                         SEQUENCE LISTING

<110>  Cellmid Limited
       Ludwig-Maximilians-Universitt Mnchen
       Ludwig-Maximilians-Universitt Mnchen, Medizinische Klinik
        und Poliklinik I
       Grabmaier, Ulrich
       WeckBach, Ludwig
       Walzog, Barbara
 
<120>  Methods of treating myocarditis and/or cardiomyopathy and 
       reagents therefor

<130>  187839PCT

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Lys Lys Asp Lys Val Lys Lys Gly Gly Pro Gly Ser Glu Cys Ala 
1               5                   10                  15      


Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser Ser Lys Asp Cys Gly Val 
            20                  25                  30          


Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln Thr Gln Arg Ile Arg Cys 
        35                  40                  45              


Arg Val Pro Cys Asn Trp Lys Lys Glu Phe Gly Ala Asp Cys Lys Tyr 
    50                  55                  60                  


Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly Gly Thr Gly Thr Lys Val 
65                  70                  75                  80  


Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr Asn Ala Gln Cys Gln Glu 
                85                  90                  95      


Thr Ile Arg Val Thr Lys Pro Cys Thr Pro Lys Thr Lys Ala Lys Ala 
            100                 105                 110         


Lys Ala Lys Lys Gly Lys Gly Lys Asp 
        115                 120     


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab1 Heavy chain variable region (version 1)

<400>  2

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro His Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Asn Asn Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly His Tyr Asp Glu Gly Tyr Phe Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab1 Light chain variable region

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Phe Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab1 VH CDR1

<400>  4

Thr Phe Thr Ser Tyr Trp Met His 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab1 VH CDR2

<400>  5

Ile Asn Pro His Asn Gly Gly Thr Asn 
1               5                   


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab1 VH CDR3

<400>  6

Gly Gly His Tyr Asp Glu Gly Tyr Phe Glu Tyr 
1               5                   10      


<210>  7
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab1 VL CDR1

<400>  7

Ile His Asn Tyr Leu Ala 
1               5       


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab1 VL CDR2

<400>  8

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab1 VL CDR3

<400>  9

Phe Trp Ser Thr Pro Phe Thr 
1               5           


<210>  10
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 Heavy chain variable region

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Gly Ser Ser Phe Asn Trp Leu Ala Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser 
        115                 120 


<210>  11
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 Light chain variable region

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Ala Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  12
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 VH CDR1

<400>  12

Ser Phe Thr Gly Tyr Phe Met Asn 
1               5               


<210>  13
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 VH CDR2

<400>  13

Ile Asn Pro Tyr Asn Gly Asp Thr Phe 
1               5                   


<210>  14
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 VH CDR3

<400>  14

Glu Ala Gly Gly Ser Ser Phe Asn Trp Leu Ala Tyr 
1               5                   10          


<210>  15
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 VL CDR1

<400>  15

Ile His Asn Phe Leu Ala 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 VL CDR2

<400>  16

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab2 VL CDR3

<400>  17

Phe Trp Ser Thr Pro Pro Thr 
1               5           


<210>  18
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab3 Heavy chain variable region

<400>  18

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Asn Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  19
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab3 Light chain variable region

<400>  19

Ser Ile Val Met Thr Gln Thr Pro Asn Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Leu Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MK-Ab3 VH CDR1

<400>  20

Thr Phe Thr Asp Tyr Asn Met Gly 
1               5               


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab3 VH CDR2

<400>  21

Ile Asn Pro Asn Asn Gly Gly Thr Ile 
1               5                   


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab3 VH CDR3

<400>  22

Trp Ser Tyr Ser Asn Pro Tyr Phe Asp Tyr 
1               5                   10  


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab3 VL CDR1

<400>  23

Val Ser Asn Asp Val Ser 
1               5       


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab3 VL CDR2

<400>  24

Tyr Ala Ser Asn Leu Tyr Thr 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab3 VL CDR3

<400>  25

Asp Tyr Ser Ser Pro Trp Thr 
1               5           


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab4 VH CDR1

<400>  26

Ser Phe Ser Ser Tyr Trp Met Asn 
1               5               


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab4 VH CDR2

<400>  27

Ile His Pro Ser Asp Ser Glu Thr Ile 
1               5                   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab4 VH CDR3

<400>  28

Trp Ser Ala Lys Arg Gly Asp Phe 
1               5               


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab4 VL CDR1

<400>  29

Ile Ser Asn Asn Leu His 
1               5       


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab4 VL CDR2

<400>  30

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab4 VL CDR3

<400>  31

Ser Asn Ser Trp Pro Leu Thr 
1               5           


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic cardiac peptide alpha-MyHC

<400>  32

Arg Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Thr Tyr Ala Ser Ala 
1               5                   10                  15      


Asp Arg 
        


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MK-Ab1 Heavy chain variable region (version 2)

<400>  33

Gln Val Lys Leu Glu Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro His Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Asn Asn Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly His Tyr Asp Glu Gly Tyr Phe Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


