                         SEQUENCE LISTING

<110>  The Institute of Cancer Research: Royal Cancer Hospital
 
<120>  Means and methods for treating cancer

<130>  P275832WO

<150>  GB1909135.4
<151>  2019-06-25

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Arg Gln Asn Leu Val Ala Leu Thr Val Thr Thr Leu Leu Gly 
1               5                   10                  15      


Val Ala Val Gly Gly Phe Val Leu Trp Lys Gly Ile Gln Arg Arg Arg 
            20                  25                  30          


Arg Ser Lys Thr Ser Pro Val Thr Gln Gln Pro Gln Gln Lys Val Leu 
        35                  40                  45              


Gly Ser Arg Glu Leu Pro Pro Pro Glu Asp Asp Gln Leu His Ser Ser 
    50                  55                  60                  


Ala Pro Arg Ser Ser Trp Lys Glu Arg Ile Leu Lys Ala Lys Val Val 
65                  70                  75                  80  


Thr Val Ser Gln Glu Ala Glu Trp Asp Gln Ile Glu Pro Leu Leu Arg 
                85                  90                  95      


Ser Glu Leu Glu Asp Phe Pro Val Leu Gly Ile Asp Cys Glu Trp Val 
            100                 105                 110         


Asn Leu Glu Gly Lys Ala Ser Pro Leu Ser Leu Leu Gln Met Ala Ser 
        115                 120                 125             


Pro Ser Gly Leu Cys Val Leu Val Arg Leu Pro Lys Leu Ile Cys Gly 
    130                 135                 140                 


Gly Lys Thr Leu Pro Arg Thr Leu Leu Asp Ile Leu Ala Asp Gly Thr 
145                 150                 155                 160 


Ile Leu Lys Val Gly Val Gly Cys Ser Glu Asp Ala Ser Lys Leu Leu 
                165                 170                 175     


Gln Asp Tyr Gly Leu Val Val Arg Gly Cys Leu Asp Leu Arg Tyr Leu 
            180                 185                 190         


Ala Met Arg Gln Arg Asn Asn Leu Leu Cys Asn Gly Leu Ser Leu Lys 
        195                 200                 205             


Ser Leu Ala Glu Thr Val Leu Asn Phe Pro Leu Asp Lys Ser Leu Leu 
    210                 215                 220                 


Leu Arg Cys Ser Asn Trp Asp Ala Glu Thr Leu Thr Glu Asp Gln Val 
225                 230                 235                 240 


Ile Tyr Ala Ala Arg Asp Ala Gln Ile Ser Val Ala Leu Phe Leu His 
                245                 250                 255     


Leu Leu Gly Tyr Pro Phe Ser Arg Asn Ser Pro Gly Glu Lys Asn Asp 
            260                 265                 270         


Asp His Ser Ser Trp Arg Lys Val Leu Glu Lys Cys Gln Gly Val Val 
        275                 280                 285             


Asp Ile Pro Phe Arg Ser Lys Gly Met Ser Arg Leu Gly Glu Glu Val 
    290                 295                 300                 


Asn Gly Glu Ala Thr Glu Ser Gln Gln Lys Pro Arg Asn Lys Lys Ser 
305                 310                 315                 320 


Lys Met Asp Gly Met Val Pro Gly Asn His Gln Gly Arg Asp Pro Arg 
                325                 330                 335     


Lys His Lys Arg Lys Pro Leu Gly Val Gly Tyr Ser Ala Arg Lys Ser 
            340                 345                 350         


Pro Leu Tyr Asp Asn Cys Phe Leu His Ala Pro Asp Gly Gln Pro Leu 
        355                 360                 365             


Cys Thr Cys Asp Arg Arg Lys Ala Gln Trp Tyr Leu Asp Lys Gly Ile 
    370                 375                 380                 


Gly Glu Leu Val Ser Glu Glu Pro Phe Val Val Lys Leu Arg Phe Glu 
385                 390                 395                 400 


Pro Ala Gly Arg Pro Glu Ser Pro Gly Asp Tyr Tyr Leu Met Val Lys 
                405                 410                 415     


Glu Asn Leu Cys Val Val Cys Gly Lys Arg Asp Ser Tyr Ile Arg Lys 
            420                 425                 430         


Asn Val Ile Pro His Glu Tyr Arg Lys His Phe Pro Ile Glu Met Lys 
        435                 440                 445             


Asp His Asn Ser His Asp Val Leu Leu Leu Cys Thr Ser Cys His Ala 
    450                 455                 460                 


Ile Ser Asn Tyr Tyr Asp Asn His Leu Lys Gln Gln Leu Ala Lys Glu 
465                 470                 475                 480 


Phe Gln Ala Pro Ile Gly Ser Glu Glu Gly Leu Arg Leu Leu Glu Asp 
                485                 490                 495     


Pro Glu Arg Arg Gln Val Arg Ser Gly Ala Arg Ala Leu Leu Asn Ala 
            500                 505                 510         


Glu Ser Leu Pro Thr Gln Arg Lys Glu Glu Leu Leu Gln Ala Leu Arg 
        515                 520                 525             


Glu Phe Tyr Asn Thr Asp Val Val Thr Glu Glu Met Leu Gln Glu Ala 
    530                 535                 540                 


Ala Ser Leu Glu Thr Arg Ile Ser Asn Glu Asn Tyr Val Pro His Gly 
545                 550                 555                 560 


Leu Lys Val Val Gln Cys His Ser Gln Gly Gly Leu Arg Ser Leu Met 
                565                 570                 575     


Gln Leu Glu Ser Arg Trp Arg Gln His Phe Leu Asp Ser Met Gln Pro 
            580                 585                 590         


Lys His Leu Pro Gln Gln Trp Ser Val Asp His Asn His Gln Lys Leu 
        595                 600                 605             


Leu Arg Lys Phe Gly Glu Asp Leu Pro Ile Gln Leu Ser 
    610                 615                 620     


<210>  2
<211>  5032
<212>  DNA
<213>  Homo sapiens

<400>  2
aacggaagtg gttacggccc tagtgaatcc gggtgggtgc gcgcaggcgg ccgcacaggt       60

tccaggtctt taacgtgagc ccgctgcagg tgtgcggccc agtccgagac agcagatgag      120

gagactgtcc ttcctgtttc gcagatgagg aaactgaggc ttagagaagt ttggcaaatt      180

ggctaagttc ctacagctaa ttgtgggatt agtgatatgc ttttctaaag agtagaaaag      240

tcgaagatgt ctagacagaa cttagtggct ttgacagtga ctacccttct gggtgtggct      300

gtaggggggt ttgtcctctg gaaaggcatc cagcgccgcc gaaggagtaa aacgagtcct      360

gtgacccaac agccacagca gaaagtgctg ggcagtagag agctgccccc tccagaagat      420

gatcagctgc actccagtgc ccccagatcc tcgtggaagg aacggatcct taaagcaaag      480

gtggtgacgg tgtctcagga ggcagagtgg gatcaaatcg agcccttgct tagaagtgaa      540

ttagaagatt ttccagtact tggaattgac tgtgagtggg taaatttgga aggcaaagcc      600

agccctctgt cacttctaca aatggcctcc ccaagtggcc tgtgtgtctt ggttcgcctg      660

cccaagctaa tctgtggagg aaaaacacta ccaagaacgt tattggatat tttggcagat      720

ggcaccattt tgaaagttgg agtgggatgc tcagaagatg ccagcaagct tctgcaggat      780

tatggcctcg ttgttagggg gtgcctggac ctccgatacc tagccatgcg gcagagaaac      840

aatttgctct gtaatgggct tagcctgaag tccctcgctg agactgtttt gaactttccc      900

cttgacaagt cccttctact tcgttgcagc aactgggatg ctgagactct cacagaggac      960

caggtaattt atgctgccag ggatgcccag atttcagtgg ctctctttct tcatcttctt     1020

ggataccctt tctctaggaa ttcacctgga gaaaaaaacg atgaccacag tagctggaga     1080

aaagtcttgg aaaaatgcca gggtgtggtc gacatcccat ttcgaagcaa aggaatgagc     1140

agattgggag aagaggttaa tggggaagca acagaatctc agcagaagcc aagaaataag     1200

aagtctaaga tggatgggat ggtgccaggc aaccaccaag ggagagaccc cagaaaacat     1260

aaaagaaagc ctctgggggt gggctattct gccagaaaat cacctcttta tgataactgc     1320

tttctccatg ctcctgatgg acagcccctc tgcacttgtg atagaagaaa agctcagtgg     1380

tacctggaca aaggcattgg tgagctggtg agtgaagagc cctttgtggt gaagctacgg     1440

tttgaacctg caggaaggcc cgaatctcct ggagactatt acttgatggt taaagagaac     1500

ctgtgtgtag tgtgtggcaa gagagactcc tacattcgga agaacgtgat tccacatgag     1560

taccggaagc acttccccat cgagatgaag gaccacaact cccacgatgt gctgctgctc     1620

tgcacctcct gccatgccat ttccaactac tatgacaacc atctgaagca gcagctggcc     1680

aaggagttcc aggcccccat cggctctgag gagggcttgc gcctgctgga agatcctgag     1740

cgccggcagg tgcgttctgg ggccagggcc ctgctcaacg cggagagcct gcctactcag     1800

cgaaaggagg agctgctgca agcactcaga gagttttata acacagacgt ggtcacagag     1860

gagatgcttc aagaggctgc cagcctggag accagaatct ccaatgaaaa ctatgttcct     1920

cacgggctga aggtggtgca gtgtcacagc cagggtggcc tgcgctccct catgcagctg     1980

gagagccgct ggcgtcagca cttcctggac tccatgcagc ccaagcacct gccccagcag     2040

tggtcagtgg accacaacca tcagaagctg ctccggaaat tcggggaaga tcttcccatc     2100

cagctgtctt gatagctgct ttcctcccag ttaggacaag tgggaagctg gagccaaggt     2160

tgaagagtca cctcttccca ttttagtaca tcattaattg tcaaagcctg tgtgacacaa     2220

ctcagaatac taacctagac taatcccagg atgcttctgc tggagcaaag atattgtttg     2280

aaggagagtt tatggttttg gattttaaac gggcagggtc ttttttcctc tcatttttgt     2340

ggacaagaga ggccttcgcc tttattttta ctctccctct tctgctgtcc ctgtgcagag     2400

gaaaaatgaa gaattctccc agaagtgact tgtcaagact taaaaaaaat gtttttaatg     2460

catttcttcc ttgtctagtg cctcggttta tctctaacag gggctgtcca gtatatcggt     2520

cctgttagga ggggagaaaa agttcttcca aaggctggag aagtgaacaa ggagtcaaat     2580

ttattttccc aattcaactt cataattatc atttctttgg cttcatgctc tcccgtaact     2640

catgtggttg ggatccatcc catctgggtc acttcagtct acttcacgta cttgaaaagg     2700

ctttccttta cacttccagg accaaacagc aacttcctgc cacacacttc caccctatca     2760

ctgggagaaa tccttttctg gacatgagcc tttgacctgg gtggggcaga aagaaccaca     2820

aactccatct cccaatagaa ctttgaaatt cactcagctt ttcctttcat gctgtttgtt     2880

gcctgcttgt tgcactcctc ctgccccaga actgcaagat ttttagcttc acccctttct     2940

gagagtaatg ttatctttta tcagaatcag tatcagttcc cctgtattct gtgcttcatc     3000

gaatttgcaa gactgacctc ttttaagcat ttaattcact cccagagtca tctggtcagg     3060

ttgcaatatg aggacttctc tgtctcctct gaagcctggg acactgagct tacttaatac     3120

attagatgtt caaaagagga gcgttgtttc atctttcaaa atgttaggcc attactttga     3180

gtataaaatc gacttattaa tgattagtaa tttttctaaa gtattgggaa aactttctta     3240

ttttataaga tcttaacaag cttaaaaaag aattttatga ccagaatcca acaagagctc     3300

tattttggaa ttgtgcccaa gttggtgatg tttactctaa aattaataat aaaactactt     3360

gtaagcacaa ggctcactgg atgtaaatgt aaaacttcgc gactttataa aactggcatt     3420

cctaggggag gggctattta tcctacaggt ccctgcctcc tggcagtgcc atggtatgtg     3480

tgcatggata taccagacac agtcaccatc ggccatcagt agcagcccat gaacccacgt     3540

gcacatcctg catcttgctc ttctgaccct tcattcccac ttgtcttcag gcaggcattt     3600

ctgggatcta aactagaaat ccttgaaaac aaatagtacc agccactttg aggaatgtgc     3660

attcactgta gtgggttatt atggggtctc tgcctcctgg ctgtgttatg cggagcccag     3720

gagtggagga gagccgtgga aatagacagg gagaggctgg tacttgggtt gtggtaatag     3780

tcaggcttgc cacaagaggg cactcataga tttgttttta tattcattct tgagaaaaaa     3840

gcaactggtt actgaacgta actcatgact tatgtttcaa attttgcata gctgatttta     3900

agtcattttg atagctttgc aagaaaaatt tttcctttga aacaagggag tagggctgtt     3960

tcattttctt tccttctaat cctcatgcca agaggtgaga aacacttaag gtcatttaag     4020

gtgctaggga aagggttttc ccatggagct ttctgtgagg cgcagtaaaa tagagccagc     4080

agcaaagtag aggaaaaagc cagactgcgt cacacaagat ttctcatcct tttcaggaga     4140

gagtcactgt gtagatttga atcttttttc tttgagtctg ctttgaactt tagcaggctt     4200

ttcctaagac tgacaattgt cgtcttaaat cagagatttg agggtagact tattttatgg     4260

caaatgtcta tttttctgat ataaaagtaa caatgctcat tacagaagaa tctaaacaaa     4320

gaataaaaat tagccatctt ctctccatct aaaacagagc taaactttgc tgatatgttt     4380

atgaatttcc tttcagtatt aaaaagtgca tataaggtgt atatttacac aaaattgaag     4440

gtcatacata gatacaggtt ggtatcctaa ctttaccctc tcactgatta acatggtatc     4500

acgagtaact tcctatgttt ttaaatcttt gaaaatagat ttctagtggt tctaccttat     4560

ccatccccac actgttgaaa attttggttg tttcagatac ttttattatc aatgatgatg     4620

tgataaagtt tcttgtatat atctctttgg ctctatcttt ggtaatttct taagaatgga     4680

atcttagaat tggactgtga agagggggat tcacattgct ggggctaagt acaaattgac     4740

atcacctttt aggaatgaaa tgcttctctt tgacccttta gctccagtgt cccagcatag     4800

tcactgggct tcataggagt agcagtgaga ggacagtgtc acagcaaggg cctctctgca     4860

tgctccctga tcattgtgtt tgcaggttca gcatttcttc ttgagtcctt cccttcttcc     4920

aaccttattg cctcatttcc cccttgtagt caatgttttt tggaaacact gtttatttta     4980

aaataaaaat gtaaaaaaaa ggtaaaaaaa taaaatttta aattttaaaa ta             5032


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siEXD2

<400>  3
cagaggacca gguaauuua                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siEXD2

<400>  4
gaacaaggag ucaaauuua                                                    19


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA oligo

<400>  5
gtctaattca cttctaagca a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA oligo

<400>  6
gacttggaat tgactgtgag t                                                 21


<210>  7
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN

<400>  7
aggaggcaga gtgggatcaa atcgagccct tgcttagatc tgaattagaa gattttccag       60

tacttggtat cgcttgtgcg tgggtaagtt aaaaagcaaa agttaaaaaa                 110


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting luciferase

<400>  8
cgtacgcgga atacttcga                                                    19


