatataa      720

ttcaatatat atatattaat ttatatattt aaattaaata taattaaata aataatataa      780

tcgaattaat atctctttcg accggattat ttattcaatt attaataata taaataatta      840

atttgtattg aatataattt atttaaatat tttattatta ttattattat tattattaat      900

ttattaatat taaaggaaat atatttatta tattatatta tatatatttt ttattattta      960

tatttattat taatataaat cattgataat atcttctttt tatttattta ttattataat     1020

taaaaagaat cttatattag acctgcagat aaggtgattg aatagaatat aaatctatat     1080

ctttattata tttaagaata ttattataat tattattatt attattattt ttaataatta     1140

aaaatattaa taataagtaa atattaagga tccttaagca tatacagctt cgatagcttt     1200

ttcgaaagca tccatacctt cttcgattaa ttcatcttcg attgttaaag caggtacgaa     1260

tcttactgtt gatttaccag ctgtgatgat taataaacct aattctctag cttttttgat     1320

tacttctgtt ggaggttcta caaattcagc acctaacatt aaacctttac ctctgattgt     1380

tttgatttga ttaggatatt tagcttggat ttctcttaat cttttttgta agatatctga     1440

tttttttgat acttgtttta agaatgcttc atcagcaatt gtatctaata cataatttga     1500

tactgaacaa gctaaaggat taccaccata tgttgtacca tgatcaccta ctcttaaagc     1560

attatttact ttttcattta cgattgtagc agcaataggg aaaccattac ctaatgcttt     1620

agctgatgtg aaaatatcag gatgagcttc tgaaggtaaa taagcatgag ctcataattt     1680

acctgatcta cctaaaccac attgaatttc atcatgaatt acgattacat cattatcttg     1740

acagattttt tttaaaccag ttaatttttc tacttctaca ggaaatacac caccttcacc     1800

ttgaataggt tctacgatta aaccagcgat ttcatctttt tttgtttcga tatatgattg     1860

taattttgtc atttcatcat ttaaatttaa gaatgataca tgaggtacta aatcaccgaa     1920

aggtgttcta tattttgaat ttcatgttac tgataaagca cccattgttc taccatggaa     1980

tgaattttcg aaagctacaa taccttgttt actaggattt ttcatgatac catgtttttt     2040

agcgaatttt aatgcagctt cattagcttc ggtacctgaa ttacataaga atactcttga     2100

agcatcatgt tgaccaccga attgttttgt tttttctacg attttttctg ataaatctaa     2160

acattctttt gtgaaatata aatttgatga atgtactaat ttattagctt gatgatgtaa     2220

gatttcagct actttaggat tagcatgacc taaagctgtt acagcaatac cagctgtgaa     2280

atcgatatat tctttaccat ttacatcatc atataattta gcatttttac ctcttgtgat     2340

acataaatct tcaggtcttg aatatgttgt tacttgaaaa gctttttctt ctaagattga     2400

tgtgaatctt cttgatgatg ttgatgataa atatcttttg aacattttaa taaatcttaa     2460

cctttagact cttttgtcta tttataatat gttaatacta cttttaatta aaatttattt     2520

ataatttatt attatatatt ataaataaaa taaaaatatt atattaccaa accccaccac     2580

tagaagcggc cgctatatat tatgtattat tatataaata tatatatata ttatattata     2640

agtaataata agtattatat tatatatagc ttttatagct tagtggtaaa gcgataaatt     2700

gaagatttat ttacatgtag ttcgattctc attaagggca atatagctat ttttagtggt     2760

atggcgtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa     2820

aaagtggcac cgagtcggtg ctaggagatt agcttaattg gtatagcatt cgttttacac     2880

acgaaagatt ataggttcga accctatatt tcctaaatac catgtaaata ttgtgaaccg     2940

ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact tgaaaaagtg     3000

gcaccgagtc ggtgctgagc ttgtatagtt taattggtta aaacatttgt ctcataaata     3060

aataatgtaa ggttcaattc cttctacaag tattattaat aattaacaat aattaatata     3120

ttataattta tatatatata ttttatatta ttataataat attcttacaa atataattat     3180

tatatattat tccttcaaaa ctcctaacgg caccatggac tgtttttaag tatctattga     3240

tgattcataa tactaatgct agacgcatca acgaaatata cgcactgaga ggcgcaccat     3300

taaataattg tgaattacca tgtttattta tataattcat ccataccatg tgtgatacca     3360

gcagctgtta caaattctaa taataccata tgatctcttt tttcattagg atcttttgat     3420

aaagctgatt gtgtacttaa gtaatgatta tcaggtaata atacaggacc atcaccgata     3480

ggtgtatttt gttgataatg atctgctaat tgtactgaac cgtcttcgat attatgtctg     3540

attttgaaat ttactttgat accatttttt tgtttatcag ccatgatata tacattatgt     3600

gaattataat tatattctaa tttatgacct aagatattac catcttcttt gaaatcgata     3660

ccttttaact cgattctatt tactaatgta tcaccttcga attttacttc agctcttgtt     3720

ttataattac catcatcttt gaagaagatt gttctttctt gtacgtaacc ttcaggcatt     3780

gctgatttga agaaatcatg ttgtttcata tgatcaggat atcttgcgaa acattgtact     3840

ccatatccga atgttgttac taatgtaggt caaggtacag gtaatttacc tgttgtacag     3900

atgaatttta atgttaattt accatatgta gcatcacctt caccttcacc tgatactgag     3960

aatttatgac catttacatc accatctaat tctactaaga taggtactac tccagtgaat     4020

aattcttcac cttttgacat ttgtctactt ctttctaaat gtgtcatacc agctgctgaa     4080

ccagcagaac ctgataacat accactaaaa atagctaaca taaaatataa tactgcaata     4140

tcttttgcat ttgttgaata taatcatctt tgtaccattc catggaaagc ttggcactgg     4200

ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg     4260

cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt     4320

cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg     4380

cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg     4440

ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc     4500

taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa     4560

aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc     4620

ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac     4680

tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt     4740

ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt     4800

ttacaatttc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     4860

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     4920

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     4980

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     5040

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     5100

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     5160

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     5220

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     5280

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     5340

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     5400

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     5460

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     5520

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     5580

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     5640

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     5700

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     5760

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     5820

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     5880

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     5940

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     6000

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     6060

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     6120

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     6180

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     6240

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     6300

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     6360

agcattgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     6420

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     6480

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     6540

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     6600

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     6660

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     6720

cagtgagcga ggaagcggaa g                                               6741


<210>  36
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  KH-AtOEP34 peptide

<400>  36

Lys His Lys His Lys His Lys His Lys His Lys His Lys His Lys His 
1               5                   10                  15      


Lys His Met Phe Ala Phe Gln Tyr Leu Leu Val Met 
            20                  25              


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAT peptide

<400>  37

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R9 peptide

<400>  38

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  39
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pep-1 peptide

<400>  39

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  40
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MPG peptide

<400>  40

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  41
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gamma-ZEIN peptide

<400>  41

Val Arg Leu Pro Pro Pro 
1               5       


<210>  42
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Transporant peptide

<400>  42

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  43
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAP peptide

<400>  43

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  44
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pept 1 peptide

<400>  44

Pro Leu Ile Leu Leu Arg Leu Leu Arg Gly Gln Phe 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pept 2 peptide

<400>  45

Pro Leu Ile Tyr Leu Arg Leu Leu Arg Gly Gln Phe 
1               5                   10          


<210>  46
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IVV-14 peptide

<400>  46

Lys Leu Trp Met Arg Trp Tyr Ser Pro Thr Thr Arg Arg Tyr Gly 
1               5                   10                  15  


<210>  47
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Igv peptide

<400>  47

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Lys Lys Lys Arg Lys Val 
            20              


<210>  48
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amphiphilic peptide

<400>  48

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  49
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  pVEC peptide

<400>  49

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  50
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HRSV peptide

<400>  50

Arg Arg Ile Pro Asn Arg Arg Pro Arg Arg 
1               5                   10  


<210>  51
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bp100 peptide

<400>  51

Lys Lys Leu Phe Lys Lys Ile Leu Lys Tyr Leu 
1               5                   10      


<210>  52
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAT2 peptide

<400>  52

Arg Lys Lys Arg Arg Gln Arg Arg Arg Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  53
<211>  25
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  53

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu 
            20                  25  


<210>  54
<211>  1395
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MTS-Cas9 fusion protein

<400>  54

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu Asp Lys Lys Tyr Ser Ile Gly 
            20                  25                  30          


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
        35                  40                  45              


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
    50                  55                  60                  


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
65                  70                  75                  80  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
                85                  90                  95      


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
            100                 105                 110         


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
        115                 120                 125             


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
    130                 135                 140                 


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
145                 150                 155                 160 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
                165                 170                 175     


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
            180                 185                 190         


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
        195                 200                 205             


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
    210                 215                 220                 


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
225                 230                 235                 240 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
                245                 250                 255     


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
            260                 265                 270         


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
        275                 280                 285             


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
    290                 295                 300                 


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
305                 310                 315                 320 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
                325                 330                 335     


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
            340                 345                 350         


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
        355                 360                 365             


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
    370                 375                 380                 


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
385                 390                 395                 400 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
                405                 410                 415     


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
            420                 425                 430         


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
        435                 440                 445             


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
    450                 455                 460                 


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
465                 470                 475                 480 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
                485                 490                 495     


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
            500                 505                 510         


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
        515                 520                 525             


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
    530                 535                 540                 


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
545                 550                 555                 560 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
                565                 570                 575     


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
            580                 585                 590         


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
        595                 600                 605             


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
    610                 615                 620                 


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
625                 630                 635                 640 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
                645                 650                 655     


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
            660                 665                 670         


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
        675                 680                 685             


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
    690                 695                 700                 


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
705                 710                 715                 720 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
                725                 730                 735     


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
            740                 745                 750         


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
        755                 760                 765             


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
    770                 775                 780                 


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
785                 790                 795                 800 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
                805                 810                 815     


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
            820                 825                 830         


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
        835                 840                 845             


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
    850                 855                 860                 


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
865                 870                 875                 880 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
                885                 890                 895     


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
            900                 905                 910         


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
        915                 920                 925             


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
    930                 935                 940                 


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
945                 950                 955                 960 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
                965                 970                 975     


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
            980                 985                 990         


Asp Phe Gln Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
        995                 1000                 1005             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1010                 1015                 1020             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1025                 1030                 1035             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1040                 1045                 1050             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1055                 1060                 1065             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1070                 1075                 1080             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1085                 1090                 1095             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1100                 1105                 1110             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1115                 1120                 1125             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1130                 1135                 1140             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1145                 1150                 1155             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1160                 1165                 1170             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1175                 1180                 1185             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1190                 1195                 1200             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1205                 1210                 1215             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1220                 1225                 1230             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1235                 1240                 1245             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1250                 1255                 1260             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1265                 1270                 1275             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1280                 1285                 1290             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1295                 1300                 1305             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1310                 1315                 1320             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1325                 1330                 1335             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1340                 1345                 1350             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Glu Gly Ala  
    1385                 1390                 1395 


<210>  55
<211>  4212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  55
aagcttcgcc accatgcttt cactacgtca atctataaga tttttcaagc cagccacaag       60

aactttgtgt agctctagat atctgcttga caagaagtat tctatcggac tggacatcgg      120

gactaatagc gtcgggtggg ccgtcatcac tgacgagtac aaggtgccct ctaagaagtt      180

caaggtgctc gggaacaccg accggcattc catcaagaaa aatctgatcg gagctctcct      240

ctttgattca ggggagaccg ctgaagcaac ccgcctcaag cggactgcta gacggcggta      300

caccaggagg aagaaccgga tttgttacct tcaagagata ttctccaacg aaatggcaaa      360

ggtcgacgac agcttcttcc ataggctgga agaatcattc ctcgtggaag aggataagaa      420

gcatgaacgg catcccatct tcggtaatat cgtcgacgag gtggcctatc acgagaaata      480

cccaaccatc taccatcttc gcaaaaagct ggtggactca accgacaagg cagacctccg      540

gcttatctac ctggccctgg cccacatgat taagttcaga ggccacttcc tgatcgaggg      600

cgacctcaat cctgacaata gcgatgtgga taaactgttc atccagctgg tgcagactta      660

caaccagctc tttgaagaga accccatcaa tgcaagcgga gtcgatgcca aggccattct      720

gtcagcccgg ctgtcaaaga gccgcagact tgagaatctt atcgctcagc tgccgggtga      780

aaagaaaaat ggactgttcg ggaacctgat tgctctttca cttgggctga ctcccaattt      840

caagtctaat ttcgacctgg cagaggatgc caagctgcaa ctgtccaagg acacctatga      900

tgacgatctc gacaacctcc tggcccagat cggtgaccaa tacgccgacc ttttccttgc      960

tgctaagaat ctttctgacg ccatcctgct gtctgacatt ctccgcgtga acactgaaat     1020

caccaaggcc cctctttcag cttcaatgat taagcggtat gatgagcacc accaggacct     1080

gaccctgctt aaggcactcg tccggcagca gcttccggag aagtacaagg aaatcttctt     1140

tgaccagtca aagaatggat acgccggcta catcgacgga ggtgcctccc aagaggaatt     1200

ttataagttt atcaaaccta tccttgagaa gatggacggc accgaagagc tcctcgtgaa     1260

actgaatcgg gaggatctgc tgcggaagca gcgcactttc gacaatggga gcattcccca     1320

ccagatccat cttggggagc ttcacgccat ccttcggcgc caagaggact tctacccctt     1380

tcttaaggac aacagggaga agattgagaa aattctcact ttccgcatcc cctactacgt     1440

gggacccctc gccagaggaa atagccggtt tgcttggatg accagaaagt cagaagaaac     1500

tatcactccc tggaacttcg aagaggtggt ggacaaggga gccagcgctc agtcattcat     1560

cgaacggatg actaacttcg ataagaacct ccccaatgag aaggtcctgc cgaaacattc     1620

cctgctctac gagtacttta ccgtgtacaa cgagctgacc aaggtgaaat atgtcaccga     1680

agggatgagg aagcccgcat tcctgtcagg cgaacaaaag aaggcaattg tggaccttct     1740

gttcaagacc aatagaaagg tgaccgtgaa gcagctgaag gaggactatt tcaagaaaat     1800

tgaatgcttc gactctgtgg agattagcgg ggtcgaagat cggttcaacg caagcctggg     1860

tacctaccat gatctgctta agatcatcaa ggacaaggat tttctggaca atgaggagaa     1920

cgaggacatc cttgaggaca ttgtcctgac tctcactctg ttcgaggacc gggaaatgat     1980

cgaggagagg cttaagacct acgcccatct gttcgacgat aaagtgatga agcaacttaa     2040

acggagaaga tataccggat ggggacgcct tagccgcaaa ctcatcaacg gaatccggga     2100

caaacagagc ggaaagacca ttcttgattt ccttaagagc gacggattcg ctaatcgcaa     2160

cttcatgcaa cttatccatg atgattccct gacctttaag gaggacatcc agaaggccca     2220

agtgtctgga caaggtgact cactgcacga gcatatcgca aatctggctg gttcacccgc     2280

tattaagaag ggtattctcc agaccgtgaa agtcgtggac gagctggtca aggtgatggg     2340

tcgccataaa ccagagaaca ttgtcatcga gatggccagg gaaaaccaga ctacccagaa     2400

gggacagaag aacagcaggg agcggatgaa aagaattgag gaagggatta aggagctcgg     2460

gtcacagatc cttaaagagc acccggtgga aaacacccag cttcagaatg agaagctcta     2520

tctgtactac cttcaaaatg gacgcgatat gtatgtggac caagagcttg atatcaacag     2580

gctctcagac tacgacgtgg accacatcgt ccctcagagc ttcctcaaag acgactcaat     2640

tgacaataag gtgctgactc gctcagacaa gaaccgggga aagtcagata acgtgccctc     2700

agaggaagtc gtgaaaaaga tgaagaacta ttggcgccag cttctgaacg caaagctaat     2760

cactcagcgg aagttcgaca atctcactaa ggctgagagg ggcggactga gcgaactgga     2820

caaagcagga ttcattaaac ggcaacttgt ggagactcgg cagattacta aacatgtcgc     2880

ccaaatcctt gactcacgca tgaataccaa gtacgacgaa aacgacaaac ttatccgcga     2940

ggtgaaggtg attaccctga agtccaagct ggtcagcgat ttcagaaagg actttcaatt     3000

ctacaaagtg cgggagatca ataactatca tcatgctcat gacgcatatc tgaatgccgt     3060

ggtgggaacc gccctaatca agaagtaccc aaagctggaa agcgagttcg tgtacggaga     3120

ctacaaggtc tacgacgtgc gcaagatgat tgccaaatct gagcaggaga tcggaaaggc     3180

caccgcaaag tacttcttct acagcaacat catgaatttc ttcaagaccg aaatcaccct     3240

tgcaaacggt gagatccgga agaggccgct catcgagact aatggggaga ctggcgaaat     3300

cgtgtgggac aagggcagag atttcgctac cgtgcgcaaa gtgctttcta tgcctcaagt     3360

gaacatcgtg aagaaaaccg aggtgcaaac cggaggcttt tctaaggaat caatcctccc     3420

caagcgcaac tccgacaagc tcattgcaag gaagaaggat tgggacccta agaagtacgg     3480

cggattcgat tcaccaactg tggcttattc tgtcctggtc gtggctaagg tggaaaaagg     3540

aaagtctaag aagctcaaga gcgtgaagga actgctgggt atcaccatta tggagcgcag     3600

ctccttcgag aagaacccaa ttgactttct cgaagccaaa ggttacaagg aagtcaagaa     3660

ggaccttatc atcaagctcc caaagtatag cctgttcgaa ctggagaatg ggcggaagcg     3720

gatgctcgcc tccgctggcg aacttcagaa gggtaatgag ctggctctcc cctccaagta     3780

cgtgaatttc ctctaccttg caagccatta cgagaagctg aaggggagcc ccgaggacaa     3840

cgagcaaaag caactgtttg tggagcagca taagcattat ctggacgaga tcattgagca     3900

gatttccgag ttttctaaac gcgtcattct cgctgatgcc aacctcgata aagtccttag     3960

cgcatacaat aagcacagag acaaaccaat tcgggagcag gctgagaata tcatccacct     4020

gttcaccctc accaatcttg gtgcccctgc cgcattcaag tacttcgaca ccaccatcga     4080

ccggaaacgc tatacctcca ccaaagaagt gctggacgcc accctcatcc accagagcat     4140

caccggactt tacgaaactc ggattgacct ctcacagctc ggaggggatg agggagctta     4200

gttcgcggcc gc                                                         4212


<210>  56
<211>  20
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  56
ttctttgaag tatcaggagg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  57
atgattattg caattccaac                                                   20


<210>  58
<211>  22
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  58
tagctatttt tagtggtatg gc                                                22


<210>  59
<211>  21
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  59
accatgtaaa tattgtgaac c                                                 21


<210>  60
<211>  889
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  60
gcatgcggac aatctttgaa aagataatgt atgattatgc tttcactcat atttatacag       60

aaacttgatg ttttctttcg agtatataca aggtgattac atgtacgttt gaagtacaac      120

tctagatttt gtagtgccct cttgggctag cggtaaaggt gcgcattttt tcacacccta      180

caatgttctg ttcaaaagat tttggtcaaa cgctgtagaa gtgaaagttg gtgcgcatgt      240

ttcggcgttc gaaacttctc cgcagtgaaa gataaatgat catgattatt gcaattccaa      300

cgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag      360

tggcaccgag tcggtggcgc aagtggttta gtggtaaaat ccaacgttgc catcgttggg      420

cccccggttc gattccgggc ttgcgcattc tttgaagtat caggagggtt ttagagctag      480

aaatagcaag ttaaaataag gctagtccgt tatcaacttg aaaaagtggc accgagtcgg      540

tgtttttttg ttttttatgt cttcgagtca tgtaattagt tataagcatg tgagctaaga      600

cactgtaatt gccaatctaa acgataccac ggccgctcta gagaaatggg gagcgatttg      660

caggcatttg ctcggtgcag tatagcgacc agcattcaca tacgattgac gcatgatatt      720

actttctgcg cacttaactt cgcatctggg cagatgatgt cgaggcgaaa aaaaatataa      780

atcacgctaa catttgatta aaatagaaca actacaatat aaaaaaacta tacaaatgac      840

aagttcttga aaacaagaat ctttttattg tcagtctcga ggcggccgc                  889


<210>  61
<211>  892
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  61
gcatgcggac aatctttgaa aagataatgt atgattatgc tttcactcat atttatacag       60

aaacttgatg ttttctttcg agtatataca aggtgattac atgtacgttt gaagtacaac      120

tctagatttt gtagtgccct cttgggctag cggtaaaggt gcgcattttt tcacacccta      180

caatgttctg ttcaaaagat tttggtcaaa cgctgtagaa gtgaaagttg gtgcgcatgt      240

ttcggcgttc gaaacttctc cgcagtgaaa gataaatgat ctagctattt ttagtggtat      300

ggcgttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa      360

agtggcaccg agtcggtggc gcaagtggtt tagtggtaaa atccaacgtt gccatcgttg      420

ggcccccggt tcgattccgg gcttgcgcaa ccatgtaaat attgtgaacc gttttagagc      480

tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt      540

cggtgttttt ttgtttttta tgtcttcgag tcatgtaatt agttataagc atgtgagcta      600

agacactgta attgccaatc taaacgatac cacggccgct ctagagaaat ggggagcgat      660

ttgcaggcat ttgctcggtg cagtatagcg accagcattc acatacgatt gacgcatgat      720

attactttct gcgcacttaa cttcgcatct gggcagatga tgtcgaggcg aaaaaaaata      780

taaatcacgc taacatttga ttaaaataga acaactacaa tataaaaaaa ctatacaaat      840

gacaagttct tgaaaacaag aatcttttta ttgtcagtct cgaggcggcc gc              892


<210>  62
<211>  454
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  62
gcatgcggac aatctttgaa aagataatgt atgattatgc tttcactcat atttatacag       60

aaacttgatg ttttctttcg agtatataca aggtgattac atgtacgttt gaagtacaac      120

tctagatttt gtagtgccct cttgggctag cggtaaaggt gcgcattttt tcacacccta      180

caatgttctg ttcaaaagat tttggtcaaa cgctgtagaa gtgaaagttg gtgcgcatgt      240

ttcggcgttc gaaacttctc cgcagtgaaa gataaatgat cgctattttt agtggtatgg      300

cgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag      360

tggcaccgag tcggtggcgc aagtggttta gtggtaaaat ccaacgttgc catcgttggg      420

cccccggttc gattccgggc ttgcgcatga gacc                                  454


<210>  63
<211>  453
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  63
ggtctcacgc accatgtaaa tattgtgaac cgttttagag ctagaaatag caagttaaaa       60

taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgtttt tttgtttttt      120

atgtcttcga gtcatgtaat tagttataag catgtgagct aagacactgt aattgccaat      180

ctaaacgata ccacggccgc tctagagaaa tggggagcga tttgcaggca tttgctcggt      240

gcagtatagc gaccagcatt cacatacgat tgacgcatga tattactttc tgcgcactta      300

acttcgcatc tgggcagatg atgtcgaggc gaaaaaaaat ataaatcacg ctaacatttg      360

attaaaatag aacaactaca atataaaaaa actatacaaa tgacaagttc ttgaaaacaa      420

gaatcttttt attgtcagtc tcgaggcggc cgc                                   453


<210>  64
<211>  19
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  64
ctatttttag tggtatggc                                                    19


<210>  65
<211>  20
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  65
ccatgtaaat attgtgaacc                                                   20


<210>  66
<211>  889
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  66
gcatgcggac aatctttgaa aagataatgt atgattatgc tttcactcat atttatacag       60

aaacttgatg ttttctttcg agtatataca aggtgattac atgtacgttt gaagtacaac      120

tctagatttt gtagtgccct cttgggctag cggtaaaggt gcgcattttt tcacacccta      180

caatgttctg ttcaaaagat tttggtcaaa cgctgtagaa gtgaaagttg gtgcgcatgt      240

ttcggcgttc gaaacttctc cgcagtgaaa gataaatgat cgctattttt agtggtatgg      300

cgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag      360

tggcaccgag tcggtggcgc aagtggttta gtggtaaaat ccaacgttgc catcgttggg      420

cccccggttc gattccgggc ttgcgcacca tgtaaatatt gtgaaccgtt ttagagctag      480

aaatagcaag ttaaaataag gctagtccgt tatcaacttg aaaaagtggc accgagtcgg      540

tgtttttttg ttttttatgt cttcgagtca tgtaattagt tataagcatg tgagctaaga      600

cactgtaatt gccaatctaa acgataccac ggccgctcta gagaaatggg gagcgatttg      660

caggcatttg ctcggtgcag tatagcgacc agcattcaca tacgattgac gcatgatatt      720

actttctgcg cacttaactt cgcatctggg cagatgatgt cgaggcgaaa aaaaatataa      780

atcacgctaa catttgatta aaatagaaca actacaatat aaaaaaacta tacaaatgac      840

aagttcttga aaacaagaat ctttttattg tcagtctcga ggcggccgc                  889


<210>  67
<211>  987
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  67
aagctttcca tggaatggta caaagatgat tatattcaac aaatgcaaaa gatattgcag       60

tattatattt tatgttagct atttttagtg gtatgttatc aggttctgct ggttcagcag      120

ctggtatgac acatttagaa agaagtagac aaatgtcaaa aggtgaagaa ttattcactg      180

gagtagtacc tatcttagta gaattagatg gtgatgtaaa tggtcataaa ttctcagtat      240

caggtgaagg tgaaggtgat gctacatatg gtaaattaac attaaaattc atctgtacaa      300

caggtaaatt acctgtacct tgacctacat tagtaacaac attcggatat ggagtacaat      360

gtttcgcaag atatcctgat catatgaaac aacatgattt cttcaaatca gcaatgcctg      420

aaggttacgt acaagaaaga acaatcttct tcaaagatga tggtaattat aaaacaagag      480

ctgaagtaaa attcgaaggt gatacattag taaatagaat cgagttaaaa ggtatcgatt      540

tcaaagaaga tggtaatatc ttaggtcata aattagaata taattataat tcacataatg      600

tatatatcat ggctgataaa caaaaaaatg gtatcaaagt aaatttcaaa atcagacata      660

atatcgaaga cggttcagta caattagcag atcattatca acaaaataca cctatcggtg      720

atggtcctgt attattacct gataatcatt acttaagtac acaatcagct ttatcaaaag      780

atcctaatga aaaaagagat catatggtat tattagaatt tgtaacagct gctggtatca      840

cacatggtat ggatgaatta tataaataaa catggtaatt cacaattatt taatggtgcg      900

cctctcagtg cgtatatttc gttgatgcgt ctagcattag tattatgaat catcaataga      960

tacttaaaaa cagtccatgt tctgcag                                          987


<210>  68
<211>  25
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  68
agaatcaggt gctggtacag ggtga                                             25


<210>  69
<211>  22
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  69
ctattcaggc acattcagga cc                                                22


<210>  70
<211>  23
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  70
agaggtatac caacacaaga ttc                                               23


<210>  71
<211>  27
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  71
agatagataa tcaattcaac catctgt                                           27


<210>  72
<211>  41
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  72
attagttcgg tttagttggt attttgtaat gagtaaaaag t                           41


<210>  73
<211>  34
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  73
cctacactaa tcataggtgt tttatgacat gcta                                   34


<210>  74
<211>  27
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  74
agattatgaa agagagtatt aatatca                                           27


<210>  75
<211>  23
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  75
taaagttagc ccctactgag tta                                               23


<210>  76
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  76
caggtgaagg tgaaggtgat gc                                                22


<210>  77
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  77
gatctgctaa ttgtactgaa ccg                                               23


<210>  78
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  78
cagcaatgcc tgaaggttac gtac                                              24


<210>  79
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  79
actaatgtag gtcaaggtac agg                                               23


<210>  80
<211>  1504
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  80
aagcttccat cgaatggtac aaagatgatt atattcaaca aatgcaaaag atattgcagt       60

attatatttt atgttagcta tttttagtgg tatgttatca ggttctgctg gttcagcagc      120

tggtttcaaa agatatttat catcaacatc atcaagaaga ttcacatcaa tcttagaaga      180

aaaagcattt caagtaacaa catattcaag acctgaagat ttatgtatca caagaggtaa      240

aaatgctaaa ttatatgatg atgtaaatgg taaagaatat atcgatttca cagctggtat      300

tgctgtaaca gctttaggtc atgctaatcc taaagtagct gaaatcttac atcatcaagc      360

taataaatta gtacattcat caaatttata tttcacaaaa gaatgtttag atttatcaga      420

aaaaatcgta gaaaaaacaa aacaattcgg tggtcaacat gatgcttcaa gagtattctt      480

atgtaattca ggtaccgaag ctaatgaagc tgcattaaaa ttcgctaaaa aacatggtat      540

catgaaaaat cctagtaaac aaggtattgt agctttcgaa aattcatttc atggtagaac      600

aatgggtgct ttatcagtaa catgaaattc aaaatataga acacctttcg gtgatttagt      660

acctcatgta tcattcttaa atttaaatga tgaaatgaca aaattacaat catatatcga      720

aacaaaaaaa gatgaaatcg ctggtttaat cgtagaacct attcaaggtg aaggtggtgt      780

atttcctgta gaagtagaaa aattaactgg tttaaaaaaa atctgtcaag ataatgatgt      840

aatcgtaatt catgatgaaa ttcaatgtgg tttaggtaga tcaggtaaat tatgagctca      900

tgcttattta ccttcagaag ctcatcctga tattttcaca tcagctaaag cattaggtaa      960

tggtttccct attgctgcta caatcgtaaa tgaaaaagta aataatgctt taagagtagg     1020

tgatcatggt acaacatatg gtggtaatcc tttagcttgt tcagtatcaa attatgtatt     1080

agatacaatt gctgatgaag cattcttaaa acaagtatca aaaaaatcag atatcttaca     1140

aaaaagatta agagaaatcc aagctaaata tcctaatcaa atcaaaacaa tcagaggtaa     1200

aggtttaatg ttaggtgctg aatttgtaga acctccaaca gaagtaatca aaaaagctag     1260

agaattaggt ttattaatca tcacagctgg taaatcaaca gtaagattcg tacctgcttt     1320

aacaatcgaa gatgaattaa tcgaagaagg tatggatgct ttcgaaaaag ctatcgaagc     1380

tgtatatgct taaacatggt aattcacaat tatttaatgg tgcgcctctc agtgcgtata     1440

tttcgttgat gcgtctagca ttagtattat gaatcatcaa tagatactta aaaacagtcc     1500

atgg                                                                  1504


<210>  81
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ARG8m protein

<400>  81

Phe Lys Arg Tyr Leu Ser Ser Thr Ser Ser Arg Arg Phe Thr Ser Ile 
1               5                   10                  15      


Leu Glu Glu Lys Ala Phe Gln Val Thr Thr Tyr Ser Arg Pro Glu Asp 
            20                  25                  30          


Leu Cys Ile Thr Arg Gly Lys Asn Ala Lys Leu Tyr Asp Asp Val Asn 
        35                  40                  45              


Gly Lys Glu Tyr Ile Asp Phe Thr Ala Gly Ile Ala Val Thr Ala Leu 
    50                  55                  60                  


Gly His Ala Asn Pro Lys Val Ala Glu Ile Leu His His Gln Ala Asn 
65                  70                  75                  80  


Lys Leu Val His Ser Ser Asn Leu Tyr Phe Thr Lys Glu Cys Leu Asp 
                85                  90                  95      


Leu Ser Glu Lys Ile Val Glu Lys Thr Lys Gln Phe Gly Gly Gln His 
            100                 105                 110         


Asp Ala Ser Arg Val Phe Leu Cys Asn Ser Gly Thr Glu Ala Asn Glu 
        115                 120                 125             


Ala Ala Leu Lys Phe Ala Lys Lys His Gly Ile Met Lys Asn Pro Ser 
    130                 135                 140                 


Lys Gln Gly Ile Val Ala Phe Glu Asn Ser Phe His Gly Arg Thr Met 
145                 150                 155                 160 


Gly Ala Leu Ser Val Thr Trp Asn Ser Lys Tyr Arg Thr Pro Phe Gly 
                165                 170                 175     


Asp Leu Val Pro His Val Ser Phe Leu Asn Leu Asn Asp Glu Met Thr 
            180                 185                 190         


Lys Leu Gln Ser Tyr Ile Glu Thr Lys Lys Asp Glu Ile Ala Gly Leu 
        195                 200                 205             


Ile Val Glu Pro Ile Gln Gly Glu Gly Gly Val Phe Pro Val Glu Val 
    210                 215                 220                 


Glu Lys Leu Thr Gly Leu Lys Lys Ile Cys Gln Asp Asn Asp Val Ile 
225                 230                 235                 240 


Val Ile His Asp Glu Ile Gln Cys Gly Leu Gly Arg Ser Gly Lys Leu 
                245                 250                 255     


Trp Ala His Ala Tyr Leu Pro Ser Glu Ala His Pro Asp Ile Phe Thr 
            260                 265                 270         


Ser Ala Lys Ala Leu Gly Asn Gly Phe Pro Ile Ala Ala Thr Ile Val 
        275                 280                 285             


Asn Glu Lys Val Asn Asn Ala Leu Arg Val Gly Asp His Gly Thr Thr 
    290                 295                 300                 


Tyr Gly Gly Asn Pro Leu Ala Cys Ser Val Ser Asn Tyr Val Leu Asp 
305                 310                 315                 320 


Thr Ile Ala Asp Glu Ala Phe Leu Lys Gln Val Ser Lys Lys Ser Asp 
                325                 330                 335     


Ile Leu Gln Lys Arg Leu Arg Glu Ile Gln Ala Lys Tyr Pro Asn Gln 
            340                 345                 350         


Ile Lys Thr Ile Arg Gly Lys Gly Leu Met Leu Gly Ala Glu Phe Val 
        355                 360                 365             


Glu Pro Pro Thr Glu Val Ile Lys Lys Ala Arg Glu Leu Gly Leu Leu 
    370                 375                 380                 


Ile Ile Thr Ala Gly Lys Ser Thr Val Arg Phe Val Pro Ala Leu Thr 
385                 390                 395                 400 


Ile Glu Asp Glu Leu Ile Glu Glu Gly Met Asp Ala Phe Glu Lys Ala 
                405                 410                 415     


Ile Glu Ala Val Tyr Ala 
            420         


<210>  82
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  82
gcggccgcta tatattatgt attattatat aaatatatat atatattata ttataagtaa       60

taataagtat tatattatat atagctttta tagcttagtg gtaaagcgat aaattgaaga      120

tttatttaca tgtagttcga ttctcattaa gggcaatagc tatttttagt ggtatggcgt      180

tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg      240

caccgagtcg gtgctaggag attagcttaa ttggtatagc attcgtttta cacacgaaag      300

attataggtt cgaaccctat atttcctaaa tccatgtaaa tattgtgaac cgttttagag      360

ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag tggcaccgag      420

tcggtgctga gcttgtatag tttaattggt taaaacattt gtctcataaa taaataatgt      480

aaggttcaat tccttctaca agtattatta ataattaaca ataattaata tattataatt      540

tatatatata tattttatat tattataata atattcttac aaatataatt attatatatt      600

attccttcaa aactcctaac ggcaccatgg                                       630


<210>  83
<211>  300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  83
tctagatcaa atatataagt aataggggga gggggtgggt gataataacc agaatattaa       60

ataaatacag agcacacatt tgttaatatt taataatata atcaataaat atattataat      120

aatataatat aattaataat agatataaag tataaacaat ataataaatt atataaaata      180

aatataaatt aaaaataata accaaataat taatataata aatgataaac aagaagatat      240

ccgggtccca ataataatta ttattgaaaa taataattgg gacccccaca atgcggccgc      300


<210>  84
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  84
gaaaagtgcc acctgggtcc ttttcatcac g                                      31


<210>  85
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  85
gacgaaaggg cctcgtgata cgcctat                                           27


<210>  86
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Right Junction

<400>  86
cacattcagg acctagtgta gatttagcaa tttttgcatt acatttaaca tcaatttcat       60

cattattagg tgctattaat ttcattgtaa caacattaaa tatgagaaca aatggtatga      120

caatgcataa attaccatta tttgtatgat caattttcat tacagcgttc ttattattat      180

tatcattacc tgtattatct gctggtatta caatgttatt attagataga aacttcaata      240

cttcattttt cggagtttct ggtggaggtg gtggaatgac acatttagaa agaagtagac      300

aaatgtcaaa aggtgaagaa ttattcactg gagtagtacc tatcttagta gaattagatg      360

gtgatgtaaa tggtcataaa ttctcagtat caggtaaagg tgaaggtgat gctacatatg      420

gtaaattaac attaaaattc atctgtacaa caggtaaatt acctgtacct t               471


<210>  87
<211>  713
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Left Junction

<400>  87
gaggttacgt acaagaaaga acaatcttct tcaaagatga tggtaattat aaaacaagag       60

ctgaagtaaa attcgaaggt gatacattag taaatagaat cgagttaaaa ggtatcgatt      120

tcaaagaaga tggtaatatc ttaggtcata aattagaata taattataat tcacataatg      180

tatatatcat ggctgataaa caaaaaaatg gtatcaaagt aaatttcaaa atcagacata      240

atatcgaaga cggttcagta caattagcag atcattatca acaaaataca cctatcggtg      300

atggtcctgt attattacct gataatcatt acttaagtac acaatcagct ttatcaaaag      360

atcctaatga aaaaagagat catatggtat tattagaatt tgtaacagct gctggtatca      420

cacatggtat ggatgaatta tataaataac aacaggaatt aaaattttct catgattaat      480

aaatcccttt agcaaggata aaaataaaaa taaaaataaa aagttgatca gaaattatca      540

aaaaataaat aataataata taataaaaac atatttaaat aataataata taattataat      600

aaatatatat aaaggtaatt tatatgatat ttatccaaga tcaaatagaa attatattca      660

accaaataat attaataaag aattagtagt atatggttat aatttagaat ctt             713


