                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
 
<120> METHODS AND COMPOSITIONS FOR TREATMENT OF PANCREATIC CANCER

<130> MSKCC.042.WO1

<140>
<141>

<150> 62/937,219
<151> 2019-11-18

<150> 62/868,976
<151> 2019-06-30

<160> 15    

<170> PatentIn version 3.5

<210> 1
<211> 159
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser 
1               5                   10                  15      


Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr 
            20                  25                  30          


Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val 
        35                  40                  45              


Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp 
    50                  55                  60                  


Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp 
65                  70                  75                  80  


Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys 
                85                  90                  95      


Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met 
            100                 105                 110         


His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe 
        115                 120                 125             


Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser 
    130                 135                 140                 


Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
145                 150                 155                 


<210> 2
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
1               5                   10                  15      


Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
            20                  25                  30          


Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
        35                  40                  45              


Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
    50                  55                  60                  


Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
65                  70                  75                  80  


Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
                85                  90                  95      


Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
            100                 105                 110         


Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
        115                 120                 125             


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
    130                 135                 140                 


Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
145                 150                 155                 160 


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      8xHis tag

<400> 3
His His His His His His His His 
1               5               


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 4
His His His His His His 
1               5       


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210> 6
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Gly Gly Gly 
1               


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210> 9
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230             


<210> 10
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ser His His His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Gly Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
            20                  25                  30          


Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
        35                  40                  45              


Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
    50                  55                  60                  


Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
65                  70                  75                  80  


Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
                85                  90                  95      


Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
            100                 105                 110         


Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
        115                 120                 125             


Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
    130                 135                 140                 


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
145                 150                 155                 160 


Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170                 175     


<210> 11
<211> 189
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Gly Gly Gly Gly Ser Ser Ile 
            20                  25                  30          


Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr 
        35                  40                  45              


Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile 
    50                  55                  60                  


Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu 
65                  70                  75                  80  


Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val 
                85                  90                  95      


Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp 
            100                 105                 110         


Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu 
        115                 120                 125             


Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser 
    130                 135                 140                 


Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly 
145                 150                 155                 160 


Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn 
                165                 170                 175     


Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            180                 185                 


<210> 12
<211> 421
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu 
            260                 265                 270         


Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala 
        275                 280                 285             


Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp 
    290                 295                 300                 


Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro 
305                 310                 315                 320 


Ser Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr 
                325                 330                 335     


Leu Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His 
            340                 345                 350         


Ser Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe 
        355                 360                 365             


Phe Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys 
    370                 375                 380                 


Thr Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu 
385                 390                 395                 400 


Ile Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe 
                405                 410                 415     


Lys Leu Ser Glu Thr 
            420     


<210> 13
<211> 534
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atgtcccacc atcaccatca ccaccaccac gaaaatctgt acttccaagg cagcatcacc       60

ggcatcagcc ccatcaccga gtatctggcc tctctgtcca cctacaacga ccagtccatc      120

acattcgctc tggaggacga aagctacgag atctacgtgg aggatctgaa gaaggacgag      180

aagaaggaca aggtgctgct gtcctactac gagtcccagc acccctccaa cgaaagcggc      240

gacggcgtgg atggcaagat gctgatggtg acactgagcc ccaccaagga cttttggctg      300

cacgccaaca acaaggagca cagcgtggag ctgcacaagt gcgagaaacc tctgcccgac      360

caagccttct tcgtgctgca caacatgcac agcaactgcg tgtccttcga gtgcaagacc      420

gaccccggcg tgttcatcgg cgtgaaggac aaccatctgg ctctgatcaa ggtggacagc      480

tccgagaacc tctgcaccga gaacattctg ttcaagctgt ccgagacctg atga            534


<210> 14
<211> 548
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
aagcttatgt cccaccatca ccatcaccac caccacgaaa atctgtactt ccaaggcagc       60

atcaccggca tcagccccat caccgagtat ctggcctctc tgtccaccta caacgaccag      120

tccatcacat tcgctctgga ggacgaaagc tacgagatct acgtggagga tctgaagaag      180

gacgagaaga aggacaaggt gctgctgtcc tactacgagt cccagcaccc ctccaacgaa      240

agcggcgacg gcgtggatgg caagatgctg atggtgacac tgagccccac caaggacttt      300

tggctgcacg ccaacaacaa ggagcacagc gtggagctgc acaagtgcga gaaacctctg      360

cccgaccaag ccttcttcgt gctgcacaac atgcacagca actgcgtgtc cttcgagtgc      420

aagaccgacc ccggcgtgtt catcggcgtg aaggacaacc atctggctct gatcaaggtg      480

gacagctccg agaacctctg caccgagaac attctgttca agctgtccga gacctgatga      540

gcggccgc                                                               548


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


