                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
       Bayer Healthcare LLC 
 
<120>  MATERIALS AND METHODS FOR CONTROLLING GENE EDITING

<130>  CBTN-005PC

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  62/868,209
<151>  2019-06-28

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  1
gacgggugug guacgcagcc acuguuuaag uacucugugc uggaaacagc acagaaucua       60

cuuaaacaag gcaaaaugcc guguuuaucu cgucaacuug uuggcgagau uuuuu           115


<210>  2
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  2
ggguguggua cgcagccacu guuuaaguac ucugugcugg aaacagcaca gaaucuacuu       60

aaacaaggca aaaugccgug uuuaucucgu caacuuguug gcgagauuuu uu              112


<210>  3
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated  H1 promoter comprising 2 TetO sites

<400>  3
gaacgctgac gtcatcaacc cgctccaagg aatcgcgggc ccagtgtcac taggcgggaa       60

cacccagcgc gcgtgcgccc tggcaggaag atggctgtga gggacagggg agtggcgccc      120

tgcaatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatccctatc      180

agtgatagag acttataagt tccctatcag tgatagagac acc                        223


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TetO site sequence

<400>  4
tccctatcag tgatagaga                                                    19


<210>  5
<211>  6805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  5
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggatcca agcggaacta      420

tatcctggga ctggacatcg gaattacctc cgtgggatac ggcatcatcg attacgagac      480

tagggacgtg attgacgccg gcgtgagact ctttaaggag gccaacgtgg aaaacaacga      540

aggtcgcaga tccaagcggg gtgcaagacg cctgaagcgc cggaggagac atcggataca      600

gcgcgtgaag aagctccttt tcgactacaa cctcctcact gaccactcgg aattgtccgg      660

tatcaacccc tacgaagccc gcgtgaaagg cctgagccag aagctgtccg aagaggagtt      720

tagcgcagcc ctgctgcacc tggctaagcg aaggggggtg cacaacgtga acgaggtgga      780

ggaggacact ggcaacgaac tgtccaccaa ggagcagatt tcacggaact cgaaggcgct      840

ggaagagaaa tatgtggccg agctgcagct ggagaggctc aagaaggatg gcgaagtccg      900

ggggagcatc aatcgcttca agacctcgga ctacgtgaag gaagccaaac agctgttgaa      960

ggtgcagaag gcctaccacc aactggacca atcattcatt gacacttaca tcgatctgct     1020

tgaaaccagg cgcacctact acgagggtcc tggagaaggc agccctttcg gatggaagga     1080

catcaaggag tggtatgaga tgctgatggg tcattgcacc tactttccgg aagaactgcg     1140

ctcagtgaag tacgcgtaca acgctgacct ctacaacgct ctcaacgatc tgaacaacct     1200

cgtgatcacc cgggacgaga acgaaaagct ggagtactac gaaaagttcc agattatcga     1260

aaacgtgttc aagcagaaga agaagcccac cctgaagcag attgcaaagg agatccttgt     1320

gaacgaggag gatattaagg gctaccgggt cacctccacc gggaaaccag agttcactaa     1380

tctcaaggtg taccatgaca ttaaggacat tactgcccgc aaggagatca ttgaaaacgc     1440

ggaactgctg gaccaaatcg cgaagatcct gaccatctat cagagctccg aggatatcca     1500

ggaggaactt actaacctca attccgagct gacgcaggaa gaaatcgagc aaattagcaa     1560

cctgaagggt tacactggaa cccacaacct cagcttgaaa gcgattaacc ttattttgga     1620

tgaactttgg cacactaatg acaatcagat cgccattttc aaccggctga aactggtgcc     1680

gaagaaggtg gacctgagcc aacagaagga aatcccgacc acccttgtgg acgatttcat     1740

cctgtcacct gtggtgaaga ggagcttcat ccagtcgatc aaggtcatca acgccatcat     1800

aaagaagtac ggccttccca acgacatcat catcgaactg gcccgcgaga agaactccaa     1860

agatgcccag aagatgatca acgagatgca gaagcgaaac cggcagacga acgaacggat     1920

cgaggagatc atccggacca ccgggaagga aaacgcgaag tacctgatcg agaaaatcaa     1980

gctgcatgat atgcaggaag ggaagtgtct ctactccctg gaggccattc cgctggagga     2040

tttgctgaac aaccctttca actacgaagt cgatcatatc attcctcgct ccgtgtcctt     2100

cgataactcc ttcaacaata aggtcctcgt gaagcaggag gagaagtaag tatcaaggtt     2160

acaagacagg tttaaggaga ccaatagaaa ctgggctcga gcttgtcgag acagagaaga     2220

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc     2280

acagctcgaa gaagggcaac agaaccccgt tccagtacct ctcgtcgtcc gactccaaga     2340

tcagctacga aactttcaag aagcacattc tgaacctggc caagggcaaa gggagaatta     2400

gcaagaccaa gaaggaatac ctcctggaag agagagacat caaccgcttc tcggtgcaaa     2460

aggatttcat caaccgcaac ctggtcgata ccagatacgc caccagggga ctgatgaacc     2520

tcctgcggtc ctacttccgg gtcaacaatc tggacgtgaa ggtcaaatcc atcaacgggg     2580

gctttacttc tttcctgcgc cggaagtgga agttcaagaa ggaacggaac aagggataca     2640

agcaccacgc tgaagatgcc ctgattattg ccaacgccga cttcatcttt aaggaatgga     2700

aaaagctgga caaggctaag aaggtcatgg agaaccagat gttcgaagaa aagcaggccg     2760

agtccatgcc cgaaatcgaa accgagcagg aatacaagga gatcttcatc acaccgcacc     2820

aaatcaagca catcaaggac ttcaaggatt acaagtacag ccaccgggtg gacaagaagc     2880

ctaacagaga gcttatcaac gacaccctgt actccacgcg caaggacgac aagggaaaca     2940

cattgatcgt gaacaacctg aacggactgt atgacaagga caatgacaaa ctgaagaagc     3000

tgatcaacaa atcgccggaa aagctcctga tgtaccatca cgaccctcaa acctaccaga     3060

aactgaagct catcatggag cagtacggcg acgaaaagaa tcccctgtac aaatactacg     3120

aggagactgg aaattacctg actaagtact ccaagaagga taacggcccc gtgatcaaga     3180

agattaagta ctacggaaac aaactgaacg cacatctcga catcaccgat gattatccaa     3240

actcccgcaa caaagtcgtg aagctctccc tcaaaccgta ccgcttcgac gtgtacctgg     3300

ataatggggt gtacaagttc gtgaccgtga agaacctgga cgtcattaag aaggaaaact     3360

actacgaagt gaactcaaag tgctacgagg aagccaagaa gctcaagaag atcagcaacc     3420

aggccgagtt catcgcatcg ttttacaaca atgacctcat taagattaat ggagaactgt     3480

acagagtgat cggcgtgaac aacgacctcc tgaaccggat tgaagtgaac atgatcgata     3540

ttacctaccg ggagtatctg gagaacatga acgacaagcg cccaccgaga atcatcaaaa     3600

ctattgcctc caagacccaa tccattaaga aatactccac cgacatcctg ggcaacctgt     3660

acgaggtcaa gtcgaagaag cacccccaga ttatcaagaa gggaaaaagg ccggcggcca     3720

cgaaaaaggc cggccaggca aaaaagaaaa aggcttaaga attcctagag ctcgctgatc     3780

agcctcgaaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     3840

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     3900

atgtatctta tcatgtctgt ataccagcag gctttcctag gttcgaacgc tgacgtcatc     3960

aacccgctcc aaggaatcgc gggcccagtg tcactaggcg ggaacaccca gcgcgcgtgc     4020

gccctggcag gaagatggct gtgagggaca ggggagtggc gccctgcaat atttgcatgt     4080

cgctatgtgt tctgggaaat caccataaac gtgaaatccc tatcagtgat agagacttat     4140

aagttcccta tcagtgatag agacaccgac gggtgtggta cgcagccact gtttaagtac     4200

tctgtgctgg aaacagcaca gaatctactt aaacaaggca aaatgccgtg tttatctcgt     4260

caacttgttg gcgagatttt ttcacgtgcg gaccgaggct gcagcgtcgt cctccctagg     4320

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4380

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     4440

cgcgcagctg cctgcagggg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta     4500

tttcacaccg catacgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc     4560

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     4620

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     4680

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     4740

acttgatttg ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     4800

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     4860

caaccctatc tcgggctatt cttttgattt ataagggatt ttgccgattt cggcctattg     4920

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt     4980

tacaatttta tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc     5040

ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc     5100

ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc     5160

accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat     5220

gaacaataaa actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc     5280

aacgggaaac gtcgaggccg cgattaaatt ccaacatgga tgctgattta tatgggtata     5340

aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgcttg tatgggaagc     5400

ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat gatgttacag     5460

atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc atcaagcatt     5520

ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccgga aaaacagcat     5580

tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt     5640

tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc gatcgcgtat     5700

ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg agtgattttg     5760

atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat aaacttttgc     5820

cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac cttatttttg     5880

acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca gaccgatacc     5940

aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta cagaaacggc     6000

tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt catttgatgc     6060

tcgatgagtt tttctaatct catgaccaaa atcccttaac gtgagttttc gttccactga     6120

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     6180

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     6240

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     6300

gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     6360

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     6420

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     6480

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     6540

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     6600

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     6660

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     6720

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     6780

ttttgctggc cttttgctca catgt                                           6805


<210>  6
<211>  8353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  6
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggatcca agcggaacta      420

tatcctggga ctggacatcg gaattacctc cgtgggatac ggcatcatcg attacgagac      480

tagggacgtg attgacgccg gcgtgagact ctttaaggag gccaacgtgg aaaacaacga      540

aggtcgcaga tccaagcggg gtgcaagacg cctgaagcgc cggaggagac atcggataca      600

gcgcgtgaag aagctccttt tcgactacaa cctcctcact gaccactcgg aattgtccgg      660

tatcaacccc tacgaagccc gcgtgaaagg cctgagccag aagctgtccg aagaggagtt      720

tagcgcagcc ctgctgcacc tggctaagcg aaggggggtg cacaacgtga acgaggtgga      780

ggaggacact ggcaacgaac tgtccaccaa ggagcagatt tcacggaact cgaaggcgct      840

ggaagagaaa tatgtggccg agctgcagct ggagaggctc aagaaggatg gcgaagtccg      900

ggggagcatc aatcgcttca agacctcgga ctacgtgaag gaagccaaac agctgttgaa      960

ggtgcagaag gcctaccacc aactggacca atcattcatt gacacttaca tcgatctgct     1020

tgaaaccagg cgcacctact acgagggtcc tggagaaggc agccctttcg gatggaagga     1080

catcaaggag tggtatgaga tgctgatggg tcattgcacc tactttccgg aagaactgcg     1140

ctcagtgaag tacgcgtaca acgctgacct ctacaacgct ctcaacgatc tgaacaacct     1200

cgtgatcacc cgggacgaga acgaaaagct ggagtactac gaaaagttcc agattatcga     1260

aaacgtgttc aagcagaaga agaagcccac cctgaagcag attgcaaagg agatccttgt     1320

gaacgaggag gatattaagg gctaccgggt cacctccacc gggaaaccag agttcactaa     1380

tctcaaggtg taccatgaca ttaaggacat tactgcccgc aaggagatca ttgaaaacgc     1440

ggaactgctg gaccaaatcg cgaagatcct gaccatctat cagagctccg aggatatcca     1500

ggaggaactt actaacctca attccgagct gacgcaggaa gaaatcgagc aaattagcaa     1560

cctgaagggt tacactggaa cccacaacct cagcttgaaa gcgattaacc ttattttgga     1620

tgaactttgg cacactaatg acaatcagat cgccattttc aaccggctga aactggtgcc     1680

gaagaaggtg gacctgagcc aacagaagga aatcccgacc acccttgtgg acgatttcat     1740

cctgtcacct gtggtgaaga ggagcttcat ccagtcgatc aaggtcatca acgccatcat     1800

aaagaagtac ggccttccca acgacatcat catcgaactg gcccgcgaga agaactccaa     1860

agatgcccag aagatgatca acgagatgca gaagcgaaac cggcagacga acgaacggat     1920

cgaggagatc atccggacca ccgggaagga aaacgcgaag tacctgatcg agaaaatcaa     1980

gctgcatgat atgcaggaag ggaagtgtct ctactccctg gaggccattc cgctggagga     2040

tttgctgaac aaccctttca actacgaagt cgatcatatc attcctcgct ccgtgtcctt     2100

cgataactcc ttcaacaata aggtcctcgt gaagcaggag gagaagtaag tatcaaggtt     2160

acaagacagg tttaaggaga ccaatagaaa ctgggctcga gcttgtcgag acagagaaga     2220

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc     2280

acagctcgaa gaagggcaac agaaccccgt tccagtacct ctcgtcgtcc gactccaaga     2340

tcagctacga aactttcaag aagcacattc tgaacctggc caagggcaaa gggagaatta     2400

gcaagaccaa gaaggaatac ctcctggaag agagagacat caaccgcttc tcggtgcaaa     2460

aggatttcat caaccgcaac ctggtcgata ccagatacgc caccagggga ctgatgaacc     2520

tcctgcggtc ctacttccgg gtcaacaatc tggacgtgaa ggtcaaatcc atcaacgggg     2580

gctttacttc tttcctgcgc cggaagtgga agttcaagaa ggaacggaac aagggataca     2640

agcaccacgc tgaagatgcc ctgattattg ccaacgccga cttcatcttt aaggaatgga     2700

aaaagctgga caaggctaag aaggtcatgg agaaccagat gttcgaagaa aagcaggccg     2760

agtccatgcc cgaaatcgaa accgagcagg aatacaagga gatcttcatc acaccgcacc     2820

aaatcaagca catcaaggac ttcaaggatt acaagtacag ccaccgggtg gacaagaagc     2880

ctaacagaga gcttatcaac gacaccctgt actccacgcg caaggacgac aagggaaaca     2940

cattgatcgt gaacaacctg aacggactgt atgacaagga caatgacaaa ctgaagaagc     3000

tgatcaacaa atcgccggaa aagctcctga tgtaccatca cgaccctcaa acctaccaga     3060

aactgaagct catcatggag cagtacggcg acgaaaagaa tcccctgtac aaatactacg     3120

aggagactgg aaattacctg actaagtact ccaagaagga taacggcccc gtgatcaaga     3180

agattaagta ctacggaaac aaactgaacg cacatctcga catcaccgat gattatccaa     3240

actcccgcaa caaagtcgtg aagctctccc tcaaaccgta ccgcttcgac gtgtacctgg     3300

ataatggggt gtacaagttc gtgaccgtga agaacctgga cgtcattaag aaggaaaact     3360

actacgaagt gaactcaaag tgctacgagg aagccaagaa gctcaagaag atcagcaacc     3420

aggccgagtt catcgcatcg ttttacaaca atgacctcat taagattaat ggagaactgt     3480

acagagtgat cggcgtgaac aacgacctcc tgaaccggat tgaagtgaac atgatcgata     3540

ttacctaccg ggagtatctg gagaacatga acgacaagcg cccaccgaga atcatcaaaa     3600

ctattgcctc caagacccaa tccattaaga aatactccac cgacatcctg ggcaacctgt     3660

acgaggtcaa gtcgaagaag cacccccaga ttatcaagaa gggaaaaagg ccggcggcca     3720

cgaaaaaggc cggccaggca aaaaagaaaa aggcttaaga attcctagag ctcgctgatc     3780

agcctcgaaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     3840

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     3900

atgtatctta tcatgtctgt ataccagcag gctttcctag gttcgaacgc tgacgtcatc     3960

aacccgctcc aaggaatcgc gggcccagtg tcactaggcg ggaacaccca gcgcgcgtgc     4020

gccctggcag gaagatggct gtgagggaca ggggagtggc gccctgcaat atttgcatgt     4080

cgctatgtgt tctgggaaat caccataaac gtgaaatccc tatcagtgat agagacttat     4140

aagttcccta tcagtgatag agacaccgac gggtgtggta cgcagccact gtttaagtac     4200

tctgtgctgg aaacagcaca gaatctactt aaacaaggca aaatgccgtg tttatctcgt     4260

caacttgttg gcgagatttt ttcacgtgcg gaccgaggct gcagcgtcgt cctccctagg     4320

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4380

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     4440

cgcgcagctg cctgcagggg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta     4500

tttcacaccg catacgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc     4560

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     4620

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     4680

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     4740

acttgatttg ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     4800

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     4860

caaccctatc tcgggctatt cttttgattt ataagggatt ttgccgattt cggcctattg     4920

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt     4980

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     5040

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     5100

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     5160

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     5220

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     5280

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat     5340

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc     5400

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     5460

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa     5520

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag     5580

aacccactgc ttactggctt atcgttaatt aaccggtgcc accatgatgt cccgccttga     5640

taaatcaaaa gtaataaaca gtgctcttga gcttctcaat gaagttggta tagaagggtt     5700

gacgactcgg aaattggcgc aaaaactcgg tgttgagcag ccaaccttgt attggcatgt     5760

taaaaacaaa cgagcactcc tcgacgcttt ggcgatagag atgctggaca ggcaccacac     5820

gcatttctgt cccctcgaag gagagtcatg gcaggatttc cttagaaata acgcaaagtc     5880

cttcagatgt gcgctgctta gtcaccgcga cggcgcaaaa gttcatctcg gcactaggcc     5940

aaccgagaaa cagtacgaga ctctggagaa ccaactggcg tttttgtgtc aacagggttt     6000

tagtctcgaa aatgcgctct atgctctctc tgcggttggc catttcaccc tcggatgcgt     6060

actggaagat caggagcacc aagtggccaa agaagaacgg gaaacgccga ctacggacag     6120

catgcctccg ttgctccggc aagctataga gctcttcgat caccaaggcg ctgagccagc     6180

tttcttgttc ggattggaac ttattatatg cgggctcgaa aagcagctta aatgcgagtc     6240

aggttaagcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca gcctcgactg     6300

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     6360

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     6420

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     6480

aagacaatag caggcatgct ggggatgcgg tgggctctat ggaacgttta caattttatg     6540

gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc     6600

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc     6660

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc     6720

gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga acaataaaac     6780

tgtctgctta cataaacagt aatacaaggg gtgttatgag ccatattcaa cgggaaacgt     6840

cgaggccgcg attaaattcc aacatggatg ctgatttata tgggtataaa tgggctcgcg     6900

ataatgtcgg gcaatcaggt gcgacaatct atcgcttgta tgggaagccc gatgcgccag     6960

agttgtttct gaaacatggc aaaggtagcg ttgccaatga tgttacagat gagatggtca     7020

gactaaactg gctgacggaa tttatgcctc ttccgaccat caagcatttt atccgtactc     7080

ctgatgatgc atggttactc accactgcga tccccggaaa aacagcattc caggtattag     7140

aagaatatcc tgattcaggt gaaaatattg ttgatgcgct ggcagtgttc ctgcgccggt     7200

tgcattcgat tcctgtttgt aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc     7260

aggcgcaatc acgaatgaat aacggtttgg ttgatgcgag tgattttgat gacgagcgta     7320

atggctggcc tgttgaacaa gtctggaaag aaatgcataa acttttgcca ttctcaccgg     7380

attcagtcgt cactcatggt gatttctcac ttgataacct tatttttgac gaggggaaat     7440

taataggttg tattgatgtt ggacgagtcg gaatcgcaga ccgataccag gatcttgcca     7500

tcctatggaa ctgcctcggt gagttttctc cttcattaca gaaacggctt tttcaaaaat     7560

atggtattga taatcctgat atgaataaat tgcagtttca tttgatgctc gatgagtttt     7620

tctaatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     7680

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     7740

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     7800

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     7860

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     7920

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     7980

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     8040

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     8100

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     8160

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     8220

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     8280

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     8340

tttgctcaca tgt                                                        8353


<210>  7
<211>  6802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  7
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggatcca agcggaacta      420

tatcctggga ctggacatcg gaattacctc cgtgggatac ggcatcatcg attacgagac      480

tagggacgtg attgacgccg gcgtgagact ctttaaggag gccaacgtgg aaaacaacga      540

aggtcgcaga tccaagcggg gtgcaagacg cctgaagcgc cggaggagac atcggataca      600

gcgcgtgaag aagctccttt tcgactacaa cctcctcact gaccactcgg aattgtccgg      660

tatcaacccc tacgaagccc gcgtgaaagg cctgagccag aagctgtccg aagaggagtt      720

tagcgcagcc ctgctgcacc tggctaagcg aaggggggtg cacaacgtga acgaggtgga      780

ggaggacact ggcaacgaac tgtccaccaa ggagcagatt tcacggaact cgaaggcgct      840

ggaagagaaa tatgtggccg agctgcagct ggagaggctc aagaaggatg gcgaagtccg      900

ggggagcatc aatcgcttca agacctcgga ctacgtgaag gaagccaaac agctgttgaa      960

ggtgcagaag gcctaccacc aactggacca atcattcatt gacacttaca tcgatctgct     1020

tgaaaccagg cgcacctact acgagggtcc tggagaaggc agccctttcg gatggaagga     1080

catcaaggag tggtatgaga tgctgatggg tcattgcacc tactttccgg aagaactgcg     1140

ctcagtgaag tacgcgtaca acgctgacct ctacaacgct ctcaacgatc tgaacaacct     1200

cgtgatcacc cgggacgaga acgaaaagct ggagtactac gaaaagttcc agattatcga     1260

aaacgtgttc aagcagaaga agaagcccac cctgaagcag attgcaaagg agatccttgt     1320

gaacgaggag gatattaagg gctaccgggt cacctccacc gggaaaccag agttcactaa     1380

tctcaaggtg taccatgaca ttaaggacat tactgcccgc aaggagatca ttgaaaacgc     1440

ggaactgctg gaccaaatcg cgaagatcct gaccatctat cagagctccg aggatatcca     1500

ggaggaactt actaacctca attccgagct gacgcaggaa gaaatcgagc aaattagcaa     1560

cctgaagggt tacactggaa cccacaacct cagcttgaaa gcgattaacc ttattttgga     1620

tgaactttgg cacactaatg acaatcagat cgccattttc aaccggctga aactggtgcc     1680

gaagaaggtg gacctgagcc aacagaagga aatcccgacc acccttgtgg acgatttcat     1740

cctgtcacct gtggtgaaga ggagcttcat ccagtcgatc aaggtcatca acgccatcat     1800

aaagaagtac ggccttccca acgacatcat catcgaactg gcccgcgaga agaactccaa     1860

agatgcccag aagatgatca acgagatgca gaagcgaaac cggcagacga acgaacggat     1920

cgaggagatc atccggacca ccgggaagga aaacgcgaag tacctgatcg agaaaatcaa     1980

gctgcatgat atgcaggaag ggaagtgtct ctactccctg gaggccattc cgctggagga     2040

tttgctgaac aaccctttca actacgaagt cgatcatatc attcctcgct ccgtgtcctt     2100

cgataactcc ttcaacaata aggtcctcgt gaagcaggag gagaagtaag tatcaaggtt     2160

acaagacagg tttaaggaga ccaatagaaa ctgggctcga gcttgtcgag acagagaaga     2220

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc     2280

acagctcgaa gaagggcaac agaaccccgt tccagtacct ctcgtcgtcc gactccaaga     2340

tcagctacga aactttcaag aagcacattc tgaacctggc caagggcaaa gggagaatta     2400

gcaagaccaa gaaggaatac ctcctggaag agagagacat caaccgcttc tcggtgcaaa     2460

aggatttcat caaccgcaac ctggtcgata ccagatacgc caccagggga ctgatgaacc     2520

tcctgcggtc ctacttccgg gtcaacaatc tggacgtgaa ggtcaaatcc atcaacgggg     2580

gctttacttc tttcctgcgc cggaagtgga agttcaagaa ggaacggaac aagggataca     2640

agcaccacgc tgaagatgcc ctgattattg ccaacgccga cttcatcttt aaggaatgga     2700

aaaagctgga caaggctaag aaggtcatgg agaaccagat gttcgaagaa aagcaggccg     2760

agtccatgcc cgaaatcgaa accgagcagg aatacaagga gatcttcatc acaccgcacc     2820

aaatcaagca catcaaggac ttcaaggatt acaagtacag ccaccgggtg gacaagaagc     2880

ctaacagaga gcttatcaac gacaccctgt actccacgcg caaggacgac aagggaaaca     2940

cattgatcgt gaacaacctg aacggactgt atgacaagga caatgacaaa ctgaagaagc     3000

tgatcaacaa atcgccggaa aagctcctga tgtaccatca cgaccctcaa acctaccaga     3060

aactgaagct catcatggag cagtacggcg acgaaaagaa tcccctgtac aaatactacg     3120

aggagactgg aaattacctg actaagtact ccaagaagga taacggcccc gtgatcaaga     3180

agattaagta ctacggaaac aaactgaacg cacatctcga catcaccgat gattatccaa     3240

actcccgcaa caaagtcgtg aagctctccc tcaaaccgta ccgcttcgac gtgtacctgg     3300

ataatggggt gtacaagttc gtgaccgtga agaacctgga cgtcattaag aaggaaaact     3360

actacgaagt gaactcaaag tgctacgagg aagccaagaa gctcaagaag atcagcaacc     3420

aggccgagtt catcgcatcg ttttacaaca atgacctcat taagattaat ggagaactgt     3480

acagagtgat cggcgtgaac aacgacctcc tgaaccggat tgaagtgaac atgatcgata     3540

ttacctaccg ggagtatctg gagaacatga acgacaagcg cccaccgaga atcatcaaaa     3600

ctattgcctc caagacccaa tccattaaga aatactccac cgacatcctg ggcaacctgt     3660

acgaggtcaa gtcgaagaag cacccccaga ttatcaagaa gggaaaaagg ccggcggcca     3720

cgaaaaaggc cggccaggca aaaaagaaaa aggcttaaga attcctagag ctcgctgatc     3780

agcctcgaaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     3840

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     3900

atgtatctta tcatgtctgt ataccagcag gctttcctag gttcgaacgc tgacgtcatc     3960

aacccgctcc aaggaatcgc gggcccagtg tcactaggcg ggaacaccca gcgcgcgtgc     4020

gccctggcag gaagatggct gtgagggaca ggggagtggc gccctgcaat atttgcatgt     4080

cgctatgtgt tctgggaaat caccataaac gtgaaatccc tatcagtgat agagacttat     4140

aagttcccta tcagtgatag agacaccggg tgtggtacgc agccactgtt taagtactct     4200

gtgctggaaa cagcacagaa tctacttaaa caaggcaaaa tgccgtgttt atctcgtcaa     4260

cttgttggcg agattttttc acgtgcggac cgaggctgca gcgtcgtcct ccctaggaac     4320

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     4380

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     4440

gcagctgcct gcaggggcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt     4500

cacaccgcat acgtcaaagc aaccatagta cgcgccctgt agcggcgcat taagcgcggc     4560

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     4620

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     4680

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     4740

tgatttgggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     4800

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     4860

ccctatctcg ggctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     4920

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttac     4980

aattttatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     5040

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     5100

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     5160

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgaa     5220

caataaaact gtctgcttac ataaacagta atacaagggg tgttatgagc catattcaac     5280

gggaaacgtc gaggccgcga ttaaattcca acatggatgc tgatttatat gggtataaat     5340

gggctcgcga taatgtcggg caatcaggtg cgacaatcta tcgcttgtat gggaagcccg     5400

atgcgccaga gttgtttctg aaacatggca aaggtagcgt tgccaatgat gttacagatg     5460

agatggtcag actaaactgg ctgacggaat ttatgcctct tccgaccatc aagcatttta     5520

tccgtactcc tgatgatgca tggttactca ccactgcgat ccccggaaaa acagcattcc     5580

aggtattaga agaatatcct gattcaggtg aaaatattgt tgatgcgctg gcagtgttcc     5640

tgcgccggtt gcattcgatt cctgtttgta attgtccttt taacagcgat cgcgtatttc     5700

gtctcgctca ggcgcaatca cgaatgaata acggtttggt tgatgcgagt gattttgatg     5760

acgagcgtaa tggctggcct gttgaacaag tctggaaaga aatgcataaa cttttgccat     5820

tctcaccgga ttcagtcgtc actcatggtg atttctcact tgataacctt atttttgacg     5880

aggggaaatt aataggttgt attgatgttg gacgagtcgg aatcgcagac cgataccagg     5940

atcttgccat cctatggaac tgcctcggtg agttttctcc ttcattacag aaacggcttt     6000

ttcaaaaata tggtattgat aatcctgata tgaataaatt gcagtttcat ttgatgctcg     6060

atgagttttt ctaatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg     6120

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc     6180

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag     6240

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc     6300

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac     6360

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc     6420

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt     6480

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt     6540

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc     6600

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt     6660

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca     6720

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt     6780

tgctggcctt ttgctcacat gt                                              6802


<210>  8
<211>  6828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  8
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggatcca agcggaacta      420

tatcctggga ctggacatcg gaattacctc cgtgggatac ggcatcatcg attacgagac      480

tagggacgtg attgacgccg gcgtgagact ctttaaggag gccaacgtgg aaaacaacga      540

aggtcgcaga tccaagcggg gtgcaagacg cctgaagcgc cggaggagac atcggataca      600

gcgcgtgaag aagctccttt tcgactacaa cctcctcact gaccactcgg aattgtccgg      660

tatcaacccc tacgaagccc gcgtgaaagg cctgagccag aagctgtccg aagaggagtt      720

tagcgcagcc ctgctgcacc tggctaagcg aaggggggtg cacaacgtga acgaggtgga      780

ggaggacact ggcaacgaac tgtccaccaa ggagcagatt tcacggaact cgaaggcgct      840

ggaagagaaa tatgtggccg agctgcagct ggagaggctc aagaaggatg gcgaagtccg      900

ggggagcatc aatcgcttca agacctcgga ctacgtgaag gaagccaaac agctgttgaa      960

ggtgcagaag gcctaccacc aactggacca atcattcatt gacacttaca tcgatctgct     1020

tgaaaccagg cgcacctact acgagggtcc tggagaaggc agccctttcg gatggaagga     1080

catcaaggag tggtatgaga tgctgatggg tcattgcacc tactttccgg aagaactgcg     1140

ctcagtgaag tacgcgtaca acgctgacct ctacaacgct ctcaacgatc tgaacaacct     1200

cgtgatcacc cgggacgaga acgaaaagct ggagtactac gaaaagttcc agattatcga     1260

aaacgtgttc aagcagaaga agaagcccac cctgaagcag attgcaaagg agatccttgt     1320

gaacgaggag gatattaagg gctaccgggt cacctccacc gggaaaccag agttcactaa     1380

tctcaaggtg taccatgaca ttaaggacat tactgcccgc aaggagatca ttgaaaacgc     1440

ggaactgctg gaccaaatcg cgaagatcct gaccatctat cagagctccg aggatatcca     1500

ggaggaactt actaacctca attccgagct gacgcaggaa gaaatcgagc aaattagcaa     1560

cctgaagggt tacactggaa cccacaacct cagcttgaaa gcgattaacc ttattttgga     1620

tgaactttgg cacactaatg acaatcagat cgccattttc aaccggctga aactggtgcc     1680

gaagaaggtg gacctgagcc aacagaagga aatcccgacc acccttgtgg acgatttcat     1740

cctgtcacct gtggtgaaga ggagcttcat ccagtcgatc aaggtcatca acgccatcat     1800

aaagaagtac ggccttccca acgacatcat catcgaactg gcccgcgaga agaactccaa     1860

agatgcccag aagatgatca acgagatgca gaagcgaaac cggcagacga acgaacggat     1920

cgaggagatc atccggacca ccgggaagga aaacgcgaag tacctgatcg agaaaatcaa     1980

gctgcatgat atgcaggaag ggaagtgtct ctactccctg gaggccattc cgctggagga     2040

tttgctgaac aaccctttca actacgaagt cgatcatatc attcctcgct ccgtgtcctt     2100

cgataactcc ttcaacaata aggtcctcgt gaagcaggag gagaagtaag tatcaaggtt     2160

acaagacagg tttaaggaga ccaatagaaa ctgggctcga gcttgtcgag acagagaaga     2220

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc     2280

acagctcgaa gaagggcaac agaaccccgt tccagtacct ctcgtcgtcc gactccaaga     2340

tcagctacga aactttcaag aagcacattc tgaacctggc caagggcaaa gggagaatta     2400

gcaagaccaa gaaggaatac ctcctggaag agagagacat caaccgcttc tcggtgcaaa     2460

aggatttcat caaccgcaac ctggtcgata ccagatacgc caccagggga ctgatgaacc     2520

tcctgcggtc ctacttccgg gtcaacaatc tggacgtgaa ggtcaaatcc atcaacgggg     2580

gctttacttc tttcctgcgc cggaagtgga agttcaagaa ggaacggaac aagggataca     2640

agcaccacgc tgaagatgcc ctgattattg ccaacgccga cttcatcttt aaggaatgga     2700

aaaagctgga caaggctaag aaggtcatgg agaaccagat gttcgaagaa aagcaggccg     2760

agtccatgcc cgaaatcgaa accgagcagg aatacaagga gatcttcatc acaccgcacc     2820

aaatcaagca catcaaggac ttcaaggatt acaagtacag ccaccgggtg gacaagaagc     2880

ctaacagaga gcttatcaac gacaccctgt actccacgcg caaggacgac aagggaaaca     2940

cattgatcgt gaacaacctg aacggactgt atgacaagga caatgacaaa ctgaagaagc     3000

tgatcaacaa atcgccggaa aagctcctga tgtaccatca cgaccctcaa acctaccaga     3060

aactgaagct catcatggag cagtacggcg acgaaaagaa tcccctgtac aaatactacg     3120

aggagactgg aaattacctg actaagtact ccaagaagga taacggcccc gtgatcaaga     3180

agattaagta ctacggaaac aaactgaacg cacatctcga catcaccgat gattatccaa     3240

actcccgcaa caaagtcgtg aagctctccc tcaaaccgta ccgcttcgac gtgtacctgg     3300

ataatggggt gtacaagttc gtgaccgtga agaacctgga cgtcattaag aaggaaaact     3360

actacgaagt gaactcaaag tgctacgagg aagccaagaa gctcaagaag atcagcaacc     3420

aggccgagtt catcgcatcg ttttacaaca atgacctcat taagattaat ggagaactgt     3480

acagagtgat cggcgtgaac aacgacctcc tgaaccggat tgaagtgaac atgatcgata     3540

ttacctaccg ggagtatctg gagaacatga acgacaagcg cccaccgaga atcatcaaaa     3600

ctattgcctc caagacccaa tccattaaga aatactccac cgacatcctg ggcaacctgt     3660

acgaggtcaa gtcgaagaag cacccccaga ttatcaagaa gggaaaaagg ccggcggcca     3720

cgaaaaaggc cggccaggca aaaaagaaaa aggcttaaga attcctagag ctcgctgatc     3780

agcctcgaaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     3840

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     3900

atgtatctta tcatgtctgt ataccagcag gctttcctag gttcgagggc ctatttccca     3960

tgattccttc atatttgcat atacgataca aggctgttag agagataatt ggaattaatt     4020

tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa taatttcttg     4080

ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt accgtaactt     4140

gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac accgggtgtg     4200

gtacgcagcc actgtttaag tactctgtgc tggaaacagc acagaatcta cttaaacaag     4260

gcaaaatgcc gtgtttatct cgtcaacttg ttggcgagat tttttcacgt gcggaccgag     4320

gctgcagcgt cgtcctccct aggaacccct agtgatggag ttggccactc cctctctgcg     4380

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4440

ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag gggcgcctga tgcggtattt     4500

tctccttacg catctgtgcg gtatttcaca ccgcatacgt caaagcaacc atagtacgcg     4560

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4620

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4680

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     4740

ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg gttcacgtag tgggccatcg     4800

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     4860

ttgttccaaa ctggaacaac actcaaccct atctcgggct attcttttga tttataaggg     4920

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     4980

aattttaaca aaatattaac gtttacaatt ttatggtgca ctctcagtac aatctgctct     5040

gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg     5100

gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg     5160

tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc     5220

ctatttttat aggttaatgt catgaacaat aaaactgtct gcttacataa acagtaatac     5280

aaggggtgtt atgagccata ttcaacggga aacgtcgagg ccgcgattaa attccaacat     5340

ggatgctgat ttatatgggt ataaatgggc tcgcgataat gtcgggcaat caggtgcgac     5400

aatctatcgc ttgtatggga agcccgatgc gccagagttg tttctgaaac atggcaaagg     5460

tagcgttgcc aatgatgtta cagatgagat ggtcagacta aactggctga cggaatttat     5520

gcctcttccg accatcaagc attttatccg tactcctgat gatgcatggt tactcaccac     5580

tgcgatcccc ggaaaaacag cattccaggt attagaagaa tatcctgatt caggtgaaaa     5640

tattgttgat gcgctggcag tgttcctgcg ccggttgcat tcgattcctg tttgtaattg     5700

tccttttaac agcgatcgcg tatttcgtct cgctcaggcg caatcacgaa tgaataacgg     5760

tttggttgat gcgagtgatt ttgatgacga gcgtaatggc tggcctgttg aacaagtctg     5820

gaaagaaatg cataaacttt tgccattctc accggattca gtcgtcactc atggtgattt     5880

ctcacttgat aaccttattt ttgacgaggg gaaattaata ggttgtattg atgttggacg     5940

agtcggaatc gcagaccgat accaggatct tgccatccta tggaactgcc tcggtgagtt     6000

ttctccttca ttacagaaac ggctttttca aaaatatggt attgataatc ctgatatgaa     6060

taaattgcag tttcatttga tgctcgatga gtttttctaa tctcatgacc aaaatccctt     6120

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt     6180

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag     6240

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca     6300

gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca     6360

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg     6420

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg     6480

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct     6540

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     6600

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     6660

ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     6720

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     6780

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgt                  6828


<210>  9
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  9
ggaauuaccu ccgugggaua ccgaaguauc ccacggaggu aauuccuuuu uu               52


<210>  10
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  10
ggauauccag gaggaacuua ccgaaguaag uuccuccugg auauccuuuu uu               52


<210>  11
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  11
ggagcuucau ccagucgauc acgaaugauc gacuggauga agcuccuuuu uu               52


<210>  12
<211>  6785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  12
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg attacaaaga ccacgacgga gactacaagg atcacgacat      420

tgattacaag gatgatgatg ataaggcccc aaagaagaag cggaaggtcg gtatccacgg      480

agtcccagca gccggatccg ccatgaagcg gaactatatc ctgggactgg acatcggaat      540

tacctccgtg ggatacggca tcatcgatta cgagactagg gacgtgattg acgccggcgt      600

gagactcttt aaggaggcca acgtggaaaa caacgaaggt cgcagatcca agcggggtgc      660

aagacgcctg aagcgccgga ggagacatcg gatacagcgc gtgaagaagc tccttttcga      720

ctacaacctc ctcactgacc actcggaatt gtccggtatc aacccctacg aagcccgcgt      780

gaaaggcctg agccagaagc tgtccgaaga ggagtttagc gcagccctgc tgcacctggc      840

taagcgaagg ggggtgcaca acgtgaacga ggtggaggag gacactggca acgaactgtc      900

caccaaggag cagatttcac ggaactcgaa ggcgctggaa gagaaatatg tggccgagct      960

gcagctggag aggctcaaga aggatggcga agtccggggg agcatcaatc gcttcaagac     1020

ctcggactac gtgaaggaag ccaaacagct gttgaaggtg cagaaggcct accaccaact     1080

ggaccaatca ttcattgaca cttacatcga tctgcttgaa accaggcgca cctactacga     1140

gggtcctgga gaaggcagcc ctttcggatg gaaggacatc aaggagtggt atgagatgct     1200

gatgggtcat tgcacctact ttccggaaga actgcgctca gtgaagtacg cgtacaacgc     1260

tgacctctac aacgctctca acgatctgaa caacctcgtg atcacccggg acgagaacga     1320

aaagctggag tactacgaaa agttccagat tatcgaaaac gtgttcaagc agaagaagaa     1380

gcccaccctg aagcagattg caaaggagat ccttgtgaac gaggaggata ttaagggcta     1440

ccgggtcacc tccaccggga aaccagagtt cactaatctc aaggtgtacc atgacattaa     1500

ggacattact gcccgcaagg agatcattga aaacgcggaa ctgctggacc aaatcgcgaa     1560

gatcctgacc atctatcaga gctccgagga tatccaggag gaacttacta acctcaattc     1620

cgagctgacg caggaagaaa tcgagcaaat tagcaacctg aagggttaca ctggaaccca     1680

caacctcagc ttgaaagcga ttaaccttat tttggatgaa ctttggcaca ctaatgacaa     1740

tcagatcgcc attttcaacc ggctgaaact ggtgccgaag aaggtggacc tgagccaaca     1800

gaaggaaatc ccgaccaccc ttgtggacga tttcatcctg tcacctgtgg tgaagaggag     1860

cttcatccag tcgatcaagg tcatcaacgc catcataaag aagtacggcc ttcccaacga     1920

catcatcatc gaactggccc gcgagaagaa ctccaaagat gcccagaaga tgatcaacga     1980

gatgcagaag cgaaaccggc agacgaacga acggatcgag gagatcatcc ggaccaccgg     2040

gaaggaaaac gcgaagtacc tgatcgagaa aatcaagctg catgatatgc aggaagggaa     2100

gtgtctctac tccctggagg ccattccgct ggaggatttg ctgaacaacc ctttcaacta     2160

cgaagtcgat catatcattc ctcgctccgt gtccttcgat aactccttca acaataaggt     2220

cctcgtgaag caggaggaga actcgaagaa gggcaacaga accccgttcc agtacctctc     2280

gtcgtccgac tccaagatca gctacgaaac tttcaagaag cacattctga acctggccaa     2340

gggcaaaggg agaattagca agaccaagaa ggaatacctc ctggaagaga gagacatcaa     2400

ccgcttctcg gtgcaaaagg atttcatcaa ccgcaacctg gtcgatacca gatacgccac     2460

caggggactg atgaacctcc tgcggtccta cttccgggtc aacaatctgg acgtgaaggt     2520

caaatccatc aacgggggct ttacttcttt cctgcgccgg aagtggaagt tcaagaagga     2580

acggaacaag ggatacaagc accacgctga agatgccctg attattgcca acgccgactt     2640

catctttaag gaatggaaaa agctggacaa ggctaagaag gtcatggaga accagatgtt     2700

cgaagaaaag caggccgagt ccatgcccga aatcgaaacc gagcaggaat acaaggagat     2760

cttcatcaca ccgcaccaaa tcaagcacat caaggacttc aaggattaca agtacagcca     2820

ccgggtggac aagaagccta acagagagct tatcaacgac accctgtact ccacgcgcaa     2880

ggacgacaag ggaaacacat tgatcgtgaa caacctgaac ggactgtatg acaaggacaa     2940

tgacaaactg aagaagctga tcaacaaatc gccggaaaag ctcctgatgt accatcacga     3000

ccctcaaacc taccagaaac tgaagctcat catggagcag tacggcgacg aaaagaatcc     3060

cctgtacaaa tactacgagg agactggaaa ttacctgact aagtactcca agaaggataa     3120

cggccccgtg atcaagaaga ttaagtacta cggaaacaaa ctgaacgcac atctcgacat     3180

caccgatgat tatccaaact cccgcaacaa agtcgtgaag ctctccctca aaccgtaccg     3240

cttcgacgtg tacctggata atggggtgta caagttcgtg accgtgaaga acctggacgt     3300

cattaagaag gaaaactact acgaagtgaa ctcaaagtgc tacgaggaag ccaagaagct     3360

caagaagatc agcaaccagg ccgagttcat cgcatcgttt tacaacaatg acctcattaa     3420

gattaatgga gaactgtaca gagtgatcgg cgtgaacaac gacctcctga accggattga     3480

agtgaacatg atcgatatta cctaccggga gtatctggag aacatgaacg acaagcgccc     3540

accgagaatc atcaaaacta ttgcctccaa gacccaatcc attaagaaat actccaccga     3600

catcctgggc aacctgtacg aggtcaagtc gaagaagcac ccccagatta tcaagaaggg     3660

aaaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg cttaagaatt     3720

cctagagctc gctgatcagc ctcgaaactt gtttattgca gcttataatg gttacaaata     3780

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg     3840

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccagcaggct ttcctaggtt     3900

cgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga     3960

gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag     4020

aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca     4080

tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg     4140

acgaaacacc gggtgtggta cgcagccact gtttaagtac tctgtgctgg aaacagcaca     4200

gaatctactt aaacaaggca aaatgccgtg tttatctcgt caacttgttg gcgagatttt     4260

ttcacgtgcg gaccgaggct gcagcgtcgt cctccctagg aacccctagt gatggagttg     4320

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     4380

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcagggg     4440

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacgtcaa     4500

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     4560

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     4620

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     4680

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg ggtgatggtt     4740

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     4800

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcgggctatt     4860

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     4920

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta tggtgcactc     4980

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     5040

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     5100

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     5160

agggcctcgt gatacgccta tttttatagg ttaatgtcat gaacaataaa actgtctgct     5220

tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac gtcgaggccg     5280

cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg cgataatgtc     5340

gggcaatcag gtgcgacaat ctatcgcttg tatgggaagc ccgatgcgcc agagttgttt     5400

ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt cagactaaac     5460

tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac tcctgatgat     5520

gcatggttac tcaccactgc gatccccgga aaaacagcat tccaggtatt agaagaatat     5580

cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg     5640

attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa     5700

tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg taatggctgg     5760

cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc ggattcagtc     5820

gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa attaataggt     5880

tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc catcctatgg     5940

aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa atatggtatt     6000

gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt tttctaatct     6060

catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa     6120

gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa     6180

aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc     6240

gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta     6300

gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct     6360

gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg     6420

atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag     6480

cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc     6540

cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg     6600

agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt     6660

tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg     6720

gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca     6780

catgt                                                                 6785


<210>  13
<211>  6228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  13
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccggag acgacggcac gtctcatttt ttacccgatc      300

ccctatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagtatctgc      360

tccctgcttg tgtgttggag gtcgctgagt agtgcgcgag caaaatttaa gctacaacaa      420

ggcaaggctt gaccgacaat tgcatgaaga atctgcttag ggttaggcgt tttgcgctgc      480

ttcgcgatgt acgggccaga tatacgcgtt gacattgatt attgactagt tattaatagt      540

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      600

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      660

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      720

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      780

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      840

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt      900

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      960

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat     1020

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct     1080

atataagcag agctctctgg ctaactagag aacccactgc ttactggctt atcgttaatt     1140

aaccggtgcc accatgatgt cccgccttga taaatcaaaa gtaataaaca gtgctcttga     1200

gcttctcaat gaagttggta tagaagggtt gacgactcgg aaattggcgc aaaaactcgg     1260

tgttgagcag ccaaccttgt attggcatgt taaaaacaaa cgagcactcc tcgacgcttt     1320

ggcgatagag atgctggaca ggcaccacac gcatttctgt cccctcgaag gagagtcatg     1380

gcaggatttc cttagaaata acgcaaagtc cttcagatgt gcgctgctta gtcaccgcga     1440

cggcgcaaaa gttcatctcg gcactaggcc aaccgagaaa cagtacgaga ctctggagaa     1500

ccaactggcg tttttgtgtc aacagggttt tagtctcgaa aatgcgctct atgctctctc     1560

tgcggttggc catttcaccc tcggatgcgt actggaagat caggagcacc aagtggccaa     1620

agaagaacgg gaaacgccga ctacggacag catgcctccg ttgctccggc aagctataga     1680

gctcttcgat caccaaggcg ctgagccagc tttcttgttc ggattggaac ttattatatg     1740

cgggctcgaa aagcagctta aatgcgagtc aggttaagcg gccgctcgag tctagagggc     1800

ccgtttaaac ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt     1860

gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat     1920

aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg     1980

tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg     2040

tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctctaggggg tatccccacg     2100

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     2160

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     2220

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     2280

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     2340

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     2400

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     2460

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     2520

cgaattaatt ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc     2580

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc     2640

aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt     2700

cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc     2760

ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct     2820

attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg     2880

agcttgtata tccattttcg gatctgatca agagacagga tgaggatcgt ttcgcatgat     2940

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta     3000

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca     3060

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcagga     3120

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga     3180

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct     3240

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg     3300

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga     3360

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca     3420

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga     3480

ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg     3540

cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc     3600

gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt     3660

gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga     3720

gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc caacctgcca     3780

tcacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc     3840

cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac     3900

cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc     3960

acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta     4020

tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag     4080

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     4140

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     4200

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     4260

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     4320

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     4380

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     4440

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     4500

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     4560

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     4620

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     4680

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     4740

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     4800

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     4860

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     4920

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     4980

tgatccggca aacaaaccac cgctggtagc ggtttttttg tttgcaagca gcagattacg     5040

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     5100

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     5160

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     5220

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     5280

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     5340

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     5400

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     5460

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     5520

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     5580

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     5640

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     5700

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     5760

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     5820

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     5880

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     5940

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     6000

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     6060

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     6120

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     6180

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtc                  6228


<210>  14
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  14
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccggaa ttacctccgt gggataccga agtatcccac      300

ggaggtaatt ccttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  15
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  15
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccggat atccaggagg aacttaccga agtaagttcc      300

tcctggatat ccttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  16
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  16
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccggag cttcatccag tcgatcacga atgatcgact      300

ggatgaagct ccttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  17
<211>  6904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  17
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgacg ggtgtggtac gcagccactg tttaagtact ctgtgctgga aacagcacag     4320

aatctactta aacaaggcaa aatgccgtgt ttatctcgtc aacttgttgg cgagattttt     4380

tcacgtgcgg accgaggctg cagcgtcgtc ctccctagga acccctagtg atggagttgg     4440

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     4500

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcaggggc     4560

gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atacgtcaaa     4620

gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4680

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4740

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4800

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgatttgg gtgatggttc     4860

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     4920

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cgggctattc     4980

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     5040

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaattttat ggtgcactct     5100

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc     5160

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     5220

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa     5280

gggcctcgtg atacgcctat ttttataggt taatgtcatg aacaataaaa ctgtctgctt     5340

acataaacag taatacaagg ggtgttatga gccatattca acgggaaacg tcgaggccgc     5400

gattaaattc caacatggat gctgatttat atgggtataa atgggctcgc gataatgtcg     5460

ggcaatcagg tgcgacaatc tatcgcttgt atgggaagcc cgatgcgcca gagttgtttc     5520

tgaaacatgg caaaggtagc gttgccaatg atgttacaga tgagatggtc agactaaact     5580

ggctgacgga atttatgcct cttccgacca tcaagcattt tatccgtact cctgatgatg     5640

catggttact caccactgcg atccccggaa aaacagcatt ccaggtatta gaagaatatc     5700

ctgattcagg tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga     5760

ttcctgtttg taattgtcct tttaacagcg atcgcgtatt tcgtctcgct caggcgcaat     5820

cacgaatgaa taacggtttg gttgatgcga gtgattttga tgacgagcgt aatggctggc     5880

ctgttgaaca agtctggaaa gaaatgcata aacttttgcc attctcaccg gattcagtcg     5940

tcactcatgg tgatttctca cttgataacc ttatttttga cgaggggaaa ttaataggtt     6000

gtattgatgt tggacgagtc ggaatcgcag accgatacca ggatcttgcc atcctatgga     6060

actgcctcgg tgagttttct ccttcattac agaaacggct ttttcaaaaa tatggtattg     6120

ataatcctga tatgaataaa ttgcagtttc atttgatgct cgatgagttt ttctaatctc     6180

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     6240

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     6300

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     6360

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     6420

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     6480

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     6540

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     6600

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     6660

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     6720

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     6780

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     6840

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     6900

atgt                                                                  6904


<210>  18
<211>  8452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  18
ctagctaact accggtgcca ccatggcccc aaagaagaag cggaaggtcg gtagtactgt       60

gggtactcga agtggctgcg taccacaccc gtcgcatgga tccaagcgga actatatcct      120

gggactggac atcggaatta cctccgtggg atacggcatc atcgattacg agactaggga      180

cgtgattgac gccggcgtga gactctttaa ggaggccaac gtggaaaaca acgaaggtcg      240

cagatccaag cggggtgcaa gacgcctgaa gcgccggagg agacatcgga tacagcgcgt      300

gaagaagctc cttttcgact acaacctcct cactgaccac tcggaattgt ccggtatcaa      360

cccctacgaa gcccgcgtga aaggcctgag ccagaagctg tccgaagagg agtttagcgc      420

agccctgctg cacctggcta agcgaagggg ggtgcacaac gtgaacgagg tggaggagga      480

cactggcaac gaactgtcca ccaaggagca gatttcacgg aactcgaagg cgctggaaga      540

gaaatatgtg gccgagctgc agctggagag gctcaagaag gatggcgaag tccgggggag      600

catcaatcgc ttcaagacct cggactacgt gaaggaagcc aaacagctgt tgaaggtgca      660

gaaggcctac caccaactgg accaatcatt cattgacact tacatcgatc tgcttgaaac      720

caggcgcacc tactacgagg gtcctggaga aggcagccct ttcggatgga aggacatcaa      780

ggagtggtat gagatgctga tgggtcattg cacctacttt ccggaagaac tgcgctcagt      840

gaagtacgcg tacaacgctg acctctacaa cgctctcaac gatctgaaca acctcgtgat      900

cacccgggac gagaacgaaa agctggagta ctacgaaaag ttccagatta tcgaaaacgt      960

gttcaagcag aagaagaagc ccaccctgaa gcagattgca aaggagatcc ttgtgaacga     1020

ggaggatatt aagggctacc gggtcacctc caccgggaaa ccagagttca ctaatctcaa     1080

ggtgtaccat gacattaagg acattactgc ccgcaaggag atcattgaaa acgcggaact     1140

gctggaccaa atcgcgaaga tcctgaccat ctatcagagc tccgaggata tccaggagga     1200

acttactaac ctcaattccg agctgacgca ggaagaaatc gagcaaatta gcaacctgaa     1260

gggttacact ggaacccaca acctcagctt gaaagcgatt aaccttattt tggatgaact     1320

ttggcacact aatgacaatc agatcgccat tttcaaccgg ctgaaactgg tgccgaagaa     1380

ggtggacctg agccaacaga aggaaatccc gaccaccctt gtggacgatt tcatcctgtc     1440

acctgtggtg aagaggagct tcatccagtc gatcaaggtc atcaacgcca tcataaagaa     1500

gtacggcctt cccaacgaca tcatcatcga actggcccgc gagaagaact ccaaagatgc     1560

ccagaagatg atcaacgaga tgcagaagcg aaaccggcag acgaacgaac ggatcgagga     1620

gatcatccgg accaccggga aggaaaacgc gaagtacctg atcgagaaaa tcaagctgca     1680

tgatatgcag gaagggaagt gtctctactc cctggaggcc attccgctgg aggatttgct     1740

gaacaaccct ttcaactacg aagtcgatca tatcattcct cgctccgtgt ccttcgataa     1800

ctccttcaac aataaggtcc tcgtgaagca ggaggagaag taagtatcaa ggttacaaga     1860

caggtttaag gagaccaata gaaactgggc tcgagaatgc gacgggtgtg gtacgcagcc     1920

acttcgagta cccacagtac tacctgcttg tcgagacaga gaagactctt gcgtttctga     1980

taggcaccta ttggtcttac tgacatccac tttgcctttc tctccacagc tcgaagaagg     2040

gcaacagaac cccgttccag tacctctcgt cgtccgactc caagatcagc tacgaaactt     2100

tcaagaagca cattctgaac ctggccaagg gcaaagggag aattagcaag accaagaagg     2160

aatacctcct ggaagagaga gacatcaacc gcttctcggt gcaaaaggat ttcatcaacc     2220

gcaacctggt cgataccaga tacgccacca ggggactgat gaacctcctg cggtcctact     2280

tccgggtcaa caatctggac gtgaaggtca aatccatcaa cgggggcttt acttctttcc     2340

tgcgccggaa gtggaagttc aagaaggaac ggaacaaggg atacaagcac cacgctgaag     2400

atgccctgat tattgccaac gccgacttca tctttaagga atggaaaaag ctggacaagg     2460

ctaagaaggt catggagaac cagatgttcg aagaaaagca ggccgagtcc atgcccgaaa     2520

tcgaaaccga gcaggaatac aaggagatct tcatcacacc gcaccaaatc aagcacatca     2580

aggacttcaa ggattacaag tacagccacc gggtggacaa gaagcctaac agagagctta     2640

tcaacgacac cctgtactcc acgcgcaagg acgacaaggg aaacacattg atcgtgaaca     2700

acctgaacgg actgtatgac aaggacaatg acaaactgaa gaagctgatc aacaaatcgc     2760

cggaaaagct cctgatgtac catcacgacc ctcaaaccta ccagaaactg aagctcatca     2820

tggagcagta cggcgacgaa aagaatcccc tgtacaaata ctacgaggag actggaaatt     2880

acctgactaa gtactccaag aaggataacg gccccgtgat caagaagatt aagtactacg     2940

gaaacaaact gaacgcacat ctcgacatca ccgatgatta tccaaactcc cgcaacaaag     3000

tcgtgaagct ctccctcaaa ccgtaccgct tcgacgtgta cctggataat ggggtgtaca     3060

agttcgtgac cgtgaagaac ctggacgtca ttaagaagga aaactactac gaagtgaact     3120

caaagtgcta cgaggaagcc aagaagctca agaagatcag caaccaggcc gagttcatcg     3180

catcgtttta caacaatgac ctcattaaga ttaatggaga actgtacaga gtgatcggcg     3240

tgaacaacga cctcctgaac cggattgaag tgaacatgat cgatattacc taccgggagt     3300

atctggagaa catgaacgac aagcgcccac cgagaatcat caaaactatt gcctccaaga     3360

cccaatccat taagaaatac tccaccgaca tcctgggcaa cctgtacgag gtcaagtcga     3420

agaagcaccc ccagattatc aagaagggaa aaaggccggc ggccacgaaa aaggccggcc     3480

aggcaaaaaa gaaaaaggct taagaattcc tagagctcgc tgatcagcct cgaaacttgt     3540

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag     3600

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     3660

tctgtatacc agcaggcttt cctaggttcg aacgctgacg tcatcaaccc gctccaagga     3720

atcgcgggcc cagtgtcact aggcgggaac acccagcgcg cgtgcgccct ggcaggaaga     3780

tggctgtgag ggacagggga gtggcgccct gcaatatttg catgtcgcta tgtgttctgg     3840

gaaatcacca taaacgtgaa atccctatca gtgatagaga cttataagtt ccctatcagt     3900

gatagagaca ccgacgggtg tggtacgcag ccactgttta agtactctgt gctggaaaca     3960

gcacagaatc tacttaaaca aggcaaaatg ccgtgtttat ctcgtcaact tgttggcgag     4020

attttttcac gtgcggaccg aggctgcagc gtcgtcctcc ctaggaaccc ctagtgatgg     4080

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     4140

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc     4200

aggggcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatac     4260

gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     4320

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     4380

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     4440

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg atttgggtga     4500

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     4560

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggg     4620

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     4680

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgttgacat tgattattga     4740

ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc     4800

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat     4860

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc     4920

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc     4980

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt     5040

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta     5100

ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg     5160

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac     5220

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg     5280

tacggtggga ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact     5340

ggcttatcgt taattaaccg gtgccaccat gatgtcccgc cttgataaat caaaagtaat     5400

aaacagtgct cttgagcttc tcaatgaagt tggtatagaa gggttgacga ctcggaaatt     5460

ggcgcaaaaa ctcggtgttg agcagccaac cttgtattgg catgttaaaa acaaacgagc     5520

actcctcgac gctttggcga tagagatgct ggacaggcac cacacgcatt tctgtcccct     5580

cgaaggagag tcatggcagg atttccttag aaataacgca aagtccttca gatgtgcgct     5640

gcttagtcac cgcgacggcg caaaagttca tctcggcact aggccaaccg agaaacagta     5700

cgagactctg gagaaccaac tggcgttttt gtgtcaacag ggttttagtc tcgaaaatgc     5760

gctctatgct ctctctgcgg ttggccattt caccctcgga tgcgtactgg aagatcagga     5820

gcaccaagtg gccaaagaag aacgggaaac gccgactacg gacagcatgc ctccgttgct     5880

ccggcaagct atagagctct tcgatcacca aggcgctgag ccagctttct tgttcggatt     5940

ggaacttatt atatgcgggc tcgaaaagca gcttaaatgc gagtcaggtt aagcggccgc     6000

tcgagtctag agggcccgtt taaacccgct gatcagcctc gactgtgcct tctagttgcc     6060

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     6120

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     6180

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     6240

atgctgggga tgcggtgggc tctatggaac gtttacaatt ttatggtgca ctctcagtac     6300

aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc     6360

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg     6420

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct     6480

cgtgatacgc ctatttttat aggttaatgt catgaacaat aaaactgtct gcttacataa     6540

acagtaatac aaggggtgtt atgagccata ttcaacggga aacgtcgagg ccgcgattaa     6600

attccaacat ggatgctgat ttatatgggt ataaatgggc tcgcgataat gtcgggcaat     6660

caggtgcgac aatctatcgc ttgtatggga agcccgatgc gccagagttg tttctgaaac     6720

atggcaaagg tagcgttgcc aatgatgtta cagatgagat ggtcagacta aactggctga     6780

cggaatttat gcctcttccg accatcaagc attttatccg tactcctgat gatgcatggt     6840

tactcaccac tgcgatcccc ggaaaaacag cattccaggt attagaagaa tatcctgatt     6900

caggtgaaaa tattgttgat gcgctggcag tgttcctgcg ccggttgcat tcgattcctg     6960

tttgtaattg tccttttaac agcgatcgcg tatttcgtct cgctcaggcg caatcacgaa     7020

tgaataacgg tttggttgat gcgagtgatt ttgatgacga gcgtaatggc tggcctgttg     7080

aacaagtctg gaaagaaatg cataaacttt tgccattctc accggattca gtcgtcactc     7140

atggtgattt ctcacttgat aaccttattt ttgacgaggg gaaattaata ggttgtattg     7200

atgttggacg agtcggaatc gcagaccgat accaggatct tgccatccta tggaactgcc     7260

tcggtgagtt ttctccttca ttacagaaac ggctttttca aaaatatggt attgataatc     7320

ctgatatgaa taaattgcag tttcatttga tgctcgatga gtttttctaa tctcatgacc     7380

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     7440

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     7500

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     7560

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     7620

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     7680

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     7740

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     7800

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     7860

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     7920

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     7980

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     8040

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgtcc     8100

tgcaggcagc tgcgcgctcg ctcgctcact gaggccgccc gggcgtcggg cgacctttgg     8160

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag     8220

gggttcctgc ggccgcacgc gtgctccggt gcccgtcagt gggcagagcg cacatcgccc     8280

acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg     8340

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     8400

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cg             8452


<210>  19
<211>  6987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  19
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggtctcccag gggcttccca      360

gtggtcccca ggaaccctcg acagggcccg gtctctctcg tccagcaagg gcagggacgg      420

gccacaggcc aagggcgcta gctaactacc ggtgccacca tggccccaaa gaagaagcgg      480

aaggtcggta gtactgtggg tactcgaagt ggctgcgtac cacacccgtc gcatggatcc      540

aagcggaact atatcctggg actggacatc ggaattacct ccgtgggata cggcatcatc      600

gattacgaga ctagggacgt gattgacgcc ggcgtgagac tctttaagga ggccaacgtg      660

gaaaacaacg aaggtcgcag atccaagcgg ggtgcaagac gcctgaagcg ccggaggaga      720

catcggatac agcgcgtgaa gaagctcctt ttcgactaca acctcctcac tgaccactcg      780

gaattgtccg gtatcaaccc ctacgaagcc cgcgtgaaag gcctgagcca gaagctgtcc      840

gaagaggagt ttagcgcagc cctgctgcac ctggctaagc gaaggggggt gcacaacgtg      900

aacgaggtgg aggaggacac tggcaacgaa ctgtccacca aggagcagat ttcacggaac      960

tcgaaggcgc tggaagagaa atatgtggcc gagctgcagc tggagaggct caagaaggat     1020

ggcgaagtcc gggggagcat caatcgcttc aagacctcgg actacgtgaa ggaagccaaa     1080

cagctgttga aggtgcagaa ggcctaccac caactggacc aatcattcat tgacacttac     1140

atcgatctgc ttgaaaccag gcgcacctac tacgagggtc ctggagaagg cagccctttc     1200

ggatggaagg acatcaagga gtggtatgag atgctgatgg gtcattgcac ctactttccg     1260

gaagaactgc gctcagtgaa gtacgcgtac aacgctgacc tctacaacgc tctcaacgat     1320

ctgaacaacc tcgtgatcac ccgggacgag aacgaaaagc tggagtacta cgaaaagttc     1380

cagattatcg aaaacgtgtt caagcagaag aagaagccca ccctgaagca gattgcaaag     1440

gagatccttg tgaacgagga ggatattaag ggctaccggg tcacctccac cgggaaacca     1500

gagttcacta atctcaaggt gtaccatgac attaaggaca ttactgcccg caaggagatc     1560

attgaaaacg cggaactgct ggaccaaatc gcgaagatcc tgaccatcta tcagagctcc     1620

gaggatatcc aggaggaact tactaacctc aattccgagc tgacgcagga agaaatcgag     1680

caaattagca acctgaaggg ttacactgga acccacaacc tcagcttgaa agcgattaac     1740

cttattttgg atgaactttg gcacactaat gacaatcaga tcgccatttt caaccggctg     1800

aaactggtgc cgaagaaggt ggacctgagc caacagaagg aaatcccgac cacccttgtg     1860

gacgatttca tcctgtcacc tgtggtgaag aggagcttca tccagtcgat caaggtcatc     1920

aacgccatca taaagaagta cggccttccc aacgacatca tcatcgaact ggcccgcgag     1980

aagaactcca aagatgccca gaagatgatc aacgagatgc agaagcgaaa ccggcagacg     2040

aacgaacgga tcgaggagat catccggacc accgggaagg aaaacgcgaa gtacctgatc     2100

gagaaaatca agctgcatga tatgcaggaa gggaagtgtc tctactccct ggaggccatt     2160

ccgctggagg atttgctgaa caaccctttc aactacgaag tcgatcatat cattcctcgc     2220

tccgtgtcct tcgataactc cttcaacaat aaggtcctcg tgaagcagga ggagaagtaa     2280

gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggctcg agaatgcgac     2340

gggtgtggta cgcagccact tcgagtaccc acagtactac ctgcttgtcg agacagagaa     2400

gactcttgcg tttctgatag gcacctattg gtcttactga catccacttt gcctttctct     2460

ccacagctcg aagaagggca acagaacccc gttccagtac ctctcgtcgt ccgactccaa     2520

gatcagctac gaaactttca agaagcacat tctgaacctg gccaagggca aagggagaat     2580

tagcaagacc aagaaggaat acctcctgga agagagagac atcaaccgct tctcggtgca     2640

aaaggatttc atcaaccgca acctggtcga taccagatac gccaccaggg gactgatgaa     2700

cctcctgcgg tcctacttcc gggtcaacaa tctggacgtg aaggtcaaat ccatcaacgg     2760

gggctttact tctttcctgc gccggaagtg gaagttcaag aaggaacgga acaagggata     2820

caagcaccac gctgaagatg ccctgattat tgccaacgcc gacttcatct ttaaggaatg     2880

gaaaaagctg gacaaggcta agaaggtcat ggagaaccag atgttcgaag aaaagcaggc     2940

cgagtccatg cccgaaatcg aaaccgagca ggaatacaag gagatcttca tcacaccgca     3000

ccaaatcaag cacatcaagg acttcaagga ttacaagtac agccaccggg tggacaagaa     3060

gcctaacaga gagcttatca acgacaccct gtactccacg cgcaaggacg acaagggaaa     3120

cacattgatc gtgaacaacc tgaacggact gtatgacaag gacaatgaca aactgaagaa     3180

gctgatcaac aaatcgccgg aaaagctcct gatgtaccat cacgaccctc aaacctacca     3240

gaaactgaag ctcatcatgg agcagtacgg cgacgaaaag aatcccctgt acaaatacta     3300

cgaggagact ggaaattacc tgactaagta ctccaagaag gataacggcc ccgtgatcaa     3360

gaagattaag tactacggaa acaaactgaa cgcacatctc gacatcaccg atgattatcc     3420

aaactcccgc aacaaagtcg tgaagctctc cctcaaaccg taccgcttcg acgtgtacct     3480

ggataatggg gtgtacaagt tcgtgaccgt gaagaacctg gacgtcatta agaaggaaaa     3540

ctactacgaa gtgaactcaa agtgctacga ggaagccaag aagctcaaga agatcagcaa     3600

ccaggccgag ttcatcgcat cgttttacaa caatgacctc attaagatta atggagaact     3660

gtacagagtg atcggcgtga acaacgacct cctgaaccgg attgaagtga acatgatcga     3720

tattacctac cgggagtatc tggagaacat gaacgacaag cgcccaccga gaatcatcaa     3780

aactattgcc tccaagaccc aatccattaa gaaatactcc accgacatcc tgggcaacct     3840

gtacgaggtc aagtcgaaga agcaccccca gattatcaag aagggaaaaa ggccggcggc     3900

cacgaaaaag gccggccagg caaaaaagaa aaaggcttaa gaattcctag agctcgctga     3960

tcagcctcga aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     4020

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     4080

caatgtatct tatcatgtct gtataccagc aggctttcct aggttcgaac gctgacgtca     4140

tcaacccgct ccaaggaatc gcgggcccag tgtcactagg cgggaacacc cagcgcgcgt     4200

gcgccctggc aggaagatgg ctgtgaggga caggggagtg gcgccctgca atatttgcat     4260

gtcgctatgt gttctgggaa atcaccataa acgtgaaatc cctatcagtg atagagactt     4320

ataagttccc tatcagtgat agagacaccg acgggtgtgg tacgcagcca ctgtttaagt     4380

actctgtgct ggaaacagca cagaatctac ttaaacaagg caaaatgccg tgtttatctc     4440

gtcaacttgt tggcgagatt ttttcacgtg cggaccgagg ctgcagcgtc gtcctcccta     4500

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4560

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     4620

agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg     4680

tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc     4740

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4800

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4860

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4920

aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4980

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     5040

ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     5100

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     5160

tttacaattt tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag     5220

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc     5280

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca     5340

tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     5400

atgaacaata aaactgtctg cttacataaa cagtaataca aggggtgtta tgagccatat     5460

tcaacgggaa acgtcgaggc cgcgattaaa ttccaacatg gatgctgatt tatatgggta     5520

taaatgggct cgcgataatg tcgggcaatc aggtgcgaca atctatcgct tgtatgggaa     5580

gcccgatgcg ccagagttgt ttctgaaaca tggcaaaggt agcgttgcca atgatgttac     5640

agatgagatg gtcagactaa actggctgac ggaatttatg cctcttccga ccatcaagca     5700

ttttatccgt actcctgatg atgcatggtt actcaccact gcgatccccg gaaaaacagc     5760

attccaggta ttagaagaat atcctgattc aggtgaaaat attgttgatg cgctggcagt     5820

gttcctgcgc cggttgcatt cgattcctgt ttgtaattgt ccttttaaca gcgatcgcgt     5880

atttcgtctc gctcaggcgc aatcacgaat gaataacggt ttggttgatg cgagtgattt     5940

tgatgacgag cgtaatggct ggcctgttga acaagtctgg aaagaaatgc ataaactttt     6000

gccattctca ccggattcag tcgtcactca tggtgatttc tcacttgata accttatttt     6060

tgacgagggg aaattaatag gttgtattga tgttggacga gtcggaatcg cagaccgata     6120

ccaggatctt gccatcctat ggaactgcct cggtgagttt tctccttcat tacagaaacg     6180

gctttttcaa aaatatggta ttgataatcc tgatatgaat aaattgcagt ttcatttgat     6240

gctcgatgag tttttctaat ctcatgacca aaatccctta acgtgagttt tcgttccact     6300

gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg     6360

taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc     6420

aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata     6480

ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta     6540

catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc     6600

ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg     6660

ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac     6720

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg     6780

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt     6840

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct     6900

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg     6960

ccttttgctg gccttttgct cacatgt                                         6987


<210>  20
<211>  8535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  20
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggtctcccag gggcttccca      360

gtggtcccca ggaaccctcg acagggcccg gtctctctcg tccagcaagg gcagggacgg      420

gccacaggcc aagggcgcta gctaactacc ggtgccacca tggccccaaa gaagaagcgg      480

aaggtcggta gtactgtggg tactcgaagt ggctgcgtac cacacccgtc gcatggatcc      540

aagcggaact atatcctggg actggacatc ggaattacct ccgtgggata cggcatcatc      600

gattacgaga ctagggacgt gattgacgcc ggcgtgagac tctttaagga ggccaacgtg      660

gaaaacaacg aaggtcgcag atccaagcgg ggtgcaagac gcctgaagcg ccggaggaga      720

catcggatac agcgcgtgaa gaagctcctt ttcgactaca acctcctcac tgaccactcg      780

gaattgtccg gtatcaaccc ctacgaagcc cgcgtgaaag gcctgagcca gaagctgtcc      840

gaagaggagt ttagcgcagc cctgctgcac ctggctaagc gaaggggggt gcacaacgtg      900

aacgaggtgg aggaggacac tggcaacgaa ctgtccacca aggagcagat ttcacggaac      960

tcgaaggcgc tggaagagaa atatgtggcc gagctgcagc tggagaggct caagaaggat     1020

ggcgaagtcc gggggagcat caatcgcttc aagacctcgg actacgtgaa ggaagccaaa     1080

cagctgttga aggtgcagaa ggcctaccac caactggacc aatcattcat tgacacttac     1140

atcgatctgc ttgaaaccag gcgcacctac tacgagggtc ctggagaagg cagccctttc     1200

ggatggaagg acatcaagga gtggtatgag atgctgatgg gtcattgcac ctactttccg     1260

gaagaactgc gctcagtgaa gtacgcgtac aacgctgacc tctacaacgc tctcaacgat     1320

ctgaacaacc tcgtgatcac ccgggacgag aacgaaaagc tggagtacta cgaaaagttc     1380

cagattatcg aaaacgtgtt caagcagaag aagaagccca ccctgaagca gattgcaaag     1440

gagatccttg tgaacgagga ggatattaag ggctaccggg tcacctccac cgggaaacca     1500

gagttcacta atctcaaggt gtaccatgac attaaggaca ttactgcccg caaggagatc     1560

attgaaaacg cggaactgct ggaccaaatc gcgaagatcc tgaccatcta tcagagctcc     1620

gaggatatcc aggaggaact tactaacctc aattccgagc tgacgcagga agaaatcgag     1680

caaattagca acctgaaggg ttacactgga acccacaacc tcagcttgaa agcgattaac     1740

cttattttgg atgaactttg gcacactaat gacaatcaga tcgccatttt caaccggctg     1800

aaactggtgc cgaagaaggt ggacctgagc caacagaagg aaatcccgac cacccttgtg     1860

gacgatttca tcctgtcacc tgtggtgaag aggagcttca tccagtcgat caaggtcatc     1920

aacgccatca taaagaagta cggccttccc aacgacatca tcatcgaact ggcccgcgag     1980

aagaactcca aagatgccca gaagatgatc aacgagatgc agaagcgaaa ccggcagacg     2040

aacgaacgga tcgaggagat catccggacc accgggaagg aaaacgcgaa gtacctgatc     2100

gagaaaatca agctgcatga tatgcaggaa gggaagtgtc tctactccct ggaggccatt     2160

ccgctggagg atttgctgaa caaccctttc aactacgaag tcgatcatat cattcctcgc     2220

tccgtgtcct tcgataactc cttcaacaat aaggtcctcg tgaagcagga ggagaagtaa     2280

gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggctcg agaatgcgac     2340

gggtgtggta cgcagccact tcgagtaccc acagtactac ctgcttgtcg agacagagaa     2400

gactcttgcg tttctgatag gcacctattg gtcttactga catccacttt gcctttctct     2460

ccacagctcg aagaagggca acagaacccc gttccagtac ctctcgtcgt ccgactccaa     2520

gatcagctac gaaactttca agaagcacat tctgaacctg gccaagggca aagggagaat     2580

tagcaagacc aagaaggaat acctcctgga agagagagac atcaaccgct tctcggtgca     2640

aaaggatttc atcaaccgca acctggtcga taccagatac gccaccaggg gactgatgaa     2700

cctcctgcgg tcctacttcc gggtcaacaa tctggacgtg aaggtcaaat ccatcaacgg     2760

gggctttact tctttcctgc gccggaagtg gaagttcaag aaggaacgga acaagggata     2820

caagcaccac gctgaagatg ccctgattat tgccaacgcc gacttcatct ttaaggaatg     2880

gaaaaagctg gacaaggcta agaaggtcat ggagaaccag atgttcgaag aaaagcaggc     2940

cgagtccatg cccgaaatcg aaaccgagca ggaatacaag gagatcttca tcacaccgca     3000

ccaaatcaag cacatcaagg acttcaagga ttacaagtac agccaccggg tggacaagaa     3060

gcctaacaga gagcttatca acgacaccct gtactccacg cgcaaggacg acaagggaaa     3120

cacattgatc gtgaacaacc tgaacggact gtatgacaag gacaatgaca aactgaagaa     3180

gctgatcaac aaatcgccgg aaaagctcct gatgtaccat cacgaccctc aaacctacca     3240

gaaactgaag ctcatcatgg agcagtacgg cgacgaaaag aatcccctgt acaaatacta     3300

cgaggagact ggaaattacc tgactaagta ctccaagaag gataacggcc ccgtgatcaa     3360

gaagattaag tactacggaa acaaactgaa cgcacatctc gacatcaccg atgattatcc     3420

aaactcccgc aacaaagtcg tgaagctctc cctcaaaccg taccgcttcg acgtgtacct     3480

ggataatggg gtgtacaagt tcgtgaccgt gaagaacctg gacgtcatta agaaggaaaa     3540

ctactacgaa gtgaactcaa agtgctacga ggaagccaag aagctcaaga agatcagcaa     3600

ccaggccgag ttcatcgcat cgttttacaa caatgacctc attaagatta atggagaact     3660

gtacagagtg atcggcgtga acaacgacct cctgaaccgg attgaagtga acatgatcga     3720

tattacctac cgggagtatc tggagaacat gaacgacaag cgcccaccga gaatcatcaa     3780

aactattgcc tccaagaccc aatccattaa gaaatactcc accgacatcc tgggcaacct     3840

gtacgaggtc aagtcgaaga agcaccccca gattatcaag aagggaaaaa ggccggcggc     3900

cacgaaaaag gccggccagg caaaaaagaa aaaggcttaa gaattcctag agctcgctga     3960

tcagcctcga aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     4020

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     4080

caatgtatct tatcatgtct gtataccagc aggctttcct aggttcgaac gctgacgtca     4140

tcaacccgct ccaaggaatc gcgggcccag tgtcactagg cgggaacacc cagcgcgcgt     4200

gcgccctggc aggaagatgg ctgtgaggga caggggagtg gcgccctgca atatttgcat     4260

gtcgctatgt gttctgggaa atcaccataa acgtgaaatc cctatcagtg atagagactt     4320

ataagttccc tatcagtgat agagacaccg acgggtgtgg tacgcagcca ctgtttaagt     4380

actctgtgct ggaaacagca cagaatctac ttaaacaagg caaaatgccg tgtttatctc     4440

gtcaacttgt tggcgagatt ttttcacgtg cggaccgagg ctgcagcgtc gtcctcccta     4500

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4560

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     4620

agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg     4680

tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc     4740

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4800

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4860

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4920

aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4980

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     5040

ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     5100

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     5160

ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag     5220

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc     5280

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg     5340

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca     5400

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc     5460

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt     5520

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata     5580

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt     5640

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca     5700

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctctct ggctaactag     5760

agaacccact gcttactggc ttatcgttaa ttaaccggtg ccaccatgat gtcccgcctt     5820

gataaatcaa aagtaataaa cagtgctctt gagcttctca atgaagttgg tatagaaggg     5880

ttgacgactc ggaaattggc gcaaaaactc ggtgttgagc agccaacctt gtattggcat     5940

gttaaaaaca aacgagcact cctcgacgct ttggcgatag agatgctgga caggcaccac     6000

acgcatttct gtcccctcga aggagagtca tggcaggatt tccttagaaa taacgcaaag     6060

tccttcagat gtgcgctgct tagtcaccgc gacggcgcaa aagttcatct cggcactagg     6120

ccaaccgaga aacagtacga gactctggag aaccaactgg cgtttttgtg tcaacagggt     6180

tttagtctcg aaaatgcgct ctatgctctc tctgcggttg gccatttcac cctcggatgc     6240

gtactggaag atcaggagca ccaagtggcc aaagaagaac gggaaacgcc gactacggac     6300

agcatgcctc cgttgctccg gcaagctata gagctcttcg atcaccaagg cgctgagcca     6360

gctttcttgt tcggattgga acttattata tgcgggctcg aaaagcagct taaatgcgag     6420

tcaggttaag cggccgctcg agtctagagg gcccgtttaa acccgctgat cagcctcgac     6480

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     6540

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     6600

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     6660

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggaacgtt tacaatttta     6720

tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg     6780

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     6840

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     6900

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gaacaataaa     6960

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac     7020

gtcgaggccg cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg     7080

cgataatgtc gggcaatcag gtgcgacaat ctatcgcttg tatgggaagc ccgatgcgcc     7140

agagttgttt ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt     7200

cagactaaac tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac     7260

tcctgatgat gcatggttac tcaccactgc gatccccgga aaaacagcat tccaggtatt     7320

agaagaatat cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg     7380

gttgcattcg attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc     7440

tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg     7500

taatggctgg cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc     7560

ggattcagtc gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa     7620

attaataggt tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc     7680

catcctatgg aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa     7740

atatggtatt gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt     7800

tttctaatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     7860

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     7920

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     7980

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag     8040

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     8100

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     8160

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     8220

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     8280

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     8340

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     8400

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     8460

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     8520

cttttgctca catgt                                                      8535


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  21
ctagctaact accggtgcca cca                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  22
gaggtattcc ttcttggtct tgc                                               23


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  23
cccacagtcc ccgagaagtt g                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  24
accttcttgc cactcctaag c                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  25
cttctggctc aggcctttca c                                                 21


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  26
cctgatcgag aaaatcaagc tgc                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  27
gcaagaccaa gaaggaatac ctc                                               23


<210>  28
<211>  1654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inserted sequence

<400>  28
ggtagtggtg aagggcgagg ctccttgctg acctgtggag atgttgaaga gaatcccggc       60

ccaggtacca tgcgacgggt gtggtacgca gccacttcga gtacccacag tactgctagc      120

gtgtctaagg gcgaagagct gattaaggag aacatgcaca tgaagctgta catggagggc      180

accgtggaca accatcactt caagtgcaca tccgagggcg aaggcaagcc ctacgagggc      240

acccagacca tgagaatcaa ggtggtcgag ggcggccctc tccccttcgc cttcgacatc      300

ctggctacta gcttcctcta cggcagcaag accttcatca accacaccca gggcatcccc      360

gacttcttca agcagtcctt ccctgagggc ttcacatggg agagagtcac cacatacgaa      420

gacgggggcg tgctgaccgc tacccaggac accagcctcc aggacggctg cctcatctac      480

aacgtcaaga tcagaggggt gaacttcaca tccaacggcc ctgtgatgca gaagaaaaca      540

ctcggctggg aggccttcac cgagacgctg taccccgctg acggcggcct ggaaggcaga      600

aacgacatgg ccctgaagct cgtgggcggg agccatctga tcgcaaacgc caagaccaca      660

tatagatcca agaaacccgc taagaacctc aagatgcctg gcgtctacta tgtggactac      720

agactggaaa gaatcaagga ggccaacaac gagacctacg tcgagcagca cgaggtggca      780

gtggccagat actgcgacct ccctagcaaa ctggggcaca aacttaataa gcttagccat      840

ggcttcccgc cggaggtgga ggagcaggat gatggcacgc tgcccatgtc ttgtgcccag      900

gagagcggga tggaccgtca ccctgcagcc tgtgcttctg ctaggatcaa tgtgcacccg      960

ggaagcgggg ctaccaactt cagtctcctc aaacaagctg gcgatgtgga ggaaaatcca     1020

ggtccggttc ctttgtctca agaagaatcc accctcattg aaagagcaac ggctacaatc     1080

aacagcatcc ccatctctga agactacagc gtcgccagcg cagctctctc tagcgacggc     1140

cgcatcttca ctggtgtcaa tgtatatcat tttactgggg gaccttgtgc agaactcgtg     1200

gtgctgggca ctgctgctgc tgcggcagct ggcaacctga cttgtatcgt cgcgatcgga     1260

aatgagaaca ggggcatctt gagcccctgc ggacggtgcc gacaggtgct tctcgatctg     1320

catcctggga tcaaagccat agtgaaggac agtgatggac agccgacggc agttgggatt     1380

cgtgaattgc tgccctctgg ttatgtgtgg gagggctaga gatctcgagc tgtgccttct     1440

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     1500

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     1560

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     1620

agcaggcatg ctggggatgc ggtgggctct atgg                                 1654


<210>  29
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TetR construct sequence

<400>  29
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag      600

aacccactgc ttactggctt atcgttaatt aaccggtgcc accatgatgt cccgccttga      660

taaatcaaaa gtaataaaca gtgctcttga gcttctcaat gaagttggta tagaagggtt      720

gacgactcgg aaattggcgc aaaaactcgg tgttgagcag ccaaccttgt attggcatgt      780

taaaaacaaa cgagcactcc tcgacgcttt ggcgatagag atgctggaca ggcaccacac      840

gcatttctgt cccctcgaag gagagtcatg gcaggatttc cttagaaata acgcaaagtc      900

cttcagatgt gcgctgctta gtcaccgcga cggcgcaaaa gttcatctcg gcactaggcc      960

aaccgagaaa cagtacgaga ctctggagaa ccaactggcg tttttgtgtc aacagggttt     1020

tagtctcgaa aatgcgctct atgctctctc tgcggttggc catttcaccc tcggatgcgt     1080

actggaagat caggagcacc aagtggccaa agaagaacgg gaaacgccga ctacggacag     1140

catgcctccg ttgctccggc aagctataga gctcttcgat caccaaggcg ctgagccagc     1200

tttcttgttc ggattggaac ttattatatg cgggctcgaa aagcagctta aatgcgagtc     1260

aggttaagcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca gcctcgactg     1320

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     1380

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     1440

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     1500

aagacaatag caggcatgct ggggatgcgg tgggctctat gg                        1542


<210>  30
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  30
gacgggugug guacgcagcc acu                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target DNA sequence

<400>  31
gacgggtgtg gtacgcagcc act                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of strand opposite target DNA

<400>  32
agtggctgcg taccacaccc gtc                                               23


<210>  33
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  33
ggguguggua cgcagccacu                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target DNA sequence

<400>  34
gggtgtggta cgcagccact                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of strand opposite target DNA

<400>  35
agtggctgcg taccacaccc                                                   20


<210>  36
<211>  8457
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  36
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggctagctaa ctaccggtgc      360

caccatggcc ccaaagaaga agcggaaggt cggtagtact gtgggtactc gaagtggctg      420

cgtaccacac ccgtcgcatg gatccaagcg gaactatatc ctgggactgg acatcggaat      480

tacctccgtg ggatacggca tcatcgatta cgagactagg gacgtgattg acgccggcgt      540

gagactcttt aaggaggcca acgtggaaaa caacgaaggt cgcagatcca agcggggtgc      600

aagacgcctg aagcgccgga ggagacatcg gatacagcgc gtgaagaagc tccttttcga      660

ctacaacctc ctcactgacc actcggaatt gtccggtatc aacccctacg aagcccgcgt      720

gaaaggcctg agccagaagc tgtccgaaga ggagtttagc gcagccctgc tgcacctggc      780

taagcgaagg ggggtgcaca acgtgaacga ggtggaggag gacactggca acgaactgtc      840

caccaaggag cagatttcac ggaactcgaa ggcgctggaa gagaaatatg tggccgagct      900

gcagctggag aggctcaaga aggatggcga agtccggggg agcatcaatc gcttcaagac      960

ctcggactac gtgaaggaag ccaaacagct gttgaaggtg cagaaggcct accaccaact     1020

ggaccaatca ttcattgaca cttacatcga tctgcttgaa accaggcgca cctactacga     1080

gggtcctgga gaaggcagcc ctttcggatg gaaggacatc aaggagtggt atgagatgct     1140

gatgggtcat tgcacctact ttccggaaga actgcgctca gtgaagtacg cgtacaacgc     1200

tgacctctac aacgctctca acgatctgaa caacctcgtg atcacccggg acgagaacga     1260

aaagctggag tactacgaaa agttccagat tatcgaaaac gtgttcaagc agaagaagaa     1320

gcccaccctg aagcagattg caaaggagat ccttgtgaac gaggaggata ttaagggcta     1380

ccgggtcacc tccaccggga aaccagagtt cactaatctc aaggtgtacc atgacattaa     1440

ggacattact gcccgcaagg agatcattga aaacgcggaa ctgctggacc aaatcgcgaa     1500

gatcctgacc atctatcaga gctccgagga tatccaggag gaacttacta acctcaattc     1560

cgagctgacg caggaagaaa tcgagcaaat tagcaacctg aagggttaca ctggaaccca     1620

caacctcagc ttgaaagcga ttaaccttat tttggatgaa ctttggcaca ctaatgacaa     1680

tcagatcgcc attttcaacc ggctgaaact ggtgccgaag aaggtggacc tgagccaaca     1740

gaaggaaatc ccgaccaccc ttgtggacga tttcatcctg tcacctgtgg tgaagaggag     1800

cttcatccag tcgatcaagg tcatcaacgc catcataaag aagtacggcc ttcccaacga     1860

catcatcatc gaactggccc gcgagaagaa ctccaaagat gcccagaaga tgatcaacga     1920

gatgcagaag cgaaaccggc agacgaacga acggatcgag gagatcatcc ggaccaccgg     1980

gaaggaaaac gcgaagtacc tgatcgagaa aatcaagctg catgatatgc aggaagggaa     2040

gtgtctctac tccctggagg ccattccgct ggaggatttg ctgaacaacc ctttcaacta     2100

cgaagtcgat catatcattc ctcgctccgt gtccttcgat aactccttca acaataaggt     2160

cctcgtgaag caggaggaga agtaagtatc aaggttacaa gacaggttta aggagaccaa     2220

tagaaactgg gctcgagaat gcgacgggtg tggtacgcag ccacttcgag tacccacagt     2280

actacctgct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     2340

actgacatcc actttgcctt tctctccaca gctcgaagaa gggcaacaga accccgttcc     2400

agtacctctc gtcgtccgac tccaagatca gctacgaaac tttcaagaag cacattctga     2460

acctggccaa gggcaaaggg agaattagca agaccaagaa ggaatacctc ctggaagaga     2520

gagacatcaa ccgcttctcg gtgcaaaagg atttcatcaa ccgcaacctg gtcgatacca     2580

gatacgccac caggggactg atgaacctcc tgcggtccta cttccgggtc aacaatctgg     2640

acgtgaaggt caaatccatc aacgggggct ttacttcttt cctgcgccgg aagtggaagt     2700

tcaagaagga acggaacaag ggatacaagc accacgctga agatgccctg attattgcca     2760

acgccgactt catctttaag gaatggaaaa agctggacaa ggctaagaag gtcatggaga     2820

accagatgtt cgaagaaaag caggccgagt ccatgcccga aatcgaaacc gagcaggaat     2880

acaaggagat cttcatcaca ccgcaccaaa tcaagcacat caaggacttc aaggattaca     2940

agtacagcca ccgggtggac aagaagccta acagagagct tatcaacgac accctgtact     3000

ccacgcgcaa ggacgacaag ggaaacacat tgatcgtgaa caacctgaac ggactgtatg     3060

acaaggacaa tgacaaactg aagaagctga tcaacaaatc gccggaaaag ctcctgatgt     3120

accatcacga ccctcaaacc taccagaaac tgaagctcat catggagcag tacggcgacg     3180

aaaagaatcc cctgtacaaa tactacgagg agactggaaa ttacctgact aagtactcca     3240

agaaggataa cggccccgtg atcaagaaga ttaagtacta cggaaacaaa ctgaacgcac     3300

atctcgacat caccgatgat tatccaaact cccgcaacaa agtcgtgaag ctctccctca     3360

aaccgtaccg cttcgacgtg tacctggata atggggtgta caagttcgtg accgtgaaga     3420

acctggacgt cattaagaag gaaaactact acgaagtgaa ctcaaagtgc tacgaggaag     3480

ccaagaagct caagaagatc agcaaccagg ccgagttcat cgcatcgttt tacaacaatg     3540

acctcattaa gattaatgga gaactgtaca gagtgatcgg cgtgaacaac gacctcctga     3600

accggattga agtgaacatg atcgatatta cctaccggga gtatctggag aacatgaacg     3660

acaagcgccc accgagaatc atcaaaacta ttgcctccaa gacccaatcc attaagaaat     3720

actccaccga catcctgggc aacctgtacg aggtcaagtc gaagaagcac ccccagatta     3780

tcaagaaggg aaaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg     3840

cttaagaatt cctagagctc gctgatcagc ctcgaaactt gtttattgca gcttataatg     3900

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     3960

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccagcaggct     4020

ttcctaggtt cgaacgctga cgtcatcaac ccgctccaag gaatcgcggg cccagtgtca     4080

ctaggcggga acacccagcg cgcgtgcgcc ctggcaggaa gatggctgtg agggacaggg     4140

gagtggcgcc ctgcaatatt tgcatgtcgc tatgtgttct gggaaatcac cataaacgtg     4200

aaatccctat cagtgataga gacttataag ttccctatca gtgatagaga caccgggtgt     4260

ggtacgcagc cactgtttaa gtactctgtg ctggaaacag cacagaatct acttaaacaa     4320

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga ttttttcacg tgcggaccga     4380

ggctgcagcg tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc     4440

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4500

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt     4560

ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc     4620

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     4680

acttgccagc gccttagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     4740

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     4800

tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc     4860

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     4920

cttgttccaa actggaacaa cactcaactc tatctcgggc tattcttttg atttataagg     4980

gattttgccg atttcggtct attggttaaa aaatgagctg atttaacaaa aatttaacgc     5040

gaattttaac aaaatattaa cgttagcgct gacattgatt attgactagt tattaatagt     5100

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta     5160

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga     5220

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt     5280

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta     5340

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg     5400

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt     5460

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc     5520

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat     5580

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct     5640

atataagcag agctctctgg ctaactagag aacccactgc ttactggctt atcgttaatt     5700

aaccggtgcc accatgatgt cccgccttga taaatcaaaa gtaataaaca gtgctcttga     5760

gcttctcaat gaagttggta tagaagggtt gacgactcgg aaattggcgc aaaaactcgg     5820

tgttgagcag ccaaccttgt attggcatgt taaaaacaaa cgagcactcc tcgacgcttt     5880

ggcgatagag atgctggaca ggcaccacac gcatttctgt cccctcgaag gagagtcatg     5940

gcaggatttc cttagaaata acgcaaagtc cttcagatgt gcgctgctta gtcaccgcga     6000

cggcgcaaaa gttcatctcg gcactaggcc aaccgagaaa cagtacgaga ctctggagaa     6060

ccaactggcg tttttgtgtc aacagggttt tagtctcgaa aatgcgctct atgctctctc     6120

tgcggttggc catttcaccc tcggatgcgt actggaagat caggagcacc aagtggccaa     6180

agaagaacgg gaaacgccga ctacggacag catgcctccg ttgctccggc aagctataga     6240

gctcttcgat caccaaggcg ctgagccagc tttcttgttc ggattggaac ttattatatg     6300

cgggctcgaa aagcagctta aatgcgagtc aggttaagtt taaacccgct gatcagcctc     6360

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     6420

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     6480

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     6540

ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgagttagt     6600

ccattgtcga cttccgagga ccgcggaacg tttacaattt tatggtgcac tctcagtaca     6660

atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg     6720

ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg     6780

agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc     6840

gtgatacgcc tatttttata ggttaatgtc atgaacaata aaactgtctg cttacataaa     6900

cagtaataca aggggtgtta tgagccatat tcaacgggaa acgtcgaggc cgcgattaaa     6960

ttccaacatg gatgctgatt tatatgggta taaatgggct cgcgataatg tcgggcaatc     7020

aggtgcgaca atctatcgct tgtatgggaa gcccgatgcg ccagagttgt ttctgaaaca     7080

tggcaaaggt agcgttgcca atgatgttac agatgagatg gtcagactaa actggctgac     7140

ggaatttatg cctcttccga ccatcaagca ttttatccgt actcctgatg atgcatggtt     7200

actcaccact gcgatccccg gaaaaacagc attccaggta ttagaagaat atcctgattc     7260

aggtgaaaat attgttgatg cgctggcagt gttcctgcgc cggttgcatt cgattcctgt     7320

ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctc gctcaggcgc aatcacgaat     7380

gaataacggt ttggttgatg cgagtgattt tgatgacgag cgtaatggct ggcctgttga     7440

acaagtctgg aaagaaatgc ataaactttt gccattctca ccggattcag tcgtcactca     7500

tggtgatttc tcacttgata accttatttt tgacgagggg aaattaatag gttgtattga     7560

tgttggacga gtcggaatcg cagaccgata ccaggatctt gccatcctat ggaactgcct     7620

cggtgagttt tctccttcat tacagaaacg gctttttcaa aaatatggta ttgataatcc     7680

tgatatgaat aaattgcagt ttcatttgat gctcgatgag tttttctaat ctcatgacca     7740

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7800

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7860

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7920

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7980

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     8040

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     8100

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     8160

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     8220

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     8280

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     8340

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     8400

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgt        8457


<210>  37
<211>  7230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  37
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggctagctaa ctaccggtgc      360

caccatggcc ccaaagaaga agcggaaggt cggtagtact gtgggtactc gaagtggctg      420

cgtaccacac ccgtcgcatg gatccaagcg gaactatatc ctgggactgg acatcggaat      480

tacctccgtg ggatacggca tcatcgatta cgagactagg gacgtgattg acgccggcgt      540

gagactcttt aaggaggcca acgtggaaaa caacgaaggt cgcagatcca agcggggtgc      600

aagacgcctg aagcgccgga ggagacatcg gatacagcgc gtgaagaagc tccttttcga      660

ctacaacctc ctcactgacc actcggaatt gtccggtatc aacccctacg aagcccgcgt      720

gaaaggcctg agccagaagc tgtccgaaga ggagtttagc gcagccctgc tgcacctggc      780

taagcgaagg ggggtgcaca acgtgaacga ggtggaggag gacactggca acgaactgtc      840

caccaaggag cagatttcac ggaactcgaa ggcgctggaa gagaaatatg tggccgagct      900

gcagctggag aggctcaaga aggatggcga agtccggggg agcatcaatc gcttcaagac      960

ctcggactac gtgaaggaag ccaaacagct gttgaaggtg cagaaggcct accaccaact     1020

ggaccaatca ttcattgaca cttacatcga tctgcttgaa accaggcgca cctactacga     1080

gggtcctgga gaaggcagcc ctttcggatg gaaggacatc aaggagtggt atgagatgct     1140

gatgggtcat tgcacctact ttccggaaga actgcgctca gtgaagtacg cgtacaacgc     1200

tgacctctac aacgctctca acgatctgaa caacctcgtg atcacccggg acgagaacga     1260

aaagctggag tactacgaaa agttccagat tatcgaaaac gtgttcaagc agaagaagaa     1320

gcccaccctg aagcagattg caaaggagat ccttgtgaac gaggaggata ttaagggcta     1380

ccgggtcacc tccaccggga aaccagagtt cactaatctc aaggtgtacc atgacattaa     1440

ggacattact gcccgcaagg agatcattga aaacgcggaa ctgctggacc aaatcgcgaa     1500

gatcctgacc atctatcaga gctccgagga tatccaggag gaacttacta acctcaattc     1560

cgagctgacg caggaagaaa tcgagcaaat tagcaacctg aagggttaca ctggaaccca     1620

caacctcagc ttgaaagcga ttaaccttat tttggatgaa ctttggcaca ctaatgacaa     1680

tcagatcgcc attttcaacc ggctgaaact ggtgccgaag aaggtggacc tgagccaaca     1740

gaaggaaatc ccgaccaccc ttgtggacga tttcatcctg tcacctgtgg tgaagaggag     1800

cttcatccag tcgatcaagg tcatcaacgc catcataaag aagtacggcc ttcccaacga     1860

catcatcatc gaactggccc gcgagaagaa ctccaaagat gcccagaaga tgatcaacga     1920

gatgcagaag cgaaaccggc agacgaacga acggatcgag gagatcatcc ggaccaccgg     1980

gaaggaaaac gcgaagtacc tgatcgagaa aatcaagctg catgatatgc aggaagggaa     2040

gtgtctctac tccctggagg ccattccgct ggaggatttg ctgaacaacc ctttcaacta     2100

cgaagtcgat catatcattc ctcgctccgt gtccttcgat aactccttca acaataaggt     2160

cctcgtgaag caggaggaga agtaagtatc aaggttacaa gacaggttta aggagaccaa     2220

tagaaactgg gctcgagaat gcgacgggtg tggtacgcag ccacttcgag tacccacagt     2280

actacctgct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     2340

actgacatcc actttgcctt tctctccaca gctcgaagaa gggcaacaga accccgttcc     2400

agtacctctc gtcgtccgac tccaagatca gctacgaaac tttcaagaag cacattctga     2460

acctggccaa gggcaaaggg agaattagca agaccaagaa ggaatacctc ctggaagaga     2520

gagacatcaa ccgcttctcg gtgcaaaagg atttcatcaa ccgcaacctg gtcgatacca     2580

gatacgccac caggggactg atgaacctcc tgcggtccta cttccgggtc aacaatctgg     2640

acgtgaaggt caaatccatc aacgggggct ttacttcttt cctgcgccgg aagtggaagt     2700

tcaagaagga acggaacaag ggatacaagc accacgctga agatgccctg attattgcca     2760

acgccgactt catctttaag gaatggaaaa agctggacaa ggctaagaag gtcatggaga     2820

accagatgtt cgaagaaaag caggccgagt ccatgcccga aatcgaaacc gagcaggaat     2880

acaaggagat cttcatcaca ccgcaccaaa tcaagcacat caaggacttc aaggattaca     2940

agtacagcca ccgggtggac aagaagccta acagagagct tatcaacgac accctgtact     3000

ccacgcgcaa ggacgacaag ggaaacacat tgatcgtgaa caacctgaac ggactgtatg     3060

acaaggacaa tgacaaactg aagaagctga tcaacaaatc gccggaaaag ctcctgatgt     3120

accatcacga ccctcaaacc taccagaaac tgaagctcat catggagcag tacggcgacg     3180

aaaagaatcc cctgtacaaa tactacgagg agactggaaa ttacctgact aagtactcca     3240

agaaggataa cggccccgtg atcaagaaga ttaagtacta cggaaacaaa ctgaacgcac     3300

atctcgacat caccgatgat tatccaaact cccgcaacaa agtcgtgaag ctctccctca     3360

aaccgtaccg cttcgacgtg tacctggata atggggtgta caagttcgtg accgtgaaga     3420

acctggacgt cattaagaag gaaaactact acgaagtgaa ctcaaagtgc tacgaggaag     3480

ccaagaagct caagaagatc agcaaccagg ccgagttcat cgcatcgttt tacaacaatg     3540

acctcattaa gattaatgga gaactgtaca gagtgatcgg cgtgaacaac gacctcctga     3600

accggattga agtgaacatg atcgatatta cctaccggga gtatctggag aacatgaacg     3660

acaagcgccc accgagaatc atcaaaacta ttgcctccaa gacccaatcc attaagaaat     3720

actccaccga catcctgggc aacctgtacg aggtcaagtc gaagaagcac ccccagatta     3780

tcaagaaggg aaaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg     3840

cttaagaatt cctagagctc gctgatcagc ctcgaaactt gtttattgca gcttataatg     3900

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     3960

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccagcaggct     4020

ttcctaggtt cgaacgctga cgtcatcaac ccgctccaag gaatcgcggg cccagtgtca     4080

ctaggcggga acacccagcg cgcgtgcgcc ctggcaggaa gatggctgtg agggacaggg     4140

gagtggcgcc ctgcaatatt tgcatgtcgc tatgtgttct gggaaatcac cataaacgtg     4200

aaatccctat cagtgataga gacttataag ttccctatca gtgatagaga caccgggtgt     4260

ggtacgcagc cactgtttaa gtactctgtg ctggaaacag cacagaatct acttaaacaa     4320

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga ttttttcacg tgcggaccga     4380

ggctgcagcg tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc     4440

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4500

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt     4560

ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc     4620

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     4680

acttgccagc gccttagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     4740

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     4800

tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc     4860

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     4920

cttgttccaa actggaacaa cactcaactc tatctcgggc tattcttttg atttataagg     4980

gattttgccg atttcggtct attggttaaa aaatgagctg atttaacaaa aatttaacgc     5040

gaattttaac aaaatattaa cgttagcgct tccattgtcg acttccgagg acgagggcct     5100

atttcccatg attccttcat atttgcatat acgatacaag gctgttagag agataattgg     5160

aattaatttg actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata     5220

atttcttggg tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac     5280

cgtaacttga aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac     5340

cggagcttca tccagtcgat cacgaatgat cgactggatg aagctccttt tttccgcgga     5400

acgtttacaa ttttatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     5460

cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca     5520

tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg     5580

tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat     5640

gtcatgaaca ataaaactgt ctgcttacat aaacagtaat acaaggggtg ttatgagcca     5700

tattcaacgg gaaacgtcga ggccgcgatt aaattccaac atggatgctg atttatatgg     5760

gtataaatgg gctcgcgata atgtcgggca atcaggtgcg acaatctatc gcttgtatgg     5820

gaagcccgat gcgccagagt tgtttctgaa acatggcaaa ggtagcgttg ccaatgatgt     5880

tacagatgag atggtcagac taaactggct gacggaattt atgcctcttc cgaccatcaa     5940

gcattttatc cgtactcctg atgatgcatg gttactcacc actgcgatcc ccggaaaaac     6000

agcattccag gtattagaag aatatcctga ttcaggtgaa aatattgttg atgcgctggc     6060

agtgttcctg cgccggttgc attcgattcc tgtttgtaat tgtcctttta acagcgatcg     6120

cgtatttcgt ctcgctcagg cgcaatcacg aatgaataac ggtttggttg atgcgagtga     6180

ttttgatgac gagcgtaatg gctggcctgt tgaacaagtc tggaaagaaa tgcataaact     6240

tttgccattc tcaccggatt cagtcgtcac tcatggtgat ttctcacttg ataaccttat     6300

ttttgacgag gggaaattaa taggttgtat tgatgttgga cgagtcggaa tcgcagaccg     6360

ataccaggat cttgccatcc tatggaactg cctcggtgag ttttctcctt cattacagaa     6420

acggcttttt caaaaatatg gtattgataa tcctgatatg aataaattgc agtttcattt     6480

gatgctcgat gagtttttct aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     6540

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     6600

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     6660

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     6720

atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     6780

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     6840

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     6900

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     6960

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     7020

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     7080

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     7140

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     7200

tggccttttg ctggcctttt gctcacatgt                                      7230


<210>  38
<211>  8759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  38
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggctagctaa ctaccggtgc      360

caccatggcc ccaaagaaga agcggaaggt cggtagtact gtgggtactc gaagtggctg      420

cgtaccacac ccgtcgcatg gatccaagcg gaactatatc ctgggactgg acatcggaat      480

tacctccgtg ggatacggca tcatcgatta cgagactagg gacgtgattg acgccggcgt      540

gagactcttt aaggaggcca acgtggaaaa caacgaaggt cgcagatcca agcggggtgc      600

aagacgcctg aagcgccgga ggagacatcg gatacagcgc gtgaagaagc tccttttcga      660

ctacaacctc ctcactgacc actcggaatt gtccggtatc aacccctacg aagcccgcgt      720

gaaaggcctg agccagaagc tgtccgaaga ggagtttagc gcagccctgc tgcacctggc      780

taagcgaagg ggggtgcaca acgtgaacga ggtggaggag gacactggca acgaactgtc      840

caccaaggag cagatttcac ggaactcgaa ggcgctggaa gagaaatatg tggccgagct      900

gcagctggag aggctcaaga aggatggcga agtccggggg agcatcaatc gcttcaagac      960

ctcggactac gtgaaggaag ccaaacagct gttgaaggtg cagaaggcct accaccaact     1020

ggaccaatca ttcattgaca cttacatcga tctgcttgaa accaggcgca cctactacga     1080

gggtcctgga gaaggcagcc ctttcggatg gaaggacatc aaggagtggt atgagatgct     1140

gatgggtcat tgcacctact ttccggaaga actgcgctca gtgaagtacg cgtacaacgc     1200

tgacctctac aacgctctca acgatctgaa caacctcgtg atcacccggg acgagaacga     1260

aaagctggag tactacgaaa agttccagat tatcgaaaac gtgttcaagc agaagaagaa     1320

gcccaccctg aagcagattg caaaggagat ccttgtgaac gaggaggata ttaagggcta     1380

ccgggtcacc tccaccggga aaccagagtt cactaatctc aaggtgtacc atgacattaa     1440

ggacattact gcccgcaagg agatcattga aaacgcggaa ctgctggacc aaatcgcgaa     1500

gatcctgacc atctatcaga gctccgagga tatccaggag gaacttacta acctcaattc     1560

cgagctgacg caggaagaaa tcgagcaaat tagcaacctg aagggttaca ctggaaccca     1620

caacctcagc ttgaaagcga ttaaccttat tttggatgaa ctttggcaca ctaatgacaa     1680

tcagatcgcc attttcaacc ggctgaaact ggtgccgaag aaggtggacc tgagccaaca     1740

gaaggaaatc ccgaccaccc ttgtggacga tttcatcctg tcacctgtgg tgaagaggag     1800

cttcatccag tcgatcaagg tcatcaacgc catcataaag aagtacggcc ttcccaacga     1860

catcatcatc gaactggccc gcgagaagaa ctccaaagat gcccagaaga tgatcaacga     1920

gatgcagaag cgaaaccggc agacgaacga acggatcgag gagatcatcc ggaccaccgg     1980

gaaggaaaac gcgaagtacc tgatcgagaa aatcaagctg catgatatgc aggaagggaa     2040

gtgtctctac tccctggagg ccattccgct ggaggatttg ctgaacaacc ctttcaacta     2100

cgaagtcgat catatcattc ctcgctccgt gtccttcgat aactccttca acaataaggt     2160

cctcgtgaag caggaggaga agtaagtatc aaggttacaa gacaggttta aggagaccaa     2220

tagaaactgg gctcgagaat gcgacgggtg tggtacgcag ccacttcgag tacccacagt     2280

actacctgct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     2340

actgacatcc actttgcctt tctctccaca gctcgaagaa gggcaacaga accccgttcc     2400

agtacctctc gtcgtccgac tccaagatca gctacgaaac tttcaagaag cacattctga     2460

acctggccaa gggcaaaggg agaattagca agaccaagaa ggaatacctc ctggaagaga     2520

gagacatcaa ccgcttctcg gtgcaaaagg atttcatcaa ccgcaacctg gtcgatacca     2580

gatacgccac caggggactg atgaacctcc tgcggtccta cttccgggtc aacaatctgg     2640

acgtgaaggt caaatccatc aacgggggct ttacttcttt cctgcgccgg aagtggaagt     2700

tcaagaagga acggaacaag ggatacaagc accacgctga agatgccctg attattgcca     2760

acgccgactt catctttaag gaatggaaaa agctggacaa ggctaagaag gtcatggaga     2820

accagatgtt cgaagaaaag caggccgagt ccatgcccga aatcgaaacc gagcaggaat     2880

acaaggagat cttcatcaca ccgcaccaaa tcaagcacat caaggacttc aaggattaca     2940

agtacagcca ccgggtggac aagaagccta acagagagct tatcaacgac accctgtact     3000

ccacgcgcaa ggacgacaag ggaaacacat tgatcgtgaa caacctgaac ggactgtatg     3060

acaaggacaa tgacaaactg aagaagctga tcaacaaatc gccggaaaag ctcctgatgt     3120

accatcacga ccctcaaacc taccagaaac tgaagctcat catggagcag tacggcgacg     3180

aaaagaatcc cctgtacaaa tactacgagg agactggaaa ttacctgact aagtactcca     3240

agaaggataa cggccccgtg atcaagaaga ttaagtacta cggaaacaaa ctgaacgcac     3300

atctcgacat caccgatgat tatccaaact cccgcaacaa agtcgtgaag ctctccctca     3360

aaccgtaccg cttcgacgtg tacctggata atggggtgta caagttcgtg accgtgaaga     3420

acctggacgt cattaagaag gaaaactact acgaagtgaa ctcaaagtgc tacgaggaag     3480

ccaagaagct caagaagatc agcaaccagg ccgagttcat cgcatcgttt tacaacaatg     3540

acctcattaa gattaatgga gaactgtaca gagtgatcgg cgtgaacaac gacctcctga     3600

accggattga agtgaacatg atcgatatta cctaccggga gtatctggag aacatgaacg     3660

acaagcgccc accgagaatc atcaaaacta ttgcctccaa gacccaatcc attaagaaat     3720

actccaccga catcctgggc aacctgtacg aggtcaagtc gaagaagcac ccccagatta     3780

tcaagaaggg aaaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg     3840

cttaagaatt cctagagctc gctgatcagc ctcgaaactt gtttattgca gcttataatg     3900

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     3960

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccagcaggct     4020

ttcctaggtt cgaacgctga cgtcatcaac ccgctccaag gaatcgcggg cccagtgtca     4080

ctaggcggga acacccagcg cgcgtgcgcc ctggcaggaa gatggctgtg agggacaggg     4140

gagtggcgcc ctgcaatatt tgcatgtcgc tatgtgttct gggaaatcac cataaacgtg     4200

aaatccctat cagtgataga gacttataag ttccctatca gtgatagaga caccgggtgt     4260

ggtacgcagc cactgtttaa gtactctgtg ctggaaacag cacagaatct acttaaacaa     4320

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga ttttttcacg tgcggaccga     4380

ggctgcagcg tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc     4440

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4500

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt     4560

ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc     4620

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     4680

acttgccagc gccttagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     4740

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     4800

tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc     4860

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     4920

cttgttccaa actggaacaa cactcaactc tatctcgggc tattcttttg atttataagg     4980

gattttgccg atttcggtct attggttaaa aaatgagctg atttaacaaa aatttaacgc     5040

gaattttaac aaaatattaa cgttagcgct gacattgatt attgactagt tattaatagt     5100

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta     5160

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga     5220

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt     5280

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta     5340

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg     5400

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt     5460

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc     5520

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat     5580

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct     5640

atataagcag agctctctgg ctaactagag aacccactgc ttactggctt atcgttaatt     5700

aaccggtgcc accatgatgt cccgccttga taaatcaaaa gtaataaaca gtgctcttga     5760

gcttctcaat gaagttggta tagaagggtt gacgactcgg aaattggcgc aaaaactcgg     5820

tgttgagcag ccaaccttgt attggcatgt taaaaacaaa cgagcactcc tcgacgcttt     5880

ggcgatagag atgctggaca ggcaccacac gcatttctgt cccctcgaag gagagtcatg     5940

gcaggatttc cttagaaata acgcaaagtc cttcagatgt gcgctgctta gtcaccgcga     6000

cggcgcaaaa gttcatctcg gcactaggcc aaccgagaaa cagtacgaga ctctggagaa     6060

ccaactggcg tttttgtgtc aacagggttt tagtctcgaa aatgcgctct atgctctctc     6120

tgcggttggc catttcaccc tcggatgcgt actggaagat caggagcacc aagtggccaa     6180

agaagaacgg gaaacgccga ctacggacag catgcctccg ttgctccggc aagctataga     6240

gctcttcgat caccaaggcg ctgagccagc tttcttgttc ggattggaac ttattatatg     6300

cgggctcgaa aagcagctta aatgcgagtc aggttaagtt taaacccgct gatcagcctc     6360

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     6420

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     6480

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     6540

ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgagttagt     6600

ccattgtcga cttccgagga cgagggccta tttcccatga ttccttcata tttgcatata     6660

cgatacaagg ctgttagaga gataattgga attaatttga ctgtaaacac aaagatatta     6720

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta     6780

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct     6840

ttatatatct tgtggaaagg acgaaacacc ggagcttcat ccagtcgatc acgaatgatc     6900

gactggatga agctcctttt ttccgcggaa cgtttacaat tttatggtgc actctcagta     6960

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg     7020

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg     7080

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc     7140

tcgtgatacg cctattttta taggttaatg tcatgaacaa taaaactgtc tgcttacata     7200

aacagtaata caaggggtgt tatgagccat attcaacggg aaacgtcgag gccgcgatta     7260

aattccaaca tggatgctga tttatatggg tataaatggg ctcgcgataa tgtcgggcaa     7320

tcaggtgcga caatctatcg cttgtatggg aagcccgatg cgccagagtt gtttctgaaa     7380

catggcaaag gtagcgttgc caatgatgtt acagatgaga tggtcagact aaactggctg     7440

acggaattta tgcctcttcc gaccatcaag cattttatcc gtactcctga tgatgcatgg     7500

ttactcacca ctgcgatccc cggaaaaaca gcattccagg tattagaaga atatcctgat     7560

tcaggtgaaa atattgttga tgcgctggca gtgttcctgc gccggttgca ttcgattcct     7620

gtttgtaatt gtccttttaa cagcgatcgc gtatttcgtc tcgctcaggc gcaatcacga     7680

atgaataacg gtttggttga tgcgagtgat tttgatgacg agcgtaatgg ctggcctgtt     7740

gaacaagtct ggaaagaaat gcataaactt ttgccattct caccggattc agtcgtcact     7800

catggtgatt tctcacttga taaccttatt tttgacgagg ggaaattaat aggttgtatt     7860

gatgttggac gagtcggaat cgcagaccga taccaggatc ttgccatcct atggaactgc     7920

ctcggtgagt tttctccttc attacagaaa cggctttttc aaaaatatgg tattgataat     7980

cctgatatga ataaattgca gtttcatttg atgctcgatg agtttttcta atctcatgac     8040

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     8100

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     8160

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     8220

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     8280

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     8340

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     8400

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     8460

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     8520

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     8580

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     8640

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     8700

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgt      8759


<210>  39
<211>  6889
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  39
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggctagctaa ctaccggtgc      360

caccatggcc ccaaagaaga agcggaaggt cggtagtact gtgggtactc gaagtggctg      420

cgtaccacac ccgtcgcatg gatccaagcg gaactatatc ctgggactgg acatcggaat      480

tacctccgtg ggatacggca tcatcgatta cgagactagg gacgtgattg acgccggcgt      540

gagactcttt aaggaggcca acgtggaaaa caacgaaggt cgcagatcca agcggggtgc      600

aagacgcctg aagcgccgga ggagacatcg gatacagcgc gtgaagaagc tccttttcga      660

ctacaacctc ctcactgacc actcggaatt gtccggtatc aacccctacg aagcccgcgt      720

gaaaggcctg agccagaagc tgtccgaaga ggagtttagc gcagccctgc tgcacctggc      780

taagcgaagg ggggtgcaca acgtgaacga ggtggaggag gacactggca acgaactgtc      840

caccaaggag cagatttcac ggaactcgaa ggcgctggaa gagaaatatg tggccgagct      900

gcagctggag aggctcaaga aggatggcga agtccggggg agcatcaatc gcttcaagac      960

ctcggactac gtgaaggaag ccaaacagct gttgaaggtg cagaaggcct accaccaact     1020

ggaccaatca ttcattgaca cttacatcga tctgcttgaa accaggcgca cctactacga     1080

gggtcctgga gaaggcagcc ctttcggatg gaaggacatc aaggagtggt atgagatgct     1140

gatgggtcat tgcacctact ttccggaaga actgcgctca gtgaagtacg cgtacaacgc     1200

tgacctctac aacgctctca acgatctgaa caacctcgtg atcacccggg acgagaacga     1260

aaagctggag tactacgaaa agttccagat tatcgaaaac gtgttcaagc agaagaagaa     1320

gcccaccctg aagcagattg caaaggagat ccttgtgaac gaggaggata ttaagggcta     1380

ccgggtcacc tccaccggga aaccagagtt cactaatctc aaggtgtacc atgacattaa     1440

ggacattact gcccgcaagg agatcattga aaacgcggaa ctgctggacc aaatcgcgaa     1500

gatcctgacc atctatcaga gctccgagga tatccaggag gaacttacta acctcaattc     1560

cgagctgacg caggaagaaa tcgagcaaat tagcaacctg aagggttaca ctggaaccca     1620

caacctcagc ttgaaagcga ttaaccttat tttggatgaa ctttggcaca ctaatgacaa     1680

tcagatcgcc attttcaacc ggctgaaact ggtgccgaag aaggtggacc tgagccaaca     1740

gaaggaaatc ccgaccaccc ttgtggacga tttcatcctg tcacctgtgg tgaagaggag     1800

cttcatccag tcgatcaagg tcatcaacgc catcataaag aagtacggcc ttcccaacga     1860

catcatcatc gaactggccc gcgagaagaa ctccaaagat gcccagaaga tgatcaacga     1920

gatgcagaag cgaaaccggc agacgaacga acggatcgag gagatcatcc ggaccaccgg     1980

gaaggaaaac gcgaagtacc tgatcgagaa aatcaagctg catgatatgc aggaagggaa     2040

gtgtctctac tccctggagg ccattccgct ggaggatttg ctgaacaacc ctttcaacta     2100

cgaagtcgat catatcattc ctcgctccgt gtccttcgat aactccttca acaataaggt     2160

cctcgtgaag caggaggaga agtaagtatc aaggttacaa gacaggttta aggagaccaa     2220

tagaaactgg gctcgagaat gcgacgggtg tggtacgcag ccacttcgag tacccacagt     2280

actacctgct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     2340

actgacatcc actttgcctt tctctccaca gctcgaagaa gggcaacaga accccgttcc     2400

agtacctctc gtcgtccgac tccaagatca gctacgaaac tttcaagaag cacattctga     2460

acctggccaa gggcaaaggg agaattagca agaccaagaa ggaatacctc ctggaagaga     2520

gagacatcaa ccgcttctcg gtgcaaaagg atttcatcaa ccgcaacctg gtcgatacca     2580

gatacgccac caggggactg atgaacctcc tgcggtccta cttccgggtc aacaatctgg     2640

acgtgaaggt caaatccatc aacgggggct ttacttcttt cctgcgccgg aagtggaagt     2700

tcaagaagga acggaacaag ggatacaagc accacgctga agatgccctg attattgcca     2760

acgccgactt catctttaag gaatggaaaa agctggacaa ggctaagaag gtcatggaga     2820

accagatgtt cgaagaaaag caggccgagt ccatgcccga aatcgaaacc gagcaggaat     2880

acaaggagat cttcatcaca ccgcaccaaa tcaagcacat caaggacttc aaggattaca     2940

agtacagcca ccgggtggac aagaagccta acagagagct tatcaacgac accctgtact     3000

ccacgcgcaa ggacgacaag ggaaacacat tgatcgtgaa caacctgaac ggactgtatg     3060

acaaggacaa tgacaaactg aagaagctga tcaacaaatc gccggaaaag ctcctgatgt     3120

accatcacga ccctcaaacc taccagaaac tgaagctcat catggagcag tacggcgacg     3180

aaaagaatcc cctgtacaaa tactacgagg agactggaaa ttacctgact aagtactcca     3240

agaaggataa cggccccgtg atcaagaaga ttaagtacta cggaaacaaa ctgaacgcac     3300

atctcgacat caccgatgat tatccaaact cccgcaacaa agtcgtgaag ctctccctca     3360

aaccgtaccg cttcgacgtg tacctggata atggggtgta caagttcgtg accgtgaaga     3420

acctggacgt cattaagaag gaaaactact acgaagtgaa ctcaaagtgc tacgaggaag     3480

ccaagaagct caagaagatc agcaaccagg ccgagttcat cgcatcgttt tacaacaatg     3540

acctcattaa gattaatgga gaactgtaca gagtgatcgg cgtgaacaac gacctcctga     3600

accggattga agtgaacatg atcgatatta cctaccggga gtatctggag aacatgaacg     3660

acaagcgccc accgagaatc atcaaaacta ttgcctccaa gacccaatcc attaagaaat     3720

actccaccga catcctgggc aacctgtacg aggtcaagtc gaagaagcac ccccagatta     3780

tcaagaaggg aaaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg     3840

cttaagaatt cctagagctc gctgatcagc ctcgaaactt gtttattgca gcttataatg     3900

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     3960

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccagcaggct     4020

ttcctaggtt cgaacgctga cgtcatcaac ccgctccaag gaatcgcggg cccagtgtca     4080

ctaggcggga acacccagcg cgcgtgcgcc ctggcaggaa gatggctgtg agggacaggg     4140

gagtggcgcc ctgcaatatt tgcatgtcgc tatgtgttct gggaaatcac cataaacgtg     4200

aaatccctat cagtgataga gacttataag ttccctatca gtgatagaga caccgggtgt     4260

ggtacgcagc cactgtttaa gtactctgtg ctggaaacag cacagaatct acttaaacaa     4320

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga ttttttcacg tgcggaccga     4380

ggctgcagcg tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc     4440

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4500

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt     4560

ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc     4620

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     4680

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     4740

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     4800

tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc     4860

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     4920

cttgttccaa actggaacaa cactcaaccc tatctcgggc tattcttttg atttataagg     4980

gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc     5040

gaattttaac aaaatattaa cgtttacaat tttatggtgc actctcagta caatctgctc     5100

tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg     5160

ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat     5220

gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg     5280

cctattttta taggttaatg tcatgaacaa taaaactgtc tgcttacata aacagtaata     5340

caaggggtgt tatgagccat attcaacggg aaacgtcgag gccgcgatta aattccaaca     5400

tggatgctga tttatatggg tataaatggg ctcgcgataa tgtcgggcaa tcaggtgcga     5460

caatctatcg cttgtatggg aagcccgatg cgccagagtt gtttctgaaa catggcaaag     5520

gtagcgttgc caatgatgtt acagatgaga tggtcagact aaactggctg acggaattta     5580

tgcctcttcc gaccatcaag cattttatcc gtactcctga tgatgcatgg ttactcacca     5640

ctgcgatccc cggaaaaaca gcattccagg tattagaaga atatcctgat tcaggtgaaa     5700

atattgttga tgcgctggca gtgttcctgc gccggttgca ttcgattcct gtttgtaatt     5760

gtccttttaa cagcgatcgc gtatttcgtc tcgctcaggc gcaatcacga atgaataacg     5820

gtttggttga tgcgagtgat tttgatgacg agcgtaatgg ctggcctgtt gaacaagtct     5880

ggaaagaaat gcataaactt ttgccattct caccggattc agtcgtcact catggtgatt     5940

tctcacttga taaccttatt tttgacgagg ggaaattaat aggttgtatt gatgttggac     6000

gagtcggaat cgcagaccga taccaggatc ttgccatcct atggaactgc ctcggtgagt     6060

tttctccttc attacagaaa cggctttttc aaaaatatgg tattgataat cctgatatga     6120

ataaattgca gtttcatttg atgctcgatg agtttttcta atctcatgac caaaatccct     6180

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     6240

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     6300

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     6360

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     6420

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     6480

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     6540

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     6600

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg     6660

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     6720

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     6780

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     6840

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgt                 6889


<210>  40
<211>  6901
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  40
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgggt gtggtacgca gccactgttt aagtactctg tgctggaaac agcacagaat     4320

ctacttaaac aaggcaaaat gccgtgttta tctcgtcaac ttgttggcga gattttttca     4380

cgtgcggacc gaggctgcag cgtcgtcctc cctaggaacc cctagtgatg gagttggcca     4440

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4500

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc     4560

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata cgtcaaagca     4620

accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     4680

cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt     4740

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     4800

ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg atggttcacg     4860

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     4920

taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg gctattcttt     4980

tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca     5040

aaaatttaac gcgaatttta acaaaatatt aacgtttaca attttatggt gcactctcag     5100

tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga     5160

cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc     5220

cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg     5280

cctcgtgata cgcctatttt tataggttaa tgtcatgaac aataaaactg tctgcttaca     5340

taaacagtaa tacaaggggt gttatgagcc atattcaacg ggaaacgtcg aggccgcgat     5400

taaattccaa catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc     5460

aatcaggtgc gacaatctat cgcttgtatg ggaagcccga tgcgccagag ttgtttctga     5520

aacatggcaa aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc     5580

tgacggaatt tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat     5640

ggttactcac cactgcgatc cccggaaaaa cagcattcca ggtattagaa gaatatcctg     5700

attcaggtga aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc     5760

ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac     5820

gaatgaataa cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg     5880

ttgaacaagt ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca     5940

ctcatggtga tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta     6000

ttgatgttgg acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact     6060

gcctcggtga gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata     6120

atcctgatat gaataaattg cagtttcatt tgatgctcga tgagtttttc taatctcatg     6180

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     6240

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     6300

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     6360

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     6420

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     6480

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     6540

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     6600

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     6660

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     6720

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     6780

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     6840

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     6900

t                                                                     6901


<210>  41
<211>  8469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  41
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgggt gtggtacgca gccactgttt aagtactctg tgctggaaac agcacagaat     4320

ctacttaaac aaggcaaaat gccgtgttta tctcgtcaac ttgttggcga gattttttca     4380

cgtgcggacc gaggctgcag cgtcgtcctc cctaggaacc cctagtgatg gagttggcca     4440

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4500

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc     4560

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata cgtcaaagca     4620

accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     4680

cgtgaccgct acacttgcca gcgccttagc gcccgctcct ttcgctttct tcccttcctt     4740

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     4800

ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg atggttcacg     4860

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     4920

taatagtgga ctcttgttcc aaactggaac aacactcaac tctatctcgg gctattcttt     4980

tgatttataa gggattttgc cgatttcggt ctattggtta aaaaatgagc tgatttaaca     5040

aaaatttaac gcgaatttta acaaaatatt aacgttagcg ctgacattga ttattgacta     5100

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg     5160

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     5220

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     5280

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     5340

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     5400

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     5460

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     5520

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     5580

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     5640

ggtgggaggt ctatataagc agagctctct ggctaactag agaacccact gcttactggc     5700

ttatcgttaa ttaaccggtg ccaccatgat gtcccgcctt gataaatcaa aagtaataaa     5760

cagtgctctt gagcttctca atgaagttgg tatagaaggg ttgacgactc ggaaattggc     5820

gcaaaaactc ggtgttgagc agccaacctt gtattggcat gttaaaaaca aacgagcact     5880

cctcgacgct ttggcgatag agatgctgga caggcaccac acgcatttct gtcccctcga     5940

aggagagtca tggcaggatt tccttagaaa taacgcaaag tccttcagat gtgcgctgct     6000

tagtcaccgc gacggcgcaa aagttcatct cggcactagg ccaaccgaga aacagtacga     6060

gactctggag aaccaactgg cgtttttgtg tcaacagggt tttagtctcg aaaatgcgct     6120

ctatgctctc tctgcggttg gccatttcac cctcggatgc gtactggaag atcaggagca     6180

ccaagtggcc aaagaagaac gggaaacgcc gactacggac agcatgcctc cgttgctccg     6240

gcaagctata gagctcttcg atcaccaagg cgctgagcca gctttcttgt tcggattgga     6300

acttattata tgcgggctcg aaaagcagct taaatgcgag tcaggttaag tttaaacccg     6360

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     6420

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     6480

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     6540

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc     6600

ttctgagtta gtccattgtc gacttccgag gaccgcggaa cgtttacaat tttatggtgc     6660

actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca     6720

cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg     6780

accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga     6840

cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgaacaa taaaactgtc     6900

tgcttacata aacagtaata caaggggtgt tatgagccat attcaacggg aaacgtcgag     6960

gccgcgatta aattccaaca tggatgctga tttatatggg tataaatggg ctcgcgataa     7020

tgtcgggcaa tcaggtgcga caatctatcg cttgtatggg aagcccgatg cgccagagtt     7080

gtttctgaaa catggcaaag gtagcgttgc caatgatgtt acagatgaga tggtcagact     7140

aaactggctg acggaattta tgcctcttcc gaccatcaag cattttatcc gtactcctga     7200

tgatgcatgg ttactcacca ctgcgatccc cggaaaaaca gcattccagg tattagaaga     7260

atatcctgat tcaggtgaaa atattgttga tgcgctggca gtgttcctgc gccggttgca     7320

ttcgattcct gtttgtaatt gtccttttaa cagcgatcgc gtatttcgtc tcgctcaggc     7380

gcaatcacga atgaataacg gtttggttga tgcgagtgat tttgatgacg agcgtaatgg     7440

ctggcctgtt gaacaagtct ggaaagaaat gcataaactt ttgccattct caccggattc     7500

agtcgtcact catggtgatt tctcacttga taaccttatt tttgacgagg ggaaattaat     7560

aggttgtatt gatgttggac gagtcggaat cgcagaccga taccaggatc ttgccatcct     7620

atggaactgc ctcggtgagt tttctccttc attacagaaa cggctttttc aaaaatatgg     7680

tattgataat cctgatatga ataaattgca gtttcatttg atgctcgatg agtttttcta     7740

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     7800

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     7860

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     7920

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     7980

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     8040

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     8100

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     8160

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     8220

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     8280

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     8340

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     8400

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     8460

ctcacatgt                                                             8469


<210>  42
<211>  7242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  42
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgggt gtggtacgca gccactgttt aagtactctg tgctggaaac agcacagaat     4320

ctacttaaac aaggcaaaat gccgtgttta tctcgtcaac ttgttggcga gattttttca     4380

cgtgcggacc gaggctgcag cgtcgtcctc cctaggaacc cctagtgatg gagttggcca     4440

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4500

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc     4560

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata cgtcaaagca     4620

accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     4680

cgtgaccgct acacttgcca gcgccttagc gcccgctcct ttcgctttct tcccttcctt     4740

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     4800

ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg atggttcacg     4860

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     4920

taatagtgga ctcttgttcc aaactggaac aacactcaac tctatctcgg gctattcttt     4980

tgatttataa gggattttgc cgatttcggt ctattggtta aaaaatgagc tgatttaaca     5040

aaaatttaac gcgaatttta acaaaatatt aacgttagcg cttccattgt cgacttccga     5100

ggacgagggc ctatttccca tgattccttc atatttgcat atacgataca aggctgttag     5160

agagataatt ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg     5220

tagaaagtaa taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta     5280

tcatatgctt accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa     5340

aggacgaaac accggagctt catccagtcg atcacgaatg atcgactgga tgaagctcct     5400

tttttccgcg gaacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     5460

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     5520

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     5580

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     5640

ttataggtta atgtcatgaa caataaaact gtctgcttac ataaacagta atacaagggg     5700

tgttatgagc catattcaac gggaaacgtc gaggccgcga ttaaattcca acatggatgc     5760

tgatttatat gggtataaat gggctcgcga taatgtcggg caatcaggtg cgacaatcta     5820

tcgcttgtat gggaagcccg atgcgccaga gttgtttctg aaacatggca aaggtagcgt     5880

tgccaatgat gttacagatg agatggtcag actaaactgg ctgacggaat ttatgcctct     5940

tccgaccatc aagcatttta tccgtactcc tgatgatgca tggttactca ccactgcgat     6000

ccccggaaaa acagcattcc aggtattaga agaatatcct gattcaggtg aaaatattgt     6060

tgatgcgctg gcagtgttcc tgcgccggtt gcattcgatt cctgtttgta attgtccttt     6120

taacagcgat cgcgtatttc gtctcgctca ggcgcaatca cgaatgaata acggtttggt     6180

tgatgcgagt gattttgatg acgagcgtaa tggctggcct gttgaacaag tctggaaaga     6240

aatgcataaa cttttgccat tctcaccgga ttcagtcgtc actcatggtg atttctcact     6300

tgataacctt atttttgacg aggggaaatt aataggttgt attgatgttg gacgagtcgg     6360

aatcgcagac cgataccagg atcttgccat cctatggaac tgcctcggtg agttttctcc     6420

ttcattacag aaacggcttt ttcaaaaata tggtattgat aatcctgata tgaataaatt     6480

gcagtttcat ttgatgctcg atgagttttt ctaatctcat gaccaaaatc ccttaacgtg     6540

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc     6600

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg     6660

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag     6720

cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact     6780

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg     6840

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc     6900

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg     6960

aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg     7020

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag     7080

ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc     7140

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct     7200

ttttacggtt cctggccttt tgctggcctt ttgctcacat gt                        7242


<210>  43
<211>  8771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  43
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgggt gtggtacgca gccactgttt aagtactctg tgctggaaac agcacagaat     4320

ctacttaaac aaggcaaaat gccgtgttta tctcgtcaac ttgttggcga gattttttca     4380

cgtgcggacc gaggctgcag cgtcgtcctc cctaggaacc cctagtgatg gagttggcca     4440

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4500

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc     4560

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata cgtcaaagca     4620

accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     4680

cgtgaccgct acacttgcca gcgccttagc gcccgctcct ttcgctttct tcccttcctt     4740

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     4800

ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg atggttcacg     4860

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     4920

taatagtgga ctcttgttcc aaactggaac aacactcaac tctatctcgg gctattcttt     4980

tgatttataa gggattttgc cgatttcggt ctattggtta aaaaatgagc tgatttaaca     5040

aaaatttaac gcgaatttta acaaaatatt aacgttagcg ctgacattga ttattgacta     5100

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg     5160

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     5220

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     5280

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     5340

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     5400

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     5460

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat     5520

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     5580

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac     5640

ggtgggaggt ctatataagc agagctctct ggctaactag agaacccact gcttactggc     5700

ttatcgttaa ttaaccggtg ccaccatgat gtcccgcctt gataaatcaa aagtaataaa     5760

cagtgctctt gagcttctca atgaagttgg tatagaaggg ttgacgactc ggaaattggc     5820

gcaaaaactc ggtgttgagc agccaacctt gtattggcat gttaaaaaca aacgagcact     5880

cctcgacgct ttggcgatag agatgctgga caggcaccac acgcatttct gtcccctcga     5940

aggagagtca tggcaggatt tccttagaaa taacgcaaag tccttcagat gtgcgctgct     6000

tagtcaccgc gacggcgcaa aagttcatct cggcactagg ccaaccgaga aacagtacga     6060

gactctggag aaccaactgg cgtttttgtg tcaacagggt tttagtctcg aaaatgcgct     6120

ctatgctctc tctgcggttg gccatttcac cctcggatgc gtactggaag atcaggagca     6180

ccaagtggcc aaagaagaac gggaaacgcc gactacggac agcatgcctc cgttgctccg     6240

gcaagctata gagctcttcg atcaccaagg cgctgagcca gctttcttgt tcggattgga     6300

acttattata tgcgggctcg aaaagcagct taaatgcgag tcaggttaag tttaaacccg     6360

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     6420

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     6480

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     6540

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc     6600

ttctgagtta gtccattgtc gacttccgag gacgagggcc tatttcccat gattccttca     6660

tatttgcata tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac     6720

acaaagatat tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca     6780

gttttaaaat tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc     6840

gatttcttgg ctttatatat cttgtggaaa ggacgaaaca ccggagcttc atccagtcga     6900

tcacgaatga tcgactggat gaagctcctt ttttccgcgg aacgtttaca attttatggt     6960

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     7020

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     7080

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     7140

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgaac aataaaactg     7200

tctgcttaca taaacagtaa tacaaggggt gttatgagcc atattcaacg ggaaacgtcg     7260

aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg ggctcgcgat     7320

aatgtcgggc aatcaggtgc gacaatctat cgcttgtatg ggaagcccga tgcgccagag     7380

ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga gatggtcaga     7440

ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat ccgtactcct     7500

gatgatgcat ggttactcac cactgcgatc cccggaaaaa cagcattcca ggtattagaa     7560

gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct gcgccggttg     7620

cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag     7680

gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga cgagcgtaat     7740

ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt ctcaccggat     7800

tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga ggggaaatta     7860

ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga tcttgccatc     7920

ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt tcaaaaatat     7980

ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga tgagtttttc     8040

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     8100

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     8160

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     8220

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     8280

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     8340

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     8400

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     8460

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     8520

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     8580

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     8640

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     8700

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     8760

tgctcacatg t                                                          8771


<210>  44
<211>  5823
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding BFP reporter construct

<400>  44
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca ggctagccac catgggcctg aggctacagc      540

tctccctggg catcatccca gttgaggagg agaacccgga cttctggaac cgcgaggcag      600

ccgaggccct gggtgccgcc aagaagctgc agcctgcaca gacagccgcc aagaacctca      660

tcatcttcct gggcgatggg atgggggtgt ctacggtgac agctgccagg atcgatctgc      720

ttcctggccc tgctgggcct gctcatcctc tgggagccct ggcctgccca ggcttttgtc      780

aacagcacct ttgtggttct cacttggtgg aagctctcta cctggtgtgt ggggagcgtg      840

gattcttcta cacacccatg tcccgccgcg aagtggagga cccacaaggt aagctctgct      900

cctgaattaa ttctatccca agtgctaact accctgtttg tctttcaccc ttgagacctt      960

gtaaattgtg ccctaggtgt ggagggtctc aggctaacca gtggggggca catttctgtg     1020

ggcagctaga catatgtaaa catggtagct gccaggaagg agtgagaatc cttccttaag     1080

tctcctaggt ggtgacgggt ggctaggccc caggataggt accgggcccc ccctcgagca     1140

ttaaataatg ttacttatgt tatacagccc atttcctttt ttatcagagt caggctgaaa     1200

gttcattttt ctgcaaaact gcagtgccca ttcttaattt ttgttttgag aaataactgt     1260

tgtaccctct ttattatcac aagattaata atatttcttt attttattgc tcctcttaca     1320

tttggatctt ttattatgag ctgtcaaaaa ttcttttggg aagtagttgg ggtataaata     1380

ataaatcgat aaaagaattc atgattaaag acaagataga atccattatt ctgttaacat     1440

atcagtagtg aataacaaaa ggctacattg acaattagca tgcaatatat tgctttatat     1500

aattatacat ccatatattt gccactttga tttttaattc actggtaaat ttaggggata     1560

ctcatttatg gagttaatat taccaaaaag agtttttaaa ctgagcgagg ctttaattag     1620

aatggtaaaa tattgcttca gggcaacaat gagaatgtaa caagaaaact gactgatcag     1680

tcatgggtaa ctcgaatagc aaacaagtag agaagactca caaaaccact gaaagttata     1740

tacacactca agttgtgagt cattcaaact gggtattcat acacatgtat acaaatacaa     1800

acaagtgtgt gcgcacacac cctttccaat atacacacct gaatataaaa ctaaataagc     1860

agattcctct gttaacaatt ttattactct attttaggct ggggctgaac ttttgaagct     1920

gatgagcaaa atagtttccc ataaaagata atttcatttg ccaaaatgaa actactttcc     1980

gttattaatg ttgcaatgaa atggtttgaa atatgagtct gtgatctgga cagaaaggat     2040

gctcctgttc ccagctccaa gagggagttc tctaaacaat tacacccacg gagagcgctg     2100

taaggttgta ttttcatcac cggccagctg agctgtgtgc ctgtcatact cccagtctcc     2160

cctccagtga cagccgcatt gacaacatgt tatactccac attgatttta cagttaagga     2220

gctgattgtg atatatagag attttaagaa ttcagctgag aggctgactt ttgcctttta     2280

tcattccatt aaaattttat aaccatcttt ttcatgtcat ttcatccatg aattcttact     2340

ttagaaagtg atagctactg ctgtgagcat aacttttctc atgttcagag ctttttattg     2400

tattagcaaa ctaccccaat tatagttatt actcatgttt tacataattg tggtggccct     2460

ttcaaccatg cagttgcagg ccagttgatt tgtatataga attagatgat tcggcttatc     2520

attttaaagc actaaattga aagagtgcca ggagtcaggt tttaacactt ccctagccaa     2580

aggagctaat taagctgctt tcagcttcct ctccagaatc acacaagtta aaggaccctt     2640

ctgcaacaag agcagcgaat ctactcagcc agagcaggaa gctaataaaa tgtatgctgg     2700

cttttaaggg ggaaacaaat catgaaattg aaattgaaca cctctccttt cccaaggtaa     2760

gagatcatct ttaagaaaag gctgtgtatt gtgggggttt gaagtgcaag ttcatctcat     2820

tatcatggat gtttcaccca taatactatc atcatatgca ggagaaataa aagccttatc     2880

ccccaatcac agagaacaaa ctgcatcatt gttgtttctt ttccctgaag atgctcacag     2940

tttgatagtt cacatatgag gaataattat gcaagaccca gatgaaaacc ctaataaaaa     3000

atattctgat ttttaagtgt atattactct ctttggggaa gagagggtga gataaggtta     3060

gacattaaag acttgaatct ccaccattga ttttacgaaa cccaatctca ggggatttgg     3120

gggttttttt agatttcaaa acaacattga tatcttacaa gactcgtact tgcttttctc     3180

tgggaaatag ccaaatctag atgacaagca taaataagaa aggagctgta tccccatttt     3240

gatataataa ttgctactgc tactgtatac cagagagcaa aagtaagaaa tggcatagtg     3300

gttttaagaa agctttaaaa tgaaagctaa caagagactg aaacggaaag tgtgatttat     3360

accatgactg ctggttttag ggtttttttt agggatttct cttcaaatag gatacattac     3420

caaattgtca gaaatagctt gatttcagag ttagtgcact ataacatctt ttgcttcgaa     3480

aagtgattat gattctacca tcagtccagt tggtgacaaa tacgtggatc ctgttgtgtg     3540

aaagtgtact catataacca actattattg cagtcactgg ccctgcaaag cagtggttgc     3600

atttaaaatt tcaaccttct ttgtaacact gaatcgcata cacacactca caagatcaac     3660

gctgttttaa acaattacta aatccaagta tatctttttt aaagattttc aataaaatct     3720

aatgttcaca gaaaaatctc ataaatgtca aaattgctgt gggcagaaaa ggggggatac     3780

agtattttct tgatctgttt tagcaattta tagatttcag gccgtggttt ataagaatgc     3840

taaatgttct ggaattacag ctgttactga tcagtgattg agccagattt gtgttattgc     3900

accatgttct tgcttgtacc tagagagcag taaagcctca atataataaa aagcacctgc     3960

attttaaatg aaatttcaat tgaaaaactt aacagccctt caaattgcag aatttaacgc     4020

agcccagtaa agcttaaata acactttgcc cccgcaggct gaggggtttg cattcaaggt     4080

gacttgattg tgtcgcatgg tgaaattatt tacaattaag gaatttctct ggagggctgc     4140

agaatatttg ctgttccaca acacctatgc aggcatatgg tgggcctttt tcagtattca     4200

tggagcctcc tgaaccttta tgataattga atcagttaga gtgctgagtg gagcaagcat     4260

aaaacctgtt aacctaaagg tcagatctga gctcggtacc tatttgggga ccccatagag     4320

cactgcactg actgagggat ggtaacagga tgtgtaggtt ttggaggccc atatgtccat     4380

tcatgaccag tgacttgtct cacagccatg caacccttgc ctcctgtgct gacttagcag     4440

gggataaagt gagagaaagc ctgggctaat cagggggtcg ctcagctcct cctaactgga     4500

ttgtcctatg tgtctttgct tctgtgctgc tgatgctctg ccctgtgctg acatgacctc     4560

cctggcagtg gcacaactgg agctgggtgg aggcccggga agcggggcta ccaacttcag     4620

tctcctcaaa caagctggcg atgtggagga aaatccaggt ccggtgtcta agggcgaaga     4680

gctgattaag gagaacatgc acatgaagct gtacatggag ggcaccgtgg acaaccatca     4740

cttcaagtgc acatccgagg gcgaaggcaa gccctacgag ggcacccaga ccatgagaat     4800

caaggtggtc gagggcggcc ctctcccctt cgccttcgac atcctggcta ctagcttcct     4860

ctacggcagc aagaccttca tcaaccacac ccagggcatc cccgacttct tcaagcagtc     4920

cttccctgag ggcttcacat gggagagagt caccacatac gaagacgggg gcgtgctgac     4980

cgctacccag gacaccagcc tccaggacgg ctgcctcatc tacaacgtca agatcagagg     5040

ggtgaacttc acatccaacg gccctgtgat gcagaagaaa acactcggct gggaggcctt     5100

caccgagacg ctgtaccccg ctgacggcgg cctggaaggc agaaacgaca tggccctgaa     5160

gctcgtgggc gggagccatc tgatcgcaaa cgccaagacc acatatagat ccaagaaacc     5220

cgctaagaac ctcaagatgc ctggcgtcta ctatgtggac tacagactgg aaagaatcaa     5280

ggaggccaac aacgagacct acgtcgagca gcacgaggtg gcagtggcca gatactgcga     5340

cctccctagc aaactggggc acaaacttaa ttgaccttca gaccttggca ctggaggtgg     5400

cccggcagaa gcgcggcatc gtggatcagt gctgcaccag catctgctct ctctaccaac     5460

tggagaacta ctgcaactag gcccaccact accctgtcca cccctctgca atgaataaaa     5520

cctttgaaag agcactacaa gttgtgtgta catgcgtgca tgtgcatatg tggtgcgggg     5580

ggaacatgag tggggctggc tggagtggcg atgataagct gtcaaacatg agaattcttg     5640

aagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt     5700

ttcttagacg tttaaacggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg     5760

aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg     5820

ttc                                                                   5823


<210>  45
<211>  8229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  45
ctgggcggtt ctgataacga gtaatcgtta atccgcaaat aacgtaaaaa cccgcttcgg       60

cgggtttttt tatgggggga gtttagggaa agagcatttg tcagaatatt taagggcgcc      120

tgtcactttg cttgatatat gagaattatt taaccttata aatgagaaaa aagcaacgca      180

ctttaaataa gatacgttgc tttttcgatt gatgaacacc tataattaaa ctattcatct      240

attatttatg attttttgta tatacaatat ttctagtttg ttaaagagaa ttaagaaaat      300

aaatctcgaa aataataaag ggaaaatcag tttttgatat caaaattata catgtcaacg      360

ataatacaaa atataataca aactataaga tgttatcagt atttattatg catttagaat      420

aaattttgtg tcgcccttat tcgactcact atagaagttc ctattctcta gaaagtatag      480

gaacttcact tcattttgct agcggtgtga gggcctattt cccatgattc cttcatattt      540

gcatatacga tacaaggctg ttagagagat aattggaatt aatttgactg taaacacaaa      600

gatattagta caaaatacgt gacgtagaaa gtaataattt cttgggtagt ttgcagtttt      660

aaaattatgt tttaaaatgg actatcatat gcttaccgta acttgaaagt atttcgattt      720

cttggcttta tatatcttgt ggaaaggacg aaacaccgtt aaagatgatc tcttacctgt      780

ttcagtactc tggaaacaga atctactgaa acaagacaat atgtcgtgtt tatcccatca      840

atttattggt gggatttttt tcaacaccgg taccgcgtta cataacttac ggtaaatggc      900

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caatagtaac gccaataggg      960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     1020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     1080

tggcattgtg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     1140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     1200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     1260

atgggggcgg gggggggggg ggcgcgcgcc aggtggggcg gggcggggcg aggggcgggg     1320

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc     1380

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg     1440

agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc     1500

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc     1560

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt     1620

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gcaaccgcgg     1680

acacccaagc ggccgccacc atggattaca aagaccacga cggagactac aaggatcacg     1740

acattgatta caaggatgat gatgataagg ccccaaagaa gaagcggaag gtcggtatcc     1800

acggagtccc agcagccgga tccgccatga accagaagtt cattctcggt ctggacattg     1860

gcattactag cgtgggatac ggcttgattg actacgagac taagaacatc atcgatgccg     1920

gcgtccgcct gttcccggaa gccaacgtgg agaacaatga gggccggagg tcgaagagag     1980

gctcccgccg cctgaagcgg cggcgaatcc accggctgga gagagtgaag ctgctgctca     2040

ccgaatacga cctgatcaac aaagaacaga tcccgacctc caacaacccg taccagatca     2100

gagtgaaggg tctgtcagaa atcctgtcca aggacgaact ggcaatcgcc ctgctgcacc     2160

tggccaagcg gcgcggaatc cacaacgtgg atgtggctgc cgacaaggaa gaaaccgctt     2220

ccgactccct gagcactaag gaccagatca acaagaacgc caagttcttg gagtcccgct     2280

acgtgtgcga gctgcagaag gaacggctgg aaaacgaagg tcacgtgcgc ggagtggaaa     2340

accggttcct gacaaaggac attgtgcgcg aagcgaagaa gatcattgat acccaaatgc     2400

agtactaccc tgaaatcgac gagactttca aggaaaagta catttccctg gtggaaaccc     2460

ggcgggaata cttcgaaggc cccggacagg gatcgccgtt cggatggaac ggggacctca     2520

agaagtggta cgagatgctg atggggcact gtacctactt tccgcaagaa ctgcgctccg     2580

tgaagtacgc gtactccgcg gatctcttca acgcgttgaa tgacctgaac aacctgatca     2640

ttcagagaga caattccgaa aagctcgagt accacgagaa gtatcacatc atcgagaatg     2700

tgttcaagca gaagaagaaa ccgaccctca agcaaatcgc caaggagatt ggcgtcaacc     2760

cagaggacat caagggatat cggattacca agagcggcac tcccgagttt acctctttca     2820

agctgtttca tgatctgaag aaagtcgtga aggaccatgc cattctcgac gacattgatc     2880

tcctgaatca gatcgcagag atcctgacta tctaccaaga caaggactcg attgtggcag     2940

agctgggtca gctcgaatac ctgatgtccg aggccgacaa gcagtccatc tccgaactga     3000

cagggtacac ggggactcat agcctgtcgc tgaagtgcat gaacatgatc attgatgaac     3060

tgtggcacag ctccatgaac caaatggaag tgtttaccta cctcaacatg cgccctaaga     3120

agtacgaact gaaaggctac cagcgcatcc ccaccgacat gatcgacgac gcgatcttgt     3180

cccctgtggt caagaggacc ttcattcaat ccatcaacgt gatcaacaag gtcatcgaaa     3240

agtacggaat accagaagat atcatcattg agctcgctcg ggagaacaac tcggatgacc     3300

ggaagaagtt catcaacaat cttcagaaga agaacgaagc gactcggaaa cggatcaacg     3360

agatcatcgg acagaccgga aaccagaacg ccaaacggat tgtcgaaaag attagactgc     3420

acgaccagca ggaagggaag tgcctgtact cactcgagtc aataccgctc gaggacctgt     3480

tgaacaaccc taaccactat gaagtggacc acatcatccc tcggtccgtg agcttcgaca     3540

actcgtacca caacaaagtg ctcgtgaagc agtccgaaaa ctccaagaaa tccaacctga     3600

ccccgtacca atacttcaat tcgggaaagt cgaagctgtc gtacaaccag ttcaaacaac     3660

acatactcaa ccttagcaaa agccaggatc gcatttccaa gaagaagaag gaatacctcc     3720

tcgaggaaag ggacatcaac aagttcgaag tgcagaaaga gttcatcaat cgcaacttgg     3780

tggataccag atatgccacc cgggaactca ccaactatct caaggcctac ttttccgcca     3840

acaacatgaa cgtgaaggtc aagaccatca acgggtcctt cactgactac ctgagaaagg     3900

tctggaagtt caagaaggaa cgcaaccacg gatacaagca ccacgctgag gacgctctga     3960

tcatcgccaa tgccgacttc ctgttcaagg aaaacaagaa gctgaaagct gtcaactcag     4020

tgctggaaaa gcctgaaatc gagactaagc agctggatat ccaagtggac tctgaggaca     4080

actacagcga gatgttcatc atccctaaac aagtgcagga tatcaaggac tttcgcaact     4140

tcaagtactc acaccgggtg gacaagaaac cgaatagaca gctgatcaac gacacgttgt     4200

attccacccg gaagaaggat aactcaacct acattgtgca gactatcaag gatatctacg     4260

ccaaagataa cactactctg aagaaacaat tcgacaagtc cccagagaag ttcctgatgt     4320

accagcacga cccccgaacc tttgagaagc ttgaagtgat catgaagcag tacgccaacg     4380

agaagaaccc gctggccaag taccatgaag aaaccggaga atacctgacc aagtacagca     4440

agaagaacaa cggtcccatt gtcaagagcc tgaagtacat cggcaacaag ctgggatccc     4500

acctcgacgt gacacatcag ttcaagtcgt cgactaagaa gcttgtgaag ctgtcaatca     4560

agaactatag attcgacgtg tacttgaccg aaaagggata caagttcgtg accatagcct     4620

atctgaacgt gttcaagaaa gataactact actacatccc caaggacaag taccaggagc     4680

tcaaagaaaa gaagaagatc aaagacaccg accagttcat tgcctccttc tacaagaacg     4740

acctgatcaa actgaacggc gacctctaca agatcattgg agtgaacagc gatgacagga     4800

acatcattga gctggactac tacgacatca agtacaagga ctactgcgag atcaacaaca     4860

tcaagggcga accccggatc aagaaaacta ttggaaagaa aaccgagtcc attgagaagt     4920

tcaccactga cgtgctggga aacctttacc tccactccac cgagaaggca ccacaactga     4980

tcttcaagcg cggcctgggt ggaaagctta aaaggccggc ggccacgaaa aaggccggcc     5040

aggcaaaaaa gaaaaagggt actagtgagg gcaggggaag tctgctaaca tgcggggacg     5100

tggaggaaaa tcccggcccc atgactgccc tgaccgaagg tgctaagctg tttgagaagg     5160

agattccgta catcaccgag ctggaagggg acgtcgaagg aatgaagttc atcatcaagg     5220

gagaaggaac cggggacgct acgactggaa ccattaaggc caagtatatc tgtaccactg     5280

gagatctgcc agtgccttgg gccacccttg tgtcaaccct ctcgtatgga gtgcagtgtt     5340

ttgctaagta ccctagccac attaaggact tcttcaaatc cgccatgccg gaaggttata     5400

cccaagagcg caccatttct tttgagggag atggagtgta caagacccgc gcgatggtca     5460

cctatgagag gggatctatc tacaaccggg tgactctgac tggagaaaac tttaagaagg     5520

acgggcatat tcttcggaag aatgtcgcct tccagtgccc tcccagcatc ctttacattc     5580

tccccgacac tgtgaacaac ggaatccgcg tggagttcaa tcaagcctac gacatcgagg     5640

gggtgacgga gaagctggtg accaagtgta gccagatgaa tcggccactg gccggttcag     5700

cggctgtcca cattccgcgc taccatcata tcacttatca cactaagctc tccaaagacc     5760

gcgatgagag gagagatcac atgtgcctgg tggaagtggt caaggccgtc gatctcgata     5820

cctatcagta agtcgactga ataagtgaac tcgagatcag cctcgactgt gccttctagt     5880

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     5940

cccactgtcc tttcctaata aaatgaggaa attgcatccc cacttcagaa gttcctatac     6000

tttctagaga ataggaactt cactatagag tcgaataagg gcgacacccc ctaattagcc     6060

cgggcgaaag gcccagtctt tcgactgagc ctttcgtttt atttgatgcc tggcagttcc     6120

ctactctcgc atggggagtc cccacactac catcggcgct acggcgtttc acttctgagt     6180

tcggcatggg gtcaggtggg accaccgcgc tactgccgcc aggcaaacaa ggggtgttat     6240

gagccatatt caggtataaa tgggctcgcg ataatgttca gaattggtta attggttgta     6300

acactgaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     6360

caataaccct gataaatgct tcaataatat tgaaaaagga agaatatgag ccatattcaa     6420

cgggaaacgt cgaggccgcg attaaattcc aacatggatg ctgatttata tgggtataaa     6480

tgggctcgcg ataatgtcgg gcaatcaggt gcgacaatct atcgcttgta tgggaagccc     6540

gatgcgccag agttgtttct gaaacatggc aaaggtagcg ttgccaatga tgttacagat     6600

gagatggtca gactaaactg gctgacggaa tttatgccac ttccgaccat caagcatttt     6660

atccgtactc ctgatgatgc atggttactc accactgcga tccccggaaa aacagcgttc     6720

caggtattag aagaatatcc tgattcaggt gaaaatattg ttgatgcgct ggcagtgttc     6780

ctgcgccggt tgcactcgat tcctgtttgt aattgtcctt ttaacagcga tcgcgtattt     6840

cgcctcgctc aggcgcaatc acgaatgaat aacggtttgg ttgatgcgag tgattttgat     6900

gacgagcgta atggctggcc tgttgaacaa gtctggaaag aaatgcataa acttttgcca     6960

ttctcaccgg attcagtcgt cactcatggt gatttctcac ttgataacct tatttttgac     7020

gaggggaaat taataggttg tattgatgtt ggacgagtcg gaatcgcaga ccgataccag     7080

gatcttgcca tcctatggaa ctgcctcggt gagttttctc cttcattaca gaaacggctt     7140

tttcaaaaat atggtattga taatcctgat atgaataaat tgcagtttca tttgatgctc     7200

gatgagtttt tctaaaagca gagcattacg ctgacttgac gggacggcgc aagctcatga     7260

ccaaaatccc ttaacgtgag ttacgcgcgc gtcgttccac tgagcgtcag accccgtaga     7320

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     7380

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     7440

tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc     7500

gtagttagcc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     7560

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     7620

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     7680

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     7740

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     7800

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     7860

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     7920

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     7980

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga     8040

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga     8100

agcggaaggc gagagtaggg aactgccagg catcaaacta agcagaaggc ccctgacgga     8160

tggccttttt gcgtttctac aaactctttc tgtgttgtaa aacgacggcc agtcttaagc     8220

tcgggcccc                                                             8229


<210>  46
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  46
guuaaagaug aucucuuacc uguuucagua cucuggaaac agaaucuacu gaaacaagac       60

aauaugucgu guuuauccca ucaauuuauu ggugggauuu uuuu                       104


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  47
guuaaagaug aucucuuacc u                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target DNA sequence

<400>  48
gttaaagatg atctcttacc t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of strand opposite target DNA

<400>  49
aggtaagaga tcatctttaa c                                                 21


<210>  50
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  50
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccgcga agaagatcat tgatacccga aggtatcaat      300

gatcttcttc gcttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  51
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  51
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccgcaa atcgccaagg agattggcga accaatctcc      300

ttggcgattt gcttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  52
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  52
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccgcac agctccatga accaaatcga aatttggttc      300

atggagctgt gcttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  53
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  53
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccggac cttcattcaa tccatcacga atgatggatt      300

gaatgaaggt ccttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  54
<211>  6254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  54
gacggatcgg gagatctgag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccggaa gaagttcatc aacaatccga agattgttga      300

tgaacttctt ccttttttac ccgatcccct atggtgcact ctcagtacaa tctgctctga      360

tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg      420

cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct      480

gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca      540

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      600

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      660

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      720

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      780

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      840

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      900

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      960

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     1020

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     1080

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc     1140

cactgcttac tggcttatcg ttaattaacc ggtgccacca tgatgtcccg ccttgataaa     1200

tcaaaagtaa taaacagtgc tcttgagctt ctcaatgaag ttggtataga agggttgacg     1260

actcggaaat tggcgcaaaa actcggtgtt gagcagccaa ccttgtattg gcatgttaaa     1320

aacaaacgag cactcctcga cgctttggcg atagagatgc tggacaggca ccacacgcat     1380

ttctgtcccc tcgaaggaga gtcatggcag gatttcctta gaaataacgc aaagtccttc     1440

agatgtgcgc tgcttagtca ccgcgacggc gcaaaagttc atctcggcac taggccaacc     1500

gagaaacagt acgagactct ggagaaccaa ctggcgtttt tgtgtcaaca gggttttagt     1560

ctcgaaaatg cgctctatgc tctctctgcg gttggccatt tcaccctcgg atgcgtactg     1620

gaagatcagg agcaccaagt ggccaaagaa gaacgggaaa cgccgactac ggacagcatg     1680

cctccgttgc tccggcaagc tatagagctc ttcgatcacc aaggcgctga gccagctttc     1740

ttgttcggat tggaacttat tatatgcggg ctcgaaaagc agcttaaatg cgagtcaggt     1800

taagcggccg ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc     1860

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1920

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1980

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2040

caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag     2100

ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     2160

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     2220

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     2280

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     2340

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     2400

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     2460

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     2520

tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg     2580

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     2640

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2700

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2760

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2820

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2880

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2940

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     3000

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3060

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3120

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     3180

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3240

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3300

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3360

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3420

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3480

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3540

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3600

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3660

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3720

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3780

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3840

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3900

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3960

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     4020

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     4080

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     4140

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     4200

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4260

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4320

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4380

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4440

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4500

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4560

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4620

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4680

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4740

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4800

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4860

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4920

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4980

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtt     5040

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5100

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5160

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5220

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5280

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5340

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5400

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5460

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5520

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5580

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5640

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     5700

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     5760

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     5820

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     5880

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     5940

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6000

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6060

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6120

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6180

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6240

tgccacctga cgtc                                                       6254


<210>  55
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  55
gcgaagaaga ucauugauac ccgaagguau caaugaucuu cuucgcuuuu uu               52


<210>  56
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  56
gcaaaucgcc aaggagauug gcgaaccaau cuccuuggcg auuugcuuuu uu               52


<210>  57
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  57
gcacagcucc augaaccaaa ucgaaauuug guucauggag cugugcuuuu uu               52


<210>  58
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  58
ggaccuucau ucaauccauc acgaaugaug gauugaauga agguccuuuu uu               52


<210>  59
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short hairpin RNA (shRNA)

<400>  59
ggaagaaguu caucaacaau ccgaagauug uugaugaacu ucuuccuuuu uu               52


<210>  60
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sRGN protein sequence

<400>  60

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
65                  70                  75                  80  


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Asn Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
                245                 250                 255     


Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile 
            260                 265                 270         


Gln Arg Asp Asn Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
    290                 295                 300                 


Ala Lys Glu Ile Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile 
305                 310                 315                 320 


Thr Lys Ser Gly Thr Pro Glu Phe Thr Ser Phe Lys Leu Phe His Asp 
                325                 330                 335     


Leu Lys Lys Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu 
            340                 345                 350         


Leu Asn Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser 
        355                 360                 365             


Ile Val Ala Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp 
    370                 375                 380                 


Lys Gln Ser Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser 
                405                 410                 415     


Met Asn Gln Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys 
            420                 425                 430         


Tyr Glu Leu Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp 
        435                 440                 445             


Ala Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
    530                 535                 540                 


Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn 
                565                 570                 575     


Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln 
        595                 600                 605             


Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser 
    610                 615                 620                 


Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Asn Tyr Arg Phe Asp Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val 
        915                 920                 925             


Thr Ile Ala Tyr Leu Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Lys Asp Lys Tyr Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp 
945                 950                 955                 960 


Thr Asp Gln Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asn Gly Asp Leu Tyr Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn 
            980                 985                 990         


Ile Ile Glu Leu Asp Tyr Tyr Asp  Ile Lys Tyr Lys Asp  Tyr Cys Glu 
        995                 1000                 1005             


Ile Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Thr Glu Ser Ile Glu  Lys Phe Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Leu  Tyr Leu His Ser Thr  Glu Lys Ala Pro Gln  Leu Ile Phe 
    1040                 1045                 1050             


Lys Arg  Gly Leu 
    1055         


<210>  61
<211>  3171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sRGN sequence

<400>  61
atgaaccaga agttcattct cggtctggac attggcatta ctagcgtggg atacggcttg       60

attgactacg agactaagaa catcatcgat gccggcgtcc gcctgttccc ggaagccaac      120

gtggagaaca atgagggccg gaggtcgaag agaggctccc gccgcctgaa gcggcggcga      180

atccaccggc tggagagagt gaagctgctg ctcaccgaat acgacctgat caacaaagaa      240

cagatcccga cctccaacaa cccgtaccag atcagagtga agggtctgtc agaaatcctg      300

tccaaggacg aactggcaat cgccctgctg cacctggcca agcggcgcgg aatccacaac      360

gtggatgtgg ctgccgacaa ggaagaaacc gcttccgact ccctgagcac taaggaccag      420

atcaacaaga acgccaagtt cttggagtcc cgctacgtgt gcgagctgca gaaggaacgg      480

ctggaaaacg aaggtcacgt gcgcggagtg gaaaaccggt tcctgacaaa ggacattgtg      540

cgcgaagcga agaagatcat tgatacccaa atgcagtact accctgaaat cgacgagact      600

ttcaaggaaa agtacatttc cctggtggaa acccggcggg aatacttcga aggccccgga      660

cagggatcgc cgttcggatg gaacggggac ctcaagaagt ggtacgagat gctgatgggg      720

cactgtacct actttccgca agaactgcgc tccgtgaagt acgcgtactc cgcggatctc      780

ttcaacgcgt tgaatgacct gaacaacctg atcattcaga gagacaattc cgaaaagctc      840

gagtaccacg agaagtatca catcatcgag aatgtgttca agcagaagaa gaaaccgacc      900

ctcaagcaaa tcgccaagga gattggcgtc aacccagagg acatcaaggg atatcggatt      960

accaagagcg gcactcccga gtttacctct ttcaagctgt ttcatgatct gaagaaagtc     1020

gtgaaggacc atgccattct cgacgacatt gatctcctga atcagatcgc agagatcctg     1080

actatctacc aagacaagga ctcgattgtg gcagagctgg gtcagctcga atacctgatg     1140

tccgaggccg acaagcagtc catctccgaa ctgacagggt acacggggac tcatagcctg     1200

tcgctgaagt gcatgaacat gatcattgat gaactgtggc acagctccat gaaccaaatg     1260

gaagtgttta cctacctcaa catgcgccct aagaagtacg aactgaaagg ctaccagcgc     1320

atccccaccg acatgatcga cgacgcgatc ttgtcccctg tggtcaagag gaccttcatt     1380

caatccatca acgtgatcaa caaggtcatc gaaaagtacg gaataccaga agatatcatc     1440

attgagctcg ctcgggagaa caactcggat gaccggaaga agttcatcaa caatcttcag     1500

aagaagaacg aagcgactcg gaaacggatc aacgagatca tcggacagac cggaaaccag     1560

aacgccaaac ggattgtcga aaagattaga ctgcacgacc agcaggaagg gaagtgcctg     1620

tactcactcg agtcaatacc gctcgaggac ctgttgaaca accctaacca ctatgaagtg     1680

gaccacatca tccctcggtc cgtgagcttc gacaactcgt accacaacaa agtgctcgtg     1740

aagcagtccg aaaactccaa gaaatccaac ctgaccccgt accaatactt caattcggga     1800

aagtcgaagc tgtcgtacaa ccagttcaaa caacacatac tcaaccttag caaaagccag     1860

gatcgcattt ccaagaagaa gaaggaatac ctcctcgagg aaagggacat caacaagttc     1920

gaagtgcaga aagagttcat caatcgcaac ttggtggata ccagatatgc cacccgggaa     1980

ctcaccaact atctcaaggc ctacttttcc gccaacaaca tgaacgtgaa ggtcaagacc     2040

atcaacgggt ccttcactga ctacctgaga aaggtctgga agttcaagaa ggaacgcaac     2100

cacggataca agcaccacgc tgaggacgct ctgatcatcg ccaatgccga cttcctgttc     2160

aaggaaaaca agaagctgaa agctgtcaac tcagtgctgg aaaagcctga aatcgagact     2220

aagcagctgg atatccaagt ggactctgag gacaactaca gcgagatgtt catcatccct     2280

aaacaagtgc aggatatcaa ggactttcgc aacttcaagt actcacaccg ggtggacaag     2340

aaaccgaata gacagctgat caacgacacg ttgtattcca cccggaagaa ggataactca     2400

acctacattg tgcagactat caaggatatc tacgccaaag ataacactac tctgaagaaa     2460

caattcgaca agtccccaga gaagttcctg atgtaccagc acgacccccg aacctttgag     2520

aagcttgaag tgatcatgaa gcagtacgcc aacgagaaga acccgctggc caagtaccat     2580

gaagaaaccg gagaatacct gaccaagtac agcaagaaga acaacggtcc cattgtcaag     2640

agcctgaagt acatcggcaa caagctggga tcccacctcg acgtgacaca tcagttcaag     2700

tcgtcgacta agaagcttgt gaagctgtca atcaagaact atagattcga cgtgtacttg     2760

accgaaaagg gatacaagtt cgtgaccata gcctatctga acgtgttcaa gaaagataac     2820

tactactaca tccccaagga caagtaccag gagctcaaag aaaagaagaa gatcaaagac     2880

accgaccagt tcattgcctc cttctacaag aacgacctga tcaaactgaa cggcgacctc     2940

tacaagatca ttggagtgaa cagcgatgac aggaacatca ttgagctgga ctactacgac     3000

atcaagtaca aggactactg cgagatcaac aacatcaagg gcgaaccccg gatcaagaaa     3060

actattggaa agaaaaccga gtccattgag aagttcacca ctgacgtgct gggaaacctt     3120

tacctccact ccaccgagaa ggcaccacaa ctgatcttca agcgcggcct g              3171


<210>  62
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TetR coding sequence

<400>  62
atgatgtccc gccttgataa atcaaaagta ataaacagtg ctcttgagct tctcaatgaa       60

gttggtatag aagggttgac gactcggaaa ttggcgcaaa aactcggtgt tgagcagcca      120

accttgtatt ggcatgttaa aaacaaacga gcactcctcg acgctttggc gatagagatg      180

ctggacaggc accacacgca tttctgtccc ctcgaaggag agtcatggca ggatttcctt      240

agaaataacg caaagtcctt cagatgtgcg ctgcttagtc accgcgacgg cgcaaaagtt      300

catctcggca ctaggccaac cgagaaacag tacgagactc tggagaacca actggcgttt      360

ttgtgtcaac agggttttag tctcgaaaat gcgctctatg ctctctctgc ggttggccat      420

ttcaccctcg gatgcgtact ggaagatcag gagcaccaag tggccaaaga agaacgggaa      480

acgccgacta cggacagcat gcctccgttg ctccggcaag ctatagagct cttcgatcac      540

caaggcgctg agccagcttt cttgttcgga ttggaactta ttatatgcgg gctcgaaaag      600

cagcttaaat gcgagtcagg ttaa                                             624


<210>  63
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR protein sequence

<400>  63

Met Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu 
1               5                   10                  15      


Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala 
            20                  25                  30          


Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn 
        35                  40                  45              


Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His 
    50                  55                  60                  


His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu 
65                  70                  75                  80  


Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp 
                85                  90                  95      


Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu 
            100                 105                 110         


Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu 
        115                 120                 125             


Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly 
    130                 135                 140                 


Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu 
145                 150                 155                 160 


Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu 
                165                 170                 175     


Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu 
            180                 185                 190         


Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly 
        195                 200                 205         


<210>  64
<211>  3156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SaCas9 DNA sequence

<400>  64
aagcggaact atatcctggg actggacatc ggaattacct ccgtgggata cggcatcatc       60

gattacgaga ctagggacgt gattgacgcc ggcgtgagac tctttaagga ggccaacgtg      120

gaaaacaacg aaggtcgcag atccaagcgg ggtgcaagac gcctgaagcg ccggaggaga      180

catcggatac agcgcgtgaa gaagctcctt ttcgactaca acctcctcac tgaccactcg      240

gaattgtccg gtatcaaccc ctacgaagcc cgcgtgaaag gcctgagcca gaagctgtcc      300

gaagaggagt ttagcgcagc cctgctgcac ctggctaagc gaaggggggt gcacaacgtg      360

aacgaggtgg aggaggacac tggcaacgaa ctgtccacca aggagcagat ttcacggaac      420

tcgaaggcgc tggaagagaa atatgtggcc gagctgcagc tggagaggct caagaaggat      480

ggcgaagtcc gggggagcat caatcgcttc aagacctcgg actacgtgaa ggaagccaaa      540

cagctgttga aggtgcagaa ggcctaccac caactggacc aatcattcat tgacacttac      600

atcgatctgc ttgaaaccag gcgcacctac tacgagggtc ctggagaagg cagccctttc      660

ggatggaagg acatcaagga gtggtatgag atgctgatgg gtcattgcac ctactttccg      720

gaagaactgc gctcagtgaa gtacgcgtac aacgctgacc tctacaacgc tctcaacgat      780

ctgaacaacc tcgtgatcac ccgggacgag aacgaaaagc tggagtacta cgaaaagttc      840

cagattatcg aaaacgtgtt caagcagaag aagaagccca ccctgaagca gattgcaaag      900

gagatccttg tgaacgagga ggatattaag ggctaccggg tcacctccac cgggaaacca      960

gagttcacta atctcaaggt gtaccatgac attaaggaca ttactgcccg caaggagatc     1020

attgaaaacg cggaactgct ggaccaaatc gcgaagatcc tgaccatcta tcagagctcc     1080

gaggatatcc aggaggaact tactaacctc aattccgagc tgacgcagga agaaatcgag     1140

caaattagca acctgaaggg ttacactgga acccacaacc tcagcttgaa agcgattaac     1200

cttattttgg atgaactttg gcacactaat gacaatcaga tcgccatttt caaccggctg     1260

aaactggtgc cgaagaaggt ggacctgagc caacagaagg aaatcccgac cacccttgtg     1320

gacgatttca tcctgtcacc tgtggtgaag aggagcttca tccagtcgat caaggtcatc     1380

aacgccatca taaagaagta cggccttccc aacgacatca tcatcgaact ggcccgcgag     1440

aagaactcca aagatgccca gaagatgatc aacgagatgc agaagcgaaa ccggcagacg     1500

aacgaacgga tcgaggagat catccggacc accgggaagg aaaacgcgaa gtacctgatc     1560

gagaaaatca agctgcatga tatgcaggaa gggaagtgtc tctactccct ggaggccatt     1620

ccgctggagg atttgctgaa caaccctttc aactacgaag tcgatcatat cattcctcgc     1680

tccgtgtcct tcgataactc cttcaacaat aaggtcctcg tgaagcagga ggagaactcg     1740

aagaagggca acagaacccc gttccagtac ctctcgtcgt ccgactccaa gatcagctac     1800

gaaactttca agaagcacat tctgaacctg gccaagggca aagggagaat tagcaagacc     1860

aagaaggaat acctcctgga agagagagac atcaaccgct tctcggtgca aaaggatttc     1920

atcaaccgca acctggtcga taccagatac gccaccaggg gactgatgaa cctcctgcgg     1980

tcctacttcc gggtcaacaa tctggacgtg aaggtcaaat ccatcaacgg gggctttact     2040

tctttcctgc gccggaagtg gaagttcaag aaggaacgga acaagggata caagcaccac     2100

gctgaagatg ccctgattat tgccaacgcc gacttcatct ttaaggaatg gaaaaagctg     2160

gacaaggcta agaaggtcat ggagaaccag atgttcgaag aaaagcaggc cgagtccatg     2220

cccgaaatcg aaaccgagca ggaatacaag gagatcttca tcacaccgca ccaaatcaag     2280

cacatcaagg acttcaagga ttacaagtac agccaccggg tggacaagaa gcctaacaga     2340

gagcttatca acgacaccct gtactccacg cgcaaggacg acaagggaaa cacattgatc     2400

gtgaacaacc tgaacggact gtatgacaag gacaatgaca aactgaagaa gctgatcaac     2460

aaatcgccgg aaaagctcct gatgtaccat cacgaccctc aaacctacca gaaactgaag     2520

ctcatcatgg agcagtacgg cgacgaaaag aatcccctgt acaaatacta cgaggagact     2580

ggaaattacc tgactaagta ctccaagaag gataacggcc ccgtgatcaa gaagattaag     2640

tactacggaa acaaactgaa cgcacatctc gacatcaccg atgattatcc aaactcccgc     2700

aacaaagtcg tgaagctctc cctcaaaccg taccgcttcg acgtgtacct ggataatggg     2760

gtgtacaagt tcgtgaccgt gaagaacctg gacgtcatta agaaggaaaa ctactacgaa     2820

gtgaactcaa agtgctacga ggaagccaag aagctcaaga agatcagcaa ccaggccgag     2880

ttcatcgcat cgttttacaa caatgacctc attaagatta atggagaact gtacagagtg     2940

atcggcgtga acaacgacct cctgaaccgg attgaagtga acatgatcga tattacctac     3000

cgggagtatc tggagaacat gaacgacaag cgcccaccga gaatcatcaa aactattgcc     3060

tccaagaccc aatccattaa gaaatactcc accgacatcc tgggcaacct gtacgaggtc     3120

aagtcgaaga agcaccccca gattatcaag aaggga                               3156


<210>  65
<211>  1052
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SaCas9 protein sequence

<400>  65

Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
65                  70                  75                  80  


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
            100                 105                 110         


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
        115                 120                 125             


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
    130                 135                 140                 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
145                 150                 155                 160 


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
                165                 170                 175     


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
            180                 185                 190         


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
        195                 200                 205             


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
    210                 215                 220                 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
                245                 250                 255     


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
            260                 265                 270         


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
        275                 280                 285             


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
    290                 295                 300                 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
305                 310                 315                 320 


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
                325                 330                 335     


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
            340                 345                 350         


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
        355                 360                 365             


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
    370                 375                 380                 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
                405                 410                 415     


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
            420                 425                 430         


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
        435                 440                 445             


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
    450                 455                 460                 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
                485                 490                 495     


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
            500                 505                 510         


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
        515                 520                 525             


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
    530                 535                 540                 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
545                 550                 555                 560 


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
                565                 570                 575     


Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser 
            580                 585                 590         


Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile Leu 
        595                 600                 605             


Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr 
    610                 615                 620                 


Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp Phe 
625                 630                 635                 640 


Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met 
                645                 650                 655     


Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys Val 
            660                 665                 670         


Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys 
        675                 680                 685             


Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
    690                 695                 700                 


Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu 
705                 710                 715                 720 


Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys Gln 
                725                 730                 735     


Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile 
            740                 745                 750         


Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp Tyr 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu Ile 
785                 790                 795                 800 


Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu Lys 
                805                 810                 815     


Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His Asp 
            820                 825                 830         


Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile Lys 
865                 870                 875                 880 


Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp Tyr 
                885                 890                 895     


Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val Lys 
        915                 920                 925             


Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser Lys 
    930                 935                 940                 


Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala Glu 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly Glu 
                965                 970                 975     


Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile Glu 
            980                 985                 990         


Val Asn Met Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
        995                 1000                 1005             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1010                 1015                 1020             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1040                 1045                 1050         


<210>  66
<211>  4557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence packaged from pSIA111 and pSIA121

<400>  66
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgacg ggtgtggtac gcagccactg tttaagtact ctgtgctgga aacagcacag     4320

aatctactta aacaaggcaa aatgccgtgt ttatctcgtc aacttgttgg cgagattttt     4380

tcacgtgcgg accgaggctg cagcgtcgtc ctccctagga acccctagtg atggagttgg     4440

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     4500

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcagg        4557


<210>  67
<211>  4640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence packaged from pSIA142 and pSIA119

<400>  67
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggtctcccag gggcttccca      360

gtggtcccca ggaaccctcg acagggcccg gtctctctcg tccagcaagg gcagggacgg      420

gccacaggcc aagggcgcta gctaactacc ggtgccacca tggccccaaa gaagaagcgg      480

aaggtcggta gtactgtggg tactcgaagt ggctgcgtac cacacccgtc gcatggatcc      540

aagcggaact atatcctggg actggacatc ggaattacct ccgtgggata cggcatcatc      600

gattacgaga ctagggacgt gattgacgcc ggcgtgagac tctttaagga ggccaacgtg      660

gaaaacaacg aaggtcgcag atccaagcgg ggtgcaagac gcctgaagcg ccggaggaga      720

catcggatac agcgcgtgaa gaagctcctt ttcgactaca acctcctcac tgaccactcg      780

gaattgtccg gtatcaaccc ctacgaagcc cgcgtgaaag gcctgagcca gaagctgtcc      840

gaagaggagt ttagcgcagc cctgctgcac ctggctaagc gaaggggggt gcacaacgtg      900

aacgaggtgg aggaggacac tggcaacgaa ctgtccacca aggagcagat ttcacggaac      960

tcgaaggcgc tggaagagaa atatgtggcc gagctgcagc tggagaggct caagaaggat     1020

ggcgaagtcc gggggagcat caatcgcttc aagacctcgg actacgtgaa ggaagccaaa     1080

cagctgttga aggtgcagaa ggcctaccac caactggacc aatcattcat tgacacttac     1140

atcgatctgc ttgaaaccag gcgcacctac tacgagggtc ctggagaagg cagccctttc     1200

ggatggaagg acatcaagga gtggtatgag atgctgatgg gtcattgcac ctactttccg     1260

gaagaactgc gctcagtgaa gtacgcgtac aacgctgacc tctacaacgc tctcaacgat     1320

ctgaacaacc tcgtgatcac ccgggacgag aacgaaaagc tggagtacta cgaaaagttc     1380

cagattatcg aaaacgtgtt caagcagaag aagaagccca ccctgaagca gattgcaaag     1440

gagatccttg tgaacgagga ggatattaag ggctaccggg tcacctccac cgggaaacca     1500

gagttcacta atctcaaggt gtaccatgac attaaggaca ttactgcccg caaggagatc     1560

attgaaaacg cggaactgct ggaccaaatc gcgaagatcc tgaccatcta tcagagctcc     1620

gaggatatcc aggaggaact tactaacctc aattccgagc tgacgcagga agaaatcgag     1680

caaattagca acctgaaggg ttacactgga acccacaacc tcagcttgaa agcgattaac     1740

cttattttgg atgaactttg gcacactaat gacaatcaga tcgccatttt caaccggctg     1800

aaactggtgc cgaagaaggt ggacctgagc caacagaagg aaatcccgac cacccttgtg     1860

gacgatttca tcctgtcacc tgtggtgaag aggagcttca tccagtcgat caaggtcatc     1920

aacgccatca taaagaagta cggccttccc aacgacatca tcatcgaact ggcccgcgag     1980

aagaactcca aagatgccca gaagatgatc aacgagatgc agaagcgaaa ccggcagacg     2040

aacgaacgga tcgaggagat catccggacc accgggaagg aaaacgcgaa gtacctgatc     2100

gagaaaatca agctgcatga tatgcaggaa gggaagtgtc tctactccct ggaggccatt     2160

ccgctggagg atttgctgaa caaccctttc aactacgaag tcgatcatat cattcctcgc     2220

tccgtgtcct tcgataactc cttcaacaat aaggtcctcg tgaagcagga ggagaagtaa     2280

gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggctcg agaatgcgac     2340

gggtgtggta cgcagccact tcgagtaccc acagtactac ctgcttgtcg agacagagaa     2400

gactcttgcg tttctgatag gcacctattg gtcttactga catccacttt gcctttctct     2460

ccacagctcg aagaagggca acagaacccc gttccagtac ctctcgtcgt ccgactccaa     2520

gatcagctac gaaactttca agaagcacat tctgaacctg gccaagggca aagggagaat     2580

tagcaagacc aagaaggaat acctcctgga agagagagac atcaaccgct tctcggtgca     2640

aaaggatttc atcaaccgca acctggtcga taccagatac gccaccaggg gactgatgaa     2700

cctcctgcgg tcctacttcc gggtcaacaa tctggacgtg aaggtcaaat ccatcaacgg     2760

gggctttact tctttcctgc gccggaagtg gaagttcaag aaggaacgga acaagggata     2820

caagcaccac gctgaagatg ccctgattat tgccaacgcc gacttcatct ttaaggaatg     2880

gaaaaagctg gacaaggcta agaaggtcat ggagaaccag atgttcgaag aaaagcaggc     2940

cgagtccatg cccgaaatcg aaaccgagca ggaatacaag gagatcttca tcacaccgca     3000

ccaaatcaag cacatcaagg acttcaagga ttacaagtac agccaccggg tggacaagaa     3060

gcctaacaga gagcttatca acgacaccct gtactccacg cgcaaggacg acaagggaaa     3120

cacattgatc gtgaacaacc tgaacggact gtatgacaag gacaatgaca aactgaagaa     3180

gctgatcaac aaatcgccgg aaaagctcct gatgtaccat cacgaccctc aaacctacca     3240

gaaactgaag ctcatcatgg agcagtacgg cgacgaaaag aatcccctgt acaaatacta     3300

cgaggagact ggaaattacc tgactaagta ctccaagaag gataacggcc ccgtgatcaa     3360

gaagattaag tactacggaa acaaactgaa cgcacatctc gacatcaccg atgattatcc     3420

aaactcccgc aacaaagtcg tgaagctctc cctcaaaccg taccgcttcg acgtgtacct     3480

ggataatggg gtgtacaagt tcgtgaccgt gaagaacctg gacgtcatta agaaggaaaa     3540

ctactacgaa gtgaactcaa agtgctacga ggaagccaag aagctcaaga agatcagcaa     3600

ccaggccgag ttcatcgcat cgttttacaa caatgacctc attaagatta atggagaact     3660

gtacagagtg atcggcgtga acaacgacct cctgaaccgg attgaagtga acatgatcga     3720

tattacctac cgggagtatc tggagaacat gaacgacaag cgcccaccga gaatcatcaa     3780

aactattgcc tccaagaccc aatccattaa gaaatactcc accgacatcc tgggcaacct     3840

gtacgaggtc aagtcgaaga agcaccccca gattatcaag aagggaaaaa ggccggcggc     3900

cacgaaaaag gccggccagg caaaaaagaa aaaggcttaa gaattcctag agctcgctga     3960

tcagcctcga aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     4020

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     4080

caatgtatct tatcatgtct gtataccagc aggctttcct aggttcgaac gctgacgtca     4140

tcaacccgct ccaaggaatc gcgggcccag tgtcactagg cgggaacacc cagcgcgcgt     4200

gcgccctggc aggaagatgg ctgtgaggga caggggagtg gcgccctgca atatttgcat     4260

gtcgctatgt gttctgggaa atcaccataa acgtgaaatc cctatcagtg atagagactt     4320

ataagttccc tatcagtgat agagacaccg acgggtgtgg tacgcagcca ctgtttaagt     4380

actctgtgct ggaaacagca cagaatctac ttaaacaagg caaaatgccg tgtttatctc     4440

gtcaacttgt tggcgagatt ttttcacgtg cggaccgagg ctgcagcgtc gtcctcccta     4500

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4560

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     4620

agcgcgcagc tgcctgcagg                                                 4640


<210>  68
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence packaged from pSIA185-pSIA187 and pSIA036

<400>  68
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgggccc cagaagcctg gtggttgttt gtccttctca      180

ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaatgatct aatcggattc      240

caagcagctc aggggattgt ctttttctag caccttcttg ccactcctaa gcgtcctccg      300

tgaccccggc tgggatttag cctggtgctg tgtcagcccc ggctagctaa ctaccggtgc      360

caccatggcc ccaaagaaga agcggaaggt cggtagtact gtgggtactc gaagtggctg      420

cgtaccacac ccgtcgcatg gatccaagcg gaactatatc ctgggactgg acatcggaat      480

tacctccgtg ggatacggca tcatcgatta cgagactagg gacgtgattg acgccggcgt      540

gagactcttt aaggaggcca acgtggaaaa caacgaaggt cgcagatcca agcggggtgc      600

aagacgcctg aagcgccgga ggagacatcg gatacagcgc gtgaagaagc tccttttcga      660

ctacaacctc ctcactgacc actcggaatt gtccggtatc aacccctacg aagcccgcgt      720

gaaaggcctg agccagaagc tgtccgaaga ggagtttagc gcagccctgc tgcacctggc      780

taagcgaagg ggggtgcaca acgtgaacga ggtggaggag gacactggca acgaactgtc      840

caccaaggag cagatttcac ggaactcgaa ggcgctggaa gagaaatatg tggccgagct      900

gcagctggag aggctcaaga aggatggcga agtccggggg agcatcaatc gcttcaagac      960

ctcggactac gtgaaggaag ccaaacagct gttgaaggtg cagaaggcct accaccaact     1020

ggaccaatca ttcattgaca cttacatcga tctgcttgaa accaggcgca cctactacga     1080

gggtcctgga gaaggcagcc ctttcggatg gaaggacatc aaggagtggt atgagatgct     1140

gatgggtcat tgcacctact ttccggaaga actgcgctca gtgaagtacg cgtacaacgc     1200

tgacctctac aacgctctca acgatctgaa caacctcgtg atcacccggg acgagaacga     1260

aaagctggag tactacgaaa agttccagat tatcgaaaac gtgttcaagc agaagaagaa     1320

gcccaccctg aagcagattg caaaggagat ccttgtgaac gaggaggata ttaagggcta     1380

ccgggtcacc tccaccggga aaccagagtt cactaatctc aaggtgtacc atgacattaa     1440

ggacattact gcccgcaagg agatcattga aaacgcggaa ctgctggacc aaatcgcgaa     1500

gatcctgacc atctatcaga gctccgagga tatccaggag gaacttacta acctcaattc     1560

cgagctgacg caggaagaaa tcgagcaaat tagcaacctg aagggttaca ctggaaccca     1620

caacctcagc ttgaaagcga ttaaccttat tttggatgaa ctttggcaca ctaatgacaa     1680

tcagatcgcc attttcaacc ggctgaaact ggtgccgaag aaggtggacc tgagccaaca     1740

gaaggaaatc ccgaccaccc ttgtggacga tttcatcctg tcacctgtgg tgaagaggag     1800

cttcatccag tcgatcaagg tcatcaacgc catcataaag aagtacggcc ttcccaacga     1860

catcatcatc gaactggccc gcgagaagaa ctccaaagat gcccagaaga tgatcaacga     1920

gatgcagaag cgaaaccggc agacgaacga acggatcgag gagatcatcc ggaccaccgg     1980

gaaggaaaac gcgaagtacc tgatcgagaa aatcaagctg catgatatgc aggaagggaa     2040

gtgtctctac tccctggagg ccattccgct ggaggatttg ctgaacaacc ctttcaacta     2100

cgaagtcgat catatcattc ctcgctccgt gtccttcgat aactccttca acaataaggt     2160

cctcgtgaag caggaggaga agtaagtatc aaggttacaa gacaggttta aggagaccaa     2220

tagaaactgg gctcgagaat gcgacgggtg tggtacgcag ccacttcgag tacccacagt     2280

actacctgct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     2340

actgacatcc actttgcctt tctctccaca gctcgaagaa gggcaacaga accccgttcc     2400

agtacctctc gtcgtccgac tccaagatca gctacgaaac tttcaagaag cacattctga     2460

acctggccaa gggcaaaggg agaattagca agaccaagaa ggaatacctc ctggaagaga     2520

gagacatcaa ccgcttctcg gtgcaaaagg atttcatcaa ccgcaacctg gtcgatacca     2580

gatacgccac caggggactg atgaacctcc tgcggtccta cttccgggtc aacaatctgg     2640

acgtgaaggt caaatccatc aacgggggct ttacttcttt cctgcgccgg aagtggaagt     2700

tcaagaagga acggaacaag ggatacaagc accacgctga agatgccctg attattgcca     2760

acgccgactt catctttaag gaatggaaaa agctggacaa ggctaagaag gtcatggaga     2820

accagatgtt cgaagaaaag caggccgagt ccatgcccga aatcgaaacc gagcaggaat     2880

acaaggagat cttcatcaca ccgcaccaaa tcaagcacat caaggacttc aaggattaca     2940

agtacagcca ccgggtggac aagaagccta acagagagct tatcaacgac accctgtact     3000

ccacgcgcaa ggacgacaag ggaaacacat tgatcgtgaa caacctgaac ggactgtatg     3060

acaaggacaa tgacaaactg aagaagctga tcaacaaatc gccggaaaag ctcctgatgt     3120

accatcacga ccctcaaacc taccagaaac tgaagctcat catggagcag tacggcgacg     3180

aaaagaatcc cctgtacaaa tactacgagg agactggaaa ttacctgact aagtactcca     3240

agaaggataa cggccccgtg atcaagaaga ttaagtacta cggaaacaaa ctgaacgcac     3300

atctcgacat caccgatgat tatccaaact cccgcaacaa agtcgtgaag ctctccctca     3360

aaccgtaccg cttcgacgtg tacctggata atggggtgta caagttcgtg accgtgaaga     3420

acctggacgt cattaagaag gaaaactact acgaagtgaa ctcaaagtgc tacgaggaag     3480

ccaagaagct caagaagatc agcaaccagg ccgagttcat cgcatcgttt tacaacaatg     3540

acctcattaa gattaatgga gaactgtaca gagtgatcgg cgtgaacaac gacctcctga     3600

accggattga agtgaacatg atcgatatta cctaccggga gtatctggag aacatgaacg     3660

acaagcgccc accgagaatc atcaaaacta ttgcctccaa gacccaatcc attaagaaat     3720

actccaccga catcctgggc aacctgtacg aggtcaagtc gaagaagcac ccccagatta     3780

tcaagaaggg aaaaaggccg gcggccacga aaaaggccgg ccaggcaaaa aagaaaaagg     3840

cttaagaatt cctagagctc gctgatcagc ctcgaaactt gtttattgca gcttataatg     3900

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     3960

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccagcaggct     4020

ttcctaggtt cgaacgctga cgtcatcaac ccgctccaag gaatcgcggg cccagtgtca     4080

ctaggcggga acacccagcg cgcgtgcgcc ctggcaggaa gatggctgtg agggacaggg     4140

gagtggcgcc ctgcaatatt tgcatgtcgc tatgtgttct gggaaatcac cataaacgtg     4200

aaatccctat cagtgataga gacttataag ttccctatca gtgatagaga caccgggtgt     4260

ggtacgcagc cactgtttaa gtactctgtg ctggaaacag cacagaatct acttaaacaa     4320

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga ttttttcacg tgcggaccga     4380

ggctgcagcg tcgtcctccc taggaacccc tagtgatgga gttggccact ccctctctgc     4440

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4500

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca gg                        4542


<210>  69
<211>  4554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence packaged from pSIA069, pSIA188-pSIA190

<400>  69
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgctccg gtgcccgtca gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgctagct      360

aactaccggt gccaccatgg ccccaaagaa gaagcggaag gtcggtagta ctgtgggtac      420

tcgaagtggc tgcgtaccac acccgtcgca tggatccaag cggaactata tcctgggact      480

ggacatcgga attacctccg tgggatacgg catcatcgat tacgagacta gggacgtgat      540

tgacgccggc gtgagactct ttaaggaggc caacgtggaa aacaacgaag gtcgcagatc      600

caagcggggt gcaagacgcc tgaagcgccg gaggagacat cggatacagc gcgtgaagaa      660

gctccttttc gactacaacc tcctcactga ccactcggaa ttgtccggta tcaaccccta      720

cgaagcccgc gtgaaaggcc tgagccagaa gctgtccgaa gaggagttta gcgcagccct      780

gctgcacctg gctaagcgaa ggggggtgca caacgtgaac gaggtggagg aggacactgg      840

caacgaactg tccaccaagg agcagatttc acggaactcg aaggcgctgg aagagaaata      900

tgtggccgag ctgcagctgg agaggctcaa gaaggatggc gaagtccggg ggagcatcaa      960

tcgcttcaag acctcggact acgtgaagga agccaaacag ctgttgaagg tgcagaaggc     1020

ctaccaccaa ctggaccaat cattcattga cacttacatc gatctgcttg aaaccaggcg     1080

cacctactac gagggtcctg gagaaggcag ccctttcgga tggaaggaca tcaaggagtg     1140

gtatgagatg ctgatgggtc attgcaccta ctttccggaa gaactgcgct cagtgaagta     1200

cgcgtacaac gctgacctct acaacgctct caacgatctg aacaacctcg tgatcacccg     1260

ggacgagaac gaaaagctgg agtactacga aaagttccag attatcgaaa acgtgttcaa     1320

gcagaagaag aagcccaccc tgaagcagat tgcaaaggag atccttgtga acgaggagga     1380

tattaagggc taccgggtca cctccaccgg gaaaccagag ttcactaatc tcaaggtgta     1440

ccatgacatt aaggacatta ctgcccgcaa ggagatcatt gaaaacgcgg aactgctgga     1500

ccaaatcgcg aagatcctga ccatctatca gagctccgag gatatccagg aggaacttac     1560

taacctcaat tccgagctga cgcaggaaga aatcgagcaa attagcaacc tgaagggtta     1620

cactggaacc cacaacctca gcttgaaagc gattaacctt attttggatg aactttggca     1680

cactaatgac aatcagatcg ccattttcaa ccggctgaaa ctggtgccga agaaggtgga     1740

cctgagccaa cagaaggaaa tcccgaccac ccttgtggac gatttcatcc tgtcacctgt     1800

ggtgaagagg agcttcatcc agtcgatcaa ggtcatcaac gccatcataa agaagtacgg     1860

ccttcccaac gacatcatca tcgaactggc ccgcgagaag aactccaaag atgcccagaa     1920

gatgatcaac gagatgcaga agcgaaaccg gcagacgaac gaacggatcg aggagatcat     1980

ccggaccacc gggaaggaaa acgcgaagta cctgatcgag aaaatcaagc tgcatgatat     2040

gcaggaaggg aagtgtctct actccctgga ggccattccg ctggaggatt tgctgaacaa     2100

ccctttcaac tacgaagtcg atcatatcat tcctcgctcc gtgtccttcg ataactcctt     2160

caacaataag gtcctcgtga agcaggagga gaagtaagta tcaaggttac aagacaggtt     2220

taaggagacc aatagaaact gggctcgaga atgcgacggg tgtggtacgc agccacttcg     2280

agtacccaca gtactacctg cttgtcgaga cagagaagac tcttgcgttt ctgataggca     2340

cctattggtc ttactgacat ccactttgcc tttctctcca cagctcgaag aagggcaaca     2400

gaaccccgtt ccagtacctc tcgtcgtccg actccaagat cagctacgaa actttcaaga     2460

agcacattct gaacctggcc aagggcaaag ggagaattag caagaccaag aaggaatacc     2520

tcctggaaga gagagacatc aaccgcttct cggtgcaaaa ggatttcatc aaccgcaacc     2580

tggtcgatac cagatacgcc accaggggac tgatgaacct cctgcggtcc tacttccggg     2640

tcaacaatct ggacgtgaag gtcaaatcca tcaacggggg ctttacttct ttcctgcgcc     2700

ggaagtggaa gttcaagaag gaacggaaca agggatacaa gcaccacgct gaagatgccc     2760

tgattattgc caacgccgac ttcatcttta aggaatggaa aaagctggac aaggctaaga     2820

aggtcatgga gaaccagatg ttcgaagaaa agcaggccga gtccatgccc gaaatcgaaa     2880

ccgagcagga atacaaggag atcttcatca caccgcacca aatcaagcac atcaaggact     2940

tcaaggatta caagtacagc caccgggtgg acaagaagcc taacagagag cttatcaacg     3000

acaccctgta ctccacgcgc aaggacgaca agggaaacac attgatcgtg aacaacctga     3060

acggactgta tgacaaggac aatgacaaac tgaagaagct gatcaacaaa tcgccggaaa     3120

agctcctgat gtaccatcac gaccctcaaa cctaccagaa actgaagctc atcatggagc     3180

agtacggcga cgaaaagaat cccctgtaca aatactacga ggagactgga aattacctga     3240

ctaagtactc caagaaggat aacggccccg tgatcaagaa gattaagtac tacggaaaca     3300

aactgaacgc acatctcgac atcaccgatg attatccaaa ctcccgcaac aaagtcgtga     3360

agctctccct caaaccgtac cgcttcgacg tgtacctgga taatggggtg tacaagttcg     3420

tgaccgtgaa gaacctggac gtcattaaga aggaaaacta ctacgaagtg aactcaaagt     3480

gctacgagga agccaagaag ctcaagaaga tcagcaacca ggccgagttc atcgcatcgt     3540

tttacaacaa tgacctcatt aagattaatg gagaactgta cagagtgatc ggcgtgaaca     3600

acgacctcct gaaccggatt gaagtgaaca tgatcgatat tacctaccgg gagtatctgg     3660

agaacatgaa cgacaagcgc ccaccgagaa tcatcaaaac tattgcctcc aagacccaat     3720

ccattaagaa atactccacc gacatcctgg gcaacctgta cgaggtcaag tcgaagaagc     3780

acccccagat tatcaagaag ggaaaaaggc cggcggccac gaaaaaggcc ggccaggcaa     3840

aaaagaaaaa ggcttaagaa ttcctagagc tcgctgatca gcctcgaaac ttgtttattg     3900

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3960

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     4020

taccagcagg ctttcctagg ttcgaacgct gacgtcatca acccgctcca aggaatcgcg     4080

ggcccagtgt cactaggcgg gaacacccag cgcgcgtgcg ccctggcagg aagatggctg     4140

tgagggacag gggagtggcg ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc     4200

accataaacg tgaaatccct atcagtgata gagacttata agttccctat cagtgataga     4260

gacaccgggt gtggtacgca gccactgttt aagtactctg tgctggaaac agcacagaat     4320

ctacttaaac aaggcaaaat gccgtgttta tctcgtcaac ttgttggcga gattttttca     4380

cgtgcggacc gaggctgcag cgtcgtcctc cctaggaacc cctagtgatg gagttggcca     4440

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4500

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg cagg           4554


