                         б

<110>  ݿƼ޹˾
 
<120>  տȶؽϵ

<130>  P2020TC1158

<150>  201910584155.7
<151>  2019-07-01

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT3 CDR1

<400>  1

Gly Tyr Thr Val Ser Ser Ile Cys Met Gly 
1               5                   10  


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT3 CDR2

<400>  2

Ala Val Ala Ser Asp Gly Val Thr Ser Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT3 CDR3

<400>  3

Arg Lys Arg Gly Tyr Cys Ser Leu Asp Arg Thr Phe Phe Thr Trp 
1               5                   10                  15  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7 CDR1

<400>  4

Gly Tyr Thr Tyr Ser Ser Tyr Cys Met Gly 
1               5                   10  


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7 CDR2

<400>  5

Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7 CDR3

<400>  6

Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala Asp 
1               5                   10                  15      


Phe Gly Tyr 
            


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12 CDR1

<400>  7

Gly Tyr Thr Tyr Ser Ser Tyr Cys Met Gly 
1               5                   10  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12 CDR2

<400>  8

Gly Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12 CDR3

<400>  9

Gln Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly Ala 
1               5                   10                  15      


Asp Phe Gly Tyr 
            20  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT13 CDR1

<400>  10

Gly Tyr Arg Ser Cys Met Gly 
1               5           


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT13 CDR2

<400>  11

Ala Ile Trp Pro Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT13 CDR3

<400>  12

Ala Asp Leu Ile Cys Pro Thr Asp Trp Ala Gln Arg Leu Gln Tyr Asn 
1               5                   10                  15      


Tyr 
    


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15 CDR1

<400>  13

Gly Tyr Thr Tyr Gly Ser Tyr Cys Met Ala 
1               5                   10  


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15 CDR2

<400>  14

Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15 CDR3

<400>  15

Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu 
1               5                   10                  15      


Phe Met Tyr Glu Phe Ala Tyr 
            20              


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT20 CDR1

<400>  16

Glu Tyr Arg Tyr Cys Met Ala 
1               5           


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT20 CDR2

<400>  17

Gly Ile Tyr Ile Gly Asp Arg Thr Val Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT20 CDR3

<400>  18

Val Asp Leu Ile Cys Pro Ser Asp Trp Ala Gln Arg Leu Gln Tyr Gln 
1               5                   10                  15      


Tyr 
    


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT21 CDR1

<400>  19

Gly Tyr Pro Tyr Ser Arg Asn Cys Met Ala 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT21 CDR2

<400>  20

Thr Ile Tyr Asn Gly Asp Gly Thr Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT21 CDR3

<400>  21

Ala Arg Gly Cys Ser Leu Arg Thr Trp Ser Asp Gln Asn Leu Tyr Ala 
1               5                   10                  15      


Tyr 
    


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT22 CDR1

<400>  22

Asp Ile Thr Tyr Ser Arg Cys Met Ala 
1               5                   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT22 CDR2

<400>  23

Ala Leu Ser Thr Asn Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT22 CDR3

<400>  24

Ser Ser Phe Phe Ser Cys Arg Asp Cys Ser Gly Gly Asp Cys Pro Arg 
1               5                   10                  15      


Ser Arg Asp Tyr Lys Tyr 
            20          


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT26 CDR1

<400>  25

Gly Phe Thr Thr Ser Ser Arg Cys Met Ala 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT26 CDR2

<400>  26

Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT26 CDR3

<400>  27

Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Lys Arg Asp Val Asn 
1               5                   10                  15      


Tyr 
    


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT28 CDR1

<400>  28

Gly Tyr Thr Tyr Thr Ser Tyr Cys Met Gly 
1               5                   10  


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT28 CDR2

<400>  29

Gly Ile Asp Arg Asp Gly Ile Ala Val Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT28 CDR3

<400>  30

Asp Tyr Arg Arg Trp Cys Arg Asp Glu Tyr Glu Tyr 
1               5                   10          


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT35 CDR1

<400>  31

Thr Tyr Thr Thr Thr Ser Arg Cys Met Ala 
1               5                   10  


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT35 CDR2

<400>  32

Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT35 CDR3

<400>  33

Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Thr Arg Asp Val Asn 
1               5                   10                  15      


Tyr 
    


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT36 CDR1

<400>  34

Glu Tyr Arg Ser Cys Met Gly 
1               5           


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT36 CDR2

<400>  35

Ala Ile Trp Pro Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT36 CDR3

<400>  36

Ala Glu Leu Ile Cys Pro Thr Asp Trp Ala Gln Arg Gln Gln Tyr Asn 
1               5                   10                  15      


Tyr 
    


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT42 CDR1

<400>  37

Gly Tyr Thr Tyr Ser Asp Val Cys Met Gly 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT42 CDR2

<400>  38

Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT42 CDR3

<400>  39

Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly Phe 
1               5                   10                  15      


<210>  40
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT3

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Tyr Thr Val Ser Ser Ile 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Val Ala Ser Asp Gly Val Thr Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Lys Arg Gly Tyr Cys Ser Leu Asp Arg Thr Phe Phe Thr Trp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  41
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  42
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Asp Asn Val Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly 
            100                 105                 110         


Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  43
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT13

<400>  43

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Tyr Arg Ser Cys Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile 
        35                  40                  45              


Trp Pro Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Lys Ala Val Asn Thr Met Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Ala Asp 
                85                  90                  95      


Leu Ile Cys Pro Thr Asp Trp Ala Gln Arg Leu Gln Tyr Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  44
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  45
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT20

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Arg Tyr Cys Met Ala 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Gly Ile 
        35                  40                  45              


Tyr Ile Gly Asp Arg Thr Val Tyr Ser Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Gln Asp Asn Ala Asp Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Val Asp 
                85                  90                  95      


Leu Ile Cys Pro Ser Asp Trp Ala Gln Arg Leu Gln Tyr Gln Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  46
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT21

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Pro Tyr Ser Arg Asn 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Glu Lys Gln Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Tyr Asn Gly Asp Gly Thr Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Gly Cys Ser Leu Arg Thr Trp Ser Asp Gln Asn Leu 
            100                 105                 110         


Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  47
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT22

<400>  47

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Thr Asp Ile Thr Tyr Ser Arg Cys 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Ser Arg Glu Gly Val Ala 
        35                  40                  45              


Ala Leu Ser Thr Asn Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Asp Ser Ser Phe Phe Ser Cys Arg Asp Cys Ser Gly Gly Asp Cys Pro 
            100                 105                 110         


Arg Ser Arg Asp Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  48
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT26

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Thr Ser Ser Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Gly Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Met Trp 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Lys Arg Asp 
            100                 105                 110         


Val Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  49
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT28

<400>  49

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Thr Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Asp Arg Asp Gly Ile Ala Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Lys Asp Asn Val Glu Asp Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Tyr Arg Arg Trp Cys Arg Asp Glu Tyr Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  50
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT35

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Tyr Thr Thr Thr Ser Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Gly Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Thr Ala Lys Asn Thr Met Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Thr Arg Asp 
            100                 105                 110         


Val Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  51
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT36

<400>  51

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Glu Tyr Arg Ser Cys Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile 
        35                  40                  45              


Trp Pro Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Lys Asp Val Asn Thr Met Tyr Leu Ala Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Ala Glu 
                85                  90                  95      


Leu Ile Cys Pro Thr Asp Trp Ala Gln Arg Gln Gln Tyr Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  52
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT42

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V1

<400>  53

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  54
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V2

<400>  54

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  55
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V3

<400>  55

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  56
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V4

<400>  56

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  57
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V5

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  58
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V6

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  59
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V7

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  60
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V8

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  61
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V9

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  62
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7V10

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  63
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT7v11

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  64
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V1

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  65
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V2

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  66
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V3

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  67
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V4

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  68
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V5

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  69
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V6

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  70
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V7

<400>  70

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  71
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V8

<400>  71

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  72
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V9

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  73
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V10

<400>  73

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  74
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT15V11

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  75
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V1

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  76
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V2

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  77
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V3

<400>  77

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  78
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V4

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  79
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V5

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V6

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  81
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V7

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  82
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V8

<400>  82

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  83
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V9

<400>  83

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  84
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V10

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  85
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huPT42V11

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  86
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1-FC

<400>  86

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  87
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7n15

<400>  87

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys 
145                 150                 155                 160 


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                165                 170                 175     


Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu 
225                 230                 235                 240 


Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  88
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15n7

<400>  88

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr 
145                 150                 155                 160 


Ser Ser Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp 
            180                 185                 190         


Phe Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr 
        195                 200                 205             


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
    210                 215                 220                 


Tyr Cys Ala Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys 
225                 230                 235                 240 


Gly Gly Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  89
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7n22

<400>  89

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    130                 135                 140                 


Leu Gln Leu Ser Cys Ala Ala Thr Asp Ile Thr Tyr Ser Arg Cys Met 
145                 150                 155                 160 


Ala Trp Phe Arg Gln Ala Pro Gly Lys Ser Arg Glu Gly Val Ala Ala 
                165                 170                 175     


Leu Ser Thr Asn Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Asn Thr Ile Tyr Leu Gln 
        195                 200                 205             


Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Asp 
    210                 215                 220                 


Ser Ser Phe Phe Ser Cys Arg Asp Cys Ser Gly Gly Asp Cys Pro Arg 
225                 230                 235                 240 


Ser Arg Asp Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  90
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT22n7

<400>  90

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Thr Asp Ile Thr Tyr Ser Arg Cys 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Ser Arg Glu Gly Val Ala 
        35                  40                  45              


Ala Leu Ser Thr Asn Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Asp Ser Ser Phe Phe Ser Cys Arg Asp Cys Ser Gly Gly Asp Cys Pro 
            100                 105                 110         


Arg Ser Arg Asp Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser 
145                 150                 155                 160 


Ser Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Gly Val Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr 
    210                 215                 220                 


Cys Ala Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly 
225                 230                 235                 240 


Gly Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  91
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT7n42

<400>  91

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val Cys 
145                 150                 155                 160 


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                165                 170                 175     


Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly Phe 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250     


<210>  92
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT42n7

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr Cys Met Gly Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asp 
                165                 170                 175     


Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr Cys Ala Thr Glu Gln Arg 
    210                 215                 220                 


Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala Asp Phe Gly Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250     


<210>  93
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12n35

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Asp Asn Val Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly 
            100                 105                 110         


Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Tyr Thr Thr Thr Ser Arg 
145                 150                 155                 160 


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
                165                 170                 175     


Gly Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Gln Asp Thr Ala Lys Asn Thr Met Trp 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Phe Cys 
    210                 215                 220                 


Ala Ala Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Thr Arg Asp 
225                 230                 235                 240 


Val Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210>  94
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT35n12

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Tyr Thr Thr Thr Ser Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Gly Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Thr Ala Lys Asn Thr Met Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Thr Arg Asp 
            100                 105                 110         


Val Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr Cys Met 
145                 150                 155                 160 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Gly 
                165                 170                 175     


Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ser Ile Ser Lys Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Thr Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Ala Val Gln 
    210                 215                 220                 


Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly Ala Asp 
225                 230                 235                 240 


Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210>  95
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15n35

<400>  95

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln 
    130                 135                 140                 


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Tyr Thr Thr 
145                 150                 155                 160 


Thr Ser Arg Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Gly Val Gly Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala 
            180                 185                 190         


Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Gln Asp Thr Ala Lys Asn 
        195                 200                 205             


Thr Met Trp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met 
    210                 215                 220                 


Tyr Phe Cys Ala Ala Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu 
225                 230                 235                 240 


Thr Arg Asp Val Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  96
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15n42

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln 
    130                 135                 140                 


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr 
145                 150                 155                 160 


Ser Asp Val Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Gly Val Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr 
        195                 200                 205             


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His 
225                 230                 235                 240 


Glu Tyr Gly Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255 


<210>  97
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT35n42

<400>  97

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Tyr Thr Thr Thr Ser Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Gly Leu Ile Val Thr Gly Thr Gly Ala Thr Arg Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Thr Ala Lys Asn Thr Met Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ile Asp Ile Thr Trp Arg Gly Cys Ser Phe Glu Thr Arg Asp 
            100                 105                 110         


Val Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val Cys Met 
145                 150                 155                 160 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala 
                165                 170                 175     


Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Gln 
    210                 215                 220                 


Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly Phe Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250 


<210>  98
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12n15

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Asp Asn Val Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly 
            100                 105                 110         


Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
145                 150                 155                 160 


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
                165                 170                 175     


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
225                 230                 235                 240 


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  99
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT15n12

<400>  99

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly 
            100                 105                 110         


Leu Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln 
    130                 135                 140                 


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr 
145                 150                 155                 160 


Ser Ser Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Gly Val Ala Gly Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Val Lys Asn Thr 
        195                 200                 205             


Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Ile Tyr 
    210                 215                 220                 


Tyr Cys Ala Val Gln Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu 
225                 230                 235                 240 


Cys Gly Gly Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  100
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT12n42

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Glu Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Asp Asn Val Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ser Pro Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly 
            100                 105                 110         


Ala Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
145                 150                 155                 160 


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
                165                 170                 175     


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
225                 230                 235                 240 


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250         


<210>  101
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iPT42n12

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr Cys Met Gly Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Gly Ile Glu 
                165                 170                 175     


Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Ser 
            180                 185                 190         


Ile Ser Lys Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Ala Val Gln Ser Pro 
    210                 215                 220                 


Leu Pro Gly Gly Ser Trp Tyr Ser Leu Cys Gly Gly Ala Asp Phe Gly 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250         


<210>  102
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu7v11n15v7

<400>  102

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys 
145                 150                 155                 160 


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                165                 170                 175     


Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Lys Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu 
225                 230                 235                 240 


Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  103
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu7v11n15v11

<400>  103

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys 
145                 150                 155                 160 


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                165                 170                 175     


Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu 
225                 230                 235                 240 


Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  104
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu42v6n15v11-Fc

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys Met Ala Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Gly Val Asp 
                165                 170                 175     


Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Val Cys 
    210                 215                 220                 


Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu Phe Met Tyr 
225                 230                 235                 240 


Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255 


<210>  105
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu42v6n7v11

<400>  105

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr Cys Met Gly Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Asp 
                165                 170                 175     


Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Glu Gln Arg 
    210                 215                 220                 


Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala Asp Phe Gly Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  106
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu7v11n15v7-Fc

<400>  106

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys 
145                 150                 155                 160 


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                165                 170                 175     


Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Lys Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu 
225                 230                 235                 240 


Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490 


<210>  107
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu7v11n15v11-Fc

<400>  107

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gln Arg Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala 
            100                 105                 110         


Asp Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys 
145                 150                 155                 160 


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                165                 170                 175     


Gly Val Asp Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Gly Val Cys Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu 
225                 230                 235                 240 


Phe Met Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490 


<210>  108
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu42v6n15v11-Fc

<400>  108

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Gly Ser Tyr Cys Met Ala Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Gly Val Asp 
                165                 170                 175     


Ser Asp Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Val Cys 
    210                 215                 220                 


Gly Thr Gly Gly Ser Trp Tyr Glu Gly Asp Ala Gly Leu Phe Met Tyr 
225                 230                 235                 240 


Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu 
                245                 250                 255     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                325                 330                 335     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        435                 440                 445             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Pro Gly Lys 
                485         


<210>  109
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu42v6n7v11-Fc

<400>  109

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Asp Val 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Val Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Arg Cys Leu Gly Trp Val Pro Leu Val Pro His Glu Tyr Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr Cys Met Gly Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Asp 
                165                 170                 175     


Ser Asp Gly Arg Thr Ser Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Glu Gln Arg 
    210                 215                 220                 


Ile Gly Gly Ser Trp Tyr Asp Leu Cys Gly Gly Ala Asp Phe Gly Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


