                         SEQUENCE LISTING

<110>  Pfizer Inc.
       BALDUS, Phoebe A.
       BEIDLER, David R.
       BINKS, Michael
       DEMARCO, Suzanne
       HUANG, Rong
       MCDONNELL MOOREHEAD, Tara
       NEELAKANTAN, Srividya
       HEUBERT, Hendrik
       RUNNELS, Herbert
       SANKAR, Savita
       SHAPKINA, Tatiana G.
       SHERLOCK, Sarah P.
       WHITELEY, Laurence O.
       YONG, Florence H. L.
 
<120>  Methods of Treating Duchenne Muscular Dystrophy Using AAV 
       Mini-dystrophin Gene Therapy

<130>  PC72528A

<150>  62/867,862
<151>  2019-06-27

<150>  63/016,230
<151>  2020-04-27

<150>  63/025,141
<151>  2020-05-14

<160>  244   

<170>  PatentIn version 3.5

<210>  1
<211>  3978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hopti-Dys3978 gene

<400>  1
atgctttggt gggaggaagt ggaggactgc tacgagagag aggacgtgca gaagaaaacc       60

ttcaccaagt gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggatgg caggagactg ctggacctgc tggagggcct gaccggccag      180

aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtg      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat caacttcacc      480

acctcctgga gcgacggcct ggccctgaac gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtggt gtgtcagcag agcgccaccc agagactgga gcacgccttc      600

aacatcgcca gataccagct gggcatcgag aagctgctgg accccgagga cgtggacacc      660

acctaccccg acaagaaaag catcctcatg tacattacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccaggcc ccccaaagtg      780

accaaggagg agcacttcca gctgcaccac cagatgcact acagccagca gatcacagtg      840

agcctggccc agggctatga gagaaccagc agccccaagc ccagattcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccacctcc gaccccacca gaagcccctt ccccagccag      960

cacctggagg cccccgagga caagagcttc ggcagcagcc tgatggagag cgaagtgaac     1020

ctggacagat accagaccgc cctggaggaa gtgctgtcct ggctgctgag cgccgaggac     1080

accctgcagg cccagggcga gatcagcaac gacgtggaag tggtgaagga ccagttccac     1140

acccacgagg gctacatgat ggatctgacc gcccaccagg gcagagtggg caatatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgagga gaccgaagtg     1260

caggagcaga tgaacctgct gaacagcaga tgggagtgcc tgagagtggc cagcatggag     1320

aagcagagca acctgcacag agtgctgatg gacctgcaga accagaagct gaaggagctg     1380

aacgactggc tgaccaagac cgaggagcgg accagaaaga tggaggagga gcccctgggc     1440

cccgacctgg aggacctgaa gagacaggtg cagcagcaca aagtgctgca ggaggacctg     1500

gagcaggagc aggtgcgcgt gaacagcctg acccacatgg tggtggtcgt ggacgagagc     1560

agcggcgacc acgccacagc cgccctggaa gagcagctga aagtgctggg cgacagatgg     1620

gccaatattt gtaggtggac cgaggacaga tgggtgctgc tgcaggacca gcccgacctg     1680

gcccctggcc tgaccaccat cggcgccagc cccacccaga ccgtgaccct ggtgacccag     1740

cccgtggtga caaaggagac cgccatcagc aagctggaga tgcccagctc cctgatgctg     1800

gaagtgccca cccaccgcct gctccagcag ttccccctgg acctggagaa gttcctggcc     1860

tggctgaccg aggccgaaac caccgccaat gtgctccagg acgccactag aaaggagagg     1920

ctgctggagg acagcaaggg cgtgaaagag ctgatgaagc agtggcagga tctgcagggc     1980

gaaatcgagg cccacaccga cgtgtaccac aacctggacg agaacagcca gaagattctg     2040

aggagcctgg agggcagcga cgacgccgtc ctgctccaga ggaggctgga caacatgaac     2100

ttcaagtgga gcgagctgcg gaagaagagc ctgaacatcc ggagccacct ggaagccagc     2160

agcgaccagt ggaagagact gcacctgagc ctgcaggagc tgctggtgtg gctgcagctg     2220

aaggacgacg agctgagcag acaggccccc atcggcggcg acttccccgc cgtgcagaag     2280

cagaacgacg tgcaccgggc cttcaagagg gagctgaaaa ccaaggaacc cgtgatcatg     2340

agcaccctgg agacagtgcg gatcttcctg accgagcagc ccctggaggg actggagaag     2400

ctgtaccagg agcccagaga gctgcccccc gaggagagag cccagaacgt gaccaggctg     2460

ctgagaaagc aggccgagga agtgaatacc gagtgggaga agctgaatct gcacagcgcc     2520

gactggcaga gaaagatcga cgagaccctg gagagactcc aggaactgca ggaagccacc     2580

gacgagctgg acctgaagct gagacaggcc gaagtgatca agggcagctg gcagcctgtg     2640

ggcgatctgc tgatcgactc cctgcaggat cacctggaga aagtgaaggc cctgcggggc     2700

gagatcgccc ccctgaagga gaatgtgagc cacgtgaacg acctggccag acagctgacc     2760

accctgggca tccagctgag cccctacaac ctgagcacac tggaggatct gaacacccgg     2820

tggaaactgc tgcaggtggc cgtggaggat agagtgaggc agctgcacga agcccacaga     2880

gacttcggcc ctgcctccca gcacttcctg agcaccagcg tgcagggccc ctgggagaga     2940

gccatctccc ccaacaaagt gccctactac atcaaccacg agacccagac cacctgctgg     3000

gaccacccta agatgaccga gctgtatcag agcctggccg acctgaacaa tgtgcggttc     3060

agcgcctaca gaaccgccat gaagctgcgg agactgcaga aggccctgtg cctggatctg     3120

ctgagcctga gcgccgcctg cgacgccctg gaccagcaca acctgaagca gaatgaccag     3180

cccatggaca tcctgcagat catcaactgc ctgaccacaa tctacgaccg gctggaacag     3240

gagcacaaca acctggtgaa tgtgcccctg tgcgtggaca tgtgcctgaa ttggctgctg     3300

aacgtgtacg acaccggcag gaccggcaga atccgcgtgc tgagcttcaa gaccggcatc     3360

atcagcctgt gcaaggccca cctggaggat aagtaccgct acctgttcaa gcaggtggcc     3420

agcagcaccg gcttctgcga tcagaggaga ctgggcctgc tgctgcacga tagcatccag     3480

atccctaggc agctgggcga agtggccagc tttggcggca gcaacatcga gccctctgtg     3540

aggagctgct tccagttcgc caacaacaag cccgagatcg aggccgccct gttcctggac     3600

tggatgaggc tggagcctca gagcatggtg tggctgcctg tgctgcacag agtggccgcc     3660

gccgagaccg ccaagcacca ggccaagtgc aatatctgca aggagtgccc catcatcggc     3720

ttccggtaca ggagcctgaa gcacttcaac tacgacatct gccagagctg ctttttcagc     3780

ggcagagtgg ccaagggcca caaaatgcac taccccatgg tggagtactg cacccccacc     3840

acctccggcg aggatgtgag agacttcgcc aaagtgctga agaataagtt ccggaccaag     3900

cggtactttg ccaagcaccc caggatgggc tacctgcccg tgcagaccgt gctggaaggc     3960

gacaacatgg agacctga                                                   3978


<210>  2
<211>  3837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hopti-Dys3837 gene

<400>  2
atgctttggt gggaggaagt ggaggactgc tacgagagag aggacgtgca gaagaaaacc       60

ttcaccaagt gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggatgg caggagactg ctggacctgc tggagggcct gaccggccag      180

aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtg      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat caacttcacc      480

acctcctgga gcgacggcct ggccctgaac gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtggt gtgtcagcag agcgccaccc agagactgga gcacgccttc      600

aacatcgcca gataccagct gggcatcgag aagctgctgg accccgagga cgtggacacc      660

acctaccccg acaagaaaag catcctcatg tacattacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccaggcc ccccaaagtg      780

accaaggagg agcacttcca gctgcaccac cagatgcact acagccagca gatcacagtg      840

agcctggccc agggctatga gagaaccagc agccccaagc ccagattcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccacctcc gaccccacca gaagcccctt ccccagccag      960

cacctggagg cccccgagga caagagcttc ggcagcagcc tgatggagag cgaagtgaac     1020

ctggacagat accagaccgc cctggaggaa gtgctgtcct ggctgctgag cgccgaggac     1080

accctgcagg cccagggcga gatcagcaac gacgtggaag tggtgaagga ccagttccac     1140

acccacgagg gctacatgat ggatctgacc gcccaccagg gcagagtggg caatatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgagga gaccgaagtg     1260

caggagcaga tgaacctgct gaacagcaga tgggagtgcc tgagagtggc cagcatggag     1320

aagcagagca acctgcacag agtgctgatg gacctgcaga accagaagct gaaggagctg     1380

aacgactggc tgaccaagac cgaggagcgg accagaaaga tggaggagga gcccctgggc     1440

cccgacctgg aggacctgaa gagacaggtg cagcagcaca aagtgctgca ggaggacctg     1500

gagcaggagc aggtgcgcgt gaacagcctg acccacatgg tggtggtcgt ggacgagagc     1560

agcggcgacc acgccacagc cgccctggaa gagcagctga aagtgctggg cgacagatgg     1620

gccaatattt gtaggtggac cgaggacaga tgggtgctgc tgcaggacac ccaccgcctg     1680

ctccagcagt tccccctgga cctggagaag ttcctggcct ggctgaccga ggccgaaacc     1740

accgccaatg tgctccagga cgccactaga aaggagaggc tgctggagga cagcaagggc     1800

gtgaaagagc tgatgaagca gtggcaggat ctgcagggcg aaatcgaggc ccacaccgac     1860

gtgtaccaca acctggacga gaacagccag aagattctga ggagcctgga gggcagcgac     1920

gacgccgtcc tgctccagag gaggctggac aacatgaact tcaagtggag cgagctgcgg     1980

aagaagagcc tgaacatccg gagccacctg gaagccagca gcgaccagtg gaagagactg     2040

cacctgagcc tgcaggagct gctggtgtgg ctgcagctga aggacgacga gctgagcaga     2100

caggccccca tcggcggcga cttccccgcc gtgcagaagc agaacgacgt gcaccgggcc     2160

ttcaagaggg agctgaaaac caaggaaccc gtgatcatga gcaccctgga gacagtgcgg     2220

atcttcctga ccgagcagcc cctggaggga ctggagaagc tgtaccagga gcccagagag     2280

ctgccccccg aggagagagc ccagaacgtg accaggctgc tgagaaagca ggccgaggaa     2340

gtgaataccg agtgggagaa gctgaatctg cacagcgccg actggcagag aaagatcgac     2400

gagaccctgg agagactcca ggaactgcag gaagccaccg acgagctgga cctgaagctg     2460

agacaggccg aagtgatcaa gggcagctgg cagcctgtgg gcgatctgct gatcgactcc     2520

ctgcaggatc acctggagaa agtgaaggcc ctgcggggcg agatcgcccc cctgaaggag     2580

aatgtgagcc acgtgaacga cctggccaga cagctgacca ccctgggcat ccagctgagc     2640

ccctacaacc tgagcacact ggaggatctg aacacccggt ggaaactgct gcaggtggcc     2700

gtggaggata gagtgaggca gctgcacgaa gcccacagag acttcggccc tgcctcccag     2760

cacttcctga gcaccagcgt gcagggcccc tgggagagag ccatctcccc caacaaagtg     2820

ccctactaca tcaaccacga gacccagacc acctgctggg accaccctaa gatgaccgag     2880

ctgtatcaga gcctggccga cctgaacaat gtgcggttca gcgcctacag aaccgccatg     2940

aagctgcgga gactgcagaa ggccctgtgc ctggatctgc tgagcctgag cgccgcctgc     3000

gacgccctgg accagcacaa cctgaagcag aatgaccagc ccatggacat cctgcagatc     3060

atcaactgcc tgaccacaat ctacgaccgg ctggaacagg agcacaacaa cctggtgaat     3120

gtgcccctgt gcgtggacat gtgcctgaat tggctgctga acgtgtacga caccggcagg     3180

accggcagaa tccgcgtgct gagcttcaag accggcatca tcagcctgtg caaggcccac     3240

ctggaggata agtaccgcta cctgttcaag caggtggcca gcagcaccgg cttctgcgat     3300

cagaggagac tgggcctgct gctgcacgat agcatccaga tccctaggca gctgggcgaa     3360

gtggccagct ttggcggcag caacatcgag ccctctgtga ggagctgctt ccagttcgcc     3420

aacaacaagc ccgagatcga ggccgccctg ttcctggact ggatgaggct ggagcctcag     3480

agcatggtgt ggctgcctgt gctgcacaga gtggccgccg ccgagaccgc caagcaccag     3540

gccaagtgca atatctgcaa ggagtgcccc atcatcggct tccggtacag gagcctgaag     3600

cacttcaact acgacatctg ccagagctgc tttttcagcg gcagagtggc caagggccac     3660

aaaatgcact accccatggt ggagtactgc acccccacca cctccggcga ggatgtgaga     3720

gacttcgcca aagtgctgaa gaataagttc cggaccaagc ggtactttgc caagcacccc     3780

aggatgggct acctgcccgt gcagaccgtg ctggaaggcg acaacatgga gacctga        3837


<210>  3
<211>  3978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Copti-Dys3978 gene

<400>  3
atgctttggt gggaggaagt ggaggactgc tacgagcggg aggacgtgca gaagaaaacc       60

ttcaccaagt gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg caggcggctg ctggacctcc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccagg gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgtcctggg tgcggcagag caccaggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccacag gcccgacctg      540

ttcgactgga acagcgtggt gtgccagcag agcgccaccc agaggctgga acacgccttc      600

aacatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaaag catcctcatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggagatgc tgcccaggcc ccccaaggtc      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

agcctggccc agggctacga gaggaccagc agccccaagc ccaggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccacctcc gaccccacca ggtccccctt ccccagccag      960

catctcgaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaggtgaac     1020

ctggacagat accagaccgc cctggaagaa gtgctgtctt ggctgctgtc cgccgaggac     1080

accctgcagg cccagggcga gatcagcaac gacgtggagg tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgtccg aggacgagga aaccgaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgagggtggc cagcatggaa     1320

aagcagagca acctgcacag ggtgctgatg gatctgcaga accagaagct caaagagctg     1380

aacgactggc tgaccaagac cgaggaaagg acccggaaga tggaagagga acccctgggc     1440

cccgatctcg aagatctgaa gaggcaggtg cagcagcaca aggtgctgca ggaagatctc     1500

gaacaggaac aggtccgggt caacagcctg acccacatgg tcgtggtggt ggacgagagc     1560

agcggcgacc acgccaccgc tgccctggaa gagcagctga aggtgctggg cgacagatgg     1620

gccaacatct gccggtggac cgaggacaga tgggtcctcc tgcaggacca gcccgacctg     1680

gcccctggcc tgacaaccat cggcgccagc cccacccaga ccgtgaccct ggtgacccag     1740

cccgtggtga ccaaagagac cgccatcagc aagctggaaa tgcccagctc cctgatgctg     1800

gaagtgccca cccacaggct cctccagcag ttccccctgg acctggaaaa gttcctggcc     1860

tggctgaccg aggccgagac caccgccaac gtgctgcagg acgccaccag gaaagagagg     1920

ctgctggaag atagcaaggg cgtgaaagag ctgatgaagc agtggcagga cctgcagggg     1980

gagattgagg cccacaccga cgtgtaccac aacctggacg agaacagcca gaaaatcctg     2040

agaagcctgg aaggcagcga cgacgccgtg ctgctgcaga ggcggctgga caacatgaac     2100

ttcaagtgga gcgagctgag gaagaagagc ctgaacatca ggtcccatct ggaagccagc     2160

agcgaccagt ggaagaggct gcacctgagc ctgcaggaac tgctcgtctg gctgcagctg     2220

aaagacgacg agctgtccag gcaggccccc atcggcggcg acttccccgc cgtgcagaaa     2280

cagaacgacg tgcacagggc cttcaagcgg gagctgaaaa ccaaagagcc cgtgatcatg     2340

agcaccctgg aaaccgtgag gatcttcctg accgagcagc ccctggaagg actggaaaag     2400

ctgtaccagg aacccagaga gctgcccccc gaggaacggg cccagaacgt gaccaggctg     2460

ctgagaaagc aggccgagga agtgaacacc gagtgggaga agctgaacct gcactccgcc     2520

gactggcaga ggaagatcga cgagaccctg gaaaggctcc aggaactgca ggaagccacc     2580

gacgagctgg acctgaagct gagacaggcc gaggtgatca agggcagctg gcagcccgtg     2640

ggcgacctgc tgatcgactc cctgcaggat cacctggaaa aagtgaaggc cctgcggggc     2700

gagatcgccc ccctgaaaga gaacgtcagc cacgtcaacg acctggccag gcagctgacc     2760

accctgggca tccagctgtc cccctacaac ctgtccaccc tggaagatct gaacacaagg     2820

tggaagctgc tgcaggtggc cgtggaggac agagtgaggc agctgcacga ggcccacagg     2880

gacttcggcc ctgcctccca gcacttcctg agcaccagcg tgcagggccc ctgggagagg     2940

gccatctccc ccaacaaggt gccctactac atcaaccacg agacccagac cacctgctgg     3000

gaccacccta agatgaccga gctgtaccag tccctggccg acctgaacaa tgtgcggttc     3060

agcgcctacc ggaccgccat gaagctgagg cggctgcaga aagccctgtg cctggatctg     3120

ctgtccctga gcgccgcctg cgacgccctg gaccagcaca acctgaagca gaacgaccag     3180

cccatggata tcctgcagat catcaactgt ctgaccacca tctacgacag gctggaacag     3240

gaacacaaca acctggtcaa cgtgcccctg tgcgtggaca tgtgcctgaa ctggctgctg     3300

aacgtgtacg acaccggcag gaccggccgg atcagggtgc tgtccttcaa gaccggcatc     3360

atcagcctgt gcaaggccca cctggaagat aagtaccgct acctgttcaa gcaggtggcc     3420

agctctaccg gcttctgcga ccagcggagg ctgggcctgc tgctgcacga cagcatccag     3480

atcccccggc agctgggcga ggtggcctcc ttcggcggca gcaacatcga gcccagcgtg     3540

cggagctgct tccagttcgc caacaacaag cccgagatcg aggccgccct gttcctggac     3600

tggatgcggc tggaacccca gagcatggtc tggctgcccg tgctgcacag agtggctgcc     3660

gccgagaccg ccaagcacca ggccaagtgc aacatctgca aagagtgccc catcatcggc     3720

ttcaggtaca gaagcctgaa gcacttcaac tacgacatct gccagagctg tttcttcagc     3780

ggcagggtgg ccaagggcca caaaatgcac taccccatgg tggagtactg cacccccacc     3840

acctccggcg aggacgtgag ggacttcgcc aaggtgctga agaataagtt ccggaccaag     3900

cggtacttcg ccaaacaccc caggatgggc tacctgcccg tgcagaccgt gctggaaggc     3960

gacaacatgg aaacctga                                                   3978


<210>  4
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCK promoter

<400>  4
gaattcggta ccccactacg ggtttaggct gcccatgtaa ggaggcaagg cctggggaca       60

cccgagatgc ctggttataa ttaacccaga catgtggctg cccccccccc ccccaacacc      120

tgctgcctct aaaaataacc ctgtccctgg tggatcccct gcatgcgaag atcttcgaac      180

aaggctgtgg gggactgagg gcaggctgta acaggcttgg gggccagggc ttatacgtgc      240

ctgggactcc caaagtatta ctgttccatg ttcccggcga agggccagct gtcccccgcc      300

agctagactc agcacttagt ttaggaacca gtgagcaagt cagcccttgg ggcagcccat      360

acaaggccat ggggctgggc aagctgcacg cctgggtccg gggtgggcac ggtgcccggg      420

caacgagctg aaagctcatc tgctctcagg ggcccctccc tggggacagc ccctcctggc      480

tagtcacacc ctgtaggctc ctctatataa cccaggggca caggggctgc cctcattcta      540

ccaccacctc cacagcacag acagacactc aggagccagc cagcgtcgag cggccgatcc      600

gccacc                                                                 606


<210>  5
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCKplus promoter

<400>  5
gaattcggta ccccactacg ggtctaggct gcccatgtaa ggaggcaagg cctggggaca       60

cccgagatgc ctggttataa ttaaccccaa cacctgctgc cccccccccc ccaacacctg      120

ctgcctctaa aaataaccct gtccctggtg gatcccctgc atgccccact acgggtttag      180

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      240

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      300

tggtggatcc cctgcatgcg aagatcttcg aacaaggctg tgggggactg agggcaggct      360

gtaacaggct tgggggccag ggcttatacg tgcctgggac tcccaaagta ttactgttcc      420

atgttcccgg cgaagggcca gctgtccccc gccagctaga ctcagcactt agtttaggaa      480

ccagtgagca agtcagccct tggggcagcc catacaaggc catggggctg ggcaagctgc      540

acgcctgggt ccggggtggg cacggtgccc gggcaacgag ctgaaagctc atctgctctc      600

aggggcccct ccctggggac agcccctcct ggctagtcac accctgtagg ctcctctata      660

taacccaggg gcacaggggc tgccctcatt ctaccaccac ctccacagca cagacagaca      720

ctcaggagcc agccagcgtc gagcggccga tccgccacc                             759


<210>  6
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polyA

<400>  6
tgaggagctc gagaggccta ataaagagct cagatgcatc gatcagagtg tgttggtttt       60

ttgtgtg                                                                 67


<210>  7
<211>  1325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dys3978 protein

<400>  7

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Gln Pro Asp Leu 
545                 550                 555                 560 


Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr 
                565                 570                 575     


Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 
            580                 585                 590         


Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr His Arg Leu Leu 
        595                 600                 605             


Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu 
    610                 615                 620                 


Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg 
625                 630                 635                 640 


Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln 
                645                 650                 655     


Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu 
            660                 665                 670         


Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp 
        675                 680                 685             


Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser 
    690                 695                 700                 


Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser 
705                 710                 715                 720 


Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 
                725                 730                 735     


Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly 
            740                 745                 750         


Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe 
        755                 760                 765             


Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu 
    770                 775                 780                 


Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
785                 790                 795                 800 


Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 
                805                 810                 815     


Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp 
            820                 825                 830         


Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu 
        835                 840                 845             


Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 
    850                 855                 860                 


Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val 
865                 870                 875                 880 


Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 
                885                 890                 895     


Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 
            900                 905                 910         


Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 
        915                 920                 925             


Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 
    930                 935                 940                 


Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg 
945                 950                 955                 960 


Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
                965                 970                 975     


Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn 
            980                 985                 990         


His Glu Thr Gln Thr Thr Cys Trp  Asp His Pro Lys Met  Thr Glu Leu 
        995                 1000                 1005             


Tyr Gln  Ser Leu Ala Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr 
    1010                 1015                 1020             


Arg Thr  Ala Met Lys Leu Arg  Arg Leu Gln Lys Ala  Leu Cys Leu 
    1025                 1030                 1035             


Asp Leu  Leu Ser Leu Ser Ala  Ala Cys Asp Ala Leu  Asp Gln His 
    1040                 1045                 1050             


Asn Leu  Lys Gln Asn Asp Gln  Pro Met Asp Ile Leu  Gln Ile Ile 
    1055                 1060                 1065             


Asn Cys  Leu Thr Thr Ile Tyr  Asp Arg Leu Glu Gln  Glu His Asn 
    1070                 1075                 1080             


Asn Leu  Val Asn Val Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp 
    1085                 1090                 1095             


Leu Leu  Asn Val Tyr Asp Thr  Gly Arg Thr Gly Arg  Ile Arg Val 
    1100                 1105                 1110             


Leu Ser  Phe Lys Thr Gly Ile  Ile Ser Leu Cys Lys  Ala His Leu 
    1115                 1120                 1125             


Glu Asp  Lys Tyr Arg Tyr Leu  Phe Lys Gln Val Ala  Ser Ser Thr 
    1130                 1135                 1140             


Gly Phe  Cys Asp Gln Arg Arg  Leu Gly Leu Leu Leu  His Asp Ser 
    1145                 1150                 1155             


Ile Gln  Ile Pro Arg Gln Leu  Gly Glu Val Ala Ser  Phe Gly Gly 
    1160                 1165                 1170             


Ser Asn  Ile Glu Pro Ser Val  Arg Ser Cys Phe Gln  Phe Ala Asn 
    1175                 1180                 1185             


Asn Lys  Pro Glu Ile Glu Ala  Ala Leu Phe Leu Asp  Trp Met Arg 
    1190                 1195                 1200             


Leu Glu  Pro Gln Ser Met Val  Trp Leu Pro Val Leu  His Arg Val 
    1205                 1210                 1215             


Ala Ala  Ala Glu Thr Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys 
    1220                 1225                 1230             


Lys Glu  Cys Pro Ile Ile Gly  Phe Arg Tyr Arg Ser  Leu Lys His 
    1235                 1240                 1245             


Phe Asn  Tyr Asp Ile Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Val 
    1250                 1255                 1260             


Ala Lys  Gly His Lys Met His  Tyr Pro Met Val Glu  Tyr Cys Thr 
    1265                 1270                 1275             


Pro Thr  Thr Ser Gly Glu Asp  Val Arg Asp Phe Ala  Lys Val Leu 
    1280                 1285                 1290             


Lys Asn  Lys Phe Arg Thr Lys  Arg Tyr Phe Ala Lys  His Pro Arg 
    1295                 1300                 1305             


Met Gly  Tyr Leu Pro Val Gln  Thr Val Leu Glu Gly  Asp Asn Met 
    1310                 1315                 1320             


Glu Thr  
    1325 


<210>  8
<211>  1278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dys3837 protein

<400>  8

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Thr His Arg Leu 
545                 550                 555                 560 


Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr 
                565                 570                 575     


Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu 
            580                 585                 590         


Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp 
        595                 600                 605             


Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn 
    610                 615                 620                 


Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp 
625                 630                 635                 640 


Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp 
                645                 650                 655     


Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala 
            660                 665                 670         


Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu 
        675                 680                 685             


Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile 
    690                 695                 700                 


Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala 
705                 710                 715                 720 


Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu 
                725                 730                 735     


Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu 
            740                 745                 750         


Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 
        755                 760                 765             


Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu 
    770                 775                 780                 


Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp 
785                 790                 795                 800 


Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu 
                805                 810                 815     


Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro 
            820                 825                 830         


Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val 
        835                 840                 845             


Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His 
    850                 855                 860                 


Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser 
865                 870                 875                 880 


Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu 
                885                 890                 895     


Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His 
            900                 905                 910         


Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln 
        915                 920                 925             


Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile 
    930                 935                 940                 


Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu 
945                 950                 955                 960 


Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr 
                965                 970                 975     


Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp 
            980                 985                 990         


Leu Leu Ser Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
        995                 1000                 1005             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    1010                 1015                 1020             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    1025                 1030                 1035             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    1040                 1045                 1050             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    1055                 1060                 1065             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    1070                 1075                 1080             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    1085                 1090                 1095             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    1100                 1105                 1110             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    1115                 1120                 1125             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    1130                 1135                 1140             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    1145                 1150                 1155             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    1160                 1165                 1170             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    1175                 1180                 1185             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    1190                 1195                 1200             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    1205                 1210                 1215             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    1220                 1225                 1230             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    1235                 1240                 1245             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    1250                 1255                 1260             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    1265                 1270                 1275             


<210>  9
<211>  4953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector genome with Hopti-Dys3978 gene

<400>  9
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcggt accccactac gggtttaggc      180

tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata attaacccag      240

acatgtggct gccccccccc cccccaacac ctgctgcctc taaaaataac cctgtccctg      300

gtggatcccc tgcatgcgaa gatcttcgaa caaggctgtg ggggactgag ggcaggctgt      360

aacaggcttg ggggccaggg cttatacgtg cctgggactc ccaaagtatt actgttccat      420

gttcccggcg aagggccagc tgtcccccgc cagctagact cagcacttag tttaggaacc      480

agtgagcaag tcagcccttg gggcagccca tacaaggcca tggggctggg caagctgcac      540

gcctgggtcc ggggtgggca cggtgcccgg gcaacgagct gaaagctcat ctgctctcag      600

gggcccctcc ctggggacag cccctcctgg ctagtcacac cctgtaggct cctctatata      660

acccaggggc acaggggctg ccctcattct accaccacct ccacagcaca gacagacact      720

caggagccag ccagcgtcga gcggccgatc cgccaccatg ctttggtggg aggaagtgga      780

ggactgctac gagagagagg acgtgcagaa gaaaaccttc accaagtggg tgaacgccca      840

gttcagcaag ttcggcaagc agcacatcga gaacctgttc agcgacctgc aggatggcag      900

gagactgctg gacctgctgg agggcctgac cggccagaag ctgcccaagg agaagggcag      960

caccagagtg cacgccctga acaacgtgaa caaggccctg agagtgctgc agaacaacaa     1020

cgtggacctg gtgaacatcg gcagcaccga catcgtggac ggcaaccaca agctgaccct     1080

gggcctgatc tggaacatca tcctgcactg gcaggtgaag aacgtgatga agaacatcat     1140

ggccggcctg cagcagacca acagcgagaa gatcctgctg agctgggtga ggcagagcac     1200

cagaaactac ccccaggtga acgtgatcaa cttcaccacc tcctggagcg acggcctggc     1260

cctgaacgcc ctgatccaca gccacagacc cgacctgttc gactggaaca gcgtggtgtg     1320

tcagcagagc gccacccaga gactggagca cgccttcaac atcgccagat accagctggg     1380

catcgagaag ctgctggacc ccgaggacgt ggacaccacc taccccgaca agaaaagcat     1440

cctcatgtac attaccagcc tgttccaggt gctgccccag caggtgtcca tcgaggccat     1500

ccaggaagtg gaaatgctgc ccaggccccc caaagtgacc aaggaggagc acttccagct     1560

gcaccaccag atgcactaca gccagcagat cacagtgagc ctggcccagg gctatgagag     1620

aaccagcagc cccaagccca gattcaagag ctacgcctac acccaggccg cctacgtgac     1680

cacctccgac cccaccagaa gccccttccc cagccagcac ctggaggccc ccgaggacaa     1740

gagcttcggc agcagcctga tggagagcga agtgaacctg gacagatacc agaccgccct     1800

ggaggaagtg ctgtcctggc tgctgagcgc cgaggacacc ctgcaggccc agggcgagat     1860

cagcaacgac gtggaagtgg tgaaggacca gttccacacc cacgagggct acatgatgga     1920

tctgaccgcc caccagggca gagtgggcaa tatcctgcag ctgggcagca agctgatcgg     1980

caccggcaag ctgagcgagg acgaggagac cgaagtgcag gagcagatga acctgctgaa     2040

cagcagatgg gagtgcctga gagtggccag catggagaag cagagcaacc tgcacagagt     2100

gctgatggac ctgcagaacc agaagctgaa ggagctgaac gactggctga ccaagaccga     2160

ggagcggacc agaaagatgg aggaggagcc cctgggcccc gacctggagg acctgaagag     2220

acaggtgcag cagcacaaag tgctgcagga ggacctggag caggagcagg tgcgcgtgaa     2280

cagcctgacc cacatggtgg tggtcgtgga cgagagcagc ggcgaccacg ccacagccgc     2340

cctggaagag cagctgaaag tgctgggcga cagatgggcc aatatttgta ggtggaccga     2400

ggacagatgg gtgctgctgc aggaccagcc cgacctggcc cctggcctga ccaccatcgg     2460

cgccagcccc acccagaccg tgaccctggt gacccagccc gtggtgacaa aggagaccgc     2520

catcagcaag ctggagatgc ccagctccct gatgctggaa gtgcccaccc accgcctgct     2580

ccagcagttc cccctggacc tggagaagtt cctggcctgg ctgaccgagg ccgaaaccac     2640

cgccaatgtg ctccaggacg ccactagaaa ggagaggctg ctggaggaca gcaagggcgt     2700

gaaagagctg atgaagcagt ggcaggatct gcagggcgaa atcgaggccc acaccgacgt     2760

gtaccacaac ctggacgaga acagccagaa gattctgagg agcctggagg gcagcgacga     2820

cgccgtcctg ctccagagga ggctggacaa catgaacttc aagtggagcg agctgcggaa     2880

gaagagcctg aacatccgga gccacctgga agccagcagc gaccagtgga agagactgca     2940

cctgagcctg caggagctgc tggtgtggct gcagctgaag gacgacgagc tgagcagaca     3000

ggcccccatc ggcggcgact tccccgccgt gcagaagcag aacgacgtgc accgggcctt     3060

caagagggag ctgaaaacca aggaacccgt gatcatgagc accctggaga cagtgcggat     3120

cttcctgacc gagcagcccc tggagggact ggagaagctg taccaggagc ccagagagct     3180

gccccccgag gagagagccc agaacgtgac caggctgctg agaaagcagg ccgaggaagt     3240

gaataccgag tgggagaagc tgaatctgca cagcgccgac tggcagagaa agatcgacga     3300

gaccctggag agactccagg aactgcagga agccaccgac gagctggacc tgaagctgag     3360

acaggccgaa gtgatcaagg gcagctggca gcctgtgggc gatctgctga tcgactccct     3420

gcaggatcac ctggagaaag tgaaggccct gcggggcgag atcgcccccc tgaaggagaa     3480

tgtgagccac gtgaacgacc tggccagaca gctgaccacc ctgggcatcc agctgagccc     3540

ctacaacctg agcacactgg aggatctgaa cacccggtgg aaactgctgc aggtggccgt     3600

ggaggataga gtgaggcagc tgcacgaagc ccacagagac ttcggccctg cctcccagca     3660

cttcctgagc accagcgtgc agggcccctg ggagagagcc atctccccca acaaagtgcc     3720

ctactacatc aaccacgaga cccagaccac ctgctgggac caccctaaga tgaccgagct     3780

gtatcagagc ctggccgacc tgaacaatgt gcggttcagc gcctacagaa ccgccatgaa     3840

gctgcggaga ctgcagaagg ccctgtgcct ggatctgctg agcctgagcg ccgcctgcga     3900

cgccctggac cagcacaacc tgaagcagaa tgaccagccc atggacatcc tgcagatcat     3960

caactgcctg accacaatct acgaccggct ggaacaggag cacaacaacc tggtgaatgt     4020

gcccctgtgc gtggacatgt gcctgaattg gctgctgaac gtgtacgaca ccggcaggac     4080

cggcagaatc cgcgtgctga gcttcaagac cggcatcatc agcctgtgca aggcccacct     4140

ggaggataag taccgctacc tgttcaagca ggtggccagc agcaccggct tctgcgatca     4200

gaggagactg ggcctgctgc tgcacgatag catccagatc cctaggcagc tgggcgaagt     4260

ggccagcttt ggcggcagca acatcgagcc ctctgtgagg agctgcttcc agttcgccaa     4320

caacaagccc gagatcgagg ccgccctgtt cctggactgg atgaggctgg agcctcagag     4380

catggtgtgg ctgcctgtgc tgcacagagt ggccgccgcc gagaccgcca agcaccaggc     4440

caagtgcaat atctgcaagg agtgccccat catcggcttc cggtacagga gcctgaagca     4500

cttcaactac gacatctgcc agagctgctt tttcagcggc agagtggcca agggccacaa     4560

aatgcactac cccatggtgg agtactgcac ccccaccacc tccggcgagg atgtgagaga     4620

cttcgccaaa gtgctgaaga ataagttccg gaccaagcgg tactttgcca agcaccccag     4680

gatgggctac ctgcccgtgc agaccgtgct ggaaggcgac aacatggaga cctgatgagg     4740

agctcgagag gcctaataaa gagctcagat gcatcgatca gagtgtgttg gttttttgtg     4800

tgagatctag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     4860

cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt     4920

gagcgagcga gcgcgcagag agggagtggc caa                                  4953


<210>  10
<211>  4812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector genome with Hopti-Dys3837 gene

<400>  10
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcggt accccactac gggtttaggc      180

tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata attaacccag      240

acatgtggct gccccccccc cccccaacac ctgctgcctc taaaaataac cctgtccctg      300

gtggatcccc tgcatgcgaa gatcttcgaa caaggctgtg ggggactgag ggcaggctgt      360

aacaggcttg ggggccaggg cttatacgtg cctgggactc ccaaagtatt actgttccat      420

gttcccggcg aagggccagc tgtcccccgc cagctagact cagcacttag tttaggaacc      480

agtgagcaag tcagcccttg gggcagccca tacaaggcca tggggctggg caagctgcac      540

gcctgggtcc ggggtgggca cggtgcccgg gcaacgagct gaaagctcat ctgctctcag      600

gggcccctcc ctggggacag cccctcctgg ctagtcacac cctgtaggct cctctatata      660

acccaggggc acaggggctg ccctcattct accaccacct ccacagcaca gacagacact      720

caggagccag ccagcgtcga gcggccgatc cgccaccatg ctttggtggg aggaagtgga      780

ggactgctac gagagagagg acgtgcagaa gaaaaccttc accaagtggg tgaacgccca      840

gttcagcaag ttcggcaagc agcacatcga gaacctgttc agcgacctgc aggatggcag      900

gagactgctg gacctgctgg agggcctgac cggccagaag ctgcccaagg agaagggcag      960

caccagagtg cacgccctga acaacgtgaa caaggccctg agagtgctgc agaacaacaa     1020

cgtggacctg gtgaacatcg gcagcaccga catcgtggac ggcaaccaca agctgaccct     1080

gggcctgatc tggaacatca tcctgcactg gcaggtgaag aacgtgatga agaacatcat     1140

ggccggcctg cagcagacca acagcgagaa gatcctgctg agctgggtga ggcagagcac     1200

cagaaactac ccccaggtga acgtgatcaa cttcaccacc tcctggagcg acggcctggc     1260

cctgaacgcc ctgatccaca gccacagacc cgacctgttc gactggaaca gcgtggtgtg     1320

tcagcagagc gccacccaga gactggagca cgccttcaac atcgccagat accagctggg     1380

catcgagaag ctgctggacc ccgaggacgt ggacaccacc taccccgaca agaaaagcat     1440

cctcatgtac attaccagcc tgttccaggt gctgccccag caggtgtcca tcgaggccat     1500

ccaggaagtg gaaatgctgc ccaggccccc caaagtgacc aaggaggagc acttccagct     1560

gcaccaccag atgcactaca gccagcagat cacagtgagc ctggcccagg gctatgagag     1620

aaccagcagc cccaagccca gattcaagag ctacgcctac acccaggccg cctacgtgac     1680

cacctccgac cccaccagaa gccccttccc cagccagcac ctggaggccc ccgaggacaa     1740

gagcttcggc agcagcctga tggagagcga agtgaacctg gacagatacc agaccgccct     1800

ggaggaagtg ctgtcctggc tgctgagcgc cgaggacacc ctgcaggccc agggcgagat     1860

cagcaacgac gtggaagtgg tgaaggacca gttccacacc cacgagggct acatgatgga     1920

tctgaccgcc caccagggca gagtgggcaa tatcctgcag ctgggcagca agctgatcgg     1980

caccggcaag ctgagcgagg acgaggagac cgaagtgcag gagcagatga acctgctgaa     2040

cagcagatgg gagtgcctga gagtggccag catggagaag cagagcaacc tgcacagagt     2100

gctgatggac ctgcagaacc agaagctgaa ggagctgaac gactggctga ccaagaccga     2160

ggagcggacc agaaagatgg aggaggagcc cctgggcccc gacctggagg acctgaagag     2220

acaggtgcag cagcacaaag tgctgcagga ggacctggag caggagcagg tgcgcgtgaa     2280

cagcctgacc cacatggtgg tggtcgtgga cgagagcagc ggcgaccacg ccacagccgc     2340

cctggaagag cagctgaaag tgctgggcga cagatgggcc aatatttgta ggtggaccga     2400

ggacagatgg gtgctgctgc aggacaccca ccgcctgctc cagcagttcc ccctggacct     2460

ggagaagttc ctggcctggc tgaccgaggc cgaaaccacc gccaatgtgc tccaggacgc     2520

cactagaaag gagaggctgc tggaggacag caagggcgtg aaagagctga tgaagcagtg     2580

gcaggatctg cagggcgaaa tcgaggccca caccgacgtg taccacaacc tggacgagaa     2640

cagccagaag attctgagga gcctggaggg cagcgacgac gccgtcctgc tccagaggag     2700

gctggacaac atgaacttca agtggagcga gctgcggaag aagagcctga acatccggag     2760

ccacctggaa gccagcagcg accagtggaa gagactgcac ctgagcctgc aggagctgct     2820

ggtgtggctg cagctgaagg acgacgagct gagcagacag gcccccatcg gcggcgactt     2880

ccccgccgtg cagaagcaga acgacgtgca ccgggccttc aagagggagc tgaaaaccaa     2940

ggaacccgtg atcatgagca ccctggagac agtgcggatc ttcctgaccg agcagcccct     3000

ggagggactg gagaagctgt accaggagcc cagagagctg ccccccgagg agagagccca     3060

gaacgtgacc aggctgctga gaaagcaggc cgaggaagtg aataccgagt gggagaagct     3120

gaatctgcac agcgccgact ggcagagaaa gatcgacgag accctggaga gactccagga     3180

actgcaggaa gccaccgacg agctggacct gaagctgaga caggccgaag tgatcaaggg     3240

cagctggcag cctgtgggcg atctgctgat cgactccctg caggatcacc tggagaaagt     3300

gaaggccctg cggggcgaga tcgcccccct gaaggagaat gtgagccacg tgaacgacct     3360

ggccagacag ctgaccaccc tgggcatcca gctgagcccc tacaacctga gcacactgga     3420

ggatctgaac acccggtgga aactgctgca ggtggccgtg gaggatagag tgaggcagct     3480

gcacgaagcc cacagagact tcggccctgc ctcccagcac ttcctgagca ccagcgtgca     3540

gggcccctgg gagagagcca tctcccccaa caaagtgccc tactacatca accacgagac     3600

ccagaccacc tgctgggacc accctaagat gaccgagctg tatcagagcc tggccgacct     3660

gaacaatgtg cggttcagcg cctacagaac cgccatgaag ctgcggagac tgcagaaggc     3720

cctgtgcctg gatctgctga gcctgagcgc cgcctgcgac gccctggacc agcacaacct     3780

gaagcagaat gaccagccca tggacatcct gcagatcatc aactgcctga ccacaatcta     3840

cgaccggctg gaacaggagc acaacaacct ggtgaatgtg cccctgtgcg tggacatgtg     3900

cctgaattgg ctgctgaacg tgtacgacac cggcaggacc ggcagaatcc gcgtgctgag     3960

cttcaagacc ggcatcatca gcctgtgcaa ggcccacctg gaggataagt accgctacct     4020

gttcaagcag gtggccagca gcaccggctt ctgcgatcag aggagactgg gcctgctgct     4080

gcacgatagc atccagatcc ctaggcagct gggcgaagtg gccagctttg gcggcagcaa     4140

catcgagccc tctgtgagga gctgcttcca gttcgccaac aacaagcccg agatcgaggc     4200

cgccctgttc ctggactgga tgaggctgga gcctcagagc atggtgtggc tgcctgtgct     4260

gcacagagtg gccgccgccg agaccgccaa gcaccaggcc aagtgcaata tctgcaagga     4320

gtgccccatc atcggcttcc ggtacaggag cctgaagcac ttcaactacg acatctgcca     4380

gagctgcttt ttcagcggca gagtggccaa gggccacaaa atgcactacc ccatggtgga     4440

gtactgcacc cccaccacct ccggcgagga tgtgagagac ttcgccaaag tgctgaagaa     4500

taagttccgg accaagcggt actttgccaa gcaccccagg atgggctacc tgcccgtgca     4560

gaccgtgctg gaaggcgaca acatggagac ctgatgagga gctcgagagg cctaataaag     4620

agctcagatg catcgatcag agtgtgttgg ttttttgtgt gagatctagg aacccctagt     4680

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg cccgggcaaa     4740

gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga     4800

gggagtggcc aa                                                         4812


<210>  11
<211>  4965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector genome with Hopti-Dys3837 gene

<400>  11
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcggt accccactac gggtctaggc      180

tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata attaacccca      240

acacctgctg cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt      300

ggatcccctg catgccccac tacgggttta ggctgcccat gtaaggaggc aaggcctggg      360

gacacccgag atgcctggtt ataattaacc cagacatgtg gctgcccccc ccccccccaa      420

cacctgctgc ctctaaaaat aaccctgtcc ctggtggatc ccctgcatgc gaagatcttc      480

gaacaaggct gtgggggact gagggcaggc tgtaacaggc ttgggggcca gggcttatac      540

gtgcctggga ctcccaaagt attactgttc catgttcccg gcgaagggcc agctgtcccc      600

cgccagctag actcagcact tagtttagga accagtgagc aagtcagccc ttggggcagc      660

ccatacaagg ccatggggct gggcaagctg cacgcctggg tccggggtgg gcacggtgcc      720

cgggcaacga gctgaaagct catctgctct caggggcccc tccctgggga cagcccctcc      780

tggctagtca caccctgtag gctcctctat ataacccagg ggcacagggg ctgccctcat      840

tctaccacca cctccacagc acagacagac actcaggagc cagccagcgt cgagcggccg      900

atccgccacc atgctttggt gggaggaagt ggaggactgc tacgagagag aggacgtgca      960

gaagaaaacc ttcaccaagt gggtgaacgc ccagttcagc aagttcggca agcagcacat     1020

cgagaacctg ttcagcgacc tgcaggatgg caggagactg ctggacctgc tggagggcct     1080

gaccggccag aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt     1140

gaacaaggcc ctgagagtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac     1200

cgacatcgtg gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca     1260

ctggcaggtg aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga     1320

gaagatcctg ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat     1380

caacttcacc acctcctgga gcgacggcct ggccctgaac gccctgatcc acagccacag     1440

acccgacctg ttcgactgga acagcgtggt gtgtcagcag agcgccaccc agagactgga     1500

gcacgccttc aacatcgcca gataccagct gggcatcgag aagctgctgg accccgagga     1560

cgtggacacc acctaccccg acaagaaaag catcctcatg tacattacca gcctgttcca     1620

ggtgctgccc cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccaggcc     1680

ccccaaagtg accaaggagg agcacttcca gctgcaccac cagatgcact acagccagca     1740

gatcacagtg agcctggccc agggctatga gagaaccagc agccccaagc ccagattcaa     1800

gagctacgcc tacacccagg ccgcctacgt gaccacctcc gaccccacca gaagcccctt     1860

ccccagccag cacctggagg cccccgagga caagagcttc ggcagcagcc tgatggagag     1920

cgaagtgaac ctggacagat accagaccgc cctggaggaa gtgctgtcct ggctgctgag     1980

cgccgaggac accctgcagg cccagggcga gatcagcaac gacgtggaag tggtgaagga     2040

ccagttccac acccacgagg gctacatgat ggatctgacc gcccaccagg gcagagtggg     2100

caatatcctg cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgagga     2160

gaccgaagtg caggagcaga tgaacctgct gaacagcaga tgggagtgcc tgagagtggc     2220

cagcatggag aagcagagca acctgcacag agtgctgatg gacctgcaga accagaagct     2280

gaaggagctg aacgactggc tgaccaagac cgaggagcgg accagaaaga tggaggagga     2340

gcccctgggc cccgacctgg aggacctgaa gagacaggtg cagcagcaca aagtgctgca     2400

ggaggacctg gagcaggagc aggtgcgcgt gaacagcctg acccacatgg tggtggtcgt     2460

ggacgagagc agcggcgacc acgccacagc cgccctggaa gagcagctga aagtgctggg     2520

cgacagatgg gccaatattt gtaggtggac cgaggacaga tgggtgctgc tgcaggacac     2580

ccaccgcctg ctccagcagt tccccctgga cctggagaag ttcctggcct ggctgaccga     2640

ggccgaaacc accgccaatg tgctccagga cgccactaga aaggagaggc tgctggagga     2700

cagcaagggc gtgaaagagc tgatgaagca gtggcaggat ctgcagggcg aaatcgaggc     2760

ccacaccgac gtgtaccaca acctggacga gaacagccag aagattctga ggagcctgga     2820

gggcagcgac gacgccgtcc tgctccagag gaggctggac aacatgaact tcaagtggag     2880

cgagctgcgg aagaagagcc tgaacatccg gagccacctg gaagccagca gcgaccagtg     2940

gaagagactg cacctgagcc tgcaggagct gctggtgtgg ctgcagctga aggacgacga     3000

gctgagcaga caggccccca tcggcggcga cttccccgcc gtgcagaagc agaacgacgt     3060

gcaccgggcc ttcaagaggg agctgaaaac caaggaaccc gtgatcatga gcaccctgga     3120

gacagtgcgg atcttcctga ccgagcagcc cctggaggga ctggagaagc tgtaccagga     3180

gcccagagag ctgccccccg aggagagagc ccagaacgtg accaggctgc tgagaaagca     3240

ggccgaggaa gtgaataccg agtgggagaa gctgaatctg cacagcgccg actggcagag     3300

aaagatcgac gagaccctgg agagactcca ggaactgcag gaagccaccg acgagctgga     3360

cctgaagctg agacaggccg aagtgatcaa gggcagctgg cagcctgtgg gcgatctgct     3420

gatcgactcc ctgcaggatc acctggagaa agtgaaggcc ctgcggggcg agatcgcccc     3480

cctgaaggag aatgtgagcc acgtgaacga cctggccaga cagctgacca ccctgggcat     3540

ccagctgagc ccctacaacc tgagcacact ggaggatctg aacacccggt ggaaactgct     3600

gcaggtggcc gtggaggata gagtgaggca gctgcacgaa gcccacagag acttcggccc     3660

tgcctcccag cacttcctga gcaccagcgt gcagggcccc tgggagagag ccatctcccc     3720

caacaaagtg ccctactaca tcaaccacga gacccagacc acctgctggg accaccctaa     3780

gatgaccgag ctgtatcaga gcctggccga cctgaacaat gtgcggttca gcgcctacag     3840

aaccgccatg aagctgcgga gactgcagaa ggccctgtgc ctggatctgc tgagcctgag     3900

cgccgcctgc gacgccctgg accagcacaa cctgaagcag aatgaccagc ccatggacat     3960

cctgcagatc atcaactgcc tgaccacaat ctacgaccgg ctggaacagg agcacaacaa     4020

cctggtgaat gtgcccctgt gcgtggacat gtgcctgaat tggctgctga acgtgtacga     4080

caccggcagg accggcagaa tccgcgtgct gagcttcaag accggcatca tcagcctgtg     4140

caaggcccac ctggaggata agtaccgcta cctgttcaag caggtggcca gcagcaccgg     4200

cttctgcgat cagaggagac tgggcctgct gctgcacgat agcatccaga tccctaggca     4260

gctgggcgaa gtggccagct ttggcggcag caacatcgag ccctctgtga ggagctgctt     4320

ccagttcgcc aacaacaagc ccgagatcga ggccgccctg ttcctggact ggatgaggct     4380

ggagcctcag agcatggtgt ggctgcctgt gctgcacaga gtggccgccg ccgagaccgc     4440

caagcaccag gccaagtgca atatctgcaa ggagtgcccc atcatcggct tccggtacag     4500

gagcctgaag cacttcaact acgacatctg ccagagctgc tttttcagcg gcagagtggc     4560

caagggccac aaaatgcact accccatggt ggagtactgc acccccacca cctccggcga     4620

ggatgtgaga gacttcgcca aagtgctgaa gaataagttc cggaccaagc ggtactttgc     4680

caagcacccc aggatgggct acctgcccgt gcagaccgtg ctggaaggcg acaacatgga     4740

gacctgatga ggagctcgag aggcctaata aagagctcag atgcatcgat cagagtgtgt     4800

tggttttttg tgtgagatct aggaacccct agtgatggag ttggccactc cctctctgcg     4860

cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg     4920

cccggcctca gtgagcgagc gagcgcgcag agagggagtg gccaa                     4965


<210>  12
<211>  4955
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector genome with Copti-Dys3978 gene

<400>  12
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg taccccacta cgggtttagg      180

ctgcccatgt aaggaggcaa ggcctgggga cacccgagat gcctggttat aattaaccca      240

gacatgtggc tgcccccccc ccccccaaca cctgctgcct ctaaaaataa ccctgtccct      300

ggtggatccc ctgcatgcga agatcttcga acaaggctgt gggggactga gggcaggctg      360

taacaggctt gggggccagg gcttatacgt gcctgggact cccaaagtat tactgttcca      420

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      480

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      540

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      600

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      660

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac      720

tcaggagcca gccagcgtcg agcggccgcc accatgcttt ggtgggagga agtggaggac      780

tgctacgagc gggaggacgt gcagaagaaa accttcacca agtgggtgaa cgcccagttc      840

agcaagttcg gcaagcagca catcgagaac ctgttcagcg acctgcagga cggcaggcgg      900

ctgctggacc tcctggaagg cctgaccggc cagaagctgc ccaaagagaa gggcagcacc      960

agggtgcacg ccctgaacaa cgtgaacaag gccctgaggg tgctgcagaa caacaacgtg     1020

gacctggtga acatcggcag caccgacatc gtggacggca accacaagct gaccctgggc     1080

ctgatctgga acatcatcct gcactggcag gtcaagaacg tgatgaagaa catcatggcc     1140

ggcctgcagc agaccaacag cgagaagatc ctgctgtcct gggtgcggca gagcaccagg     1200

aactaccccc aggtcaacgt gatcaacttc accacctctt ggagcgacgg cctggccctg     1260

aacgccctga tccacagcca caggcccgac ctgttcgact ggaacagcgt ggtgtgccag     1320

cagagcgcca cccagaggct ggaacacgcc ttcaacatcg ccagatacca gctgggcatc     1380

gagaagctgc tggatcccga ggacgtggac accacctacc ccgacaagaa aagcatcctc     1440

atgtacatca ccagcctgtt ccaggtgctg ccccagcagg tgtccatcga ggccatccag     1500

gaagtggaga tgctgcccag gccccccaag gtcaccaaag aggaacactt ccagctgcac     1560

caccagatgc actacagcca gcagatcacc gtgagcctgg cccagggcta cgagaggacc     1620

agcagcccca agcccaggtt caagagctac gcctacaccc aggccgccta cgtgaccacc     1680

tccgacccca ccaggtcccc cttccccagc cagcatctcg aagcccccga ggacaagagc     1740

ttcggcagca gcctgatgga aagcgaggtg aacctggaca gataccagac cgccctggaa     1800

gaagtgctgt cttggctgct gtccgccgag gacaccctgc aggcccaggg cgagatcagc     1860

aacgacgtgg aggtcgtgaa ggaccagttc cacacccacg agggctacat gatggacctg     1920

accgcccacc agggcagagt gggcaacatc ctgcagctgg gcagcaagct gatcggcacc     1980

ggcaagctgt ccgaggacga ggaaaccgag gtgcaggaac agatgaacct gctgaacagc     2040

agatgggagt gcctgagggt ggccagcatg gaaaagcaga gcaacctgca cagggtgctg     2100

atggatctgc agaaccagaa gctcaaagag ctgaacgact ggctgaccaa gaccgaggaa     2160

aggacccgga agatggaaga ggaacccctg ggccccgatc tcgaagatct gaagaggcag     2220

gtgcagcagc acaaggtgct gcaggaagat ctcgaacagg aacaggtccg ggtcaacagc     2280

ctgacccaca tggtcgtggt ggtggacgag agcagcggcg accacgccac cgctgccctg     2340

gaagagcagc tgaaggtgct gggcgacaga tgggccaaca tctgccggtg gaccgaggac     2400

agatgggtcc tcctgcagga ccagcccgac ctggcccctg gcctgacaac catcggcgcc     2460

agccccaccc agaccgtgac cctggtgacc cagcccgtgg tgaccaaaga gaccgccatc     2520

agcaagctgg aaatgcccag ctccctgatg ctggaagtgc ccacccacag gctcctccag     2580

cagttccccc tggacctgga aaagttcctg gcctggctga ccgaggccga gaccaccgcc     2640

aacgtgctgc aggacgccac caggaaagag aggctgctgg aagatagcaa gggcgtgaaa     2700

gagctgatga agcagtggca ggacctgcag ggggagattg aggcccacac cgacgtgtac     2760

cacaacctgg acgagaacag ccagaaaatc ctgagaagcc tggaaggcag cgacgacgcc     2820

gtgctgctgc agaggcggct ggacaacatg aacttcaagt ggagcgagct gaggaagaag     2880

agcctgaaca tcaggtccca tctggaagcc agcagcgacc agtggaagag gctgcacctg     2940

agcctgcagg aactgctcgt ctggctgcag ctgaaagacg acgagctgtc caggcaggcc     3000

cccatcggcg gcgacttccc cgccgtgcag aaacagaacg acgtgcacag ggccttcaag     3060

cgggagctga aaaccaaaga gcccgtgatc atgagcaccc tggaaaccgt gaggatcttc     3120

ctgaccgagc agcccctgga aggactggaa aagctgtacc aggaacccag agagctgccc     3180

cccgaggaac gggcccagaa cgtgaccagg ctgctgagaa agcaggccga ggaagtgaac     3240

accgagtggg agaagctgaa cctgcactcc gccgactggc agaggaagat cgacgagacc     3300

ctggaaaggc tccaggaact gcaggaagcc accgacgagc tggacctgaa gctgagacag     3360

gccgaggtga tcaagggcag ctggcagccc gtgggcgacc tgctgatcga ctccctgcag     3420

gatcacctgg aaaaagtgaa ggccctgcgg ggcgagatcg cccccctgaa agagaacgtc     3480

agccacgtca acgacctggc caggcagctg accaccctgg gcatccagct gtccccctac     3540

aacctgtcca ccctggaaga tctgaacaca aggtggaagc tgctgcaggt ggccgtggag     3600

gacagagtga ggcagctgca cgaggcccac agggacttcg gccctgcctc ccagcacttc     3660

ctgagcacca gcgtgcaggg cccctgggag agggccatct cccccaacaa ggtgccctac     3720

tacatcaacc acgagaccca gaccacctgc tgggaccacc ctaagatgac cgagctgtac     3780

cagtccctgg ccgacctgaa caatgtgcgg ttcagcgcct accggaccgc catgaagctg     3840

aggcggctgc agaaagccct gtgcctggat ctgctgtccc tgagcgccgc ctgcgacgcc     3900

ctggaccagc acaacctgaa gcagaacgac cagcccatgg atatcctgca gatcatcaac     3960

tgtctgacca ccatctacga caggctggaa caggaacaca acaacctggt caacgtgccc     4020

ctgtgcgtgg acatgtgcct gaactggctg ctgaacgtgt acgacaccgg caggaccggc     4080

cggatcaggg tgctgtcctt caagaccggc atcatcagcc tgtgcaaggc ccacctggaa     4140

gataagtacc gctacctgtt caagcaggtg gccagctcta ccggcttctg cgaccagcgg     4200

aggctgggcc tgctgctgca cgacagcatc cagatccccc ggcagctggg cgaggtggcc     4260

tccttcggcg gcagcaacat cgagcccagc gtgcggagct gcttccagtt cgccaacaac     4320

aagcccgaga tcgaggccgc cctgttcctg gactggatgc ggctggaacc ccagagcatg     4380

gtctggctgc ccgtgctgca cagagtggct gccgccgaga ccgccaagca ccaggccaag     4440

tgcaacatct gcaaagagtg ccccatcatc ggcttcaggt acagaagcct gaagcacttc     4500

aactacgaca tctgccagag ctgtttcttc agcggcaggg tggccaaggg ccacaaaatg     4560

cactacccca tggtggagta ctgcaccccc accacctccg gcgaggacgt gagggacttc     4620

gccaaggtgc tgaagaataa gttccggacc aagcggtact tcgccaaaca ccccaggatg     4680

ggctacctgc ccgtgcagac cgtgctggaa ggcgacaaca tggaaacctg ataacacgcg     4740

tcgactcgag aggcctaata aagagctcag atgcatcgat cagagtgtgt tggttttttg     4800

tgtgagatct aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4860

ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca     4920

gtgagcgagc gagcgcgcag agagggagtg gccaa                                4955


<210>  13
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  14
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  15
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  16
<211>  577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic enhancer and promoter

<400>  16
ccactacggg tctaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg      180

gactgagggc aggctgtaac aggcttgggg gccagggctt atacgtgcct gggactccca      240

aagtattact gttccatgtt cccggcgaag ggccagctgt cccccgccag ctagactcag      300

cacttagttt aggaaccagt gagcaagtca gcccttgggg cagcccatac aaggccatgg      360

ggctgggcaa gctgcacgcc tgggtccggg gtgggcacgg tgcccgggca acgagctgaa      420

agctcatctg ctctcagggg cccctccctg gggacagccc ctcctggcta gtcacaccct      480

gtaggctcct ctatataacc caggggcaca ggggctgccc tcattctacc accacctcca      540

cagcacagac agacactcag gagccagcca gcgtcga                               577


<210>  17
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic transcription terminator

<400>  17
aggcctaata aagagctcag atgcatcgat cagagtgtgt tggttttttg tgtg             54


<210>  18
<211>  4955
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector genome with Hopti-Dys3978 gene

<400>  18
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg taccccacta cgggtctagg      180

ctgcccatgt aaggaggcaa ggcctgggga cacccgagat gcctggttat aattaaccca      240

gacatgtggc tgcccccccc ccccccaaca cctgctgcct ctaaaaataa ccctgtccct      300

ggtggatccc ctgcatgcga agatcttcga acaaggctgt gggggactga gggcaggctg      360

taacaggctt gggggccagg gcttatacgt gcctgggact cccaaagtat tactgttcca      420

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      480

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      540

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      600

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      660

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac      720

tcaggagcca gccagcgtcg agcggccgat ccgccaccat gctttggtgg gaggaagtgg      780

aggactgcta cgagagagag gacgtgcaga agaaaacctt caccaagtgg gtgaacgccc      840

agttcagcaa gttcggcaag cagcacatcg agaacctgtt cagcgacctg caggatggca      900

ggagactgct ggacctgctg gagggcctga ccggccagaa gctgcccaag gagaagggca      960

gcaccagagt gcacgccctg aacaacgtga acaaggccct gagagtgctg cagaacaaca     1020

acgtggacct ggtgaacatc ggcagcaccg acatcgtgga cggcaaccac aagctgaccc     1080

tgggcctgat ctggaacatc atcctgcact ggcaggtgaa gaacgtgatg aagaacatca     1140

tggccggcct gcagcagacc aacagcgaga agatcctgct gagctgggtg aggcagagca     1200

ccagaaacta cccccaggtg aacgtgatca acttcaccac ctcctggagc gacggcctgg     1260

ccctgaacgc cctgatccac agccacagac ccgacctgtt cgactggaac agcgtggtgt     1320

gtcagcagag cgccacccag agactggagc acgccttcaa catcgccaga taccagctgg     1380

gcatcgagaa gctgctggac cccgaggacg tggacaccac ctaccccgac aagaaaagca     1440

tcctcatgta cattaccagc ctgttccagg tgctgcccca gcaggtgtcc atcgaggcca     1500

tccaggaagt ggaaatgctg cccaggcccc ccaaagtgac caaggaggag cacttccagc     1560

tgcaccacca gatgcactac agccagcaga tcacagtgag cctggcccag ggctatgaga     1620

gaaccagcag ccccaagccc agattcaaga gctacgccta cacccaggcc gcctacgtga     1680

ccacctccga ccccaccaga agccccttcc ccagccagca cctggaggcc cccgaggaca     1740

agagcttcgg cagcagcctg atggagagcg aagtgaacct ggacagatac cagaccgccc     1800

tggaggaagt gctgtcctgg ctgctgagcg ccgaggacac cctgcaggcc cagggcgaga     1860

tcagcaacga cgtggaagtg gtgaaggacc agttccacac ccacgagggc tacatgatgg     1920

atctgaccgc ccaccagggc agagtgggca atatcctgca gctgggcagc aagctgatcg     1980

gcaccggcaa gctgagcgag gacgaggaga ccgaagtgca ggagcagatg aacctgctga     2040

acagcagatg ggagtgcctg agagtggcca gcatggagaa gcagagcaac ctgcacagag     2100

tgctgatgga cctgcagaac cagaagctga aggagctgaa cgactggctg accaagaccg     2160

aggagcggac cagaaagatg gaggaggagc ccctgggccc cgacctggag gacctgaaga     2220

gacaggtgca gcagcacaaa gtgctgcagg aggacctgga gcaggagcag gtgcgcgtga     2280

acagcctgac ccacatggtg gtggtcgtgg acgagagcag cggcgaccac gccacagccg     2340

ccctggaaga gcagctgaaa gtgctgggcg acagatgggc caatatttgt aggtggaccg     2400

aggacagatg ggtgctgctg caggaccagc ccgacctggc ccctggcctg accaccatcg     2460

gcgccagccc cacccagacc gtgaccctgg tgacccagcc cgtggtgaca aaggagaccg     2520

ccatcagcaa gctggagatg cccagctccc tgatgctgga agtgcccacc caccgcctgc     2580

tccagcagtt ccccctggac ctggagaagt tcctggcctg gctgaccgag gccgaaacca     2640

ccgccaatgt gctccaggac gccactagaa aggagaggct gctggaggac agcaagggcg     2700

tgaaagagct gatgaagcag tggcaggatc tgcagggcga aatcgaggcc cacaccgacg     2760

tgtaccacaa cctggacgag aacagccaga agattctgag gagcctggag ggcagcgacg     2820

acgccgtcct gctccagagg aggctggaca acatgaactt caagtggagc gagctgcgga     2880

agaagagcct gaacatccgg agccacctgg aagccagcag cgaccagtgg aagagactgc     2940

acctgagcct gcaggagctg ctggtgtggc tgcagctgaa ggacgacgag ctgagcagac     3000

aggcccccat cggcggcgac ttccccgccg tgcagaagca gaacgacgtg caccgggcct     3060

tcaagaggga gctgaaaacc aaggaacccg tgatcatgag caccctggag acagtgcgga     3120

tcttcctgac cgagcagccc ctggagggac tggagaagct gtaccaggag cccagagagc     3180

tgccccccga ggagagagcc cagaacgtga ccaggctgct gagaaagcag gccgaggaag     3240

tgaataccga gtgggagaag ctgaatctgc acagcgccga ctggcagaga aagatcgacg     3300

agaccctgga gagactccag gaactgcagg aagccaccga cgagctggac ctgaagctga     3360

gacaggccga agtgatcaag ggcagctggc agcctgtggg cgatctgctg atcgactccc     3420

tgcaggatca cctggagaaa gtgaaggccc tgcggggcga gatcgccccc ctgaaggaga     3480

atgtgagcca cgtgaacgac ctggccagac agctgaccac cctgggcatc cagctgagcc     3540

cctacaacct gagcacactg gaggatctga acacccggtg gaaactgctg caggtggccg     3600

tggaggatag agtgaggcag ctgcacgaag cccacagaga cttcggccct gcctcccagc     3660

acttcctgag caccagcgtg cagggcccct gggagagagc catctccccc aacaaagtgc     3720

cctactacat caaccacgag acccagacca cctgctggga ccaccctaag atgaccgagc     3780

tgtatcagag cctggccgac ctgaacaatg tgcggttcag cgcctacaga accgccatga     3840

agctgcggag actgcagaag gccctgtgcc tggatctgct gagcctgagc gccgcctgcg     3900

acgccctgga ccagcacaac ctgaagcaga atgaccagcc catggacatc ctgcagatca     3960

tcaactgcct gaccacaatc tacgaccggc tggaacagga gcacaacaac ctggtgaatg     4020

tgcccctgtg cgtggacatg tgcctgaatt ggctgctgaa cgtgtacgac accggcagga     4080

ccggcagaat ccgcgtgctg agcttcaaga ccggcatcat cagcctgtgc aaggcccacc     4140

tggaggataa gtaccgctac ctgttcaagc aggtggccag cagcaccggc ttctgcgatc     4200

agaggagact gggcctgctg ctgcacgata gcatccagat ccctaggcag ctgggcgaag     4260

tggccagctt tggcggcagc aacatcgagc cctctgtgag gagctgcttc cagttcgcca     4320

acaacaagcc cgagatcgag gccgccctgt tcctggactg gatgaggctg gagcctcaga     4380

gcatggtgtg gctgcctgtg ctgcacagag tggccgccgc cgagaccgcc aagcaccagg     4440

ccaagtgcaa tatctgcaag gagtgcccca tcatcggctt ccggtacagg agcctgaagc     4500

acttcaacta cgacatctgc cagagctgct ttttcagcgg cagagtggcc aagggccaca     4560

aaatgcacta ccccatggtg gagtactgca cccccaccac ctccggcgag gatgtgagag     4620

acttcgccaa agtgctgaag aataagttcc ggaccaagcg gtactttgcc aagcacccca     4680

ggatgggcta cctgcccgtg cagaccgtgc tggaaggcga caacatggag acctgatgag     4740

gagctcgaga ggcctaataa agagctcaga tgcatcgatc agagtgtgtt ggttttttgt     4800

gtgagatctg aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4860

ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca     4920

gtgagcgagc gagcgcgcag agagggagtg gccaa                                4955


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
ccaacaaagt gccctactac atc                                               23


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
ggttgtgctg gtccagggcg t                                                 21


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
ccgagctgta tcagagcctg gcc                                               23


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  22
gcgaaagtgg aaaagccaag t                                                 21


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  23
gccacatcaa caggactctt gtag                                              24


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
caaagcctaa aagacagcgg caagttgaat                                        30


<210>  25
<211>  3685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  26
<211>  3978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-codon optimized Dys3978 gene

<400>  26
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agttttaatg gatctccaga atcagaaact gaaagagttg     1380

aatgactggc taacaaaaac agaagaaaga acaaggaaaa tggaggaaga gcctcttgga     1440

cctgatcttg aagacctaaa acgccaagta caacaacata aggtgcttca agaagatcta     1500

gaacaagaac aagtcagggt caattctctc actcacatgg tggtggtagt tgatgaatct     1560

agtggagatc acgcaactgc tgctttggaa gaacaactta aggtattggg agatcgatgg     1620

gcaaacatct gtagatggac agaagaccgc tgggttcttt tacaagacca gcctgaccta     1680

gctcctggac tgaccactat tggagcctct cctactcaga ctgttactct ggtgacacaa     1740

cctgtggtta ctaaggaaac tgccatctcc aaactagaaa tgccatcttc cttgatgttg     1800

gaggtaccta ctcatagatt actgcaacag ttccccctgg acctggaaaa gtttcttgcc     1860

tggcttacag aagctgaaac aactgccaat gtcctacagg atgctacccg taaggaaagg     1920

ctcctagaag actccaaggg agtaaaagag ctgatgaaac aatggcaaga cctccaaggt     1980

gaaattgaag ctcacacaga tgtttatcac aacctggatg aaaacagcca aaaaatcctg     2040

agatccctgg aaggttccga tgatgcagtc ctgttacaaa gacgtttgga taacatgaac     2100

ttcaagtgga gtgaacttcg gaaaaagtct ctcaacatta ggtcccattt ggaagccagt     2160

tctgaccagt ggaagcgtct gcacctttct ctgcaggaac ttctggtgtg gctacagctg     2220

aaagatgatg aattaagccg gcaggcacct attggaggcg actttccagc agttcagaag     2280

cagaacgatg tacatagggc cttcaagagg gaattgaaaa ctaaagaacc tgtaatcatg     2340

agtactcttg agactgtacg aatatttctg acagagcagc ctttggaagg actagagaaa     2400

ctctaccagg agcccagaga gctgcctcct gaggagagag cccagaatgt cactcggctt     2460

ctacgaaagc aggctgagga ggtcaatact gagtgggaaa aattgaacct gcactccgct     2520

gactggcaga gaaaaataga tgagaccctt gaaagactcc aggaacttca agaggccacg     2580

gatgagctgg acctcaagct gcgccaagct gaggtgatca agggatcctg gcagcccgtg     2640

ggcgatctcc tcattgactc tctccaagat cacctcgaga aagtcaaggc acttcgagga     2700

gaaattgcgc ctctgaaaga gaacgtgagc cacgtcaatg accttgctcg ccagcttacc     2760

actttgggca ttcagctctc accgtataac ctcagcactc tggaagacct gaacaccaga     2820

tggaagcttc tgcaggtggc cgtcgaggac cgagtcaggc agctgcatga agcccacagg     2880

gactttggtc cagcatctca gcactttctt tccacgtctg tccagggtcc ctgggagaga     2940

gccatctcgc caaacaaagt gccctactat atcaaccacg agactcaaac aacttgctgg     3000

gaccatccca aaatgacaga gctctaccag tctttagctg acctgaataa tgtcagattc     3060

tcagcttata ggactgccat gaaactccga agactgcaga aggccctttg cttggatctc     3120

ttgagcctgt cagctgcatg tgatgccttg gaccagcaca acctcaagca aaatgaccag     3180

cccatggata tcctgcagat tattaattgt ttgaccacta tttatgaccg cctggagcaa     3240

gagcacaaca atttggtcaa cgtccctctc tgcgtggata tgtgtctgaa ctggctgctg     3300

aatgtttatg atacgggacg aacagggagg atccgtgtcc tgtcttttaa aactggcatc     3360

atttccctgt gtaaagcaca tttggaagac aagtacagat accttttcaa gcaagtggca     3420

agttcaacag gattttgtga ccagcgcagg ctgggcctcc ttctgcatga ttctatccaa     3480

attccaagac agttgggtga agttgcatcc tttgggggca gtaacattga gccaagtgtc     3540

cggagctgct tccaatttgc taataataag ccagagatcg aagcggccct cttcctagac     3600

tggatgagac tggaacccca gtccatggtg tggctgcccg tcctgcacag agtggctgct     3660

gcagaaactg ccaagcatca ggccaaatgt aacatctgca aagagtgtcc aatcattgga     3720

ttcaggtaca ggagtctaaa gcactttaat tatgacatct gccaaagctg ctttttttct     3780

ggtcgagttg caaaaggcca taaaatgcac tatcccatgg tggaatattg cactccgact     3840

acatcaggag aagatgttcg agactttgcc aaggtactaa aaaacaaatt tcgaaccaaa     3900

aggtattttg cgaagcatcc ccgaatgggc tacctgccag tgcagactgt cttagagggg     3960

gacaacatgg aaacttag                                                   3978


<210>  27
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta3990 protein

<400>  27

Met Val Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Gln Pro Asp Leu 
545                 550                 555                 560 


Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr 
                565                 570                 575     


Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 
            580                 585                 590         


Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr His Arg Leu Leu 
        595                 600                 605             


Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu 
    610                 615                 620                 


Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg 
625                 630                 635                 640 


Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln 
                645                 650                 655     


Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu 
            660                 665                 670         


Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp 
        675                 680                 685             


Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser 
    690                 695                 700                 


Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser 
705                 710                 715                 720 


Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 
                725                 730                 735     


Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly 
            740                 745                 750         


Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe 
        755                 760                 765             


Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu 
    770                 775                 780                 


Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
785                 790                 795                 800 


Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 
                805                 810                 815     


Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp 
            820                 825                 830         


Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu 
        835                 840                 845             


Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 
    850                 855                 860                 


Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val 
865                 870                 875                 880 


Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 
                885                 890                 895     


Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 
            900                 905                 910         


Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 
        915                 920                 925             


Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 
    930                 935                 940                 


Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg 
945                 950                 955                 960 


Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
                965                 970                 975     


Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn 
            980                 985                 990         


His Glu Thr Gln Thr Thr Cys Trp  Asp His Pro Lys Met  Thr Glu Leu 
        995                 1000                 1005             


Tyr Gln  Ser Leu Ala Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr 
    1010                 1015                 1020             


Arg Thr  Ala Met Lys Leu Arg  Arg Leu Gln Lys Ala  Leu Cys Leu 
    1025                 1030                 1035             


Asp Leu  Leu Ser Leu Ser Ala  Ala Cys Asp Ala Leu  Asp Gln His 
    1040                 1045                 1050             


Asn Leu  Lys Gln Asn Asp Gln  Pro Met Asp Ile Leu  Gln Ile Ile 
    1055                 1060                 1065             


Asn Cys  Leu Thr Thr Ile Tyr  Asp Arg Leu Glu Gln  Glu His Asn 
    1070                 1075                 1080             


Asn Leu  Val Asn Val Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp 
    1085                 1090                 1095             


Leu Leu  Asn Val Tyr Asp Thr  Gly Arg Thr Gly Arg  Ile Arg Val 
    1100                 1105                 1110             


Leu Ser  Phe Lys Thr Gly Ile  Ile Ser Leu Cys Lys  Ala His Leu 
    1115                 1120                 1125             


Glu Asp  Lys Tyr Arg Tyr Leu  Phe Lys Gln Val Ala  Ser Ser Thr 
    1130                 1135                 1140             


Gly Phe  Cys Asp Gln Arg Arg  Leu Gly Leu Leu Leu  His Asp Ser 
    1145                 1150                 1155             


Ile Gln  Ile Pro Arg Gln Leu  Gly Glu Val Ala Ser  Phe Gly Gly 
    1160                 1165                 1170             


Ser Asn  Ile Glu Pro Ser Val  Arg Ser Cys Phe Gln  Phe Ala Asn 
    1175                 1180                 1185             


Asn Lys  Pro Glu Ile Glu Ala  Ala Leu Phe Leu Asp  Trp Met Arg 
    1190                 1195                 1200             


Leu Glu  Pro Gln Ser Met Val  Trp Leu Pro Val Leu  His Arg Val 
    1205                 1210                 1215             


Ala Ala  Ala Glu Thr Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys 
    1220                 1225                 1230             


Lys Glu  Cys Pro Ile Ile Gly  Phe Arg Tyr Arg Ser  Leu Lys His 
    1235                 1240                 1245             


Phe Asn  Tyr Asp Ile Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Val 
    1250                 1255                 1260             


Ala Lys  Gly His Lys Met His  Tyr Pro Met Val Glu  Tyr Cys Thr 
    1265                 1270                 1275             


Pro Thr  Thr Ser Gly Glu Asp  Val Arg Asp Phe Ala  Lys Val Leu 
    1280                 1285                 1290             


Lys Asn  Lys Phe Arg Thr Lys  Arg Tyr Phe Ala Lys  His Pro Arg 
    1295                 1300                 1305             


Met Gly  Tyr Leu Pro Val Gln  Thr Val Leu Glu Gly  Asp Asn Met 
    1310                 1315                 1320             


Glu Thr  Pro Asp Thr Met 
    1325                 


<210>  28
<211>  3990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta3990 gene

<400>  28
atggtttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agttttaatg gatctccaga atcagaaact gaaagagttg     1380

aatgactggc taacaaaaac agaagaaaga acaaggaaaa tggaggaaga gcctcttgga     1440

cctgatcttg aagacctaaa acgccaagta caacaacata aggtgcttca agaagatcta     1500

gaacaagaac aagtcagggt caattctctc actcacatgg tggtggtagt tgatgaatct     1560

agtggagatc acgcaactgc tgctttggaa gaacaactta aggtattggg agatcgatgg     1620

gcaaacatct gtagatggac agaagaccgc tgggttcttt tacaagacca gcctgaccta     1680

gctcctggac tgaccactat tggagcctct cctactcaga ctgttactct ggtgacacaa     1740

cctgtggtta ctaaggaaac tgccatctcc aaactagaaa tgccatcttc cttgatgttg     1800

gaggtaccta ctcatagatt actgcaacag ttccccctgg acctggaaaa gtttcttgcc     1860

tggcttacag aagctgaaac aactgccaat gtcctacagg atgctacccg taaggaaagg     1920

ctcctagaag actccaaggg agtaaaagag ctgatgaaac aatggcaaga cctccaaggt     1980

gaaattgaag ctcacacaga tgtttatcac aacctggatg aaaacagcca aaaaatcctg     2040

agatccctgg aaggttccga tgatgcagtc ctgttacaaa gacgtttgga taacatgaac     2100

ttcaagtgga gtgaacttcg gaaaaagtct ctcaacatta ggtcccattt ggaagccagt     2160

tctgaccagt ggaagcgtct gcacctttct ctgcaggaac ttctggtgtg gctacagctg     2220

aaagatgatg aattaagccg gcaggcacct attggaggcg actttccagc agttcagaag     2280

cagaacgatg tacatagggc cttcaagagg gaattgaaaa ctaaagaacc tgtaatcatg     2340

agtactcttg agactgtacg aatatttctg acagagcagc ctttggaagg actagagaaa     2400

ctctaccagg agcccagaga gctgcctcct gaggagagag cccagaatgt cactcggctt     2460

ctacgaaagc aggctgagga ggtcaatact gagtgggaaa aattgaacct gcactccgct     2520

gactggcaga gaaaaataga tgagaccctt gaaagactcc aggaacttca agaggccacg     2580

gatgagctgg acctcaagct gcgccaagct gaggtgatca agggatcctg gcagcccgtg     2640

ggcgatctcc tcattgactc tctccaagat cacctcgaga aagtcaaggc acttcgagga     2700

gaaattgcgc ctctgaaaga gaacgtgagc cacgtcaatg accttgctcg ccagcttacc     2760

actttgggca ttcagctctc accgtataac ctcagcactc tggaagacct gaacaccaga     2820

tggaagcttc tgcaggtggc cgtcgaggac cgagtcaggc agctgcatga agcccacagg     2880

gactttggtc cagcatctca gcactttctt tccacgtctg tccagggtcc ctgggagaga     2940

gccatctcgc caaacaaagt gccctactat atcaaccacg agactcaaac aacttgctgg     3000

gaccatccca aaatgacaga gctctaccag tctttagctg acctgaataa tgtcagattc     3060

tcagcttata ggactgccat gaaactccga agactgcaga aggccctttg cttggatctc     3120

ttgagcctgt cagctgcatg tgatgccttg gaccagcaca acctcaagca aaatgaccag     3180

cccatggata tcctgcagat tattaattgt ttgaccacta tttatgaccg cctggagcaa     3240

gagcacaaca atttggtcaa cgtccctctc tgcgtggata tgtgtctgaa ctggctgctg     3300

aatgtttatg atacgggacg aacagggagg atccgtgtcc tgtcttttaa aactggcatc     3360

atttccctgt gtaaagcaca tttggaagac aagtacagat accttttcaa gcaagtggca     3420

agttcaacag gattttgtga ccagcgcagg ctgggcctcc ttctgcatga ttctatccaa     3480

attccaagac agttgggtga agttgcatcc tttgggggca gtaacattga gccaagtgtc     3540

cggagctgct tccaatttgc taataataag ccagagatcg aagcggccct cttcctagac     3600

tggatgagac tggaacccca gtccatggtg tggctgcccg tcctgcacag agtggctgct     3660

gcagaaactg ccaagcatca ggccaaatgt aacatctgca aagagtgtcc aatcattgga     3720

ttcaggtaca ggagtctaaa gcactttaat tatgacatct gccaaagctg ctttttttct     3780

ggtcgagttg caaaaggcca taaaatgcac tatcccatgg tggaatattg cactccgact     3840

acatcaggag aagatgttcg agactttgcc aaggtactaa aaaacaaatt tcgaaccaaa     3900

aggtattttg cgaagcatcc ccgaatgggc tacctgccag tgcagactgt cttagagggg     3960

gacaacatgg aaactcccga cacaatgtag                                      3990


<210>  29
<211>  3978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hopti-Dys3978 gene

<400>  29
tcaggtctcc atgttgtcgc cttccagcac ggtctgcacg ggcaggtagc ccatcctggg       60

gtgcttggca aagtaccgct tggtccggaa cttattcttc agcactttgg cgaagtctct      120

cacatcctcg ccggaggtgg tgggggtgca gtactccacc atggggtagt gcattttgtg      180

gcccttggcc actctgccgc tgaaaaagca gctctggcag atgtcgtagt tgaagtgctt      240

caggctcctg taccggaagc cgatgatggg gcactccttg cagatattgc acttggcctg      300

gtgcttggcg gtctcggcgg cggccactct gtgcagcaca ggcagccaca ccatgctctg      360

aggctccagc ctcatccagt ccaggaacag ggcggcctcg atctcgggct tgttgttggc      420

gaactggaag cagctcctca cagagggctc gatgttgctg ccgccaaagc tggccacttc      480

gcccagctgc ctagggatct ggatgctatc gtgcagcagc aggcccagtc tcctctgatc      540

gcagaagccg gtgctgctgg ccacctgctt gaacaggtag cggtacttat cctccaggtg      600

ggccttgcac aggctgatga tgccggtctt gaagctcagc acgcggattc tgccggtcct      660

gccggtgtcg tacacgttca gcagccaatt caggcacatg tccacgcaca ggggcacatt      720

caccaggttg ttgtgctcct gttccagccg gtcgtagatt gtggtcaggc agttgatgat      780

ctgcaggatg tccatgggct ggtcattctg cttcaggttg tgctggtcca gggcgtcgca      840

ggcggcgctc aggctcagca gatccaggca cagggccttc tgcagtctcc gcagcttcat      900

ggcggttctg taggcgctga accgcacatt gttcaggtcg gccaggctct gatacagctc      960

ggtcatctta gggtggtccc agcaggtggt ctgggtctcg tggttgatgt agtagggcac     1020

tttgttgggg gagatggctc tctcccaggg gccctgcacg ctggtgctca ggaagtgctg     1080

ggaggcaggg ccgaagtctc tgtgggcttc gtgcagctgc ctcactctat cctccacggc     1140

cacctgcagc agtttccacc gggtgttcag atcctccagt gtgctcaggt tgtaggggct     1200

cagctggatg cccagggtgg tcagctgtct ggccaggtcg ttcacgtggc tcacattctc     1260

cttcaggggg gcgatctcgc cccgcagggc cttcactttc tccaggtgat cctgcaggga     1320

gtcgatcagc agatcgccca caggctgcca gctgcccttg atcacttcgg cctgtctcag     1380

cttcaggtcc agctcgtcgg tggcttcctg cagttcctgg agtctctcca gggtctcgtc     1440

gatctttctc tgccagtcgg cgctgtgcag attcagcttc tcccactcgg tattcacttc     1500

ctcggcctgc tttctcagca gcctggtcac gttctgggct ctctcctcgg ggggcagctc     1560

tctgggctcc tggtacagct tctccagtcc ctccaggggc tgctcggtca ggaagatccg     1620

cactgtctcc agggtgctca tgatcacggg ttccttggtt ttcagctccc tcttgaaggc     1680

ccggtgcacg tcgttctgct tctgcacggc ggggaagtcg ccgccgatgg gggcctgtct     1740

gctcagctcg tcgtccttca gctgcagcca caccagcagc tcctgcaggc tcaggtgcag     1800

tctcttccac tggtcgctgc tggcttccag gtggctccgg atgttcaggc tcttcttccg     1860

cagctcgctc cacttgaagt tcatgttgtc cagcctcctc tggagcagga cggcgtcgtc     1920

gctgccctcc aggctcctca gaatcttctg gctgttctcg tccaggttgt ggtacacgtc     1980

ggtgtgggcc tcgatttcgc cctgcagatc ctgccactgc ttcatcagct ctttcacgcc     2040

cttgctgtcc tccagcagcc tctcctttct agtggcgtcc tggagcacat tggcggtggt     2100

ttcggcctcg gtcagccagg ccaggaactt ctccaggtcc agggggaact gctggagcag     2160

gcggtgggtg ggcacttcca gcatcaggga gctgggcatc tccagcttgc tgatggcggt     2220

ctcctttgtc accacgggct gggtcaccag ggtcacggtc tgggtggggc tggcgccgat     2280

ggtggtcagg ccaggggcca ggtcgggctg gtcctgcagc agcacccatc tgtcctcggt     2340

ccacctacaa atattggccc atctgtcgcc cagcactttc agctgctctt ccagggcggc     2400

tgtggcgtgg tcgccgctgc tctcgtccac gaccaccacc atgtgggtca ggctgttcac     2460

gcgcacctgc tcctgctcca ggtcctcctg cagcactttg tgctgctgca cctgtctctt     2520

caggtcctcc aggtcggggc ccaggggctc ctcctccatc tttctggtcc gctcctcggt     2580

cttggtcagc cagtcgttca gctccttcag cttctggttc tgcaggtcca tcagcactct     2640

gtgcaggttg ctctgcttct ccatgctggc cactctcagg cactcccatc tgctgttcag     2700

caggttcatc tgctcctgca cttcggtctc ctcgtcctcg ctcagcttgc cggtgccgat     2760

cagcttgctg cccagctgca ggatattgcc cactctgccc tggtgggcgg tcagatccat     2820

catgtagccc tcgtgggtgt ggaactggtc cttcaccact tccacgtcgt tgctgatctc     2880

gccctgggcc tgcagggtgt cctcggcgct cagcagccag gacagcactt cctccagggc     2940

ggtctggtat ctgtccaggt tcacttcgct ctccatcagg ctgctgccga agctcttgtc     3000

ctcgggggcc tccaggtgct ggctggggaa ggggcttctg gtggggtcgg aggtggtcac     3060

gtaggcggcc tgggtgtagg cgtagctctt gaatctgggc ttggggctgc tggttctctc     3120

atagccctgg gccaggctca ctgtgatctg ctggctgtag tgcatctggt ggtgcagctg     3180

gaagtgctcc tccttggtca ctttgggggg cctgggcagc atttccactt cctggatggc     3240

ctcgatggac acctgctggg gcagcacctg gaacaggctg gtaatgtaca tgaggatgct     3300

tttcttgtcg gggtaggtgg tgtccacgtc ctcggggtcc agcagcttct cgatgcccag     3360

ctggtatctg gcgatgttga aggcgtgctc cagtctctgg gtggcgctct gctgacacac     3420

cacgctgttc cagtcgaaca ggtcgggtct gtggctgtgg atcagggcgt tcagggccag     3480

gccgtcgctc caggaggtgg tgaagttgat cacgttcacc tgggggtagt ttctggtgct     3540

ctgcctcacc cagctcagca ggatcttctc gctgttggtc tgctgcaggc cggccatgat     3600

gttcttcatc acgttcttca cctgccagtg caggatgatg ttccagatca ggcccagggt     3660

cagcttgtgg ttgccgtcca cgatgtcggt gctgccgatg ttcaccaggt ccacgttgtt     3720

gttctgcagc actctcaggg ccttgttcac gttgttcagg gcgtgcactc tggtgctgcc     3780

cttctccttg ggcagcttct ggccggtcag gccctccagc aggtccagca gtctcctgcc     3840

atcctgcagg tcgctgaaca ggttctcgat gtgctgcttg ccgaacttgc tgaactgggc     3900

gttcacccac ttggtgaagg ttttcttctg cacgtcctct ctctcgtagc agtcctccac     3960

ttcctcccac caaagcat                                                   3978


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
ggaagtggag gactgctacg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
gagaggacgt gcagaagaaa                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
ggacgtgcag aagaaaacct                                                   20


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
acgcccagtt cagcaagttc ggc                                               23


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
cagttcagca agttcggcaa gcag                                              24


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
gcaagcagca catcgagaac                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
agaacctgtt cagcgacctg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
gctgaacagg ttctcgatgt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
aggtcgctga acaggttctc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
caggtcgctg aacaggttct                                                   20


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
cctgctggag ggcctgaccg g                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
cagaagctgc ccaaggagaa                                                   20


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
accagagtgc acgccctgaa ca                                                22


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
cctgagagtg ctgcagaaca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
gggccttgtt cacgttgttc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
aacaacaacg tggacctggt                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
tgttctgcag cactctcagg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
accaggtcca cgttgttgtt                                                   20


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
ggcagcaccg acatcgtgga cgg                                               23


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
ctggaacatc atcctgcact g                                                 21


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
tgccagtgca ggatgatgtt                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
atggccggcc tgcagcagac                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
ggccggcctg cagcagacca                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
cagaccaaca gcgagaagat                                                   20


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
agaccaacag cgagaaga                                                     18


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
accaacagcg agaagatcct                                                   20


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
gctgagctgg gtgaggcaga gca                                               23


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
agcaggatct tctcgctgtt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
cccagctcag caggatcttc                                                   20


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
tgaggcagag caccagaaac tacc                                              24


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
aggaggtggt gaagttgat                                                    19


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
caggaggtgg tgaagttgat                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
ccaggaggtg gtgaagttga                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63
gccatccagg aagtggaaat                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
ccatccagga agtggaaatg                                                   20


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65
ccaaagtgac caaggaggag cact                                              24


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66
caccaccaga tgcactacag                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67
caccaccaga tgcactacag                                                   20


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68
gcagatcaca gtgagcctgg ccca                                              24


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69
gtgatctgct ggctgtagtg                                                   20


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70
tgtgatctgc tggctgta                                                     18


<210>  71
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71
cagggctatg agagaaccag cagc                                              24


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72
gctcttgaat ctgggcttgg                                                   20


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73
gtaggcgtag ctcttgaatc tg                                                22


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74
agcgaagtga acctggacag                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75
gcgaagtgaa cctggacaga                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76
ctggaggaag tgctgtcctg                                                   20


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77
gccgaggaca ccctgcaggc c                                                 21


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78
atcagcaacg acgtggaagt                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79
acgtggaagt ggtgaaggac                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80
tccacgtcgt tgctgatctc                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81
acttccacgt cgttgctgat                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82
ttcaccactt ccacgtcgtt                                                   20


<210>  83
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83
ggaccagttc cacacccacg agg                                               23


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84
ccacgagggc tacatgatgg                                                   20


<210>  85
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85
tgatggatct gaccgcccac cagg                                              24


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86
ggcggtcaga tccatcatgt                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87
cagggcagag tgggcaatat                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88
gcaggatatt gcccactctg                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89
cggcaccggc aagctgagcg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90
tcatctgctc ctgcacttcg                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91
agatgggagt gcctgagagt                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92
actctcaggc actcccatct                                                   20


<210>  93
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93
cagcatggag aagcagagca acctg                                             25


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94
tggagaagca gagcaacctg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95
caggttgctc tgcttctcca                                                   20


<210>  96
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96
agtgctgatg gacctgcaga acca                                              24


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97
ctgatggacc tgcagaacca                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98
gacctgcaga accagaagct                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99
tgaaggagct gaacgactgg                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100
agcttctggt tctgcaggtc                                                   20


<210>  101
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101
tggctgacca agaccgagga gcg                                               23


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102
tcttggtcag ccagtcgttc                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103
agcggaccag aaagatggag                                                   20


<210>  104
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  104
gcggaccaga aagatggagg aggagcc                                           27


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  105
cggaccagaa agatggagga                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106
gggctcctcc tccatctttc                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107
gggccccgac ctggaggacc                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  108
tgctgcacct gtctcttcag                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  109
ctgctgcacc tgtctcttca                                                   20


<210>  110
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110
cctcctgcag cactttgtg                                                    19


<210>  111
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111
gtcctcctgc agcactttg                                                    19


<210>  112
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  112
ctggaagagc agctgaaag                                                    19


<210>  113
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113
tgggcgacag atgggccaat attt                                              24


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  114
ggcgacagat gggccaatat                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  115
cctcggtcca cctacaaata                                                   20


<210>  116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  116
gcctgaccac catcggcgcc a                                                 21


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  117
acaaaggaga ccgccatcag                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  118
ctgatggcgg tctcctttgt                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  119
gtgcccaccc accgcctgct                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  120
tggacctgga gaagttcctg                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  121
ccgaggccga aaccaccgcc                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  122
gaaaggagag gctgctggag                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  123
ccagcagcct ctcctttcta                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  124
ctccagcagc ctctcctttc                                                   20


<210>  125
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  125
gcaagggcgt gaaagagctg atgaag                                            26


<210>  126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  126
tgaagcagtg gcaggatctg                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  127
tcgaggccca caccgacgtg                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  128
gatttcgccc tgcagatcct                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  129
gctgttctcg tccaggttgt                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  130
ctgcggaaga agagcctgaa                                                   20


<210>  131
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  131
tccggagcca cctggaagcc a                                                 21


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  132
ctgaaggacg acgagctgag                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  133
ctcagctcgt cgtccttcag                                                   20


<210>  134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  134
acgacgtgca ccgggccttc a                                                 21


<210>  135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  135
aaccaaggaa cccgtgatca                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  136
ggagacagtg cggatcttcc                                                   20


<210>  137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  137
cctgaccgag cagcccctgg a                                                 21


<210>  138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  138
ctgctcggtc aggaagatcc                                                   20


<210>  139
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  139
agctgtacca ggagcccaga gagct                                             25


<210>  140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  140
tggtacagct tctccagtcc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  141
gagagagccc agaacgtgac                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  142
tgaccaggct gctgagaaag                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  143
gtcacgttct gggctctctc                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  144
caggccgagg aagtgaatac                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  145
tgaataccga gtgggagaag                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  146
aataccgagt gggagaagct                                                   20


<210>  147
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  147
agtgggagaa gctgaatctg caca                                              24


<210>  148
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  148
tgaatctgca cagcgccgac tgg                                               23


<210>  149
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  149
ggcagagaaa gatcgacgag accctgg                                           27


<210>  150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  150
aagatcgacg agaccctgga                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  151
ggtctcgtcg atctttctct                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  152
agggtctcgt cgatctttct                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  153
tccagggtct cgtcgatctt                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  154
tcctgcagtt cctggagtct                                                   20


<210>  155
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  155
agccaccgac gagctggacc t                                                 21


<210>  156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  156
ttcctgcagt tcctggagtc                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  157
gagacaggcc gaagtgatca                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  158
agacaggccg aagtgatcaa                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  159
acaggccgaa gtgatcaagg                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  160
ggcagctggc agcctgtggg                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  161
ccttgatcac ttcggcctgt                                                   20


<210>  162
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  162
gcagctggca gcctgtggg                                                    19


<210>  163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  163
gatcgactcc ctgcaggatc                                                   20


<210>  164
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  164
cctggagaaa gtgaaggccc tgcgg                                             25


<210>  165
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  165
gccttcactt tctccaggtg                                                   20


<210>  166
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  166
ggccttcact ttctccaggt                                                   20


<210>  167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  167
agaatgtgag ccacgtgaac                                                   20


<210>  168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  168
gaatgtgagc cacgtgaacg                                                   20


<210>  169
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  169
cacgtggctc acattctcct                                                   20


<210>  170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  170
tcacgtggct cacattctcc                                                   20


<210>  171
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  171
gccagacagc tgaccaccct ggg                                               23


<210>  172
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  172
ctgagcccct acaacctgag                                                   20


<210>  173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  173
acaacctgag cacactggag                                                   20


<210>  174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  174
ctccagtgtg ctcaggttgt                                                   20


<210>  175
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  175
gatcctccag tgtgctcagg                                                   20


<210>  176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  176
agatcctcca gtgtgctcag                                                   20


<210>  177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  177
aactgctgca ggtggccgtg g                                                 21


<210>  178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  178
tgctgcaggt ggccgtggag g                                                 21


<210>  179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  179
cagctgcctc actctatcct                                                   20


<210>  180
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  180
gtgcagctgc ctcactctat                                                   20


<210>  181
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  181
cccaacaaag tgccctacta                                                   20


<210>  182
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  182
caaagtgccc tactacatca ac                                                22


<210>  183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  183
catcaaccac gagacccaga                                                   20


<210>  184
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  184
catcaaccac gagacccaga ccac                                              24


<210>  185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  185
atcaaccacg agacccagac                                                   20


<210>  186
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  186
tcaaccacga gacccagac                                                    19


<210>  187
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  187
tcaaccacga gacccagacc ac                                                22


<210>  188
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  188
accgagctgt atcagagcct ggcc                                              24


<210>  189
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  189
ccgagctgta tcagagcctg gccg                                              24


<210>  190
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  190
atacagctcg gtcatcttag g                                                 21


<210>  191
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  191
gatacagctc ggtcatctta gg                                                22


<210>  192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  192
acctgaacaa tgtgcggttc                                                   20


<210>  193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  193
aaccgcacat tgttcaggtc                                                   20


<210>  194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  194
gaaccgcaca ttgttcaggt                                                   20


<210>  195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  195
tgaaccgcac attgttcagg                                                   20


<210>  196
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  196
tgcggagact gcagaaggcc ct                                                22


<210>  197
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  197
tcaggctcag cagatccag                                                    19


<210>  198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  198
ctggaccagc acaacctgaa                                                   20


<210>  199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  199
tggaccagca caacctgaag                                                   20


<210>  200
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  200
aagcagaatg accagcccat                                                   20


<210>  201
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  201
cagcccatgg acatcctgca gatca                                             25


<210>  202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  202
actgcctgac cacaatctac                                                   20


<210>  203
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  203
tgcctgacca caatctacga ccggc                                             25


<210>  204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  204
caatctacga ccggctggaa                                                   20


<210>  205
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  205
atctacgacc ggctggaac                                                    19


<210>  206
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  206
acaggagcac aacaacctgg tgaa                                              24


<210>  207
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  207
ttccagccgg tcgtagattg                                                   20


<210>  208
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  208
caggagcaca acaacctggt gaatgtg                                           27


<210>  209
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  209
gttccagccg gtcgtagatt                                                   20


<210>  210
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  210
caggttgttg tgctcctgtt                                                   20


<210>  211
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  211
gcccctgtgc gtggacatgt gc                                                22


<210>  212
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  212
cgtggacatg tgcctgaatt                                                   20


<210>  213
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  213
cctgaattgg ctgctgaacg                                                   20


<210>  214
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  214
ctgaattggc tgctgaacgt                                                   20


<210>  215
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  215
acgtgtacga caccggcagg acc                                               23


<210>  216
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  216
cgttcagcag ccaattcagg                                                   20


<210>  217
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  217
cacgttcagc agccaattc                                                    19


<210>  218
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  218
acacgttcag cagccaattc                                                   20


<210>  219
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  219
gtacacgttc agcagccaat                                                   20


<210>  220
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  220
cggcagaatc cgcgtgctga gc                                                22


<210>  221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  221
atgatgccgg tcttgaagct                                                   20


<210>  222
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  222
cttgcacagg ctgatgatgc                                                   20


<210>  223
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  223
gctgcacgat agcatccaga                                                   20


<210>  224
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  224
gcggcagcaa catcgagccc t                                                 21


<210>  225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  225
gtgaggagct gcttccagtt                                                   20


<210>  226
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  226
aactggaagc agctcctcac                                                   20


<210>  227
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  227
gcccgagatc gaggccgccc                                                   20


<210>  228
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  228
ccctgttcct ggactggatg                                                   20


<210>  229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  229
gcctcatcca gtccaggaac                                                   20


<210>  230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  230
gccgccgaga ccgccaagca                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  231
accaggccaa gtgcaatatc                                                   20


<210>  232
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  232
cccatcatcg gcttccggta ca                                                22


<210>  233
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  233
caggagcctg aagcacttca                                                   20


<210>  234
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  234
tgaagtgctt caggctcctg                                                   20


<210>  235
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  235
actacgacat ctgccagagc tgctt                                             25


<210>  236
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  236
acatctgcca gagctgcttt                                                   20


<210>  237
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  237
ctggcagatg tcgtagttga ag                                                22


<210>  238
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  238
ccggcgagga tgtgagagac ttcgc                                             25


<210>  239
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  239
tcagcacttt ggcgaagtct                                                   20


<210>  240
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  240
cttggcaaag taccgcttgg                                                   20


<210>  241
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  241
ggaaccccta gtgatggagt t                                                 21


<210>  242
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  242
aacatgctac gcagagaggg agtgg                                             25


<210>  243
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  243
cggcctcagt gagcga                                                       16


<210>  244
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  244
catgagacaa ggaaccccta gtgatggag                                         29


