﻿                         序列表

<110>  科济生物医药（上海）有限公司

<120>  抗移植反应的细胞和方法

<130>  FD00251PCT

<141>  2020-06-29

<150>  201910576425X
<151>  2019-06-28

<150>  201910809425X
<151>  2019-08-29

<160>  25

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  125
<212>  PRT
<213>  Artificial Sequence

<400>  1
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Ala Gln Lys Leu 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr Leu Tyr Trp Phe Phe 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<400>  2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  3
<211>  68
<212>  PRT
<213>  Artificial Sequence

<400>  3
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          
Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              
Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  
Ala Tyr Arg Ser 
65              

<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<400>  4
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210>  5
<211>  494
<212>  PRT
<213>  Artificial Sequence

<400>  5
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              
Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  
Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His 
65                  70                  75                  80  
Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                85                  90                  95      
Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr 
        115                 120                 125             
Leu Tyr Trp Phe Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser 
            180                 185                 190         
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             
Ile Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro 
                245                 250                 255     
Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro 
            260                 265                 270         
Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             
Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 
Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         
Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             
Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    370                 375                 380                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 

<210>  6
<211>  489
<212>  PRT
<213>  Artificial Sequence

<400>  6
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              
Thr Phe Gly Gly Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe 
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Lys Val Arg Pro Phe Trp Gly Thr Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 
Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             
Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Tyr Phe Asn Pro Pro Glu Tyr Thr Phe Gly 
                245                 250                 255     
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     
Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 
Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 

<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<400>  7
agagtctctc agctggtaca                                                    20

<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<400>  8
gagtagcgcg agcacagcta                                                    20

<210>  9
<211>  751
<212>  PRT
<213>  Artificial Sequence

<400>  9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              
Thr Phe Gly Gly Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe 
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Lys Val Arg Pro Phe Trp Gly Thr Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 
Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             
Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Tyr Phe Asn Pro Pro Glu Tyr Thr Phe Gly 
                245                 250                 255     
Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        275                 280                 285             
Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
    290                 295                 300                 
Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Ala 
305                 310                 315                 320 
Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Tyr Asp Ser 
                325                 330                 335     
Glu Thr His Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr 
            340                 345                 350         
Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 
        355                 360                 365             
Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Asp Phe Asp 
    370                 375                 380                 
Val Gly Thr Leu Tyr Trp Phe Phe Asp Val Trp Gly Gln Gly Thr Thr 
385                 390                 395                 400 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     
Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            420                 425                 430         
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn 
        435                 440                 445             
Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    450                 455                 460                 
Lys Leu Leu Ile Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser 
465                 470                 475                 480 
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                485                 490                 495     
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr 
            500                 505                 510         
Gly Thr Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr 
        515                 520                 525             
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    530                 535                 540                 
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
545                 550                 555                 560 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                565                 570                 575     
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            580                 585                 590         
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        595                 600                 605             
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    610                 615                 620                 
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
625                 630                 635                 640 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                645                 650                 655     
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            660                 665                 670         
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
        675                 680                 685             
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    690                 695                 700                 
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
705                 710                 715                 720 
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                725                 730                 735     
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 750     

<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  10
Ser Tyr Trp Met Asn 
1               5   

<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<400>  11
Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      
Gly 
    

<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  12
Gly Gly Tyr Asp Phe Asp Val Gly Thr Leu Tyr Trp Phe Phe Asp Val 
1               5                   10                  15      

<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<400>  13
Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      

<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  14
Asn Ala Lys Thr Leu Ala Glu 
1               5           

<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  15
Gln His His Tyr Gly Thr Pro Arg Thr 
1               5                   

<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  16
Gly Asn Ala Met Ser 
1               5   

<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<400>  17
Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  18
Val Arg Pro Phe Trp Gly Thr Phe Asp Tyr 
1               5                   10  

<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  19
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          

<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  20
Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  21
Gln Gln Tyr Phe Asn Pro Pro Glu Tyr Thr 
1               5                   10  

<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<400>  22
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Asn 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Val Arg Pro Phe Trp Gly Thr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  23
<211>  110
<212>  PRT
<213>  Artificial Sequence

<400>  23
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Phe Asn Pro Pro 
                85                  90                  95      
Glu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 

<210>  24
<211>  750
<212>  PRT
<213>  Artificial Sequence

<400>  24
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              
Thr Phe Gly Gly Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe 
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Lys Val Arg Pro Phe Trp Gly Thr Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 
Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             
Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Tyr Phe Asn Pro Pro Glu Tyr Thr Phe Gly 
                245                 250                 255     
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     
Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 
Leu His Met Gln Ala Leu Pro Pro Arg Val Lys Gln Thr Leu Asn Phe 
                485                 490                 495     
Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met 
            500                 505                 510         
Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
        515                 520                 525             
Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
    530                 535                 540                 
Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
545                 550                 555                 560 
Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
                565                 570                 575     
Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
            580                 585                 590         
His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
        595                 600                 605             
Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
    610                 615                 620                 
Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
625                 630                 635                 640 
Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
                645                 650                 655     
Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
            660                 665                 670         
Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
        675                 680                 685             
Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
    690                 695                 700                 
Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
705                 710                 715                 720 
Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                725                 730                 735     
Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            740                 745                 750 

<210>  25
<211>  755
<212>  PRT
<213>  Artificial Sequence

<400>  25
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              
Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  
Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His 
65                  70                  75                  80  
Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                85                  90                  95      
Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr 
        115                 120                 125             
Leu Tyr Trp Phe Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser 
            180                 185                 190         
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             
Ile Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro 
                245                 250                 255     
Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro 
            260                 265                 270         
Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             
Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 
Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         
Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             
Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    370                 375                 380                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Val Lys 
                485                 490                 495     
Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
            500                 505                 510         
Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
        515                 520                 525             
Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
    530                 535                 540                 
Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
545                 550                 555                 560 
Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
                565                 570                 575     
Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
            580                 585                 590         
Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
        595                 600                 605             
Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
    610                 615                 620                 
Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
625                 630                 635                 640 
Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
                645                 650                 655     
Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
            660                 665                 670         
Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
        675                 680                 685             
Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
    690                 695                 700                 
Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
705                 710                 715                 720 
Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
                725                 730                 735     
Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
            740                 745                 750         
Leu Tyr Lys 
        755 

