                         SEQUENCE LISTING

<110>  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120>  NOVEL APPROACH FOR INCREASING CONTRACTILITY IN PATIENTS WITH 
       SYSTOLIC HEART FAILURE

<130>  36433PCT

<140>  PCT/US2020/040695
<141>  2020-07-02

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1

Lys Leu Met Gly Ser 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  2

Lys Leu Met Gly Ala 
1               5   


<210>  3
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Lys Lys Gln Gly Ser Thr Thr 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  4

Lys Lys Gln Gly Ala Ala Ala 
1               5           


<210>  5
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Arg Arg Ala Cys Ile Ser 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  6

Arg Arg Ala Cys Ile Ala 
1               5       


<210>  7
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Arg Asn Met Ser 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  8

Arg Asn Met Ala 
1               


<210>  9
<211>  8
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  9

Arg Ile Ser Lys Ser Lys Phe Ser 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  10

Arg Ile Ala Lys Ala Lys Phe Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  11

Lys Lys Leu Ala Arg Thr Ala Ser 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  12

Lys Lys Leu Ala Arg Ala Ala Ala 
1               5               


<210>  13
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  13

Lys Ser Ile Thr 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  14

Lys Ser Ile Ala 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  15

Arg Pro Leu Ser 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  16

Arg Pro Leu Ala 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  17

Arg Asp Trp Ser 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  18

Arg Asp Trp Ala 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  19

Arg Leu Val Ser 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  20

Arg Leu Val Ala 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  21

Arg Ile Lys Thr 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  22

Arg Ile Lys Ala 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  23

Lys Arg Thr Ser 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  24

Lys Arg Ala Ala 
1               


<210>  25
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Arg Asn Ala Leu Ser 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  26

Arg Asn Ala Leu Ala 
1               5   


<210>  27
<211>  9
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Arg Arg Ala Ile Ser Gly Asp Leu Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  28

Arg Arg Ala Ile Ala Gly Asp Leu Ala 
1               5                   


<210>  29
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  29

Lys Glu Ala Val Ser 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  30

Lys Glu Ala Val Ala 
1               5   


<210>  31
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  31

Lys Leu Val Asp Ser Thr 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  32

Lys Leu Val Asp Ala Ala 
1               5       


<210>  33
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  33

Lys Leu Ser Ser 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  34

Lys Leu Ala Ala 
1               


<210>  35
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  35

Lys Arg Cys His Ser 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  36

Lys Arg Cys His Ala 
1               5   


<210>  37
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  37

Arg Ser Ala Ser 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  38

Arg Ala Ala Ala 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  39

Arg Arg Ala Ser 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  40

Arg Arg Ala Ala 
1               


<210>  41
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  41

Arg Ser His Ser Pro Ser Ser 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  42

Arg Ala His Ala Pro Ala Ala 
1               5           


<210>  43
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  43

Lys Leu Asn Ser Ser 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  44

Lys Leu Asn Ala Ala 
1               5   


<210>  45
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  45

His Cys Gly Ser 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  46

His Cys Gly Ala 
1               


<210>  47
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  47

Arg Gly Asp Ser Ser 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  48

Arg Gly Asp Ala Ala 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  49

Arg Pro Val Ser Leu Thr 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  50

Arg Pro Val Ala Leu Ala 
1               5       


<210>  51
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  51

Phe His Gly Ser 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  52

Phe His Gly Ala 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  53

Lys Ala Lys Thr 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  54

Lys Ala Lys Ala 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  55

Lys Phe Tyr Ser 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  56

Lys Phe Tyr Ala 
1               


<210>  57
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  57

Lys Ser Gly Gly Asn Ser 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  58

Lys Ser Gly Gly Asn Ala 
1               5       


<210>  59
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  59

Arg Lys Ser Thr 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  60

Arg Lys Ala Ala 
1               


<210>  61
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Ser Asn Thr 
1               


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  62

Arg Ser Asn Ala 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  63

Lys Ile Ser Ser 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  64

Lys Ile Ala Ala 
1               


<210>  65
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg Gly Lys Ser 
1               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  66

Arg Gly Lys Ala 
1               


<210>  67
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Ser Ala Ser 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  68

Arg Ser Ala Ala 
1               


<210>  69
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  69

Arg Ser Ser Ser Ser 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  70

Arg Ala Ala Ala Ala 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  71

His Arg Ser Gly Thr 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  72

His Arg Ala Gly Ala 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  73

Arg Gly Leu Ser Arg 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  74

Arg Gly Leu Ala Arg 
1               5   


<210>  75
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  75

Arg Gln Glu Thr 
1               


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  76

Arg Gln Glu Ala 
1               


<210>  77
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Asp Glu Thr 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  78

Arg Asp Glu Ala 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  79

His Gly Ser Ser 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  80

His Gly Ala Ala 
1               


<210>  81
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  81

Arg Glu Ser Arg His Arg Ser 
1               5           


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  82

Arg Glu Ala Arg His Arg Ala 
1               5           


<210>  83
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  83

Lys Gln Arg Ser 
1               


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  84

Lys Gln Arg Ala 
1               


<210>  85
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg His Lys Ser 
1               


<210>  86
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALA Mutant

<400>  86

Arg His Lys Ala 
1               


<210>  87
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Thr Leu Asn Gly Gly Ser Gly Ala Ser Gly Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Glu Arg Asp Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala Pro 
            20                  25                  30          


Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln Ala 
        35                  40                  45              


Ala Leu Ala Pro Gly Ser Leu Ala Thr Thr Ala Ala Gly Thr Arg Thr 
    50                  55                  60                  


Gln Gly Gln Arg Leu Asp Trp Pro Glu Gly Ser Ser Asp Ser Leu Ser 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Ser Glu Glu Gly Val Tyr Lys Val Leu Leu Leu 
                85                  90                  95      


Gly Ala Pro Gly Val Gly Lys Ser Ala Leu Ala Arg Ile Phe Gly Gly 
            100                 105                 110         


Ile Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His Thr Tyr Asp Arg 
        115                 120                 125             


Ser Ile Thr Val Asp Gly Glu Glu Ala Ser Leu Leu Val Tyr Asp Ile 
    130                 135                 140                 


Trp Glu Gln Asp Gly Gly Cys Trp Leu Pro Gly His Cys Met Ala Met 
145                 150                 155                 160 


Gly Asp Ala Tyr Val Ile Val Tyr Ser Ile Thr Asp Lys Gly Ser Phe 
                165                 170                 175     


Glu Lys Ala Ser Glu Leu Arg Val Gln Leu Arg Arg Ala Arg Gln Thr 
            180                 185                 190         


Asp Asp Val Pro Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val Arg 
        195                 200                 205             


Ser Arg Glu Val Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val Phe 
    210                 215                 220                 


Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His His Asn Val Gln 
225                 230                 235                 240 


Ala Leu Phe Glu Gly Val Val Arg Gln Ile Arg Leu Arg Arg Asp Ser 
                245                 250                 255     


Lys Glu Asp Asn Ala Arg Arg Gln Ala Gly Thr Arg Arg Arg Glu Ser 
            260                 265                 270         


Leu Gly Lys Lys Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Arg Asn 
        275                 280                 285             


Ser Arg Lys Met Ala Phe Arg Ala Lys Ser Lys Ser Cys His Asp Leu 
    290                 295                 300                 


Ser Val Leu 
305         


<210>  88
<211>  308
<212>  PRT
<213>  Mus musculus

<400>  88

Met Thr Leu Asn Gly Gly Ser Gly Ala Ser Gly Ser Arg Gly Ala Gly 
1               5                   10                  15      


Gly Arg Glu Arg Asp Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala 
            20                  25                  30          


Pro Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln 
        35                  40                  45              


Ala Ala Leu Ala Pro Gly Ser Leu Ala Thr Thr Ala Ala Gly Thr Arg 
    50                  55                  60                  


Thr Gln Gly Gln Arg Leu Asp Trp Pro Glu Gly Ser Ser Asp Ser Leu 
65                  70                  75                  80  


Ser Ser Gly Gly Ser Gly Ser Glu Glu Gly Val Tyr Lys Val Leu Leu 
                85                  90                  95      


Leu Gly Ala Pro Gly Val Gly Lys Ser Ala Leu Ala Arg Ile Phe Gly 
            100                 105                 110         


Gly Ile Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His Thr Tyr Asp 
        115                 120                 125             


Arg Ser Ile Thr Val Asp Gly Glu Glu Ala Ser Leu Leu Val Tyr Asp 
    130                 135                 140                 


Ile Trp Glu Glu Asp Gly Gly Cys Trp Leu Pro Gly His Cys Met Ala 
145                 150                 155                 160 


Met Gly Asp Ala Tyr Val Ile Val Tyr Ser Ile Thr Asp Lys Gly Ser 
                165                 170                 175     


Phe Glu Lys Ala Ser Glu Leu Arg Val Gln Leu Arg Arg Ala Arg Gln 
            180                 185                 190         


Thr Asp Asp Val Pro Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val 
        195                 200                 205             


Arg Ser Arg Glu Val Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val 
    210                 215                 220                 


Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His His Asn Val 
225                 230                 235                 240 


Gln Ala Leu Phe Glu Gly Val Val Arg Gln Ile Arg Leu Arg Arg Asp 
                245                 250                 255     


Ser Lys Glu Asp Asn Ala Arg Arg Gln Ala Gly Thr Arg Arg Arg Glu 
            260                 265                 270         


Ser Leu Gly Lys Lys Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Arg 
        275                 280                 285             


Asn Ser Arg Lys Met Ala Phe Arg Ala Lys Ser Lys Ser Cys His Asp 
    290                 295                 300                 


Leu Ser Val Leu 
305             


<210>  89
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Leu Asp Arg Arg Leu Ile Ala Pro Gln Thr Lys Tyr Ile Ile Pro 
1               5                   10                  15      


Gly Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
            20                  25                  30          


Ser Leu Glu Glu Asp Arg Glu Ala Val Arg Arg Glu Ala Glu Arg Gln 
        35                  40                  45              


Ala Gln Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala Phe Ala 
    50                  55                  60                  


Val Arg Thr Tyr Ser Ala Ala His Glu Asp Asp Val Pro Val Pro Gly 
65                  70                  75                  80  


Met Ala Ile Ser Phe Glu Ala Lys Asp Phe Leu His Val Lys Glu Lys 
                85                  90                  95      


Phe Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu 
            100                 105                 110         


Ile Gly Phe Ile Pro Ser Pro Val Lys Leu Glu Asn Met Arg Leu Gln 
        115                 120                 125             


His Glu Gln Arg Ala Lys Phe Tyr Ser Ser Lys Ser Gly Gly Asn Ser 
    130                 135                 140                 


Ser Ser Ser Leu Gly Asp Ile Val Pro Ser Ser Arg Lys Ser Thr Pro 
145                 150                 155                 160 


Pro Ser Ser Ala Ile Asp Ile Asp Ala Thr Gly Leu Asp Ala Glu Glu 
                165                 170                 175     


Asn Asp Ile Pro Ala Asn His Arg Ser Pro Lys Pro Ser Ala Asn Ser 
            180                 185                 190         


Val Thr Ser Pro His Ser Lys Glu Lys Phe Phe Lys Lys Thr Glu His 
        195                 200                 205             


Thr Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val 
    210                 215                 220                 


Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala 
225                 230                 235                 240 


Leu Phe Asp Phe Leu Lys His Arg Phe Glu Gly Arg Ile Ser Ile Thr 
                245                 250                 255     


Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Asn Pro Ser Lys 
            260                 265                 270         


His Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val 
        275                 280                 285             


Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu 
    290                 295                 300                 


Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys 
305                 310                 315                 320 


Thr Ser Leu Ala Pro Ile Ile Val Tyr Val Lys Ile Ser Ser Pro Gln 
                325                 330                 335     


Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ala Lys His Leu Asn Val 
            340                 345                 350         


Gln Met Val Ala Ala Asp Lys Leu Ala Gln Cys Pro Pro Glu Leu Phe 
        355                 360                 365             


Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu 
    370                 375                 380                 


Ala Asp Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser 
385                 390                 395                 400 


Ser Leu Leu Leu Ser Arg Thr Leu Ala Thr Ser Ser Leu Pro Leu Ser 
                405                 410                 415     


Pro Thr Leu Ala Ser Asn Ser Gln Gly Ser Gln Gly Asp Gln Arg Thr 
            420                 425                 430         


Asp Arg Ser Ala Pro Ile Arg Ser Ala Ser Gln Ala Glu Glu Glu Pro 
        435                 440                 445             


Ser Val Glu Pro Val Lys Lys Ser Gln His Arg Ser Ser Ser Ser Ala 
    450                 455                 460                 


Pro His His Asn His Thr Ser Arg Gly Leu Ser Arg Gln Glu Thr Phe 
465                 470                 475                 480 


Asp Ser Glu Thr Gln Glu Ser Arg Asp Ser Ala Tyr Val Glu Pro Lys 
                485                 490                 495     


Glu Asp Tyr Ser His Asp His Val Asp His Tyr Ala Ser His Arg Asp 
            500                 505                 510         


His Asn His Arg Asp Glu Thr His Gly Ser Ser Asp His Arg His Arg 
        515                 520                 525             


Glu Ser Arg His Arg Ser Arg Asp Glu Gln Asp His Asn Glu Cys Asn 
    530                 535                 540                 


Lys Gln Arg Ser Arg His Lys Ser Lys Asp Arg Tyr Cys Glu Lys Asp 
545                 550                 555                 560 


Gly Glu Val Ile Ser Lys Lys Arg Asn Glu Ala Gly Glu Trp Asn Arg 
                565                 570                 575     


Asp Val Tyr Ile Pro Gln 
            580         


<210>  90
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  90

Met Thr Leu Asn Gly Gly Ser Gly Ala Ser Gly Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Glu Arg Asp Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala Pro 
            20                  25                  30          


Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln Ala 
        35                  40                  45              


Ala Leu Ala Pro Gly Ser Leu Ala Thr Thr Ala Ala Gly Thr Arg Thr 
    50                  55                  60                  


Gln Gly Gln Arg Leu Asp Trp Pro Glu Gly Ser Ser Asp Ser Leu Ser 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Ser Glu Glu Gly Val Tyr Lys Val Leu Leu Gly 
                85                  90                  95      


Ala Pro Gly Val Gly Lys Ser Ala Leu Ala Arg Ile Phe Gly Gly Ile 
            100                 105                 110         


Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His Thr Tyr Asp Arg Ser 
        115                 120                 125             


Ile Thr Val Asp Gly Glu Glu Ala Ser Leu Leu Val Tyr Asp Ile Trp 
    130                 135                 140                 


Glu Gln Asp Gly Gly Cys Trp Leu Pro Gly His Cys Met Ala Met Gly 
145                 150                 155                 160 


Asp Ala Tyr Val Ile Val Tyr Ser Ile Thr Asp Lys Gly Ser Phe Glu 
                165                 170                 175     


Lys Ala Ser Glu Leu Arg Val Gln Leu Arg Arg Ala Arg Gln Thr Asp 
            180                 185                 190         


Asp Val Pro Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val Arg Ser 
        195                 200                 205             


Arg Glu Val Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val Phe Asp 
    210                 215                 220                 


Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His His Asn Val Gln Ala 
225                 230                 235                 240 


Leu Phe Glu Gly Val Val Arg Gln Ile Arg Leu Arg Arg Asp Ser Lys 
                245                 250                 255     


Glu Asp Asn Ala Arg Arg Gln Ala Gly Thr Arg Arg Arg Glu Ser Leu 
            260                 265                 270         


Gly Lys Lys Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Arg Asn Ser 
        275                 280                 285             


Arg Lys Met Ala Phe Arg Ala Lys Ser Lys Ser Cys His Asp Leu Ser 
    290                 295                 300                 


Val Leu 
305     


<210>  91
<211>  296
<212>  PRT
<213>  Mus musculus

<400>  91

Met Thr Leu Asn Thr Gln Gln Glu Ala Lys Thr Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ala Ser Thr Pro Leu Pro Leu Ser Ser Arg Gly His Gln Pro Gly Arg 
            20                  25                  30          


Leu Cys Thr Ala Pro Ser Ala Pro Ser Gln His Pro Arg Leu Gly Gln 
        35                  40                  45              


Ser Val Ser Leu Asn Pro Pro Val Arg Lys Pro Ser Pro Ala Gln Asp 
    50                  55                  60                  


Gly Trp Ser Ser Glu Ser Ser Asp Ser Glu Gly Ser Trp Glu Ala Leu 
65                  70                  75                  80  


Tyr Arg Val Val Leu Leu Gly Asp Pro Gly Val Gly Lys Thr Ser Leu 
                85                  90                  95      


Ala Ser Leu Phe Ala Glu Lys Gln Asp Arg Asp Pro His Glu Gln Leu 
            100                 105                 110         


Gly Gly Val Tyr Glu Arg Thr Leu Ser Val Asp Gly Glu Asp Thr Thr 
        115                 120                 125             


Leu Val Val Met Asp Thr Trp Glu Ala Glu Lys Leu Asp Glu Ser Trp 
    130                 135                 140                 


Cys Gln Glu Ser Cys Leu Gln Ala Gly Ser Ala Tyr Val Ile Val Tyr 
145                 150                 155                 160 


Ser Ile Ala Asp Arg Ser Ser Phe Glu Ser Ala Ser Glu Leu Arg Ile 
                165                 170                 175     


Gln Leu Arg Arg Thr His Gln Ala Asn His Val Pro Ile Ile Leu Val 
            180                 185                 190         


Gly Asn Lys Ala Asp Leu Ala Arg Arg Glu Val Ser Val Glu Glu Gly 
        195                 200                 205             


Arg Ala Cys Ala Val Val Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala 
    210                 215                 220                 


Thr Leu Gln His Asn Val Thr Glu Leu Phe Glu Gly Val Val Arg Gln 
225                 230                 235                 240 


Leu Arg Leu Arg Arg Gln Asp Asn Ala Ala Pro Glu Thr Pro Ser Pro 
                245                 250                 255     


Arg Arg Arg Ala Ser Leu Gly Gln Arg Ala Arg Arg Phe Leu Ala Arg 
            260                 265                 270         


Leu Thr Ala Arg Ser Ala Arg Arg Arg Ala Leu Lys Ala Arg Ser Lys 
        275                 280                 285             


Ser Cys His Asn Leu Ala Val Leu 
    290                 295     


<210>  92
<211>  340
<212>  PRT
<213>  Mus musculus

<400>  92

Met His Thr Asp Leu Asp Thr Asp Met Asp Met Asp Thr Glu Thr Val 
1               5                   10                  15      


Ala Leu Cys Ser Ser Ser Ser Arg Gln Ala Ser Pro Leu Gly Thr Pro 
            20                  25                  30          


Thr Pro Glu Ala Asp Thr Thr Leu Leu Lys Gln Lys Pro Glu Lys Leu 
        35                  40                  45              


Leu Ala Glu Leu Asp Leu Ser Gly Pro Pro Pro Ala Pro Gly Val Pro 
    50                  55                  60                  


Arg Arg Arg Gly Ser Met Pro Val Pro Tyr Lys His Gln Leu Arg Arg 
65                  70                  75                  80  


Ala Gln Ala Val Asp Glu Leu Asp Trp Pro Pro Gln Ala Ser Pro Ser 
                85                  90                  95      


Gly Ser Ser Asp Ser Leu Gly Ser Gly Glu Ala Ala Leu Thr Gln Lys 
            100                 105                 110         


Asp Gly Val Phe Lys Val Met Leu Val Gly Glu Ser Gly Val Gly Lys 
        115                 120                 125             


Ser Thr Leu Ala Gly Thr Phe Gly Gly Leu Gln Gly Asp His Ala His 
    130                 135                 140                 


Glu Met Glu Asn Ser Glu Asp Thr Tyr Glu Arg Arg Ile Met Val Asp 
145                 150                 155                 160 


Lys Glu Glu Val Thr Leu Ile Val Tyr Asp Ile Trp Glu Gln Gly Asp 
                165                 170                 175     


Ala Gly Gly Trp Leu Gln Asp His Cys Leu Gln Thr Gly Asp Ala Phe 
            180                 185                 190         


Leu Ile Val Phe Ser Val Thr Asp Arg Arg Ser Phe Ser Lys Val Pro 
        195                 200                 205             


Glu Thr Leu Leu Arg Leu Arg Ala Gly Arg Pro His His Asp Leu Pro 
    210                 215                 220                 


Val Ile Leu Val Gly Asn Lys Ser Asp Leu Ala Arg Arg Glu Val Ser 
225                 230                 235                 240 


Leu Glu Glu Gly Arg His Leu Ala Gly Thr Leu Ser Cys Lys His Ile 
                245                 250                 255     


Glu Thr Ser Ala Ala Leu His His Asn Thr Arg Glu Leu Phe Glu Gly 
            260                 265                 270         


Ala Val Arg Gln Ile Arg Leu Arg Arg Gly Arg Gly His Ala Gly Gly 
        275                 280                 285             


Gln Arg Pro Glu Pro Ser Ser Pro Asp Gly Pro Ala Pro Pro Thr Arg 
    290                 295                 300                 


Arg Glu Ser Leu Thr Lys Lys Ala Lys Arg Phe Leu Ala Asn Leu Val 
305                 310                 315                 320 


Pro Arg Asn Ala Lys Phe Phe Lys Gln Arg Ser Arg Ser Cys His Asp 
                325                 330                 335     


Leu Ser Val Leu 
            340 


<210>  93
<211>  295
<212>  PRT
<213>  Mus musculus

<400>  93

Met Thr Leu Asn Asn Val Thr Met Arg Gln Gly Thr Val Gly Met Gln 
1               5                   10                  15      


Pro Gln Gln Arg Trp Ser Met Pro Ala Asp Ala Arg His Leu Met Val 
            20                  25                  30          


Gln Lys Asp Pro His Pro Cys Asn Leu Arg Asn Arg His Ser Thr Ala 
        35                  40                  45              


Pro Glu Glu His Cys Arg Arg Thr Trp Ser Ser Asp Ser Thr Asp Ser 
    50                  55                  60                  


Val Ile Ser Ser Glu Ser Gly Asn Thr Tyr Tyr Arg Val Val Leu Ile 
65                  70                  75                  80  


Gly Glu Gln Gly Val Gly Lys Ser Thr Leu Ala Asn Ile Phe Ala Gly 
                85                  90                  95      


Val His Asp Ser Met Asp Ser Asp Cys Glu Val Leu Gly Glu Asp Thr 
            100                 105                 110         


Tyr Glu Arg Thr Leu Val Val Asp Gly Glu Ser Ala Thr Ile Ile Leu 
        115                 120                 125             


Leu Asp Met Trp Glu Asn Lys Gly Glu Asn Glu Trp Leu His Asp His 
    130                 135                 140                 


Cys Met Gln Val Gly Asp Ala Tyr Leu Ile Val Tyr Ser Ile Thr Asp 
145                 150                 155                 160 


Arg Ala Ser Phe Glu Lys Ala Ser Glu Leu Arg Ile Gln Leu Arg Arg 
                165                 170                 175     


Ala Arg Gln Thr Glu Asp Ile Pro Ile Ile Leu Val Gly Asn Lys Ser 
            180                 185                 190         


Asp Leu Val Arg Cys Arg Glu Val Ser Val Ser Glu Gly Arg Ala Cys 
        195                 200                 205             


Ala Val Val Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Val Gln 
    210                 215                 220                 


His Asn Val Lys Glu Leu Phe Glu Gly Ile Glu Arg Gln Val Arg Leu 
225                 230                 235                 240 


Pro Arg Asp Ser Lys Glu Lys Asn Glu Arg Arg Leu Ala Tyr Gln Lys 
                245                 250                 255     


Arg Arg Glu Ser Ile Pro Arg Lys Ala Arg Arg Phe Trp Gly Lys Ile 
            260                 265                 270         


Val Ala Lys Asn Asn Lys Asn Met Ala Ser Ser Ser Lys Ser Lys Ser 
        275                 280                 285             


Cys His Asp Leu Ser Val Leu 
    290                 295 


<210>  94
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence of Mouse Rrad, Mouse Rem1, Mouse Rem2, and 
       Mouse Gem sequences

<400>  94

Met His Thr Asp Leu Asp Thr Asp Met Thr Leu Asn Ala Pro Ser Leu 
1               5                   10                  15      


Ala Pro Arg Arg Ala Gln Ala Val Asp Glu Trp Pro Pro Gln Ala Ser 
            20                  25                  30          


Ser Asp Ser Ser Gly Gln Glu Tyr Val Gly Gly Val Gly Lys Ser Leu 
        35                  40                  45              


Ala Phe Gly Asp Glu Gly Glu Thr Tyr Glu Arg Val Asp Gly Glu Thr 
    50                  55                  60                  


Leu Val Asp Trp Glu Ala Trp Leu His Cys Gln Gly Asp Ala Tyr Ile 
65                  70                  75                  80  


Val Tyr Ser Ile Thr Asp Arg Ser Phe Glu Lys Ala Ser Glu Leu Arg 
                85                  90                  95      


Gln Leu Arg Arg Arg Gln Asp Pro Ile Ile Leu Val Gly Asn Lys Ser 
            100                 105                 110         


Asp Leu Arg Glu Val Ser Val Glu Gly Arg Ala Cys Ala Val Val Phe 
        115                 120                 125             


Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His Asn Val Glu Leu 
    130                 135                 140                 


Phe Glu Gly Val Arg Gln Arg Leu Arg Arg Arg Pro Glu Pro Ser Ser 
145                 150                 155                 160 


Pro Asp Gly Ala Arg Arg Glu Ser Leu Lys Ala Arg Phe Leu Val Ala 
                165                 170                 175     


Arg Asn Met Ala Ser Lys Ser Cys His Asp Leu Ser Val Leu 
            180                 185                 190 


<210>  95
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  95

Ile Phe Gly Gly Ile Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His 
1               5                   10                  15      


Thr Tyr Asp Arg 
            20  


<210>  96
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Thr Leu Asn Gly Gly Gly Ser Gly Ala Gly Gly Ser Arg Gly Gly 
1               5                   10                  15      


Gly Gln Glu Arg Glu Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala 
            20                  25                  30          


Pro Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln 
        35                  40                  45              


Ala Ala Leu Thr Pro Gly Ala Leu Thr Ala Ala Ala Ala Gly Thr Gly 
    50                  55                  60                  


Thr Gln Gly Pro Arg Leu Asp Trp Pro Glu Asp Ser Glu Asp Ser Leu 
65                  70                  75                  80  


Ser Ser Gly Gly Ser Asp Ser Asp Glu Ser Val Tyr Lys Val Leu Leu 
                85                  90                  95      


Leu Gly Ala Pro Gly Val Gly Lys Ser Ala Leu Ala Arg Ile Phe Gly 
            100                 105                 110         


Gly Val Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His Thr Tyr Asp 
        115                 120                 125             


Arg Ser Ile Val Val Asp Gly Glu Glu Ala Ser Leu Met Val Tyr Asp 
    130                 135                 140                 


Ile Trp Glu Gln Asp Gly Gly Arg Trp Leu Pro Gly His Cys Met Ala 
145                 150                 155                 160 


Met Gly Asp Ala Tyr Val Ile Val Tyr Ser Val Thr Asp Lys Gly Ser 
                165                 170                 175     


Phe Glu Lys Ala Ser Glu Leu Arg Val Gln Leu Arg Arg Ala Arg Gln 
            180                 185                 190         


Thr Asp Asp Val Pro Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val 
        195                 200                 205             


Arg Ser Arg Glu Val Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val 
    210                 215                 220                 


Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His His Asn Val 
225                 230                 235                 240 


Gln Ala Leu Phe Glu Gly Val Val Arg Gln Ile Arg Leu Arg Arg Asp 
                245                 250                 255     


Ser Lys Glu Ala Asn Ala Arg Arg Gln Ala Gly Thr Arg Arg Arg Glu 
            260                 265                 270         


Ser Leu Gly Lys Lys Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Arg 
        275                 280                 285             


Asn Ser Arg Lys Met Ala Phe Arg Ala Lys Ser Lys Ser Cys His Asp 
    290                 295                 300                 


Leu Ser Val Leu 
305             


<210>  97
<211>  307
<212>  PRT
<213>  Rattus rattus

<400>  97

Met Thr Leu Asn Gly Gly Ser Gly Ala Gly Gly Ser Arg Ser Ala Gly 
1               5                   10                  15      


Arg Glu Arg Asp Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala Pro 
            20                  25                  30          


Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln Ala 
        35                  40                  45              


Ala Leu Thr Pro Gly Ser Leu Ala Ala Thr Ala Ala Gly Thr Arg Thr 
    50                  55                  60                  


Gln Gly Gln Arg Leu Asp Trp Pro Glu Gly Ser Ser Asp Ser Leu Ser 
65                  70                  75                  80  


Ser Gly Asp Ser Gly Ser Glu Asp Gly Val Tyr Lys Val Leu Leu Leu 
                85                  90                  95      


Gly Ala Pro Gly Val Gly Lys Ser Ala Leu Ala Arg Ile Phe Gly Gly 
            100                 105                 110         


Ile Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His Thr Tyr Asp Arg 
        115                 120                 125             


Ser Ile Thr Val Asp Gly Glu Glu Ala Ser Leu Met Val Tyr Asp Ile 
    130                 135                 140                 


Trp Glu Gln Asp Gly Gly Cys Trp Leu Pro Gly His Cys Met Ala Met 
145                 150                 155                 160 


Gly Asp Ala Tyr Val Ile Val Tyr Ser Ile Thr Asp Lys Gly Ser Phe 
                165                 170                 175     


Glu Lys Ala Ser Glu Leu Arg Val Gln Leu Arg Arg Ala Arg Gln Thr 
            180                 185                 190         


Asp Asn Val Pro Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val Arg 
        195                 200                 205             


Ser Arg Glu Val Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val Phe 
    210                 215                 220                 


Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His His Asn Val Gln 
225                 230                 235                 240 


Ala Leu Phe Glu Gly Val Val Arg Gln Ile Arg Leu Arg Arg Asp Ser 
                245                 250                 255     


Lys Glu Asp Asn Ala Arg Arg Gln Ala Gly Thr Arg Arg Arg Glu Ser 
            260                 265                 270         


Leu Gly Lys Lys Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Arg Asn 
        275                 280                 285             


Ser Arg Lys Met Ala Phe Arg Ala Lys Ser Lys Ser Cys His Asp Leu 
    290                 295                 300                 


Ser Val Leu 
305         


<210>  98
<211>  324
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  98

Met Leu Pro Ser Arg Phe Ser Val Pro Gln Thr Ala Ser Asp Ala Met 
1               5                   10                  15      


Thr Leu Asn Gly Gly Gly Gly Gly Gly Ala Gly Gly Ser Arg Gly Gly 
            20                  25                  30          


Gly Arg Glu Arg Glu Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala 
        35                  40                  45              


Pro Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln 
    50                  55                  60                  


Ala Ala Leu Ala Pro Gly Ala Leu Ala Ala Thr Ala Ala Gly Ala Ala 
65                  70                  75                  80  


Thr Gln Gly Pro Arg Leu Asp Trp Pro Glu Gly Ser Ser Asp Ser Leu 
                85                  90                  95      


Ser Ser Gly Gly Ser Ser Ser Asp Asp Ser Val Tyr Lys Val Leu Leu 
            100                 105                 110         


Leu Gly Ala Pro Gly Val Gly Lys Ser Ala Leu Ala Arg Ile Phe Gly 
        115                 120                 125             


Gly Val Glu Asp Gly Pro Glu Ala Glu Ala Ala Gly His Thr Tyr Asp 
    130                 135                 140                 


Arg Ser Ile Met Val Asp Gly Glu Glu Ala Ser Leu Met Val Tyr Asp 
145                 150                 155                 160 


Ile Trp Glu Gln Asp Gly Gly Arg Trp Leu Pro Gly His Cys Met Ala 
                165                 170                 175     


Met Gly Asp Ala Tyr Val Ile Val Tyr Ser Val Thr Asp Lys Gly Ser 
            180                 185                 190         


Phe Glu Lys Ala Ser Glu Leu Arg Val Gln Leu Arg Arg Ala Arg Gln 
        195                 200                 205             


Thr Asp Asp Val Pro Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val 
    210                 215                 220                 


Arg Ser Arg Glu Val Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val 
225                 230                 235                 240 


Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Leu His His Asn Val 
                245                 250                 255     


Gln Ala Leu Phe Glu Gly Ile Val Arg Gln Ile Arg Leu Arg Arg Asp 
            260                 265                 270         


Ser Lys Glu Ala Asn Ala Arg Arg Gln Ala Gly Ala Arg Arg Arg Glu 
        275                 280                 285             


Ser Leu Gly Lys Lys Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Arg 
    290                 295                 300                 


Asn Ser Arg Lys Met Ala Phe Arg Ala Lys Ser Lys Ser Cys His Asp 
305                 310                 315                 320 


Leu Ser Val Leu 
                


<210>  99
<211>  303
<212>  PRT
<213>  Gallus gallus

<400>  99

Met Thr Leu Asn Arg Gly Asp Lys Leu Arg Tyr Leu Asp Lys Arg Arg 
1               5                   10                  15      


Gly Ser Met Pro Phe Ser Ala His Gln His Leu His Arg Arg Ser Met 
            20                  25                  30          


Pro Val Asp Glu Arg Asp Leu Arg Ala Ser Leu Pro Gln Asp Glu Leu 
        35                  40                  45              


Ser Gly Leu Val Arg Cys Thr Ser Tyr Ser Pro Gly Glu Ala His Arg 
    50                  55                  60                  


Glu Ser Trp Ala Ser Asp Ser Ser Asp Ser Val Ile Ser Ser Gly Ser 
65                  70                  75                  80  


Asp Ser Asp Gly Ser Leu Tyr Lys Val Ile Leu Leu Gly Glu His Gly 
                85                  90                  95      


Val Gly Lys Thr Ser Leu Ala Arg Ile Phe Gly Gly Val Glu Asp Gly 
            100                 105                 110         


Ala Glu Ala Glu Glu Ala Gly Asn Thr Tyr Asp Arg Ser Ile Met Val 
        115                 120                 125             


Asp Gly Glu Glu Ala Ser Leu Val Val Phe Asp Ile Trp Glu Gln Asp 
    130                 135                 140                 


Asp Ser Gln Trp Leu Gln Asn His Cys Met Lys Met Gly Asp Ala Tyr 
145                 150                 155                 160 


Val Ile Val Tyr Ser Val Thr Asp Lys Val Ser Phe Glu Lys Ala Ser 
                165                 170                 175     


Glu Leu Arg Ile Gln Leu Arg Arg Ala Arg Gln Thr Glu Asp Ile Pro 
            180                 185                 190         


Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val Arg Ser Arg Glu Val 
        195                 200                 205             


Ser Val Asp Glu Gly Arg Ala Cys Ala Val Val Phe Asp Cys Lys Phe 
    210                 215                 220                 


Ile Glu Thr Ser Ala Ala Leu His His Asn Val Lys Asp Leu Phe Glu 
225                 230                 235                 240 


Gly Ile Val Arg Gln Ile Arg Leu Arg Lys Asp Ser Lys Glu Asp Asn 
                245                 250                 255     


Ala Arg Arg Met Ala Asn Thr Lys Arg Arg Glu Ser Ile Gly Lys Lys 
            260                 265                 270         


Ala Lys Arg Phe Leu Gly Arg Ile Val Ala Lys Asn Asn Lys Lys Met 
        275                 280                 285             


Ala Phe Lys Ala Lys Ser Lys Ser Cys His Asp Leu Ser Val Leu 
    290                 295                 300             


<210>  100
<211>  300
<212>  PRT
<213>  Unknown

<220>
<223>  Genus Danio rrad

<400>  100

Met Thr Leu Asn Lys Gly Asp Lys Leu Arg Asn Met Asp Lys Arg Arg 
1               5                   10                  15      


Gly Ser Met Pro Phe Pro Leu His Leu Gln Thr Leu His Arg Arg Ser 
            20                  25                  30          


Met Pro Val Asp Asp Arg Glu Leu Arg Ser Met Pro Ala Ala Gln Pro 
        35                  40                  45              


Ser Glu Leu Pro Gly Leu Met Arg Phe Asn Ala Asp Arg Asn Ser Cys 
    50                  55                  60                  


Val Ser Asp Ser Ser Asp Ser Val Ile Ser Ser Gly Ser Asp Ser Asp 
65                  70                  75                  80  


Gly Gln Val Tyr Lys Val Val Leu Leu Gly Glu His Gly Val Gly Lys 
                85                  90                  95      


Ser Ser Leu Ala Arg Ile Phe Gly Gly Val Glu Asp Ser Asn Asp Cys 
            100                 105                 110         


Glu Glu Thr Gly Asn Thr Tyr Asp Arg Ser Leu Val Val Asp Asp Glu 
        115                 120                 125             


Glu Thr Ser Ile Leu Leu Tyr Asp Ile Trp Glu Gln Asp Asn Ser Gln 
    130                 135                 140                 


Trp Leu Gln Asp Gln Cys Met Arg Met Gly Asp Ala Tyr Ile Ile Val 
145                 150                 155                 160 


Tyr Ser Val Thr Asp Lys Ser Ser Phe Glu Lys Ala Ser Glu Leu Arg 
                165                 170                 175     


Ile Gln Leu Arg Arg Ala Arg Gln Ser Glu Asn Ile Pro Ile Ile Leu 
            180                 185                 190         


Val Gly Asn Lys Ser Asp Leu Val Arg Ser Arg Glu Val Ser Met Asp 
        195                 200                 205             


Glu Gly Ser Ala Cys Ala Val Val Phe Asp Cys Lys Phe Ile Glu Thr 
    210                 215                 220                 


Ser Ala Ser Leu His His Asn Val Arg Asp Leu Phe Glu Gly Ile Val 
225                 230                 235                 240 


Arg Gln Ile Arg Leu Arg Lys Asp Ser Lys Glu Glu Asn Ala Arg Arg 
                245                 250                 255     


Met Ala Asn Cys Lys Arg Arg Glu Ser Ile Ser Lys Lys Ala Lys Arg 
            260                 265                 270         


Phe Leu Gly Arg Met Val Ala Arg Lys Asn Lys Lys Met Ala Phe Arg 
        275                 280                 285             


Gln Lys Ser Lys Ser Cys His Asp Leu Ser Val Leu 
    290                 295                 300 


<210>  101
<211>  303
<212>  PRT
<213>  Xenopus laevis

<400>  101

Met Thr Leu Asn Arg Ser Asp Arg Val Lys Asn Met Glu Lys Arg Arg 
1               5                   10                  15      


Gly Ser Met Pro Phe Ser Met His Gln Gln Leu His Arg Arg Ser Met 
            20                  25                  30          


Pro Val Asp Asp Lys Glu Leu Gln Gly Lys Ala Pro Ala Ser Gln Leu 
        35                  40                  45              


Ser Ser Leu Leu Arg Cys Pro Ser Tyr Asn Pro Ser Gly Glu His Arg 
    50                  55                  60                  


Glu Ser Trp Ala Ser Asp Ser Ser Asp Ser Val Ile Ser Ser Gly Ser 
65                  70                  75                  80  


Asp Ser Glu Asp His Val Phe Lys Val Ile Leu Leu Gly Glu His Gly 
                85                  90                  95      


Val Gly Lys Ser Ser Leu Ala Arg Ile Phe Gly Gly Val Glu Asp Leu 
            100                 105                 110         


His Asp Val Glu Glu Ala Gly Asn Thr Tyr Asp Arg Ser Ile Val Val 
        115                 120                 125             


Asp Gly Glu Glu Ala Cys Leu Leu Val Phe Asp Ile Trp Glu Gln Asp 
    130                 135                 140                 


Asp Asn His Trp Leu His Asn Gln Cys Met Lys Met Gly Asp Ala Tyr 
145                 150                 155                 160 


Val Ile Val Tyr Ser Val Thr Asp Lys Ser Ser Phe Glu Lys Ala Ser 
                165                 170                 175     


Glu Leu Arg Ile Gln Leu Arg Arg Ala Arg Gln Ser Glu Asp Ile Pro 
            180                 185                 190         


Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Val Arg Ser Arg Glu Val 
        195                 200                 205             


Ser Val Glu Glu Gly Arg Ala Cys Ala Val Val Phe Asp Cys Lys Phe 
    210                 215                 220                 


Ile Glu Thr Ser Ala Ser Leu His His Asn Val Lys Asp Leu Phe Glu 
225                 230                 235                 240 


Gly Ile Val Arg Gln Val Arg Leu Arg Lys Asp Ser Lys Glu Asp Asn 
                245                 250                 255     


Ala Arg Arg Met Ala Ser Ser Lys Arg Arg Glu Ser Ile Gly Lys Lys 
            260                 265                 270         


Ala Lys Arg Phe Leu Gly Lys Ile Val Ala Lys Asn Asn Lys Lys Met 
        275                 280                 285             


Ala Phe Lys Gln Lys Ser Lys Ser Cys His Asp Leu Ser Val Leu 
    290                 295                 300             


<210>  102
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rrad Consensus Sequence

<400>  102

Met Leu Pro Ser Arg Phe Ser Val Pro Gln Thr Ala Ser Asp Ala Met 
1               5                   10                  15      


Thr Leu Asn Gly Gly Gly Gly Ser Gly Ala Gly Gly Ser Arg Gly Arg 
            20                  25                  30          


Glu Arg Asp Arg Arg Arg Gly Ser Thr Pro Trp Gly Pro Ala Leu Pro 
        35                  40                  45              


Pro Leu His Arg Arg Ser Met Pro Val Asp Glu Arg Asp Leu Gln Ala 
    50                  55                  60                  


Met Pro Ala Leu Pro Gly Leu Ala Ala Gly Ser Tyr Thr Gln Gly Arg 
65                  70                  75                  80  


Leu Asp Trp Pro Glu Asp Ser Ser Asp Ser Leu Ser Ser Gly Gly Ser 
                85                  90                  95      


Asp Ser Asp Val Tyr Lys Val Leu Leu Leu Gly Ala Pro Gly Val Gly 
            100                 105                 110         


Lys Ser Ala Leu Ala Arg Ile Phe Gly Gly Val Glu Asp Gly Pro Glu 
        115                 120                 125             


Ala Glu Ala Ala Gly His Thr Tyr Asp Arg Ser Ile Val Asp Gly Glu 
    130                 135                 140                 


Glu Ala Ser Leu Val Tyr Asp Ile Trp Glu Gln Asp Gly Gly Trp Leu 
145                 150                 155                 160 


Pro Gly His Cys Met Ala Met Gly Asp Ala Tyr Val Ile Val Tyr Ser 
                165                 170                 175     


Val Thr Asp Lys Gly Ser Phe Glu Lys Ala Ser Glu Leu Arg Val Gln 
            180                 185                 190         


Leu Arg Arg Ala Arg Gln Thr Asp Asp Val Pro Ile Ile Leu Val Gly 
        195                 200                 205             


Asn Lys Ser Asp Leu Val Arg Ser Arg Glu Val Ser Val Asp Glu Gly 
    210                 215                 220                 


Arg Ala Cys Ala Val Val Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala 
225                 230                 235                 240 


Ala Leu His His Asn Val Gln Ala Leu Phe Glu Gly Ile Val Arg Gln 
                245                 250                 255     


Ile Arg Leu Arg Arg Asp Ser Lys Glu Asp Asn Ala Arg Arg Gln Ala 
            260                 265                 270         


Gly Thr Arg Arg Arg Glu Ser Leu Gly Lys Lys Ala Lys Arg Phe Leu 
        275                 280                 285             


Gly Arg Ile Val Ala Arg Asn Ser Arg Lys Met Ala Phe Arg Ala Lys 
    290                 295                 300                 


Ser Lys Ser Cys His Asp Leu Ser Val Leu 
305                 310                 


