                         SEQUENCE LISTING

<110>  Oxford BioTherapeutics Ltd
 
<120>  Antibodies and Methods of Use

<130>  P1125PC00

<150>  US62/870269
<151>  2019-07-03

<150>  US62/965450
<151>  2020-01-24

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  mus musculus

<400>  1

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  2
<211>  106
<212>  PRT
<213>  mus musculus

<400>  2

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Asn Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  3
<211>  351
<212>  DNA
<213>  mus musculus

<400>  3
caggtgcaac tcaagcaaag cggtgcagaa ctggtgagac ctggcacatc agtcaaggtg       60

tcatgcaaag ctagtggata cgccttcact aactacctga ttgagtgggt gaagcaaaga      120

cctggtcagg gtctggaatg gattggagtg atcaacccag gtagcggagg aactaactac      180

aacgagaagt tcaaggataa ggcaactctg actgccgaca agagctctaa cacagcctat      240

atgcaactgt ccagtctcac tagcgatgat tccgcagtgt acttctgtgc tcgcagaggc      300

tgggactact ttgactactg gggtcaagga actactctga cagtgtccag c               351


<210>  4
<211>  318
<212>  DNA
<213>  mus musculus

<400>  4
cagatcgttc tcacccagag tcctgcactg atgtcaacaa gccctggcga gaaagttaca       60

atgacttgca gtgcatcctc ttccgtttct tacatctatt ggttccagca gaagccaggg      120

agctcaccaa agccttggat ctacagaaca tccaatctcg caagcggtgt tccagctagg      180

ttcagtgggt ccggatcagg cacatcctac tctctgacaa tctcctccat ggaagcagaa      240

gacgctgcaa cctactattg ccaacagtgg gacaacaatc cctacacctt tggaggtggt      300

accaagctgg agatcaag                                                    318


<210>  5
<211>  5
<212>  PRT
<213>  mus musculus

<400>  5

Asn Tyr Leu Ile Glu 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  mus musculus

<400>  6

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  7
<211>  8
<212>  PRT
<213>  mus musculus

<400>  7

Arg Gly Trp Asp Tyr Phe Asp Tyr 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  mus musculus

<400>  8

Ser Ala Ser Ser Ser Val Ser Tyr Ile Tyr 
1               5                   10  


<210>  9
<211>  7
<212>  PRT
<213>  mus musculus

<400>  9

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  mus musculus

<400>  10

Gln Gln Trp Asp Asn Asn Pro Tyr Thr 
1               5                   


<210>  11
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Trp Leu Phe Gln Ser Leu Leu Phe Val Phe Cys Phe Gly Pro 
1               5                   10                  15      


Gly Asn Val Val Ser Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly 
            20                  25                  30          


Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu 
        35                  40                  45              


Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe 
    50                  55                  60                  


Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro 
65                  70                  75                  80  


Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu 
                85                  90                  95      


Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser 
            100                 105                 110         


Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg 
        115                 120                 125             


Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn 
    130                 135                 140                 


Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp 
145                 150                 155                 160 


Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln 
                165                 170                 175     


Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp 
            180                 185                 190         


Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val 
        195                 200                 205             


Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr 
    210                 215                 220                 


Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe 
225                 230                 235                 240 


Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser 
                245                 250                 255     


Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu 
            260                 265                 270         


Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val 
        275                 280                 285             


Thr His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp 
    290                 295                 300                 


Thr Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro 
305                 310                 315                 320 


Thr Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val 
                325                 330         


<210>  12
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly Ile Leu Gly Glu Ser 
1               5                   10                  15      


Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu Lys Val Asn Phe Ile 
            20                  25                  30          


Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe Ile Val Pro His Glu 
        35                  40                  45              


Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro Lys Gln Gly Lys Arg 
    50                  55                  60                  


Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu Ser Asn Leu Lys Met 
65                  70                  75                  80  


Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser Thr Lys Thr Ser Ala 
                85                  90                  95      


Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg Gln Leu Arg Asn Ile 
            100                 105                 110         


Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn Met Thr Cys Glu Leu 
        115                 120                 125             


His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp Asn Val Ser Phe Arg 
    130                 135                 140                 


Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln Pro Asn Leu Thr Val 
145                 150                 155                 160 


Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp Tyr Thr Cys Ile Ala 
                165                 170                 175     


Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val Ser Ala Gln Lys Leu 
            180                 185                 190         


Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr Lys Met 
        195                 200                 205 


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  14

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Asn Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised CDR sequence

<400>  15

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised CDR sequence

<400>  16

Gln Ala Ser Gln Asp Val Ser Tyr Ile Tyr 
1               5                   10  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised CDR sequence

<400>  17

Arg Thr Ser Asn Leu Ala Thr 
1               5           


<210>  18
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  19
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  19

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Asn Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  20
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  20
caagtgcaac tggtgcaatc tggtgctgaa gtcaagaagc ctggtgcttc cgtcaaggtt       60

tcttgtaagg catctggtta cgcattcacc aactatctca ttgaatgggt taggcaagca      120

cctggacaag gactggagtg gatcggagtg atcaacccag gttctggagg cacaaactac      180

aacgagaagt tccaaggtcg cgtcacactc actgcagaca aatccatttc tacagcctac      240

atggagctgt ctcgcctccg ctccgatgac actgctgtgt actactgcgc tcgcagaggt      300

tgggactact tcgactactg gggtcaaggt accctcgtta cagtgtccag c               351


<210>  21
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  21
gacatccaac tgactcaatc tccatctagc ctgtctgcat ccgttggtga tagggtcact       60

atcacatgcc aagcatctca agacgtgagc tacatctatt ggtatcaaca gaaacccggt      120

aaggctccta aaccttggat ctacaggaca tctaatctgg ccactggtgt tccttctcgc      180

ttctctggca gcggtagcgg aaccgactac actttcacca tcagctctct ccaacctgaa      240

gacattgcta cctactactg tcagcaatgg gataacaacc catacacctt tggacaaggt      300

accaagctgg agatcaag                                                    318


<210>  22
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  22
caagtgcaac tggtgcaatc tggtgctgaa gtcaagaagc ctggtgcttc cgtcaaggtt       60

tcttgtaagg catctggtta cgcattcacc aactatctca ttgaatgggt taggcaagca      120

cctggacaag gactggagtg gatcggagtg atcaacccag gttctggagg cacaaactac      180

aacgagaagt tccaaggtcg cgtcacactc actgcagaca aatccatttc tacagcctac      240

atggagctgt ctcgcctccg ctccgatgac actgctgtgt actactgcgc tcgcagaggt      300

tgggactact tcgactactg gggtcaaggt accctcgtta cagtgtccag cgctagcacc      360

aagggcccat ccgttttccc tctggctcct agctccaaat caaccagcgg tggcacagca      420

gccctgggat gtctcgtgaa ggactacttc cccgagcccg tcaccgtctc ctggaactcc      480

ggcgcactca cctccggcgt ccacaccttt cccgccgttc tgcagagttc tggcctgtac      540

agtctgagtt ccgtggtgac cgtcccatcc tcctccctcg ggacccagac ctacatttgt      600

aatgttaatc acaagccatc aaacaccaaa gtggataaga aggtcgaacc taaaagctgc      660

gacaagactc acacctgccc accctgcccc gcaccagaag ctgcaggtgg cccctcagtt      720

ttcctgttcc caccaaagcc caaagatacc ctcatgatct caagaacccc agaggtcacc      780

tgcgtcgtcg tcgacgtgtc acacgaagat cccgaagtca agtttaattg gtatgttgat      840

ggggtcgaag tgcataacgc caaaacaaaa ccccgcgaag agcagtataa cagcacttac      900

agagttgttt ccgttctgac agtgctccac caggattggc tgaatggtaa ggagtacaaa      960

tgcaaggtgt ctaacaaggc tctgccagcc cctattgaga aaaccataag caaggccaag     1020

ggtcagccca gggagccaca ggtgtatacc ctcccacctt cacgggatga gctgaccaag     1080

aaccaagtga gtctcacctg tctggtgaag ggcttctacc caagcgatat tgctgtggaa     1140

tgggaatcta acgggcagcc tgaaaataac tacaagacca caccaccagt gctcgattcc     1200

gacggtagct tctttctgta ttccaaactg accgtggaca aaagcagatg gcagcaggga     1260

aatgtgttca gttgtagcgt gatgcatgag gccctccaca accactacac acagaagagc     1320

ctctccctgt ctcccggtaa g                                               1341


<210>  23
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanised antibody sequence

<400>  23
gacatccaac tgactcaatc tccatctagc ctgtctgcat ccgttggtga tagggtcact       60

atcacatgcc aagcatctca agacgtgagc tacatctatt ggtatcaaca gaaacccggt      120

aaggctccta aaccttggat ctacaggaca tctaatctgg ccactggtgt tccttctcgc      180

ttctctggca gcggtagcgg aaccgactac actttcacca tcagctctct ccaacctgaa      240

gacattgcta cctactactg tcagcaatgg gataacaacc catacacctt tggacaaggt      300

accaagctgg agatcaagag aacagtggct gcacctagtg tgttcatctt ccctccttcc      360

gatgagcaac tgaagagcgg aaccgccagt gttgtctgtc tgctgaacaa cttctaccct      420

cgggaagcca aagttcagtg gaaagtcgac aacgctctgc aatccggcaa ctcccaggag      480

agtgtcacag agcaagattc caaggactcc acatatagtc tgtcctctac tctgactctg      540

agcaaggctg actacgagaa gcacaaagtg tacgcttgcg aagtgacaca tcaaggcctg      600

tccagtcccg ttaccaagag cttcaataga ggagaatgt                             639


