                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> METHODS FOR PREPARATION OF ACTIVE SEPARASE

<130> 081906-1191728-231610WO

<140>
<141>

<150> 62/865,611
<151> 2019-06-24

<160> 37    

<170> PatentIn version 3.5

<210> 1
<211> 2120
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln 
1               5                   10                  15      


Lys Glu Ala Glu Glu Leu Leu Pro Asp Leu Lys Glu Phe Leu Ser Asn 
            20                  25                  30          


Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln 
        35                  40                  45              


Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys 
    50                  55                  60                  


Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu 
65                  70                  75                  80  


Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr 
                85                  90                  95      


Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly 
            100                 105                 110         


Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 
        115                 120                 125             


Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala 
    130                 135                 140                 


Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu 
145                 150                 155                 160 


Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val 
                165                 170                 175     


Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser 
            180                 185                 190         


Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser 
        195                 200                 205             


Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu 
    210                 215                 220                 


Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser 
225                 230                 235                 240 


Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu 
                245                 250                 255     


Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile 
            260                 265                 270         


Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly 
    290                 295                 300                 


Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala 
305                 310                 315                 320 


Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 
                325                 330                 335     


Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys 
            340                 345                 350         


Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 
        355                 360                 365             


Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly 
    370                 375                 380                 


Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly 
385                 390                 395                 400 


Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln 
                405                 410                 415     


Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser 
            420                 425                 430         


Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu 
        435                 440                 445             


Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala 
    450                 455                 460                 


Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser 
465                 470                 475                 480 


Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro 
                485                 490                 495     


Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu 
            500                 505                 510         


Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile 
        515                 520                 525             


Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu 
    530                 535                 540                 


Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly 
545                 550                 555                 560 


Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp 
                565                 570                 575     


Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr 
            580                 585                 590         


Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys 
        595                 600                 605             


Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala 
    610                 615                 620                 


Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp 
625                 630                 635                 640 


Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala 
                645                 650                 655     


Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln 
            660                 665                 670         


Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr 
        675                 680                 685             


Leu Glu Ala Lys Ile Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln 
    690                 695                 700                 


Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu 
705                 710                 715                 720 


Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn 
                725                 730                 735     


Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala 
            740                 745                 750         


Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys 
        755                 760                 765             


Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln 
    770                 775                 780                 


Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg 
785                 790                 795                 800 


Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser 
                805                 810                 815     


Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala 
            820                 825                 830         


Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln 
        835                 840                 845             


Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg 
    850                 855                 860                 


Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu 
865                 870                 875                 880 


Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala 
                885                 890                 895     


Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu 
            900                 905                 910         


Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys 
        915                 920                 925             


Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys 
    930                 935                 940                 


Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser 
945                 950                 955                 960 


Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn 
                965                 970                 975     


Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu 
            980                 985                 990         


Lys Leu Val Cys His Leu Gly Arg  Leu Gly Ser Val Ser  Glu Ala Lys 
        995                 1000                 1005             


Ala Phe  Cys Leu Glu Ala Leu  Lys Leu Thr Thr Lys  Leu Gln Ile 
    1010                 1015                 1020             


Pro Arg  Gln Cys Ala Leu Phe  Leu Val Leu Lys Gly  Glu Leu Glu 
    1025                 1030                 1035             


Leu Ala  Arg Asn Asp Ile Asp  Leu Cys Gln Ser Asp  Leu Gln Gln 
    1040                 1045                 1050             


Val Leu  Phe Leu Leu Glu Ser  Cys Thr Glu Phe Gly  Gly Val Thr 
    1055                 1060                 1065             


Gln His  Leu Asp Ser Val Lys  Lys Val His Leu Gln  Lys Gly Lys 
    1070                 1075                 1080             


Gln Gln  Ala Gln Val Pro Cys  Pro Pro Gln Leu Pro  Glu Glu Glu 
    1085                 1090                 1095             


Leu Phe  Leu Arg Gly Pro Ala  Leu Glu Leu Val Ala  Thr Val Ala 
    1100                 1105                 1110             


Lys Glu  Pro Gly Pro Ile Ala  Pro Ser Thr Asn Ser  Ala Pro Val 
    1115                 1120                 1125             


Leu Lys  Thr Lys Pro Gln Pro  Ile Pro Asn Phe Leu  Ser His Ser 
    1130                 1135                 1140             


Pro Thr  Cys Asp Cys Ser Leu  Cys Ala Ser Pro Val  Leu Thr Ala 
    1145                 1150                 1155             


Val Cys  Leu Arg Trp Val Leu  Val Thr Ala Gly Val  Arg Leu Ala 
    1160                 1165                 1170             


Met Gly  His Gln Ala Gln Gly  Leu Asp Leu Leu Gln  Val Val Leu 
    1175                 1180                 1185             


Lys Gly  Cys Pro Glu Ala Ala  Glu Arg Leu Thr Gln  Ala Leu Gln 
    1190                 1195                 1200             


Ala Ser  Leu Asn His Lys Thr  Pro Pro Ser Leu Val  Pro Ser Leu 
    1205                 1210                 1215             


Leu Asp  Glu Ile Leu Ala Gln  Ala Tyr Thr Leu Leu  Ala Leu Glu 
    1220                 1225                 1230             


Gly Leu  Asn Gln Pro Ser Asn  Glu Ser Leu Gln Lys  Val Leu Gln 
    1235                 1240                 1245             


Ser Gly  Leu Lys Phe Val Ala  Ala Arg Ile Pro His  Leu Glu Pro 
    1250                 1255                 1260             


Trp Arg  Ala Ser Leu Leu Leu  Ile Trp Ala Leu Thr  Lys Leu Gly 
    1265                 1270                 1275             


Gly Leu  Ser Cys Cys Thr Thr  Gln Leu Phe Ala Ser  Ser Trp Gly 
    1280                 1285                 1290             


Trp Gln  Pro Pro Leu Ile Lys  Ser Val Pro Gly Ser  Glu Pro Ser 
    1295                 1300                 1305             


Lys Thr  Gln Gly Gln Lys Arg  Ser Gly Arg Gly Arg  Gln Lys Leu 
    1310                 1315                 1320             


Ala Ser  Ala Pro Leu Ser Leu  Asn Asn Thr Ser Gln  Lys Gly Leu 
    1325                 1330                 1335             


Glu Gly  Arg Gly Leu Pro Cys  Thr Pro Lys Pro Pro  Asp Arg Ile 
    1340                 1345                 1350             


Arg Gln  Ala Gly Pro His Val  Pro Phe Thr Val Phe  Glu Glu Val 
    1355                 1360                 1365             


Cys Pro  Thr Glu Ser Lys Pro  Glu Val Pro Gln Ala  Pro Arg Val 
    1370                 1375                 1380             


Gln Gln  Arg Val Gln Thr Arg  Leu Lys Val Asn Phe  Ser Asp Asp 
    1385                 1390                 1395             


Ser Asp  Leu Glu Asp Pro Val  Ser Ala Glu Ala Trp  Leu Ala Glu 
    1400                 1405                 1410             


Glu Pro  Lys Arg Arg Gly Thr  Ala Ser Arg Gly Arg  Gly Arg Ala 
    1415                 1420                 1425             


Arg Lys  Gly Leu Ser Leu Lys  Thr Asp Ala Val Val  Ala Pro Gly 
    1430                 1435                 1440             


Ser Ala  Pro Gly Asn Pro Gly  Leu Asn Gly Arg Ser  Arg Arg Ala 
    1445                 1450                 1455             


Lys Lys  Val Ala Ser Arg His  Cys Glu Glu Arg Arg  Pro Gln Arg 
    1460                 1465                 1470             


Ala Ser  Asp Gln Ala Arg Pro  Gly Pro Arg Ile Met  Glu Thr Ile 
    1475                 1480                 1485             


Pro Glu  Glu Glu Leu Thr Asp  Asn Trp Arg Lys Met  Ser Phe Arg 
    1490                 1495                 1500             


Ile Leu  Glu Gly Ser Asp Gly  Glu Asp Ser Ala Ser  Gly Gly Lys 
    1505                 1510                 1515             


Thr Pro  Ala Pro Gly Pro Glu  Ala Ala Ser Gly Glu  Trp Arg Leu 
    1520                 1525                 1530             


Leu Glu  Leu Asp Ser Ser Lys  Lys Lys Leu Pro Ser  Pro Cys Pro 
    1535                 1540                 1545             


Asp Lys  Glu Ser Asp Lys Asp  Leu Gly Pro Arg Leu  Gln Leu Pro 
    1550                 1555                 1560             


Ser Ala  Pro Val Ala Thr Gly  Leu Ser Thr Leu Asp  Ser Ile Cys 
    1565                 1570                 1575             


Asp Ser  Leu Ser Val Ala Phe  Arg Gly Ile Ser His  Cys Pro Pro 
    1580                 1585                 1590             


Ser Gly  Leu Tyr Ala His Leu  Cys Arg Phe Leu Ala  Leu Cys Leu 
    1595                 1600                 1605             


Gly His  Arg Asp Pro Tyr Ala  Thr Ala Phe Leu Val  Thr Glu Ser 
    1610                 1615                 1620             


Val Ser  Ile Thr Cys Arg His  Gln Leu Leu Thr His  Leu His Arg 
    1625                 1630                 1635             


Gln Leu  Ser Lys Ala Gln Lys  His Arg Gly Ser Leu  Glu Ile Ala 
    1640                 1645                 1650             


Asp Gln  Leu Gln Gly Leu Ser  Leu Gln Glu Met Pro  Gly Asp Val 
    1655                 1660                 1665             


Pro Leu  Ala Arg Ile Gln Arg  Leu Phe Ser Phe Arg  Ala Leu Glu 
    1670                 1675                 1680             


Ser Gly  His Phe Pro Gln Pro  Glu Lys Glu Ser Phe  Gln Glu Arg 
    1685                 1690                 1695             


Leu Ala  Leu Ile Pro Ser Gly  Val Thr Val Cys Val  Leu Ala Leu 
    1700                 1705                 1710             


Ala Thr  Leu Gln Pro Gly Thr  Val Gly Asn Thr Leu  Leu Leu Thr 
    1715                 1720                 1725             


Arg Leu  Glu Lys Asp Ser Pro  Pro Val Ser Val Gln  Ile Pro Thr 
    1730                 1735                 1740             


Gly Gln  Asn Lys Leu His Leu  Arg Ser Val Leu Asn  Glu Phe Asp 
    1745                 1750                 1755             


Ala Ile  Gln Lys Ala Gln Lys  Glu Asn Ser Ser Cys  Thr Asp Lys 
    1760                 1765                 1770             


Arg Glu  Trp Trp Thr Gly Arg  Leu Ala Leu Asp His  Arg Met Glu 
    1775                 1780                 1785             


Val Leu  Ile Ala Ser Leu Glu  Lys Ser Val Leu Gly  Cys Trp Lys 
    1790                 1795                 1800             


Gly Leu  Leu Leu Pro Ser Ser  Glu Glu Pro Gly Pro  Ala Gln Glu 
    1805                 1810                 1815             


Ala Ser  Arg Leu Gln Glu Leu  Leu Gln Asp Cys Gly  Trp Lys Tyr 
    1820                 1825                 1830             


Pro Asp  Arg Thr Leu Leu Lys  Ile Met Leu Ser Gly  Ala Gly Ala 
    1835                 1840                 1845             


Leu Thr  Pro Gln Asp Ile Gln  Ala Leu Ala Tyr Gly  Leu Cys Pro 
    1850                 1855                 1860             


Thr Gln  Pro Glu Arg Ala Gln  Glu Leu Leu Asn Glu  Ala Val Gly 
    1865                 1870                 1875             


Arg Leu  Gln Gly Leu Thr Val  Pro Ser Asn Ser His  Leu Val Leu 
    1880                 1885                 1890             


Val Leu  Asp Lys Asp Leu Gln  Lys Leu Pro Trp Glu  Ser Met Pro 
    1895                 1900                 1905             


Ser Leu  Gln Ala Leu Pro Val  Thr Arg Leu Pro Ser  Phe Arg Phe 
    1910                 1915                 1920             


Leu Leu  Ser Tyr Ser Ile Ile  Lys Glu Tyr Gly Ala  Ser Pro Val 
    1925                 1930                 1935             


Leu Ser  Gln Gly Val Asp Pro  Arg Ser Thr Phe Tyr  Val Leu Asn 
    1940                 1945                 1950             


Pro His  Asn Asn Leu Ser Ser  Thr Glu Glu Gln Phe  Arg Ala Asn 
    1955                 1960                 1965             


Phe Ser  Ser Glu Ala Gly Trp  Arg Gly Val Val Gly  Glu Val Pro 
    1970                 1975                 1980             


Arg Pro  Glu Gln Val Gln Glu  Ala Leu Thr Lys His  Asp Leu Tyr 
    1985                 1990                 1995             


Ile Tyr  Ala Gly His Gly Ala  Gly Ala Arg Phe Leu  Asp Gly Gln 
    2000                 2005                 2010             


Ala Val  Leu Arg Leu Ser Cys  Arg Ala Val Ala Leu  Leu Phe Gly 
    2015                 2020                 2025             


Cys Ser  Ser Ala Ala Leu Ala  Val His Gly Asn Leu  Glu Gly Ala 
    2030                 2035                 2040             


Gly Ile  Val Leu Lys Tyr Ile  Met Ala Gly Cys Pro  Leu Phe Leu 
    2045                 2050                 2055             


Gly Asn  Leu Trp Asp Val Thr  Asp Arg Asp Ile Asp  Arg Tyr Thr 
    2060                 2065                 2070             


Glu Ala  Leu Leu Gln Gly Trp  Leu Gly Ala Gly Pro  Gly Ala Pro 
    2075                 2080                 2085             


Leu Leu  Tyr Tyr Val Asn Gln  Ala Arg Gln Ala Pro  Arg Leu Lys 
    2090                 2095                 2100             


Tyr Leu  Ile Gly Ala Ala Pro  Ile Ala Tyr Gly Leu  Pro Val Ser 
    2105                 2110                 2115             


Leu Arg  
    2120 


<210> 2
<211> 202
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Thr Leu Ile Tyr Val Asp Lys Glu Asn Gly Glu Pro Gly Thr 
1               5                   10                  15      


Arg Val Val Ala Lys Asp Gly Leu Lys Leu Gly Ser Gly Pro Ser Ile 
            20                  25                  30          


Lys Ala Leu Asp Gly Arg Ser Gln Val Ser Thr Pro Arg Phe Gly Lys 
        35                  40                  45              


Thr Phe Asp Ala Pro Pro Ala Leu Pro Lys Ala Thr Arg Lys Ala Leu 
    50                  55                  60                  


Gly Thr Val Asn Arg Ala Thr Glu Lys Ser Val Lys Thr Lys Gly Pro 
65                  70                  75                  80  


Leu Lys Gln Lys Gln Pro Ser Phe Ser Ala Lys Lys Met Thr Glu Lys 
                85                  90                  95      


Thr Val Lys Ala Lys Ser Ser Val Pro Ala Ser Asp Asp Ala Tyr Pro 
            100                 105                 110         


Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu Ser Phe 
        115                 120                 125             


Asp Leu Pro Glu Glu His Gln Ile Ala His Leu Pro Leu Ser Gly Val 
    130                 135                 140                 


Pro Leu Met Ile Leu Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln 
145                 150                 155                 160 


Leu Gly Pro Pro Ser Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser 
                165                 170                 175     


Asn Leu Leu Gln Ser Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu 
            180                 185                 190         


Leu Pro Pro Val Cys Cys Asp Ile Asp Ile 
        195                 200         


<210> 3
<211> 2321
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Thr Asn Thr Ala Lys Ile Leu Asn Phe Gly Arg Trp Ser His Pro 
1               5                   10                  15      


Gln Phe Glu Lys Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Ala Gly 
            20                  25                  30          


Trp Ser His Pro Gln Phe Glu Lys Gly Ser Ala Ser Met Thr Glu Lys 
        35                  40                  45              


Thr Val Lys Ala Lys Ser Ser Val Pro Ala Ser Asp Asp Ala Tyr Pro 
    50                  55                  60                  


Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu Ser Phe 
65                  70                  75                  80  


Asp Leu Pro Glu Glu His Gln Ile Ala His Leu Pro Leu Ser Gly Val 
                85                  90                  95      


Pro Leu Met Ile Leu Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln 
            100                 105                 110         


Leu Gly Pro Pro Ser Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser 
        115                 120                 125             


Asn Leu Leu Gln Ser Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu 
    130                 135                 140                 


Leu Pro Pro Val Cys Cys Asp Ile Asp Ile Gly Gly Ser Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Asn Leu Tyr Phe Gln Gly 
                165                 170                 175     


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
            180                 185                 190         


Lys Asp Asp Asp Asp Lys Ser Gly Pro Met Arg Ser Phe Lys Arg Val 
        195                 200                 205             


Asn Phe Gly Thr Leu Leu Ser Ser Gln Lys Glu Ala Glu Glu Leu Leu 
    210                 215                 220                 


Pro Asp Leu Lys Glu Phe Leu Ser Asn Pro Pro Ala Gly Phe Pro Ser 
225                 230                 235                 240 


Ser Arg Ser Asp Ala Glu Arg Arg Gln Ala Cys Asp Ala Ile Leu Arg 
                245                 250                 255     


Ala Cys Asn Gln Gln Leu Thr Ala Lys Leu Ala Cys Pro Arg His Leu 
            260                 265                 270         


Gly Ser Leu Leu Glu Leu Ala Glu Leu Ala Cys Asp Gly Tyr Leu Val 
        275                 280                 285             


Ser Thr Pro Gln Arg Pro Pro Leu Tyr Leu Glu Arg Ile Leu Phe Val 
    290                 295                 300                 


Leu Leu Arg Asn Ala Ala Ala Gln Gly Ser Pro Glu Ala Thr Leu Arg 
305                 310                 315                 320 


Leu Ala Gln Pro Leu His Ala Cys Leu Val Gln Cys Ser Arg Glu Ala 
                325                 330                 335     


Ala Pro Gln Asp Tyr Glu Ala Val Ala Arg Gly Ser Phe Ser Leu Leu 
            340                 345                 350         


Trp Lys Gly Ala Glu Ala Leu Leu Glu Arg Arg Ala Ala Phe Ala Ala 
        355                 360                 365             


Arg Leu Lys Ala Leu Ser Phe Leu Val Leu Leu Glu Asp Glu Ser Thr 
    370                 375                 380                 


Pro Cys Glu Val Pro His Phe Ala Ser Pro Thr Ala Cys Arg Ala Val 
385                 390                 395                 400 


Ala Ala His Gln Leu Phe Asp Ala Ser Gly His Gly Leu Asn Glu Ala 
                405                 410                 415     


Asp Ala Asp Phe Leu Asp Asp Leu Leu Ser Arg His Val Ile Arg Ala 
            420                 425                 430         


Leu Val Gly Glu Arg Gly Ser Ser Ser Gly Leu Leu Ser Pro Gln Arg 
        435                 440                 445             


Ala Leu Cys Leu Leu Glu Leu Thr Leu Glu His Cys Arg Arg Phe Cys 
    450                 455                 460                 


Trp Ser Arg His His Asp Lys Ala Ile Ser Ala Val Glu Lys Ala His 
465                 470                 475                 480 


Ser Tyr Leu Arg Asn Thr Asn Leu Ala Pro Ser Leu Gln Leu Cys Gln 
                485                 490                 495     


Leu Gly Val Lys Leu Leu Gln Val Gly Glu Glu Gly Pro Gln Ala Val 
            500                 505                 510         


Ala Lys Leu Leu Ile Lys Ala Ser Ala Val Leu Ser Lys Ser Met Glu 
        515                 520                 525             


Ala Pro Ser Pro Pro Leu Arg Ala Leu Tyr Glu Ser Cys Gln Phe Phe 
    530                 535                 540                 


Leu Ser Gly Leu Glu Arg Gly Thr Lys Arg Arg Tyr Arg Leu Asp Ala 
545                 550                 555                 560 


Ile Leu Ser Leu Phe Ala Phe Leu Gly Gly Tyr Cys Ser Leu Leu Gln 
                565                 570                 575     


Gln Leu Arg Asp Asp Gly Val Tyr Gly Gly Ser Ser Lys Gln Gln Gln 
            580                 585                 590         


Ser Phe Leu Gln Met Tyr Phe Gln Gly Leu His Leu Tyr Thr Val Val 
        595                 600                 605             


Val Tyr Asp Phe Ala Gln Gly Cys Gln Ile Val Asp Leu Ala Asp Leu 
    610                 615                 620                 


Thr Gln Leu Val Asp Ser Cys Lys Ser Thr Val Val Trp Met Leu Glu 
625                 630                 635                 640 


Ala Leu Glu Gly Leu Ser Gly Gln Glu Leu Thr Asp His Met Gly Met 
                645                 650                 655     


Thr Ala Ser Tyr Thr Ser Asn Leu Ala Tyr Ser Phe Tyr Ser His Lys 
            660                 665                 670         


Leu Tyr Ala Glu Ala Cys Ala Ile Ser Glu Pro Leu Cys Gln His Leu 
        675                 680                 685             


Gly Leu Val Lys Pro Gly Thr Tyr Pro Glu Val Pro Pro Glu Lys Leu 
    690                 695                 700                 


His Arg Cys Phe Arg Leu Gln Val Glu Ser Leu Lys Lys Leu Gly Lys 
705                 710                 715                 720 


Gln Ala Gln Gly Cys Lys Met Val Ile Leu Trp Leu Ala Ala Leu Gln 
                725                 730                 735     


Pro Cys Ser Pro Glu His Met Ala Glu Pro Val Thr Phe Trp Val Arg 
            740                 745                 750         


Val Lys Met Asp Ala Ala Arg Ala Gly Asp Lys Glu Leu Gln Leu Lys 
        755                 760                 765             


Thr Leu Arg Asp Ser Leu Ser Gly Trp Asp Pro Glu Thr Leu Ala Leu 
    770                 775                 780                 


Leu Leu Arg Glu Glu Leu Gln Ala Tyr Lys Ala Val Arg Ala Asp Thr 
785                 790                 795                 800 


Gly Gln Glu Arg Phe Asn Ile Ile Cys Asp Leu Leu Glu Leu Ser Pro 
                805                 810                 815     


Glu Glu Thr Pro Ala Gly Ala Trp Ala Arg Ala Thr His Leu Val Glu 
            820                 825                 830         


Leu Ala Gln Val Leu Cys Tyr His Asp Phe Thr Gln Gln Thr Asn Cys 
        835                 840                 845             


Ser Ala Leu Asp Ala Ile Arg Glu Ala Leu Gln Leu Leu Asp Ser Val 
    850                 855                 860                 


Arg Pro Glu Ala Gln Ala Arg Asp Gln Leu Leu Asp Asp Lys Ala Gln 
865                 870                 875                 880 


Ala Leu Leu Trp Leu Tyr Ile Cys Thr Leu Glu Ala Lys Ile Gln Glu 
                885                 890                 895     


Gly Ile Glu Arg Asp Arg Arg Ala Gln Ala Pro Gly Asn Leu Glu Glu 
            900                 905                 910         


Phe Glu Val Asn Asp Leu Asn Tyr Glu Asp Lys Leu Gln Glu Asp Arg 
        915                 920                 925             


Phe Leu Tyr Ser Asn Ile Ala Phe Asn Leu Ala Ala Asp Ala Ala Gln 
    930                 935                 940                 


Ser Lys Cys Leu Asp Gln Ala Leu Ala Leu Trp Lys Glu Leu Leu Thr 
945                 950                 955                 960 


Lys Gly Gln Ala Pro Ala Val Arg Cys Leu Gln Gln Thr Ala Ala Ser 
                965                 970                 975     


Leu Gln Ile Leu Ala Ala Leu Tyr Gln Leu Val Ala Lys Pro Met Gln 
            980                 985                 990         


Ala Leu Glu Val Leu Leu Leu Leu  Arg Ile Val Ser Glu  Arg Leu Lys 
        995                 1000                 1005             


Asp His  Ser Lys Ala Ala Gly  Ser Ser Cys His Ile  Thr Gln Leu 
    1010                 1015                 1020             


Leu Leu  Thr Leu Gly Cys Pro  Ser Tyr Ala Gln Leu  His Leu Glu 
    1025                 1030                 1035             


Glu Ala  Ala Ser Ser Leu Lys  His Leu Asp Gln Thr  Thr Asp Thr 
    1040                 1045                 1050             


Tyr Leu  Leu Leu Ser Leu Thr  Cys Asp Leu Leu Arg  Ser Gln Leu 
    1055                 1060                 1065             


Tyr Trp  Thr His Gln Lys Val  Thr Lys Gly Val Ser  Leu Leu Leu 
    1070                 1075                 1080             


Ser Val  Leu Arg Asp Pro Ala  Leu Gln Lys Ser Ser  Lys Ala Trp 
    1085                 1090                 1095             


Tyr Leu  Leu Arg Val Gln Val  Leu Gln Leu Val Ala  Ala Tyr Leu 
    1100                 1105                 1110             


Ser Leu  Pro Ser Asn Asn Leu  Ser His Ser Leu Trp  Glu Gln Leu 
    1115                 1120                 1125             


Cys Ala  Gln Gly Trp Gln Thr  Pro Glu Ile Ala Leu  Ile Asp Ser 
    1130                 1135                 1140             


His Lys  Leu Leu Arg Ser Ile  Ile Leu Leu Leu Met  Gly Ser Asp 
    1145                 1150                 1155             


Ile Leu  Ser Thr Gln Lys Ala  Ala Val Glu Thr Ser  Phe Leu Asp 
    1160                 1165                 1170             


Tyr Gly  Glu Asn Leu Val Gln  Lys Trp Gln Val Leu  Ser Glu Val 
    1175                 1180                 1185             


Leu Ser  Cys Ser Glu Lys Leu  Val Cys His Leu Gly  Arg Leu Gly 
    1190                 1195                 1200             


Ser Val  Ser Glu Ala Lys Ala  Phe Cys Leu Glu Ala  Leu Lys Leu 
    1205                 1210                 1215             


Thr Thr  Lys Leu Gln Ile Pro  Arg Gln Cys Ala Leu  Phe Leu Val 
    1220                 1225                 1230             


Leu Lys  Gly Glu Leu Glu Leu  Ala Arg Asn Asp Ile  Asp Leu Cys 
    1235                 1240                 1245             


Gln Ser  Asp Leu Gln Gln Val  Leu Phe Leu Leu Glu  Ser Cys Thr 
    1250                 1255                 1260             


Glu Phe  Gly Gly Val Thr Gln  His Leu Asp Ser Val  Lys Lys Val 
    1265                 1270                 1275             


His Leu  Gln Lys Gly Lys Gln  Gln Ala Gln Val Pro  Cys Pro Pro 
    1280                 1285                 1290             


Gln Leu  Pro Glu Glu Glu Leu  Phe Leu Arg Gly Pro  Ala Leu Glu 
    1295                 1300                 1305             


Leu Val  Ala Thr Val Ala Lys  Glu Pro Gly Pro Ile  Ala Pro Ser 
    1310                 1315                 1320             


Thr Asn  Ser Ala Pro Val Leu  Lys Thr Lys Pro Gln  Pro Ile Pro 
    1325                 1330                 1335             


Asn Phe  Leu Ser His Ser Pro  Thr Cys Asp Cys Ser  Leu Cys Ala 
    1340                 1345                 1350             


Ser Pro  Val Leu Thr Ala Val  Cys Leu Arg Trp Val  Leu Val Thr 
    1355                 1360                 1365             


Ala Gly  Val Arg Leu Ala Met  Gly His Gln Ala Gln  Gly Leu Asp 
    1370                 1375                 1380             


Leu Leu  Gln Val Val Leu Lys  Gly Cys Pro Glu Ala  Ala Glu Arg 
    1385                 1390                 1395             


Leu Thr  Gln Ala Leu Gln Ala  Ser Leu Asn His Lys  Thr Pro Pro 
    1400                 1405                 1410             


Ser Leu  Val Pro Ser Leu Leu  Asp Glu Ile Leu Ala  Gln Ala Tyr 
    1415                 1420                 1425             


Thr Leu  Leu Ala Leu Glu Gly  Leu Asn Gln Pro Ser  Asn Glu Ser 
    1430                 1435                 1440             


Leu Gln  Lys Val Leu Gln Ser  Gly Leu Lys Phe Val  Ala Ala Arg 
    1445                 1450                 1455             


Ile Pro  His Leu Glu Pro Trp  Arg Ala Ser Leu Leu  Leu Ile Trp 
    1460                 1465                 1470             


Ala Leu  Thr Lys Leu Gly Gly  Leu Ser Cys Cys Thr  Thr Gln Leu 
    1475                 1480                 1485             


Phe Ala  Ser Ser Trp Gly Trp  Gln Pro Pro Leu Ile  Lys Ser Val 
    1490                 1495                 1500             


Pro Gly  Ser Glu Pro Ser Lys  Thr Gln Gly Gln Lys  Arg Ser Gly 
    1505                 1510                 1515             


Arg Gly  Arg Gln Lys Leu Ala  Ser Ala Pro Leu Ser  Leu Asn Asn 
    1520                 1525                 1530             


Thr Ser  Gln Lys Gly Leu Glu  Gly Arg Gly Leu Pro  Cys Thr Pro 
    1535                 1540                 1545             


Lys Pro  Pro Asp Arg Ile Arg  Gln Ala Gly Pro His  Val Pro Phe 
    1550                 1555                 1560             


Thr Val  Phe Glu Glu Val Cys  Pro Thr Glu Ser Lys  Pro Glu Val 
    1565                 1570                 1575             


Pro Gln  Ala Pro Arg Val Gln  Gln Arg Val Gln Thr  Arg Leu Lys 
    1580                 1585                 1590             


Val Asn  Phe Ser Asp Asp Ser  Asp Leu Glu Asp Pro  Val Ser Ala 
    1595                 1600                 1605             


Glu Ala  Trp Leu Ala Glu Glu  Pro Lys Arg Arg Gly  Thr Ala Ser 
    1610                 1615                 1620             


Arg Gly  Arg Gly Arg Ala Arg  Lys Gly Leu Ser Leu  Lys Thr Asp 
    1625                 1630                 1635             


Ala Val  Val Ala Pro Gly Ser  Ala Pro Gly Asn Pro  Gly Leu Asn 
    1640                 1645                 1650             


Gly Arg  Ser Arg Arg Ala Lys  Lys Val Ala Ser Arg  His Cys Glu 
    1655                 1660                 1665             


Glu Arg  Arg Pro Gln Arg Ala  Ser Asp Gln Ala Arg  Pro Gly Pro 
    1670                 1675                 1680             


Arg Ile  Met Glu Thr Ile Pro  Glu Glu Glu Leu Thr  Asp Asn Trp 
    1685                 1690                 1695             


Arg Lys  Met Ser Phe Arg Ile  Leu Glu Gly Ser Asp  Gly Glu Asp 
    1700                 1705                 1710             


Ser Ala  Ser Gly Gly Lys Thr  Pro Ala Pro Gly Pro  Glu Ala Ala 
    1715                 1720                 1725             


Ser Gly  Glu Trp Arg Leu Leu  Glu Leu Asp Ser Ser  Lys Lys Lys 
    1730                 1735                 1740             


Leu Pro  Ser Pro Cys Pro Asp  Lys Glu Ser Asp Lys  Asp Leu Gly 
    1745                 1750                 1755             


Pro Arg  Leu Gln Leu Pro Ser  Ala Pro Val Ala Thr  Gly Leu Ser 
    1760                 1765                 1770             


Thr Leu  Asp Ser Ile Cys Asp  Ser Leu Ser Val Ala  Phe Arg Gly 
    1775                 1780                 1785             


Ile Ser  His Cys Pro Pro Ser  Gly Leu Tyr Ala His  Leu Cys Arg 
    1790                 1795                 1800             


Phe Leu  Ala Leu Cys Leu Gly  His Arg Asp Pro Tyr  Ala Thr Ala 
    1805                 1810                 1815             


Phe Leu  Val Thr Glu Ser Val  Ser Ile Thr Cys Arg  His Gln Leu 
    1820                 1825                 1830             


Leu Thr  His Leu His Arg Gln  Leu Ser Lys Ala Gln  Lys His Arg 
    1835                 1840                 1845             


Gly Ser  Leu Glu Ile Ala Asp  Gln Leu Gln Gly Leu  Ser Leu Gln 
    1850                 1855                 1860             


Glu Met  Pro Gly Asp Val Pro  Leu Ala Arg Ile Gln  Arg Leu Phe 
    1865                 1870                 1875             


Ser Phe  Arg Ala Leu Glu Ser  Gly His Phe Pro Gln  Pro Glu Lys 
    1880                 1885                 1890             


Glu Ser  Phe Gln Glu Arg Leu  Ala Leu Ile Pro Ser  Gly Val Thr 
    1895                 1900                 1905             


Val Cys  Val Leu Ala Leu Ala  Thr Leu Gln Pro Gly  Thr Val Gly 
    1910                 1915                 1920             


Asn Thr  Leu Leu Leu Thr Arg  Leu Glu Lys Asp Ser  Pro Pro Val 
    1925                 1930                 1935             


Ser Val  Gln Ile Pro Thr Gly  Gln Asn Lys Leu His  Leu Arg Ser 
    1940                 1945                 1950             


Val Leu  Asn Glu Phe Asp Ala  Ile Gln Lys Ala Gln  Lys Glu Asn 
    1955                 1960                 1965             


Ser Ser  Cys Thr Asp Lys Arg  Glu Trp Trp Thr Gly  Arg Leu Ala 
    1970                 1975                 1980             


Leu Asp  His Arg Met Glu Val  Leu Ile Ala Ser Leu  Glu Lys Ser 
    1985                 1990                 1995             


Val Leu  Gly Cys Trp Lys Gly  Leu Leu Leu Pro Ser  Ser Glu Glu 
    2000                 2005                 2010             


Pro Gly  Pro Ala Gln Glu Ala  Ser Arg Leu Gln Glu  Leu Leu Gln 
    2015                 2020                 2025             


Asp Cys  Gly Trp Lys Tyr Pro  Asp Arg Thr Leu Leu  Lys Ile Met 
    2030                 2035                 2040             


Leu Ser  Gly Ala Gly Ala Leu  Thr Pro Gln Asp Ile  Gln Ala Leu 
    2045                 2050                 2055             


Ala Tyr  Gly Leu Cys Pro Thr  Gln Pro Glu Arg Ala  Gln Glu Leu 
    2060                 2065                 2070             


Leu Asn  Glu Ala Val Gly Arg  Leu Gln Gly Leu Thr  Val Pro Ser 
    2075                 2080                 2085             


Asn Ser  His Leu Val Leu Val  Leu Asp Lys Asp Leu  Gln Lys Leu 
    2090                 2095                 2100             


Pro Trp  Glu Ser Met Pro Ser  Leu Gln Ala Leu Pro  Val Thr Arg 
    2105                 2110                 2115             


Leu Pro  Ser Phe Arg Phe Leu  Leu Ser Tyr Ser Ile  Ile Lys Glu 
    2120                 2125                 2130             


Tyr Gly  Ala Ser Pro Val Leu  Ser Gln Gly Val Asp  Pro Arg Ser 
    2135                 2140                 2145             


Thr Phe  Tyr Val Leu Asn Pro  His Asn Asn Leu Ser  Ser Thr Glu 
    2150                 2155                 2160             


Glu Gln  Phe Arg Ala Asn Phe  Ser Ser Glu Ala Gly  Trp Arg Gly 
    2165                 2170                 2175             


Val Val  Gly Glu Val Pro Arg  Pro Glu Gln Val Gln  Glu Ala Leu 
    2180                 2185                 2190             


Thr Lys  His Asp Leu Tyr Ile  Tyr Ala Gly His Gly  Ala Gly Ala 
    2195                 2200                 2205             


Arg Phe  Leu Asp Gly Gln Ala  Val Leu Arg Leu Ser  Cys Arg Ala 
    2210                 2215                 2220             


Val Ala  Leu Leu Phe Gly Cys  Ser Ser Ala Ala Leu  Ala Val His 
    2225                 2230                 2235             


Gly Asn  Leu Glu Gly Ala Gly  Ile Val Leu Lys Tyr  Ile Met Ala 
    2240                 2245                 2250             


Gly Cys  Pro Leu Phe Leu Gly  Asn Leu Trp Asp Val  Thr Asp Arg 
    2255                 2260                 2265             


Asp Ile  Asp Arg Tyr Thr Glu  Ala Leu Leu Gln Gly  Trp Leu Gly 
    2270                 2275                 2280             


Ala Gly  Pro Gly Ala Pro Leu  Leu Tyr Tyr Val Asn  Gln Ala Arg 
    2285                 2290                 2295             


Gln Ala  Pro Arg Leu Lys Tyr  Leu Ile Gly Ala Ala  Pro Ile Ala 
    2300                 2305                 2310             


Tyr Gly  Leu Pro Val Ser Leu  Arg 
    2315                 2320     


<210> 4
<211> 2284
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met His Trp Ser His Pro Gln Phe Glu Lys Gly Ser Ala Gly Ser Ala 
1               5                   10                  15      


Ala Gly Ser Gly Ala Gly Trp Ser His Pro Gln Phe Glu Lys Gly Ser 
            20                  25                  30          


Ser Thr Ala Ser Glu Asn Leu Tyr Phe Gln Gly Ser Phe Asp Leu Pro 
        35                  40                  45              


Glu Glu His Gln Ile Ala His Leu Pro Leu Ser Gly Val Pro Leu Met 
    50                  55                  60                  


Ile Leu Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln Leu Gly Pro 
65                  70                  75                  80  


Pro Ser Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser Asn Leu Leu 
                85                  90                  95      


Gln Ser Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu Leu Pro Pro 
            100                 105                 110         


Val Cys Cys Asp Ile Asp Ile Gly Gly Ser Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Asp Tyr Lys Asp His 
    130                 135                 140                 


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
145                 150                 155                 160 


Lys Ser Gly Pro Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu 
                165                 170                 175     


Leu Ser Ser Gln Lys Glu Ala Glu Glu Leu Leu Pro Asp Leu Lys Glu 
            180                 185                 190         


Phe Leu Ser Asn Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala 
        195                 200                 205             


Glu Arg Arg Gln Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln 
    210                 215                 220                 


Leu Thr Ala Lys Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu 
225                 230                 235                 240 


Leu Ala Glu Leu Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg 
                245                 250                 255     


Pro Pro Leu Tyr Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala 
            260                 265                 270         


Ala Ala Gln Gly Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu 
        275                 280                 285             


His Ala Cys Leu Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr 
    290                 295                 300                 


Glu Ala Val Ala Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu 
305                 310                 315                 320 


Ala Leu Leu Glu Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu 
                325                 330                 335     


Ser Phe Leu Val Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro 
            340                 345                 350         


His Phe Ala Ser Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu 
        355                 360                 365             


Phe Asp Ala Ser Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu 
    370                 375                 380                 


Asp Asp Leu Leu Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg 
385                 390                 395                 400 


Gly Ser Ser Ser Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu 
                405                 410                 415     


Glu Leu Thr Leu Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His 
            420                 425                 430         


Asp Lys Ala Ile Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn 
        435                 440                 445             


Thr Asn Leu Ala Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu 
    450                 455                 460                 


Leu Gln Val Gly Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile 
465                 470                 475                 480 


Lys Ala Ser Ala Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro 
                485                 490                 495     


Leu Arg Ala Leu Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu 
            500                 505                 510         


Arg Gly Thr Lys Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe 
        515                 520                 525             


Ala Phe Leu Gly Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp 
    530                 535                 540                 


Gly Val Tyr Gly Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met 
545                 550                 555                 560 


Tyr Phe Gln Gly Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala 
                565                 570                 575     


Gln Gly Cys Gln Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp 
            580                 585                 590         


Ser Cys Lys Ser Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu 
        595                 600                 605             


Ser Gly Gln Glu Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr 
    610                 615                 620                 


Ser Asn Leu Ala Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala 
625                 630                 635                 640 


Cys Ala Ile Ser Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro 
                645                 650                 655     


Gly Thr Tyr Pro Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg 
            660                 665                 670         


Leu Gln Val Glu Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys 
        675                 680                 685             


Lys Met Val Ile Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu 
    690                 695                 700                 


His Met Ala Glu Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala 
705                 710                 715                 720 


Ala Arg Ala Gly Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser 
                725                 730                 735     


Leu Ser Gly Trp Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu 
            740                 745                 750         


Leu Gln Ala Tyr Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe 
        755                 760                 765             


Asn Ile Ile Cys Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala 
    770                 775                 780                 


Gly Ala Trp Ala Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu 
785                 790                 795                 800 


Cys Tyr His Asp Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala 
                805                 810                 815     


Ile Arg Glu Ala Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln 
            820                 825                 830         


Ala Arg Asp Gln Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu 
        835                 840                 845             


Tyr Ile Cys Thr Leu Glu Ala Lys Ile Gln Glu Gly Ile Glu Arg Asp 
    850                 855                 860                 


Arg Arg Ala Gln Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp 
865                 870                 875                 880 


Leu Asn Tyr Glu Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn 
                885                 890                 895     


Ile Ala Phe Asn Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp 
            900                 905                 910         


Gln Ala Leu Ala Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro 
        915                 920                 925             


Ala Val Arg Cys Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala 
    930                 935                 940                 


Ala Leu Tyr Gln Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu 
945                 950                 955                 960 


Leu Leu Leu Arg Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala 
                965                 970                 975     


Ala Gly Ser Ser Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys 
            980                 985                 990         


Pro Ser Tyr Ala Gln Leu His Leu  Glu Glu Ala Ala Ser  Ser Leu Lys 
        995                 1000                 1005             


His Leu  Asp Gln Thr Thr Asp  Thr Tyr Leu Leu Leu  Ser Leu Thr 
    1010                 1015                 1020             


Cys Asp  Leu Leu Arg Ser Gln  Leu Tyr Trp Thr His  Gln Lys Val 
    1025                 1030                 1035             


Thr Lys  Gly Val Ser Leu Leu  Leu Ser Val Leu Arg  Asp Pro Ala 
    1040                 1045                 1050             


Leu Gln  Lys Ser Ser Lys Ala  Trp Tyr Leu Leu Arg  Val Gln Val 
    1055                 1060                 1065             


Leu Gln  Leu Val Ala Ala Tyr  Leu Ser Leu Pro Ser  Asn Asn Leu 
    1070                 1075                 1080             


Ser His  Ser Leu Trp Glu Gln  Leu Cys Ala Gln Gly  Trp Gln Thr 
    1085                 1090                 1095             


Pro Glu  Ile Ala Leu Ile Asp  Ser His Lys Leu Leu  Arg Ser Ile 
    1100                 1105                 1110             


Ile Leu  Leu Leu Met Gly Ser  Asp Ile Leu Ser Thr  Gln Lys Ala 
    1115                 1120                 1125             


Ala Val  Glu Thr Ser Phe Leu  Asp Tyr Gly Glu Asn  Leu Val Gln 
    1130                 1135                 1140             


Lys Trp  Gln Val Leu Ser Glu  Val Leu Ser Cys Ser  Glu Lys Leu 
    1145                 1150                 1155             


Val Cys  His Leu Gly Arg Leu  Gly Ser Val Ser Glu  Ala Lys Ala 
    1160                 1165                 1170             


Phe Cys  Leu Glu Ala Leu Lys  Leu Thr Thr Lys Leu  Gln Ile Pro 
    1175                 1180                 1185             


Arg Gln  Cys Ala Leu Phe Leu  Val Leu Lys Gly Glu  Leu Glu Leu 
    1190                 1195                 1200             


Ala Arg  Asn Asp Ile Asp Leu  Cys Gln Ser Asp Leu  Gln Gln Val 
    1205                 1210                 1215             


Leu Phe  Leu Leu Glu Ser Cys  Thr Glu Phe Gly Gly  Val Thr Gln 
    1220                 1225                 1230             


His Leu  Asp Ser Val Lys Lys  Val His Leu Gln Lys  Gly Lys Gln 
    1235                 1240                 1245             


Gln Ala  Gln Val Pro Cys Pro  Pro Gln Leu Pro Glu  Glu Glu Leu 
    1250                 1255                 1260             


Phe Leu  Arg Gly Pro Ala Leu  Glu Leu Val Ala Thr  Val Ala Lys 
    1265                 1270                 1275             


Glu Pro  Gly Pro Ile Ala Pro  Ser Thr Asn Ser Ala  Pro Val Leu 
    1280                 1285                 1290             


Lys Thr  Lys Pro Gln Pro Ile  Pro Asn Phe Leu Ser  His Ser Pro 
    1295                 1300                 1305             


Thr Cys  Asp Cys Ser Leu Cys  Ala Ser Pro Val Leu  Thr Ala Val 
    1310                 1315                 1320             


Cys Leu  Arg Trp Val Leu Val  Thr Ala Gly Val Arg  Leu Ala Met 
    1325                 1330                 1335             


Gly His  Gln Ala Gln Gly Leu  Asp Leu Leu Gln Val  Val Leu Lys 
    1340                 1345                 1350             


Gly Cys  Pro Glu Ala Ala Glu  Arg Leu Thr Gln Ala  Leu Gln Ala 
    1355                 1360                 1365             


Ser Leu  Asn His Lys Thr Pro  Pro Ser Leu Val Pro  Ser Leu Leu 
    1370                 1375                 1380             


Asp Glu  Ile Leu Ala Gln Ala  Tyr Thr Leu Leu Ala  Leu Glu Gly 
    1385                 1390                 1395             


Leu Asn  Gln Pro Ser Asn Glu  Ser Leu Gln Lys Val  Leu Gln Ser 
    1400                 1405                 1410             


Gly Leu  Lys Phe Val Ala Ala  Arg Ile Pro His Leu  Glu Pro Trp 
    1415                 1420                 1425             


Arg Ala  Ser Leu Leu Leu Ile  Trp Ala Leu Thr Lys  Leu Gly Gly 
    1430                 1435                 1440             


Leu Ser  Cys Cys Thr Thr Gln  Leu Phe Ala Ser Ser  Trp Gly Trp 
    1445                 1450                 1455             


Gln Pro  Pro Leu Ile Lys Ser  Val Pro Gly Ser Glu  Pro Ser Lys 
    1460                 1465                 1470             


Thr Gln  Gly Gln Lys Arg Ser  Gly Arg Gly Arg Gln  Lys Leu Ala 
    1475                 1480                 1485             


Ser Ala  Pro Leu Ser Leu Asn  Asn Thr Ser Gln Lys  Gly Leu Glu 
    1490                 1495                 1500             


Gly Arg  Gly Leu Pro Cys Thr  Pro Lys Pro Pro Asp  Arg Ile Arg 
    1505                 1510                 1515             


Gln Ala  Gly Pro His Val Pro  Phe Thr Val Phe Glu  Glu Val Cys 
    1520                 1525                 1530             


Pro Thr  Glu Ser Lys Pro Glu  Val Pro Gln Ala Pro  Arg Val Gln 
    1535                 1540                 1545             


Gln Arg  Val Gln Thr Arg Leu  Lys Val Asn Phe Ser  Asp Asp Ser 
    1550                 1555                 1560             


Asp Leu  Glu Asp Pro Val Ser  Ala Glu Ala Trp Leu  Ala Glu Glu 
    1565                 1570                 1575             


Pro Lys  Arg Arg Gly Thr Ala  Ser Arg Gly Arg Gly  Arg Ala Arg 
    1580                 1585                 1590             


Lys Gly  Leu Ser Leu Lys Thr  Asp Ala Val Val Ala  Pro Gly Ser 
    1595                 1600                 1605             


Ala Pro  Gly Asn Pro Gly Leu  Asn Gly Arg Ser Arg  Arg Ala Lys 
    1610                 1615                 1620             


Lys Val  Ala Ser Arg His Cys  Glu Glu Arg Arg Pro  Gln Arg Ala 
    1625                 1630                 1635             


Ser Asp  Gln Ala Arg Pro Gly  Pro Arg Ile Met Glu  Thr Ile Pro 
    1640                 1645                 1650             


Glu Glu  Glu Leu Thr Asp Asn  Trp Arg Lys Met Ser  Phe Arg Ile 
    1655                 1660                 1665             


Leu Glu  Gly Ser Asp Gly Glu  Asp Ser Ala Ser Gly  Gly Lys Thr 
    1670                 1675                 1680             


Pro Ala  Pro Gly Pro Glu Ala  Ala Ser Gly Glu Trp  Arg Leu Leu 
    1685                 1690                 1695             


Glu Leu  Asp Ser Ser Lys Lys  Lys Leu Pro Ser Pro  Cys Pro Asp 
    1700                 1705                 1710             


Lys Glu  Ser Asp Lys Asp Leu  Gly Pro Arg Leu Gln  Leu Pro Ser 
    1715                 1720                 1725             


Ala Pro  Val Ala Thr Gly Leu  Ser Thr Leu Asp Ser  Ile Cys Asp 
    1730                 1735                 1740             


Ser Leu  Ser Val Ala Phe Arg  Gly Ile Ser His Cys  Pro Pro Ser 
    1745                 1750                 1755             


Gly Leu  Tyr Ala His Leu Cys  Arg Phe Leu Ala Leu  Cys Leu Gly 
    1760                 1765                 1770             


His Arg  Asp Pro Tyr Ala Thr  Ala Phe Leu Val Thr  Glu Ser Val 
    1775                 1780                 1785             


Ser Ile  Thr Cys Arg His Gln  Leu Leu Thr His Leu  His Arg Gln 
    1790                 1795                 1800             


Leu Ser  Lys Ala Gln Lys His  Arg Gly Ser Leu Glu  Ile Ala Asp 
    1805                 1810                 1815             


Gln Leu  Gln Gly Leu Ser Leu  Gln Glu Met Pro Gly  Asp Val Pro 
    1820                 1825                 1830             


Leu Ala  Arg Ile Gln Arg Leu  Phe Ser Phe Arg Ala  Leu Glu Ser 
    1835                 1840                 1845             


Gly His  Phe Pro Gln Pro Glu  Lys Glu Ser Phe Gln  Glu Arg Leu 
    1850                 1855                 1860             


Ala Leu  Ile Pro Ser Gly Val  Thr Val Cys Val Leu  Ala Leu Ala 
    1865                 1870                 1875             


Thr Leu  Gln Pro Gly Thr Val  Gly Asn Thr Leu Leu  Leu Thr Arg 
    1880                 1885                 1890             


Leu Glu  Lys Asp Ser Pro Pro  Val Ser Val Gln Ile  Pro Thr Gly 
    1895                 1900                 1905             


Gln Asn  Lys Leu His Leu Arg  Ser Val Leu Asn Glu  Phe Asp Ala 
    1910                 1915                 1920             


Ile Gln  Lys Ala Gln Lys Glu  Asn Ser Ser Cys Thr  Asp Lys Arg 
    1925                 1930                 1935             


Glu Trp  Trp Thr Gly Arg Leu  Ala Leu Asp His Arg  Met Glu Val 
    1940                 1945                 1950             


Leu Ile  Ala Ser Leu Glu Lys  Ser Val Leu Gly Cys  Trp Lys Gly 
    1955                 1960                 1965             


Leu Leu  Leu Pro Ser Ser Glu  Glu Pro Gly Pro Ala  Gln Glu Ala 
    1970                 1975                 1980             


Ser Arg  Leu Gln Glu Leu Leu  Gln Asp Cys Gly Trp  Lys Tyr Pro 
    1985                 1990                 1995             


Asp Arg  Thr Leu Leu Lys Ile  Met Leu Ser Gly Ala  Gly Ala Leu 
    2000                 2005                 2010             


Thr Pro  Gln Asp Ile Gln Ala  Leu Ala Tyr Gly Leu  Cys Pro Thr 
    2015                 2020                 2025             


Gln Pro  Glu Arg Ala Gln Glu  Leu Leu Asn Glu Ala  Val Gly Arg 
    2030                 2035                 2040             


Leu Gln  Gly Leu Thr Val Pro  Ser Asn Ser His Leu  Val Leu Val 
    2045                 2050                 2055             


Leu Asp  Lys Asp Leu Gln Lys  Leu Pro Trp Glu Ser  Met Pro Ser 
    2060                 2065                 2070             


Leu Gln  Ala Leu Pro Val Thr  Arg Leu Pro Ser Phe  Arg Phe Leu 
    2075                 2080                 2085             


Leu Ser  Tyr Ser Ile Ile Lys  Glu Tyr Gly Ala Ser  Pro Val Leu 
    2090                 2095                 2100             


Ser Gln  Gly Val Asp Pro Arg  Ser Thr Phe Tyr Val  Leu Asn Pro 
    2105                 2110                 2115             


His Asn  Asn Leu Ser Ser Thr  Glu Glu Gln Phe Arg  Ala Asn Phe 
    2120                 2125                 2130             


Ser Ser  Glu Ala Gly Trp Arg  Gly Val Val Gly Glu  Val Pro Arg 
    2135                 2140                 2145             


Pro Glu  Gln Val Gln Glu Ala  Leu Thr Lys His Asp  Leu Tyr Ile 
    2150                 2155                 2160             


Tyr Ala  Gly His Gly Ala Gly  Ala Arg Phe Leu Asp  Gly Gln Ala 
    2165                 2170                 2175             


Val Leu  Arg Leu Ser Cys Arg  Ala Val Ala Leu Leu  Phe Gly Cys 
    2180                 2185                 2190             


Ser Ser  Ala Ala Leu Ala Val  His Gly Asn Leu Glu  Gly Ala Gly 
    2195                 2200                 2205             


Ile Val  Leu Lys Tyr Ile Met  Ala Gly Cys Pro Leu  Phe Leu Gly 
    2210                 2215                 2220             


Asn Leu  Trp Asp Val Thr Asp  Arg Asp Ile Asp Arg  Tyr Thr Glu 
    2225                 2230                 2235             


Ala Leu  Leu Gln Gly Trp Leu  Gly Ala Gly Pro Gly  Ala Pro Leu 
    2240                 2245                 2250             


Leu Tyr  Tyr Val Asn Gln Ala  Arg Gln Ala Pro Arg  Leu Lys Tyr 
    2255                 2260                 2265             


Leu Ile  Gly Ala Ala Pro Ile  Ala Tyr Gly Leu Pro  Val Ser Leu 
    2270                 2275                 2280             


Arg 
    


<210> 5
<211> 2268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met His Trp Ser His Pro Gln Phe Glu Lys Gly Ser Ala Gly Ser Ala 
1               5                   10                  15      


Ala Gly Ser Gly Ala Gly Trp Ser His Pro Gln Phe Glu Lys Gly Ser 
            20                  25                  30          


Ser Thr Ala Ser His Leu Pro Leu Ser Gly Val Pro Leu Met Ile Leu 
        35                  40                  45              


Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln Leu Gly Pro Pro Ser 
    50                  55                  60                  


Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser Asn Leu Leu Gln Ser 
65                  70                  75                  80  


Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu Leu Pro Pro Val Cys 
                85                  90                  95      


Cys Asp Ile Asp Ile Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Glu Asn Leu Tyr Phe Gln Gly Asp Tyr Lys Asp His 
        115                 120                 125             


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
    130                 135                 140                 


Lys Ser Gly Pro Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu 
145                 150                 155                 160 


Leu Ser Ser Gln Lys Glu Ala Glu Glu Leu Leu Pro Asp Leu Lys Glu 
                165                 170                 175     


Phe Leu Ser Asn Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala 
            180                 185                 190         


Glu Arg Arg Gln Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln 
        195                 200                 205             


Leu Thr Ala Lys Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu 
    210                 215                 220                 


Leu Ala Glu Leu Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg 
225                 230                 235                 240 


Pro Pro Leu Tyr Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala 
                245                 250                 255     


Ala Ala Gln Gly Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu 
            260                 265                 270         


His Ala Cys Leu Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr 
        275                 280                 285             


Glu Ala Val Ala Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu 
    290                 295                 300                 


Ala Leu Leu Glu Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu 
305                 310                 315                 320 


Ser Phe Leu Val Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro 
                325                 330                 335     


His Phe Ala Ser Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu 
            340                 345                 350         


Phe Asp Ala Ser Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu 
        355                 360                 365             


Asp Asp Leu Leu Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg 
    370                 375                 380                 


Gly Ser Ser Ser Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu 
385                 390                 395                 400 


Glu Leu Thr Leu Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His 
                405                 410                 415     


Asp Lys Ala Ile Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn 
            420                 425                 430         


Thr Asn Leu Ala Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu 
        435                 440                 445             


Leu Gln Val Gly Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile 
    450                 455                 460                 


Lys Ala Ser Ala Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro 
465                 470                 475                 480 


Leu Arg Ala Leu Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu 
                485                 490                 495     


Arg Gly Thr Lys Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe 
            500                 505                 510         


Ala Phe Leu Gly Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp 
        515                 520                 525             


Gly Val Tyr Gly Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met 
    530                 535                 540                 


Tyr Phe Gln Gly Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala 
545                 550                 555                 560 


Gln Gly Cys Gln Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp 
                565                 570                 575     


Ser Cys Lys Ser Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu 
            580                 585                 590         


Ser Gly Gln Glu Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr 
        595                 600                 605             


Ser Asn Leu Ala Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala 
    610                 615                 620                 


Cys Ala Ile Ser Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro 
625                 630                 635                 640 


Gly Thr Tyr Pro Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg 
                645                 650                 655     


Leu Gln Val Glu Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys 
            660                 665                 670         


Lys Met Val Ile Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu 
        675                 680                 685             


His Met Ala Glu Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala 
    690                 695                 700                 


Ala Arg Ala Gly Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser 
705                 710                 715                 720 


Leu Ser Gly Trp Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu 
                725                 730                 735     


Leu Gln Ala Tyr Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe 
            740                 745                 750         


Asn Ile Ile Cys Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala 
        755                 760                 765             


Gly Ala Trp Ala Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu 
    770                 775                 780                 


Cys Tyr His Asp Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala 
785                 790                 795                 800 


Ile Arg Glu Ala Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln 
                805                 810                 815     


Ala Arg Asp Gln Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu 
            820                 825                 830         


Tyr Ile Cys Thr Leu Glu Ala Lys Ile Gln Glu Gly Ile Glu Arg Asp 
        835                 840                 845             


Arg Arg Ala Gln Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp 
    850                 855                 860                 


Leu Asn Tyr Glu Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn 
865                 870                 875                 880 


Ile Ala Phe Asn Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp 
                885                 890                 895     


Gln Ala Leu Ala Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro 
            900                 905                 910         


Ala Val Arg Cys Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala 
        915                 920                 925             


Ala Leu Tyr Gln Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu 
    930                 935                 940                 


Leu Leu Leu Arg Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala 
945                 950                 955                 960 


Ala Gly Ser Ser Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys 
                965                 970                 975     


Pro Ser Tyr Ala Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys 
            980                 985                 990         


His Leu Asp Gln Thr Thr Asp Thr  Tyr Leu Leu Leu Ser  Leu Thr Cys 
        995                 1000                 1005             


Asp Leu  Leu Arg Ser Gln Leu  Tyr Trp Thr His Gln  Lys Val Thr 
    1010                 1015                 1020             


Lys Gly  Val Ser Leu Leu Leu  Ser Val Leu Arg Asp  Pro Ala Leu 
    1025                 1030                 1035             


Gln Lys  Ser Ser Lys Ala Trp  Tyr Leu Leu Arg Val  Gln Val Leu 
    1040                 1045                 1050             


Gln Leu  Val Ala Ala Tyr Leu  Ser Leu Pro Ser Asn  Asn Leu Ser 
    1055                 1060                 1065             


His Ser  Leu Trp Glu Gln Leu  Cys Ala Gln Gly Trp  Gln Thr Pro 
    1070                 1075                 1080             


Glu Ile  Ala Leu Ile Asp Ser  His Lys Leu Leu Arg  Ser Ile Ile 
    1085                 1090                 1095             


Leu Leu  Leu Met Gly Ser Asp  Ile Leu Ser Thr Gln  Lys Ala Ala 
    1100                 1105                 1110             


Val Glu  Thr Ser Phe Leu Asp  Tyr Gly Glu Asn Leu  Val Gln Lys 
    1115                 1120                 1125             


Trp Gln  Val Leu Ser Glu Val  Leu Ser Cys Ser Glu  Lys Leu Val 
    1130                 1135                 1140             


Cys His  Leu Gly Arg Leu Gly  Ser Val Ser Glu Ala  Lys Ala Phe 
    1145                 1150                 1155             


Cys Leu  Glu Ala Leu Lys Leu  Thr Thr Lys Leu Gln  Ile Pro Arg 
    1160                 1165                 1170             


Gln Cys  Ala Leu Phe Leu Val  Leu Lys Gly Glu Leu  Glu Leu Ala 
    1175                 1180                 1185             


Arg Asn  Asp Ile Asp Leu Cys  Gln Ser Asp Leu Gln  Gln Val Leu 
    1190                 1195                 1200             


Phe Leu  Leu Glu Ser Cys Thr  Glu Phe Gly Gly Val  Thr Gln His 
    1205                 1210                 1215             


Leu Asp  Ser Val Lys Lys Val  His Leu Gln Lys Gly  Lys Gln Gln 
    1220                 1225                 1230             


Ala Gln  Val Pro Cys Pro Pro  Gln Leu Pro Glu Glu  Glu Leu Phe 
    1235                 1240                 1245             


Leu Arg  Gly Pro Ala Leu Glu  Leu Val Ala Thr Val  Ala Lys Glu 
    1250                 1255                 1260             


Pro Gly  Pro Ile Ala Pro Ser  Thr Asn Ser Ala Pro  Val Leu Lys 
    1265                 1270                 1275             


Thr Lys  Pro Gln Pro Ile Pro  Asn Phe Leu Ser His  Ser Pro Thr 
    1280                 1285                 1290             


Cys Asp  Cys Ser Leu Cys Ala  Ser Pro Val Leu Thr  Ala Val Cys 
    1295                 1300                 1305             


Leu Arg  Trp Val Leu Val Thr  Ala Gly Val Arg Leu  Ala Met Gly 
    1310                 1315                 1320             


His Gln  Ala Gln Gly Leu Asp  Leu Leu Gln Val Val  Leu Lys Gly 
    1325                 1330                 1335             


Cys Pro  Glu Ala Ala Glu Arg  Leu Thr Gln Ala Leu  Gln Ala Ser 
    1340                 1345                 1350             


Leu Asn  His Lys Thr Pro Pro  Ser Leu Val Pro Ser  Leu Leu Asp 
    1355                 1360                 1365             


Glu Ile  Leu Ala Gln Ala Tyr  Thr Leu Leu Ala Leu  Glu Gly Leu 
    1370                 1375                 1380             


Asn Gln  Pro Ser Asn Glu Ser  Leu Gln Lys Val Leu  Gln Ser Gly 
    1385                 1390                 1395             


Leu Lys  Phe Val Ala Ala Arg  Ile Pro His Leu Glu  Pro Trp Arg 
    1400                 1405                 1410             


Ala Ser  Leu Leu Leu Ile Trp  Ala Leu Thr Lys Leu  Gly Gly Leu 
    1415                 1420                 1425             


Ser Cys  Cys Thr Thr Gln Leu  Phe Ala Ser Ser Trp  Gly Trp Gln 
    1430                 1435                 1440             


Pro Pro  Leu Ile Lys Ser Val  Pro Gly Ser Glu Pro  Ser Lys Thr 
    1445                 1450                 1455             


Gln Gly  Gln Lys Arg Ser Gly  Arg Gly Arg Gln Lys  Leu Ala Ser 
    1460                 1465                 1470             


Ala Pro  Leu Ser Leu Asn Asn  Thr Ser Gln Lys Gly  Leu Glu Gly 
    1475                 1480                 1485             


Arg Gly  Leu Pro Cys Thr Pro  Lys Pro Pro Asp Arg  Ile Arg Gln 
    1490                 1495                 1500             


Ala Gly  Pro His Val Pro Phe  Thr Val Phe Glu Glu  Val Cys Pro 
    1505                 1510                 1515             


Thr Glu  Ser Lys Pro Glu Val  Pro Gln Ala Pro Arg  Val Gln Gln 
    1520                 1525                 1530             


Arg Val  Gln Thr Arg Leu Lys  Val Asn Phe Ser Asp  Asp Ser Asp 
    1535                 1540                 1545             


Leu Glu  Asp Pro Val Ser Ala  Glu Ala Trp Leu Ala  Glu Glu Pro 
    1550                 1555                 1560             


Lys Arg  Arg Gly Thr Ala Ser  Arg Gly Arg Gly Arg  Ala Arg Lys 
    1565                 1570                 1575             


Gly Leu  Ser Leu Lys Thr Asp  Ala Val Val Ala Pro  Gly Ser Ala 
    1580                 1585                 1590             


Pro Gly  Asn Pro Gly Leu Asn  Gly Arg Ser Arg Arg  Ala Lys Lys 
    1595                 1600                 1605             


Val Ala  Ser Arg His Cys Glu  Glu Arg Arg Pro Gln  Arg Ala Ser 
    1610                 1615                 1620             


Asp Gln  Ala Arg Pro Gly Pro  Arg Ile Met Glu Thr  Ile Pro Glu 
    1625                 1630                 1635             


Glu Glu  Leu Thr Asp Asn Trp  Arg Lys Met Ser Phe  Arg Ile Leu 
    1640                 1645                 1650             


Glu Gly  Ser Asp Gly Glu Asp  Ser Ala Ser Gly Gly  Lys Thr Pro 
    1655                 1660                 1665             


Ala Pro  Gly Pro Glu Ala Ala  Ser Gly Glu Trp Arg  Leu Leu Glu 
    1670                 1675                 1680             


Leu Asp  Ser Ser Lys Lys Lys  Leu Pro Ser Pro Cys  Pro Asp Lys 
    1685                 1690                 1695             


Glu Ser  Asp Lys Asp Leu Gly  Pro Arg Leu Gln Leu  Pro Ser Ala 
    1700                 1705                 1710             


Pro Val  Ala Thr Gly Leu Ser  Thr Leu Asp Ser Ile  Cys Asp Ser 
    1715                 1720                 1725             


Leu Ser  Val Ala Phe Arg Gly  Ile Ser His Cys Pro  Pro Ser Gly 
    1730                 1735                 1740             


Leu Tyr  Ala His Leu Cys Arg  Phe Leu Ala Leu Cys  Leu Gly His 
    1745                 1750                 1755             


Arg Asp  Pro Tyr Ala Thr Ala  Phe Leu Val Thr Glu  Ser Val Ser 
    1760                 1765                 1770             


Ile Thr  Cys Arg His Gln Leu  Leu Thr His Leu His  Arg Gln Leu 
    1775                 1780                 1785             


Ser Lys  Ala Gln Lys His Arg  Gly Ser Leu Glu Ile  Ala Asp Gln 
    1790                 1795                 1800             


Leu Gln  Gly Leu Ser Leu Gln  Glu Met Pro Gly Asp  Val Pro Leu 
    1805                 1810                 1815             


Ala Arg  Ile Gln Arg Leu Phe  Ser Phe Arg Ala Leu  Glu Ser Gly 
    1820                 1825                 1830             


His Phe  Pro Gln Pro Glu Lys  Glu Ser Phe Gln Glu  Arg Leu Ala 
    1835                 1840                 1845             


Leu Ile  Pro Ser Gly Val Thr  Val Cys Val Leu Ala  Leu Ala Thr 
    1850                 1855                 1860             


Leu Gln  Pro Gly Thr Val Gly  Asn Thr Leu Leu Leu  Thr Arg Leu 
    1865                 1870                 1875             


Glu Lys  Asp Ser Pro Pro Val  Ser Val Gln Ile Pro  Thr Gly Gln 
    1880                 1885                 1890             


Asn Lys  Leu His Leu Arg Ser  Val Leu Asn Glu Phe  Asp Ala Ile 
    1895                 1900                 1905             


Gln Lys  Ala Gln Lys Glu Asn  Ser Ser Cys Thr Asp  Lys Arg Glu 
    1910                 1915                 1920             


Trp Trp  Thr Gly Arg Leu Ala  Leu Asp His Arg Met  Glu Val Leu 
    1925                 1930                 1935             


Ile Ala  Ser Leu Glu Lys Ser  Val Leu Gly Cys Trp  Lys Gly Leu 
    1940                 1945                 1950             


Leu Leu  Pro Ser Ser Glu Glu  Pro Gly Pro Ala Gln  Glu Ala Ser 
    1955                 1960                 1965             


Arg Leu  Gln Glu Leu Leu Gln  Asp Cys Gly Trp Lys  Tyr Pro Asp 
    1970                 1975                 1980             


Arg Thr  Leu Leu Lys Ile Met  Leu Ser Gly Ala Gly  Ala Leu Thr 
    1985                 1990                 1995             


Pro Gln  Asp Ile Gln Ala Leu  Ala Tyr Gly Leu Cys  Pro Thr Gln 
    2000                 2005                 2010             


Pro Glu  Arg Ala Gln Glu Leu  Leu Asn Glu Ala Val  Gly Arg Leu 
    2015                 2020                 2025             


Gln Gly  Leu Thr Val Pro Ser  Asn Ser His Leu Val  Leu Val Leu 
    2030                 2035                 2040             


Asp Lys  Asp Leu Gln Lys Leu  Pro Trp Glu Ser Met  Pro Ser Leu 
    2045                 2050                 2055             


Gln Ala  Leu Pro Val Thr Arg  Leu Pro Ser Phe Arg  Phe Leu Leu 
    2060                 2065                 2070             


Ser Tyr  Ser Ile Ile Lys Glu  Tyr Gly Ala Ser Pro  Val Leu Ser 
    2075                 2080                 2085             


Gln Gly  Val Asp Pro Arg Ser  Thr Phe Tyr Val Leu  Asn Pro His 
    2090                 2095                 2100             


Asn Asn  Leu Ser Ser Thr Glu  Glu Gln Phe Arg Ala  Asn Phe Ser 
    2105                 2110                 2115             


Ser Glu  Ala Gly Trp Arg Gly  Val Val Gly Glu Val  Pro Arg Pro 
    2120                 2125                 2130             


Glu Gln  Val Gln Glu Ala Leu  Thr Lys His Asp Leu  Tyr Ile Tyr 
    2135                 2140                 2145             


Ala Gly  His Gly Ala Gly Ala  Arg Phe Leu Asp Gly  Gln Ala Val 
    2150                 2155                 2160             


Leu Arg  Leu Ser Cys Arg Ala  Val Ala Leu Leu Phe  Gly Cys Ser 
    2165                 2170                 2175             


Ser Ala  Ala Leu Ala Val His  Gly Asn Leu Glu Gly  Ala Gly Ile 
    2180                 2185                 2190             


Val Leu  Lys Tyr Ile Met Ala  Gly Cys Pro Leu Phe  Leu Gly Asn 
    2195                 2200                 2205             


Leu Trp  Asp Val Thr Asp Arg  Asp Ile Asp Arg Tyr  Thr Glu Ala 
    2210                 2215                 2220             


Leu Leu  Gln Gly Trp Leu Gly  Ala Gly Pro Gly Ala  Pro Leu Leu 
    2225                 2230                 2235             


Tyr Tyr  Val Asn Gln Ala Arg  Gln Ala Pro Arg Leu  Lys Tyr Leu 
    2240                 2245                 2250             


Ile Gly  Ala Ala Pro Ile Ala  Tyr Gly Leu Pro Val  Ser Leu Arg 
    2255                 2260                 2265             


<210> 6
<211> 2246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met His Trp Ser His Pro Gln Phe Glu Lys Gly Ser Ala Gly Ser Ala 
1               5                   10                  15      


Ala Gly Ser Gly Ala Gly Trp Ser His Pro Gln Phe Glu Lys Gly Ser 
            20                  25                  30          


Ser Thr Ala Ser Gln Leu Gly Pro Pro Ser Pro Val Lys Met Pro Ser 
        35                  40                  45              


Pro Pro Trp Glu Ser Asn Leu Leu Gln Ser Pro Ser Ser Ile Leu Ser 
    50                  55                  60                  


Thr Leu Asp Val Glu Leu Pro Pro Val Cys Cys Asp Ile Asp Ile Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Asn 
                85                  90                  95      


Leu Tyr Phe Gln Gly Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            100                 105                 110         


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Ser Gly Pro Met Arg 
        115                 120                 125             


Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln Lys Glu 
    130                 135                 140                 


Ala Glu Glu Leu Leu Pro Asp Leu Lys Glu Phe Leu Ser Asn Pro Pro 
145                 150                 155                 160 


Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln Ala Cys 
                165                 170                 175     


Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys Leu Ala 
            180                 185                 190         


Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu Ala Cys 
        195                 200                 205             


Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr Leu Glu 
    210                 215                 220                 


Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly Ser Pro 
225                 230                 235                 240 


Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu Val Gln 
                245                 250                 255     


Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala Arg Gly 
            260                 265                 270         


Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu Arg Arg 
        275                 280                 285             


Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val Leu Leu 
    290                 295                 300                 


Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser Pro Thr 
305                 310                 315                 320 


Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser Gly His 
                325                 330                 335     


Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu Ser Arg 
            340                 345                 350         


His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser Gly Leu 
        355                 360                 365             


Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu Glu His 
    370                 375                 380                 


Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile Ser Ala 
385                 390                 395                 400 


Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala Pro Ser 
                405                 410                 415     


Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly Glu Glu 
            420                 425                 430         


Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala Val Leu 
        435                 440                 445             


Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu Tyr Glu 
    450                 455                 460                 


Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys Arg Arg 
465                 470                 475                 480 


Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly Gly Tyr 
                485                 490                 495     


Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly Gly Ser 
            500                 505                 510         


Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly Leu His 
        515                 520                 525             


Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln Ile Val 
    530                 535                 540                 


Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser Thr Val 
545                 550                 555                 560 


Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu Leu Thr 
                565                 570                 575     


Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala Tyr Ser 
            580                 585                 590         


Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser Glu Pro 
        595                 600                 605             


Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro Glu Val 
    610                 615                 620                 


Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu Ser Leu 
625                 630                 635                 640 


Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile Leu Trp 
                645                 650                 655     


Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu Pro Val 
            660                 665                 670         


Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly Asp Lys 
        675                 680                 685             


Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp Asp Pro 
    690                 695                 700                 


Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr Lys Ala 
705                 710                 715                 720 


Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys Asp Leu 
                725                 730                 735     


Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala Arg Ala 
            740                 745                 750         


Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp Phe Thr 
        755                 760                 765             


Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala Leu Gln 
    770                 775                 780                 


Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln Leu Leu 
785                 790                 795                 800 


Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr Leu Glu 
                805                 810                 815     


Ala Lys Ile Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln Ala Pro 
            820                 825                 830         


Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu Asp Lys 
        835                 840                 845             


Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn Leu Ala 
    850                 855                 860                 


Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala Leu Trp 
865                 870                 875                 880 


Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys Leu Gln 
                885                 890                 895     


Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln Leu Val 
            900                 905                 910         


Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg Ile Val 
        915                 920                 925             


Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser Cys His 
    930                 935                 940                 


Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala Gln Leu 
945                 950                 955                 960 


His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln Thr Thr 
                965                 970                 975     


Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg Ser Gln 
            980                 985                 990         


Leu Tyr Trp Thr His Gln Lys Val  Thr Lys Gly Val Ser  Leu Leu Leu 
        995                 1000                 1005             


Ser Val  Leu Arg Asp Pro Ala  Leu Gln Lys Ser Ser  Lys Ala Trp 
    1010                 1015                 1020             


Tyr Leu  Leu Arg Val Gln Val  Leu Gln Leu Val Ala  Ala Tyr Leu 
    1025                 1030                 1035             


Ser Leu  Pro Ser Asn Asn Leu  Ser His Ser Leu Trp  Glu Gln Leu 
    1040                 1045                 1050             


Cys Ala  Gln Gly Trp Gln Thr  Pro Glu Ile Ala Leu  Ile Asp Ser 
    1055                 1060                 1065             


His Lys  Leu Leu Arg Ser Ile  Ile Leu Leu Leu Met  Gly Ser Asp 
    1070                 1075                 1080             


Ile Leu  Ser Thr Gln Lys Ala  Ala Val Glu Thr Ser  Phe Leu Asp 
    1085                 1090                 1095             


Tyr Gly  Glu Asn Leu Val Gln  Lys Trp Gln Val Leu  Ser Glu Val 
    1100                 1105                 1110             


Leu Ser  Cys Ser Glu Lys Leu  Val Cys His Leu Gly  Arg Leu Gly 
    1115                 1120                 1125             


Ser Val  Ser Glu Ala Lys Ala  Phe Cys Leu Glu Ala  Leu Lys Leu 
    1130                 1135                 1140             


Thr Thr  Lys Leu Gln Ile Pro  Arg Gln Cys Ala Leu  Phe Leu Val 
    1145                 1150                 1155             


Leu Lys  Gly Glu Leu Glu Leu  Ala Arg Asn Asp Ile  Asp Leu Cys 
    1160                 1165                 1170             


Gln Ser  Asp Leu Gln Gln Val  Leu Phe Leu Leu Glu  Ser Cys Thr 
    1175                 1180                 1185             


Glu Phe  Gly Gly Val Thr Gln  His Leu Asp Ser Val  Lys Lys Val 
    1190                 1195                 1200             


His Leu  Gln Lys Gly Lys Gln  Gln Ala Gln Val Pro  Cys Pro Pro 
    1205                 1210                 1215             


Gln Leu  Pro Glu Glu Glu Leu  Phe Leu Arg Gly Pro  Ala Leu Glu 
    1220                 1225                 1230             


Leu Val  Ala Thr Val Ala Lys  Glu Pro Gly Pro Ile  Ala Pro Ser 
    1235                 1240                 1245             


Thr Asn  Ser Ala Pro Val Leu  Lys Thr Lys Pro Gln  Pro Ile Pro 
    1250                 1255                 1260             


Asn Phe  Leu Ser His Ser Pro  Thr Cys Asp Cys Ser  Leu Cys Ala 
    1265                 1270                 1275             


Ser Pro  Val Leu Thr Ala Val  Cys Leu Arg Trp Val  Leu Val Thr 
    1280                 1285                 1290             


Ala Gly  Val Arg Leu Ala Met  Gly His Gln Ala Gln  Gly Leu Asp 
    1295                 1300                 1305             


Leu Leu  Gln Val Val Leu Lys  Gly Cys Pro Glu Ala  Ala Glu Arg 
    1310                 1315                 1320             


Leu Thr  Gln Ala Leu Gln Ala  Ser Leu Asn His Lys  Thr Pro Pro 
    1325                 1330                 1335             


Ser Leu  Val Pro Ser Leu Leu  Asp Glu Ile Leu Ala  Gln Ala Tyr 
    1340                 1345                 1350             


Thr Leu  Leu Ala Leu Glu Gly  Leu Asn Gln Pro Ser  Asn Glu Ser 
    1355                 1360                 1365             


Leu Gln  Lys Val Leu Gln Ser  Gly Leu Lys Phe Val  Ala Ala Arg 
    1370                 1375                 1380             


Ile Pro  His Leu Glu Pro Trp  Arg Ala Ser Leu Leu  Leu Ile Trp 
    1385                 1390                 1395             


Ala Leu  Thr Lys Leu Gly Gly  Leu Ser Cys Cys Thr  Thr Gln Leu 
    1400                 1405                 1410             


Phe Ala  Ser Ser Trp Gly Trp  Gln Pro Pro Leu Ile  Lys Ser Val 
    1415                 1420                 1425             


Pro Gly  Ser Glu Pro Ser Lys  Thr Gln Gly Gln Lys  Arg Ser Gly 
    1430                 1435                 1440             


Arg Gly  Arg Gln Lys Leu Ala  Ser Ala Pro Leu Ser  Leu Asn Asn 
    1445                 1450                 1455             


Thr Ser  Gln Lys Gly Leu Glu  Gly Arg Gly Leu Pro  Cys Thr Pro 
    1460                 1465                 1470             


Lys Pro  Pro Asp Arg Ile Arg  Gln Ala Gly Pro His  Val Pro Phe 
    1475                 1480                 1485             


Thr Val  Phe Glu Glu Val Cys  Pro Thr Glu Ser Lys  Pro Glu Val 
    1490                 1495                 1500             


Pro Gln  Ala Pro Arg Val Gln  Gln Arg Val Gln Thr  Arg Leu Lys 
    1505                 1510                 1515             


Val Asn  Phe Ser Asp Asp Ser  Asp Leu Glu Asp Pro  Val Ser Ala 
    1520                 1525                 1530             


Glu Ala  Trp Leu Ala Glu Glu  Pro Lys Arg Arg Gly  Thr Ala Ser 
    1535                 1540                 1545             


Arg Gly  Arg Gly Arg Ala Arg  Lys Gly Leu Ser Leu  Lys Thr Asp 
    1550                 1555                 1560             


Ala Val  Val Ala Pro Gly Ser  Ala Pro Gly Asn Pro  Gly Leu Asn 
    1565                 1570                 1575             


Gly Arg  Ser Arg Arg Ala Lys  Lys Val Ala Ser Arg  His Cys Glu 
    1580                 1585                 1590             


Glu Arg  Arg Pro Gln Arg Ala  Ser Asp Gln Ala Arg  Pro Gly Pro 
    1595                 1600                 1605             


Arg Ile  Met Glu Thr Ile Pro  Glu Glu Glu Leu Thr  Asp Asn Trp 
    1610                 1615                 1620             


Arg Lys  Met Ser Phe Arg Ile  Leu Glu Gly Ser Asp  Gly Glu Asp 
    1625                 1630                 1635             


Ser Ala  Ser Gly Gly Lys Thr  Pro Ala Pro Gly Pro  Glu Ala Ala 
    1640                 1645                 1650             


Ser Gly  Glu Trp Arg Leu Leu  Glu Leu Asp Ser Ser  Lys Lys Lys 
    1655                 1660                 1665             


Leu Pro  Ser Pro Cys Pro Asp  Lys Glu Ser Asp Lys  Asp Leu Gly 
    1670                 1675                 1680             


Pro Arg  Leu Gln Leu Pro Ser  Ala Pro Val Ala Thr  Gly Leu Ser 
    1685                 1690                 1695             


Thr Leu  Asp Ser Ile Cys Asp  Ser Leu Ser Val Ala  Phe Arg Gly 
    1700                 1705                 1710             


Ile Ser  His Cys Pro Pro Ser  Gly Leu Tyr Ala His  Leu Cys Arg 
    1715                 1720                 1725             


Phe Leu  Ala Leu Cys Leu Gly  His Arg Asp Pro Tyr  Ala Thr Ala 
    1730                 1735                 1740             


Phe Leu  Val Thr Glu Ser Val  Ser Ile Thr Cys Arg  His Gln Leu 
    1745                 1750                 1755             


Leu Thr  His Leu His Arg Gln  Leu Ser Lys Ala Gln  Lys His Arg 
    1760                 1765                 1770             


Gly Ser  Leu Glu Ile Ala Asp  Gln Leu Gln Gly Leu  Ser Leu Gln 
    1775                 1780                 1785             


Glu Met  Pro Gly Asp Val Pro  Leu Ala Arg Ile Gln  Arg Leu Phe 
    1790                 1795                 1800             


Ser Phe  Arg Ala Leu Glu Ser  Gly His Phe Pro Gln  Pro Glu Lys 
    1805                 1810                 1815             


Glu Ser  Phe Gln Glu Arg Leu  Ala Leu Ile Pro Ser  Gly Val Thr 
    1820                 1825                 1830             


Val Cys  Val Leu Ala Leu Ala  Thr Leu Gln Pro Gly  Thr Val Gly 
    1835                 1840                 1845             


Asn Thr  Leu Leu Leu Thr Arg  Leu Glu Lys Asp Ser  Pro Pro Val 
    1850                 1855                 1860             


Ser Val  Gln Ile Pro Thr Gly  Gln Asn Lys Leu His  Leu Arg Ser 
    1865                 1870                 1875             


Val Leu  Asn Glu Phe Asp Ala  Ile Gln Lys Ala Gln  Lys Glu Asn 
    1880                 1885                 1890             


Ser Ser  Cys Thr Asp Lys Arg  Glu Trp Trp Thr Gly  Arg Leu Ala 
    1895                 1900                 1905             


Leu Asp  His Arg Met Glu Val  Leu Ile Ala Ser Leu  Glu Lys Ser 
    1910                 1915                 1920             


Val Leu  Gly Cys Trp Lys Gly  Leu Leu Leu Pro Ser  Ser Glu Glu 
    1925                 1930                 1935             


Pro Gly  Pro Ala Gln Glu Ala  Ser Arg Leu Gln Glu  Leu Leu Gln 
    1940                 1945                 1950             


Asp Cys  Gly Trp Lys Tyr Pro  Asp Arg Thr Leu Leu  Lys Ile Met 
    1955                 1960                 1965             


Leu Ser  Gly Ala Gly Ala Leu  Thr Pro Gln Asp Ile  Gln Ala Leu 
    1970                 1975                 1980             


Ala Tyr  Gly Leu Cys Pro Thr  Gln Pro Glu Arg Ala  Gln Glu Leu 
    1985                 1990                 1995             


Leu Asn  Glu Ala Val Gly Arg  Leu Gln Gly Leu Thr  Val Pro Ser 
    2000                 2005                 2010             


Asn Ser  His Leu Val Leu Val  Leu Asp Lys Asp Leu  Gln Lys Leu 
    2015                 2020                 2025             


Pro Trp  Glu Ser Met Pro Ser  Leu Gln Ala Leu Pro  Val Thr Arg 
    2030                 2035                 2040             


Leu Pro  Ser Phe Arg Phe Leu  Leu Ser Tyr Ser Ile  Ile Lys Glu 
    2045                 2050                 2055             


Tyr Gly  Ala Ser Pro Val Leu  Ser Gln Gly Val Asp  Pro Arg Ser 
    2060                 2065                 2070             


Thr Phe  Tyr Val Leu Asn Pro  His Asn Asn Leu Ser  Ser Thr Glu 
    2075                 2080                 2085             


Glu Gln  Phe Arg Ala Asn Phe  Ser Ser Glu Ala Gly  Trp Arg Gly 
    2090                 2095                 2100             


Val Val  Gly Glu Val Pro Arg  Pro Glu Gln Val Gln  Glu Ala Leu 
    2105                 2110                 2115             


Thr Lys  His Asp Leu Tyr Ile  Tyr Ala Gly His Gly  Ala Gly Ala 
    2120                 2125                 2130             


Arg Phe  Leu Asp Gly Gln Ala  Val Leu Arg Leu Ser  Cys Arg Ala 
    2135                 2140                 2145             


Val Ala  Leu Leu Phe Gly Cys  Ser Ser Ala Ala Leu  Ala Val His 
    2150                 2155                 2160             


Gly Asn  Leu Glu Gly Ala Gly  Ile Val Leu Lys Tyr  Ile Met Ala 
    2165                 2170                 2175             


Gly Cys  Pro Leu Phe Leu Gly  Asn Leu Trp Asp Val  Thr Asp Arg 
    2180                 2185                 2190             


Asp Ile  Asp Arg Tyr Thr Glu  Ala Leu Leu Gln Gly  Trp Leu Gly 
    2195                 2200                 2205             


Ala Gly  Pro Gly Ala Pro Leu  Leu Tyr Tyr Val Asn  Gln Ala Arg 
    2210                 2215                 2220             


Gln Ala  Pro Arg Leu Lys Tyr  Leu Ile Gly Ala Ala  Pro Ile Ala 
    2225                 2230                 2235             


Tyr Gly  Leu Pro Val Ser Leu  Arg 
    2240                 2245     


<210> 7
<211> 2118
<212> PRT
<213> Mus musculus

<400> 7
Met Arg Asn Phe Lys Gly Val Asn Phe Ala Thr Leu Leu Cys Ser Lys 
1               5                   10                  15      


Glu Glu Thr Gln Gln Leu Leu Pro Asp Leu Lys Glu Phe Leu Ser Arg 
            20                  25                  30          


Ser Arg Thr Asp Phe Pro Ser Ser Arg Thr Asp Ala Glu Arg Arg Gln 
        35                  40                  45              


Ile Cys Asp Thr Ile Leu Arg Ala Cys Thr Gln Gln Leu Thr Ala Lys 
    50                  55                  60                  


Leu Asp Cys Pro Gly His Leu Arg Ser Ile Leu Asp Leu Ala Glu Leu 
65                  70                  75                  80  


Ala Cys Asp Gly Tyr Leu Leu Ser Thr Pro Gln Arg Pro Pro Leu Tyr 
                85                  90                  95      


Leu Glu Arg Ile Leu Phe Ile Leu Leu Arg Asn Gly Ser Thr Gln Gly 
            100                 105                 110         


Ser Pro Asp Thr Val Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 
        115                 120                 125             


Val Gln Asn Ser Gly Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Thr 
    130                 135                 140                 


Arg Gly Ser Phe Ser Leu Phe Trp Lys Gly Ala Glu Ala Leu Leu Glu 
145                 150                 155                 160 


Arg Arg Ala Ala Phe Ser Thr Arg Leu Asn Ala Leu Ser Phe Leu Val 
                165                 170                 175     


Leu Leu Glu Asp Gly Ser Val Pro Cys Glu Val Pro His Phe Ala Ser 
            180                 185                 190         


Pro Thr Ala Cys Arg Leu Val Ala Ala Tyr Gln Leu Tyr Asp Ala Thr 
        195                 200                 205             


Gly Gln Gly Leu Asp Glu Ala Asp Ala Asp Phe Leu Tyr Glu Val Leu 
    210                 215                 220                 


Ser Arg His Leu Ile Arg Val Leu Val Gly Glu Gly Gly Ser Ser Pro 
225                 230                 235                 240 


Gly Pro Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Ile Thr Leu 
                245                 250                 255     


Glu His Cys Arg Arg Leu Cys Trp Asn His His His Arg Gln Ala Ala 
            260                 265                 270         


Arg Ala Val Glu Arg Ala Arg Asn His Leu Glu Lys Thr Ser Val Ala 
        275                 280                 285             


Pro Ser Leu Gln Leu Cys Gln Met Gly Val Glu Leu Leu Glu Ala Val 
    290                 295                 300                 


Glu Glu Arg Pro Gly Ala Val Ala Gln Leu Leu Arg Lys Ala Ala Ala 
305                 310                 315                 320 


Val Leu Ile Asn Ser Ile Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 
                325                 330                 335     


Tyr Asp Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Ile Arg 
            340                 345                 350         


Arg His Cys Gly Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 
        355                 360                 365             


Gly Tyr Ser Ser Leu Val Arg His Leu Arg Glu Val Ser Glu Ala Ser 
    370                 375                 380                 


Ser Lys Gln Gln Gln Cys Leu Leu Gln Met His Phe Gln Gly Phe His 
385                 390                 395                 400 


Leu Phe Thr Gly Ile Val Tyr Asp Phe Ala Gln Gly Cys Gln Ala Thr 
                405                 410                 415     


Glu Leu Ala Gln Leu Val Asp Gly Cys Arg Ser Ala Ala Val Trp Met 
            420                 425                 430         


Leu Glu Ala Leu Glu Gly Leu Ser Gly Gly Glu Leu Ala Asp Tyr Leu 
        435                 440                 445             


Ser Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala Tyr Ser Phe Phe Ser 
    450                 455                 460                 


Gln Lys Leu Tyr Glu Glu Ala Cys Val Ile Ser Glu Pro Val Cys Gln 
465                 470                 475                 480 


His Leu Gly Ser Ala Thr Ser Gly Ala Cys Pro Glu Val Pro Pro Glu 
                485                 490                 495     


Lys Leu His Arg Cys Phe Arg Leu His Val Glu Ser Leu Lys Lys Leu 
            500                 505                 510         


Gly Lys Gln Ala Gln Gly Cys Lys Met Val Thr Leu Trp Leu Ala Ala 
        515                 520                 525             


Leu Lys Pro Tyr Ser Leu Glu His Met Val Glu Pro Val Thr Phe Trp 
    530                 535                 540                 


Val Arg Val Lys Met Asp Ala Ser Arg Ala Gly Asp Lys Glu Leu Gln 
545                 550                 555                 560 


Leu Gln Thr Leu Arg Asp Ser Leu Ser Cys Trp Asp Pro Glu Thr Gln 
                565                 570                 575     


Ser Leu Leu Leu Arg Glu Glu Leu Arg Ala Tyr Lys Ser Val Arg Ala 
            580                 585                 590         


Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys Asp Leu Leu Glu Leu 
        595                 600                 605             


Ser Pro Glu Glu Thr Ala Ala Gly Ala Trp Ala Arg Ala Thr Tyr Leu 
    610                 615                 620                 


Val Glu Leu Ala Gln Val Leu Cys Tyr His Asn Phe Thr Gln Gln Thr 
625                 630                 635                 640 


Asn Cys Ser Ala Leu Asp Ala Val Gln Glu Ala Leu Gln Leu Leu Glu 
                645                 650                 655     


Ser Val Ser Pro Glu Ala Gln Glu Gln Asp Arg Leu Leu Asp Asp Lys 
            660                 665                 670         


Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr Leu Glu Ala Lys Met 
        675                 680                 685             


Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln Ala Pro Ser Asn Leu 
    690                 695                 700                 


Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu Asp Lys Leu Gln Glu 
705                 710                 715                 720 


Asp Arg Phe Leu Tyr Ser Ser Ile Ala Phe Asn Leu Ala Ala Asp Ala 
                725                 730                 735     


Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Thr Leu Trp Lys Glu Val 
            740                 745                 750         


Leu Thr Lys Gly Arg Ala Pro Ala Val Arg Cys Leu Gln Gln Thr Ala 
        755                 760                 765             


Ala Ser Leu Gln Ile Leu Ala Ala Val Tyr Gln Leu Val Ala Lys Pro 
    770                 775                 780                 


Leu Gln Ala Leu Glu Thr Leu Leu Leu Leu Gln Ile Val Ser Lys Arg 
785                 790                 795                 800 


Leu Gln Asp His Ala Lys Ala Ala Ser Ser Ser Cys Gln Leu Thr Gln 
                805                 810                 815     


Leu Leu Leu Asn Leu Gly Cys Pro Ser Tyr Ala Gln Leu Tyr Leu Glu 
            820                 825                 830         


Glu Ala Glu Ser Ser Leu Arg Ser Leu Asp Gln Thr Ser Asp Ala Cys 
        835                 840                 845             


Gln Leu Leu Ser Leu Thr Cys Ala Leu Leu Gly Ser Gln Leu Cys Trp 
    850                 855                 860                 


Ala Cys Gln Lys Val Thr Ala Gly Val Ser Leu Leu Leu Ser Val Leu 
865                 870                 875                 880 


Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala Trp Tyr Leu Leu Arg 
                885                 890                 895     


Val Gln Ala Leu Gln Val Leu Ala Phe Tyr Leu Ser Leu Ser Ser Asn 
            900                 905                 910         


Leu Leu Ser Ser Ala Leu Arg Glu Gln Leu Trp Asp Gln Gly Trp Gln 
        915                 920                 925             


Thr Pro Glu Thr Ala Leu Ile Asp Ala His Lys Leu Leu Arg Ser Ile 
    930                 935                 940                 


Ile Ile Leu Leu Met Gly Ser Asp Val Leu Ser Ile Gln Lys Ala Ala 
945                 950                 955                 960 


Thr Glu Ser Pro Phe Leu Asp Tyr Gly Glu Asn Leu Val Gln Lys Trp 
                965                 970                 975     


Gln Val Leu Thr Glu Val Leu Thr Cys Ser Glu Arg Leu Val Gly Arg 
            980                 985                 990         


Leu Gly Arg Leu Gly Asn Val Ser  Glu Ala Lys Ala Phe  Cys Leu Glu 
        995                 1000                 1005             


Ala Leu  Lys Leu Thr Thr Lys  Leu Gln Ile Pro Arg  Gln Cys Ala 
    1010                 1015                 1020             


Leu Phe  Leu Val Leu Lys Gly  Glu Leu Glu Leu Ala  Arg Gly Asp 
    1025                 1030                 1035             


Ile Asp  Leu Cys Gln Ser Asp  Leu Gln Gln Val Leu  Phe Leu Leu 
    1040                 1045                 1050             


Glu Ser  Ser Thr Glu Phe Gly  Val Val Thr Gln His  Pro Asp Ser 
    1055                 1060                 1065             


Val Lys  Lys Val His Thr Gln  Lys Gly Lys His Lys  Ala Gln Gly 
    1070                 1075                 1080             


Pro Cys  Phe Pro Pro Leu Ser  Glu Glu Glu Pro Phe  Leu Lys Gly 
    1085                 1090                 1095             


Pro Ala  Leu Glu Leu Val Asp  Thr Val Leu Asn Glu  Pro Gly Pro 
    1100                 1105                 1110             


Ile Gln  Ser Ser Val Asn Ser  Ser Pro Val Leu Lys  Thr Lys Pro 
    1115                 1120                 1125             


Pro Pro  Asn Pro Gly Phe Leu  Ser His Leu Pro Ser  Cys Asp Cys 
    1130                 1135                 1140             


Leu Leu  Cys Ala Ser Pro Ala  Leu Ser Ala Val Cys  Leu Arg Trp 
    1145                 1150                 1155             


Val Leu  Val Thr Ala Gly Val  Arg Leu Ala Thr Gly  His Lys Ala 
    1160                 1165                 1170             


Gln Gly  Leu Asp Leu Leu Gln  Ala Val Leu Thr Arg  Cys Pro Ala 
    1175                 1180                 1185             


Ala Thr  Lys Arg Phe Thr Gln  Ser Leu Gln Ala Ser  Leu Asn His 
    1190                 1195                 1200             


Arg Thr  Thr Pro Ser Cys Val  Pro Ser Leu Phe Asp  Glu Ile Met 
    1205                 1210                 1215             


Ala Gln  Val Tyr Thr His Leu  Ala Leu Glu Phe Leu  Asn Gln Thr 
    1220                 1225                 1230             


Ser Glu  Lys Ser Leu Gly Lys  Val Leu Ala Ser Gly  Leu Lys Phe 
    1235                 1240                 1245             


Val Ala  Thr Arg Ile Gln Ser  Leu Glu Ile Trp Arg  Ala His Leu 
    1250                 1255                 1260             


Leu Leu  Val Gln Ala Leu Ala  Lys Leu Ala His Phe  Ser Cys Cys 
    1265                 1270                 1275             


Thr Ser  Glu Leu Phe Ala Ser  Ser Trp Gly Trp His  Pro Pro Leu 
    1280                 1285                 1290             


Val Lys  Ser Leu Pro Val Leu  Glu Pro Ala Lys Ile  Arg Arg Gln 
    1295                 1300                 1305             


Lys Cys  Ser Gly Arg Gly Arg  Arg Arg Ile Ala Ser  Val Pro Pro 
    1310                 1315                 1320             


Pro Leu  His Asn Ser Ser Gln  Lys Gly Leu Glu Glu  Glu Gly Pro 
    1325                 1330                 1335             


Pro Cys  Thr Pro Lys Pro Pro  Gly Arg Ala Arg Gln  Ala Gly Pro 
    1340                 1345                 1350             


Arg Val  Pro Phe Thr Ile Phe  Glu Glu Val His Pro  Thr Lys Ser 
    1355                 1360                 1365             


Lys Leu  Gln Val Pro Leu Ala  Pro Arg Val His Arg  Arg Ala Gln 
    1370                 1375                 1380             


Thr Arg  Leu Lys Val Ile Phe  Ser Asp Asp Ser Asp  Leu Glu Asp 
    1385                 1390                 1395             


Leu Val  Ser Ala Asp Thr Gln  Leu Val Glu Glu Pro  Lys Arg Arg 
    1400                 1405                 1410             


Gly Thr  Ala Ser Arg Thr Arg  Gly Gln Thr Arg Lys  Gly Arg Ser 
    1415                 1420                 1425             


Leu Lys  Thr Asp Ala Val Val  Ala Ile Glu Ser Thr  Pro Gly His 
    1430                 1435                 1440             


Ser Ser  Val Ser Gly Arg Thr  Arg Arg Ala Arg Lys  Val Ala Ser 
    1445                 1450                 1455             


Arg Asn  Cys Glu Glu Glu Ser  Pro Lys Ala Pro Leu  Cys Val Trp 
    1460                 1465                 1470             


Ala Ser  Gln Gly Pro Glu Ile  Met Arg Ser Ile Pro  Glu Glu Glu 
    1475                 1480                 1485             


Pro Val  Asp Asn His Leu Glu  Lys Ser Phe Glu Ile  Leu Arg Gly 
    1490                 1495                 1500             


Ser Asp  Gly Glu Asp Ser Ala  Ser Gly Glu Lys Ala  Ala Ala Ala 
    1505                 1510                 1515             


Asp Thr  Gly Leu Pro Val Gly  Glu Cys Glu Val Leu  Arg Arg Asp 
    1520                 1525                 1530             


Ser Ser  Lys Ala Glu Arg Pro  Val Leu Tyr Ser Asp  Thr Glu Ala 
    1535                 1540                 1545             


Asn Ser  Asp Pro Ser Pro Trp  Leu Pro Pro Phe Ser  Val Pro Ala 
    1550                 1555                 1560             


Pro Ile  Asp Leu Ser Thr Leu  Asp Ser Ile Ser Asp  Ser Leu Ser 
    1565                 1570                 1575             


Ile Ala  Phe Arg Gly Val Ser  His Cys Pro Pro Ser  Gly Leu Tyr 
    1580                 1585                 1590             


Ala His  Leu Cys Arg Phe Leu  Ala Leu Cys Leu Gly  His Arg Asp 
    1595                 1600                 1605             


Pro Tyr  Ala Thr Ala Phe Leu  Val Ala Glu Ser Ile  Ser Ile Thr 
    1610                 1615                 1620             


Cys Arg  His Gln Leu Leu Thr  His Leu His Arg Gln  Leu Ser Lys 
    1625                 1630                 1635             


Ala Gln  Lys Gln Gln Glu Ser  Pro Glu Leu Ala Glu  His Leu Gln 
    1640                 1645                 1650             


Arg Leu  Asp Leu Lys Glu Arg  Pro Gly Gly Val Pro  Leu Ala Arg 
    1655                 1660                 1665             


Ile Gln  Arg Leu Phe Ser Phe  Lys Ala Leu Gly Ser  Gly Cys Phe 
    1670                 1675                 1680             


Pro Gln  Ala Glu Lys Glu Ser  Phe Gln Glu Arg Leu  Ala Leu Ile 
    1685                 1690                 1695             


Pro Ser  Gly Val Thr Val Cys  Val Leu Ala Leu Ala  Thr Leu Gln 
    1700                 1705                 1710             


Pro Gly  Thr Leu Ser Asn Thr  Leu Leu Leu Thr Arg  Leu Glu Lys 
    1715                 1720                 1725             


Asp Asn  Pro Pro Ile Thr Val  Lys Ile Pro Thr Ala  Gln Asn Lys 
    1730                 1735                 1740             


Leu Pro  Leu Ser Ala Val Leu  Lys Glu Phe Asp Ala  Ile Gln Lys 
    1745                 1750                 1755             


Asp Gln  Lys Glu Asn Ser Ser  Cys Thr Glu Lys Arg  Val Trp Trp 
    1760                 1765                 1770             


Thr Gly  Arg Leu Ala Leu Asp  Gln Arg Met Glu Ala  Leu Ile Thr 
    1775                 1780                 1785             


Ala Leu  Glu Glu Gln Val Leu  Gly Cys Trp Arg Gly  Leu Leu Leu 
    1790                 1795                 1800             


Pro Cys  Ser Ala Asp Pro Ser  Leu Ala Gln Glu Ala  Ser Lys Leu 
    1805                 1810                 1815             


Gln Glu  Leu Leu Arg Glu Cys  Gly Trp Glu Tyr Pro  Asp Ser Thr 
    1820                 1825                 1830             


Leu Leu  Lys Val Ile Leu Ser  Gly Ala Arg Ile Leu  Thr Ser Gln 
    1835                 1840                 1845             


Asp Val  Gln Ala Leu Ala Cys  Gly Leu Cys Pro Ala  Gln Pro Asp 
    1850                 1855                 1860             


Arg Ala  Gln Val Leu Leu Ser  Glu Ala Val Gly Gln  Val Gln Ser 
    1865                 1870                 1875             


Gln Glu  Ala Pro Arg Ser Gln  His Leu Val Leu Val  Leu Asp Lys 
    1880                 1885                 1890             


Asp Leu  Gln Lys Leu Pro Trp  Glu Ser Thr Pro Ile  Leu Gln Ala 
    1895                 1900                 1905             


Gln Pro  Val Thr Arg Leu Pro  Ser Phe Arg Phe Leu  Leu Ser Tyr 
    1910                 1915                 1920             


Thr Val  Thr Lys Glu Ala Gly  Ala Ser Ser Val Leu  Ser Gln Gly 
    1925                 1930                 1935             


Val Asp  Pro Gln Asn Thr Phe  Tyr Val Leu Asn Pro  His Ser Asn 
    1940                 1945                 1950             


Leu Ser  Ser Thr Glu Glu Arg  Phe Arg Ala Ser Phe  Ser Ser Glu 
    1955                 1960                 1965             


Thr Gly  Trp Lys Gly Val Ile  Gly Glu Val Pro Ser  Leu Asp Gln 
    1970                 1975                 1980             


Val Gln  Ala Ala Leu Thr Glu  Arg Asp Leu Tyr Ile  Tyr Ala Gly 
    1985                 1990                 1995             


His Gly  Ala Gly Ala Arg Phe  Leu Asp Gly Gln Ala  Val Leu Arg 
    2000                 2005                 2010             


Leu Ser  Cys Arg Ala Val Ala  Leu Leu Phe Gly Cys  Ser Ser Ala 
    2015                 2020                 2025             


Ala Leu  Ala Val His Gly Asn  Leu Glu Gly Ala Gly  Ile Val Leu 
    2030                 2035                 2040             


Lys Tyr  Ile Met Ala Gly Cys  Pro Leu Phe Leu Gly  Asn Leu Trp 
    2045                 2050                 2055             


Asp Val  Thr Asp Arg Asp Ile  Asp Arg Tyr Thr Glu  Ala Leu Leu 
    2060                 2065                 2070             


Gln Gly  Trp Leu Gly Ala Gly  Pro Gly Ala Pro Phe  Leu Tyr Tyr 
    2075                 2080                 2085             


Ala Ser  Gln Ala Arg Gln Ala  Pro Arg Leu Lys Tyr  Leu Ile Gly 
    2090                 2095                 2100             


Ala Ala  Pro Val Ala Tyr Gly  Leu Pro Ile Ser Leu  Gln Thr Pro 
    2105                 2110                 2115             


<210> 8
<211> 1262
<212> PRT
<213> Caenorhabditis elegans

<400> 8
Met Lys Ile Thr Asn Lys Ser Val Asp Lys Gln His Ile Glu Lys Leu 
1               5                   10                  15      


Asp Glu Leu Arg Lys Asn Val Ser Cys Thr Val Ile Gly Phe Ala Glu 
            20                  25                  30          


Gln Thr Ala Glu Leu Gln Gln Glu Ile Ser Glu Leu Phe Ile Ala Glu 
        35                  40                  45              


Phe Gly Val Asn Gly Pro Ile Asp Met Asn Ser Leu Ser Lys Leu Ala 
    50                  55                  60                  


Arg Ile Thr Ser Tyr Tyr Ala Ser Ser Glu Tyr Phe Gln Gly Leu Ala 
65                  70                  75                  80  


Lys Tyr Gln Arg Thr Ala Cys Lys Met Phe Ile Thr Trp Gln Thr Leu 
                85                  90                  95      


Arg Lys Glu Ala Met Glu Cys Arg Ser Lys Asp Arg Glu Ile Phe Ala 
            100                 105                 110         


Ser Ile Pro Ala Lys Leu Cys Phe Phe Tyr Phe Tyr Asn Gly Glu Leu 
        115                 120                 125             


Cys Arg Ala Val Val Cys Leu Leu Asp Tyr Ile Asp Leu Ser Asp Asp 
    130                 135                 140                 


Thr Leu Ala Lys Glu Ala Ala Leu Arg Trp Leu Met Phe Leu Gly Glu 
145                 150                 155                 160 


Thr Glu Leu Ile Glu Lys Lys Leu Lys Thr Trp Lys Met Asp Lys Ser 
                165                 170                 175     


Ser Lys Asp Met Phe Ser Ala Thr Glu Phe Ala Met Asn Tyr Leu Lys 
            180                 185                 190         


Lys Ser Glu Tyr Arg Val Glu Met Leu Glu Lys Leu Met Lys Leu Arg 
        195                 200                 205             


Asp Lys Val Lys Ser Asp Pro Thr Arg Ser Phe Ser Arg Tyr Glu Leu 
    210                 215                 220                 


Ala Ser Tyr Val Ser Trp Leu Cys Ser Thr Leu Ser Asn Val Pro Val 
225                 230                 235                 240 


Gly Ser Ala Leu Arg Glu Cys Glu Phe Pro Asp Arg Val Ser His Ile 
                245                 250                 255     


Gln Glu Ala Ala Leu Lys Ser Asp Ser Leu Val Arg Asn Arg Ile Pro 
            260                 265                 270         


Gly Leu Ala Ser Ser Gln Phe Asp Asn Ser Val Asn Ala Ser Ile Trp 
        275                 280                 285             


Pro Phe Leu Asp Gly His Gln Glu Asp Ser Asn Tyr Tyr Val His Ile 
    290                 295                 300                 


Gly Ser Thr Ile Ala Trp His Phe Glu Met Arg Arg Glu Cys Ala Leu 
305                 310                 315                 320 


Val Asn Val Thr Thr Ala Gln Thr Arg Asp Ser Met Ser Ala Met Ile 
                325                 330                 335     


Leu Asn Leu Arg Val Ala Leu Lys Ser Ala Ser Phe Phe Arg Val Leu 
            340                 345                 350         


Gln Thr Thr Asn Thr Leu Ala Tyr Tyr Ser Ser Ile Ile Glu Glu Ala 
        355                 360                 365             


Gly Ser Glu Lys Asn Ala Lys Leu Met Arg Val Ser Cys Val Asn Leu 
    370                 375                 380                 


Leu Ser Ser Asn Pro Ile Ile Val Arg Cys Ser Thr Pro Lys Glu Thr 
385                 390                 395                 400 


Gly Ala Thr Ser Arg Ala His Thr Pro Met Ala Gly Ser Ser Val Ser 
                405                 410                 415     


Glu Lys Gln Asn Thr Met Arg Pro Asp Leu Ala Asp Leu Leu Gly Asp 
            420                 425                 430         


Leu Glu Leu Leu Asp Glu Gln Ser Phe His Pro Ile Thr Arg Ser Cys 
        435                 440                 445             


Val Cys Asn Val Cys Thr Ile Tyr Pro Leu His Ser Ser Phe Ala Ala 
    450                 455                 460                 


Glu Tyr Met Met Ser Tyr Ala Ile His Ser Asp Phe Ser Gln Leu Ser 
465                 470                 475                 480 


Ile Lys His Phe Asn Asp Glu Phe Ala Arg Ile Arg Glu Arg Gly Met 
                485                 490                 495     


Ser Ser Gln Val Leu Met His Arg Asp Ser Ser Val Arg Pro Arg Pro 
            500                 505                 510         


Asn Ile Ile Gln Asn Glu Ile Phe Gly Met Cys Val Ile Arg Trp Leu 
        515                 520                 525             


Thr Lys Lys Leu Asp Ser Lys Glu Ser Ala Asp Glu Asp Thr Met Glu 
    530                 535                 540                 


Ile Phe Asn Asn Ala Leu Lys Ile Val Arg Tyr Leu Gln Gln Arg Thr 
545                 550                 555                 560 


Thr Asp Met Ile Leu Ala Val Thr Gln Leu Gly Arg Gln Leu Glu Phe 
                565                 570                 575     


Pro Met Glu Cys Asn Tyr Ser Trp Met Arg Pro Thr Ile Arg Lys Pro 
            580                 585                 590         


Arg Val Lys Ala Thr Ile Asp Cys Ala Val Asp Ile Leu Arg Ala Val 
        595                 600                 605             


Ser Pro Phe Gly Arg Arg Pro Lys Val Glu Lys Leu Glu Lys Asn Leu 
    610                 615                 620                 


Gln Pro Phe Asp Lys Glu Arg Phe Glu Lys Val Arg Leu Ala Met Arg 
625                 630                 635                 640 


Asn Glu Met Asn His Tyr Gly His Ile Leu Tyr Arg Glu Trp Arg Cys 
                645                 650                 655     


Arg Leu Phe Ala Tyr Val Gly Arg Thr Ser Arg Asp Pro Trp Glu Ala 
            660                 665                 670         


Ala Tyr Ala Trp Ala Glu Ser Thr Gln Ile Gly Ala Arg Asn Ala Val 
        675                 680                 685             


Gln Ser Arg Leu Glu Lys Cys Lys Arg Gly Leu Val Thr Met Ser Gly 
    690                 695                 700                 


His Asp Arg Phe Lys Thr Cys Val Gln Ser Met Pro Asp Glu Met Thr 
705                 710                 715                 720 


Leu Val Gln Ile Ala Met Ala Asp Asp Lys Thr Ile Tyr Leu Val Lys 
                725                 730                 735     


Leu His Ala Asp Arg Asp Pro Ile Ile Met Pro Leu Ala His Tyr Ser 
            740                 745                 750         


Gln Ala Val Glu Leu Met Asp Lys Phe Thr Phe Leu Leu Asp Glu Asp 
        755                 760                 765             


Glu Met Ile Ala Lys Tyr Pro Gly Asp Ile Thr Pro Glu Glu Phe Trp 
    770                 775                 780                 


Lys Arg Arg Lys Ile Val Asp Gly Arg Met Met Thr Phe Val Asp Glu 
785                 790                 795                 800 


Val Gln Lys His Phe Leu Gly Val Ala Ala Ser Leu Leu Met Pro Ser 
                805                 810                 815     


Gly Gln Leu Gly Pro Lys Ala Ala Glu Leu Ala Ile Lys Ile His Lys 
            820                 825                 830         


Leu Ser Lys Gly Gly Leu Leu Leu Gly Glu Ala Lys Glu Met Val Tyr 
        835                 840                 845             


Gln Ser Lys Leu Met Asp Ala Lys Ser Trp Glu Ala Leu Ile Leu Arg 
    850                 855                 860                 


Phe Cys Glu Met Arg Thr Thr Asp Glu Lys Phe Lys Ser Phe Leu Pro 
865                 870                 875                 880 


Leu Met His Arg Asn Ser Val Glu Val Met Asn Gln Asp Asp Ser Ile 
                885                 890                 895     


Val Thr Glu Lys Lys Tyr Thr Tyr Leu Val Ile Cys Pro His Leu Ser 
            900                 905                 910         


Gln Phe Cys Trp Glu Arg Leu Pro Ile Phe Asp Glu Tyr Pro Tyr Val 
        915                 920                 925             


Gly Arg Gln Val Ser Ile His Ser Thr Phe Ser Gln Leu Glu Ala Met 
    930                 935                 940                 


Lys Ser Gln Glu Lys Gln Ile Pro Leu Gln Ile Asp Val Gln Asn Ala 
945                 950                 955                 960 


Tyr Tyr Ile Leu Asp Pro Asp Asn Asn Leu Gly Glu Thr Gln Lys Arg 
                965                 970                 975     


Met Val Glu Tyr Ile Asn Lys Phe Asn Trp Glu Gly Thr Val Gly Ser 
            980                 985                 990         


Ala Pro Lys Ser Asn Glu Ile Ser  Ala Ala Leu Ser Gln  Arg Asp Ala 
        995                 1000                 1005             


Phe Phe  Phe Ile Gly His Gly  Ser Gly Ser Ser Val  Met Pro Arg 
    1010                 1015                 1020             


Ser Val  Leu Lys Gln Ser Thr  Cys Asn Ala Ile Ser  Leu Leu Met 
    1025                 1030                 1035             


Gly Cys  Gly Ser Val Arg Thr  Ile Pro Gln Ala Leu  Gly Phe Asp 
    1040                 1045                 1050             


Gly Lys  Thr Ala Ile Leu Asp  Tyr Ala Met Ala Lys  Cys Pro Leu 
    1055                 1060                 1065             


Ile Val  Gly Cys Leu Trp Thr  Val Thr Asp Gly Glu  Ile Asp Arg 
    1070                 1075                 1080             


Phe Leu  Ile Arg Met Ile Asp  Asp Cys Phe Glu Asp  Ser Lys Ser 
    1085                 1090                 1095             


Leu Thr  Gly Ile Asp Lys Leu  Arg Gln Leu Ser Glu  Ala Met His 
    1100                 1105                 1110             


Glu Ala  Arg Ser Lys Ala Arg  Leu Lys Tyr Leu Thr  Gly Ala Ala 
    1115                 1120                 1125             


Val Val  Met Tyr Gly Leu Pro  Val Val Ala Lys Gln  Thr Thr Pro 
    1130                 1135                 1140             


Phe Val  Glu Lys Asp Gln Arg  Asn Leu Pro Gln Thr  Pro Lys Thr 
    1145                 1150                 1155             


Ser Ala  Arg Thr Ser Met Arg  Met Glu Thr Val Pro  Lys Thr Pro 
    1160                 1165                 1170             


Lys Gln  Glu Phe Val Thr Ser  Lys Ser Val Pro Met  Thr Pro Ile 
    1175                 1180                 1185             


Phe Ser  Asn Asn Glu Asn Lys  Ser Pro Ser Arg Ala  Arg Met Pro 
    1190                 1195                 1200             


Ser Arg  Val Leu Lys Thr Pro  Arg Gln Val Lys Thr  Phe Gln Glu 
    1205                 1210                 1215             


Glu Asp  Asp Glu Ala Pro Lys  Arg Ser Thr Thr Arg  Gln Leu Lys 
    1220                 1225                 1230             


Pro Leu  Val Ala Pro Pro Ile  Pro Ala Thr Pro Thr  Thr Arg Thr 
    1235                 1240                 1245             


Thr Arg  Ser Ser Ala Arg Thr  Pro Ser Arg Ser Arg  Asn Leu 
    1250                 1255                 1260         


<210> 9
<211> 1630
<212> PRT
<213> Saccharomyces cerevisiae

<400> 9
Met Met Val Lys Gln Glu Glu Pro Leu Asn Glu Ile Ser Pro Asn Thr 
1               5                   10                  15      


Pro Met Thr Ser Lys Ser Tyr Leu Leu Asn Asp Thr Leu Ser Lys Val 
            20                  25                  30          


His His Ser Gly Gln Thr Arg Pro Leu Thr Ser Val Leu Ser Gly Asp 
        35                  40                  45              


Ala Ser Ser Asn Ser Ile Gly Ile Leu Ala Met His Asn Asn Ile Ile 
    50                  55                  60                  


Arg Asp Phe Thr Lys Ile Ala Ser Asn Asn Ile Asp Leu Ala Ile Glu 
65                  70                  75                  80  


Asp Ile Thr Thr Val Asp His Ser Leu Asn Ser Ile Tyr Ser Leu Leu 
                85                  90                  95      


Lys Ser His His Met Trp Gly His Ile Asn Ser Thr Val Lys Gln His 
            100                 105                 110         


Leu Met Ile Ile Val Lys Leu Ile Asn Asn Asn Ala Leu Gly Leu Ala 
        115                 120                 125             


Ser Ser Glu Ile Ile Phe Leu Phe Asn Glu Thr Asn Leu Phe Gln Ala 
    130                 135                 140                 


His Ser Leu Lys Asn Ile Leu Leu Ala Asp Phe Ser Thr Trp Asn Asp 
145                 150                 155                 160 


Tyr Tyr Leu Ser Asn Leu Lys Ile Leu Ala Leu Gln Ile Ile Leu Lys 
                165                 170                 175     


Arg Lys Leu Val Asp Glu Tyr Leu Pro His Ile Leu Glu Leu Phe Ser 
            180                 185                 190         


His Asp Lys Arg Tyr Leu Leu Lys Asp Pro Asn Leu Lys Ala His Ala 
        195                 200                 205             


Leu Thr Lys Ile Val Leu Ser Phe Phe Ser Val Thr Thr Ser Cys Lys 
    210                 215                 220                 


Val Leu Phe Gly Leu Lys Phe Leu Gln Tyr Ile Lys Gln Phe Lys Leu 
225                 230                 235                 240 


Pro Phe Lys Lys Phe Ile Ser Asn Ile Thr Val Glu Cys Phe Ser Lys 
                245                 250                 255     


Asn Leu Leu His Lys Asn Tyr Leu Glu Met Gly Pro Asn Lys Ile Tyr 
            260                 265                 270         


Leu Asn Ser Phe Tyr Leu Ser Tyr Ser Met Leu Tyr Asp Gly Leu Asp 
        275                 280                 285             


Lys Ile Met Leu Leu Asp Ile Leu Ser Tyr Glu Glu Thr Thr Glu Val 
    290                 295                 300                 


Gln Arg Ala Ile Lys Ser Lys Lys Glu Phe Asn Glu Tyr Cys Asn Met 
305                 310                 315                 320 


Ser Glu Asn Arg Leu Leu Trp Ser Cys Ile Ser Val Asp Asp Leu Asn 
                325                 330                 335     


Val Ile Leu Glu Asn Ala Thr Asn Phe Leu Gln Asn Lys Gly Lys His 
            340                 345                 350         


Ile Ser Ala Thr Leu Lys Cys Leu Val Cys Leu Trp Ser Thr Ile Arg 
        355                 360                 365             


Leu Glu Gly Leu Pro Lys Asn Lys Asp Ile Leu Arg Gln Phe Asp Cys 
    370                 375                 380                 


Thr Val Ile Tyr Ile Asn Ser Asn Ile Lys Ser Ile Asn Asp Glu Ser 
385                 390                 395                 400 


Ala Ala Ala Leu Leu Ser Glu Leu Leu Gly Val Leu Ser Glu Ile Cys 
                405                 410                 415     


Ile Asp Tyr Lys Glu Pro Lys Arg Leu Ser Asn Ile Ile Ser Val Leu 
            420                 425                 430         


Phe Asn Ala Ser Val Leu Phe Lys Ser His Ser Phe Leu Leu Lys Thr 
        435                 440                 445             


Ala Asn Leu Glu Ile Ser Asn Val Leu Ile Ser Asn Asp Ser Lys Thr 
    450                 455                 460                 


Ser His Arg Thr Ile Leu Lys Phe Glu Lys Phe Ile Ser Ser Ala Gln 
465                 470                 475                 480 


Ser Ala Gln Lys Lys Ile Glu Ile Phe Ser Cys Leu Phe Asn Val Tyr 
                485                 490                 495     


Cys Met Leu Arg Asn Asp Thr Leu Ser Phe Val Phe Asp Phe Cys Gln 
            500                 505                 510         


Asn Ala Phe Ile His Cys Phe Thr Arg Leu Lys Ile Thr Lys Phe Ile 
        515                 520                 525             


Glu Phe Ser Asn Ser Ser Glu Ile Met Leu Ser Val Leu Tyr Gly Asn 
    530                 535                 540                 


Ser Ser Ile Glu Asn Ile Pro Ser Glu Asn Trp Ser Gln Leu Ser Arg 
545                 550                 555                 560 


Met Ile Phe Cys Ser Leu Arg Gly Ile Phe Asp Leu Asp Pro Leu Glu 
                565                 570                 575     


Leu Asn Asn Thr Phe Asp Lys Leu His Leu Leu Asn Lys Tyr Glu Leu 
            580                 585                 590         


Leu Ile Arg Ile Val Tyr Leu Leu Asn Leu Asp Met Ser Lys His Leu 
        595                 600                 605             


Thr Thr Asn Leu Ser Lys Ile Thr Lys Leu Tyr Ile Asn Lys Trp Leu 
    610                 615                 620                 


Gln Lys Ser Asp Glu Lys Ala Glu Arg Ile Ser Ser Phe Glu Met Asp 
625                 630                 635                 640 


Phe Val Lys Met Leu Leu Cys Tyr Leu Asn Phe Asn Asn Phe Asp Lys 
                645                 650                 655     


Leu Ser Ile Glu Leu Ser Leu Cys Ile Lys Ser Lys Glu Lys Tyr Tyr 
            660                 665                 670         


Ser Ser Ile Val Pro Tyr Ala Asp Asn Tyr Leu Leu Glu Ala Tyr Leu 
        675                 680                 685             


Ser Leu Tyr Met Ile Asp Asp Ala Leu Met Met Lys Asn Gln Leu Gln 
    690                 695                 700                 


Lys Thr Met Asn Leu Ser Thr Ala Lys Ile Glu Gln Ala Leu Leu His 
705                 710                 715                 720 


Ala Ser Ser Leu Ile Asn Val His Leu Trp Asp Ser Asp Leu Thr Ala 
                725                 730                 735     


Phe Gln Ile Tyr Phe Gly Lys Thr Leu Pro Ala Met Lys Pro Glu Leu 
            740                 745                 750         


Phe Asp Ile Asn Asn Asp His Asn Leu Pro Met Ser Leu Tyr Ile Lys 
        755                 760                 765             


Val Ile Leu Leu Asn Ile Lys Ile Phe Asn Glu Ser Ala Lys Leu Asn 
    770                 775                 780                 


Ile Lys Ala Gly Asn Val Ile Ser Ala Val Ile Asp Cys Arg Lys Ala 
785                 790                 795                 800 


Gln Asn Leu Ala Leu Ser Leu Leu Lys Lys Lys Asn Lys Leu Ser Gln 
                805                 810                 815     


Gly Ser Arg Leu Ala Leu Leu Lys Ser Leu Ser Phe Ser Phe Phe Gln 
            820                 825                 830         


Leu Ile Lys Ile His Ile Arg Ile Gly Ser Ala Arg Asp Cys Glu Phe 
        835                 840                 845             


Tyr Ser Lys Glu Leu Ser Arg Ile Ile Ser Asp Leu Glu Glu Pro Ile 
    850                 855                 860                 


Ile Val Tyr Arg Cys Leu His Phe Leu His Arg Tyr Tyr Met Ile Thr 
865                 870                 875                 880 


Glu Gln Thr Cys Leu Gln Asn Ile Thr Leu Gly Lys Ala Asn Lys Ala 
                885                 890                 895     


Phe Asp Tyr Leu Asp Ala Glu Ala Asp Ile Thr Ser Leu Thr Met Phe 
            900                 905                 910         


Leu Tyr Asp Asn Lys Glu Phe Val Lys Leu Glu Gln Ser Leu Val Leu 
        915                 920                 925             


Tyr Phe Gly Asp Gln Leu Glu Lys Thr Phe Leu Pro Asn Leu Trp Lys 
    930                 935                 940                 


Leu His Leu Gly Lys Asp Ile Asp Asp Ser Ile Cys Leu Ser Glu Tyr 
945                 950                 955                 960 


Met Pro Lys Asn Val Ile Asn Arg Val His Asn Met Trp Gln Lys Val 
                965                 970                 975     


Met Ser Gln Leu Glu Glu Asp Pro Phe Phe Lys Gly Met Phe Glu Ser 
            980                 985                 990         


Thr Leu Gly Ile Pro Ser Ser Leu  Pro Val Ile Pro Ser  Thr Met Pro 
        995                 1000                 1005             


Asn Asn  Ile Leu Lys Thr Pro  Ser Lys His Ser Thr  Gly Leu Lys 
    1010                 1015                 1020             


Leu Cys  Asp Ser Pro Arg Ser  Ser Ser Met Thr Pro  Arg Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Gln Lys Phe Asp  Arg Ile Ala Ala Ile  Ser Lys Leu 
    1040                 1045                 1050             


Lys Gln  Met Lys Glu Leu Leu  Glu Ser Leu Lys Leu  Asp Thr Leu 
    1055                 1060                 1065             


Asp Asn  His Glu Leu Ser Lys  Ile Ser Ser Leu Ser  Ser Leu Thr 
    1070                 1075                 1080             


Leu Thr  Ile Leu Ser Asn Ile  Thr Ser Ile His Asn  Ala Glu Ser 
    1085                 1090                 1095             


Ser Leu  Ile Thr Asn Phe Ser  Leu Thr Asp Leu Pro  Arg His Met 
    1100                 1105                 1110             


Pro Leu  Leu Phe Asp Lys Val  Leu Asn Asn Ile Asp  Asn Lys Asn 
    1115                 1120                 1125             


Tyr Arg  Glu Phe Arg Val Ser  Ser Leu Ile Ala Pro  Asn Asn Ile 
    1130                 1135                 1140             


Ser Thr  Ile Thr Glu Ser Ile  Arg Val Ser Ala Ala  Gln Lys Asp 
    1145                 1150                 1155             


Leu Met  Glu Ser Asn Leu Asn  Ile Asn Val Ile Thr  Ile Asp Phe 
    1160                 1165                 1170             


Cys Pro  Ile Thr Gly Asn Leu  Leu Leu Ser Lys Leu  Glu Pro Arg 
    1175                 1180                 1185             


Arg Lys  Arg Arg Thr His Leu  Arg Leu Pro Leu Ile  Arg Ser Asn 
    1190                 1195                 1200             


Ser Arg  Asp Leu Asp Glu Val  His Leu Ser Phe Pro  Glu Ala Thr 
    1205                 1210                 1215             


Lys Lys  Leu Leu Ser Ile Ile  Asn Glu Ser Asn Gln  Thr Thr Ser 
    1220                 1225                 1230             


Val Glu  Val Thr Asn Lys Ile  Lys Thr Arg Glu Glu  Arg Lys Ser 
    1235                 1240                 1245             


Trp Trp  Thr Thr Arg Tyr Asp  Leu Asp Lys Arg Met  Gln Gln Leu 
    1250                 1255                 1260             


Leu Asn  Asn Ile Glu Asn Ser  Trp Phe Asn Gly Val  Gln Gly Phe 
    1265                 1270                 1275             


Phe Ser  Pro Glu Val Val Asp  Asn Ser Leu Phe Glu  Lys Phe Lys 
    1280                 1285                 1290             


Asp Lys  Phe Tyr Glu Ile Leu  His Gln Asn Leu Pro  Ser Arg Lys 
    1295                 1300                 1305             


Leu Tyr  Gly Asn Pro Ala Met  Phe Ile Lys Val Glu  Asp Trp Val 
    1310                 1315                 1320             


Ile Glu  Leu Phe Leu Lys Leu  Asn Pro Gln Glu Ile  Asp Phe Leu 
    1325                 1330                 1335             


Ser Lys  Met Glu Asp Leu Ile  Tyr Phe Val Leu Asp  Ile Leu Leu 
    1340                 1345                 1350             


Phe His  Gly Glu Glu Asn Ala  Tyr Asp Glu Ile Asp  Phe Ser Met 
    1355                 1360                 1365             


Leu His  Val Gln Leu Glu Glu  Gln Ile Lys Lys Tyr  Arg Ala Thr 
    1370                 1375                 1380             


Met Thr  Thr Asn Ser Ile Phe  His Thr Phe Leu Val  Val Ser Ser 
    1385                 1390                 1395             


Ser Cys  His Leu Phe Pro Trp  Glu Cys Leu Ser Phe  Leu Lys Asp 
    1400                 1405                 1410             


Leu Ser  Ile Thr Arg Val Pro  Ser Tyr Val Cys Leu  Asn Lys Leu 
    1415                 1420                 1425             


Leu Ser  Arg Phe His Tyr Gln  Leu Pro Leu Gln Val  Thr Ile Glu 
    1430                 1435                 1440             


Asp Asn  Ile Ser Met Ile Leu  Asn Pro Asn Gly Asp  Leu Ser Arg 
    1445                 1450                 1455             


Thr Glu  Ser Lys Phe Lys Gly  Met Phe Gln Lys Ile  Ile Asp Ala 
    1460                 1465                 1470             


Lys Pro  Ser Ser Gln Leu Val  Met Asn Glu Lys Pro  Glu Glu Glu 
    1475                 1480                 1485             


Thr Leu  Leu Lys Met Leu Gln  Asn Ser Asn Leu Phe  Val Tyr Ile 
    1490                 1495                 1500             


Gly His  Gly Gly Gly Glu Gln  Tyr Val Arg Ser Lys  Glu Ile Lys 
    1505                 1510                 1515             


Lys Cys  Thr Lys Ile Ala Pro  Ser Phe Leu Leu Gly  Cys Ser Ser 
    1520                 1525                 1530             


Ala Ala  Met Lys Tyr Tyr Gly  Lys Leu Glu Pro Thr  Gly Thr Ile 
    1535                 1540                 1545             


Tyr Thr  Tyr Leu Leu Gly Gly  Cys Pro Met Val Leu  Gly Asn Leu 
    1550                 1555                 1560             


Trp Asp  Val Thr Asp Lys Asp  Ile Asp Lys Phe Ser  Glu Glu Leu 
    1565                 1570                 1575             


Phe Glu  Lys Met Gly Phe Arg  Cys Asn Thr Asp Asp  Leu Asn Gly 
    1580                 1585                 1590             


Asn Ser  Leu Ser Val Ser Tyr  Ala Val Ser Lys Ser  Arg Gly Val 
    1595                 1600                 1605             


Cys His  Leu Arg Tyr Leu Asn  Gly Ala Ala Pro Val  Ile Tyr Gly 
    1610                 1615                 1620             


Leu Pro  Ile Lys Phe Val Ser  
    1625                 1630 


<210> 10
<211> 1828
<212> PRT
<213> Schizosaccharomyces pombe

<400> 10
Met Ser Thr Arg Ser Ile Val Thr Ser Lys Val Ser Trp Thr Pro Glu 
1               5                   10                  15      


Lys Phe Ile Ser Ala Leu Ser Tyr Pro Glu His Cys Ser Ile Thr Leu 
            20                  25                  30          


Val Lys Arg Leu Lys Ala Ser Val Lys Leu Lys Asp Leu Lys Gln Asn 
        35                  40                  45              


Ile Ser Arg Asp Ala Pro Ser Trp Thr Phe Glu His Leu Phe Val Ala 
    50                  55                  60                  


Phe Lys Cys Ala Val Ser Asn Leu Ala Lys Gln Trp Ala Glu Leu Ser 
65                  70                  75                  80  


Thr Thr Asp Lys Glu Lys Thr Arg Arg Met Phe Cys Thr Pro Ser Arg 
                85                  90                  95      


Leu Asn Thr Ala His Arg Pro Glu Val Phe Tyr Leu Leu Glu Cys Cys 
            100                 105                 110         


Thr Tyr Ile Leu Glu Gln Met Gln Val Val Thr Lys Asn Thr Ser His 
        115                 120                 125             


Leu Tyr Asp Cys Ile Arg Ser Gly Val Ser Ile Cys Asn Arg Leu Leu 
    130                 135                 140                 


Asp Met Glu Ile Phe Glu Pro Ala Ile Ser Leu Leu Met Lys Thr His 
145                 150                 155                 160 


Lys Asn Leu Ile Ile Leu Leu Thr Tyr Arg Asp His Asp Ala Ile Pro 
                165                 170                 175     


Thr Ala Thr Leu Leu Asn Pro Thr Leu Asp Val Ser Glu Ile Gln Leu 
            180                 185                 190         


Glu Ser Cys Leu Phe Val Pro Met Val Pro Ala Ser Tyr Phe Leu Asn 
        195                 200                 205             


Ile Gly Thr Ile Val Val Thr Phe Gln Leu Asn Val Leu Arg Cys Leu 
    210                 215                 220                 


Ser Leu Ser Gln Ile Asn Gly Leu Ser Leu Asn Thr Ile Asn Asn Leu 
225                 230                 235                 240 


Gln Ser Glu Asp Gly Pro Phe Gln Trp Ile Glu Arg Ser Phe Pro Ser 
                245                 250                 255     


Gln Val Gln Leu Ala Asn Ser Arg Arg Glu Ile Leu Ala Arg Leu Leu 
            260                 265                 270         


Thr Arg Phe Ser Met Ile Gln Asn Asn Ala Leu Gln Ser Phe Lys Leu 
        275                 280                 285             


Leu Ile Leu Ser Ile Ala Leu Trp Leu Asn Ile Leu Ser Ser Gln Arg 
    290                 295                 300                 


Ala Asp Asp Lys Glu Phe Asp Val Asn Gln Leu Glu Thr Arg Ile Leu 
305                 310                 315                 320 


Gln Leu Phe Ser Lys Val Val Gln Leu Cys Lys Ser Glu Asp Ile Glu 
                325                 330                 335     


Gly Ser Ile Leu Asn Lys Asp Met Thr Gln Leu His His Leu Leu Glu 
            340                 345                 350         


Asn Leu Ser Lys Glu Ser Arg Leu His Ile Leu Leu Gln Leu Ser Gln 
        355                 360                 365             


Leu Tyr Tyr Lys Tyr Asn Asp Phe Gln Leu Ser Ala Ala Tyr Val Ile 
    370                 375                 380                 


Arg Gly Tyr Ser Leu Ser Phe Glu Asp Ile Ser Phe Lys Leu Lys Phe 
385                 390                 395                 400 


Leu Leu Phe Ser Phe Arg Leu Ser Ile His Asp Asn Ser Ile Cys Phe 
                405                 410                 415     


Pro Phe Asn Leu Ile Gln Glu Leu Ser Ser Leu Gln Gln Leu Phe Val 
            420                 425                 430         


Glu Asn Ala Leu Pro Tyr Ser Glu Ala Leu His Leu Leu Asp Ser Ile 
        435                 440                 445             


Glu Arg Ser Phe Arg Leu Phe Asn Asp Ser Thr Val Phe Asp Asp Thr 
    450                 455                 460                 


Val Phe Ala Leu Asn Ile Ser Glu Ile Leu Ser Trp Ile Leu Ser Ser 
465                 470                 475                 480 


Val Val Arg Asp Ile Leu Val Glu Asp Glu Leu Leu Asn Leu Gln Leu 
                485                 490                 495     


Lys Ile Arg Lys Phe Leu Met Phe Thr Phe His Ile Ile Arg Ser Phe 
            500                 505                 510         


Ser Glu Leu Thr Lys Phe Gln Ser Ser Leu Glu Gly Cys Leu Asn Leu 
        515                 520                 525             


Ala Ala Tyr Tyr Glu Asp Ala Glu Phe Pro Gln Lys Leu Ser Asn His 
    530                 535                 540                 


Leu Tyr Asn Leu Cys Val Lys Ser Ser Asn Val Asn Tyr Ala Arg Glu 
545                 550                 555                 560 


Cys Ile Ser Leu Ser Ile Lys Ile Ala Val Ser His Lys Leu Thr Asn 
                565                 570                 575     


Asp Glu Thr Tyr Leu Leu Lys Ile Leu Lys Asn Phe Gln Leu Arg Tyr 
            580                 585                 590         


His Asp Ser Leu Gln Leu Gln Glu Lys Cys Asp Val Leu His Thr Thr 
        595                 600                 605             


Phe Asn Gln Leu Asp Leu Tyr Val Gly Thr Thr Ser Val Gly Lys Ser 
    610                 615                 620                 


Ser Val Leu Asp Asn Ile Leu Lys Arg Ile Phe Asn Ser Leu Thr Ser 
625                 630                 635                 640 


Ile Asn Asp Ser Asn Ile Glu Lys Leu Leu Glu Ser Ile Ser Tyr Ser 
                645                 650                 655     


Leu Leu Lys Leu Phe Phe Lys Cys Ala Asn Glu Gly Ser Arg Tyr Asn 
            660                 665                 670         


Ala Ser Ala Ala Leu Ser Phe Lys Leu Ser Leu Met Leu His Glu Lys 
        675                 680                 685             


Glu Glu Val Leu Leu Leu Lys Thr Asn Val Ser Cys Val Leu Ala Asn 
    690                 695                 700                 


His Gly Tyr Asn Asp Ile Lys Phe Glu Glu Met Val Leu Cys Val Ile 
705                 710                 715                 720 


Lys Gly Asp Gln Asn Leu Leu Glu His Asn Ser Asn Asn Asn Ala Lys 
                725                 730                 735     


Leu Ala Leu Asn Glu Ser Leu Leu Cys Ser Trp Glu Asn Leu Leu Cys 
            740                 745                 750         


Tyr Arg Arg Ala Glu Asp Asp Ser Arg Ile Leu Thr Ile Ile Glu Ser 
        755                 760                 765             


Trp Thr Ile Phe Ile Ser Arg Phe Ser Ser Val Ile Ser Arg Cys Ser 
    770                 775                 780                 


Phe Thr Asp Phe Glu Ile Asn Ser Ile Leu Asn Phe Phe Phe Cys Phe 
785                 790                 795                 800 


Leu His Thr Val Glu Pro Ser Gly Lys Leu Thr Phe Glu Leu Ala Phe 
                805                 810                 815     


Leu Glu Ile Phe Tyr Glu Leu Phe Asn Cys Leu Leu His Leu Gln Phe 
            820                 825                 830         


Ser Lys Tyr Leu Val Ile Ile Gly Thr Leu Leu Ser Asp Lys Tyr Met 
        835                 840                 845             


Thr Leu Gly Phe Ser Gly Lys Ala His Leu Phe Tyr Thr Lys Cys Tyr 
    850                 855                 860                 


Ser Tyr Leu Arg Gln Cys Lys Ser Ser Pro Phe Ile Asn Phe Trp Asn 
865                 870                 875                 880 


Val Ser Tyr Gly Lys Tyr Leu Ile Leu Thr Gly Asn Thr Asp Lys Gly 
                885                 890                 895     


Ile Leu Gln Leu Lys Lys Tyr Ser Leu Ser Ser Glu Glu Asp Phe Asn 
            900                 905                 910         


Ser Asn Gly Leu Ser Arg Thr Val Ser Leu Asn Leu Leu Leu Tyr Glu 
        915                 920                 925             


Arg Ile Gln Leu Ser Asp Ala Leu Phe Gln Leu Gly Tyr Thr Thr Val 
    930                 935                 940                 


Ser Leu Gly Phe Ile Met Gln Asn Leu Lys Val Ile Lys Gly Leu Phe 
945                 950                 955                 960 


Ser Lys Ser Ser Lys Glu His Phe Asn Gly Gly Lys Tyr Ile Thr Trp 
                965                 970                 975     


Arg Leu Phe Ala Val Ser Ala His Ser Asn Val Cys Ala Ala Arg Ile 
            980                 985                 990         


Tyr Glu His Met Gly Gln Ala Arg  Glu Ala Glu Phe Phe  Tyr Arg Gln 
        995                 1000                 1005             


Ala Cys  Ser Ile Ser Glu Lys  Met Pro Phe Ser Cys  Phe Ser Ala 
    1010                 1015                 1020             


Thr Phe  Gln Leu Arg Leu Cys  Ser Leu Leu Thr Arg  Ala Gly Lys 
    1025                 1030                 1035             


Leu Glu  Lys Gly Glu Lys Ile  Leu Phe Asp Leu Thr  Glu Ala Met 
    1040                 1045                 1050             


Lys Ser  Thr Asp Thr Tyr His  Lys Leu Leu Trp Asn  Tyr Gly Ala 
    1055                 1060                 1065             


Ala Glu  Val Cys Ala Thr Lys  Ser Glu Leu Asp Gly  Ala Ile Cys 
    1070                 1075                 1080             


His Tyr  Ser Glu Cys Val Lys  Leu Leu Glu Ile Ile  Lys Ser Glu 
    1085                 1090                 1095             


Tyr Tyr  Leu Phe Phe Asn Arg  Asn Arg Glu Lys Ser  Leu Thr Lys 
    1100                 1105                 1110             


Gly Ile  Lys Arg Leu Ser Leu  Ser Ser Gln Pro Thr  Phe Val Thr 
    1115                 1120                 1125             


Glu Ser  Asn Thr Thr Glu Phe  Asp Asp Trp Ser Ile  Leu Gln Asn 
    1130                 1135                 1140             


Thr Ala  Ala Asn Leu Leu Arg  Leu Ile Ser Met Phe  Glu Leu Lys 
    1145                 1150                 1155             


Arg Gly  Asn Leu Glu Ile Ala  Lys Ala Leu Met Thr  Asp Ser Thr 
    1160                 1165                 1170             


Lys Cys  Ser Ile Ala Ser Phe  Phe Asn Ile Val Ser  Ala Asn Ile 
    1175                 1180                 1185             


Leu Lys  Ser Lys Leu Ile Val  Cys Glu Ala Asp Ser  Thr Leu Phe 
    1190                 1195                 1200             


Gly Asp  Pro Val Leu Arg Thr  Leu Pro Asp Ser Val  Ile Ser Leu 
    1205                 1210                 1215             


Pro Gly  Ile Ser His Lys Phe  Gln Lys Asn Gln Ser  Lys Thr Lys 
    1220                 1225                 1230             


Ala Leu  Gly Glu Asn Thr Gly  Phe Arg Lys Gly Ser  Lys Arg Leu 
    1235                 1240                 1245             


Asp Tyr  Leu Arg Glu Arg Leu  Lys Ile Asn Leu Gln  Asn Val Arg 
    1250                 1255                 1260             


Leu Ser  Cys Glu Ile Ile Phe  Ser Asn Ala Tyr Glu  Arg Ser Ser 
    1265                 1270                 1275             


Val Cys  Val Cys Arg Glu Val  Asn Glu Leu Ile Ser  Tyr Ser Thr 
    1280                 1285                 1290             


Ile Met  Gln Ser Ala Leu Thr  Thr Ile Gly Glu Thr  Thr Asp Val 
    1295                 1300                 1305             


Asp Ser  Ser Ser Ala Ser Phe  Phe Leu Glu Ile Pro  Lys Ala Leu 
    1310                 1315                 1320             


Gly Phe  His Arg Arg Arg Glu  Ala Gln Lys Phe Arg  Asn Gln His 
    1325                 1330                 1335             


Lys Glu  Leu His Phe Ser Ser  Leu Glu Gln Ile Leu  Asn Ser Arg 
    1340                 1345                 1350             


Leu Ser  Ile Pro Asp Val Arg  Thr Phe Gln Asp Asn  Phe Ile Asp 
    1355                 1360                 1365             


Ser Leu  Pro Ser Ile Trp Asn  Val Val Ser Ile Thr  Ile Asn Asn 
    1370                 1375                 1380             


Ser Gly  Glu Asp Leu Phe Ile  Ser Lys Ile Arg Lys  Gly His Ser 
    1385                 1390                 1395             


Pro Leu  Ile Phe Arg Leu Pro  Leu Gln Arg His Asn  Ser Arg Asp 
    1400                 1405                 1410             


Ala Asp  Glu Glu Ile Leu Val  Phe Thr Lys Ala Gln  Thr Glu Leu 
    1415                 1420                 1425             


Phe Arg  Ile Ile Ser Lys Ser  Asn Gln Met Ala Gln  Asn Gly Lys 
    1430                 1435                 1440             


His Tyr  Thr Arg Arg Glu Asp  Lys Glu Thr Trp Trp  Lys Glu Arg 
    1445                 1450                 1455             


Arg His  Leu Asp Gln Cys Leu  Gln Gln Leu Leu Glu  Asn Ile Glu 
    1460                 1465                 1470             


Ile Ser  Trp Leu Gly Gly Phe  Lys Gly Ile Phe Asn  Pro His Lys 
    1475                 1480                 1485             


Ile Asp  Thr Ser Leu Phe Ala  Lys Phe Ser Ser Gln  Phe Gln Asn 
    1490                 1495                 1500             


Ile Ile  Ala Lys Asn Phe Asn  Met Asp Lys Lys Thr  Pro Val Pro 
    1505                 1510                 1515             


Thr Leu  Ser Pro Glu Ile Leu  Glu Leu Phe Ile Thr  Leu Gly Lys 
    1520                 1525                 1530             


Pro Gly  Tyr Glu Gly Tyr Glu  Gln Leu Leu Glu Asp  Leu Ile Tyr 
    1535                 1540                 1545             


Phe Ile  Leu Asp Ile Phe Gln  Phe Arg Gly Leu His  Phe Ala Tyr 
    1550                 1555                 1560             


Asp Glu  Ile Asp Thr Asp Gln  Leu Ser Met Asp Leu  Gln Asp Ala 
    1565                 1570                 1575             


Leu Asn  Ala Tyr Phe Asn Asn  Tyr Val Ser Glu Glu  Asn Arg Ser 
    1580                 1585                 1590             


His Thr  Val Leu Val Leu Asp  Lys Ser Val His Gln  Phe Pro Trp 
    1595                 1600                 1605             


Glu Ser  Leu Pro Cys Leu Asn  Arg Gln Ser Val Ser  Arg Val Pro 
    1610                 1615                 1620             


Ser Leu  Ser Ile Leu Arg Asp  Ile Leu Ser Gln Ser  Phe Val Val 
    1625                 1630                 1635             


Asn Gly  Glu Tyr Val Glu Val  Arg Lys Glu Ala Gly  Ser Tyr Ile 
    1640                 1645                 1650             


Leu Asn  Pro Ser Leu Asp Leu  Lys His Thr Gln Glu  Met Phe Glu 
    1655                 1660                 1665             


His Lys  Leu Val Glu Gly Gly  Trp Lys Gly Leu Ile  Ala Ser Gln 
    1670                 1675                 1680             


Pro Ser  Asn Arg Asp Phe Ile  Lys Met Leu Ser Gly  Asn Asp Phe 
    1685                 1690                 1695             


Phe Leu  Tyr Phe Gly His Gly  Gly Gly Glu Gln Tyr  Thr Thr Ser 
    1700                 1705                 1710             


Tyr Asp  Leu Ala Thr Leu Lys  Arg Cys Ala Val Thr  Ile Leu Met 
    1715                 1720                 1725             


Gly Cys  Ser Ser Gly Ala Leu  Tyr Glu Cys Gly Ser  Phe Glu Pro 
    1730                 1735                 1740             


Trp Gly  Thr Pro Leu Asp Tyr  Leu Ser Ala Gly Cys  Pro Thr Leu 
    1745                 1750                 1755             


Val Ala  Asn Leu Trp Asp Val  Thr Asp Lys Asp Ile  Asp Arg Phe 
    1760                 1765                 1770             


Ser Leu  Lys Met Leu Glu Ser  Trp Gly Leu Phe Glu  Asn Lys Ala 
    1775                 1780                 1785             


Pro Phe  Val Asn Ser Thr Ser  Ile Cys Thr Ala Val  Ser Glu Ser 
    1790                 1795                 1800             


Arg Ser  Cys Cys His Leu Arg  Tyr Leu Asn Gly Ala  Ala Pro Val 
    1805                 1810                 1815             


Ile Tyr  Gly Ile Pro Ala Tyr  Ile Ile Pro 
    1820                 1825             


<210> 11
<211> 199
<212> PRT
<213> Mus musculus

<400> 11
Met Ala Thr Leu Ile Phe Val Asp Lys Asp Asn Glu Glu Pro Gly Arg 
1               5                   10                  15      


Arg Leu Ala Ser Lys Asp Gly Leu Lys Leu Gly Thr Gly Val Lys Ala 
            20                  25                  30          


Leu Asp Gly Lys Leu Gln Val Ser Thr Pro Arg Val Gly Lys Val Phe 
        35                  40                  45              


Asn Ala Pro Ala Val Pro Lys Ala Ser Arg Lys Ala Leu Gly Thr Val 
    50                  55                  60                  


Asn Arg Val Ala Glu Lys Pro Met Lys Thr Gly Lys Pro Leu Gln Pro 
65                  70                  75                  80  


Lys Gln Pro Thr Leu Thr Gly Lys Lys Ile Thr Glu Lys Ser Thr Lys 
                85                  90                  95      


Thr Gln Ser Ser Val Pro Ala Pro Asp Asp Ala Tyr Pro Glu Ile Glu 
            100                 105                 110         


Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu Ser Phe Asp Leu Pro 
        115                 120                 125             


Glu Glu His Gln Ile Ser Leu Leu Pro Leu Asn Gly Val Pro Leu Met 
    130                 135                 140                 


Thr Leu Asn Glu Glu Arg Gly Leu Glu Lys Leu Leu His Leu Gly Pro 
145                 150                 155                 160 


Pro Ser Pro Leu Lys Thr Pro Phe Leu Ser Trp Glu Ser Asp Pro Leu 
                165                 170                 175     


Tyr Ser Pro Pro Ser Ala Leu Ser Thr Leu Asp Val Glu Leu Pro Pro 
            180                 185                 190         


Val Cys Tyr Asp Ala Asp Ile 
        195                 


<210> 12
<211> 244
<212> PRT
<213> Caenorhabditis elegans

<400> 12
Met Glu Asp Leu Asn Phe Glu Glu Arg Gly Ser Thr Gln Ile Pro Ala 
1               5                   10                  15      


Ser Leu Gln Gln His Phe Ser Ala Lys Leu Gly Arg Gln Asn Glu Leu 
            20                  25                  30          


Glu Lys Thr Pro Ser Arg Gly Gly Leu Gly Leu Val Val Asn Ser Ser 
        35                  40                  45              


Lys Thr Pro Gly Gly Lys Ser Leu Gln Ser Leu Ala Ser Ala Cys Lys 
    50                  55                  60                  


Val Pro Pro Ser Thr Lys Lys Asn Thr Ile Pro Ile Ala Phe Glu Cys 
65                  70                  75                  80  


Tyr Glu Asp Glu Thr Asp Asp Gln Ile Ala Asp Val Ala Thr Ile Lys 
                85                  90                  95      


Lys Thr Glu Lys His Pro Cys Ser Pro Ile Asp Thr Ala Asn Arg Cys 
            100                 105                 110         


Glu Thr Phe Asp Ser Leu Ala Ala Asp Ile Glu Asp Asp Met Leu Asn 
        115                 120                 125             


Leu Glu Asp Gln Asp Val Val Leu Ser Glu Asp Arg Pro Tyr Gly Asp 
    130                 135                 140                 


Val Ile Asp Pro Ala Glu Ser Glu Ala Glu Ala Leu Ala Glu Leu Gly 
145                 150                 155                 160 


Val Glu Glu Trp Asp Ser Tyr Pro Pro Ile Asp Pro Ala Ser Arg Ile 
                165                 170                 175     


Gly Asp Asp Phe Asn Tyr Val Leu Arg Thr Glu Asp Phe Ala Glu Glu 
            180                 185                 190         


Gly Asp Val Lys Leu Glu Glu Thr Arg His Arg Thr Val Ile Ala Asp 
        195                 200                 205             


Ile Asp Glu Val Lys Met Ser Lys Ala Glu Arg Asn Glu Leu Phe Ser 
    210                 215                 220                 


Met Leu Ala Asp Asp Leu Asp Ser Tyr Asp Leu Leu Ala Glu Glu Ala 
225                 230                 235                 240 


Asn Leu Pro Leu 
                


<210> 13
<211> 373
<212> PRT
<213> Saccharomyces cerevisiae

<400> 13
Met Met Pro Ala Asn Glu Asp Lys Glu Asn Asn Ile Val Tyr Thr Gly 
1               5                   10                  15      


Asn Glu Ser Ser Gly Ile Asn Phe Pro Gln Thr Pro Ala His Leu Leu 
            20                  25                  30          


Lys Arg Ser His Ser Asn Ile Leu Lys Pro Pro Val Arg Leu Asp Gln 
        35                  40                  45              


Leu Lys Arg Asp Ala Asn Ser Asn Asn Gly Asn Thr Leu Lys Tyr Ile 
    50                  55                  60                  


Gln Gly Gly Lys Glu Val Ser Pro Thr Lys Arg Leu His Thr His Ala 
65                  70                  75                  80  


Gln Gln Gln Gly Arg Leu Pro Leu Ala Ala Lys Asp Asn Asn Arg Ser 
                85                  90                  95      


Lys Ser Phe Ile Phe Pro Glu Thr Ser Asn Gln Ser Lys Asp Ala Asp 
            100                 105                 110         


Leu Pro Gln Leu Gln Asn Thr Leu Ser Ile Arg Lys Asn Asp Gln Leu 
        115                 120                 125             


Arg Lys Leu Ser Gln Ile Ser Arg Ser Arg Ser Arg Ala Asn His Asn 
    130                 135                 140                 


Asp Leu Leu Ser Asn Ser Arg Lys Leu Gln Lys Tyr Gly Ser Val Leu 
145                 150                 155                 160 


Gly Tyr Asn Ala Leu Pro Lys Met Lys Ser Leu Val Leu Lys Asp Leu 
                165                 170                 175     


Ala Asp Ser Gly Lys Asn Glu Glu Ser Ser Asp Asp Asp Glu Gly Asn 
            180                 185                 190         


Glu Asp Ser Glu Ser Lys Leu Gly Lys Lys Leu Gln Ser Ala Leu Leu 
        195                 200                 205             


Lys Gln Asp Ser Ser Asp Gly Glu Asn Glu Leu Asn Gly Gly Leu Gly 
    210                 215                 220                 


Leu Phe Asn Glu Gln Gly Gly Leu Gln Gln Leu Ile Lys Asn Ser Thr 
225                 230                 235                 240 


Lys Asn Glu Gln Lys Thr Lys Asn Asp Lys Ser Asp Lys Thr Asp Asp 
                245                 250                 255     


Tyr Asp Ile Glu Ile Ala Pro Gln Arg Gln Glu Pro Leu Pro Tyr Val 
            260                 265                 270         


Pro Glu Gly Tyr Ser Pro Phe Gln Gln Asp Asp Ile Glu Lys Leu Lys 
        275                 280                 285             


Thr Phe Asn Ser Pro Tyr Lys Leu Asp Leu Glu Asp Glu Asp Asp Thr 
    290                 295                 300                 


Pro Asp Lys Val Asp Leu Leu Pro Leu Glu Gln Ile Asp Glu Glu Gly 
305                 310                 315                 320 


Glu Lys Asp Glu Thr Glu Cys Ile Thr Arg Asn Gln Glu Glu Gly Ala 
                325                 330                 335     


Ala Leu Pro Leu Leu Ser Lys Asn Phe Lys Glu Val Ala Ala Val Pro 
            340                 345                 350         


Thr Met Glu Leu Val Tyr Ser Glu Glu Gly Leu Asp Pro Glu Glu Leu 
        355                 360                 365             


Glu Asp Leu Val Thr 
    370             


<210> 14
<211> 301
<212> PRT
<213> Schizosaccharomyces pombe

<400> 14
Met Leu Pro Arg Thr Met Phe Ser Tyr Gly Lys Glu Asn Ala Phe Pro 
1               5                   10                  15      


Val Thr Pro Ile Ser Asn Arg Asn Gly Thr Lys Gly Ala Gly Ser Lys 
            20                  25                  30          


Arg Ala Pro Leu Gly Ser Thr Lys Gln Ser Asn Ala Pro Ser Ser Val 
        35                  40                  45              


Thr Val Pro Arg Thr Val Leu Gly Gly Lys Ser Thr Asn Ile Ser Lys 
    50                  55                  60                  


Phe Ile Ser Ala Pro Ser Thr Lys Lys Met Ser Pro Met Asp Ile Ser 
65                  70                  75                  80  


Met Asp Ser Pro Thr Ile Leu Glu Pro Asn Ser Gln Gly Ile Ser Arg 
                85                  90                  95      


Ser Ala Val Gln Glu Arg Ser Lys Arg Leu Ser Ala Ser Pro Arg Arg 
            100                 105                 110         


Ser Ser Leu Thr Asp Thr Pro Leu Pro Asn Glu Leu Glu Glu Asp Ile 
        115                 120                 125             


Glu Tyr Met Pro Pro Pro Val His Leu Asp Pro Ile Gln Ser Leu Gly 
    130                 135                 140                 


Phe Asp Asp Val Ala Ile Asp Cys Glu Thr Leu Asp Pro Trp Pro Ser 
145                 150                 155                 160 


Met Gln Asn Lys Ala Thr Ser Val Thr Ile Arg Asn Thr Pro Ala Ser 
                165                 170                 175     


Asp Phe His Val Tyr Lys Glu Phe Ser Asp Asp Asp Pro Ile Gln Phe 
            180                 185                 190         


Pro Leu Leu Ser Val Asp Gly Asp Ser Pro Leu Thr Glu Lys Asp Thr 
        195                 200                 205             


Asn Leu Thr Thr Pro Ala Thr Leu Lys Ala Ser Asp Gln Gln Arg Lys 
    210                 215                 220                 


Val Leu Glu Lys Pro Ser Val Ser Lys Gln Ser Ser Ser Arg Thr Arg 
225                 230                 235                 240 


Leu Ser Thr Val Tyr Arg Thr Lys Leu Ala Ser Gly Lys Ser Ile Pro 
                245                 250                 255     


Arg Pro Leu Ser His Lys Leu Thr Arg Pro Arg Val Thr Ala Ser Gly 
            260                 265                 270         


Asn Ser Arg Arg Arg Pro Leu Ser Arg Ser Ile His Ser Leu Ser Ser 
        275                 280                 285             


Ser Arg Ile Asp Phe Ser Ser Leu Asp Thr Gly Leu Leu 
    290                 295                 300     


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Gly Gly Gly Ser 
1               5   


<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 17
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 18
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Gly Gly Gly Gly Gly 
1               5       


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15  


<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 22
His His His His His His 
1               5       


<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 24
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      unfoldase recognition site sequence

<400> 24
Thr Asn Thr Ala Lys Ile Leu Asn Phe Gly Arg 
1               5                   10      


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Asp Asp Arg Glu Ile Met Arg Glu Gly Ser 
1               5                   10  


<210> 26
<211> 7
<212> PRT
<213> Homo sapiens

<400> 26
Glu Ile Glu Lys Phe Phe Pro 
1               5           


<210> 27
<211> 4
<212> PRT
<213> Homo sapiens

<400> 27
Glu Ile Met Arg 
1               


<210> 28
<211> 4
<212> PRT
<213> Homo sapiens

<400> 28
Glu Pro Ser Arg 
1               


<210> 29
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Scc1 sequence

<400> 29
Pro Pro Ala Leu Ser Glu Ala Gly Val Met Leu Pro Glu Gln Pro Ala 
1               5                   10                  15      


His Asp Asp Met Asp 
            20      


<210> 30
<211> 30
<212> PRT
<213> Homo sapiens

<400> 30
Tyr Pro Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu 
1               5                   10                  15      


Ser Phe Asp Leu Pro Glu Glu His Gln Ile Ala His Leu Pro 
            20                  25                  30  


<210> 31
<211> 30
<212> PRT
<213> Mus musculus

<400> 31
Tyr Pro Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu 
1               5                   10                  15      


Ser Phe Asp Leu Pro Glu Glu His Gln Ile Ser Leu Leu Pro 
            20                  25                  30  


<210> 32
<211> 30
<212> PRT
<213> Gallus gallus

<400> 32
Tyr Pro Glu Ile Glu Asn Leu Phe Pro Ser Asp Pro Leu Asp Leu Glu 
1               5                   10                  15      


Ser Phe Asp Val Pro Glu Glu His Arg Leu Ser Asn Ile Asn 
            20                  25                  30  


<210> 33
<211> 30
<212> PRT
<213> Danio rerio

<400> 33
Leu Pro Glu Ile Glu Lys Phe Phe Pro Tyr Asn Pro Ser Glu Phe Glu 
1               5                   10                  15      


Cys Tyr Ser Val Pro Asp Glu Val Tyr Leu Ser Arg Phe Ser 
            20                  25                  30  


<210> 34
<211> 28
<212> PRT
<213> Caenorhabditis elegans

<400> 34
Ala Ala Asp Ile Glu Asp Asp Met Leu Asn Leu Glu Asp Gln Asp Val 
1               5                   10                  15      


Val Leu Ser Glu Asp Arg Pro Tyr Gly Asp Val Ile 
            20                  25              


<210> 35
<211> 27
<212> PRT
<213> Saccharomyces cerevisiae

<400> 35
Asp Tyr Asp Ile Glu Ile Ala Pro Gln Arg Gln Glu Pro Leu Pro Tyr 
1               5                   10                  15      


Val Pro Glu Gly Tyr Ser Pro Phe Gln Gln Asp 
            20                  25          


<210> 36
<211> 31
<212> PRT
<213> Chaetomium thermophilum

<400> 36
Val Glu Glu Val Glu Tyr Ala Pro Pro Lys Pro Lys Glu Met Pro Tyr 
1               5                   10                  15      


Glu Ser Asp Val Phe Pro Glu Gly Val Leu Thr Tyr Glu Gly Leu 
            20                  25                  30      


<210> 37
<211> 30
<212> PRT
<213> Schizosaccharomyces pombe

<400> 37
Glu Glu Asp Ile Glu Tyr Met Pro Pro Pro Val His Leu Asp Pro Ile 
1               5                   10                  15      


Gln Ser Leu Gly Phe Asp Asp Val Ala Ile Asp Cys Glu Thr 
            20                  25                  30  


