                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  Methods for Diagnosing Multiple Sclerosis

<130>  P62816WO

<150>  GB1909619.7
<151>  2019-07-04

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Glu Gly Gly Ser Ser Gly Gly Ala Ala Gly Thr Ser Ala 
1               5                   10                  15      


Asp Gly Gly Asp Gly Gly Glu Gln Leu Leu Thr Val Lys His Glu Leu 
            20                  25                  30          


Arg Thr Ala Asn Leu Thr Gly His Ala Glu Lys Val Gly Ile Glu Asn 
        35                  40                  45              


Phe Glu Leu Leu Lys Val Leu Gly Thr Gly Ala Tyr Gly Lys Val Phe 
    50                  55                  60                  


Leu Val Arg Lys Ile Ser Gly His Asp Thr Gly Lys Leu Tyr Ala Met 
65                  70                  75                  80  


Lys Val Leu Lys Lys Ala Thr Ile Val Gln Lys Ala Lys Thr Thr Glu 
                85                  90                  95      


His Thr Arg Thr Glu Arg Gln Val Leu Glu His Ile Arg Gln Ser Pro 
            100                 105                 110         


Phe Leu Val Thr Leu His Tyr Ala Phe Gln Thr Glu Thr Lys Leu His 
        115                 120                 125             


Leu Ile Leu Asp Tyr Ile Asn Gly Gly Glu Leu Phe Thr His Leu Ser 
    130                 135                 140                 


Gln Arg Glu Arg Phe Thr Glu His Glu Val Gln Ile Tyr Val Gly Glu 
145                 150                 155                 160 


Ile Val Leu Ala Leu Glu His Leu His Lys Leu Gly Ile Ile Tyr Arg 
                165                 170                 175     


Asp Ile Lys Leu Glu Asn Ile Leu Leu Asp Ser Asn Gly His Val Val 
            180                 185                 190         


Leu Thr Asp Phe Gly Leu Ser Lys Glu Phe Val Ala Asp Glu Thr Glu 
        195                 200                 205             


Arg Ala Tyr Ser Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Asp Ile 
    210                 215                 220                 


Val Arg Gly Gly Asp Ser Gly His Asp Lys Ala Val Asp Trp Trp Ser 
225                 230                 235                 240 


Leu Gly Val Leu Met Tyr Glu Leu Leu Thr Gly Ala Ser Pro Phe Thr 
                245                 250                 255     


Val Asp Gly Glu Lys Asn Ser Gln Ala Glu Ile Ser Arg Arg Ile Leu 
            260                 265                 270         


Lys Ser Glu Pro Pro Tyr Pro Gln Glu Met Ser Ala Leu Ala Lys Asp 
        275                 280                 285             


Leu Ile Gln Arg Leu Leu Met Lys Asp Pro Lys Lys Arg Leu Gly Cys 
    290                 295                 300                 


Gly Pro Arg Asp Ala Asp Glu Ile Lys Glu His Leu Phe Phe Gln Lys 
305                 310                 315                 320 


Ile Asn Trp Asp Asp Leu Ala Ala Lys Lys Val Pro Ala Pro Phe Lys 
                325                 330                 335     


Pro Val Ile Arg Asp Glu Leu Asp Val Ser Asn Phe Ala Glu Glu Phe 
            340                 345                 350         


Thr Glu Met Asp Pro Thr Tyr Ser Pro Ala Ala Leu Pro Gln Ser Ser 
        355                 360                 365             


Glu Lys Leu Phe Gln Gly Tyr Ser Phe Val Ala Pro Ser Ile Leu Phe 
    370                 375                 380                 


Lys Arg Asn Ala Ala Val Ile Asp Pro Leu Gln Phe His Met Gly Val 
385                 390                 395                 400 


Glu Arg Pro Gly Val Thr Asn Val Ala Arg Ser Ala Met Met Lys Asp 
                405                 410                 415     


Ser Pro Phe Tyr Gln His Tyr Asp Leu Asp Leu Lys Asp Lys Pro Leu 
            420                 425                 430         


Gly Glu Gly Ser Phe Ser Ile Cys Arg Lys Cys Val His Lys Lys Ser 
        435                 440                 445             


Asn Gln Ala Phe Ala Val Lys Ile Ile Ser Lys Arg Met Glu Ala Asn 
    450                 455                 460                 


Thr Gln Lys Glu Ile Thr Ala Leu Lys Leu Cys Glu Gly His Pro Asn 
465                 470                 475                 480 


Ile Val Lys Leu His Glu Val Phe His Asp Gln Leu His Thr Phe Leu 
                485                 490                 495     


Val Met Glu Leu Leu Asn Gly Gly Glu Leu Phe Glu Arg Ile Lys Lys 
            500                 505                 510         


Lys Lys His Phe Ser Glu Thr Glu Ala Ser Tyr Ile Met Arg Lys Leu 
        515                 520                 525             


Val Ser Ala Val Ser His Met His Asp Val Gly Val Val His Arg Asp 
    530                 535                 540                 


Leu Lys Pro Glu Asn Leu Leu Phe Thr Asp Glu Asn Asp Asn Leu Glu 
545                 550                 555                 560 


Ile Lys Ile Ile Asp Phe Gly Phe Ala Arg Leu Lys Pro Pro Asp Asn 
                565                 570                 575     


Gln Pro Leu Lys Thr Pro Cys Phe Thr Leu His Tyr Ala Ala Pro Glu 
            580                 585                 590         


Leu Leu Asn Gln Asn Gly Tyr Asp Glu Ser Cys Asp Leu Trp Ser Leu 
        595                 600                 605             


Gly Val Ile Leu Tyr Thr Met Leu Ser Gly Gln Val Pro Phe Gln Ser 
    610                 615                 620                 


His Asp Arg Ser Leu Thr Cys Thr Ser Ala Val Glu Ile Met Lys Lys 
625                 630                 635                 640 


Ile Lys Lys Gly Asp Phe Ser Phe Glu Gly Glu Ala Trp Lys Asn Val 
                645                 650                 655     


Ser Gln Glu Ala Lys Asp Leu Ile Gln Gly Leu Leu Thr Val Asp Pro 
            660                 665                 670         


Asn Lys Arg Leu Lys Met Ser Gly Leu Arg Tyr Asn Glu Trp Leu Gln 
        675                 680                 685             


Asp Gly Ser Gln Leu Ser Ser Asn Pro Leu Met Thr Pro Asp Ile Leu 
    690                 695                 700                 


Gly Ser Ser Gly Ala Ala Val His Thr Cys Val Lys Ala Thr Phe His 
705                 710                 715                 720 


Ala Phe Asn Lys Tyr Lys Arg Glu Gly Phe Cys Leu Gln Asn Val Asp 
                725                 730                 735     


Lys Ala Pro Leu Ala Lys Arg Arg Lys Met Lys Lys Thr Ser Thr Ser 
            740                 745                 750         


Thr Glu Thr Arg Ser Ser Ser Ser Glu Ser Ser His Ser Ser Ser Ser 
        755                 760                 765             


His Ser His Gly Lys Thr Thr Pro Thr Lys Thr Leu Gln Pro Ser Asn 
    770                 775                 780                 


Pro Ala Asp Ser Asn Asn Pro Glu Thr Leu Phe Gln Phe Ser Asp Ser 
785                 790                 795                 800 


Val Ala 
        


<210>  2
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Glu Ile Arg Leu Arg His Val Val Ser Cys Ser Ser Gln Asp 
1               5                   10                  15      


Ser Thr His Cys Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg Lys 
            20                  25                  30          


Trp Arg Ala Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu Gln 
        35                  40                  45              


Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp Gly 
    50                  55                  60                  


Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala Gly 
65                  70                  75                  80  


Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met Ser Pro 
                85                  90                  95      


Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Met Phe Gly 
            100                 105                 110         


Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp Arg Val 
        115                 120                 125             


Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Phe Gly Leu 
    130                 135                 140                 


Ser Phe Val Arg Phe His Ser Pro Pro Asp Lys Asp Glu Ala Glu Ala 
145                 150                 155                 160 


Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg Val Lys 
                165                 170                 175     


Glu Glu Asp Glu Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu Phe Phe 
            180                 185                 190         


Ser Arg Ile Asn Lys Thr Ser Pro Val Thr Ala Ser Asp Pro Ala Gly 
        195                 200                 205             


Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala Ser Ser 
    210                 215                 220                 


Ala Ser Pro Val Ser Arg Ala Ile Gly Ser Thr Ser Lys Pro Gln Glu 
225                 230                 235                 240 


Ser Pro Lys Gly Lys Arg Lys Leu Asp Leu Asn Gln Glu Glu Lys Lys 
                245                 250                 255     


Thr Pro Ser Lys Pro Pro Ala Gln Leu Ser Pro Ser Val Pro Lys Arg 
            260                 265                 270         


Pro Lys Leu Pro Ala Pro Thr Arg Thr Pro Ala Thr Ala Pro Val Pro 
        275                 280                 285             


Ala Arg Ala Gln Gly Ala Val Thr Gly Lys Pro Arg Gly Glu Gly Thr 
    290                 295                 300                 


Glu Pro Arg Arg Pro Arg Ala Gly Pro Glu Glu Leu Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg Ser 
                325                 330                 335     


Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro Asp 
            340                 345                 350         


Trp Thr Arg Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr Pro 
        355                 360                 365             


Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys Glu 
    370                 375                 380                 


Trp Val Leu Asp Cys His Arg Met Arg Arg Arg Leu Pro Ser Arg Arg 
385                 390                 395                 400 


Tyr Leu Met Ala Gly Pro Gly Ser Ser Ser Glu Glu Asp Glu Ala Ser 
                405                 410                 415     


His Ser Gly Gly Ser Gly Asp Glu Ala Pro Lys Leu Pro Gln Lys Gln 
            420                 425                 430         


Pro Gln Thr Lys Thr Lys Pro Thr Gln Ala Ala Gly Pro Ser Ser Pro 
        435                 440                 445             


Gln Lys Pro Pro Thr Pro Glu Glu Thr Lys Ala Ala Ser Pro Val Leu 
    450                 455                 460                 


Gln Glu Asp Ile Asp Ile Glu Gly Val Gln Ser Glu Gly Gln Asp Asn 
465                 470                 475                 480 


Gly Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val Ala 
                485                 490                 495     


Glu Gln Lys Glu His Arg Leu Pro Pro Gly Gln Glu Glu Asn Gly Glu 
            500                 505                 510         


Asp Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Glu His 
        515                 520                 525             


Gln Glu Pro Pro Asp Leu Pro Val Pro Glu Leu Pro Asp Phe Phe Gln 
    530                 535                 540                 


Gly Lys His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg Arg 
545                 550                 555                 560 


Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp Asn 
                565                 570                 575     


Met Ser Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp Pro 
            580                 585                 590         


Ser Phe Glu Glu Ala Leu Met Asp Asn Pro Ser Leu Ala Phe Val Arg 
        595                 600                 605             


Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro His 
    610                 615                 620                 


Gln Leu Tyr Gly Val Val Pro Gln Ala 
625                 630             


<210>  3
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Leu Leu Ala Arg Ala Leu Arg Leu Cys Glu Phe Gly Arg Gln 
1               5                   10                  15      


Ala Ser Ser Arg Arg Leu Val Ala Gly Gln Gly Cys Val Gly Pro Arg 
            20                  25                  30          


Arg Gly Cys Cys Ala Pro Val Gln Val Val Gly Pro Arg Ala Asp Leu 
        35                  40                  45              


Pro Pro Cys Gly Ala Cys Ile Thr Gly Arg Ile Met Arg Pro Asp Asp 
    50                  55                  60                  


Ala Asn Val Ala Gly Asn Val His Gly Gly Thr Ile Leu Lys Met Ile 
65                  70                  75                  80  


Glu Glu Ala Gly Ala Ile Ile Ser Thr Arg His Cys Asn Ser Gln Asn 
                85                  90                  95      


Gly Glu Arg Cys Val Ala Ala Leu Ala Arg Val Glu Arg Thr Asp Phe 
            100                 105                 110         


Leu Ser Pro Met Cys Ile Gly Glu Val Ala His Val Ser Ala Glu Ile 
        115                 120                 125             


Thr Tyr Thr Ser Lys His Ser Val Glu Val Gln Val Asn Val Met Ser 
    130                 135                 140                 


Glu Asn Ile Leu Thr Gly Ala Lys Lys Leu Thr Asn Lys Ala Thr Leu 
145                 150                 155                 160 


Trp Tyr Val Pro Leu Ser Leu Lys Asn Val Asp Lys Val Leu Glu Val 
                165                 170                 175     


Pro Pro Val Val Tyr Ser Arg Gln Glu Gln Glu Glu Glu Gly Arg Lys 
            180                 185                 190         


Arg Tyr Glu Ala Gln Lys Leu Glu Arg Met Glu Thr Lys Trp Arg Asn 
        195                 200                 205             


Gly Asp Ile Val Gln Pro Val Leu Asn Pro Glu Pro Asn Thr Val Ser 
    210                 215                 220                 


Tyr Ser Gln Ser Ser Leu Ile His Leu Val Gly Pro Ser Asp Cys Thr 
225                 230                 235                 240 


Leu His Gly Phe Val His Gly Gly Val Thr Met Lys Leu Met Asp Glu 
                245                 250                 255     


Val Ala Gly Ile Val Ala Ala Arg His Cys Lys Thr Asn Ile Val Thr 
            260                 265                 270         


Ala Ser Val Asp Ala Ile Asn Phe His Asp Lys Ile Arg Lys Gly Cys 
        275                 280                 285             


Val Ile Thr Ile Ser Gly Arg Met Thr Phe Thr Ser Asn Lys Ser Met 
    290                 295                 300                 


Glu Ile Glu Val Leu Val Asp Ala Asp Pro Val Val Asp Ser Ser Gln 
305                 310                 315                 320 


Lys Arg Tyr Arg Ala Ala Ser Ala Phe Phe Thr Tyr Val Ser Leu Ser 
                325                 330                 335     


Gln Glu Gly Arg Ser Leu Pro Val Pro Gln Leu Val Pro Glu Thr Glu 
            340                 345                 350         


Asp Glu Lys Lys Arg Phe Glu Glu Gly Lys Gly Arg Tyr Leu Gln Met 
        355                 360                 365             


Lys Ala Lys Arg Gln Gly His Ala Glu Pro Gln Pro 
    370                 375                 380 


<210>  4
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Thr Lys Ser Ile Leu Glu Glu Leu Leu Leu Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Met Ser Pro Asn Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Thr Lys Thr Asn Leu Ser Tyr Tyr Glu Tyr Asp Lys Met Lys Arg 
        35                  40                  45              


Gly Ser Arg Lys Gly Ser Ile Glu Ile Lys Lys Ile Arg Cys Val Glu 
    50                  55                  60                  


Lys Val Asn Leu Glu Glu Gln Thr Pro Val Glu Arg Gln Tyr Pro Phe 
65                  70                  75                  80  


Gln Ile Val Tyr Lys Asp Gly Leu Leu Tyr Val Tyr Ala Ser Asn Glu 
                85                  90                  95      


Glu Ser Arg Ser Gln Trp Leu Lys Ala Leu Gln Lys Glu Ile Arg Gly 
            100                 105                 110         


Asn Pro His Leu Leu Val Lys Tyr His Ser Gly Phe Phe Val Asp Gly 
        115                 120                 125             


Lys Phe Leu Cys Cys Gln Gln Ser Cys Lys Ala Ala Pro Gly Cys Thr 
    130                 135                 140                 


Leu Trp Glu Ala Tyr Ala Asn Leu His Thr Ala Val Asn Glu Glu Lys 
145                 150                 155                 160 


His Arg Val Pro Thr Phe Pro Asp Arg Val Leu Lys Ile Pro Arg Ala 
                165                 170                 175     


Val Pro Val Leu Lys Met Asp Ala Pro Ser Ser Ser Thr Thr Leu Ala 
            180                 185                 190         


Gln Tyr Asp Asn Glu Ser Lys Lys Asn Tyr Gly Ser Gln Pro Pro Ser 
        195                 200                 205             


Ser Ser Thr Ser Leu Ala Gln Tyr Asp Ser Asn Ser Lys Lys Ile Tyr 
    210                 215                 220                 


Gly Ser Gln Pro Asn Phe Asn Met Gln Tyr Ile Pro Arg Glu Asp Phe 
225                 230                 235                 240 


Pro Asp Trp Trp Gln Val Arg Lys Leu Lys Ser Ser Ser Ser Ser Glu 
                245                 250                 255     


Asp Val Ala Ser Ser Asn Gln Lys Glu Arg Asn Val Asn His Thr Thr 
            260                 265                 270         


Ser Lys Ile Ser Trp Glu Phe Pro Glu Ser Ser Ser Ser Glu Glu Glu 
        275                 280                 285             


Glu Asn Leu Asp Asp Tyr Asp Trp Phe Ala Gly Asn Ile Ser Arg Ser 
    290                 295                 300                 


Gln Ser Glu Gln Leu Leu Arg Gln Lys Gly Lys Glu Gly Ala Phe Met 
305                 310                 315                 320 


Val Arg Asn Ser Ser Gln Val Gly Met Tyr Thr Val Ser Leu Phe Ser 
                325                 330                 335     


Lys Ala Val Asn Asp Lys Lys Gly Thr Val Lys His Tyr His Val His 
            340                 345                 350         


Thr Asn Ala Glu Asn Lys Leu Tyr Leu Ala Glu Asn Tyr Cys Phe Asp 
        355                 360                 365             


Ser Ile Pro Lys Leu Ile His Tyr His Gln His Asn Ser Ala Gly Met 
    370                 375                 380                 


Ile Thr Arg Leu Arg His Pro Val Ser Thr Lys Ala Asn Lys Val Pro 
385                 390                 395                 400 


Asp Ser Val Ser Leu Gly Asn Gly Ile Trp Glu Leu Lys Arg Glu Glu 
                405                 410                 415     


Ile Thr Leu Leu Lys Glu Leu Gly Ser Gly Gln Phe Gly Val Val Gln 
            420                 425                 430         


Leu Gly Lys Trp Lys Gly Gln Tyr Asp Val Ala Val Lys Met Ile Lys 
        435                 440                 445             


Glu Gly Ser Met Ser Glu Asp Glu Phe Phe Gln Glu Ala Gln Thr Met 
    450                 455                 460                 


Met Lys Leu Ser His Pro Lys Leu Val Lys Phe Tyr Gly Val Cys Ser 
465                 470                 475                 480 


Lys Glu Tyr Pro Ile Tyr Ile Val Thr Glu Tyr Ile Ser Asn Gly Cys 
                485                 490                 495     


Leu Leu Asn Tyr Leu Arg Ser His Gly Lys Gly Leu Glu Pro Ser Gln 
            500                 505                 510         


Leu Leu Glu Met Cys Tyr Asp Val Cys Glu Gly Met Ala Phe Leu Glu 
        515                 520                 525             


Ser His Gln Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    530                 535                 540                 


Asp Arg Asp Leu Cys Val Lys Val Ser Asp Phe Gly Met Thr Arg Tyr 
545                 550                 555                 560 


Val Leu Asp Asp Gln Tyr Val Ser Ser Val Gly Thr Lys Phe Pro Val 
                565                 570                 575     


Lys Trp Ser Ala Pro Glu Val Phe His Tyr Phe Lys Tyr Ser Ser Lys 
            580                 585                 590         


Ser Asp Val Trp Ala Phe Gly Ile Leu Met Trp Glu Val Phe Ser Leu 
        595                 600                 605             


Gly Lys Gln Pro Tyr Asp Leu Tyr Asp Asn Ser Gln Val Val Leu Lys 
    610                 615                 620                 


Val Ser Gln Gly His Arg Leu Tyr Arg Pro His Leu Ala Ser Asp Thr 
625                 630                 635                 640 


Ile Tyr Gln Ile Met Tyr Ser Cys Trp His Glu Leu Pro Glu Lys Arg 
                645                 650                 655     


Pro Thr Phe Gln Gln Leu Leu Ser Ser Ile Glu Pro Leu Arg Glu Lys 
            660                 665                 670         


Asp Lys His 
        675 


<210>  5
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  6
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu 
    130                 135                 140                 


Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp 
                165                 170                 175     


Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser 
            180                 185                 190         


Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu 
        195                 200                 205             


Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu 
    210                 215                 220                 


Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala 
225                 230                 235                 240 


Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp 
                245                 250                 255     


Leu Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser 
            260                 265                 270         


Glu Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 285 


<210>  7
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Arg Ile Glu Ser Leu Thr Arg Ala Arg Ile Asp Arg Ser Arg 
1               5                   10                  15      


Glu Leu Ala Ser Lys Thr Arg Glu Lys Glu Lys Met Lys Glu Ala Lys 
            20                  25                  30          


Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr Thr Ile Ser Val Ser 
        35                  40                  45              


Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser Ile Thr Ala Lys Glu 
    50                  55                  60                  


Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile His Asn Arg Cys Lys 
65                  70                  75                  80  


Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln Lys Gln Gln Lys Ala 
                85                  90                  95      


Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser Val Ser Leu Arg Ser 
            100                 105                 110         


Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp 
        115                 120                 125             


Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu 
    130                 135                 140                 


Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile Ala Gly His Phe Asn 
145                 150                 155                 160 


Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Thr Asp 
                165                 170                 175     


Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val Glu Ser Leu Ile Asp 
            180                 185                 190         


Glu Ala Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp 
        195                 200                 205             


Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser 
    210                 215                 220                 


Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile 
225                 230                 235                 240 


Tyr Glu Leu Ile Gln Thr Glu Leu His His Val Arg Thr Leu Lys Ile 
                245                 250                 255     


Met Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu Leu His Leu Glu 
            260                 265                 270         


Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp 
        275                 280                 285             


Ile His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala 
    290                 295                 300                 


Leu Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His Arg Leu Gly Asp 
305                 310                 315                 320 


Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys 
                325                 330                 335     


Thr Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr 
            340                 345                 350         


Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys 
        355                 360                 365             


Val Thr Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile 
    370                 375                 380                 


Leu Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu Leu Ile Ser Arg 
385                 390                 395                 400 


Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Thr 
                405                 410                 415     


Thr Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly 
            420                 425                 430         


Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg 
        435                 440                 445             


Met Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys Gly Pro Phe Gly 
    450                 455                 460                 


Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu 
465                 470                 475                 480 


Trp Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met 
                485                 490                 495     


Thr Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe 
            500                 505                 510         


Pro Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val 
        515                 520                 525             


Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala 
    530                 535                 540                 


Pro Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg Asp Asp Arg Ser 
545                 550                 555                 560 


Thr Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr Cys Pro Ser Arg 
                565                 570                 575     


Glu Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala Tyr Leu Arg Arg 
            580                 585                 590         


Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu 
        595                 600                 605             


Arg Glu Lys Val Gly Leu Phe Ala Glu Met Thr His Phe Gln Ala Glu 
    610                 615                 620                 


Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu Pro Arg Gly Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln 
                645                 650                 655     


Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro 
            660                 665                 670         


Gly Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala Leu Pro Leu Glu 
        675                 680                 685             


Pro Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr Ala Asn Gly Glu 
    690                 695                 700                 


Ala Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp 
705                 710                 715                 720 


Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu 
                725                 730                 735     


Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu 
            740                 745                 750         


Gln Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu Ala Arg Phe Pro 
        755                 760                 765             


Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp 
    770                 775                 780                 


Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln 
785                 790                 795                 800 


Ala Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu 
                805                 810                 815     


Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Thr Glu Ala 
            820                 825                 830         


Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu 
        835                 840                 845             


Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly 
    850                 855                 860                 


Gln Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val 
865                 870                 875                 880 


Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser 
                885                 890                 895     


Phe Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg Leu Asp Leu Pro 
            900                 905                 910         


Val Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln 
        915                 920                 925             


Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp 
    930                 935                 940                 


Thr Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser 
945                 950                 955                 960 


Pro Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu Glu Thr Glu Ser 
                965                 970                 975     


Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 
            980                 985     


<210>  8
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Tyr Val Asp Arg Gln Asn Arg Ile Cys Gly Phe Leu Asp Ile 
1               5                   10                  15      


Glu Glu Asn Glu Asn Ser Gly Lys Phe Leu Arg Arg Tyr Phe Ile Leu 
            20                  25                  30          


Asp Thr Arg Glu Asp Ser Phe Val Trp Tyr Met Asp Asn Pro Gln Asn 
        35                  40                  45              


Leu Pro Ser Gly Ser Ser Arg Val Gly Ala Ile Lys Leu Thr Tyr Ile 
    50                  55                  60                  


Ser Lys Val Ser Asp Ala Thr Lys Leu Arg Pro Lys Ala Glu Phe Cys 
65                  70                  75                  80  


Phe Val Met Asn Ala Gly Met Arg Lys Tyr Phe Leu Gln Ala Asn Asp 
                85                  90                  95      


Gln Gln Asp Leu Val Glu Trp Val Asn Val Leu Asn Lys Ala Ile Lys 
            100                 105                 110         


Ile Thr Val Pro Lys Gln Ser Asp Ser Gln Pro Asn Ser Asp Asn Leu 
        115                 120                 125             


Ser Arg His Gly Glu Cys Gly Lys Lys Gln Val Ser Tyr Arg Thr Asp 
    130                 135                 140                 


Ile Val Gly Gly Val Pro Ile Ile Thr Pro Thr Gln Lys Glu Glu Val 
145                 150                 155                 160 


Asn Glu Cys Gly Glu Ser Ile Asp Arg Asn Asn Leu Lys Arg Ser Gln 
                165                 170                 175     


Ser His Leu Pro Tyr Phe Thr Pro Lys Pro Pro Gln Asp Ser Ala Val 
            180                 185                 190         


Ile Lys Ala Gly Tyr Cys Val Lys Gln Gly Ala Val Met Lys Asn Trp 
        195                 200                 205             


Lys Arg Arg Tyr Phe Gln Leu Asp Glu Asn Thr Ile Gly Tyr Phe Lys 
    210                 215                 220                 


Ser Glu Leu Glu Lys Glu Pro Leu Arg Val Ile Pro Leu Lys Glu Val 
225                 230                 235                 240 


His Lys Val Gln Glu Cys Lys Gln Ser Asp Ile Met Met Arg Asp Asn 
                245                 250                 255     


Leu Phe Glu Ile Val Thr Thr Ser Arg Thr Phe Tyr Val Gln Ala Asp 
            260                 265                 270         


Ser Pro Glu Glu Met His Ser Trp Ile Lys Ala Val Ser Gly Ala Ile 
        275                 280                 285             


Val Ala Gln Arg Gly Pro Gly Arg Ser Ala Ser Ser Glu His Pro Pro 
    290                 295                 300                 


Gly Pro Ser Glu Ser Lys His Ala Phe Arg Pro Thr Asn Ala Ala Thr 
305                 310                 315                 320 


Ala Thr Ser His Ser Thr Ala Ser Arg Ser Asn Ser Leu Val Ser Thr 
                325                 330                 335     


Phe Thr Met Glu Lys Arg Gly Phe Tyr Glu Ser Leu Ala Lys Val Lys 
            340                 345                 350         


Pro Gly Asn Phe Lys Val Gln Thr Val Ser Pro Arg Glu Pro Ala Ser 
        355                 360                 365             


Lys Val Thr Glu Gln Ala Leu Leu Arg Pro Gln Ser Lys Asn Gly Pro 
    370                 375                 380                 


Gln Glu Lys Asp Cys Asp Leu Val Asp Leu Asp Asp Ala Ser Leu Pro 
385                 390                 395                 400 


Val Ser Asp Val 
                


<210>  9
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Ala Ala Gly Ser Cys Ala Arg Val Ala Ala Trp Gly Gly 
1               5                   10                  15      


Lys Leu Arg Arg Gly Leu Ala Val Ser Arg Gln Ala Val Arg Ser Pro 
            20                  25                  30          


Gly Pro Leu Ala Ala Ala Val Ala Gly Ala Ala Leu Ala Gly Ala Gly 
        35                  40                  45              


Ala Ala Trp His His Ser Arg Val Ser Val Ala Ala Arg Asp Gly Ser 
    50                  55                  60                  


Phe Thr Val Ser Ala Gln Lys Asn Val Glu His Gly Ile Ile Tyr Ile 
65                  70                  75                  80  


Gly Lys Pro Ser Leu Arg Lys Gln Arg Phe Met Gln Phe Ser Ser Leu 
                85                  90                  95      


Glu His Glu Gly Glu Tyr Tyr Met Thr Pro Arg Asp Phe Leu Phe Ser 
            100                 105                 110         


Val Met Phe Glu Gln Met Glu Arg Lys Thr Ser Val Lys Lys Leu Thr 
        115                 120                 125             


Lys Lys Asp Ile Glu Asp Thr Leu Ser Gly Ile Gln Thr Ala Gly Cys 
    130                 135                 140                 


Gly Ser Thr Phe Phe Arg Asp Leu Gly Asp Lys Gly Leu Ile Ser Tyr 
145                 150                 155                 160 


Thr Glu Tyr Leu Phe Leu Leu Thr Ile Leu Thr Lys Pro His Ser Gly 
                165                 170                 175     


Phe His Val Ala Phe Lys Met Leu Asp Thr Asp Gly Asn Glu Met Ile 
            180                 185                 190         


Glu Lys Arg Glu Phe Phe Lys Leu Gln Lys Ile Ile Ser Lys Gln Asp 
        195                 200                 205             


Asp Leu Met Thr Val Lys Thr Asn Glu Thr Gly Tyr Gln Glu Ala Ile 
    210                 215                 220                 


Val Lys Glu Pro Glu Ile Asn Thr Thr Leu Gln Met Arg Phe Phe Gly 
225                 230                 235                 240 


Lys Arg Gly Gln Arg Lys Leu His Tyr Lys Glu Phe Arg Arg Phe Met 
                245                 250                 255     


Glu Asn Leu Gln Thr Glu Ile Gln Glu Met Glu Phe Leu Gln Phe Ser 
            260                 265                 270         


Lys Gly Leu Ser Phe Met Arg Lys Glu Asp Phe Ala Glu Trp Leu Leu 
        275                 280                 285             


Phe Phe Thr Asn Thr Glu Asn Lys Asp Ile Tyr Trp Lys Asn Val Arg 
    290                 295                 300                 


Glu Lys Leu Ser Ala Gly Glu Ser Ile Ser Leu Asp Glu Phe Lys Ser 
305                 310                 315                 320 


Phe Cys His Phe Thr Thr His Leu Glu Asp Phe Ala Ile Ala Met Gln 
                325                 330                 335     


Met Phe Ser Leu Ala His Arg Pro Val Arg Leu Ala Glu Phe Lys Arg 
            340                 345                 350         


Ala Val Lys Val Ala Thr Gly Gln Glu Leu Ser Asn Asn Ile Leu Asp 
        355                 360                 365             


Thr Val Phe Lys Ile Phe Asp Leu Asp Gly Asp Glu Cys Leu Ser His 
    370                 375                 380                 


Glu Glu Phe Leu Gly Val Leu Lys Asn Arg Met His Arg Gly Leu Trp 
385                 390                 395                 400 


Val Pro Gln His Gln Ser Ile Gln Glu Tyr Trp Lys Cys Val Lys Lys 
                405                 410                 415     


Glu Ser Ile Lys Gly Val Lys Glu Val Trp Lys Gln Ala Gly Lys Gly 
            420                 425                 430         


Leu Phe 
        


<210>  10
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Leu Val His Val Gly Tyr Leu Val Leu Pro Val Phe Gly Ser 
1               5                   10                  15      


Val Arg Asn Arg Gly Ala Pro Phe Gln Arg Ser Gln His Pro His Ala 
            20                  25                  30          


Thr Ser Cys Arg His Phe His Leu Gly Pro Pro Gln Pro Gln Gln Leu 
        35                  40                  45              


Ala Pro Asp Phe Pro Leu Ala His Pro Val Gln Ser Gln Pro Gly Leu 
    50                  55                  60                  


Ser Ala His Met Ala Pro Ala His Gln His Ser Gly Ala Leu His Gln 
65                  70                  75                  80  


Ser Leu Thr Pro Leu Pro Thr Leu Gln Phe Gln Asp Val Thr Gly Pro 
                85                  90                  95      


Ser Phe Leu Pro Gln Ala Leu His Gln Gln Tyr Leu Leu Gln Gln Gln 
            100                 105                 110         


Leu Leu Glu Ala Gln His Arg Arg Leu Val Ser His Pro Arg Arg Ser 
        115                 120                 125             


Gln Glu Arg Val Ser Val His Pro His Arg Leu His Pro Ser Phe Asp 
    130                 135                 140                 


Phe Gly Gln Leu Gln Thr Pro Gln Pro Arg Tyr Leu Ala Glu Gly Thr 
145                 150                 155                 160 


Asp Trp Asp Leu Ser Val Asp Ala Gly Leu Ser Pro Ala Gln Phe Gln 
                165                 170                 175     


Val Arg Pro Ile Pro Gln His Tyr Gln His Tyr Leu Ala Thr Pro Arg 
            180                 185                 190         


Met His His Phe Pro Arg Asn Ser Ser Ser Thr Gln Met Val Val His 
        195                 200                 205             


Glu Ile Arg Asn Tyr Pro Tyr Pro Gln Leu His Phe Leu Ala Leu Gln 
    210                 215                 220                 


Gly Leu Asn Pro Ser Arg His Thr Ser Ala Val Arg Glu Ser Tyr Glu 
225                 230                 235                 240 


Glu Leu Leu Gln Leu Glu Asp Arg Leu Gly Asn Val Thr Arg Gly Ala 
                245                 250                 255     


Val Gln Asn Thr Ile Glu Arg Phe Thr Phe Pro His Lys Tyr Lys Lys 
            260                 265                 270         


Arg Arg Pro Gln Asp Gly Lys Gly Lys Lys Asp Glu Gly Glu Glu Ser 
        275                 280                 285             


Asp Thr Asp Glu Lys Cys Thr Ile Cys Leu Ser Met Leu Glu Asp Gly 
    290                 295                 300                 


Glu Asp Val Arg Arg Leu Pro Cys Met His Leu Phe His Gln Leu Cys 
305                 310                 315                 320 


Val Asp Gln Trp Leu Ala Met Ser Lys Lys Cys Pro Ile Cys Arg Val 
                325                 330                 335     


Asp Ile Glu Thr Gln Leu Gly Ala Asp Ser 
            340                 345     


<210>  11
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ser Thr Leu Pro Ala Leu Leu Cys Val Gly Leu Cys Leu Ser 
1               5                   10                  15      


Gln Arg Ile Ser Ala Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp 
            20                  25                  30          


Ala Glu Pro His Phe Met Val Pro Lys Glu Lys Gln Val Thr Ile Cys 
        35                  40                  45              


Cys Gln Gly Asn Tyr Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly 
    50                  55                  60                  


Ser Leu Phe Ala Val Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys 
65                  70                  75                  80  


Val Lys Phe Tyr Ile Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr 
                85                  90                  95      


Ser Cys Ile Tyr Arg Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu 
            100                 105                 110         


Leu Asp Leu Val Val Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val 
        115                 120                 125             


His Pro Gly Pro Glu Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys 
    130                 135                 140                 


Arg Leu Asp Thr Ala Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg 
145                 150                 155                 160 


Ser Ser His Val Gln Arg Gly Tyr Gly Lys Val Gln Ala Glu Phe Pro 
                165                 170                 175     


Leu Gly Pro Val Thr Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly 
            180                 185                 190         


Ser Tyr Asn Asn His Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu 
        195                 200                 205             


Leu Val Thr Gly Asp Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro 
    210                 215                 220                 


Thr Phe Pro Ala Asp Thr Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr 
225                 230                 235                 240 


Gly Leu Gln Lys Asp His Ala Leu Trp Asp His Thr Ala Gln Asn Leu 
                245                 250                 255     


Leu Arg Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe 
            260                 265                 270         


Leu Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser 
        275                 280                 285             


Arg Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
    290                 295                 300                 


<210>  12
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Val Pro Ser Leu Lys Leu Gln Asp Leu Ile Glu Glu Ile Arg 
1               5                   10                  15      


Gly Ala Lys Thr Gln Ala Gln Glu Arg Glu Val Ile Gln Lys Glu Cys 
            20                  25                  30          


Ala His Ile Arg Ala Ser Phe Arg Asp Gly Asp Pro Val His Arg His 
        35                  40                  45              


Arg Gln Leu Ala Lys Leu Leu Tyr Val His Met Leu Gly Tyr Pro Ala 
    50                  55                  60                  


His Phe Gly Gln Met Glu Cys Leu Lys Leu Ile Ala Ser Ser Arg Phe 
65                  70                  75                  80  


Thr Asp Lys Arg Val Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu 
                85                  90                  95      


Arg His Asp Ala His Leu Leu Ile Thr Asn Ser Ile Lys Asn Asp Leu 
            100                 105                 110         


Ser Gln Gly Ile Gln Pro Val Gln Gly Leu Ala Leu Cys Thr Leu Ser 
        115                 120                 125             


Thr Met Gly Ser Ala Glu Met Cys Arg Asp Leu Ala Pro Glu Val Glu 
    130                 135                 140                 


Lys Leu Leu Leu Gln Pro Ser Pro Tyr Val Arg Lys Lys Ala Ile Leu 
145                 150                 155                 160 


Thr Ala Val His Met Ile Arg Lys Val Pro Glu Leu Ser Ser Val Phe 
                165                 170                 175     


Leu Pro Pro Cys Ala Gln Leu Leu His Glu Arg His His Gly Ile Leu 
            180                 185                 190         


Leu Gly Thr Ile Thr Leu Ile Thr Glu Leu Cys Glu Arg Ser Pro Ala 
        195                 200                 205             


Ala Leu Arg His Phe Arg Lys Val Val Pro Gln Leu Val His Ile Leu 
    210                 215                 220                 


Arg Thr Leu Val Thr Met Gly Tyr Ser Thr Glu His Ser Ile Ser Gly 
225                 230                 235                 240 


Val Ser Asp Pro Phe Leu Gln Val Gln Ile Leu Arg Leu Leu Arg Ile 
                245                 250                 255     


Leu Gly Arg Asn His Glu Glu Ser Ser Glu Thr Met Asn Asp Leu Leu 
            260                 265                 270         


Ala Gln Val Ala Thr Asn Thr Asp Thr Ser Arg Asn Ala Gly Asn Ala 
        275                 280                 285             


Val Leu Phe Glu Thr Val Leu Thr Ile Met Asp Ile Arg Ser Ala Ala 
    290                 295                 300                 


Gly Leu Arg Val Leu Ala Val Asn Ile Leu Gly Arg Phe Leu Leu Asn 
305                 310                 315                 320 


Ser Asp Arg Asn Ile Arg Tyr Val Ala Leu Thr Ser Leu Leu Arg Leu 
                325                 330                 335     


Val Gln Ser Asp His Ser Ala Val Gln Arg His Arg Pro Thr Val Val 
            340                 345                 350         


Glu Cys Leu Arg Glu Thr Asp Ala Ser Leu Ser Arg Arg Ala Leu Glu 
        355                 360                 365             


Leu Ser Leu Ala Leu Val Asn Ser Ser Asn Val Arg Ala Met Met Gln 
    370                 375                 380                 


Glu Leu Gln Ala Phe Leu Glu Ser Cys Pro Pro Asp Leu Arg Ala Asp 
385                 390                 395                 400 


Cys Ala Ser Gly Ile Leu Leu Ala Ala Glu Arg Phe Ala Pro Thr Lys 
                405                 410                 415     


Arg Trp His Ile Asp Thr Ile Leu His Val Leu Thr Thr Ala Gly Thr 
            420                 425                 430         


His Val Arg Asp Asp Ala Val Ala Asn Leu Thr Gln Leu Ile Gly Gly 
        435                 440                 445             


Ala Gln Glu Leu His Ala Tyr Ser Val Arg Arg Leu Tyr Asn Ala Leu 
    450                 455                 460                 


Ala Glu Asp Ile Ser Gln Gln Pro Leu Val Gln Val Ala Ala Trp Cys 
465                 470                 475                 480 


Ile Gly Glu Tyr Gly Asp Leu Leu Leu Ala Gly Asn Cys Glu Glu Ile 
                485                 490                 495     


Glu Pro Leu Gln Val Asp Glu Glu Glu Val Leu Ala Leu Leu Glu Lys 
            500                 505                 510         


Val Leu Gln Ser His Met Ser Leu Pro Ala Thr Arg Gly Tyr Ala Leu 
        515                 520                 525             


Thr Ala Leu Met Lys Leu Ser Thr Arg Leu Cys Gly Asp Asn Asn Arg 
    530                 535                 540                 


Ile Arg Gln Val Val Ser Ile Tyr Gly Ser Cys Leu Asp Val Glu Leu 
545                 550                 555                 560 


Gln Gln Arg Ala Val Glu Tyr Asp Thr Leu Phe Arg Lys Tyr Asp His 
                565                 570                 575     


Met Arg Ala Ala Ile Leu Glu Lys Met Pro Leu Val Glu Arg Asp Gly 
            580                 585                 590         


Pro Gln Ala Asp Glu Glu Ala Lys Glu Ser Lys Glu Ala Ala Gln Leu 
        595                 600                 605             


Ser Glu Ala Ala Pro Val Pro Thr Glu Pro Gln Ala Ser Gln Leu Leu 
    610                 615                 620                 


Asp Leu Leu Asp Leu Leu Asp Gly Ala Ser Gly Asp Val Gln His Pro 
625                 630                 635                 640 


Pro His Leu Asp Pro Ser Pro Gly Gly Ala Leu Val His Leu Leu Asp 
                645                 650                 655     


Leu Pro Cys Val Pro Pro Pro Pro Ala Pro Ile Pro Asp Leu Lys Val 
            660                 665                 670         


Phe Glu Arg Glu Gly Val Gln Leu Asn Leu Ser Phe Ile Arg Pro Pro 
        675                 680                 685             


Glu Asn Pro Ala Leu Leu Leu Ile Thr Ile Thr Ala Thr Asn Phe Ser 
    690                 695                 700                 


Glu Gly Asp Val Thr His Phe Ile Cys Gln Ala Ala Val Pro Lys Ser 
705                 710                 715                 720 


Leu Gln Leu Gln Leu Gln Ala Pro Ser Gly Asn Thr Val Pro Ala Arg 
                725                 730                 735     


Gly Gly Leu Pro Ile Thr Gln Leu Phe Arg Ile Leu Asn Pro Asn Lys 
            740                 745                 750         


Ala Pro Leu Arg Leu Lys Leu Arg Leu Thr Tyr Asp His Phe His Gln 
        755                 760                 765             


Ser Val Gln Glu Ile Phe Glu Val Asn Asn Leu Pro Val Glu Ser Trp 
    770                 775                 780                 


Gln 
785 


<210>  13
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu 
    290                 295                 300                 


Gly Phe Glu Asn Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Lys Thr Ile Val Lys Ala 
                325                 


<210>  14
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  15
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Asp Ala Thr Val Leu Arg Lys Lys Gly Tyr Ile Val Gly Ile 
1               5                   10                  15      


Asn Leu Gly Lys Gly Ser Tyr Ala Lys Val Lys Ser Ala Tyr Ser Glu 
            20                  25                  30          


Arg Leu Lys Phe Asn Val Ala Val Lys Ile Ile Asp Arg Lys Lys Thr 
        35                  40                  45              


Pro Thr Asp Phe Val Glu Arg Phe Leu Pro Arg Glu Met Asp Ile Leu 
    50                  55                  60                  


Ala Thr Val Asn His Gly Ser Ile Ile Lys Thr Tyr Glu Ile Phe Glu 
65                  70                  75                  80  


Thr Ser Asp Gly Arg Ile Tyr Ile Ile Met Glu Leu Gly Val Gln Gly 
                85                  90                  95      


Asp Leu Leu Glu Phe Ile Lys Cys Gln Gly Ala Leu His Glu Asp Val 
            100                 105                 110         


Ala Arg Lys Met Phe Arg Gln Leu Ser Ser Ala Val Lys Tyr Cys His 
        115                 120                 125             


Asp Leu Asp Ile Val His Arg Asp Leu Lys Cys Glu Asn Leu Leu Leu 
    130                 135                 140                 


Asp Lys Asp Phe Asn Ile Lys Leu Ser Asp Phe Gly Phe Ser Lys Arg 
145                 150                 155                 160 


Cys Leu Arg Asp Ser Asn Gly Arg Ile Ile Leu Ser Lys Thr Phe Cys 
                165                 170                 175     


Gly Ser Ala Ala Tyr Ala Ala Pro Glu Val Leu Gln Ser Ile Pro Tyr 
            180                 185                 190         


Gln Pro Lys Val Tyr Asp Ile Trp Ser Leu Gly Val Ile Leu Tyr Ile 
        195                 200                 205             


Met Val Cys Gly Ser Met Pro Tyr Asp Asp Ser Asp Ile Arg Lys Met 
    210                 215                 220                 


Leu Arg Ile Gln Lys Glu His Arg Val Asp Phe Pro Arg Ser Lys Asn 
225                 230                 235                 240 


Leu Thr Cys Glu Cys Lys Asp Leu Ile Tyr Arg Met Leu Gln Pro Asp 
                245                 250                 255     


Val Ser Gln Arg Leu His Ile Asp Glu Ile Leu Ser His Ser Trp Leu 
            260                 265                 270         


Gln Pro Pro Lys Pro Lys Ala Thr Ser Ser Ala Ser Phe Lys Arg Glu 
        275                 280                 285             


Gly Glu Gly Lys Tyr Arg Ala Glu Cys Lys Leu Asp Thr Lys Thr Gly 
    290                 295                 300                 


Leu Arg Pro Asp His Arg Pro Asp His Lys Leu Gly Ala Lys Thr Gln 
305                 310                 315                 320 


His Arg Leu Leu Val Val Pro Glu Asn Glu Asn Arg Met Glu Asp Arg 
                325                 330                 335     


Leu Ala Glu Thr Ser Arg Ala Lys Asp His His Ile Ser Gly Ala Glu 
            340                 345                 350         


Val Gly Lys Ala Ser Thr 
        355             


<210>  16
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Thr 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Thr Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Thr Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Thr Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Thr Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Thr Thr Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Thr Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Thr Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Thr Leu Lys 
            260                 265                 270         


Glu Gly Thr Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Thr Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Thr Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile His Phe Gly Val Phe Thr Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Thr Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Thr Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210>  17
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  18
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  19
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210>  20
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr His Met Cys Met Val Met Arg Gly Val Gln Lys Met Asn Ser Lys 
    210                 215                 220                 


Thr Val Thr Ser Thr Met Leu Gly Val Phe Arg Glu Asp Pro Lys Thr 
225                 230                 235                 240 


Arg Glu Glu Phe Leu Thr Leu Ile Arg Ser 
                245                 250 


<210>  21
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gln Ser Val Gln Ser Thr Ser Phe Cys Leu Arg Lys Gln Cys Leu 
1               5                   10                  15      


Cys Leu Thr Phe Leu Leu Leu His Leu Leu Gly Gln Val Ala Ala Thr 
            20                  25                  30          


Gln Arg Cys Pro Pro Gln Cys Pro Gly Arg Cys Pro Ala Thr Pro Pro 
        35                  40                  45              


Thr Cys Ala Pro Gly Val Arg Ala Val Leu Asp Gly Cys Ser Cys Cys 
    50                  55                  60                  


Leu Val Cys Ala Arg Gln Arg Gly Glu Ser Cys Ser Asp Leu Glu Pro 
65                  70                  75                  80  


Cys Asp Glu Ser Ser Gly Leu Tyr Cys Asp Arg Ser Ala Asp Pro Ser 
                85                  90                  95      


Asn Gln Thr Gly Ile Cys Thr Ala Val Glu Gly Asp Asn Cys Val Phe 
            100                 105                 110         


Asp Gly Val Ile Tyr Arg Ser Gly Glu Lys Phe Gln Pro Ser Cys Lys 
        115                 120                 125             


Phe Gln Cys Thr Cys Arg Asp Gly Gln Ile Gly Cys Val Pro Arg Cys 
    130                 135                 140                 


Gln Leu Asp Val Leu Leu Pro Glu Pro Asn Cys Pro Ala Pro Arg Lys 
145                 150                 155                 160 


Val Glu Val Pro Gly Glu Cys Cys Glu Lys Trp Ile Cys Gly Pro Asp 
                165                 170                 175     


Glu Glu Asp Ser Leu Gly Gly Leu Thr Leu Ala Ala Tyr Arg Pro Glu 
            180                 185                 190         


Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu 
        195                 200                 205             


Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe 
    210                 215                 220                 


Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln 
225                 230                 235                 240 


Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro 
                245                 250                 255     


Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys 
            260                 265                 270         


Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys 
        275                 280                 285             


Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His 
    290                 295                 300                 


Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile 
305                 310                 315                 320 


Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn 
                325                 330                 335     


Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr 
            340                 345                 350         


Thr Arg Gly Lys Met 
        355         


<210>  22
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ser Ser Ser Gly Ala Gly Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Asn Leu Asn Ala Val Arg Glu Thr Met Asp Val Leu Leu Glu Ile Ser 
            20                  25                  30          


Arg Ile Leu Asn Thr Gly Leu Asp Met Glu Thr Leu Ser Ile Cys Val 
        35                  40                  45              


Arg Leu Cys Glu Gln Gly Ile Asn Pro Glu Ala Leu Ser Ser Val Ile 
    50                  55                  60                  


Lys Glu Leu Arg Lys Ala Thr Glu Ala Leu Lys Ala Ala Glu Asn Met 
65                  70                  75                  80  


Thr Ser 
        


<210>  23
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Phe Asp Cys Trp Arg Phe Ile Leu Cys Lys Arg Pro Gly Ser Asn 
1               5                   10                  15      


Ser Tyr Ser Ser Pro Gln Arg Pro Asn Glu Ala Lys Lys Glu Glu Thr 
            20                  25                  30          


Asp His Gln Ile Asp Val Ser Asp Val Ile Arg Leu Val Gln Asp Thr 
        35                  40                  45              


Pro Glu Ala Thr Ala Met Ala Thr Asp Glu Ile Met His Gln Asp Ile 
    50                  55                  60                  


Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys Lys Arg Phe 
65                  70                  75                  80  


Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro Val Ile Thr 
                85                  90                  95      


Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys Glu Phe Gln 
            100                 105                 110         


Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Leu Gln Asp Ala Gly 
        115                 120                 125             


Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys Trp Thr Ser 
    130                 135                 140                 


Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro Ala Asn Leu 
145                 150                 155                 160 


Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln Arg Thr Leu 
                165                 170                 175     


Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys Met Lys Val 
            180                 185                 190         


Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly Tyr Ile Asp 
        195                 200                 205             


Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp Tyr Cys His 
    210                 215                 220                 


Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe Ala Leu Met 
225                 230                 235                 240 


Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr Glu Leu Ala 
                245                 250                 255     


Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser Val Leu Cys 
            260                 265                 270         


Ala His Thr Glu Lys Lys Asp Lys Ala Lys Glu Asp Leu Arg Leu Ala 
        275                 280                 285             


Leu Lys Glu Gly His Ser Val Leu Glu Ser Leu Arg Glu Leu Gln Ala 
    290                 295                 300                 


Glu Gly Ser Glu Pro Ser Val Asn Gln Asp Gln Leu Asp Asn Gln Ala 
305                 310                 315                 320 


Thr Val Gln Arg Leu Leu Ala Gln Leu Asn Glu Thr Glu Ala Ala Phe 
                325                 330                 335     


Asp Glu Phe Trp Ala Lys His Gln Gln Lys Leu Glu Gln Cys Leu Gln 
            340                 345                 350         


Leu Arg His Phe Glu Gln Gly Phe Arg Glu Val Lys Ala Ile Leu Asp 
        355                 360                 365             


Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly Asn Ser Leu 
    370                 375                 380                 


Ala His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe Glu Glu Lys 
385                 390                 395                 400 


Ser Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu Asp Gly Glu 
                405                 410                 415     


Gln Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile Arg Pro Lys 
            420                 425                 430         


Cys Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala Glu Ile Ala 
        435                 440                 445             


Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His Arg Arg Leu 
    450                 455                 460                 


Glu Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu Leu Ala Ser 
465                 470                 475                 480 


Gln Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu Ala Ala Leu 
                485                 490                 495     


Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn Lys Ile Gln 
            500                 505                 510         


Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu Asn Gln Asp 
        515                 520                 525             


Leu Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala Ser Met Glu 
    530                 535                 540                 


Glu Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu Ala Ala Arg 
545                 550                 555                 560 


Gln Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu Ala Leu Ala 
                565                 570                 575     


Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser Glu Asn Ser 
            580                 585                 590         


Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg Arg Ala Lys 
        595                 600                 605             


Ser Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala Gly Glu Glu 
    610                 615                 620                 


Glu Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser Glu Leu Leu 
625                 630                 635                 640 


Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val Leu Glu Gly 
                645                 650                 655     


Tyr Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu Leu Ser Thr 
            660                 665                 670         


Gly Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met Glu Glu Ile 
        675                 680                 685             


Tyr His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu Asn Tyr Thr 
    690                 695                 700                 


Asp Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg Met Glu Asp 
705                 710                 715                 720 


Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg Ser Glu Ser 
                725                 730                 735     


Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu Cys Gln Arg 
            740                 745                 750         


Lys Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu Lys Pro Val 
        755                 760                 765             


Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met Leu Lys Tyr 
    770                 775                 780                 


Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala Leu Ser Ser 
785                 790                 795                 800 


Ile Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu Ile Ala 
                805                 810                 815     


Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu Leu Met 
            820                 825                 830         


Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His Thr Lys 
        835                 840                 845             


Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu Phe Leu 
    850                 855                 860                 


His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn Gly Glu 
865                 870                 875                 880 


Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu Asn Met 
                885                 890                 895     


Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys Lys Phe 
            900                 905                 910         


Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln Ala Pro 
        915                 920                 925             


Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys Val Leu 
    930                 935                 940                 


Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg Ala Leu 
945                 950                 955                 960 


Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr Ser Pro 
                965                 970                 975     


Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg Lys Thr 
            980                 985                 990         


Asp Pro Leu Ser Leu Glu Gly Tyr  Val Ser Ser Ala Pro  Leu Thr Lys 
        995                 1000                 1005             


Pro Pro  Glu Lys Gly Lys Gly  Trp Ser Lys Thr Ser  His Ser Leu 
    1010                 1015                 1020             


Glu Ala  Pro Glu Asp Asp Gly  Gly Trp Ser Ser Ala  Glu Glu Gln 
    1025                 1030                 1035             


Ile Asn  Ser Ser Asp Ala Glu  Glu Asp Gly Gly Leu  Gly Pro Lys 
    1040                 1045                 1050             


Lys Leu  Val Pro Gly Lys Tyr  Thr Val Val Ala Asp  His Glu Lys 
    1055                 1060                 1065             


Gly Gly  Pro Asp Ala Leu Arg  Val Arg Ser Gly Asp  Val Val Glu 
    1070                 1075                 1080             


Leu Val  Gln Glu Gly Asp Glu  Gly Leu Trp Tyr Val  Arg Asp Pro 
    1085                 1090                 1095             


Thr Thr  Gly Lys Glu Gly Trp  Val Pro Ala Ser Ser  Leu Ser Val 
    1100                 1105                 1110             


Arg Leu  Gly Pro Ser Gly Ser  Ala Gln Cys Leu Ser  Ser Ser Gly 
    1115                 1120                 1125             


Lys Ala  His Val Pro Arg Ala  His Pro 
    1130                 1135         


<210>  24
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Glu Lys Pro Phe Thr Val Glu Ile Ser Pro Gly 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Gln Ile Gly Asp Ser Val Met Leu Thr Cys Ser 
                325                 330                 335     


Val Met Gly Cys Glu Ser Pro Ser Phe Ser Trp Arg Thr Gln Ile Asp 
            340                 345                 350         


Ser Pro Leu Ser Gly Lys Val Arg Ser Glu Gly Thr Asn Ser Thr Leu 
        355                 360                 365             


Thr Leu Ser Pro Val Ser Phe Glu Asn Glu His Ser Tyr Leu Cys Thr 
    370                 375                 380                 


Val Thr Cys Gly His Lys Lys Leu Glu Lys Gly Ile Gln Val Glu Leu 
385                 390                 395                 400 


Tyr Ser Phe Pro Arg Asp Pro Glu Ile Glu Met Ser Gly Gly Leu Val 
                405                 410                 415     


Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro Ser Val Tyr Pro 
            420                 425                 430         


Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu Thr Ile Leu Glu 
        435                 440                 445             


Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser Leu Glu Asn Lys 
    450                 455                 460                 


Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp Thr Gly Lys Ala 
465                 470                 475                 480 


Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met Glu Phe Glu Pro 
                485                 490                 495     


Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn Val Ala Pro Arg 
            500                 505                 510         


Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu Glu Glu Gly Ser 
        515                 520                 525             


Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro Ala Pro Lys Ile 
    530                 535                 540                 


Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln Pro Leu Ser Glu 
545                 550                 555                 560 


Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu Asp Ser Gly Val 
                565                 570                 575     


Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser Arg Lys Glu Val 
            580                 585                 590         


Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys Leu Thr Ala Phe 
        595                 600                 605             


Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile Ile Ser Cys Thr 
    610                 615                 620                 


Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys Lys Lys Ala Glu 
625                 630                 635                 640 


Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala Tyr Thr Ile Arg 
                645                 650                 655     


Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys Glu Ser Lys Asn 
            660                 665                 670         


Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp Val Gln Gly Arg 
        675                 680                 685             


Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu Val Leu Tyr Phe 
    690                 695                 700                 


Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile Ile Tyr Phe Ala 
705                 710                 715                 720 


Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val Glu Ala Gln Lys 
                725                 730                 735     


Ser Lys Val 
            


<210>  25
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Ser Gly Ile His Val Ala Leu Val Thr Gly Gly Asn Lys Gly 
1               5                   10                  15      


Ile Gly Leu Ala Ile Val Arg Asp Leu Cys Arg Leu Phe Ser Gly Asp 
            20                  25                  30          


Val Val Leu Thr Ala Arg Asp Val Thr Arg Gly Gln Ala Ala Val Gln 
        35                  40                  45              


Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile 
    50                  55                  60                  


Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu 
65                  70                  75                  80  


Tyr Gly Gly Leu Asp Val Leu Val Asn Asn Ala Gly Ile Ala Phe Lys 
                85                  90                  95      


Val Ala Asp Pro Thr Pro Phe His Ile Gln Ala Glu Val Thr Met Lys 
            100                 105                 110         


Thr Asn Phe Phe Gly Thr Arg Asp Val Cys Thr Glu Leu Leu Pro Leu 
        115                 120                 125             


Ile Lys Pro Gln Gly Arg Val Val Asn Val Ser Ser Ile Met Ser Val 
    130                 135                 140                 


Arg Ala Leu Lys Ser Cys Ser Pro Glu Leu Gln Gln Lys Phe Arg Ser 
145                 150                 155                 160 


Glu Thr Ile Thr Glu Glu Glu Leu Val Gly Leu Met Asn Lys Phe Val 
                165                 170                 175     


Glu Asp Thr Lys Lys Gly Val His Gln Lys Glu Gly Trp Pro Ser Ser 
            180                 185                 190         


Ala Tyr Gly Val Thr Lys Ile Gly Val Thr Val Leu Ser Arg Ile His 
        195                 200                 205             


Ala Arg Lys Leu Ser Glu Gln Arg Lys Gly Asp Lys Ile Leu Leu Asn 
    210                 215                 220                 


Ala Cys Cys Pro Gly Trp Val Arg Thr Asp Met Ala Gly Pro Lys Ala 
225                 230                 235                 240 


Thr Lys Ser Pro Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu 
                245                 250                 255     


Leu Pro Pro Asp Ala Glu Gly Pro His Gly Gln Phe Val Ser Glu Lys 
            260                 265                 270         


Arg Val Glu Gln Trp 
        275         


<210>  26
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Phe Ser Gly Phe Trp Tyr Ile Leu Ala 
        35                  40                  45              


Thr Ala Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys 
    50                  55                  60                  


Leu Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val 
65                  70                  75                  80  


Leu Leu Ala Phe Arg Arg Gly Gln Gly Cys Gly Arg Ala Gln Pro Arg 
                85                  90                  95      


His Pro Gly Thr Ser Gly His Leu Trp Ala Ser Leu Ser Val Lys Gly 
            100                 105                 110         


Val Lys Ala Phe His Val Leu Ser Thr Asp Tyr Ser Tyr Gly Leu Val 
        115                 120                 125             


Tyr Leu Arg Leu Gly Arg Ala Thr Gln Asn Tyr Lys Asn Leu Leu Leu 
    130                 135                 140                 


Phe His Arg Gln Asn Val Ser Ser Phe Gln Ser Leu Lys Glu Phe Met 
145                 150                 155                 160 


Asp Ala Cys Asp Ile Leu Gly Leu Ser Lys Ala Ala Val Ile Leu Pro 
                165                 170                 175     


Lys Asp Ala Ser Arg Thr His Thr Ile Leu Pro 
            180                 185         


<210>  27
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  28
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln 
1               5                   10                  15      


Val Pro Gly Met Gln Met Gly Gln Pro Val Pro Glu Thr Gly Pro Ala 
            20                  25                  30          


Ile Leu Leu Asp Gly Tyr Ser Gly Pro Ala Tyr Ser Asp Thr Tyr Ser 
        35                  40                  45              


Ser Ala Gly Asp Ser Val Tyr Thr Tyr Phe Ser Ala Val Ala Gly Gln 
    50                  55                  60                  


Asp Gly Glu Val Asp Ala Glu Glu Leu Gln Arg Cys Leu Thr Gln Ser 
65                  70                  75                  80  


Gly Ile Asn Gly Thr Tyr Ser Pro Phe Ser Leu Glu Thr Cys Arg Ile 
                85                  90                  95      


Met Ile Ala Met Leu Asp Arg Asp His Thr Gly Lys Met Gly Phe Asn 
            100                 105                 110         


Ala Phe Lys Glu Leu Trp Ala Ala Leu Asn Ala Trp Lys Glu Asn Phe 
        115                 120                 125             


Met Thr Val Asp Gln Asp Gly Ser Gly Thr Val Glu His His Glu Leu 
    130                 135                 140                 


Arg Gln Ala Ile Gly Leu Met Gly Tyr Arg Leu Ser Pro Gln Thr Leu 
145                 150                 155                 160 


Thr Thr Ile Val Lys Arg Tyr Ser Lys Asn Gly Arg Ile Phe Phe Asp 
                165                 170                 175     


Asp Tyr Val Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Phe Phe 
            180                 185                 190         


Arg Lys Arg Asp His Leu Gln Gln Gly Ser Ala Asn Phe Ile Tyr Asp 
        195                 200                 205             


Asp Phe Leu Gln Gly Thr Met Ala Ile 
    210                 215         


<210>  29
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Lys Ile Arg Ala Asn Ala Ile Ala Ile Leu Thr Val Ala Trp 
1               5                   10                  15      


Ile Leu Gly Thr Phe Tyr Tyr Leu Trp Gln Asp Asn Arg Ala His Ala 
            20                  25                  30          


Ala Ser Ser Gly Gly Arg Gly Ala Gln Arg Ala Gly Arg Arg Ser Glu 
        35                  40                  45              


Gln Leu Arg Glu Asp Arg Thr Ile Pro Leu Ile Val Thr Gly Thr Pro 
    50                  55                  60                  


Ser Lys Gly Phe Asp Glu Lys Ala Tyr Leu Ser Ala Lys Gln Leu Lys 
65                  70                  75                  80  


Ala Gly Glu Asp Pro Tyr Arg Gln His Ala Phe Asn Gln Leu Glu Ser 
                85                  90                  95      


Asp Lys Leu Ser Pro Asp Arg Pro Ile Arg Asp Thr Arg His Tyr Ser 
            100                 105                 110         


Cys Pro Ser Val Ser Tyr Ser Ser Asp Leu Pro Ala Thr Ser Val Ile 
        115                 120                 125             


Ile Thr Phe His Asn Glu Ala Arg Ser Thr Leu Leu Arg Thr Val Lys 
    130                 135                 140                 


Ser Val Leu Asn Arg Thr Pro Ala Asn Leu Ile Gln Glu Ile Ile Leu 
145                 150                 155                 160 


Val Asp Asp Phe Ser Ser Asp Pro Glu Asp Cys Leu Leu Leu Thr Arg 
                165                 170                 175     


Ile Pro Lys Val Lys Cys Leu Arg Asn Asp Arg Arg Glu Gly Leu Ile 
            180                 185                 190         


Arg Ser Arg Val Arg Gly Ala Asp Val Ala Ala Ala Thr Val Leu Thr 
        195                 200                 205             


Phe Leu Asp Ser His Cys Glu Val Asn Thr Glu Trp Leu Pro Pro Met 
    210                 215                 220                 


Leu Gln Arg Val Lys Glu Asp His Thr Arg Val Val Ser Pro Ile Ile 
225                 230                 235                 240 


Asp Val Ile Ser Leu Asp Asn Phe Ala Tyr Leu Ala Ala Ser Ala Asp 
                245                 250                 255     


Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Lys Trp Glu Gln Ile 
            260                 265                 270         


Pro Leu Glu Gln Lys Met Thr Arg Thr Asp Pro Thr Arg Pro Ile Arg 
        275                 280                 285             


Thr Pro Val Ile Ala Gly Gly Ile Phe Val Ile Asp Lys Ser Trp Phe 
    290                 295                 300                 


Asn His Leu Gly Lys Tyr Asp Ala Gln Met Asp Ile Trp Gly Gly Glu 
305                 310                 315                 320 


Asn Phe Glu Leu Ser Phe Arg Val Trp Met Cys Gly Gly Ser Leu Glu 
                325                 330                 335     


Ile Val Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Arg His Pro 
            340                 345                 350         


Tyr Asn Phe Pro Glu Gly Asn Ala Leu Thr Tyr Ile Arg Asn Thr Lys 
        355                 360                 365             


Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gln Tyr Tyr Tyr Glu 
    370                 375                 380                 


Ala Arg Pro Ser Ala Ile Gly Lys Ala Phe Gly Ser Val Ala Thr Arg 
385                 390                 395                 400 


Ile Glu Gln Arg Lys Lys Met Asn Cys Lys Ser Phe Arg Trp Tyr Leu 
                405                 410                 415     


Glu Asn Val Tyr Pro Glu Leu Thr Val Pro Val Lys Glu Ala Leu Pro 
            420                 425                 430         


Gly Ile Ile Lys Gln Gly Val Asn Cys Leu Glu Ser Gln Gly Gln Asn 
        435                 440                 445             


Thr Ala Gly Asp Phe Leu Leu Gly Met Gly Ile Cys Arg Gly Ser Ala 
    450                 455                 460                 


Lys Asn Pro Gln Pro Ala Gln Ala Trp Leu Phe Ser Asp His Leu Ile 
465                 470                 475                 480 


Gln Gln Gln Gly Lys Cys Leu Ala Ala Thr Ser Thr Leu Met Ser Ser 
                485                 490                 495     


Pro Gly Ser Pro Val Ile Leu Gln Met Cys Asn Pro Arg Glu Gly Lys 
            500                 505                 510         


Gln Lys Trp Arg Arg Lys Gly Ser Phe Ile Gln His Ser Val Ser Gly 
        515                 520                 525             


Leu Cys Leu Glu Thr Lys Pro Ala Gln Leu Val Thr Ser Lys Cys Gln 
    530                 535                 540                 


Ala Asp Ala Gln Ala Gln Gln Trp Gln Leu Leu Pro His Thr 
545                 550                 555             


<210>  30
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  31
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  32
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
1               5                   10                  15      


Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
            20                  25                  30          


Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
        35                  40                  45              


Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
    50                  55                  60                  


Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
65                  70                  75                  80  


Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                85                  90                  95      


Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 
            100                 105                 110         


Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
        115                 120                 125             


Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
    130                 135                 140                 


Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 
145                 150                 155                 160 


Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 
                165                 170                 175     


Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 
            180                 185                 190         


Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala 
        195                 200                 205             


Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 
    210                 215                 220                 


Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 
225                 230                 235                 240 


Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 
                245                 250                 255     


Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 
            260                 265                 270         


Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 
        275                 280                 285             


Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 
    290                 295                 300                 


Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 
305                 310                 315                 320 


Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 
                325                 330                 335     


Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 
            340                 345                 350         


Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 
        355                 360                 365             


His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 
    370                 375                 380                 


Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 
385                 390                 395                 400 


Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 
                405                 410                 415     


Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 
            420                 425                 430         


Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 
        435                 440                 445             


Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 
    450                 455                 460                 


Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 
465                 470                 475                 480 


Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 
                485                 490                 495     


Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 
            500                 505                 510         


Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 
        515                 520                 525             


Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 
    530                 535                 540                 


Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 
545                 550                 555                 560 


Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn 
                565                 570                 575     


Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 
            580                 585                 590         


Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 
        595                 600                 605             


Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 
    610                 615                 620                 


Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 
625                 630                 635                 640 


Thr Ser Pro Arg Leu Pro Val Phe 
                645             


<210>  33
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile 
1               5                   10                  15      


Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser 
            20                  25                  30          


Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg 
        35                  40                  45              


Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr 
    50                  55                  60                  


Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu 
65                  70                  75                  80  


Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly 
                85                  90                  95      


Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn 
            100                 105                 110         


Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu 
        115                 120                 125             


Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val 
    130                 135                 140                 


Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys 
145                 150                 155                 160 


Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser 
                165                 170                 175     


Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser 
            180                 185                 190         


Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr 
        195                 200                 205             


Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys 
    210                 215                 220                 


Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu 
225                 230                 235                 240 


Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys 
                245                 250                 255     


Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln 
            260                 265                 270         


Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn 
        275                 280                 285             


Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly 
    290                 295                 300                 


Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr 
305                 310                 315                 320 


Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp 
                325                 330                 335     


Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg 
            340                 345                 350         


Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys 
        355                 360                 365             


Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile 
    370                 375                 380                 


Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala 
385                 390                 395                 400 


His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln 
                405                 410                 415     


Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu 
            420                 425                 430         


Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly 
        435                 440                 445             


Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His 
    450                 455                 460                 


Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu 
465                 470                 475                 480 


Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp 
                485                 490                 495     


Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe 
            500                 505                 510         


Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu 
        515                 520                 525             


Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser 
    530                 535                 540                 


Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr 
545                 550                 555                 560 


Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp 
                565                 570                 575     


Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile 
            580                 585                 590         


Asp Glu Ser Pro Val Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr 
        595                 600                 605             


Leu Lys Gly Ser Arg Ala Lys His Asn 
    610                 615         


<210>  34
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Thr Thr Ser Gly Ala Leu Phe Pro Ser Leu Val Pro Gly Ser Arg 
1               5                   10                  15      


Gly Ala Ser Asn Lys Tyr Leu Val Glu Phe Arg Ala Gly Lys Met Ser 
            20                  25                  30          


Leu Lys Gly Thr Thr Val Thr Pro Asp Lys Arg Lys Gly Leu Val Tyr 
        35                  40                  45              


Ile Gln Gln Thr Asp Asp Ser Leu Ile His Phe Cys Trp Lys Asp Arg 
    50                  55                  60                  


Thr Ser Gly Asn Val Glu Asp Asp Leu Ile Ile Phe Pro Asp Asp Cys 
65                  70                  75                  80  


Glu Phe Lys Arg Val Pro Gln Cys Pro Ser Gly Arg Val Tyr Val Leu 
                85                  90                  95      


Lys Phe Lys Ala Gly Ser Lys Arg Leu Phe Phe Trp Met Gln Glu Pro 
            100                 105                 110         


Lys Thr Asp Gln Asp Glu Glu His Cys Arg Lys Val Asn Glu Tyr Leu 
        115                 120                 125             


Asn Asn Pro Pro Met Pro Gly Ala Leu Gly Ala Ser Gly Ser Ser Gly 
    130                 135                 140                 


His Glu Leu Ser Ala Leu Gly Gly Glu Gly Gly Leu Gln Ser Leu Leu 
145                 150                 155                 160 


Gly Asn Met Ser His Ser Gln Leu Met Gln Leu Ile Gly Pro Ala Gly 
                165                 170                 175     


Leu Gly Gly Leu Gly Gly Leu Gly Ala Leu Thr Gly Pro Gly Leu Ala 
            180                 185                 190         


Ser Leu Leu Gly Ser Ser Gly Pro Pro Gly Ser Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Arg Ser Gln Ser Ala Ala Val Thr Pro Ser Ser Thr Thr Ser Ser 
    210                 215                 220                 


Thr Arg Ala Thr Pro Ala Pro Ser Ala Pro Ala Ala Ala Ser Ala Thr 
225                 230                 235                 240 


Ser Pro Ser Pro Ala Pro Ser Ser Gly Asn Gly Ala Ser Thr Ala Ala 
                245                 250                 255     


Ser Pro Thr Gln Pro Ile Gln Leu Ser Asp Leu Gln Ser Ile Leu Ala 
            260                 265                 270         


Thr Met Asn Val Pro Ala Gly Pro Ala Gly Gly Gln Gln Val Asp Leu 
        275                 280                 285             


Ala Ser Val Leu Thr Pro Glu Ile Met Ala Pro Ile Leu Ala Asn Ala 
    290                 295                 300                 


Asp Val Gln Glu Arg Leu Leu Pro Tyr Leu Pro Ser Gly Glu Ser Leu 
305                 310                 315                 320 


Pro Gln Thr Ala Asp Glu Ile Gln Asn Thr Leu Thr Ser Pro Gln Phe 
                325                 330                 335     


Gln Gln Ala Leu Gly Met Phe Ser Ala Ala Leu Ala Ser Gly Gln Leu 
            340                 345                 350         


Gly Pro Leu Met Cys Gln Phe Gly Leu Pro Ala Glu Ala Val Glu Ala 
        355                 360                 365             


Ala Asn Lys Gly Asp Val Glu Ala Phe Ala Lys Ala Met Gln Asn Asn 
    370                 375                 380                 


Ala Lys Pro Glu Gln Lys Glu Gly Asp Thr Lys Asp Lys Lys Asp Glu 
385                 390                 395                 400 


Glu Glu Asp Met Ser Leu Asp 
                405         


<210>  35
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Val Asn Ala Gly Gly Val Ile Ala Tyr Ile Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ala Ser Ser Pro Ala Ser Cys His Ser Glu Gly Ser Glu Asn Ser 
            20                  25                  30          


Phe Gln Ser Ser Ser Ser Ser Val Pro Ser Ser Pro Asn Ser Ser Asn 
        35                  40                  45              


Ser Asp Thr Asn Gly Asn Pro Lys Asn Gly Asp Leu Ala Asn Ile Glu 
    50                  55                  60                  


Gly Ile Leu Lys Asn Asp Arg Ile Asp Cys Ser Met Lys Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Ala Pro Gly Met Thr Lys Ser His Ser Gly Val Thr Lys Phe 
                85                  90                  95      


Ser Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly 
            100                 105                 110         


Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg 
        115                 120                 125             


Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Lys Cys Leu Lys Asn Glu 
    130                 135                 140                 


Asn Cys Ser Ile Met Arg Met Asn Arg Asn Arg Cys Gln Gln Cys Arg 
145                 150                 155                 160 


Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe 
                165                 170                 175     


Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ile Glu Met Gln 
            180                 185                 190         


Ser Ala Met Lys Thr Met Met Asn Ser Gln Phe Ser Gly His Leu Gln 
        195                 200                 205             


Asn Asp Thr Leu Val Glu His His Glu Gln Thr Ala Leu Pro Ala Gln 
    210                 215                 220                 


Glu Gln Leu Arg Pro Lys Pro Gln Leu Glu Gln Glu Asn Ile Lys Ser 
225                 230                 235                 240 


Ser Ser Pro Pro Ser Ser Asp Phe Ala Lys Glu Glu Val Ile Gly Met 
                245                 250                 255     


Val Thr Arg Ala His Lys Asp Thr Phe Met Tyr Asn Gln Glu Gln Gln 
            260                 265                 270         


Glu Asn Ser Ala Glu Ser Met Gln Pro Gln Arg Gly Glu Arg Ile Pro 
        275                 280                 285             


Lys Asn Met Glu Gln Tyr Asn Leu Asn His Asp His Cys Gly Asn Gly 
    290                 295                 300                 


Leu Ser Ser His Phe Pro Cys Ser Glu Ser Gln Gln His Leu Asn Gly 
305                 310                 315                 320 


Gln Phe Lys Gly Arg Asn Ile Met His Tyr Pro Asn Gly His Ala Ile 
                325                 330                 335     


Cys Ile Ala Asn Gly His Cys Met Asn Phe Ser Asn Ala Tyr Thr Gln 
            340                 345                 350         


Arg Val Cys Asp Arg Val Pro Ile Asp Gly Phe Ser Gln Asn Glu Asn 
        355                 360                 365             


Lys Asn Ser Tyr Leu Cys Asn Thr Gly Gly Arg Met His Leu Val Cys 
    370                 375                 380                 


Pro Leu Ser Lys Ser Pro Tyr Val Asp Pro His Lys Ser Gly His Glu 
385                 390                 395                 400 


Ile Trp Glu Glu Phe Ser Met Ser Phe Thr Pro Ala Val Lys Glu Val 
                405                 410                 415     


Val Glu Phe Ala Lys Arg Ile Pro Gly Phe Arg Asp Leu Ser Gln His 
            420                 425                 430         


Asp Gln Val Asn Leu Leu Lys Ala Gly Thr Phe Glu Val Leu Met Val 
        435                 440                 445             


Arg Phe Ala Ser Leu Phe Asp Ala Lys Glu Arg Thr Val Thr Phe Leu 
    450                 455                 460                 


Ser Gly Lys Lys Tyr Ser Val Asp Asp Leu His Ser Met Gly Ala Gly 
465                 470                 475                 480 


Asp Leu Leu Asn Ser Met Phe Glu Phe Ser Glu Lys Leu Asn Ala Leu 
                485                 490                 495     


Gln Leu Ser Asp Glu Glu Met Ser Leu Phe Thr Ala Val Val Leu Val 
            500                 505                 510         


Ser Ala Asp Arg Ser Gly Ile Glu Asn Val Asn Ser Val Glu Ala Leu 
        515                 520                 525             


Gln Glu Thr Leu Ile Arg Ala Leu Arg Thr Leu Ile Met Lys Asn His 
    530                 535                 540                 


Pro Asn Glu Ala Ser Ile Phe Thr Lys Leu Leu Leu Lys Leu Pro Asp 
545                 550                 555                 560 


Leu Arg Ser Leu Asn Asn Met His Ser Glu Glu Leu Leu Ala Phe Lys 
                565                 570                 575     


Val His Pro 
            


<210>  36
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ser Asp His Gln Thr Gln Ala Gly Lys Pro Gln Ser Leu Asn 
1               5                   10                  15      


Pro Lys Ile Ile Ile Phe Glu Gln Glu Asn Phe Gln Gly His Ser His 
            20                  25                  30          


Glu Leu Asn Gly Pro Cys Pro Asn Leu Lys Glu Thr Gly Val Glu Lys 
        35                  40                  45              


Ala Gly Ser Val Leu Val Gln Ala Gly Pro Trp Val Gly Tyr Glu Gln 
    50                  55                  60                  


Ala Asn Cys Lys Gly Glu Gln Phe Val Phe Glu Lys Gly Glu Tyr Pro 
65                  70                  75                  80  


Arg Trp Asp Ser Trp Thr Ser Ser Arg Arg Thr Asp Ser Leu Ser Ser 
                85                  90                  95      


Leu Arg Pro Ile Lys Val Asp Ser Gln Glu His Lys Ile Ile Leu Tyr 
            100                 105                 110         


Glu Asn Pro Asn Phe Thr Gly Lys Lys Met Glu Ile Ile Asp Asp Asp 
        115                 120                 125             


Val Pro Ser Phe His Ala His Gly Tyr Gln Glu Lys Val Ser Ser Val 
    130                 135                 140                 


Arg Val Gln Ser Gly Thr Trp Val Gly Tyr Gln Tyr Pro Gly Tyr Arg 
145                 150                 155                 160 


Gly Leu Gln Tyr Leu Leu Glu Lys Gly Asp Tyr Lys Asp Ser Ser Asp 
                165                 170                 175     


Phe Gly Ala Pro His Pro Gln Val Gln Ser Val Arg Arg Ile Arg Asp 
            180                 185                 190         


Met Gln Trp His Gln Arg Gly Ala Phe His Pro Ser Asn 
        195                 200                 205 


<210>  37
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ala Asn Gly Asp Ser Pro Pro Trp Ser Pro Ala Leu Ala Ala 
1               5                   10                  15      


Glu Gly Arg Gly Ser Ser Cys Glu Val Arg Arg Glu Arg Thr Pro Glu 
            20                  25                  30          


Ala Arg Ile His Ser Val Lys Arg Tyr Pro Asp Leu Ser Pro Gly Pro 
        35                  40                  45              


Lys Gly Arg Ser Ser Ala Asp His Ala Ala Leu Asn Ser Ile Val Ser 
    50                  55                  60                  


Leu Gln Ala Ser Val Ser Phe Glu Asp Val Thr Val Asp Phe Ser Lys 
65                  70                  75                  80  


Glu Glu Trp Gln His Leu Asp Pro Ala Gln Arg Arg Leu Tyr Trp Asp 
                85                  90                  95      


Val Thr Leu Glu Asn Tyr Ser His Leu Leu Ser Val Gly Tyr Gln Ile 
            100                 105                 110         


Pro Lys Ser Glu Ala Ala Phe Lys Leu Glu Gln Gly Glu Gly Pro Trp 
        115                 120                 125             


Met Leu Glu Gly Glu Ala Pro His Gln Ser Cys Ser Gly Glu Ala Ile 
    130                 135                 140                 


Gly Lys Met Gln Gln Gln Gly Ile Pro Gly Gly Ile Phe Phe His Cys 
145                 150                 155                 160 


Glu Arg Phe Asp Gln Pro Ile Gly Glu Asp Ser Leu Cys Ser Ile Leu 
                165                 170                 175     


Glu Glu Leu Trp Gln Asp Asn Asp Gln Leu Glu Gln Arg Gln Glu Asn 
            180                 185                 190         


Gln Asn Asn Leu Leu Ser His Val Lys Val Leu Ile Lys Glu Arg Gly 
        195                 200                 205             


Tyr Glu His Lys Asn Ile Glu Lys Ile Ile His Val Thr Thr Lys Leu 
    210                 215                 220                 


Val Pro Ser Ile Lys Arg Leu His Asn Cys Asp Thr Ile Leu Lys His 
225                 230                 235                 240 


Thr Leu Asn Ser His Asn His Asn Arg Asn Ser Ala Thr Lys Asn Leu 
                245                 250                 255     


Gly Lys Ile Phe Gly Asn Gly Asn Asn Phe Pro His Ser Pro Ser Ser 
            260                 265                 270         


Thr Lys Asn Glu Asn Ala Lys Thr Gly Ala Asn Ser Cys Glu His Asp 
        275                 280                 285             


His Tyr Glu Lys His Leu Ser His Lys Gln Ala Pro Thr His His Gln 
    290                 295                 300                 


Lys Ile His Pro Glu Glu Lys Leu Tyr Val Cys Thr Glu Cys Val Met 
305                 310                 315                 320 


Gly Phe Thr Gln Lys Ser His Leu Phe Glu His Gln Arg Ile His Ala 
                325                 330                 335     


Gly Glu Lys Ser Arg Glu Cys Asp Lys Ser Asn Lys Val Phe Pro Gln 
            340                 345                 350         


Lys Pro Gln Val Asp Val His Pro Ser Val Tyr Thr Gly Glu Lys Pro 
        355                 360                 365             


Tyr Leu Cys Thr Gln Cys Gly Lys Val Phe Thr Leu Lys Ser Asn Leu 
    370                 375                 380                 


Ile Thr His Gln Lys Ile His Thr Gly Gln Lys Pro Tyr Lys Cys Ser 
385                 390                 395                 400 


Glu Cys Gly Lys Ala Phe Phe Gln Arg Ser Asp Leu Phe Arg His Leu 
                405                 410                 415     


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys 
            420                 425                 430         


Gly Phe Ser Gln Asn Ser Asp Leu Ser Ile His Gln Lys Thr His Thr 
        435                 440                 445             


Gly Glu Lys His Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Thr Arg 
    450                 455                 460                 


Lys Ser Ala Leu Arg Met His Gln Arg Ile His Thr Gly Glu Lys Pro 
465                 470                 475                 480 


Tyr Val Cys Ala Asp Cys Gly Lys Ala Phe Ile Gln Lys Ser His Phe 
                485                 490                 495     


Asn Thr His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser 
            500                 505                 510         


Asp Cys Gly Lys Ser Phe Thr Lys Lys Ser Gln Leu His Val His Gln 
        515                 520                 525             


Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Thr Glu Cys Gly Lys 
    530                 535                 540                 


Val Phe Thr His Arg Thr Asn Leu Thr Thr His Gln Lys Thr His Thr 
545                 550                 555                 560 


Gly Glu Lys Pro Tyr Met Cys Ala Glu Cys Gly Lys Ala Phe Thr Asp 
                565                 570                 575     


Gln Ser Asn Leu Ile Lys His Gln Lys Thr His Thr Gly Glu Lys Pro 
            580                 585                 590         


Tyr Lys Cys Asn Gly Cys Gly Lys Ala Phe Ile Trp Lys Ser Arg Leu 
        595                 600                 605             


Lys Ile His Gln Lys Ser His Ile Gly Glu Arg His Tyr Glu Cys Lys 
    610                 615                 620                 


Asp Cys Gly Lys Ala Phe Ile Gln Lys Ser Thr Leu Ser Val His Gln 
625                 630                 635                 640 


Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Pro Glu Cys Gly Lys 
                645                 650                 655     


Ala Phe Ile Gln Lys Ser His Phe Ile Ala His His Arg Ile His Thr 
            660                 665                 670         


Gly Glu Lys Pro Tyr Glu Cys Ser Asp Cys Gly Lys Cys Phe Thr Lys 
        675                 680                 685             


Lys Ser Gln Leu Arg Val His Gln Lys Ile His Thr Gly Glu Lys Pro 
    690                 695                 700                 


Asn Ile Cys Ala Glu Cys Gly Lys Ala Phe Thr Asp Arg Ser Asn Leu 
705                 710                 715                 720 


Ile Thr His Gln Lys Ile His Thr Arg Glu Lys Pro Tyr Glu Cys Gly 
                725                 730                 735     


Asp Cys Gly Lys Thr Phe Thr Trp Lys Ser Arg Leu Asn Ile His Gln 
            740                 745                 750         


Lys Ser His Thr Gly Glu Arg His Tyr Glu Cys Ser Lys Cys Gly Lys 
        755                 760                 765             


Ala Phe Ile Gln Lys Ala Thr Leu Ser Met His Gln Ile Ile His Thr 
    770                 775                 780                 


Gly Lys Lys Pro Tyr Ala Cys Thr Glu Cys Gln Lys Ala Phe Thr Asp 
785                 790                 795                 800 


Arg Ser Asn Leu Ile Lys His Gln Lys Met His Ser Gly Glu Lys Arg 
                805                 810                 815     


Tyr Lys Ala Ser Asp 
            820     


<210>  38
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Pro Ser Val Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Arg 
1               5                   10                  15      


Glu Gln Gly Asn Gly His Ile Ile Ser Trp Thr Ser Arg Asp Gly Gly 
            20                  25                  30          


Glu Phe Lys Leu Val Asp Ala Glu Glu Val Ala Arg Leu Trp Gly Leu 
        35                  40                  45              


Arg Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile Arg Lys Val Ser Gly Gln Lys 
65                  70                  75                  80  


Phe Val Tyr Lys Phe Val Ser Tyr Pro Glu Val Ala Gly Cys Ser Thr 
                85                  90                  95      


Glu Asp Cys Pro Pro Gln Pro Glu Val Ser Val Thr Ser Thr Met Pro 
            100                 105                 110         


Asn Val Ala Pro Ala Ala Ile His Ala Ala Pro Gly Asp Thr Val Ser 
        115                 120                 125             


Gly Lys Pro Gly Thr Pro Lys Gly Ala Gly Met Ala Gly Pro Gly Gly 
    130                 135                 140                 


Leu Ala Arg Ser Ser Arg Asn Glu Tyr Met Arg Ser Gly Leu Tyr Ser 
145                 150                 155                 160 


Thr Phe Thr Ile Gln Ser Leu Gln Pro Gln Pro Pro Pro His Pro Arg 
                165                 170                 175     


Pro Ala Val Val Leu Pro Ser Ala Ala Pro Ala Gly Ala Ala Ala Pro 
            180                 185                 190         


Pro Ser Gly Ser Arg Ser Thr Ser Pro Ser Pro Leu Glu Ala Cys Leu 
        195                 200                 205             


Glu Ala Glu Glu Ala Gly Leu Pro Leu Gln Val Ile Leu Thr Pro Pro 
    210                 215                 220                 


Glu Ala Pro Asn Leu Lys Ser Glu Glu Leu Asn Val Glu Pro Gly Leu 
225                 230                 235                 240 


Gly Arg Ala Leu Pro Pro Glu Val Lys Val Glu Gly Pro Lys Glu Glu 
                245                 250                 255     


Leu Glu Val Ala Gly Glu Arg Gly Phe Val Pro Glu Thr Thr Lys Ala 
            260                 265                 270         


Glu Pro Glu Val Pro Pro Gln Glu Gly Val Pro Ala Arg Leu Pro Ala 
        275                 280                 285             


Val Val Met Asp Thr Ala Gly Gln Ala Gly Gly His Ala Ala Ser Ser 
    290                 295                 300                 


Pro Glu Ile Ser Gln Pro Gln Lys Gly Arg Lys Pro Arg Asp Leu Glu 
305                 310                 315                 320 


Leu Pro Leu Ser Pro Ser Leu Leu Gly Gly Pro Gly Pro Glu Arg Thr 
                325                 330                 335     


Pro Gly Ser Gly Ser Gly Ser Gly Leu Gln Ala Pro Gly Pro Ala Leu 
            340                 345                 350         


Thr Pro Ser Leu Leu Pro Thr His Thr Leu Thr Pro Val Leu Leu Thr 
        355                 360                 365             


Pro Ser Ser Leu Pro Pro Ser Ile His Phe Trp Ser Thr Leu Ser Pro 
    370                 375                 380                 


Ile Ala Pro Arg Ser Pro Ala Lys Leu Ser Phe Gln Phe Pro Ser Ser 
385                 390                 395                 400 


Gly Ser Ala Gln Val His Ile Pro Ser Ile Ser Val Asp Gly Leu Ser 
                405                 410                 415     


Thr Pro Val Val Leu Ser Pro Gly Pro Gln Lys Pro 
            420                 425             


<210>  39
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  40
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
            180                 185                 190         


Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
        195                 200                 205             


Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
    210                 215                 220                 


Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
225                 230                 235                 240 


Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                245                 250                 255     


Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
            260                 265                 270         


Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
        275                 280                 285             


Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
    290                 295                 300                 


Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
305                 310                 315                 320 


Ile Pro Cys Ala Pro 
                325 


<210>  41
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Gly Ser Lys Thr Ser Asn Asn Ser Thr Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Thr Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr 
        35                  40                  45              


Thr Ala Gln Ala Lys Pro Gly Glu Thr Gln Glu Glu Glu Thr Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Thr Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn Ser 
                85                  90                  95      


Phe Thr Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn Leu 
            100                 105                 110         


Ser Arg Arg Leu Lys Val Thr Gly Asp Leu Phe Asp Ile Met Ser Gly 
        115                 120                 125             


Gln Thr Asp Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Thr Leu 
    130                 135                 140                 


Leu Asp Gln Leu Asp Thr Gln Leu Asn Val Thr Glu Asn Glu Cys Gln 
145                 150                 155                 160 


Asn Tyr Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp 
                165                 170                 175     


Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu 
            180                 185                 190         


Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys Ile Val 
        195                 200                 205             


Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln 
    210                 215                 220                 


Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln 
225                 230                 235                 240 


Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Met Arg Tyr 
                245                 250                 255     


Ala Gln Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala 
            260                 265                 270         


Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr Ile Asn Asn Phe 
        275                 280                 285             


Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn 
    290                 295                 300                 


Ala Ala Trp Gly Gln Thr Val Leu Leu Leu His Ala Leu Ala Asn Lys 
305                 310                 315                 320 


Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His 
                325                 330                 335     


Ser Tyr Leu Glu Ser Leu Thr Asp Lys Ser Lys Glu Leu Pro Leu Tyr 
            340                 345                 350         


Cys Ser Gly Gly Leu Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala 
        355                 360                 365             


Met Val Ala Phe Leu Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu 
    370                 375                 380                 


Lys Gly Glu Thr Arg Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys 
385                 390                 395                 400 


Gly Lys Ile Glu Asp Thr Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys 
                405                 410                 415     


Thr Gln Phe Asn Ser Glu Glu Gln Trp Thr Lys Ala Leu Lys Phe Met 
            420                 425                 430         


Leu Thr Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr 
        435                 440                 445             


Asn Lys 
    450 


<210>  42
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Pro Pro Leu Pro Val Gly Ala Gln Pro Leu Ala Thr Val Glu 
1               5                   10                  15      


Gly Met Glu Met Lys Gly Pro Leu Arg Glu Pro Cys Ala Leu Thr Leu 
            20                  25                  30          


Ala Gln Arg Asn Gly Gln Tyr Glu Leu Ile Ile Gln Leu His Glu Lys 
        35                  40                  45              


Glu Gln His Val Gln Asp Ile Ile Pro Ile Asn Ser His Phe Arg Cys 
    50                  55                  60                  


Val Gln Glu Ala Glu Glu Thr Leu Leu Ile Asp Ile Ala Ser Asn Ser 
65                  70                  75                  80  


Gly Cys Lys Ile Arg Val Gln Gly Asp Trp Ile Arg Glu Arg Arg Phe 
                85                  90                  95      


Glu Ile Pro Asp Glu Glu His Cys Leu Lys Phe Leu Ser Ala Val Leu 
            100                 105                 110         


Ala Ala Gln Lys Ala Gln Ser Gln Leu Leu Val Pro Glu Gln Lys Asp 
        115                 120                 125             


Ser Ser Ser Trp Tyr Gln Lys Leu Asp Thr Lys Asp Lys Pro Ser Val 
    130                 135                 140                 


Phe Ser Gly Leu Leu Gly Phe Glu Asp Asn Phe Ser Ser Met Asn Leu 
145                 150                 155                 160 


Asp Lys Lys Ile Asn Ser Gln Asn Gln Pro Thr Gly Ile His Arg Glu 
                165                 170                 175     


Pro Pro Pro Pro Pro Phe Ser Val Asn Lys Met Leu Pro Arg Glu Lys 
            180                 185                 190         


Glu Ala Ser Asn Lys Glu Gln Pro Lys Val Thr Asn Thr Met Arg Lys 
        195                 200                 205             


Leu Phe Val Pro Asn Thr Gln Ser Gly Gln Arg Glu Gly Leu Ile Lys 
    210                 215                 220                 


His Ile Leu Ala Lys Arg Glu Lys Glu Tyr Val Asn Ile Gln Thr Phe 
225                 230                 235                 240 


Arg Phe Phe Val Gly Thr Trp Asn Val Asn Gly Gln Ser Pro Asp Ser 
                245                 250                 255     


Gly Leu Glu Pro Trp Leu Asn Cys Asp Pro Asn Pro Pro Asp Ile Tyr 
            260                 265                 270         


Cys Ile Gly Phe Gln Glu Leu Asp Leu Ser Thr Glu Ala Phe Phe Tyr 
        275                 280                 285             


Phe Glu Ser Val Lys Glu Gln Glu Trp Ser Met Ala Val Glu Arg Gly 
    290                 295                 300                 


Leu His Ser Lys Ala Lys Tyr Lys Lys Val Gln Leu Val Arg Leu Val 
305                 310                 315                 320 


Gly Met Met Leu Leu Ile Phe Ala Arg Lys Asp Gln Cys Arg Tyr Ile 
                325                 330                 335     


Arg Asp Ile Ala Thr Glu Thr Val Gly Thr Gly Ile Met Gly Lys Met 
            340                 345                 350         


Gly Asn Lys Gly Gly Val Ala Val Arg Phe Val Phe His Asn Thr Thr 
        355                 360                 365             


Phe Cys Ile Val Asn Ser His Leu Ala Ala His Val Glu Asp Phe Glu 
    370                 375                 380                 


Arg Arg Asn Gln Asp Tyr Lys Asp Ile Cys Ala Arg Met Ser Phe Val 
385                 390                 395                 400 


Val Pro Asn Gln Thr Leu Pro Gln Leu Asn Ile Met Lys His Glu Val 
                405                 410                 415     


Val Ile Trp Leu Gly Asp Leu Asn Tyr Arg Leu Cys Met Pro Asp Ala 
            420                 425                 430         


Asn Glu Val Lys Ser Leu Ile Asn Lys Lys Asp Leu Gln Arg Leu Leu 
        435                 440                 445             


Lys Phe Asp Gln Leu Asn Ile Gln Arg Thr Gln Lys Lys Ala Phe Val 
    450                 455                 460                 


Asp Phe Asn Glu Gly Glu Ile Lys Phe Ile Pro Thr Tyr Lys Tyr Asp 
465                 470                 475                 480 


Ser Lys Thr Asp Arg Trp Asp Ser Ser Gly Lys Cys Arg Val Pro Ala 
                485                 490                 495     


Trp Cys Asp Arg Ile Leu Trp Arg Gly Thr Asn Val Asn Gln Leu Asn 
            500                 505                 510         


Tyr Arg Ser His Met Glu Leu Lys Thr Ser Asp His Lys Pro Val Ser 
        515                 520                 525             


Ala Leu Phe His Ile Gly Val Lys Val Val Asp Glu Arg Arg Tyr Arg 
    530                 535                 540                 


Lys Val Phe Glu Asp Ser Val Arg Ile Met Asp Arg Met Glu Asn Asp 
545                 550                 555                 560 


Phe Leu Pro Ser Leu Glu Leu Ser Arg Arg Glu Phe Val Phe Glu Asn 
                565                 570                 575     


Val Lys Phe Arg Gln Leu Gln Lys Glu Lys Phe Gln Ile Ser Asn Asn 
            580                 585                 590         


Gly Gln Val Pro Cys His Phe Ser Phe Ile Pro Lys Leu Asn Asp Ser 
        595                 600                 605             


Gln Tyr Cys Lys Pro Trp Leu Arg Ala Glu Pro Phe Glu Gly Tyr Leu 
    610                 615                 620                 


Glu Pro Asn Glu Thr Val Asp Ile Ser Leu Asp Val Tyr Val Ser Lys 
625                 630                 635                 640 


Asp Ser Val Thr Ile Leu Asn Ser Gly Glu Asp Lys Ile Glu Asp Ile 
                645                 650                 655     


Leu Val Leu His Leu Asp Arg Gly Lys Asp Tyr Phe Leu Thr Ile Ser 
            660                 665                 670         


Gly Asn Tyr Leu Pro Ser Cys Phe Gly Thr Ser Leu Glu Ala Leu Cys 
        675                 680                 685             


Arg Met Lys Arg Pro Ile Arg Glu Val Pro Val Thr Lys Leu Ile Asp 
    690                 695                 700                 


Leu Glu Glu Asp Ser Phe Leu Glu Lys Glu Lys Ser Leu Leu Gln Met 
705                 710                 715                 720 


Val Pro Leu Asp Glu Gly Ala Ser Glu Arg Pro Leu Gln Val Pro Lys 
                725                 730                 735     


Glu Ile Trp Leu Leu Val Asp His Leu Phe Lys Tyr Ala Cys His Gln 
            740                 745                 750         


Glu Asp Leu Phe Gln Thr Pro Gly Met Gln Glu Glu Leu Gln Gln Ile 
        755                 760                 765             


Ile Asp Cys Leu Asp Thr Ser Ile Pro Glu Thr Ile Pro Gly Ser Asn 
    770                 775                 780                 


His Ser Val Ala Glu Ala Leu Leu Ile Phe Leu Glu Ala Leu Pro Glu 
785                 790                 795                 800 


Pro Val Ile Cys Tyr Glu Leu Tyr Gln Arg Cys Leu Asp Ser Ala Tyr 
                805                 810                 815     


Asp Pro Arg Ile Cys Arg Gln Val Ile Ser Gln Leu Pro Arg Cys His 
            820                 825                 830         


Arg Asn Val Phe Arg Tyr Leu Met Ala Phe Leu Arg Glu Leu Leu Lys 
        835                 840                 845             


Phe Ser Glu Tyr Asn Ser Val Asn Ala Asn Met Ile Ala Thr Leu Phe 
    850                 855                 860                 


Thr Ser Leu Leu Leu Arg Pro Pro Pro Asn Leu Met Ala Arg Gln Thr 
865                 870                 875                 880 


Pro Ser Asp Arg Gln Arg Ala Ile Gln Phe Leu Leu Gly Phe Leu Leu 
                885                 890                 895     


Gly Ser Glu Glu Asp 
            900     


<210>  43
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Asp Tyr Gln Ala Ala Glu Glu Thr Ala Phe Val Val Asp Glu 
1               5                   10                  15      


Val Ser Asn Ile Val Lys Glu Ala Ile Glu Ser Ala Ile Gly Gly Asn 
            20                  25                  30          


Ala Tyr Gln His Ser Lys Val Asn Gln Trp Thr Thr Asn Val Val Glu 
        35                  40                  45              


Gln Thr Leu Ser Gln Leu Thr Lys Leu Gly Lys Pro Phe Lys Tyr Ile 
    50                  55                  60                  


Val Thr Cys Val Ile Met Gln Lys Asn Gly Ala Gly Leu His Thr Ala 
65                  70                  75                  80  


Ser Ser Cys Phe Trp Asp Ser Ser Thr Asp Gly Ser Cys Thr Val Arg 
                85                  90                  95      


Trp Glu Asn Lys Thr Met Tyr Cys Ile Val Ser Ala Phe Gly Leu Ser 
            100                 105                 110         


Ile 
    


<210>  44
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  45
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Pro Leu Lys Met Leu Ala Leu Val Thr Leu Leu Leu Gly Ala 
1               5                   10                  15      


Ser Leu Gln His Ile His Ala Ala Arg Gly Thr Asn Val Gly Arg Glu 
            20                  25                  30          


Cys Cys Leu Glu Tyr Phe Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys 
        35                  40                  45              


Thr Trp Tyr Gln Thr Ser Glu Asp Cys Ser Arg Asp Ala Ile Val Phe 
    50                  55                  60                  


Val Thr Val Gln Gly Arg Ala Ile Cys Ser Asp Pro Asn Asn Lys Arg 
65                  70                  75                  80  


Val Lys Asn Ala Val Lys Tyr Leu Gln Ser Leu Glu Arg Ser 
                85                  90                  


<210>  46
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Phe Tyr Phe His Cys Pro Pro Gln Leu Glu Gly Thr Ala Thr Phe 
1               5                   10                  15      


Gly Asn His Ser Ser Gly Asp Phe Asp Asp Gly Phe Leu Arg Arg Lys 
            20                  25                  30          


Gln Arg Arg Asn Arg Thr Thr Phe Thr Leu Gln Gln Leu Glu Ala Leu 
        35                  40                  45              


Glu Ala Val Phe Ala Gln Thr His Tyr Pro Asp Val Phe Thr Arg Glu 
    50                  55                  60                  


Glu Leu Ala Met Lys Ile Asn Leu Thr Glu Ala Arg Val Gln Val Trp 
65                  70                  75                  80  


Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Thr Glu Arg Gly Ala Ser 
                85                  90                  95      


Asp Gln Glu Pro Gly Ala Lys Glu Pro Met Ala Glu Val Thr Pro Pro 
            100                 105                 110         


Pro Val Arg Asn Ile Asn Ser Pro Pro Pro Gly Asp Gln Ala Arg Ser 
        115                 120                 125             


Lys Lys Glu Ala Leu Glu Ala Gln Gln Ser Leu Gly Arg Thr Val Gly 
    130                 135                 140                 


Pro Ala Gly Pro Phe Phe Pro Ser Cys Leu Pro Gly Thr Leu Leu Asn 
145                 150                 155                 160 


Thr Ala Thr Tyr Ala Gln Ala Leu Ser His Val Ala Ser Leu Lys Gly 
                165                 170                 175     


Gly Pro Leu Cys Ser Cys Cys Val Pro Asp Pro Met Gly Leu Ser Phe 
            180                 185                 190         


Leu Pro Thr Tyr Gly Cys Gln Ser Asn Arg Thr Ala Ser Val Ala Thr 
        195                 200                 205             


Leu Arg Met Lys Ala Arg Glu His Ser Glu Ala Val Leu Gln Ser Ala 
    210                 215                 220                 


Asn Leu Leu Pro Ser Thr Ser Ser Ser Pro Gly Pro Val Ala Lys Pro 
225                 230                 235                 240 


Ala Pro Pro Asp Gly Ser Gln Glu Lys Thr Ser Pro Thr Lys Glu Gln 
                245                 250                 255     


Ser Glu Ala Glu Lys Ser Val 
            260             


<210>  47
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys 
        35                  40                  45              


Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr 
    50                  55                  60                  


Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly 
65                  70                  75                  80  


Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu 
                85                  90                  95      


Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys 
            100                 105                 110         


Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly 
        115                 120                 125             


Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala 
    130                 135                 140                 


Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser 
                165                 170                 175     


Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly 
            180                 185                 190         


Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys 
        195                 200                 205             


Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met 
    210                 215                 220                 


Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala 
225                 230                 235                 240 


Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu 
                245                 250                 255     


Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe 
            260                 265         


<210>  48
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly Pro Phe 
1               5                   10                  15      


Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser Val Leu 
            20                  25                  30          


Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser Gly Lys 
        35                  40                  45              


Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser Val Thr 
    50                  55                  60                  


Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val Ile Trp 
65                  70                  75                  80  


Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu Asn Val 
                85                  90                  95      


Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr Lys Trp 
            100                 105                 110         


Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala Gly Ser 
        115                 120                 125             


Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr Glu Glu 
    130                 135                 140                 


Glu Phe Thr Leu Phe Val Tyr Glu Gln Leu Gln Glu Pro Gln Val Thr 
145                 150                 155                 160 


Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile Thr Leu 
                165                 170                 175     


Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser Trp Thr 
            180                 185                 190         


Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile Leu Thr 
        195                 200                 205             


Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys Thr Ala 
    210                 215                 220                 


Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val Gly Gln 
225                 230                 235                 240 


Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Gly Thr Thr Gly Glu Thr 
                245                 250                 255     


Val Val Gly Val Leu Gly Glu Pro Val Thr Leu Pro Leu Ala Leu Pro 
            260                 265                 270         


Ala Cys Arg Asp Thr Glu Lys Val Val Trp Leu Phe Asn Thr Ser Ile 
        275                 280                 285             


Ile Ser Lys Glu Arg Glu Glu Ala Ala Thr Ala Asp Pro Leu Ile Lys 
    290                 295                 300                 


Ser Arg Asp Pro Tyr Lys Asn Arg Val Trp Val Ser Ser Gln Asp Cys 
305                 310                 315                 320 


Ser Leu Lys Ile Ser Gln Leu Lys Ile Glu Asp Ala Gly Pro Tyr His 
                325                 330                 335     


Ala Tyr Val Cys Ser Glu Ala Ser Ser Val Thr Ser Met Thr His Val 
            340                 345                 350         


Thr Leu Leu Ile Tyr Arg Arg Leu Arg Lys Pro Lys Ile Thr Trp Ser 
        355                 360                 365             


Leu Arg His Ser Glu Asp Gly Ile Cys Arg Ile Ser Leu Thr Cys Ser 
    370                 375                 380                 


Val Glu Asp Gly Gly Asn Thr Val Met Tyr Thr Trp Thr Pro Leu Gln 
385                 390                 395                 400 


Lys Glu Ala Val Val Ser Gln Gly Glu Ser His Leu Asn Val Ser Trp 
                405                 410                 415     


Arg Ser Ser Glu Asn His Pro Asn Leu Thr Cys Thr Ala Ser Asn Pro 
            420                 425                 430         


Val Ser Arg Ser Ser His Gln Phe Leu Ser Glu Asn Ile Cys Ser Gly 
        435                 440                 445             


Pro Glu Arg Asn Thr Lys Leu Trp Ile Gly Leu Phe Leu Met Val Cys 
    450                 455                 460                 


Leu Leu Cys Val Gly Ile Phe Ser Trp Cys Ile Trp Lys Arg Lys Gly 
465                 470                 475                 480 


Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala 
                485                 490                 495     


Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr Ser Val Leu Ser 
            500                 505                 510         


Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln 
        515                 520                 525             


Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu 
    530                 535                 540                 


Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile Ser Gly Arg Tyr 
545                 550                 555                 560 


Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly His Asp Pro Ala 
                565                 570                 575     


Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu 
            580                 585                 590         


Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala Gln Val Phe Asn 
        595                 600                 605             


Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu Ser Ser Ala Thr 
    610                 615                 620                 


Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro Pro Pro Gln Gln 
625                 630                 635                 640 


Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu Asn Phe Thr 
                645                 650                 655 


<210>  49
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Arg Glu Leu Val Asn Ile Pro Leu Val His Ile Leu Thr Leu Val 
1               5                   10                  15      


Ala Phe Ser Gly Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr 
            20                  25                  30          


Pro Leu Glu Thr Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met 
        35                  40                  45              


Cys Ala Val Glu Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn 
    50                  55                  60                  


Lys Ile Leu Ile Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn 
65                  70                  75                  80  


Gly Gln Leu Leu Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile 
                85                  90                  95      


Tyr Cys Cys Thr Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys 
            100                 105                 110         


Gly Ala Leu Gln Val Lys Met Lys Pro Lys Ile Thr Arg Pro Pro Ile 
        115                 120                 125             


Asn Val Lys Ile Ile Glu Gly Leu Lys Ala Val Leu Pro Cys Thr Thr 
    130                 135                 140                 


Met Gly Asn Pro Lys Pro Ser Val Ser Trp Ile Lys Gly Asp Ser Pro 
145                 150                 155                 160 


Leu Arg Glu Asn Ser Arg Ile Ala Val Leu Glu Ser Gly Ser Leu Arg 
                165                 170                 175     


Ile His Asn Val Gln Lys Glu Asp Ala Gly Gln Tyr Arg Cys Val Ala 
            180                 185                 190         


Lys Asn Ser Leu Gly Thr Ala Tyr Ser Lys Val Val Lys Leu Glu Val 
        195                 200                 205             


Glu Val Phe Ala Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr 
    210                 215                 220                 


Phe Gly Ser Phe Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val 
225                 230                 235                 240 


Pro Thr Ile Thr Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser 
                245                 250                 255     


Ile Gln Glu Ser Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu 
            260                 265                 270         


Phe Ile Thr Lys Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His 
        275                 280                 285             


Gly Glu Lys Phe Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala 
    290                 295                 300                 


Glu Trp Ser Lys Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala Gln Tyr 
305                 310                 315                 320 


Arg Gly Glu Val Cys Asn Ala Val Leu Ala Lys Asp Ala Leu Val Phe 
                325                 330                 335     


Leu Asn Thr Ser Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu Leu Val 
            340                 345                 350         


His Thr Ala Trp Asn Glu Leu Lys Val Val Ser Pro Val Cys Arg Pro 
        355                 360                 365             


Ala Ala Glu Ala Leu Leu Cys Asn His Ile Phe Gln Glu Cys Ser Pro 
    370                 375                 380                 


Gly Val Val Pro Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys Leu Ala 
385                 390                 395                 400 


Val Lys Glu Leu Phe Cys Ala Lys Glu Trp Leu Val Met Glu Glu Lys 
                405                 410                 415     


Thr His Arg Gly Leu Tyr Arg Ser Glu Met His Leu Leu Ser Val Pro 
            420                 425                 430         


Glu Cys Ser Lys Leu Pro Ser Met His Trp Asp Pro Thr Ala Cys Ala 
        435                 440                 445             


Arg Leu Pro His Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr Phe Pro 
    450                 455                 460                 


Pro Met Thr Ser Ser Lys Pro Ser Val Asp Ile Pro Asn Leu Pro Ser 
465                 470                 475                 480 


Ser Ser Ser Ser Ser Phe Ser Val Ser Pro Thr Tyr Ser Met Thr Val 
                485                 490                 495     


Ile Ile Ser Ile Met Ser Ser Phe Ala Ile Phe Val Leu Leu Thr Ile 
            500                 505                 510         


Thr Thr Leu Tyr Cys Cys Arg Arg Arg Lys Gln Trp Lys Asn Lys Lys 
        515                 520                 525             


Arg Glu Ser Ala Ala Val Thr Leu Thr Thr Leu Pro Ser Glu Leu Leu 
    530                 535                 540                 


Leu Asp Arg Leu His Pro Asn Pro Met Tyr Gln Arg Met Pro Leu Leu 
545                 550                 555                 560 


Leu Asn Pro Lys Leu Leu Ser Leu Glu Tyr Pro Arg Asn Asn Ile Glu 
                565                 570                 575     


Tyr Val Arg Asp Ile Gly Glu Gly Ala Phe Gly Arg Val Phe Gln Ala 
            580                 585                 590         


Arg Ala Pro Gly Leu Leu Pro Tyr Glu Pro Phe Thr Met Val Ala Val 
        595                 600                 605             


Lys Met Leu Lys Glu Glu Ala Ser Ala Asp Met Gln Ala Asp Phe Gln 
    610                 615                 620                 


Arg Glu Ala Ala Leu Met Ala Glu Phe Asp Asn Pro Asn Ile Val Lys 
625                 630                 635                 640 


Leu Leu Gly Val Cys Ala Val Gly Lys Pro Met Cys Leu Leu Phe Glu 
                645                 650                 655     


Tyr Met Ala Tyr Gly Asp Leu Asn Glu Phe Leu Arg Ser Met Ser Pro 
            660                 665                 670         


His Thr Val Cys Ser Leu Ser His Ser Asp Leu Ser Met Arg Ala Gln 
        675                 680                 685             


Val Ser Ser Pro Gly Pro Pro Pro Leu Ser Cys Ala Glu Gln Leu Cys 
    690                 695                 700                 


Ile Ala Arg Gln Val Ala Ala Gly Met Ala Tyr Leu Ser Glu Arg Lys 
705                 710                 715                 720 


Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn 
                725                 730                 735     


Met Val Val Lys Ile Ala Asp Phe Gly Leu Ser Arg Asn Ile Tyr Ser 
            740                 745                 750         


Ala Asp Tyr Tyr Lys Ala Asn Glu Asn Asp Ala Ile Pro Ile Arg Trp 
        755                 760                 765             


Met Pro Pro Glu Ser Ile Phe Tyr Asn Arg Tyr Thr Thr Glu Ser Asp 
    770                 775                 780                 


Val Trp Ala Tyr Gly Val Val Leu Trp Glu Ile Phe Ser Tyr Gly Leu 
785                 790                 795                 800 


Gln Pro Tyr Tyr Gly Met Ala His Glu Glu Val Ile Tyr Tyr Val Arg 
                805                 810                 815     


Asp Gly Asn Ile Leu Ser Cys Pro Glu Asn Cys Pro Val Glu Leu Tyr 
            820                 825                 830         


Asn Leu Met Arg Leu Cys Trp Ser Lys Leu Pro Ala Asp Arg Pro Ser 
        835                 840                 845             


Phe Thr Ser Ile His Arg Ile Leu Glu Arg Met Cys Glu Arg Ala Glu 
    850                 855                 860                 


Gly Thr Val Ser Val 
865                 


<210>  50
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Arg Pro Ala Val Leu Gly Ser Pro Asp Arg Ala Pro Pro Glu Asp 
1               5                   10                  15      


Glu Gly Pro Val Met Val Lys Leu Glu Asp Ser Glu Glu Glu Gly Glu 
            20                  25                  30          


Ala Ala Leu Trp Asp Pro Gly Pro Glu Ala Ala Arg Leu Arg Phe Arg 
        35                  40                  45              


Cys Phe Arg Tyr Glu Glu Ala Thr Gly Pro Gln Glu Ala Leu Ala Gln 
    50                  55                  60                  


Leu Arg Glu Leu Cys Arg Gln Trp Leu Arg Pro Glu Val Arg Ser Lys 
65                  70                  75                  80  


Glu Gln Met Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Gly Ala Leu 
                85                  90                  95      


Pro Pro Glu Ile Gln Ala Arg Val Gln Gly Gln Arg Pro Gly Ser Pro 
            100                 105                 110         


Glu Glu Ala Ala Ala Leu Val Asp Gly Leu Arg Arg Glu Pro Gly Gly 
        115                 120                 125             


Pro Arg Arg Trp Val Thr Val Gln Val Gln Gly Gln Glu Val Leu Ser 
    130                 135                 140                 


Glu Lys Met Glu Pro Ser Ser Phe Gln Pro Leu Pro Glu Thr Glu Pro 
145                 150                 155                 160 


Pro Thr Pro Glu Pro Gly Pro Lys Thr Pro Pro Arg Thr Met Gln Glu 
                165                 170                 175     


Ser Pro Leu Gly Leu Gln Val Lys Glu Glu Ser Glu Val Thr Glu Asp 
            180                 185                 190         


Ser Asp Phe Leu Glu Ser Gly Pro Leu Ala Ala Thr Gln Glu Ser Val 
        195                 200                 205             


Pro Thr Leu Leu Pro Glu Glu Ala Gln Arg Cys Gly Thr Val Leu Asp 
    210                 215                 220                 


Gln Ile Phe Pro His Ser Lys Thr Gly Pro Glu Gly Pro Ser Trp Arg 
225                 230                 235                 240 


Glu His Pro Arg Ala Leu Trp His Glu Glu Ala Gly Gly Ile Phe Ser 
                245                 250                 255     


Pro Gly Phe Ala Leu Gln Leu Gly Ser Ile Ser Ala Gly Pro Gly Ser 
            260                 265                 270         


Val Ser Pro His Leu His Val Pro Trp Asp Leu Gly Met Ala Gly Leu 
        275                 280                 285             


Ser Gly Gln Ile Gln Ser Pro Ser Arg Glu Gly Gly Phe Ala His Ala 
    290                 295                 300                 


Leu Leu Leu Pro Ser Asp Leu Arg Ser Glu Gln Asp Pro Thr Asp Glu 
305                 310                 315                 320 


Asp Pro Cys Arg Gly Val Gly Pro Ala Leu Ile Thr Thr Arg Trp Arg 
                325                 330                 335     


Ser Pro Arg Gly Arg Ser Arg Gly Arg Pro Ser Thr Gly Gly Gly Val 
            340                 345                 350         


Val Arg Gly Gly Arg Cys Asp Val Cys Gly Lys Val Phe Ser Gln Arg 
        355                 360                 365             


Ser Asn Leu Leu Arg His Gln Lys Ile His Thr Gly Glu Arg Pro Phe 
    370                 375                 380                 


Val Cys Ser Glu Cys Gly Arg Ser Phe Ser Arg Ser Ser His Leu Leu 
385                 390                 395                 400 


Arg His Gln Leu Thr His Thr Glu Glu Arg Pro Phe Val Cys Gly Asp 
                405                 410                 415     


Cys Gly Gln Gly Phe Val Arg Ser Ala Arg Leu Glu Glu His Arg Arg 
            420                 425                 430         


Val His Thr Gly Glu Gln Pro Phe Arg Cys Ala Glu Cys Gly Gln Ser 
        435                 440                 445             


Phe Arg Gln Arg Ser Asn Leu Leu Gln His Gln Arg Ile His Gly Asp 
    450                 455                 460                 


Pro Pro Gly Pro Gly Ala Lys Pro Pro Ala Pro Pro Gly Ala Pro Glu 
465                 470                 475                 480 


Pro Pro Gly Pro Phe Pro Cys Ser Glu Cys Arg Glu Ser Phe Ala Arg 
                485                 490                 495     


Arg Ala Val Leu Leu Glu His Gln Ala Val His Thr Gly Asp Lys Ser 
            500                 505                 510         


Phe Gly Cys Val Glu Cys Gly Glu Arg Phe Gly Arg Arg Ser Val Leu 
        515                 520                 525             


Leu Gln His Arg Arg Val His Ser Gly Glu Arg Pro Phe Ala Cys Ala 
    530                 535                 540                 


Glu Cys Gly Gln Ser Phe Arg Gln Arg Ser Asn Leu Thr Gln His Arg 
545                 550                 555                 560 


Arg Ile His Thr Gly Glu Arg Pro Phe Ala Cys Ala Glu Cys Gly Lys 
                565                 570                 575     


Ala Phe Arg Gln Arg Pro Thr Leu Thr Gln His Leu Arg Val His Thr 
            580                 585                 590         


Gly Glu Lys Pro Phe Ala Cys Pro Glu Cys Gly Gln Arg Phe Ser Gln 
        595                 600                 605             


Arg Leu Lys Leu Thr Arg His Gln Arg Thr His Thr Gly Glu Lys Pro 
    610                 615                 620                 


Tyr His Cys Gly Glu Cys Gly Leu Gly Phe Thr Gln Val Ser Arg Leu 
625                 630                 635                 640 


Thr Glu His Gln Arg Ile His Thr Gly Glu Arg Pro Phe Ala Cys Pro 
                645                 650                 655     


Glu Cys Gly Gln Ser Phe Arg Gln His Ala Asn Leu Thr Gln His Arg 
            660                 665                 670         


Arg Ile His Thr Gly Glu Arg Pro Tyr Ala Cys Pro Glu Cys Gly Lys 
        675                 680                 685             


Ala Phe Arg Gln Arg Pro Thr Leu Thr Gln His Leu Arg Thr His Arg 
    690                 695                 700                 


Arg Glu Lys Pro Phe Ala Cys Gln Asp Cys Gly Arg Arg Phe His Gln 
705                 710                 715                 720 


Ser Thr Lys Leu Ile Gln His Gln Arg Val His Ser Ala Glu 
                725                 730                 


<210>  51
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Arg Tyr Ala Gly Ala Leu Glu Glu Val Ala Asp Gly Ala Arg 
1               5                   10                  15      


Gln Gln Glu Arg His Tyr Gln Leu Leu Ser Ala Leu Gln Ser Leu Val 
            20                  25                  30          


Lys Glu Leu Pro Ser Ser Phe Gln Gln Arg Leu Ser Tyr Thr Thr Leu 
        35                  40                  45              


Ser Asp Leu Ala Leu Ala Leu Leu Asp Gly Thr Val Phe Glu Ile Val 
    50                  55                  60                  


Gln Gly Leu Leu Glu Ile Gln His Leu Thr Glu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Gln Arg Leu Arg Leu Gln Asn Glu His Arg Val Leu Arg Gln Ala Leu 
                85                  90                  95      


Arg Gln Lys His Gln Glu Ala Gln Gln Ala Cys Arg Pro His Asn Leu 
            100                 105                 110         


Pro Val Leu Gln Ala Ala Gln Gln Arg Glu Leu Glu Ala Val Glu His 
        115                 120                 125             


Arg Ile Arg Glu Glu Gln Arg Ala Met Asp Gln Lys Ile Val Leu Glu 
    130                 135                 140                 


Leu Asp Arg Lys Val Ala Asp Gln Gln Ser Thr Leu Glu Lys Ala Gly 
145                 150                 155                 160 


Val Ala Gly Phe Tyr Val Thr Thr Asn Pro Gln Glu Leu Met Leu Gln 
                165                 170                 175     


Met Asn Leu Leu Glu Leu Ile Arg Lys Leu Gln Gln Arg Gly Cys Trp 
            180                 185                 190         


Ala Gly Lys Ala Ala Leu Gly Leu Gly Gly Pro Trp Gln Leu Pro Ala 
        195                 200                 205             


Ala Gln Cys Asp Gln Lys Gly Ser Pro Val Pro Pro 
    210                 215                 220 


<210>  52
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  53
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Val Cys Pro Asn Gly Tyr Asp Pro Gly Gly Arg His Leu Leu Leu 
1               5                   10                  15      


Phe Ile Ile Ile Leu Ala Ala Trp Glu Ala Gly Arg Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Asn Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Ala Val Cys Lys Phe Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Glu Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Arg Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Pro Glu Asp Ala Gln Pro Gly Thr Val 
        355                 360                 365             


Ile Thr Leu Ile Ser Val Phe Asp Arg Asp Phe Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro Arg Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gly 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Leu Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Arg Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Val Ala Ala Gly Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Leu Gly Ile Ala Gly 
        675                 680                 685             


Pro Glu Thr Glu Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Ser Ser Glu Gly Ala Cys Ser Leu Val Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Phe Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Ser Ser Thr Asp 
    770                 775                 780                 


Asn Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg 
785                 790                 795                 800 


Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg 
                805                 810                 815     


Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala 
            820                 825                 830         


Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly 
        835                 840                 845             


Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys 
    850                 855                 860                 


Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser 
865                 870                 875                 880 


Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp 
                885                 890                 895     


Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys 
            900                 905                 910         


Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly 
        915                 920                 925             


Asn Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935         


<210>  54
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  55
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  56
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ala Leu Met Arg Ser Lys Asp Ser Ser Cys Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Val Leu Met Val Glu Ser Ser Gln Ile Gly Ser Ser Arg 
            20                  25                  30          


Ala Lys Leu Asn Ser Ile Lys Ser Ser Leu Gly Gly Glu Thr Pro Gly 
        35                  40                  45              


Gln Ala Ala Asn Arg Ser Ala Gly Met Tyr Gln Gly Leu Ala Phe Gly 
    50                  55                  60                  


Gly Ser Lys Lys Gly Lys Asn Leu Gly Gln Ala Tyr Pro Cys Ser Ser 
65                  70                  75                  80  


Asp Lys Glu Cys Glu Val Gly Arg Tyr Cys His Ser Pro His Gln Gly 
                85                  90                  95      


Ser Ser Ala Cys Met Val Cys Arg Arg Lys Lys Lys Arg Cys His Arg 
            100                 105                 110         


Asp Gly Met Cys Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile 
        115                 120                 125             


Pro Val Thr Glu Ser Ile Leu Thr Pro His Ile Pro Ala Leu Asp Gly 
    130                 135                 140                 


Thr Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu 
145                 150                 155                 160 


Gly Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys 
                165                 170                 175     


Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly 
            180                 185                 190         


Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu 
        195                 200                 205             


His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly 
    210                 215                 220                 


Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys 
225                 230                 235                 240 


Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys 
                245                 250                 255     


Gln Lys Ile 
            


<210>  57
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  58
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  59
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile Pro 
        515                 520                 525             


Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser Leu 
    530                 535                 540                 


Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Thr 
545                 550                 555                 560 


Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile Met 
                565                 570                 575     


Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro 
            580                 585                 590         


Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala 
        595                 600                 605             


Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr Val 
    610                 615                 620                 


Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg 
625                 630                 635                 640 


Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Thr 
                645                 650                 655     


Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu Glu 
            660                 665                 670         


Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly 
        675                 680                 685             


Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr 
    690                 695                 700                 


Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr Phe 
705                 710                 715                 720 


Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr Ile 
                725                 730                 735     


Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr Tyr 
            740                 745                 750         


Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val 
        755                 760                 765             


Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Thr 
    770                 775                 780                 


Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu 
785                 790                 795                 800 


Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser Gly 
                805                 810                 815     


Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro Pro 
            820                 825                 830         


Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val Ala 
        835                 840                 845             


Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser 
    850                 855                 860                 


Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg Ala 
865                 870                 875                 880 


Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser Ala 
                885                 890                 895     


Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu Pro 
            900                 905                 910         


Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg 
        915                 920                 925             


Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala 
    930                 935                 940                 


Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu 
945                 950                 955                 960 


Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu Gly 
                965                 970                 975     


Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys Ser 
            980                 985                 990         


Ser Pro Asp Glu Gly Ser Phe Leu  Tyr Thr Leu Pro Asp  Asp Ser Thr 
        995                 1000                 1005             


His Gln  Leu Leu Gln Pro His  His Asp Cys Cys Gln  Arg Gln Glu 
    1010                 1015                 1020             


Gln Pro  Ala Ala Val Gly Gln  Ser Gly Val Arg Arg  Ala Pro Asp 
    1025                 1030                 1035             


Ser Pro  Val Leu Glu Ala Val  Trp Asp Pro Pro Phe  His Ser Gly 
    1040                 1045                 1050             


Pro Pro  Cys Cys Leu Gly Leu  Val Pro Val Glu Glu  Val Asp Ser 
    1055                 1060                 1065             


Pro Asp  Ser Cys Gln Val Ser  Gly Gly Asp Trp Cys  Pro Gln His 
    1070                 1075                 1080             


Pro Val  Gly Ala Tyr Val Gly  Gln Glu Pro Gly Met  Gln Leu Ser 
    1085                 1090                 1095             


Pro Gly  Pro Leu Val Arg Val  Ser Phe Glu Thr Pro  Pro Leu Thr 
    1100                 1105                 1110             


Ile 
    


<210>  60
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Ala Ser Ile Ser Gly Tyr Thr Phe Ser Ala Val Cys Phe His 
1               5                   10                  15      


Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe Leu Leu Gly Glu Val 
            20                  25                  30          


Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser Gln Ile Ser Asn Thr 
        35                  40                  45              


Glu Phe Leu Gln Val Ile Glu Ile His Asn His Gln Pro Cys Ser Lys 
    50                  55                  60                  


Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val Asn Glu Glu Ser Leu 
65                  70                  75                  80  


Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val Ile Gly Trp Tyr Arg 
                85                  90                  95      


Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr Arg Glu Gln Val Leu 
            100                 105                 110         


His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro Asp Leu Val Phe Leu 
        115                 120                 125             


Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser Thr His Ala Leu Glu 
    130                 135                 140                 


Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn Gln Arg Ile Ser Leu 
145                 150                 155                 160 


Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln Glu Tyr Lys Val Ser 
                165                 170                 175     


Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys Val Ile Lys Glu His 
            180                 185                 190         


Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met Lys Asp Ile Arg Ala 
        195                 200                 205             


Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys Val Gln Ala Val Cys 
    210                 215                 220                 


Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu Ser Cys Gln Ala Glu 
225                 230                 235                 240 


Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg Lys Asn Glu Lys Glu 
                245                 250                 255     


Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser Arg Gln Met Pro Ser 
            260                 265                 270         


Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met Pro Ser Ser Gly Phe 
        275                 280                 285             


Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala Glu Ala Ser Asp Pro 
    290                 295                 300                 


Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn Gln Glu Ser Thr Leu 
305                 310                 315                 320 


Ser His Ser Arg Met Glu Arg Ser Val Phe Met Pro Arg Pro Gln Ala 
                325                 330                 335     


Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala Gly Leu Lys Tyr Pro 
            340                 345                 350         


Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg Ala Ala Gly Asp Ser 
        355                 360                 365             


Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn Leu Ile Asp Pro Thr 
    370                 375                 380                 


Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys Asp Ser Arg Pro Met 
385                 390                 395                 400 


Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln Thr Ser Gln Ile 
                405                 410                 415 


<210>  61
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  61

Met His Pro Ala Val Phe Leu Ser Leu Pro Asp Leu Arg Cys Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Thr Trp Val Phe Thr Pro Val Thr Thr Glu Ile Thr 
            20                  25                  30          


Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val 
        35                  40                  45              


Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu 
    50                  55                  60                  


His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Phe Pro 
65                  70                  75                  80  


Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser 
                85                  90                  95      


Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu 
            100                 105                 110         


Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser 
        115                 120                 125             


Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asp Pro Ile 
    130                 135                 140                 


Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp Arg Ser Lys 
145                 150                 155                 160 


Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp Asn Tyr Arg 
                165                 170                 175     


Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys Ala Phe Leu 
            180                 185                 190         


Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser Gly Asp Asn 
        195                 200                 205             


Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met Val Tyr Leu 
    210                 215                 220                 


Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys 
225                 230                 235                 240 


Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu 
                245                 250                 255     


Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu Asp 
            260                 265                 270         


Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile 
        275                 280                 285             


Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe 
    290                 295                 300                 


Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val 
305                 310                 315                 320 


Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys 
                325                 330                 335     


Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His 
            340                 345                 350         


Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp 
        355                 360                 365             


Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro Glu 
    370                 375                 380                 


Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu 
385                 390                 395                 400 


Arg Asp Arg Asp Glu Leu 
                405     


<210>  62
<211>  913
<212>  PRT
<213>  Staphylococcus aureus

<400>  62

Met Lys Lys Arg Ile Asp Tyr Leu Ser Asn Lys Gln Asn Lys Tyr Ser 
1               5                   10                  15      


Ile Arg Arg Phe Thr Val Gly Thr Thr Ser Val Ile Val Gly Ala Thr 
            20                  25                  30          


Ile Leu Phe Gly Ile Gly Asn His Gln Ala Gln Ala Ser Glu Gln Ser 
        35                  40                  45              


Asn Asp Thr Thr Gln Ser Ser Lys Asn Asn Ala Ser Ala Asp Ser Glu 
    50                  55                  60                  


Lys Asn Asn Met Ile Glu Thr Pro Gln Leu Asn Thr Thr Ala Asn Asp 
65                  70                  75                  80  


Thr Ser Asp Ile Ser Ala Asn Thr Asn Ser Ala Asn Val Asp Ser Thr 
                85                  90                  95      


Thr Lys Pro Met Ser Thr Gln Thr Ser Asn Thr Thr Thr Thr Glu Pro 
            100                 105                 110         


Ala Ser Thr Asn Glu Thr Pro Gln Pro Thr Ala Ile Lys Asn Gln Ala 
        115                 120                 125             


Thr Ala Ala Lys Met Gln Asp Gln Thr Val Pro Gln Glu Ala Asn Ser 
    130                 135                 140                 


Gln Val Asp Asn Lys Thr Thr Asn Asp Ala Asn Ser Ile Ala Thr Asn 
145                 150                 155                 160 


Ser Glu Leu Lys Asn Ser Gln Thr Leu Asp Leu Pro Gln Ser Ser Pro 
                165                 170                 175     


Gln Thr Ile Ser Asn Ala Gln Gly Thr Ser Lys Pro Ser Val Arg Thr 
            180                 185                 190         


Arg Ala Val Arg Ser Leu Ala Val Ala Glu Pro Val Val Asn Ala Ala 
        195                 200                 205             


Asp Ala Lys Gly Thr Asn Val Asn Asp Lys Val Thr Ala Ser Asn Phe 
    210                 215                 220                 


Lys Leu Glu Lys Thr Thr Phe Asp Pro Asn Gln Ser Gly Asn Thr Phe 
225                 230                 235                 240 


Met Ala Ala Asn Phe Thr Val Thr Asp Lys Val Lys Ser Gly Asp Tyr 
                245                 250                 255     


Phe Thr Ala Lys Leu Pro Asp Ser Leu Thr Gly Asn Gly Asp Val Asp 
            260                 265                 270         


Tyr Ser Asn Ser Asn Asn Thr Met Pro Ile Ala Asp Ile Lys Ser Thr 
        275                 280                 285             


Asn Gly Asp Val Val Ala Lys Ala Thr Tyr Asp Ile Leu Thr Lys Thr 
    290                 295                 300                 


Tyr Thr Phe Val Phe Thr Asp Tyr Val Asn Asn Lys Glu Asn Ile Asn 
305                 310                 315                 320 


Gly Gln Phe Ser Leu Pro Leu Phe Thr Asp Arg Ala Lys Ala Pro Lys 
                325                 330                 335     


Ser Gly Thr Tyr Asp Ala Asn Ile Asn Ile Ala Asp Glu Met Phe Asn 
            340                 345                 350         


Asn Lys Ile Thr Tyr Asn Tyr Ser Ser Pro Ile Ala Gly Ile Asp Lys 
        355                 360                 365             


Pro Asn Gly Ala Asn Ile Ser Ser Gln Ile Ile Gly Val Asp Thr Ala 
    370                 375                 380                 


Ser Gly Gln Asn Thr Tyr Lys Gln Thr Val Phe Val Asn Pro Lys Gln 
385                 390                 395                 400 


Arg Val Leu Gly Asn Thr Trp Val Tyr Ile Lys Gly Tyr Gln Asp Lys 
                405                 410                 415     


Ile Glu Glu Ser Ser Gly Lys Val Ser Ala Thr Asp Thr Lys Leu Arg 
            420                 425                 430         


Ile Phe Glu Val Asn Asp Thr Ser Lys Leu Ser Asp Ser Tyr Tyr Ala 
        435                 440                 445             


Asp Pro Asn Asp Ser Asn Leu Lys Glu Val Thr Asp Gln Phe Lys Asn 
    450                 455                 460                 


Arg Ile Tyr Tyr Glu His Pro Asn Val Ala Ser Ile Lys Phe Gly Asp 
465                 470                 475                 480 


Ile Thr Lys Thr Tyr Val Val Leu Val Glu Gly His Tyr Asp Asn Thr 
                485                 490                 495     


Gly Lys Asn Leu Lys Thr Gln Val Ile Gln Glu Asn Val Asp Pro Val 
            500                 505                 510         


Thr Asn Arg Asp Tyr Ser Ile Phe Gly Trp Asn Asn Glu Asn Val Val 
        515                 520                 525             


Arg Tyr Gly Gly Gly Ser Ala Asp Gly Asp Ser Ala Val Asn Pro Lys 
    530                 535                 540                 


Asp Pro Thr Pro Gly Pro Pro Val Asp Pro Glu Pro Ser Pro Asp Pro 
545                 550                 555                 560 


Glu Pro Glu Pro Thr Pro Asp Pro Glu Pro Ser Pro Asp Pro Glu Pro 
                565                 570                 575     


Glu Pro Ser Pro Asp Pro Asp Pro Asp Ser Asp Ser Asp Ser Asp Ser 
            580                 585                 590         


Gly Ser Asp Ser Asp Ser Gly Ser Asp Ser Asp Ser Glu Ser Asp Ser 
        595                 600                 605             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Glu Ser 
    610                 615                 620                 


Asp Ser Asp Ser Glu Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
625                 630                 635                 640 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                645                 650                 655     


Asp Ser Asp Ser Asp Ser Asp Ser Glu Ser Asp Ser Asp Ser Glu Ser 
            660                 665                 670         


Asp Ser Glu Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        675                 680                 685             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    690                 695                 700                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
705                 710                 715                 720 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                725                 730                 735     


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
            740                 745                 750         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        755                 760                 765             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    770                 775                 780                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                805                 810                 815     


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
            820                 825                 830         


Asp Ser Asp Ser Asp Ser Asp Ser Arg Val Thr Pro Pro Asn Asn Glu 
        835                 840                 845             


Gln Lys Ala Pro Ser Asn Pro Lys Gly Glu Val Asn His Ser Asn Lys 
    850                 855                 860                 


Val Ser Lys Gln His Lys Thr Asp Ala Leu Pro Glu Thr Gly Asp Lys 
865                 870                 875                 880 


Ser Glu Asn Thr Asn Ala Thr Leu Phe Gly Ala Met Met Ala Leu Leu 
                885                 890                 895     


Gly Ser Leu Leu Leu Phe Arg Lys Arg Lys Gln Asp His Lys Glu Lys 
            900                 905                 910         


Ala 
    


<210>  63
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  63

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  64
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Arg Ser Leu Cys Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Leu Thr Pro Arg Ala Gly Asp Ala Ala Val Ile Thr Gly 
            20                  25                  30          


Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys Cys Ala Val 
        35                  40                  45              


Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro Met Gly Lys Leu 
    50                  55                  60                  


Gly Asp Ser Cys His Pro Leu Thr Arg Lys Asn Asn Phe Gly Asn Gly 
65                  70                  75                  80  


Arg Gln Glu Arg Arg Lys Arg Lys Arg Ser Lys Arg Lys Lys Glu Val 
                85                  90                  95      


Pro Phe Phe Gly Arg Arg Met His His Thr Cys Pro Cys Leu Pro Gly 
            100                 105                 110         


Leu Ala Cys Leu Arg Thr Ser Phe Asn Arg Phe Ile Cys Leu Ala Gln 
        115                 120                 125             


Lys 
    


<210>  65
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gly Lys Arg Gln His Gln Lys Asp Lys Met Tyr Ile Thr Cys Ala 
1               5                   10                  15      


Glu Tyr Thr His Phe Tyr Gly Gly Lys Lys Pro Asp Leu Pro Gln Thr 
            20                  25                  30          


Asn Phe Arg Arg Leu Pro Phe Asp His Cys Ser Leu Ser Leu Gln Pro 
        35                  40                  45              


Phe Val Tyr Pro Val Cys Thr Pro Asp Gly Ile Val Phe Asp Leu Leu 
    50                  55                  60                  


Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser Asn Gly 
65                  70                  75                  80  


Glu Lys Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser Lys Asn 
                85                  90                  95      


Ser Glu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val Phe Thr Asn 
            100                 105                 110         


Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val Tyr Ala Tyr 
        115                 120                 125             


Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe Arg Asp Leu 
    130                 135                 140                 


Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr Leu Gln Asp 
145                 150                 155                 160 


Pro Thr Asn Leu Asp Lys Phe Asn Val Ser Asn Phe Tyr His Val Lys 
                165                 170                 175     


Asn Asn Met Lys Ile Ile Asp Pro Asp Glu Glu Lys Ala Lys Gln Asp 
            180                 185                 190         


Pro Ser Tyr Tyr Leu Lys Asn Thr Asn Ala Glu Thr Arg Glu Thr Leu 
        195                 200                 205             


Gln Glu Leu Tyr Lys Glu Phe Lys Gly Asp Glu Ile Leu Ala Ala Thr 
    210                 215                 220                 


Met Lys Ala Pro Glu Lys Lys Lys Val Asp Lys Leu Asn Ala Ala His 
225                 230                 235                 240 


Tyr Ser Thr Gly Lys Val Ser Ala Ser Phe Thr Ser Thr Ala Met Val 
                245                 250                 255     


Pro Glu Thr Thr His Glu Ala Ala Ala Ile Asp Glu Asp Val Leu Arg 
            260                 265                 270         


Tyr Gln Phe Val Lys Lys Lys Gly Tyr Val Arg Leu His Thr Asn Lys 
        275                 280                 285             


Gly Asp Leu Asn Leu Glu Leu His Cys Asp Leu Thr Pro Lys Thr Cys 
    290                 295                 300                 


Glu Asn Phe Ile Arg Leu Cys Lys Lys His Tyr Tyr Asp Gly Thr Ile 
305                 310                 315                 320 


Phe His Arg Ser Ile Arg Asn Phe Val Ile Gln Gly Gly Asp Pro Thr 
                325                 330                 335     


Gly Thr Gly Thr Gly Gly Glu Ser Tyr Trp Gly Lys Pro Phe Lys Asp 
            340                 345                 350         


Glu Phe Arg Pro Asn Leu Ser His Thr Gly Arg Gly Ile Leu Ser Met 
        355                 360                 365             


Ala Asn Ser Gly Pro Asn Ser Asn Arg Ser Gln Phe Phe Ile Thr Phe 
    370                 375                 380                 


Arg Ser Cys Ala Tyr Leu Asp Lys Lys His Thr Ile Phe Gly Arg Val 
385                 390                 395                 400 


Val Gly Gly Phe Asp Val Leu Thr Ala Met Glu Asn Val Glu Ser Asp 
                405                 410                 415     


Pro Lys Thr Asp Arg Pro Lys Glu Glu Ile Arg Ile Asp Ala Thr Thr 
            420                 425                 430         


Val Phe Val Asp Pro Tyr Glu Glu Ala Asp Ala Gln Ile Ala Gln Glu 
        435                 440                 445             


Arg Lys Thr Gln Leu Lys Val Ala Pro Glu Thr Lys Val Lys Ser Ser 
    450                 455                 460                 


Gln Pro Gln Ala Gly Ser Gln Gly Pro Gln Thr Phe Arg Gln Gly Val 
465                 470                 475                 480 


Gly Lys Tyr Ile Asn Pro Ala Ala Thr Lys Arg Ala Ala Glu Glu Glu 
                485                 490                 495     


Pro Ser Thr Ser Ala Thr Val Pro Met Ser Lys Lys Lys Pro Ser Arg 
            500                 505                 510         


Gly Phe Gly Asp Phe Ser Ser Trp 
        515                 520 


<210>  66
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 
65                  70                  75                  80  


Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 
                85                  90                  95      


Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
            100                 105                 110         


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
        115                 120                 125             


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
    130                 135                 140                 


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
145                 150                 155                 160 


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
                165                 170                 175     


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
            180                 185                 190         


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
        195                 200                 205             


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
    210                 215                 220                 


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
225                 230                 235                 240 


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
                245                 250                 255     


Glu Arg Cys Val Glu Ile Pro 
            260             


<210>  67
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Ser Ser Asn Gly 
1               5                   10                  15      


Pro Val Lys Lys Ser Met Arg Glu Lys Ala Val Glu Arg Arg Ser Val 
            20                  25                  30          


Asn Lys Glu His Asn Ser Asn Phe Lys Ala Gly Tyr Ile Pro Ile Asp 
        35                  40                  45              


Glu Asp Arg Leu His Lys Thr Gly Leu Arg Gly Arg Lys Gly Asn Leu 
    50                  55                  60                  


Ala Ile Cys Val Ile Ile Leu Leu Phe Ile Leu Ala Val Ile Asn Leu 
65                  70                  75                  80  


Ile Ile Thr Leu Val Ile Trp Ala Val Ile Arg Ile Gly Pro Asn Gly 
                85                  90                  95      


Cys Asp Ser Met Glu Phe His Glu Ser Gly Leu Leu Arg Phe Lys Gln 
            100                 105                 110         


Val Ser Asp Met Gly Val Ile His Pro Leu Tyr Lys Ser Thr Val Gly 
        115                 120                 125             


Gly Arg Arg Asn Glu Asn Leu Val Ile Thr Gly Asn Asn Gln Pro Ile 
    130                 135                 140                 


Val Phe Gln Gln Gly Thr Thr Lys Leu Ser Val Glu Asn Asn Lys Thr 
145                 150                 155                 160 


Ser Ile Thr Ser Asp Ile Gly Met Gln Phe Phe Asp Pro Arg Thr Gln 
                165                 170                 175     


Asn Ile Leu Phe Ser Thr Asp Tyr Glu Thr His Glu Phe His Leu Pro 
            180                 185                 190         


Ser Gly Val Lys Ser Leu Asn Val Gln Lys Ala Ser Thr Glu Arg Ile 
        195                 200                 205             


Thr Ser Asn Ala Thr Ser Asp Leu Asn Ile Lys Val Asp Gly Arg Ala 
    210                 215                 220                 


Ile Val Arg Gly Asn Glu Gly Val Phe Ile Met Gly Lys Thr Ile Glu 
225                 230                 235                 240 


Phe His Met Gly Gly Asn Met Glu Leu Lys Ala Glu Asn Ser Ile Ile 
                245                 250                 255     


Leu Asn Gly Ser Val Met Val Ser Thr Thr Arg Leu Pro Ser Ser Ser 
            260                 265                 270         


Ser Gly Asp Gln Leu Gly Ser Gly Asp Trp Val Arg Tyr Lys Leu Cys 
        275                 280                 285             


Met Cys Ala Asp Gly Thr Leu Phe Lys Val Gln Val Thr Ser Gln Asn 
    290                 295                 300                 


Met Gly Cys Gln Ile Ser Asp Asn Pro Cys Gly Asn Thr His 
305                 310                 315             


<210>  68
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  69
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Asn Asn Leu Leu Cys Cys Ala Leu Val Phe Leu Asp Ile Ser Ile 
1               5                   10                  15      


Lys Trp Thr Thr Gln Glu Thr Phe Pro Pro Lys Tyr Leu His Tyr Asp 
            20                  25                  30          


Glu Glu Thr Ser His Gln Leu Leu Cys Asp Lys Cys Pro Pro Gly Thr 
        35                  40                  45              


Tyr Leu Lys Gln His Cys Thr Ala Lys Trp Lys Thr Val Cys Ala Pro 
    50                  55                  60                  


Cys Pro Asp His Tyr Tyr Thr Asp Ser Trp His Thr Ser Asp Glu Cys 
65                  70                  75                  80  


Leu Tyr Cys Ser Pro Val Cys Lys Glu Leu Gln Tyr Val Lys Gln Glu 
                85                  90                  95      


Cys Asn Arg Thr His Asn Arg Val Cys Glu Cys Lys Glu Gly Arg Tyr 
            100                 105                 110         


Leu Glu Ile Glu Phe Cys Leu Lys His Arg Ser Cys Pro Pro Gly Phe 
        115                 120                 125             


Gly Val Val Gln Ala Gly Thr Pro Glu Arg Asn Thr Val Cys Lys Arg 
    130                 135                 140                 


Cys Pro Asp Gly Phe Phe Ser Asn Glu Thr Ser Ser Lys Ala Pro Cys 
145                 150                 155                 160 


Arg Lys His Thr Asn Cys Ser Val Phe Gly Leu Leu Leu Thr Gln Lys 
                165                 170                 175     


Gly Asn Ala Thr His Asp Asn Ile Cys Ser Gly Asn Ser Glu Ser Thr 
            180                 185                 190         


Gln Lys Cys Gly Ile Asp Val Thr Leu Cys Glu Glu Ala Phe Phe Arg 
        195                 200                 205             


Phe Ala Val Pro Thr Lys Phe Thr Pro Asn Trp Leu Ser Val Leu Val 
    210                 215                 220                 


Asp Asn Leu Pro Gly Thr Lys Val Asn Ala Glu Ser Val Glu Arg Ile 
225                 230                 235                 240 


Lys Arg Gln His Ser Ser Gln Glu Gln Thr Phe Gln Leu Leu Lys Leu 
                245                 250                 255     


Trp Lys His Gln Asn Lys Asp Gln Asp Ile Val Lys Lys Ile Ile Gln 
            260                 265                 270         


Asp Ile Asp Leu Cys Glu Asn Ser Val Gln Arg His Ile Gly His Ala 
        275                 280                 285             


Asn Leu Thr Phe Glu Gln Leu Arg Ser Leu Met Glu Ser Leu Pro Gly 
    290                 295                 300                 


Lys Lys Val Gly Ala Glu Asp Ile Glu Lys Thr Ile Lys Ala Cys Lys 
305                 310                 315                 320 


Pro Ser Asp Gln Ile Leu Lys Leu Leu Ser Leu Trp Arg Ile Lys Asn 
                325                 330                 335     


Gly Asp Gln Asp Thr Leu Lys Gly Leu Met His Ala Leu Lys His Ser 
            340                 345                 350         


Lys Thr Tyr His Phe Pro Lys Thr Val Thr Gln Ser Leu Lys Lys Thr 
        355                 360                 365             


Ile Arg Phe Leu His Ser Phe Thr Met Tyr Lys Leu Tyr Gln Lys Leu 
    370                 375                 380                 


Phe Leu Glu Met Ile Gly Asn Gln Val Gln Ser Val Lys Ile Ser Cys 
385                 390                 395                 400 


Leu 
    


<210>  70
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Lys Ala Leu Leu Ala Leu Pro Leu Leu Leu Leu Leu Ser Thr Pro 
1               5                   10                  15      


Pro Cys Ala Pro Gln Val Ser Gly Ile Arg Gly Asp Ala Leu Glu Arg 
            20                  25                  30          


Phe Cys Leu Gln Gln Pro Leu Asp Cys Asp Asp Ile Tyr Ala Gln Gly 
        35                  40                  45              


Tyr Gln Ser Asp Gly Val Tyr Leu Ile Tyr Pro Ser Gly Pro Ser Val 
    50                  55                  60                  


Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp Thr 
65                  70                  75                  80  


Val Phe Gln Lys Arg Phe Asn Gly Ser Val Ser Phe Phe Arg Gly Trp 
                85                  90                  95      


Asn Asp Tyr Lys Leu Gly Phe Gly Arg Ala Asp Gly Glu Tyr Trp Leu 
            100                 105                 110         


Gly Leu Gln Asn Met His Leu Leu Thr Leu Lys Gln Lys Tyr Glu Leu 
        115                 120                 125             


Arg Val Asp Leu Glu Asp Phe Glu Asn Asn Thr Ala Tyr Ala Lys Tyr 
    130                 135                 140                 


Ala Asp Phe Ser Ile Ser Pro Asn Ala Val Ser Ala Glu Glu Asp Gly 
145                 150                 155                 160 


Tyr Thr Leu Phe Val Ala Gly Phe Glu Asp Gly Gly Ala Gly Asp Ser 
                165                 170                 175     


Leu Ser Tyr His Ser Gly Gln Lys Phe Ser Thr Phe Asp Arg Asp Gln 
            180                 185                 190         


Asp Leu Phe Val Gln Asn Cys Ala Ala Leu Ser Ser Gly Ala Phe Trp 
        195                 200                 205             


Phe Arg Ser Cys His Phe Ala Asn Leu Asn Gly Phe Tyr Leu Gly Gly 
    210                 215                 220                 


Ser His Leu Ser Tyr Ala Asn Gly Ile Asn Trp Ala Gln Trp Lys Gly 
225                 230                 235                 240 


Phe Tyr Tyr Ser Leu Lys Arg Thr Glu Met Lys Ile Arg Arg Ala 
                245                 250                 255 


<210>  71
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Glu Leu Ser Val Ala Gln Cys Thr Gln Arg Pro Val 
            820                 825                 830         


Asp Ile Val Phe Leu Leu Asp Gly Ser Glu Arg Leu Gly Glu Gln Asn 
        835                 840                 845             


Phe His Lys Ala Arg Arg Phe Val Glu Gln Val Ala Arg Arg Leu Thr 
    850                 855                 860                 


Leu Ala Arg Arg Asp Asp Asp Pro Leu Asn Ala Arg Val Ala Leu Leu 
865                 870                 875                 880 


Gln Phe Gly Gly Pro Gly Glu Gln Gln Val Ala Phe Pro Leu Ser His 
                885                 890                 895     


Asn Leu Thr Ala Ile His Glu Ala Leu Glu Thr Thr Gln Tyr Leu Asn 
            900                 905                 910         


Ser Phe Ser His Val Gly Ala Gly Val Val His Ala Ile Asn Ala Ile 
        915                 920                 925             


Val Arg Ser Pro Arg Gly Gly Ala Arg Arg His Ala Glu Leu Ser Phe 
    930                 935                 940                 


Val Phe Leu Thr Asp Gly Val Thr Gly Asn Asp Ser Leu His Glu Ser 
945                 950                 955                 960 


Ala His Ser Met Arg Lys Gln Asn Val Val Pro Thr Val Leu Ala Leu 
                965                 970                 975     


Gly Ser Asp Val Asp Met Asp Val Leu Thr Thr Leu Ser Leu Gly Asp 
            980                 985                 990         


Arg Ala Ala Val Phe His Glu Lys  Asp Tyr Asp Ser Leu  Ala Gln Pro 
        995                 1000                 1005             


Gly Phe  Phe Asp Arg Phe Ile  Arg Trp Ile Cys 
    1010                 1015                 


<210>  72
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ala Gly Gly Thr Gly Gly Leu Arg Glu Glu Gln Arg Tyr Gly 
1               5                   10                  15      


Leu Ser Cys Gly Arg Leu Gly Gln Asp Asn Ile Thr Val Leu His Val 
            20                  25                  30          


Lys Leu Thr Glu Thr Ala Ile Arg Ala Leu Glu Thr Tyr Gln Ser His 
        35                  40                  45              


Lys Asn Leu Ile Pro Phe Arg Pro Ser Ile Gln Phe Gln Gly Leu His 
    50                  55                  60                  


Gly Leu Val Lys Ile Pro Lys Asn Asp Pro Leu Asn Glu Val His Asn 
65                  70                  75                  80  


Phe Asn Phe Tyr Leu Ser Asn Val Gly Lys Asp Asn Pro Gln Gly Ser 
                85                  90                  95      


Phe Asp Cys Ile Gln Gln Thr Phe Ser Ser Ser Gly Ala Ser Gln Leu 
            100                 105                 110         


Asn Cys Leu Gly Phe Ile Gln Asp Lys Ile Thr Val Cys Ala Thr Asn 
        115                 120                 125             


Asp Ser Tyr Gln Met Thr Arg Glu Arg Met Thr Gln Ala Glu Glu Glu 
    130                 135                 140                 


Ser Arg Asn Arg Ser Thr Lys Val Ile Lys Pro Gly Gly Pro Tyr Val 
145                 150                 155                 160 


Gly Lys Arg Val Gln Ile Arg Lys Ala Pro Gln Ala Val Ser Asp Thr 
                165                 170                 175     


Val Pro Glu Arg Lys Arg Ser Thr Pro Met Asn Pro Ala Asn Thr Ile 
            180                 185                 190         


Arg Lys Thr His Ser Ser Ser Thr Ile Ser Gln Arg Pro Tyr Arg Asp 
        195                 200                 205             


Arg Val Ile His Leu Leu Ala Leu Lys Ala Tyr Lys Lys Pro Glu Leu 
    210                 215                 220                 


Leu Ala Arg Leu Gln Lys Asp Gly Val Asn Gln Lys Asp Lys Asn Ser 
225                 230                 235                 240 


Leu Gly Ala Ile Leu Gln Gln Val Ala Asn Leu Asn Ser Lys Asp Leu 
                245                 250                 255     


Ser Tyr Thr Leu Lys Asp Tyr Val Phe Lys Glu Leu Gln Arg Asp Trp 
            260                 265                 270         


Pro Gly Tyr Ser Glu Ile Asp Arg Arg Ser Leu Glu Ser Val Leu Ser 
        275                 280                 285             


Arg Lys Leu Asn Pro Ser Gln Asn Ala Ala Gly Thr Ser Arg Ser Glu 
    290                 295                 300                 


Ser Pro Val Cys Ser Ser Arg Asp Ala Val Ser Ser Pro Gln Lys Arg 
305                 310                 315                 320 


Leu Leu Asp Ser Glu Phe Ile Asp Pro Leu Met Asn Lys Lys Ala Arg 
                325                 330                 335     


Ile Ser His Leu Thr Asn Arg Val Pro Pro Thr Leu Asn Gly His Leu 
            340                 345                 350         


Asn Pro Thr Ser Glu Lys Ser Ala Ala Gly Leu Pro Leu Pro Pro Ala 
        355                 360                 365             


Ala Ala Ala Ile Pro Thr Pro Pro Pro Leu Pro Ser Thr Tyr Leu Pro 
    370                 375                 380                 


Ile Ser His Pro Pro Gln Ile Val Asn Ser Asn Ser Asn Ser Pro Ser 
385                 390                 395                 400 


Thr Pro Glu Gly Arg Gly Thr Gln Asp Leu Pro Val Asp Ser Phe Ser 
                405                 410                 415     


Gln Asn Asp Ser Ile Tyr Glu Asp Gln Gln Asp Lys Tyr Thr Ser Arg 
            420                 425                 430         


Thr Ser Leu Glu Thr Leu Pro Pro Gly Ser Val Leu Leu Lys Cys Pro 
        435                 440                 445             


Lys Pro Met Glu Glu Asn His Ser Met Ser His Lys Lys Ser Lys Lys 
    450                 455                 460                 


Lys Ser Lys Lys His Lys Glu Lys Asp Gln Ile Lys Lys His Asp Ile 
465                 470                 475                 480 


Glu Thr Ile Glu Glu Lys Glu Glu Asp Leu Lys Arg Glu Glu Glu Ile 
                485                 490                 495     


Ala Lys Leu Asn Asn Ser Ser Pro Asn Ser Ser Gly Gly Val Lys Glu 
            500                 505                 510         


Asp Cys Thr Ala Ser Met Glu Pro Ser Ala Ile Glu Leu Pro Asp Tyr 
        515                 520                 525             


Leu Ile Lys Tyr Ile Ala Ile Val Ser Tyr Glu Gln Arg Gln Asn Tyr 
    530                 535                 540                 


Lys Asp Asp Phe Asn Ala Glu Tyr Asp Glu Tyr Arg Ala Leu His Ala 
545                 550                 555                 560 


Arg Met Glu Thr Val Ala Arg Arg Phe Ile Lys Leu Asp Ala Gln Arg 
                565                 570                 575     


Lys Arg Leu Ser Pro Gly Ser Lys Glu Tyr Gln Asn Val His Glu Glu 
            580                 585                 590         


Val Leu Gln Glu Tyr Gln Lys Ile Lys Gln Ser Ser Pro Asn Tyr His 
        595                 600                 605             


Glu Glu Lys Tyr Arg Cys Glu Tyr Leu His Asn Lys Leu Ala His Ile 
    610                 615                 620                 


Lys Arg Leu Ile Gly Glu Phe Asp Gln Gln Gln Ala Glu Ser Trp Ser 
625                 630                 635                 640 


<210>  73
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Lys Lys Arg Lys Glu Leu Asn Ala Leu Ile Gly Leu Ala Gly Asp 
1               5                   10                  15      


Ser Arg Arg Lys Lys Pro Lys Lys Gly Pro Ser Ser His Arg Leu Leu 
            20                  25                  30          


Arg Thr Glu Pro Pro Asp Ser Asp Ser Glu Ser Ser Ser Glu Glu Glu 
        35                  40                  45              


Glu Glu Phe Gly Val Val Gly Asn Arg Ser Arg Phe Ala Lys Gly Asp 
    50                  55                  60                  


Tyr Leu Arg Cys Cys Lys Ile Cys Tyr Pro Leu Cys Gly Phe Val Ile 
65                  70                  75                  80  


Leu Ala Ala Cys Val Val Ala Cys Val Gly Leu Val Trp Met Gln Val 
                85                  90                  95      


Ala Leu Lys Glu Asp Leu Asp Ala Leu Lys Glu Lys Phe Arg Thr Met 
            100                 105                 110         


Glu Ser Asn Gln Lys Ser Ser Phe Gln Glu Ile Pro Lys Leu Asn Glu 
        115                 120                 125             


Glu Leu Leu Ser Lys Gln Lys Gln Leu Glu Lys Ile Glu Ser Gly Glu 
    130                 135                 140                 


Met Gly Leu Asn Lys Val Trp Ile Asn Ile Thr Glu Met Asn Lys Gln 
145                 150                 155                 160 


Ile Ser Leu Leu Thr Ser Ala Val Asn His Leu Lys Ala Asn Val Lys 
                165                 170                 175     


Ser Ala Ala Asp Leu Ile Ser Leu Pro Thr Thr Val Glu Gly Leu Gln 
            180                 185                 190         


Lys Ser Val Ala Ser Ile Gly Asn Thr Leu Asn Ser Val His Leu Ala 
        195                 200                 205             


Val Glu Ala Leu Gln Lys Thr Val Asp Glu His Lys Lys Thr Met Glu 
    210                 215                 220                 


Leu Leu Gln Ser Asp Met Asn Gln His Phe Leu Lys Glu Thr Pro Gly 
225                 230                 235                 240 


Ser Asn Gln Ile Ile Pro Ser Pro Ser Ala Thr Ser Glu Leu Asp Asn 
                245                 250                 255     


Lys Thr His Ser Glu Asn Leu Lys Gln Asp Ile Leu Tyr Leu His Asn 
            260                 265                 270         


Ser Leu Glu Glu Val Asn Ser Ala Leu Val Gly Tyr Gln Arg Gln Asn 
        275                 280                 285             


Asp Leu Lys Leu Glu Gly Met Asn Glu Thr Val Ser Asn Leu Thr Gln 
    290                 295                 300                 


Arg Val Asn Leu Ile Glu Ser Asp Val Val Ala Met Ser Lys Val Glu 
305                 310                 315                 320 


Lys Lys Ala Asn Leu Ser Phe Ser Met Met Gly Asp Arg Ser Ala Thr 
                325                 330                 335     


Leu Lys Arg Gln Ser Leu Asp Gln Val Thr Asn Arg Thr Asp Thr Val 
            340                 345                 350         


Lys Ile Gln Ser Ile Lys Lys Glu Asp Ser Ser Asn Ser Gln Val Ser 
        355                 360                 365             


Lys Leu Arg Glu Lys Leu Gln Leu Ile Ser Ala Leu Thr Asn Lys Pro 
    370                 375                 380                 


Glu Ser Asn Arg Pro Pro Glu Thr Ala Asp Glu Glu Gln Val Glu Ser 
385                 390                 395                 400 


Phe Thr Ser Lys Pro Ser Ala Leu Pro Lys Phe Ser Gln Phe Leu Gly 
                405                 410                 415     


Asp Pro Val Glu Lys Ala Ala Gln Leu Arg Pro Ile Ser Leu Pro Gly 
            420                 425                 430         


Val Ser Ser Thr Glu Asp Leu Gln Asp Leu Phe Arg Lys Thr Gly Gln 
        435                 440                 445             


Asp Val Asp Gly Lys Leu Thr Tyr Gln Glu Ile Trp Thr Ser Leu Gly 
    450                 455                 460                 


Ser Ala Met Pro Glu Pro Glu Ser Leu Arg Ala Phe Asp Ser Asp Gly 
465                 470                 475                 480 


Asp Gly Arg Tyr Ser Phe Leu Glu Leu Arg Val Ala Leu Gly Ile 
                485                 490                 495 


<210>  74
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Ser Gly Ala Ala Arg Trp Leu Val Leu Ala Pro Val Arg Ser 
1               5                   10                  15      


Gly Ala Leu Arg Ser Gly Pro Ser Leu Arg Lys Asp Gly Asp Val Ser 
            20                  25                  30          


Ala Ala Trp Ser Gly Ser Gly Arg Ser Leu Val Pro Ser Arg Ser Val 
        35                  40                  45              


Ile Val Thr Arg Ser Gly Ala Ile Leu Pro Lys Pro Val Lys Met Ser 
    50                  55                  60                  


Phe Gly Leu Leu Arg Val Phe Ser Ile Val Ile Pro Phe Leu Tyr Val 
65                  70                  75                  80  


Gly Thr Leu Ile Ser Lys Asn Phe Ala Ala Leu Leu Glu Glu His Asp 
                85                  90                  95      


Ile Phe Val Pro Glu Asp Asp Asp Asp Asp Asp 
            100                 105         


<210>  75
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ser Thr Asn Glu Asn Ala Asn Thr Pro Ala Ala Arg Leu His Arg 
1               5                   10                  15      


Phe Lys Asn Lys Gly Lys Asp Ser Thr Glu Met Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Val Asn Val Glu Leu Arg Lys Ala Lys Lys Asp Asp Gln Met Leu 
        35                  40                  45              


Lys Arg Arg Asn Val Ser Ser Phe Pro Asp Asp Ala Thr Ser Pro Leu 
    50                  55                  60                  


Gln Glu Asn Arg Asn Asn Gln Gly Thr Val Asn Trp Ser Val Asp Asp 
65                  70                  75                  80  


Ile Val Lys Gly Ile Asn Ser Ser Asn Val Glu Asn Gln Leu Gln Ala 
                85                  90                  95      


Thr Gln Ala Ala Arg Lys Leu Leu Ser Arg Glu Lys Gln Pro Pro Ile 
            100                 105                 110         


Asp Asn Ile Ile Arg Ala Gly Leu Ile Pro Lys Phe Val Ser Phe Leu 
        115                 120                 125             


Gly Arg Thr Asp Cys Ser Pro Ile Gln Phe Glu Ser Ala Trp Ala Leu 
    130                 135                 140                 


Thr Asn Ile Ala Ser Gly Thr Ser Glu Gln Thr Lys Ala Val Val Asp 
145                 150                 155                 160 


Gly Gly Ala Ile Pro Ala Phe Ile Ser Leu Leu Ala Ser Pro His Ala 
                165                 170                 175     


His Ile Ser Glu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala Gly Asp 
            180                 185                 190         


Gly Ser Val Phe Arg Asp Leu Val Ile Lys Tyr Gly Ala Val Asp Pro 
        195                 200                 205             


Leu Leu Ala Leu Leu Ala Val Pro Asp Met Ser Ser Leu Ala Cys Gly 
    210                 215                 220                 


Tyr Leu Arg Asn Leu Thr Trp Thr Leu Ser Asn Leu Cys Arg Asn Lys 
225                 230                 235                 240 


Asn Pro Ala Pro Pro Ile Asp Ala Val Glu Gln Ile Leu Pro Thr Leu 
                245                 250                 255     


Val Arg Leu Leu His His Asp Asp Pro Glu Val Leu Ala Asp Thr Cys 
            260                 265                 270         


Trp Ala Ile Ser Tyr Leu Thr Asp Gly Pro Asn Glu Arg Ile Gly Met 
        275                 280                 285             


Val Val Lys Thr Gly Val Val Pro Gln Leu Val Lys Leu Leu Gly Ala 
    290                 295                 300                 


Ser Glu Leu Pro Ile Val Thr Pro Ala Leu Arg Ala Ile Gly Asn Ile 
305                 310                 315                 320 


Val Thr Gly Thr Asp Glu Gln Thr Gln Val Val Ile Asp Ala Gly Ala 
                325                 330                 335     


Leu Ala Val Phe Pro Ser Leu Leu Thr Asn Pro Lys Thr Asn Ile Gln 
            340                 345                 350         


Lys Glu Ala Thr Trp Thr Met Ser Asn Ile Thr Ala Gly Arg Gln Asp 
        355                 360                 365             


Gln Ile Gln Gln Val Val Asn His Gly Leu Val Pro Phe Leu Val Ser 
    370                 375                 380                 


Val Leu Ser Lys Ala Asp Phe Lys Thr Gln Lys Glu Ala Val Trp Ala 
385                 390                 395                 400 


Val Thr Asn Tyr Thr Ser Gly Gly Thr Val Glu Gln Ile Val Tyr Leu 
                405                 410                 415     


Val His Cys Gly Ile Ile Glu Pro Leu Met Asn Leu Leu Thr Ala Lys 
            420                 425                 430         


Asp Thr Lys Ile Ile Leu Val Ile Leu Asp Ala Ile Ser Asn Ile Phe 
        435                 440                 445             


Gln Ala Ala Glu Lys Leu Gly Glu Thr Glu Lys Leu Ser Ile Met Ile 
    450                 455                 460                 


Glu Glu Cys Gly Gly Leu Asp Lys Ile Glu Ala Leu Gln Asn His Glu 
465                 470                 475                 480 


Asn Glu Ser Val Tyr Lys Ala Ser Leu Ser Leu Ile Glu Lys Tyr Phe 
                485                 490                 495     


Ser Val Glu Glu Glu Glu Asp Gln Asn Val Val Pro Glu Thr Thr Ser 
            500                 505                 510         


Glu Gly Tyr Thr Phe Gln Val Gln Asp Gly Ala Pro Gly Thr Phe Asn 
        515                 520                 525             


Phe 
    


<210>  76
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Thr Val Arg Pro Pro Arg Pro Ser Leu Leu Leu Val Ser Thr 
1               5                   10                  15      


Arg Glu Ser Cys Leu Phe Leu Leu Phe Cys Leu His Leu Gly Ala Ala 
            20                  25                  30          


Cys Pro Gln Pro Cys Arg Cys Pro Asp His Ala Gly Ala Val Ala Val 
        35                  40                  45              


Phe Cys Ser Leu Arg Gly Leu Gln Glu Val Pro Glu Asp Ile Pro Ala 
    50                  55                  60                  


Asn Thr Val Leu Leu Lys Leu Asp Ala Asn Lys Ile Ser His Leu Pro 
65                  70                  75                  80  


Asp Gly Ala Phe Gln His Leu His Arg Leu Arg Glu Leu Asp Leu Ser 
                85                  90                  95      


His Asn Ala Ile Glu Ala Ile Gly Ser Ala Thr Phe Ala Gly Leu Ala 
            100                 105                 110         


Gly Gly Leu Arg Leu Leu Asp Leu Ser Tyr Asn Arg Ile Gln Arg Ile 
        115                 120                 125             


Pro Lys Asp Ala Leu Gly Lys Leu Ser Ala Lys Ile Arg Leu Ser His 
    130                 135                 140                 


Asn Pro Leu His Cys Glu Cys Ala Leu Gln Glu Ala Leu Trp Glu Leu 
145                 150                 155                 160 


Lys Leu Asp Pro Asp Ser Val Asp Glu Ile Ala Cys His Thr Ser Val 
                165                 170                 175     


Gln Glu Glu Phe Val Gly Lys Pro Leu Val Gln Ala Leu Asp Ala Gly 
            180                 185                 190         


Ala Ser Leu Cys Ser Val Pro His Arg Thr Thr Asp Val Ala Met Leu 
        195                 200                 205             


Val Thr Met Phe Gly Trp Phe Ala Met Val Ile Ala Tyr Val Val Tyr 
    210                 215                 220                 


Tyr Val Arg His Asn Gln Glu Asp Ala Arg Arg His Leu Glu Tyr Leu 
225                 230                 235                 240 


Lys Ser Leu Pro Ser Ala Pro Ala Ser Lys Asp Pro Ile Gly Pro Gly 
                245                 250                 255     


Pro 
    


<210>  77
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Glu Leu Pro Gly Pro Phe Leu Cys Gly Ala Leu Leu Gly Phe 
1               5                   10                  15      


Leu Cys Leu Ser Gly Leu Ala Val Glu Val Lys Val Pro Thr Glu Pro 
            20                  25                  30          


Leu Ser Thr Pro Leu Gly Lys Thr Ala Glu Leu Thr Cys Thr Tyr Ser 
        35                  40                  45              


Thr Ser Val Gly Asp Ser Phe Ala Leu Glu Trp Ser Phe Val Gln Pro 
    50                  55                  60                  


Gly Lys Pro Ile Ser Glu Ser His Pro Ile Leu Tyr Phe Thr Asn Gly 
65                  70                  75                  80  


His Leu Tyr Pro Thr Gly Ser Lys Ser Lys Arg Val Ser Leu Leu Gln 
                85                  90                  95      


Asn Pro Pro Thr Val Gly Val Ala Thr Leu Lys Leu Thr Asp Val His 
            100                 105                 110         


Pro Ser Asp Thr Gly Thr Tyr Leu Cys Gln Val Asn Asn Pro Pro Asp 
        115                 120                 125             


Phe Tyr Thr Asn Gly Leu Gly Leu Ile Asn Leu Thr Val Leu Val Pro 
    130                 135                 140                 


Pro Ser Asn Pro Leu Cys Ser Gln Ser Gly Gln Thr Ser Val Gly Gly 
145                 150                 155                 160 


Ser Thr Ala Leu Arg Cys Ser Ser Ser Glu Gly Ala Pro Lys Pro Val 
                165                 170                 175     


Tyr Asn Trp Val Arg Leu Gly Thr Phe Pro Thr Pro Ser Pro Gly Ser 
            180                 185                 190         


Met Val Gln Asp Glu Val Ser Gly Gln Leu Ile Leu Thr Asn Leu Ser 
        195                 200                 205             


Leu Thr Ser Ser Gly Thr Tyr Arg Cys Val Ala Thr Asn Gln Met Gly 
    210                 215                 220                 


Ser Ala Ser Cys Glu Leu Thr Leu Ser Val Thr Glu Pro Ser Gln Gly 
225                 230                 235                 240 


Arg Val Ala Gly Ala Leu Ile Gly Val Leu Leu Gly Val Leu Leu Leu 
                245                 250                 255     


Ser Val Ala Ala Phe Cys Leu Val Arg Phe Gln Lys Glu Arg Gly Lys 
            260                 265                 270         


Lys Pro Lys Glu Thr Tyr Gly Gly Ser Asp Leu Arg Glu Asp Ala Ile 
        275                 280                 285             


Ala Pro Gly Ile Ser Glu His Thr Cys Met Arg Ala Asp Ser Ser Lys 
    290                 295                 300                 


Gly Phe Leu Glu Arg Pro Ser Ser Ala Ser Thr Val Thr Thr Thr Lys 
305                 310                 315                 320 


Ser Lys Leu Pro Met Val Val 
                325         


<210>  78
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Ala Phe Pro His Lys Ile Ile Phe Phe Leu Val Cys Ser Thr 
1               5                   10                  15      


Leu Thr His Val Ala Phe Ser Gly Ile Phe Asn Lys Arg Asp Phe Thr 
            20                  25                  30          


Arg Trp Pro Lys Pro Arg Cys Lys Met Tyr Ile Pro Leu Asp Pro Asp 
        35                  40                  45              


Tyr Asn Ala Asp Cys Pro Asn Val Thr Ala Pro Val Cys Ala Ser Asn 
    50                  55                  60                  


Gly His Thr Phe Gln Asn Glu Cys Phe Phe Cys Val Glu Gln Arg Glu 
65                  70                  75                  80  


Phe His Tyr Arg Ile Lys Phe Glu Lys Tyr Gly Lys Cys Asp 
                85                  90                  


<210>  79
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 
    210                 215                 220                 


Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 
225                 230                 235                 240 


Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 
                245                 250                 255     


Val Gln Asn 
            


<210>  80
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Lys Leu Leu Leu Leu Thr Leu Thr Val Leu Leu Leu Leu Ser Gln 
1               5                   10                  15      


Leu Thr Pro Gly Gly Thr Gln Arg Cys Trp Asn Leu Tyr Gly Lys Cys 
            20                  25                  30          


Arg Tyr Arg Cys Ser Lys Lys Glu Arg Val Tyr Val Tyr Cys Ile Asn 
        35                  40                  45              


Asn Lys Met Cys Cys Val Lys Pro Lys Tyr Gln Pro Lys Glu Arg Trp 
    50                  55                  60                  


Trp Pro Phe 
65          


<210>  81
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Pro Ile Lys Pro Val Gly Trp Ile Cys Gly Gln Val Leu Lys Asn 
1               5                   10                  15      


Phe Ser Gly Arg Ile Glu Gly Ile Gln Lys Ala Ile Met Asp Leu Val 
            20                  25                  30          


Asp Glu Phe Lys Asp Glu Phe Pro Thr Ile Leu Arg Leu Ser Gln Ser 
        35                  40                  45              


Asn Gln Lys Arg Glu Pro Ala Gln Lys Thr Ser Lys Ile Arg Met Ala 
    50                  55                  60                  


Ile Ala Leu Ala Lys Ile Asn Arg Ala Thr Leu Ile Arg Gly Leu Asn 
65                  70                  75                  80  


Ser Ile Ser Arg Ser Ser Lys Ser Val Ala Lys Leu Leu His Pro Gln 
                85                  90                  95      


Leu Ala Cys Arg Leu Leu Glu Leu Arg Asp Ile Ser Gly Arg Leu Leu 
            100                 105                 110         


Arg Glu Val Asn Ala Pro Arg Gln Pro Leu Tyr Asn Ile Gln Val Arg 
        115                 120                 125             


Lys Gly Ser Leu Phe Glu Ile Ile Ser Phe Pro Ala Lys Thr Ala Leu 
    130                 135                 140                 


Thr Ser Ile Ile Tyr Ala Ser Tyr Ala Ala Leu Ile Tyr Leu Ala Val 
145                 150                 155                 160 


Cys Val Asn Ala Val Leu Lys Lys Val Lys Asn Ile Phe Gln Glu Glu 
                165                 170                 175     


Glu Ser Ile Arg Gln Asn Arg Glu Glu Ser Glu Asn Cys Arg Lys Ala 
            180                 185                 190         


Phe Ser Glu Pro Val Leu Ser Glu Pro Met Phe Ala Glu Gly Glu Ile 
        195                 200                 205             


Lys Ala Lys Pro Tyr Arg Ser Leu Pro Glu Lys Pro Asp Ile Ser Asp 
    210                 215                 220                 


Tyr Pro Lys Leu Leu Ala Asn Lys Gln Ser Asn Asn Ile Gln Val Leu 
225                 230                 235                 240 


His Ser Val Phe Asp Gln Ser Ala Glu Met Asn Glu Gln Ile 
                245                 250                 


<210>  82
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
    450                 455                 460             


<210>  83
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210>  84
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Leu Leu Thr Asn Leu Leu Pro Leu Cys Cys Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Pro Ala Gln Ser Cys Gly Pro Gly Arg Gly Pro Val Gly Arg 
            20                  25                  30          


Arg Arg Tyr Ala Arg Lys Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe 
        35                  40                  45              


Val Pro Gly Val Pro Glu Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu 
    50                  55                  60                  


Gly Arg Val Ala Arg Gly Ser Glu Arg Phe Arg Asp Leu Val Pro Asn 
65                  70                  75                  80  


Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp 
                85                  90                  95      


Arg Leu Met Thr Glu Arg Cys Lys Glu Arg Val Asn Ala Leu Ala Ile 
            100                 105                 110         


Ala Val Met Asn Met Trp Pro Gly Val Arg Leu Arg Val Thr Glu Gly 
        115                 120                 125             


Trp Asp Glu Asp Gly His His Ala Gln Asp Ser Leu His Tyr Glu Gly 
    130                 135                 140                 


Arg Ala Leu Asp Ile Thr Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr 
                165                 170                 175     


Glu Ser Arg Asn His Val His Val Ser Val Lys Ala Asp Asn Ser Leu 
            180                 185                 190         


Ala Val Arg Ala Gly Gly Cys Phe Pro Gly Asn Ala Thr Val Arg Leu 
        195                 200                 205             


Trp Ser Gly Glu Arg Lys Gly Leu Arg Glu Leu His Arg Gly Asp Trp 
    210                 215                 220                 


Val Leu Ala Ala Asp Ala Ser Gly Arg Val Val Pro Thr Pro Val Leu 
225                 230                 235                 240 


Leu Phe Leu Asp Arg Asp Leu Gln Arg Arg Ala Ser Phe Val Ala Val 
                245                 250                 255     


Glu Thr Glu Trp Pro Pro Arg Lys Leu Leu Leu Thr Pro Trp His Leu 
            260                 265                 270         


Val Phe Ala Ala Arg Gly Pro Ala Pro Ala Pro Gly Asp Phe Ala Pro 
        275                 280                 285             


Val Phe Ala Arg Arg Leu Arg Ala Gly Asp Ser Val Leu Ala Pro Gly 
    290                 295                 300                 


Gly Asp Ala Leu Arg Pro Ala Arg Val Ala Arg Val Ala Arg Glu Glu 
305                 310                 315                 320 


Ala Val Gly Val Phe Ala Pro Leu Thr Ala His Gly Thr Leu Leu Val 
                325                 330                 335     


Asn Asp Val Leu Ala Ser Cys Tyr Ala Val Leu Glu Ser His Gln Trp 
            340                 345                 350         


Ala His Arg Ala Phe Ala Pro Leu Arg Leu Leu His Ala Leu Gly Ala 
        355                 360                 365             


Leu Leu Pro Gly Gly Ala Val Gln Pro Thr Gly Met His Trp Tyr Ser 
    370                 375                 380                 


Arg Leu Leu Tyr Arg Leu Ala Glu Glu Leu Leu Gly 
385                 390                 395     


<210>  85
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  86
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Asp Gly Leu Pro Gly Arg Ala Leu Gly Ala Ala Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Gly Trp Leu Gly Pro Glu Ala Trp Gly Ser Pro Thr Pro 
            20                  25                  30          


Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ser Pro 
        35                  40                  45              


Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly Phe Arg Arg Pro 
    50                  55                  60                  


Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu Ala Val Lys Arg 
65                  70                  75                  80  


His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro Asn Ile Thr His 
                85                  90                  95      


Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg Lys Leu His Ala 
            100                 105                 110         


Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro His Leu Asp Gly 
        115                 120                 125             


His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val Ser Glu Ile Ile 
    130                 135                 140                 


Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg Val Arg Leu Tyr 
145                 150                 155                 160 


Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe Val Val Gln Ala 
                165                 170                 175     


Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val Leu Glu Lys Gly 
            180                 185                 190         


Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln Glu Gln Gly His 
        195                 200                 205             


Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp Leu Lys Arg Ser 
    210                 215                 220                 


Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln Ala Leu Phe Glu 
225                 230                 235                 240 


Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys Asp Ser Cys Gln 
                245                 250                 255     


Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly Glu Glu Ser His 
            260                 265                 270         


Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp Ser Arg His Arg 
        275                 280                 285             


Ile Arg Lys Arg Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys 
    290                 295                 300                 


Arg Gln Gln Phe Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp 
305                 310                 315                 320 


Ile Ile Ala Pro Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys 
                325                 330                 335     


Pro Ala Tyr Leu Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr 
            340                 345                 350         


Ala Val Val Asn Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val 
        355                 360                 365             


Asn Ser Cys Cys Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr 
    370                 375                 380                 


Phe Asp Asp Glu Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile 
385                 390                 395                 400 


Val Glu Glu Cys Gly Cys Ala 
                405         


<210>  87
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Arg Arg Leu Leu Ile Pro Leu Ala Leu Trp Leu Gly Ala Val Gly 
1               5                   10                  15      


Val Gly Val Ala Glu Leu Thr Glu Ala Gln Arg Arg Gly Leu Gln Val 
            20                  25                  30          


Ala Leu Glu Glu Phe His Lys His Pro Pro Val Gln Trp Ala Phe Gln 
        35                  40                  45              


Glu Thr Ser Val Glu Ser Ala Val Asp Thr Pro Phe Pro Ala Gly Ile 
    50                  55                  60                  


Phe Val Arg Leu Glu Phe Lys Leu Gln Gln Thr Ser Cys Arg Lys Arg 
65                  70                  75                  80  


Asp Trp Lys Lys Pro Glu Cys Lys Val Arg Pro Asn Gly Arg Lys Arg 
                85                  90                  95      


Lys Cys Leu Ala Cys Ile Lys Leu Gly Ser Glu Asp Lys Val Leu Gly 
            100                 105                 110         


Arg Leu Val His Cys Pro Ile Glu Thr Gln Val Leu Arg Glu Ala Glu 
        115                 120                 125             


Glu His Gln Glu Thr Gln Cys Leu Arg Val Gln Arg Ala Gly Glu Asp 
    130                 135                 140                 


Pro His Ser Phe Tyr Phe Pro Gly Gln Phe Ala Phe Ser Lys Ala Leu 
145                 150                 155                 160 


Pro Arg Ser 
            


<210>  88
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Tyr Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Ser Glu Leu Ser Gly Trp Asp Tyr Glu Tyr Gly Phe Cys 
                325                 330                 335     


Leu Pro Lys Thr Pro Arg Cys Ala Pro Glu Pro Asp Ala Phe Asn Pro 
            340                 345                 350         


Cys Glu Asp Ile Met Gly Tyr Asp Phe Leu Arg Val Leu Ile Trp Leu 
        355                 360                 365             


Ile Asn Ile Leu Ala Ile Met Gly Asn Met Thr Val Leu Phe Val Leu 
    370                 375                 380                 


Leu Thr Ser Arg Tyr Lys Leu Thr Val Pro Arg Phe Leu Met Cys Asn 
385                 390                 395                 400 


Leu Ser Phe Ala Asp Phe Cys Met Gly Leu Tyr Leu Leu Leu Ile Ala 
                405                 410                 415     


Ser Val Asp Ser Gln Thr Lys Gly Gln Tyr Tyr Asn His Ala Ile Asp 
            420                 425                 430         


Trp Gln Thr Gly Ser Gly Cys Ser Thr Ala Gly Phe Phe Thr Val Phe 
        435                 440                 445             


Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val Ile Thr Leu Glu Arg 
    450                 455                 460                 


Trp His Thr Ile Thr Tyr Ala Ile His Leu Asp Gln Lys Leu Arg Leu 
465                 470                 475                 480 


Arg His Ala Ile Leu Ile Met Leu Gly Gly Trp Leu Phe Ser Ser Leu 
                485                 490                 495     


Ile Ala Met Leu Pro Leu Val Gly Val Ser Asn Tyr Met Lys Val Ser 
            500                 505                 510         


Ile Cys Phe Pro Met Asp Val Glu Thr Thr Leu Ser Gln Val Tyr Ile 
        515                 520                 525             


Leu Thr Ile Leu Ile Leu Asn Val Val Ala Phe Phe Ile Ile Cys Ala 
    530                 535                 540                 


Cys Tyr Ile Lys Ile Tyr Phe Ala Val Arg Asn Pro Glu Leu Met Ala 
545                 550                 555                 560 


Thr Asn Lys Asp Thr Lys Ile Ala Lys Lys Met Ala Ile Leu Ile Phe 
                565                 570                 575     


Thr Asp Phe Thr Cys Met Ala Pro Ile Ser Phe Phe Ala Ile Ser Ala 
            580                 585                 590         


Ala Phe Lys Val Pro Leu Ile Thr Val Thr Asn Ser Lys Val Leu Leu 
        595                 600                 605             


Val Leu Phe Tyr Pro Ile Asn Ser Cys Ala Asn Pro Phe Leu Tyr Ala 
    610                 615                 620                 


Ile Phe Thr Lys Thr Phe Gln Arg Asp Phe Phe Leu Leu Leu Ser Lys 
625                 630                 635                 640 


Phe Gly Cys Cys Lys Arg Arg Ala Glu Leu Tyr Arg Arg Lys Asp Phe 
                645                 650                 655     


Ser Ala Tyr Thr Ser Asn Cys Lys Asn Gly Phe Thr Gly Ser Asn Lys 
            660                 665                 670         


Pro Ser Gln Ser Thr Leu Lys Leu Ser Thr Leu His Cys Gln Gly Thr 
        675                 680                 685             


Ala Leu Leu Asp Lys Thr Arg Tyr Thr Glu Cys 
    690                 695                 


<210>  89
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu 
1               5                   10                  15      


Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp 
            20                  25                  30          


Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro 
        35                  40                  45              


Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe 
    50                  55                  60                  


Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn 
                85                  90                  95      


Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val 
            100                 105                 110         


Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu 
        115                 120                 125             


Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr 
    130                 135                 140                 


Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe 
145                 150                 155                 160 


Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln 
                165                 170                 175     


Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly 
            180                 185                 190         


Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser 
        195                 200                 205             


Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu 
    210                 215                 220                 


Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu 
225                 230                 235                 240 


Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala 
                245                 250                 255     


Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser 
            260                 265                 270         


Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg 
        275                 280                 285             


Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser 
    290                 295                 300                 


Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn 
305                 310                 315                 320 


Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr 
                325                 330                 335     


Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala 
            340                 345                 350         


Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser 
        355                 360                 365             


Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg 
    370                 375                 380                 


Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser 
385                 390                 395                 400 


Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg 
                405                 410                 415     


Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys 
            420                 425                 430         


Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys 
        435                 440                 445             


Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp 
    450                 455                 460                 


Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg 
465                 470                 475                 480 


Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu 
                485                 490                 495     


Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp 
            500                 505                 510         


Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn 
        515                 520                 525             


Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp 
    530                 535                 540                 


Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp 
545                 550                 555                 560 


Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys 
                565                 570                 575     


Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp 
            580                 585                 590         


Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val 
        595                 600                 605             


Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser 
    610                 615                 620                 


Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr 
625                 630                 635                 640 


Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys 
                645                 650                 655     


Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile 
            660                 665                 670         


Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn 
        675                 680                 685             


Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu 
    690                 695                 700                 


Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro 
705                 710                 715                 720 


Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val 
                725                 730                 735     


Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
            740                 745                 750         


Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
        755                 760                 765             


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
    770                 775                 780                 


Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
785                 790                 795                 800 


Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr 
                805                 810                 815     


Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro 
            820                 825                 830         


Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His 
        835                 840                 845             


Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg 
    850                 855                 860                 


Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser 
865                 870                 875                 880 


Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val 
                885                 890                 895     


Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile 
            900                 905                 910         


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
        915                 920                 925             


Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile 
    930                 935                 940                 


Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp 
945                 950                 955                 960 


Asn 
    


<210>  90
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  91
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Trp Ser His Leu Asn Arg Leu Leu Phe Trp Ser Ile Phe Ser Ser 
1               5                   10                  15      


Val Thr Cys Arg Lys Ala Val Leu Asp Cys Glu Ala Met Lys Thr Asn 
            20                  25                  30          


Glu Phe Pro Ser Pro Cys Leu Asp Ser Lys Thr Lys Val Val Met Lys 
        35                  40                  45              


Gly Gln Asn Val Ser Met Phe Cys Ser His Lys Asn Lys Ser Leu Gln 
    50                  55                  60                  


Ile Thr Tyr Ser Leu Phe Arg Arg Lys Thr His Leu Gly Thr Gln Asp 
65                  70                  75                  80  


Gly Lys Gly Glu Pro Ala Ile Phe Asn Leu Ser Ile Thr Glu Ala His 
                85                  90                  95      


Glu Ser Gly Pro Tyr Lys Cys Lys Ala Gln Val Thr Ser Cys Ser Lys 
            100                 105                 110         


Tyr Ser Arg Asp Phe Ser Phe Thr Ile Val Asp Pro Val Thr Ser Pro 
        115                 120                 125             


Val Leu Asn Ile Met Val Ile Gln Thr Glu Thr Asp Arg His Ile Thr 
    130                 135                 140                 


Leu His Cys Leu Ser Val Asn Gly Ser Leu Pro Ile Asn Tyr Thr Phe 
145                 150                 155                 160 


Phe Glu Asn His Val Ala Ile Ser Pro Ala Ile Ser Lys Tyr Asp Arg 
                165                 170                 175     


Glu Pro Ala Glu Phe Asn Leu Thr Lys Lys Asn Pro Gly Glu Glu Glu 
            180                 185                 190         


Glu Tyr Arg Cys Glu Ala Lys Asn Arg Leu Pro Asn Tyr Ala Thr Tyr 
        195                 200                 205             


Ser His Pro Val Thr Met Pro Ser Thr Gly Gly Asp Ser Cys Pro Phe 
    210                 215                 220                 


Cys Leu Lys Leu Leu Leu Pro Gly Leu Leu Leu Leu Leu Val Val Ile 
225                 230                 235                 240 


Ile Leu Ile Leu Ala Phe Trp Val Leu Pro Lys Tyr Lys Thr Arg Lys 
                245                 250                 255     


Ala Met Arg Asn Asn Val Pro Arg Asp Arg Gly Asp Thr Ala Met Glu 
            260                 265                 270         


Val Gly Ile Tyr Ala Asn Ile Leu Glu Lys Gln Ala Lys Glu Glu Ser 
        275                 280                 285             


Val Pro Glu Val Gly Ser Arg Pro Cys Val Ser Thr Ala Gln Asp Glu 
    290                 295                 300                 


Ala Lys His Ser Gln Glu Leu Gln Tyr Ala Thr Pro Val Phe Gln Glu 
305                 310                 315                 320 


Val Ala Pro Arg Glu Gln Glu Ala Cys Asp Ser Tyr Lys Ser Gly Tyr 
                325                 330                 335     


Val Tyr Ser Glu Leu Asn Phe 
            340             


