                         SEQUENCE LISTING

<110>  The Walter and Eliza Hall Institute of Medical Research
 
<120>  Compositions and method for using same

<130>  529668PRV

<141>  2019-07-01

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine RIPK1 RHIM-interacting peptide

<400>  1

Tyr Thr Ile Phe Asn Ser Ser Gly Ile Gln Ile Gly Asn His Asn Tyr 
1               5                   10                  15      


Met 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine RIPK3 RHIM-interacting peptide

<400>  2

Leu Val Phe Asn Asn Cys Ser Glu Val Gln Ile Gly Asn Tyr Asn Ser 
1               5                   10                  15      


Leu 
    


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine DAI 1 RHIM-interacting peptide

<400>  3

Ile Ser Ile Ala Asn Ser Asn Ala Ile Gln Ile Gly His Gly Asn Val 
1               5                   10                  15      


Ile 
    


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine TRIF RHIM-interacting peptide

<400>  4

Leu Ile Ile His His Ala Gln Met Val Gln Leu Gly Val Asn Asn His 
1               5                   10                  15      


Met 
    


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine DAI 2 RHIM-interacting peptide

<400>  5

Met Asp Lys Ser Leu Leu Gln Gln Val Gln Leu Gly His His Asn Glu 
1               5                   10                  15      


Met 
    


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control RHIM-interacting peptide with alanine substitution

<400>  6

Leu Val Phe Asn Asn Cys Ser Glu Ala Ala Ala Ala Ala Tyr Ala Ser 
1               5                   10                  15      


Leu 
    


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT modified murine RIPK1 RHIM-interacting peptide

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Tyr Thr 
1               5                   10                  15      


Ile Phe Asn Ser Ser Gly Ile Gln Ile Gly Asn His Asn Tyr Met 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT modified murine RIPK3 RHIM-interacting peptide

<400>  8

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Leu Val 
1               5                   10                  15      


Phe Asn Asn Cys Ser Glu Val Gln Ile Gly Asn Tyr Asn Ser Leu 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT modified murine DAI 1 RHIM-interacting peptide

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Ile Ser 
1               5                   10                  15      


Ile Ala Asn Ser Asn Ala Ile Gln Ile Gly His Gly Asn Val Ile 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT modified murine RIF RHIM-interacting peptide

<400>  10

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Leu Ile 
1               5                   10                  15      


Ile His His Ala Gln Met Val Gln Leu Gly Val Asn Asn His Met 
            20                  25                  30      


<210>  11
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT modified murine DAI 2 RHIM-interacting peptide

<400>  11

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Met Asp 
1               5                   10                  15      


Lys Ser Leu Leu Gln Gln Val Gln Leu Gly His His Asn Glu Met 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control TAT modified RHIM-interacting peptide with alanine 
       substitution

<400>  12

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Leu Val 
1               5                   10                  15      


Phe Asn Asn Cys Ser Glu Ala Ala Ala Ala Ala Tyr Ala Ser Leu 
            20                  25                  30      


<210>  13
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding murine RIPK1 RHIM-interacting peptide

<400>  13
tatactattt tcaactcttc tggtattcaa attggtaacc acaactatat g                51


<210>  14
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Murine RIPK3 RHIM-interacting peptide

<400>  14
ttagttttca acaactgttc tgaagttcaa attggtaact ataactcttt a                51


<210>  15
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding murine DAI 1 RHIM-interacting peptide

<400>  15
atttctattg ctaactctaa cgctattcaa attggtcacg gtaacgttat t                51


<210>  16
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding murine TRIF RHIM-interacting peptide

<400>  16
ttaattattc accacgctca aatggttcaa ttaggtgtta acaaccacat g                51


<210>  17
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding murine RIPK1 RHIM-interacting peptide

<400>  17
uauacuauuu ucaacucuuc ugguauucaa auugguaacc acaacuauau g                51


<210>  18
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding murine RIPK3 RHIM-interacting peptide

<400>  18
uuaguuuuca acaacuguuc ugaaguucaa auugguaacu auaacucuuu a                51


<210>  19
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding murine DAI 1 RHIM-interacting peptide

<400>  19
auuucuauug cuaacucuaa cgcuauucaa auuggucacg guaacguuau u                51


<210>  20
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding murine TRIF RHIM-interacting peptide

<400>  20
uuaauuauuc accacgcuca aaugguucaa uuagguguua acaaccacau g                51


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human RIPK1 RHIM-interacting peptide

<400>  21

Tyr Thr Ile Tyr Asn Ser Thr Gly Ile Gln Ile Gly Ala Tyr Asn Tyr 
1               5                   10                  15      


Met 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human RIPK3 RHIM-interacting peptide

<400>  22

Val Asn Ile Tyr Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn Tyr 
1               5                   10                  15      


Leu 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DAI 1 RHIM-interacting peptide

<400>  23

Ile Ser Ile Ala Asn Ser Glu Ala Ile Gln Ile Gly His Gly Asn Ile 
1               5                   10                  15      


Ile 
    


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TRIF RHIM-interacting peptide

<400>  24

Leu Ile Ile His His Ala Gln Met Val Gln Leu Gly Leu Asn Asn His 
1               5                   10                  15      


Met 
    


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DAI 2 RHIM-interacting peptide

<400>  25

Met Glu Gln Ser Ile Leu Arg Arg Val Gln Leu Gly His Ser Asn Glu 
1               5                   10                  15      


Met 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DAI 3 RHIM-interacting peptide

<400>  26

Met Lys Ser Cys Phe Leu Glu Asp Ala Thr Ile Gly Asn Ser Asn Lys 
1               5                   10                  15      


Met 
    


<210>  27
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human RIPK1 RHIM-interacting peptide

<400>  27
tatactattt ataactctac tggtattcaa attggtgctt ataactatat g                51


<210>  28
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human RIPK3 RHIM-interacting peptide

<400>  28
gttaacattt ataactgttc tggtgttcaa gttggtgata acaactattt a                51


<210>  29
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human DAI 1 RHIM-interacting peptide

<400>  29
atttctattg ctaactctga agctattcaa attggtcacg gtaacattat t                51


<210>  30
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human TRIF RHIM-interacting peptide

<400>  30
ttaattattc accacgctca aatggttcaa ttaggtttaa acaaccacat g                51


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human DAI 2 RHIM-interacting peptide

<400>  31
atggaacaat ctattttacg tcgtgttcaa ttaggtcact ctaacgaaat g                51


<210>  32
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human DAI 3 RHIM-interacting peptide

<400>  32
atgaaatctt gtttcttaga agatgctact attggtaact ctaacaaaat g                51


<210>  33
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding human RIPK1 RHIM-interacting peptide

<400>  33
uauacuauuu auaacucuac ugguauucaa auuggugcuu auaacuauau g                51


<210>  34
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding human RIPK3 RHIM-interacting peptide

<400>  34
guuaacauuu auaacuguuc ugguguucaa guuggugaua acaacuauuu a                51


<210>  35
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding human DAI 1 RHIM-interacting peptide

<400>  35
auuucuauug cuaacucuga agcuauucaa auuggucacg guaacauuau u                51


<210>  36
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding human TRIF RHIM-interacting peptide

<400>  36
uuaauuauuc accacgcuca aaugguucaa uuagguuuaa acaaccacau g                51


<210>  37
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding human DAI 2 RHIM-interacting peptide

<400>  37
auggaacaau cuauuuuacg ucguguucaa uuaggucacu cuaacgaaau g                51


<210>  38
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA encoding human DAI 3 RHIM-interacting peptide

<400>  38
augaaaucuu guuucuuaga agaugcuacu auugguaacu cuaacaaaau g                51


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine RHIM consensus sequence

<400>  39

Thr Glu Ile Tyr Asn Ser Ser Gly Val Gln Ile Gly Asn Tyr Asn Tyr 
1               5                   10                  15      


Met 
    


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RIPK1 and RIPK3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Ile Gln Ile Gly Xaa Xaa Asn 
1               5           


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RHIM sequence mediating RHIM-RHIM binding


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid and can be present 
       or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is methionine or leucine

<400>  41

Xaa Xaa Ile Xaa Asn Xaa Xaa Xaa Xaa Xaa Gln Xaa Gly Xaa Xaa Asn 
1               5                   10                  15      


Xaa Xaa 
        


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RHIM sequence from human RIPK1

<400>  42

Ile Gln Ile Gly 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RHIM sequence from human RIPK3

<400>  43

Val Gln Val Gly 
1               


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core residues of motif in RHIM polypeptide able to form amyloid


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Xaa Gln Xaa Gly Xaa Xaa Asn 
1               5           


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  45

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  46

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  47

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  48

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  49
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  49

Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  50
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  50

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  51
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  51

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val Leu Cys Leu Arg Pro Val Gly 
            20                  25              


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  52

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  53
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  53

Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  54

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  55

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-penetrating peptide

<400>  56

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  57

Lys Arg Pro Arg Pro 
1               5   


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  58

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  59

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  60

Ser Ser Asp Asp Glu Ala Thr Ala Asp Ser Gln His Ala Ala Pro Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val 
            20          


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  61

Lys Lys Lys Arg Lys 
1               5   


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  62

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  63

Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys 
1               5                   10  


<210>  64
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  64

Val Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys 
1               5                   10                  15      


Asp Ala Lys Lys Ser Lys Gln Glu 
            20                  


<210>  65
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  65

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Cys Ala Lys Lys 
1               5                   10                  15      


Ser Lys Lys 
            


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  66

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  67

Arg Val His Pro Tyr Gln Arg 
1               5           


<210>  68
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  68

Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln Gln Leu Leu 
1               5                   10                  15      


Val Cys Ser Gln Glu Ala Lys Lys 
            20                  


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  69

Gly Lys Lys Arg Ser Lys Ala 
1               5           


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  70

Lys Ala Lys Arg Gln Arg 
1               5       


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  71

Arg Lys Arg Arg Arg 
1               5   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  72

Pro Pro Val Lys Arg Glu Arg Thr Ser 
1               5                   


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  73

Pro Tyr Leu Asn Lys Arg Lys Gly Lys Pro 
1               5                   10  


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  74

Lys Lys Lys Lys Arg Lys Arg Glu Lys 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  75

Lys Lys Lys Arg Arg Ser Arg Glu Lys 
1               5                   


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  76

Pro Arg Pro Arg Lys Ile Pro Arg 
1               5               


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  77

Lys Asp Cys Val Ile Asn Lys His His Arg Asn Arg Cys Gln Tyr Cys 
1               5                   10                  15      


Arg Leu Gln Arg 
            20  


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  78

Pro Arg Arg Arg Lys 
1               5   


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal peptide

<400>  79

Pro Gln Ser Arg Lys Lys Leu Arg 
1               5               


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subcellular localization signal peptide

<400>  80

Val Glu Arg Cys Phe Thr Asp 
1               5           


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subcellular localization signal peptide

<400>  81

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys 
1               5                   10          


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subcellular localization signal peptide

<400>  82

Met Leu Ile Ser Arg Cys Lys Trp Ser Arg Phe Pro Gly Asn Gln Arg 
1               5                   10                  15      


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subcellular localization signal peptide

<400>  83

Met Gln Arg Lys Pro Thr Ile Arg Arg Lys Asn Leu Arg Leu Arg Arg 
1               5                   10                  15      


Lys 
    


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subcellular localization signal peptide

<400>  84

Lys Gln Ala Trp Lys Gln Lys Trp Arg Lys Lys 
1               5                   10      


<210>  85
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trans-Activator of Transcription RIPK1 peptide

<400>  85

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Tyr Thr 
1               5                   10                  15      


Ile Phe Asn Ser Ser Gly Ile Gln Ile Gly Asn His Asn Tyr Met 
            20                  25                  30      


<210>  86
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trans-Activator of Transcription RIPK3 peptide

<400>  86

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Lys Leu Val 
1               5                   10                  15      


Phe Asn Asn Cys Ser Glu Val Gln Ile Gly Asn Tyr Asn Ser Leu 
            20                  25                  30      


<210>  87
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spans mmRIP1 RHIM, aa514-544 peptide

<400>  87

Ala Asp Asp Leu Ile Lys Tyr Thr Ile Phe Asn Ser Ser Gly Ile Gln 
1               5                   10                  15      


Ile Gly Asn His Asn Tyr Met Asp Val Gly Leu Asn Ser Gln Pro 
            20                  25                  30      


<210>  88
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant rRIP1 peptide

<400>  88

Ala Asp Asp Ser Ile Lys Tyr Thr His Phe Asp Ser Lys Gly Pro Gln 
1               5                   10                  15      


Ile Gly Asn His Asn Tyr Met Asp Val Gly Leu Asn Ser Gln Pro 
            20                  25                  30      


<210>  89
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spans mmRIP1 RHIM, aa435-458 peptide

<400>  89

Gly Pro Pro Ala Leu Val Phe Asn Asn Cys Ser Glu Val Gln Ile Gly 
1               5                   10                  15      


Asn Tyr Asn Ser Leu Val Ala 
            20              


<210>  90
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant rRIP3 peptide

<400>  90

Gly Pro Pro Ala Asp Val Phe Asp Asn Cys Ser Glu Pro Gln Ile Gly 
1               5                   10                  15      


Asn Tyr Asp Ser Leu Val Ala 
            20              


<210>  91
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rRIP3 with HIV-1 tat cell permeating peptide prefix peptide

<400>  91

Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Pro Pro Ala 
1               5                   10                  15      


Leu Val Phe Asn Asn Cys Ser Glu Val Gln Ile Gly Asn Tyr Asn Ser 
            20                  25                  30          


Leu Val Ala Pro Pro Arg Thr Thr Ala 
        35                  40      


<210>  92
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spans mmTRIF RHIM, aa 675-702 peptide

<400>  92

Gly Pro Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln Leu Gly 
1               5                   10                  15      


Val Asn Asn His Met Trp Gly His Thr Gly Ala 
            20                  25          


<210>  93
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spans mmDAI RHIM 1, aa 179-205 peptide

<400>  93

Ala Asn Ser His Ile Ser Ile Ala Asn Ser Asn Ala Ile Gln Ile Gly 
1               5                   10                  15      


His Gly Asn Val Ile Val Arg Glu Lys Ala 
            20                  25      


<210>  94
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spans  dsIMD RHIM,  aa 106-132 peptide

<400>  94

Gln Val Val Met Asn Phe Ser Asn Ala Asn Asn Leu His Phe Gly Ser 
1               5                   10                  15      


Val Tyr Asn Phe Asn Gln Asn Leu Ser Ala 
            20                  25      


<210>  95
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCMV M45  RHIM peptide

<400>  95

Val Pro Tyr Val Arg Ile Met Asn Gly Val Ser Gly Ile Gln Ile Gly 
1               5                   10                  15      


Asn His Asn Ala Met Ser Ile Ala 
            20                  


<210>  96
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human islet amyloid polypeptide

<400>  96

Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr 
        35  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bax BH3 domain, aa 59-73 peptide

<400>  97

Leu Ser Glu Cys Leu Lys Arg Ile Gly Asp Glu Leu Asp Ser Asn 
1               5                   10                  15  


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  98

Lys Trp Lys Leu Phe Lys Lys Ile Gly Ala Val Leu Lys Val Leu Thr 
1               5                   10                  15      


Thr Gly 
        


<210>  99
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  99

Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg 
1               5                   10                  15      


Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu 
            20                  25      


<210>  100
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  100

Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser 
1               5                   10                  15      


Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            20                  25      


<210>  101
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  101

Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr 
1               5                   10                  15      


Val Ile Ser His Arg Leu His Phe Pro Glu 
            20                  25      


<210>  102
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  102

Lys Lys Ala Leu Leu Ala Leu Ala Leu His His Leu Ala His Leu Ala 
1               5                   10                  15      


Leu His Leu Ala Leu Ala Leu Lys 
            20                  


<210>  103
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  103

Leu Leu Gly Arg Arg Gly Trp Glu Val Leu Lys Tyr Trp Trp Asn Leu 
1               5                   10                  15      


Leu Gln Tyr Trp Ser Gln Glu Leu 
            20                  


<210>  104
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  104

Gly Leu Phe His Ala Ile Ala His Phe Ile His Gly Gly Trp His Gly 
1               5                   10                  15      


Leu Ile His Gly Trp Tyr Gly 
            20              


<210>  105
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  105

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210>  106
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  106

Arg Leu Trp Ser His Leu Ile His Ile Trp Phe Gln Asn Arg Arg Leu 
1               5                   10                  15      


Lys Trp Lys Lys Lys 
            20      


<210>  107
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  107

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro 
            20                  25  


<210>  108
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  108

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala 
            20                  


<210>  109
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosome leakage domain peptide

<400>  109

Gly Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu 
1               5                   10                  15      


Leu Leu Glu Ala 
            20  


