                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  METHODS AND COMPOSITIONS FOR TREATING SMITH-MAGENIS SYNDROME

<130>  20378-202575

<150>  62/867,068
<151>  2019-06-26

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Thr Gln Arg Asp Ser Ser Thr Met Ser His Thr Val Ala Gly 
1               5                   10                  15      


Gly Gly Ser Gly Asp His Ser His Gln Val Arg Val Lys Ala Tyr Tyr 
            20                  25                  30          


Arg Gly Asp Ile Met Ile Thr His Phe Glu Pro Ser Ile Ser Phe Glu 
        35                  40                  45              


Gly Leu Cys Asn Glu Val Arg Asp Met Cys Ser Phe Asp Asn Glu Gln 
    50                  55                  60                  


Leu Phe Thr Met Lys Trp Ile Asp Glu Glu Gly Asp Pro Cys Thr Val 
65                  70                  75                  80  


Ser Ser Gln Leu Glu Leu Glu Glu Ala Phe Arg Leu Tyr Glu Leu Asn 
                85                  90                  95      


Lys Asp Ser Glu Leu Leu Ile His Val Phe Pro Cys Val Pro Glu Arg 
            100                 105                 110         


Pro Gly Met Pro Cys Pro Gly Glu Asp Lys Ser Ile Tyr Arg Arg Gly 
        115                 120                 125             


Ala Arg Arg Trp Arg Lys Leu Tyr Cys Ala Asn Gly His Thr Phe Gln 
    130                 135                 140                 


Ala Lys Arg Phe Asn Arg Arg Ala His Cys Ala Ile Cys Thr Asp Arg 
145                 150                 155                 160 


Ile Trp Gly Leu Gly Arg Gln Gly Tyr Lys Cys Ile Asn Cys Lys Leu 
                165                 170                 175     


Leu Val His Lys Lys Cys His Lys Leu Val Thr Ile Glu Cys Gly Arg 
            180                 185                 190         


His Ser Leu Pro Gln Glu Pro Val Met Pro Met Asp Gln Ser Ser Met 
        195                 200                 205             


His Ser Asp His Ala Gln Thr Val Ile Pro Tyr Asn Pro Ser Ser His 
    210                 215                 220                 


Glu Ser Leu Asp Gln Val Gly Glu Glu Lys Glu Ala Met Asn Thr Arg 
225                 230                 235                 240 


Glu Ser Gly Lys Ala Ser Ser Ser Leu Gly Leu Gln Asp Phe Asp Leu 
                245                 250                 255     


Leu Arg Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg 
            260                 265                 270         


Leu Lys Lys Thr Asp Arg Ile Tyr Ala Met Lys Val Val Lys Lys Glu 
        275                 280                 285             


Leu Val Asn Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His 
    290                 295                 300                 


Val Phe Glu Gln Ala Ser Asn His Pro Phe Leu Val Gly Leu His Ser 
305                 310                 315                 320 


Cys Phe Gln Thr Glu Ser Arg Leu Phe Phe Val Ile Glu Tyr Val Asn 
                325                 330                 335     


Gly Gly Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu 
            340                 345                 350         


Glu His Ala Arg Phe Tyr Ser Ala Glu Ile Ser Leu Ala Leu Asn Tyr 
        355                 360                 365             


Leu His Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val 
    370                 375                 380                 


Leu Leu Asp Ser Glu Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys 
385                 390                 395                 400 


Lys Glu Gly Leu Arg Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr 
                405                 410                 415     


Pro Asn Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Asp Tyr Gly Phe 
            420                 425                 430         


Ser Val Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala 
        435                 440                 445             


Gly Arg Ser Pro Phe Asp Ile Val Gly Ser Ser Asp Asn Pro Asp Gln 
    450                 455                 460                 


Asn Thr Glu Asp Tyr Leu Phe Gln Val Ile Leu Glu Lys Gln Ile Arg 
465                 470                 475                 480 


Ile Pro Arg Ser Leu Ser Val Lys Ala Ala Ser Val Leu Lys Ser Phe 
                485                 490                 495     


Leu Asn Lys Asp Pro Lys Glu Arg Leu Gly Cys His Pro Gln Thr Gly 
            500                 505                 510         


Phe Ala Asp Ile Gln Gly His Pro Phe Phe Arg Asn Val Asp Trp Asp 
        515                 520                 525             


Met Met Glu Gln Lys Gln Val Val Pro Pro Phe Lys Pro Asn Ile Ser 
    530                 535                 540                 


Gly Glu Phe Gly Leu Asp Asn Phe Asp Ser Gln Phe Thr Asn Glu Pro 
545                 550                 555                 560 


Val Gln Leu Thr Pro Asp Asp Asp Asp Ile Val Arg Lys Ile Asp Gln 
                565                 570                 575     


Ser Glu Phe Glu Gly Phe Glu Tyr Ile Asn Pro Leu Leu Met Ser Ala 
            580                 585                 590         


Glu Glu Cys Val 
        595     


<210>  2
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ser Arg Thr Gly Pro Lys Met Glu Gly Ser Gly Gly Arg Val 
1               5                   10                  15      


Arg Leu Lys Ala His Tyr Gly Gly Asp Ile Phe Ile Thr Ser Val Asp 
            20                  25                  30          


Ala Ala Thr Thr Phe Glu Glu Leu Cys Glu Glu Val Arg Asp Met Cys 
        35                  40                  45              


Arg Leu His Gln Gln His Pro Leu Thr Leu Lys Trp Val Asp Ser Glu 
    50                  55                  60                  


Gly Asp Pro Cys Thr Val Ser Ser Gln Met Glu Leu Glu Glu Ala Phe 
65                  70                  75                  80  


Arg Leu Ala Arg Gln Cys Arg Asp Glu Gly Leu Ile Ile His Val Phe 
                85                  90                  95      


Pro Ser Thr Pro Glu Gln Pro Gly Leu Pro Cys Pro Gly Glu Asp Lys 
            100                 105                 110         


Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Arg Ala 
        115                 120                 125             


Asn Gly His Leu Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala Tyr Cys 
    130                 135                 140                 


Gly Gln Cys Ser Glu Arg Ile Trp Gly Leu Ala Arg Gln Gly Tyr Arg 
145                 150                 155                 160 


Cys Ile Asn Cys Lys Leu Leu Val His Lys Arg Cys His Gly Leu Val 
                165                 170                 175     


Pro Leu Thr Cys Arg Lys His Met Asp Ser Val Met Pro Ser Gln Glu 
            180                 185                 190         


Pro Pro Val Asp Asp Lys Asn Glu Asp Ala Asp Leu Pro Ser Glu Glu 
        195                 200                 205             


Thr Asp Gly Ile Ala Tyr Ile Ser Ser Ser Arg Lys His Asp Ser Ile 
    210                 215                 220                 


Lys Asp Asp Ser Glu Asp Leu Lys Pro Val Ile Asp Gly Met Asp Gly 
225                 230                 235                 240 


Ile Lys Ile Ser Gln Gly Leu Gly Leu Gln Asp Phe Asp Leu Ile Arg 
                245                 250                 255     


Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg Leu Lys 
            260                 265                 270         


Lys Asn Asp Gln Ile Tyr Ala Met Lys Val Val Lys Lys Glu Leu Val 
        275                 280                 285             


His Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His Val Phe 
    290                 295                 300                 


Glu Gln Ala Ser Ser Asn Pro Phe Leu Val Gly Leu His Ser Cys Phe 
305                 310                 315                 320 


Gln Thr Thr Ser Arg Leu Phe Leu Val Ile Glu Tyr Val Asn Gly Gly 
                325                 330                 335     


Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu Glu His 
            340                 345                 350         


Ala Arg Phe Tyr Ala Ala Glu Ile Cys Ile Ala Leu Asn Phe Leu His 
        355                 360                 365             


Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu 
    370                 375                 380                 


Asp Ala Asp Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys Lys Glu 
385                 390                 395                 400 


Gly Leu Gly Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr Pro Asn 
                405                 410                 415     


Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Glu Tyr Gly Phe Ser Val 
            420                 425                 430         


Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala Gly Arg 
        435                 440                 445             


Ser Pro Phe Asp Ile Ile Thr Asp Asn Pro Asp Met Asn Thr Glu Asp 
    450                 455                 460                 


Tyr Leu Phe Gln Val Ile Leu Glu Lys Pro Ile Arg Ile Pro Arg Phe 
465                 470                 475                 480 


Leu Ser Val Lys Ala Ser His Val Leu Lys Gly Phe Leu Asn Lys Asp 
                485                 490                 495     


Pro Lys Glu Arg Leu Gly Cys Arg Pro Gln Thr Gly Phe Ser Asp Ile 
            500                 505                 510         


Lys Ser His Ala Phe Phe Arg Ser Ile Asp Trp Asp Leu Leu Glu Lys 
        515                 520                 525             


Lys Gln Ala Leu Pro Pro Phe Gln Pro Gln Ile Thr Asp Asp Tyr Gly 
    530                 535                 540                 


Leu Asp Asn Phe Asp Thr Gln Phe Thr Ser Glu Pro Val Gln Leu Thr 
545                 550                 555                 560 


Pro Asp Asp Glu Asp Ala Ile Lys Arg Ile Asp Gln Ser Glu Phe Glu 
                565                 570                 575     


Gly Phe Glu Tyr Ile Asn Pro Leu Leu Leu Ser Thr Glu Glu Ser Val 
            580                 585                 590         


<210>  3
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ser Val Met Pro Ser Gln Glu Pro Pro Val Asp Asp Lys Asn 
1               5                   10                  15      


Glu Asp Ala Asp Leu Pro Ser Glu Glu Thr Asp Gly Ile Ala Tyr Ile 
            20                  25                  30          


Ser Ser Ser Arg Lys His Asp Ser Ile Lys Asp Asp Ser Glu Asp Leu 
        35                  40                  45              


Lys Pro Val Ile Asp Gly Met Asp Gly Ile Lys Ile Ser Gln Gly Leu 
    50                  55                  60                  


Gly Leu Gln Asp Phe Asp Leu Ile Arg Val Ile Gly Arg Gly Ser Tyr 
65                  70                  75                  80  


Ala Lys Val Leu Leu Val Arg Leu Lys Lys Asn Asp Gln Ile Tyr Ala 
                85                  90                  95      


Met Lys Val Val Lys Lys Glu Leu Val His Asp Asp Glu Asp Ile Asp 
            100                 105                 110         


Trp Val Gln Thr Glu Lys His Val Phe Glu Gln Ala Ser Ser Asn Pro 
        115                 120                 125             


Phe Leu Val Gly Leu His Ser Cys Phe Gln Thr Thr Ser Arg Leu Phe 
    130                 135                 140                 


Leu Val Ile Glu Tyr Val Asn Gly Gly Asp Leu Met Phe His Met Gln 
145                 150                 155                 160 


Arg Gln Arg Lys Leu Pro Glu Glu His Ala Arg Phe Tyr Ala Ala Glu 
                165                 170                 175     


Ile Cys Ile Ala Leu Asn Phe Leu His Glu Arg Gly Ile Ile Tyr Arg 
            180                 185                 190         


Asp Leu Lys Leu Asp Asn Val Leu Leu Asp Ala Asp Gly His Ile Lys 
        195                 200                 205             


Leu Thr Asp Tyr Gly Met Cys Lys Glu Gly Leu Gly Pro Gly Asp Thr 
    210                 215                 220                 


Thr Ser Thr Phe Cys Gly Thr Pro Asn Tyr Ile Ala Pro Glu Ile Leu 
225                 230                 235                 240 


Arg Gly Glu Glu Tyr Gly Phe Ser Val Asp Trp Trp Ala Leu Gly Val 
                245                 250                 255     


Leu Met Phe Glu Met Met Ala Gly Arg Ser Pro Phe Asp Ile Ile Thr 
            260                 265                 270         


Asp Asn Pro Asp Met Asn Thr Glu Asp Tyr Leu Phe Gln Val Ile Leu 
        275                 280                 285             


Glu Lys Pro Ile Arg Ile Pro Arg Phe Leu Ser Val Lys Ala Ser His 
    290                 295                 300                 


Val Leu Lys Gly Phe Leu Asn Lys Asp Pro Lys Glu Arg Leu Gly Cys 
305                 310                 315                 320 


Arg Pro Gln Thr Gly Phe Ser Asp Ile Lys Ser His Ala Phe Phe Arg 
                325                 330                 335     


Ser Ile Asp Trp Asp Leu Leu Glu Lys Lys Gln Ala Leu Pro Pro Phe 
            340                 345                 350         


Gln Pro Gln Ile Thr Asp Asp Tyr Gly Leu Asp Asn Phe Asp Thr Gln 
        355                 360                 365             


Phe Thr Ser Glu Pro Val Gln Leu Thr Pro Asp Asp Glu Asp Ala Ile 
    370                 375                 380                 


Lys Arg Ile Asp Gln Ser Glu Phe Glu Gly Phe Glu Tyr Ile Asn Pro 
385                 390                 395                 400 


Leu Leu Leu Ser Thr Glu Glu Ser Val 
                405                 


<210>  4
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Val Gln Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr 
65                  70                  75                  80  


Gly Thr Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser 
                85                  90                  95      


Lys Asp Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly 
            100                 105                 110         


Leu Thr Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile 
        115                 120                 125             


Ala Phe Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro 
    130                 135                 140                 


Cys Gly Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg 
                165                 170                 175     


Ala Asp Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu 
            180                 185                 190         


Ile Phe Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile 
        195                 200                 205             


Leu Asp Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val 
    210                 215                 220                 


Ser Leu Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu 
225                 230                 235                 240 


Leu Glu Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg 
                245                 250                 255     


Ser Thr Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile 
            260                 265                 270         


Gln Arg Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr 
        275                 280                 285             


Ile Tyr Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys 
    290                 295                 300                 


His Met Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn 
305                 310                 315                 320 


Ala Thr Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg 
                325                 330                 335     


Asp Ser Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg 
            340                 345                 350         


Arg Val Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala 
        355                 360                 365             


Phe Ile His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro 
    370                 375                 380                 


Gly Glu Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser 
385                 390                 395                 400 


Met Ala Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn 
                405                 410                 415     


Tyr His Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr 
            420                 425                 430         


Asn Gly Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly 
        435                 440                 445             


Pro Thr Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg 
    450                 455                 460                 


Leu Val Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val 
465                 470                 475                 480 


Phe Val Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys 
                485                 490                 495     


Ile Pro Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His 
            500                 505                 510         


Lys Phe Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520                 


<210>  5
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Thr Glu Ser Gln Tyr Ser Gly Tyr Ser Tyr Lys Ser Gly His 
1               5                   10                  15      


Ser Arg Ser Ser Arg Lys His Arg Asp Arg Arg Asp Arg His Arg Ser 
            20                  25                  30          


Lys Ser Arg Asp Gly Gly Arg Gly Asp Lys Ser Val Thr Ile Gln Ala 
        35                  40                  45              


Pro Gly Glu Pro Leu Leu Asp Asn Glu Ser Thr Arg Gly Asp Glu Arg 
    50                  55                  60                  


Asp Asp Asn Trp Gly Glu Thr Thr Thr Val Val Thr Gly Thr Ser Glu 
65                  70                  75                  80  


His Ser Ile Ser His Asp Asp Leu Thr Arg Ile Ala Lys Asp Met Glu 
                85                  90                  95      


Asp Ser Val Pro Leu Asp Cys Ser Arg His Leu Gly Val Ala Ala Gly 
            100                 105                 110         


Ala Thr Leu Ala Leu Leu Ser Phe Leu Thr Pro Leu Ala Phe Leu Leu 
        115                 120                 125             


Leu Pro Pro Leu Leu Trp Arg Glu Glu Leu Glu Pro Cys Gly Thr Ala 
    130                 135                 140                 


Cys Glu Gly Leu Phe Ile Ser Val Ala Phe Lys Leu Leu Ile Leu Leu 
145                 150                 155                 160 


Leu Gly Ser Trp Ala Leu Phe Phe Arg Arg Pro Lys Ala Ser Leu Pro 
                165                 170                 175     


Arg Val Phe Val Leu Arg Ala Leu Leu Met Val Leu Val Phe Leu Leu 
            180                 185                 190         


Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp Ala Arg 
        195                 200                 205             


Glu Arg Ser Tyr Gln Gly Val Val Gln Phe Ala Val Ser Leu Val Asp 
    210                 215                 220                 


Ala Leu Leu Phe Val His Tyr Leu Ala Val Val Leu Leu Glu Leu Arg 
225                 230                 235                 240 


Gln Leu Gln Pro Gln Phe Thr Leu Lys Val Val Arg Ser Thr Asp Gly 
                245                 250                 255     


Ala Ser Arg Phe Tyr Asn Val Gly His Leu Ser Ile Gln Arg Val Ala 
            260                 265                 270         


Val Trp Ile Leu Glu Lys Tyr Tyr His Asp Phe Pro Val Tyr Asn Pro 
        275                 280                 285             


Ala Leu Leu Asn Leu Pro Lys Ser Val Leu Ala Lys Lys Val Ser Gly 
    290                 295                 300                 


Phe Lys Val Tyr Ser Leu Gly Glu Glu Asn Ser Thr Asn Asn Ser Thr 
305                 310                 315                 320 


Gly Gln Ser Arg Ala Val Ile Ala Ala Ala Ala Arg Arg Arg Asp Asn 
                325                 330                 335     


Ser His Asn Glu Tyr Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg Val 
            340                 345                 350         


Arg Lys Arg Arg Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe Thr 
        355                 360                 365             


His Ile Lys Arg Leu Gln Glu Glu Glu Gln Lys Asn Pro Arg Glu Val 
    370                 375                 380                 


Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Ala Ser Met Ala Arg 
385                 390                 395                 400 


Ala Met Gln Lys Tyr Leu Arg Thr Thr Lys Gln Gln Pro Tyr His Thr 
                405                 410                 415     


Met Glu Ser Ile Leu Gln His Leu Glu Phe Cys Ile Thr His Asp Met 
            420                 425                 430         


Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ala Ala Gly Pro Thr Ile 
        435                 440                 445             


Gln Tyr His Lys Glu Arg Trp Leu Ala Lys Gln Trp Thr Leu Val Ser 
    450                 455                 460                 


Glu Glu Pro Val Thr Asn Gly Leu Lys Asp Gly Ile Val Phe Leu Leu 
465                 470                 475                 480 


Lys Arg Gln Asp Phe Ser Leu Val Val Ser Thr Lys Lys Val Pro Phe 
                485                 490                 495     


Phe Lys Leu Ser Glu Glu Phe Val Asp Pro Lys Ser His Lys Phe Val 
            500                 505                 510         


Met Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520     


<210>  6
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Met Lys Phe Arg Phe Arg Arg Gln Gly Ala Asp Pro Gln Arg Glu 
1               5                   10                  15      


Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu His Gly 
            20                  25                  30          


Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu Arg Ile 
        35                  40                  45              


Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Ile Tyr Gly Ala Pro 
    50                  55                  60                  


Gly Val Glu Phe Thr Gly Leu His Arg Asp Ala Ala Thr Val Thr Gln 
65                  70                  75                  80  


Met His Phe Leu Thr Gly Gln Gly Arg Leu Leu Ser Leu Leu Asp Asp 
                85                  90                  95      


Ser Ser Leu His Leu Trp Glu Ile Val His His Asn Gly Cys Ala His 
            100                 105                 110         


Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro Ser Arg Pro Gly Phe Asp 
        115                 120                 125             


Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg Val Thr Val Val Leu Leu 
    130                 135                 140                 


Val Ala Ala Ser Asp Ile Ala Ala Leu Gly Thr Glu Gly Ser Ser Val 
145                 150                 155                 160 


Phe Phe Leu Asp Val Thr Thr Leu Thr Leu Leu Glu Gly Gln Thr Leu 
                165                 170                 175     


Ala Pro Gly Glu Val Leu Arg Ser Val Pro Asp Asp Tyr Arg Cys Gly 
            180                 185                 190         


Lys Ala Leu Gly Pro Val Glu Ser Leu Gln Gly His Leu Arg Asp Pro 
        195                 200                 205             


Thr Lys Ile Leu Ile Gly Tyr Ser Arg Gly Leu Leu Val Ile Trp Asn 
    210                 215                 220                 


Gln Ala Ser Gln Cys Val Asp His Ile Phe Leu Gly Asn Gln Gln Leu 
225                 230                 235                 240 


Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser Thr Val Val Ser Ser His 
                245                 250                 255     


Ser Asp Gly Ser Tyr Ala Val Trp Ser Val Asp Ala Gly Ser Phe Pro 
            260                 265                 270         


Thr Leu Gln Pro Thr Val Ala Thr Thr Pro Tyr Gly Pro Phe Pro Cys 
        275                 280                 285             


Lys Ala Ile Asn Lys Ile Leu Trp Arg Asn Cys Glu Ser Gly Gly His 
    290                 295                 300                 


Phe Ile Ile Phe Ser Gly Gly Met Pro Arg Ala Ser Tyr Gly Asp Arg 
305                 310                 315                 320 


His Cys Val Ser Val Leu Arg Ala Glu Thr Leu Val Thr Leu Asp Phe 
                325                 330                 335     


Thr Ser Arg Ile Ile Asp Phe Phe Thr Val His Ser Thr Arg Pro Glu 
            340                 345                 350         


Asp Glu Phe Asp Asp Pro Gln Ala Leu Ala Val Leu Leu Glu Glu Glu 
        355                 360                 365             


Leu Val Val Leu Asp Leu Gln Thr Pro Gly Trp Pro Ala Val Pro Ala 
    370                 375                 380                 


Pro Tyr Leu Ala Pro Leu His Ser Ser Ala Ile Thr Cys Ser Ala His 
385                 390                 395                 400 


Val Ala Ser Val Pro Ala Lys Leu Trp Ala Arg Ile Val Ser Ala Gly 
                405                 410                 415     


Glu Gln Gln Ser Pro Gln Pro Val Ser Ser Ala Leu Ser Trp Pro Ile 
            420                 425                 430         


Thr Gly Gly Arg Asn Leu Ala Gln Glu Pro Ser Gln Arg Gly Leu Leu 
        435                 440                 445             


Leu Thr Gly His Glu Asp Gly Thr Val Arg Phe Trp Asp Ala Ser Gly 
    450                 455                 460                 


Val Ala Leu Arg Pro Leu Tyr Lys Leu Ser Thr Ala Gly Leu Phe Gln 
465                 470                 475                 480 


Thr Asp Cys Glu His Ala Asp Ser Leu Ala Gln Ala Ala Glu Asp Asp 
                485                 490                 495     


Trp Pro Pro Phe Arg Lys Val Gly Cys Phe Asp Pro Tyr Ser Asp Asp 
            500                 505                 510         


Pro Arg Leu Gly Val Gln Lys Val Ala Leu Cys Lys Tyr Thr Ala Gln 
        515                 520                 525             


Met Val Val Ala Gly Thr Ala Gly Gln Val Leu Val Leu Glu Leu Ser 
    530                 535                 540                 


Asp Val Pro Val Glu Gln Ala Val Ser Val Ala Ile Ile Asp Leu Leu 
545                 550                 555                 560 


Gln Asp Arg Glu Gly Phe Thr Trp Lys Gly His Glu Arg Leu Ser Pro 
                565                 570                 575     


Arg Thr Gly Pro Leu Pro Trp Pro Ala Gly Phe Gln Pro Arg Val Leu 
            580                 585                 590         


Val Gln Cys Leu Pro Pro Ala Ala Val Thr Ala Val Thr Leu His Thr 
        595                 600                 605             


Glu Trp Ser Leu Val Ala Phe Gly Thr Ser His Gly Phe Gly Leu Phe 
    610                 615                 620                 


Asp Tyr Gln Arg Lys Ser Pro Val Leu Ala Arg Cys Thr Leu His Pro 
625                 630                 635                 640 


Asn Asp Ser Leu Ala Met Glu Gly Pro Leu Ser Arg Val Lys Ser Leu 
                645                 650                 655     


Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg Ile Arg Lys Ser Arg Val 
            660                 665                 670         


Ser Gly Lys Lys Arg Ala Ala Asn Ala Ser Ser Lys Leu Gln Glu Ala 
        675                 680                 685             


Asn Ala Gln Leu Ala Glu Gln Ala Cys Pro His Asp Val Glu Met Thr 
    690                 695                 700                 


Pro Val Gln Arg Arg Ile Glu Pro Arg Ser Ala Asp Asp Ser Leu Ser 
705                 710                 715                 720 


Gly Val Val Arg Cys Leu Tyr Phe Ala Asp Thr Phe Leu Arg Asp Gly 
                725                 730                 735     


Ala His His Gly Pro Thr Met Trp Ala Gly Thr Asn Ser Gly Ser Val 
            740                 745                 750         


Phe Ala Tyr Ala Leu Glu Val Pro Ala Ala Ala Val Gly Gly Glu Lys 
        755                 760                 765             


Arg Pro Glu Gln Ala Val Glu Ala Val Leu Gly Lys Glu Val Gln Leu 
    770                 775                 780                 


Met His Arg Ala Pro Val Val Ala Ile Ala Val Leu Asp Gly Arg Gly 
785                 790                 795                 800 


Arg Pro Leu Pro Glu Pro Tyr Glu Ala Ser Arg Asp Leu Ala Gln Ala 
                805                 810                 815     


Pro Asp Met Gln Gly Gly His Ala Val Leu Ile Ala Ser Glu Glu Gln 
            820                 825                 830         


Phe Lys Val Phe Thr Leu Pro Lys Val Ser Ala Lys Thr Lys Phe Lys 
        835                 840                 845             


Leu Thr Ala His Glu Gly Cys Arg Val Arg Lys Val Ala Leu Ala Thr 
    850                 855                 860                 


Phe Ala Ser Val Ala Cys Glu Asp Tyr Ala Glu Thr Cys Leu Ala Cys 
865                 870                 875                 880 


Leu Thr Asn Leu Gly Asp Val His Val Phe Ser Val Pro Gly Leu Arg 
                885                 890                 895     


Pro Gln Val His Tyr Ser Cys Ile Arg Lys Glu Asp Ile Ser Gly Ile 
            900                 905                 910         


Ala Ser Cys Val Phe Thr Arg His Gly Gln Gly Phe Tyr Leu Ile Ser 
        915                 920                 925             


Pro Ser Glu Phe Glu Arg Phe Ser Leu Ser Ala Arg Asn Ile Thr Glu 
    930                 935                 940                 


Pro Leu Cys Ser Leu Asp Ile Asn Trp Pro Arg Asp Ala Thr Gln Ala 
945                 950                 955                 960 


Ser Tyr Arg Ile Arg Glu Ser Pro Lys Leu Ser Gln Ala Asn Gly Thr 
                965                 970                 975     


Pro Ser Ile Leu Leu Ala Pro Gln Ser Leu Asp Gly Ser Pro Asp Pro 
            980                 985                 990         


Ala His Ser Met Gly Pro Asp Thr  Pro Glu Pro Pro Glu  Ala Ala Leu 
        995                 1000                 1005             


Ser Pro  Met Ser Ile Asp Ser  Ala Thr Ser Ala Asp  Thr Thr Leu 
    1010                 1015                 1020             


Asp Thr  Thr Gly Asp Val Thr  Val Glu Asp Val Lys  Asp Phe Leu 
    1025                 1030                 1035             


Gly Ser  Ser Glu Glu Ser Glu  Lys Asn Leu Arg Asn  Leu Ala Glu 
    1040                 1045                 1050             


Asp Glu  Ala His Ala Cys Ala  Ile Leu Ile Lys 
    1055                 1060                 


<210>  7
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Val Arg Lys Gln Asp Thr Gln Arg Ala Leu His Leu Leu Glu 
1               5                   10                  15      


Glu Tyr Arg Ser Lys Leu Ser Gln Thr Glu Asp Arg Gln Leu Arg Ser 
            20                  25                  30          


Ser Ile Glu Arg Val Ile Asn Ile Phe Gln Ser Asn Leu Phe Gln Ala 
        35                  40                  45              


Leu Ile Asp Ile Gln Glu Phe Tyr Glu Val Thr Leu Leu Asp Asn Pro 
    50                  55                  60                  


Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile Gln Pro Val Asn 
65                  70                  75                  80  


Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val Thr Ser Glu Thr 
                85                  90                  95      


Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr Arg Tyr Gln Asp 
            100                 105                 110         


Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln Ile Thr Asn Glu 
        115                 120                 125             


Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys Asn Leu Ser Glu 
    130                 135                 140                 


Ile Glu Asn Val His Gly Phe Val Ser His Ser His Ile Ser Pro Ile 
145                 150                 155                 160 


Lys Pro Thr Glu Ala Val Leu Pro Ser Pro Pro Thr Val Pro Val Ile 
                165                 170                 175     


Pro Val Leu Pro Val Pro Ala Glu Asn Thr Val Ile Leu Pro Thr Ile 
            180                 185                 190         


Pro Gln Ala Asn Pro Pro Pro Val Leu Val Asn Thr Asp Ser Leu Glu 
        195                 200                 205             


Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr Glu Tyr Glu Glu 
    210                 215                 220                 


Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly 
225                 230                 235                 240 


Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile Phe Ile Thr 
                245                 250                 255     


Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val 
            260                 265                 270         


Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg Asp Val Thr 
        275                 280                 285             


His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg 
    290                 295                 300                 


Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile Met Glu Ile 
305                 310                 315                 320 


Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly 
                325                 330                 335     


Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys 
            340                 345                 350         


Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu Gln Ile Gly 
        355                 360                 365             


Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu Val Thr His 
    370                 375                 380                 


Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe Val Tyr Leu 
385                 390                 395                 400 


Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly Tyr Ala Pro 
                405                 410                 415     


Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn His Val Ser 
            420                 425                 430         


Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala Arg Tyr Ser 
        435                 440                 445             


Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr Arg Glu Pro 
    450                 455                 460                 


Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly Phe Asn Ile 
465                 470                 475                 480 


Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu Ala 
                485                 490                 495     


Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Arg Ile 
            500                 505                 510         


Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His Glu Gln Ala 
        515                 520                 525             


Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile Val Ala Gln 
    530                 535                 540                 


Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His Asp Leu 
545                 550                 555                 560 


Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser Gly Ser Leu 
                565                 570                 575     


Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp Tyr 
            580                 585                 590         


Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu Asn Phe Lys 
        595                 600                 605             


Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp 
    610                 615                 620                 


Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu Val Gly Val 
625                 630                 635                 640 


Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala Arg Leu Lys 
                645                 650                 655     


Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Glu Ile Pro Asp 
            660                 665                 670         


Asp Met Gly Ser Lys Gly Leu Lys His Val Thr Ser Asn Ala Ser Asp 
        675                 680                 685             


Ser Glu Ser Ser Tyr Arg Gly Gln Glu Glu Tyr Val Leu Ser Tyr Glu 
    690                 695                 700                 


Pro Val Asn Gln Gln Glu Val Asn Tyr Thr Arg Pro Val Ile Ile Leu 
705                 710                 715                 720 


Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser Glu Phe Pro 
                725                 730                 735     


Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Asp 
            740                 745                 750         


Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val Thr Ser Arg Glu Gln 
        755                 760                 765             


Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala Gly Gln Tyr 
    770                 775                 780                 


Asn Asn His Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala 
785                 790                 795                 800 


Glu Lys Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn Ala Ile Lys 
                805                 810                 815     


Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile Ser Ile Phe Ile Lys Pro 
            820                 825                 830         


Lys Ser Met Glu Asn Ile Met Glu Met Asn Lys Arg Leu Thr Glu Glu 
        835                 840                 845             


Gln Ala Arg Lys Thr Phe Glu Arg Ala Met Lys Leu Glu Gln Glu Phe 
    850                 855                 860                 


Thr Glu His Phe Thr Ala Ile Val Gln Gly Asp Thr Leu Glu Asp Ile 
865                 870                 875                 880 


Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu Gln Ser Gly Ser Tyr Ile 
                885                 890                 895     


Trp Val Pro Ala Lys Glu Lys Leu 
            900                 


<210>  8
<211>  817
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His Lys His Gln His Cys Cys Lys Cys Pro Glu Cys Tyr Glu Val 
1               5                   10                  15      


Thr Arg Leu Ala Ala Leu Arg Arg Leu Glu Pro Pro Gly Tyr Gly Asp 
            20                  25                  30          


Trp Gln Val Pro Asp Pro Tyr Gly Pro Gly Gly Gly Asn Gly Ala Ser 
        35                  40                  45              


Ala Gly Tyr Gly Gly Tyr Ser Ser Gln Thr Leu Pro Ser Gln Ala Gly 
    50                  55                  60                  


Ala Thr Pro Thr Pro Arg Thr Lys Ala Lys Leu Ile Pro Thr Gly Arg 
65                  70                  75                  80  


Asp Val Gly Pro Val Pro Pro Lys Pro Val Pro Gly Lys Ser Thr Pro 
                85                  90                  95      


Lys Leu Asn Gly Ser Gly Pro Ser Trp Trp Pro Glu Cys Thr Cys Thr 
            100                 105                 110         


Asn Arg Asp Trp Tyr Glu Gln Val Asn Gly Ser Asp Gly Met Phe Lys 
        115                 120                 125             


Tyr Glu Glu Ile Val Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser 
    130                 135                 140                 


Ile Ala Gly Gly Ile Asp Asn Pro His Val Pro Asp Asp Pro Gly Ile 
145                 150                 155                 160 


Phe Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Met Asp Gly Arg 
                165                 170                 175     


Leu Gly Val Asn Asp Cys Val Leu Arg Val Asn Glu Val Asp Val Ser 
            180                 185                 190         


Glu Val Val His Ser Arg Ala Val Glu Ala Leu Lys Glu Ala Gly Pro 
        195                 200                 205             


Val Val Arg Leu Val Val Arg Arg Arg Gln Pro Pro Pro Glu Thr Ile 
    210                 215                 220                 


Met Glu Val Asn Leu Leu Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile 
225                 230                 235                 240 


Ala Gly Gly Ile Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr 
                245                 250                 255     


Ile Thr Lys Ile Ile Glu Gly Gly Ala Ala Gln Lys Asp Gly Arg Leu 
            260                 265                 270         


Gln Ile Gly Asp Arg Leu Leu Ala Val Asn Asn Thr Asn Leu Gln Asp 
        275                 280                 285             


Val Arg His Glu Glu Ala Val Ala Ser Leu Lys Asn Thr Ser Asp Met 
    290                 295                 300                 


Val Tyr Leu Lys Val Ala Lys Pro Gly Ser Leu His Leu Asn Asp Met 
305                 310                 315                 320 


Tyr Ala Pro Pro Asp Tyr Ala Ser Thr Phe Thr Ala Leu Ala Asp Asn 
                325                 330                 335     


His Ile Ser His Asn Ser Ser Leu Gly Tyr Leu Gly Ala Val Glu Ser 
            340                 345                 350         


Lys Val Ser Tyr Pro Ala Pro Pro Gln Val Pro Pro Thr Arg Tyr Ser 
        355                 360                 365             


Pro Ile Pro Arg His Met Leu Ala Glu Glu Asp Phe Thr Arg Glu Pro 
    370                 375                 380                 


Arg Lys Ile Ile Leu His Lys Gly Ser Thr Gly Leu Gly Phe Asn Ile 
385                 390                 395                 400 


Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Val Ser Phe Ile Leu Ala 
                405                 410                 415     


Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Arg Gly Asp Arg Ile 
            420                 425                 430         


Leu Ser Val Asn Gly Val Asn Leu Arg Asn Ala Thr His Glu Gln Ala 
        435                 440                 445             


Ala Ala Ala Leu Lys Arg Ala Gly Gln Ser Val Thr Ile Val Ala Gln 
    450                 455                 460                 


Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ser Lys Ile His Asp Leu 
465                 470                 475                 480 


Arg Glu Gln Met Met Asn Ser Ser Met Ser Ser Gly Ser Gly Ser Leu 
                485                 490                 495     


Arg Thr Ser Glu Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp Tyr 
            500                 505                 510         


Asp Arg Thr Arg Asp Ser Cys Leu Pro Ser Gln Gly Leu Ser Phe Ser 
        515                 520                 525             


Tyr Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp 
    530                 535                 540                 


Gln Ala Arg Leu Val Thr Pro His Gly Glu Ser Glu Gln Ile Gly Val 
545                 550                 555                 560 


Ile Pro Ser Lys Lys Arg Val Glu Lys Lys Glu Arg Ala Arg Leu Lys 
                565                 570                 575     


Thr Val Lys Phe His Ala Arg Thr Gly Met Ile Glu Ser Asn Arg Asp 
            580                 585                 590         


Phe Pro Gly Leu Ser Asp Asp Tyr Tyr Gly Ala Lys Asn Leu Lys Gly 
        595                 600                 605             


Gln Glu Asp Ala Ile Leu Ser Tyr Glu Pro Val Thr Arg Gln Glu Ile 
    610                 615                 620                 


His Tyr Ala Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Val 
625                 630                 635                 640 


Asn Asp Asp Leu Ile Ser Glu Phe Pro His Lys Phe Gly Ser Cys Val 
                645                 650                 655     


Pro His Thr Thr Arg Pro Arg Arg Asp Asn Glu Val Asp Gly Gln Asp 
            660                 665                 670         


Tyr His Phe Val Val Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Asp 
        675                 680                 685             


Asn Lys Phe Ile Glu Ala Gly Gln Phe Asn Asp Asn Leu Tyr Gly Thr 
    690                 695                 700                 


Ser Ile Gln Ser Val Arg Ala Val Ala Glu Arg Gly Lys His Cys Ile 
705                 710                 715                 720 


Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Gln Ala Gln Leu 
                725                 730                 735     


Tyr Pro Ile Ala Ile Phe Ile Lys Pro Lys Ser Ile Glu Ala Leu Met 
            740                 745                 750         


Glu Met Asn Arg Arg Gln Thr Tyr Glu Gln Ala Asn Lys Ile Tyr Asp 
        755                 760                 765             


Lys Ala Met Lys Leu Glu Gln Glu Phe Gly Glu Tyr Phe Thr Ala Ile 
    770                 775                 780                 


Val Gln Gly Asp Ser Leu Glu Glu Ile Tyr Asn Lys Ile Lys Gln Ile 
785                 790                 795                 800 


Ile Glu Asp Gln Ser Gly His Tyr Ile Trp Val Pro Ser Pro Glu Lys 
                805                 810                 815     


Leu 
    


<210>  9
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr 
    50                  55                  60                  


Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr 
65                  70                  75                  80  


Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile 
                85                  90                  95      


Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp 
            100                 105                 110         


Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser 
        115                 120                 125             


Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr 
    130                 135                 140                 


Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu 
145                 150                 155                 160 


Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly 
                165                 170                 175     


Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile 
            180                 185                 190         


Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys 
        195                 200                 205             


Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp 
    210                 215                 220                 


Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val 
225                 230                 235                 240 


Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp 
                245                 250                 255     


Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser 
            260                 265                 270         


Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro 
        275                 280                 285             


Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile 
    290                 295                 300                 


Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu 
305                 310                 315                 320 


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
                325                 330                 335     


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
            340                 345                 350         


Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser 
        355                 360                 365             


His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr 
    370                 375                 380                 


Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
385                 390                 395                 400 


Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly 
                405                 410                 415     


Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala 
            420                 425                 430         


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala 
        435                 440                 445             


Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp 
    450                 455                 460                 


Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp 
465                 470                 475                 480 


Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp 
                485                 490                 495     


Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly 
            500                 505                 510         


Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val 
        515                 520                 525             


His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala 
    530                 535                 540                 


Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val 
545                 550                 555                 560 


Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp 
                565                 570                 575     


Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala 
            580                 585                 590         


His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr 
        595                 600                 605             


Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile 
    610                 615                 620                 


Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu 
625                 630                 635                 640 


His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu 
                645                 650                 655     


Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp 
            660                 665                 670         


Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile 
        675                 680                 685             


Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val 
    690                 695                 700                 


Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg 
705                 710                 715                 720 


Leu 
    


<210>  10
<211>  975
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Ile Phe Lys Ser Ser Leu Phe Gln Ala Leu Leu Asp Ile Gln 
1               5                   10                  15      


Glu Phe Tyr Glu Val Thr Leu Leu Asn Ser Gln Lys Ser Cys Glu Gln 
            20                  25                  30          


Lys Ile Glu Glu Ala Asn Gln Val Leu Gln Lys Trp Glu Lys Thr Ser 
        35                  40                  45              


Leu Leu Ala Pro Cys His Asp Arg Leu Gln Lys Ser Ser Glu Leu Thr 
    50                  55                  60                  


Asp Cys Ser Gly Ser Lys Glu Asn Ala Ser Cys Ile Glu Gln Asn Lys 
65                  70                  75                  80  


Glu Asn Gln Ser Phe Glu Asn Glu Thr Asp Glu Thr Thr Thr Gln Asn 
                85                  90                  95      


Gln Gly Arg Cys Pro Ala Gln Asn Cys Ser Val Glu Ala Pro Ala Trp 
            100                 105                 110         


Met Pro Val His His Cys Thr Lys Tyr Arg Tyr Gln Asp Glu Asp Ala 
        115                 120                 125             


Pro His Asp His Ser Leu Pro Arg Leu Thr His Glu Val Arg Gly Pro 
    130                 135                 140                 


Glu Leu Val His Val Ser Glu Lys Asn Leu Ser Gln Ile Glu Asn Val 
145                 150                 155                 160 


His Gly Tyr Val Leu Gln Ser His Ile Ser Pro Leu Lys Ala Ser Pro 
                165                 170                 175     


Ala Pro Ile Ile Val Asn Thr Asp Thr Leu Asp Thr Ile Pro Tyr Val 
            180                 185                 190         


Asn Gly Thr Glu Ile Glu Tyr Glu Phe Glu Glu Ile Thr Leu Glu Arg 
        195                 200                 205             


Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn Pro 
    210                 215                 220                 


His Ile Gly Asp Asp Pro Gly Ile Phe Ile Thr Lys Ile Ile Pro Gly 
225                 230                 235                 240 


Gly Ala Ala Ala Glu Asp Gly Arg Leu Arg Val Asn Asp Cys Ile Leu 
                245                 250                 255     


Arg Val Asn Glu Val Asp Val Ser Glu Val Ser His Ser Lys Ala Val 
            260                 265                 270         


Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Arg Arg 
        275                 280                 285             


Arg Arg Pro Ile Leu Glu Thr Val Val Glu Ile Lys Leu Phe Lys Gly 
    290                 295                 300                 


Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln His 
305                 310                 315                 320 


Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Asp Gly Gly 
                325                 330                 335     


Ala Ala Gln Lys Asp Gly Arg Leu Gln Val Gly Asp Arg Leu Leu Met 
            340                 345                 350         


Val Asn Asn Tyr Ser Leu Glu Glu Val Thr His Glu Glu Ala Val Ala 
        355                 360                 365             


Ile Leu Lys Asn Thr Ser Glu Val Val Tyr Leu Lys Val Gly Lys Pro 
    370                 375                 380                 


Thr Thr Ile Tyr Met Thr Asp Pro Tyr Gly Pro Pro Asp Ile Thr His 
385                 390                 395                 400 


Ser Tyr Ser Pro Pro Met Glu Asn His Leu Leu Ser Gly Asn Asn Gly 
                405                 410                 415     


Thr Leu Glu Tyr Lys Thr Ser Leu Pro Pro Ile Ser Pro Gly Arg Tyr 
            420                 425                 430         


Ser Pro Ile Pro Lys His Met Leu Val Asp Asp Asp Tyr Thr Arg Pro 
        435                 440                 445             


Pro Glu Pro Val Tyr Ser Thr Val Asn Lys Leu Cys Asp Lys Pro Ala 
    450                 455                 460                 


Ser Pro Arg His Tyr Ser Pro Val Glu Cys Asp Lys Ser Phe Leu Leu 
465                 470                 475                 480 


Ser Ala Pro Tyr Ser His Tyr His Leu Gly Leu Leu Pro Asp Ser Glu 
                485                 490                 495     


Met Thr Ser His Ser Gln His Ser Thr Ala Thr Arg Gln Pro Ser Met 
            500                 505                 510         


Thr Leu Gln Arg Ala Val Ser Leu Glu Gly Glu Pro Arg Lys Val Val 
        515                 520                 525             


Leu His Lys Gly Ser Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu 
    530                 535                 540                 


Asp Gly Glu Gly Ile Phe Val Ser Phe Ile Leu Ala Gly Gly Pro Ala 
545                 550                 555                 560 


Asp Leu Ser Gly Glu Leu Gln Arg Gly Asp Gln Ile Leu Ser Val Asn 
                565                 570                 575     


Gly Ile Asp Leu Arg Gly Ala Ser His Glu Gln Ala Ala Ala Ala Leu 
            580                 585                 590         


Lys Gly Ala Gly Gln Thr Val Thr Ile Ile Ala Gln Tyr Gln Pro Glu 
        595                 600                 605             


Asp Tyr Ala Arg Phe Glu Ala Lys Ile His Asp Leu Arg Glu Gln Met 
    610                 615                 620                 


Met Asn His Ser Met Ser Ser Gly Ser Gly Ser Leu Arg Thr Asn Gln 
625                 630                 635                 640 


Lys Arg Ser Leu Tyr Val Arg Ala Met Phe Asp Tyr Asp Lys Ser Lys 
                645                 650                 655     


Asp Ser Gly Leu Pro Ser Gln Gly Leu Ser Phe Lys Tyr Gly Asp Ile 
            660                 665                 670         


Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp Gln Ala Arg Arg 
        675                 680                 685             


Val Met Leu Glu Gly Asp Ser Glu Glu Met Gly Val Ile Pro Ser Lys 
    690                 695                 700                 


Arg Arg Val Glu Arg Lys Glu Arg Ala Arg Leu Lys Thr Val Lys Phe 
705                 710                 715                 720 


Asn Ala Lys Pro Gly Val Ile Asp Ser Lys Gly Ser Phe Asn Asp Lys 
                725                 730                 735     


Arg Lys Lys Ser Phe Ile Phe Ser Arg Lys Phe Pro Phe Tyr Lys Asn 
            740                 745                 750         


Lys Glu Gln Ser Glu Gln Glu Thr Ser Asp Pro Glu Arg Gly Gln Glu 
        755                 760                 765             


Asp Leu Ile Leu Ser Tyr Glu Pro Val Thr Arg Gln Glu Ile Asn Tyr 
    770                 775                 780                 


Thr Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp 
785                 790                 795                 800 


Asp Leu Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
                805                 810                 815     


Thr Thr Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His 
            820                 825                 830         


Phe Val Ile Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys 
        835                 840                 845             


Phe Ile Glu Ala Gly Gln Tyr Asn Asp Asn Leu Tyr Gly Thr Ser Val 
    850                 855                 860                 


Gln Ser Val Arg Phe Val Ala Glu Arg Gly Lys His Cys Ile Leu Asp 
865                 870                 875                 880 


Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Val Ala Gln Leu Tyr Pro 
                885                 890                 895     


Ile Ala Ile Phe Ile Lys Pro Arg Ser Leu Glu Pro Leu Met Glu Met 
            900                 905                 910         


Asn Lys Arg Leu Thr Glu Glu Gln Ala Lys Lys Thr Tyr Asp Arg Ala 
        915                 920                 925             


Ile Lys Leu Glu Gln Glu Phe Gly Glu Tyr Phe Thr Ala Ile Val Gln 
    930                 935                 940                 


Gly Asp Thr Leu Glu Asp Ile Tyr Asn Gln Cys Lys Leu Val Ile Glu 
945                 950                 955                 960 


Glu Gln Ser Gly Pro Phe Ile Trp Ile Pro Ser Lys Glu Lys Leu 
                965                 970                 975 


