                         б

<110>  ＼(Ϻ)޹˾

<120>  PD-L1׿弰Fcںϵ׺Ӧ

<160>  109

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  126
<212>  PRT
<213>  artificial

<400>  1
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  2
<211>  126
<212>  PRT
<213>  artificial

<400>  2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val His Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Arg Val Ser Met Tyr Thr Tyr Thr Gly 
            20                  25                  30          
Thr Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
        35                  40                  45              
Val Ala Gly Leu Trp Thr Gly Asp Gly Val Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      
Cys Ala Ser Asn Gly Met Cys Gly Gln Tyr Trp Ala Leu Glu Asp Glu 
            100                 105                 110         
Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  3
<211>  128
<212>  PRT
<213>  artificial

<400>  3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  4
<211>  126
<212>  PRT
<213>  artificial

<400>  4
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Val Arg His Tyr 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ser Ile Asp Thr Phe Gly Ile Pro Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Asn Leu 
65                  70                  75                  80  
Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      
Gly Arg Ser Tyr Thr Asn Cys Arg Asp Gly Pro Pro Ser Ala Ser His 
            100                 105                 110         
Tyr Ser His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  5
<211>  122
<212>  PRT
<213>  artificial

<400>  5
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Pro Gly Phe Thr Ser Asn Thr Cys 
            20                  25                  30          
Ala Met Gly Trp Tyr Arg Gln Ala Ala Gly Met Gln Arg Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Lys Tyr Gly Ile Thr Thr Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Lys Asp Lys Ala Glu Asp Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Val Cys Lys 
                85                  90                  95      
Thr Phe Ser Cys Arg Asn Arg Gly Gly Ala Tyr Leu Ala Asp Ala Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  6
<211>  122
<212>  PRT
<213>  artificial

<400>  6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Pro Gly Phe Thr Asp Lys Thr Cys 
            20                  25                  30          
Ala Met Ala Trp Tyr Arg Gln Val Ala Gly Ile Glu Arg Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Thr Leu Gly Thr Thr Asn Tyr Ala Ser Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Val Cys Lys 
                85                  90                  95      
Thr Phe Ser Cys Arg Asn Arg Gly Gly Ser Tyr Leu Pro Asp Thr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  7
<211>  128
<212>  PRT
<213>  artificial

<400>  7
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Leu Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  8
<211>  140
<212>  PRT
<213>  artificial

<400>  8
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Tyr Ala Tyr Ala Thr Tyr 
            20                  25                  30          
Ser Met Ala Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Asn Ser Asp Gly His Thr Thr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Asn Lys Asn Ser Tyr Thr 
65                  70                  75                  80  
Leu Thr Leu Thr Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Ala Ala Thr Ser Gln Leu Gly Phe Trp Ala Gln Lys Leu Trp 
            100                 105                 110         
Glu Ala Ile Arg Asp Gly Thr Trp Ser Pro Ser Thr Thr Asp Phe Gly 
        115                 120                 125             
Phe Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140 

<210>  9
<211>  127
<212>  PRT
<213>  artificial

<400>  9
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ala Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ala Trp Phe Arg Gln Asn Ser Arg Lys Gln Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Asn Arg Asp Gly Asp Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Ser Asp Trp Ser Arg Leu Tyr Lys Ile Tyr Trp Leu Asp Asp Asn 
            100                 105                 110         
Tyr Tyr Val Arg Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         

<210>  10
<211>  124
<212>  PRT
<213>  artificial

<400>  10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Ser Arg Tyr 
            20                  25                  30          
Ser Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Gly Gln Thr Pro Arg Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Gly Gln Ala Leu Leu Trp Ala Ser Leu Arg Gln Thr Ser Tyr Gln 
            100                 105                 110         
Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  11
<211>  119
<212>  PRT
<213>  artificial

<400>  11
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Thr Met Met Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile His Asn Asp Gly Gly Pro Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Trp Tyr Phe Ser Gly Asp Tyr Val Pro Met Thr Gln Gly 
            100                 105                 110         
Thr Gln Val Thr Val Ser Ser 
        115                 

<210>  12
<211>  128
<212>  PRT
<213>  artificial

<400>  12
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Gly Thr Asn 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Gly Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  13
<211>  128
<212>  PRT
<213>  artificial

<400>  13
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Val Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  14
<211>  128
<212>  PRT
<213>  artificial

<400>  14
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Gly Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  15
<211>  128
<212>  PRT
<213>  artificial

<400>  15
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  16
<211>  128
<212>  PRT
<213>  artificial

<400>  16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  17
<211>  128
<212>  PRT
<213>  artificial

<400>  17
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Tyr Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  18
<211>  128
<212>  PRT
<213>  artificial

<400>  18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Thr Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
His Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  19
<211>  128
<212>  PRT
<213>  artificial

<400>  19
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Val Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Leu Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  20
<211>  128
<212>  PRT
<213>  artificial

<400>  20
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  21
<211>  128
<212>  PRT
<213>  artificial

<400>  21
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  22
<211>  128
<212>  PRT
<213>  artificial

<400>  22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  23
<211>  128
<212>  PRT
<213>  artificial

<400>  23
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Ala Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  24
<211>  128
<212>  PRT
<213>  artificial

<400>  24
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Thr Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  25
<211>  128
<212>  PRT
<213>  artificial

<400>  25
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  26
<211>  128
<212>  PRT
<213>  artificial

<400>  26
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Ser Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  27
<211>  128
<212>  PRT
<213>  artificial

<400>  27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Arg Ala Gly Gly Arg Asn Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  28
<211>  128
<212>  PRT
<213>  artificial

<400>  28
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Glu Val Ser Gly Ser Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  29
<211>  128
<212>  PRT
<213>  artificial

<400>  29
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  30
<211>  128
<212>  PRT
<213>  artificial

<400>  30
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Val Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Leu Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  31
<211>  128
<212>  PRT
<213>  artificial

<400>  31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Leu Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  32
<211>  128
<212>  PRT
<213>  artificial

<400>  32
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  33
<211>  128
<212>  PRT
<213>  artificial

<400>  33
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Asn Thr Tyr Ser Thr Lys 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Ala Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  34
<211>  128
<212>  PRT
<213>  artificial

<400>  34
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Val Ser Gly Asn Thr Tyr Ser Thr Asn 
            20                  25                  30          
Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Arg Val Gly Gly Arg Asn Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser 
            100                 105                 110         
Asp Gln Tyr Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             

<210>  35
<211>  126
<212>  PRT
<213>  artificial

<400>  35
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Ala Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  36
<211>  126
<212>  PRT
<213>  artificial

<400>  36
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Ala Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  37
<211>  126
<212>  PRT
<213>  artificial

<400>  37
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  38
<211>  126
<212>  PRT
<213>  artificial

<400>  38
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Ala Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  39
<211>  126
<212>  PRT
<213>  artificial

<400>  39
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  40
<211>  126
<212>  PRT
<213>  artificial

<400>  40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Glu Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  41
<211>  126
<212>  PRT
<213>  artificial

<400>  41
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Gly Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  42
<211>  232
<212>  PRT
<213>  human

<400>  42
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210>  43
<211>  254
<212>  PRT
<213>  artificial

<400>  43
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Glu Gln 
225                 230                 235                 240 
Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
                245                 250                 

<210>  44
<211>  5
<212>  PRT
<213>  artificial

<400>  44
Thr Tyr Ala Met Ser 
1               5   

<210>  45
<211>  5
<212>  PRT
<213>  artificial

<400>  45
Gly Thr Cys Met Ala 
1               5   

<210>  46
<211>  5
<212>  PRT
<213>  artificial

<400>  46
Thr Asn Val Met Gly 
1               5   

<210>  47
<211>  5
<212>  PRT
<213>  artificial

<400>  47
His Tyr Cys Met Gly 
1               5   

<210>  48
<211>  5
<212>  PRT
<213>  artificial

<400>  48
Thr Cys Ala Met Gly 
1               5   

<210>  49
<211>  5
<212>  PRT
<213>  artificial

<400>  49
Thr Cys Ala Met Ala 
1               5   

<210>  50
<211>  5
<212>  PRT
<213>  artificial

<400>  50
Thr Lys Tyr Met Ser 
1               5   

<210>  51
<211>  5
<212>  PRT
<213>  artificial

<400>  51
Thr Tyr Ser Met Ala 
1               5   

<210>  52
<211>  5
<212>  PRT
<213>  artificial

<400>  52
Ala Tyr Tyr Met Ala 
1               5   

<210>  53
<211>  5
<212>  PRT
<213>  artificial

<400>  53
Arg Tyr Ser Val Gly 
1               5   

<210>  54
<211>  5
<212>  PRT
<213>  artificial

<400>  54
Thr Ser Thr Met Met 
1               5   

<210>  55
<211>  5
<212>  PRT
<213>  artificial

<400>  55
Thr Asn Ala Met Gly 
1               5   

<210>  56
<211>  5
<212>  PRT
<213>  artificial

<400>  56
Thr Lys Tyr Met Gly 
1               5   

<210>  57
<211>  5
<212>  PRT
<213>  artificial

<400>  57
Thr Asn Ile Met Gly 
1               5   

<210>  58
<211>  5
<212>  PRT
<213>  artificial

<400>  58
Thr Lys Tyr Met Ala 
1               5   

<210>  59
<211>  5
<212>  PRT
<213>  artificial

<400>  59
Thr Asn Tyr Met Ala 
1               5   

<210>  60
<211>  5
<212>  PRT
<213>  artificial

<400>  60
Ala Tyr Ala Met Ser 
1               5   

<210>  61
<211>  16
<212>  PRT
<213>  artificial

<400>  61
Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys Gly 
1               5                   10                  15      

<210>  62
<211>  17
<212>  PRT
<213>  artificial

<400>  62
Gly Leu Trp Thr Gly Asp Gly Val Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  63
<211>  17
<212>  PRT
<213>  artificial

<400>  63
Ala Ile Leu Ala Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  64
<211>  16
<212>  PRT
<213>  artificial

<400>  64
Ser Ile Asp Thr Phe Gly Ile Pro Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  65
<211>  16
<212>  PRT
<213>  artificial

<400>  65
Ser Ile Ser Lys Tyr Gly Ile Thr Thr Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      

<210>  66
<211>  16
<212>  PRT
<213>  artificial

<400>  66
Ser Ile Ser Thr Leu Gly Thr Thr Asn Tyr Ala Ser Ser Val Lys Gly 
1               5                   10                  15      

<210>  67
<211>  16
<212>  PRT
<213>  artificial

<400>  67
Ala Ile Asn Ser Asp Gly His Thr Thr Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  68
<211>  16
<212>  PRT
<213>  artificial

<400>  68
Ala Ile Asn Arg Asp Gly Asp Thr Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  69
<211>  16
<212>  PRT
<213>  artificial

<400>  69
Gly Gln Thr Pro Arg Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys Asp 
1               5                   10                  15      

<210>  70
<211>  17
<212>  PRT
<213>  artificial

<400>  70
Gly Ile His Asn Asp Gly Gly Pro Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  71
<211>  17
<212>  PRT
<213>  artificial

<400>  71
Ala Ile Leu Gly Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  72
<211>  17
<212>  PRT
<213>  artificial

<400>  72
Ala Ile Leu Ala Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  73
<211>  17
<212>  PRT
<213>  artificial

<400>  73
Ala Ile Leu Ala Gly Gly Arg Asn Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  74
<211>  17
<212>  PRT
<213>  artificial

<400>  74
Ala Ile Leu Ala Gly Gly Arg Asn Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  75
<211>  17
<212>  PRT
<213>  artificial

<400>  75
Ala Ile Leu Val Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  76
<211>  17
<212>  PRT
<213>  artificial

<400>  76
Ala Ile Leu Ala Gly Gly Arg Asn Thr Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  77
<211>  17
<212>  PRT
<213>  artificial

<400>  77
Ala Ile Leu Ala Gly Gly Arg Asn Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  78
<211>  17
<212>  PRT
<213>  artificial

<400>  78
Ala Ile Leu Thr Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  79
<211>  17
<212>  PRT
<213>  artificial

<400>  79
Ala Ile Leu Ala Gly Gly Arg Asn Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  80
<211>  17
<212>  PRT
<213>  artificial

<400>  80
Ala Ile Leu Val Gly Gly Arg Asn Thr Tyr Tyr Ala Asp Pro Val Lys 
1               5                   10                  15      
Gly 
    

<210>  81
<211>  17
<212>  PRT
<213>  artificial

<400>  81
Ala Ile Arg Val Gly Gly Arg Asn Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  82
<211>  16
<212>  PRT
<213>  artificial

<400>  82
Cys Ile Asp Ile Tyr Gly Arg Ala Ser Tyr Thr Asp Pro Val Lys Gly 
1               5                   10                  15      

<210>  83
<211>  19
<212>  PRT
<213>  atificial

<400>  83
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
1               5                   10                  15      
Ser Arg Tyr 
            

<210>  84
<211>  17
<212>  PRT
<213>  artificial

<400>  84
Ser Asn Gly Met Cys Gly Gln Tyr Trp Ala Leu Glu Asp Glu Tyr Lys 
1               5                   10                  15      
Tyr 
    

<210>  85
<211>  20
<212>  PRT
<213>  artificial

<400>  85
Ala Asp Thr Arg Ala Ala Phe Trp Asn Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Ile 
            20  

<210>  86
<211>  19
<212>  PRT
<213>  artificial

<400>  86
Gly Arg Ser Tyr Thr Asn Cys Arg Asp Gly Pro Pro Ser Ala Ser His 
1               5                   10                  15      
Tyr Ser His 
            

<210>  87
<211>  16
<212>  PRT
<213>  artificial

<400>  87
Lys Thr Phe Ser Cys Arg Asn Arg Gly Gly Ala Tyr Leu Ala Asp Ala 
1               5                   10                  15      

<210>  88
<211>  20
<212>  PRT
<213>  artificial

<400>  88
Ala Asp Thr Arg Ala Ala Leu Trp Tyr Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Thr 
            20  

<210>  89
<211>  30
<212>  PRT
<213>  artificial

<400>  89
Ala Thr Ser Gln Leu Gly Phe Trp Ala Gln Lys Leu Trp Glu Ala Ile 
1               5                   10                  15      
Arg Asp Gly Thr Trp Ser Pro Ser Thr Thr Asp Phe Gly Phe 
            20                  25                  30  

<210>  90
<211>  20
<212>  PRT
<213>  artificial

<400>  90
Ala Ser Asp Trp Ser Arg Leu Tyr Lys Ile Tyr Trp Leu Asp Asp Asn 
1               5                   10                  15      
Tyr Tyr Val Arg 
            20  

<210>  91
<211>  17
<212>  PRT
<213>  artificial

<400>  91
Ala Gly Gln Ala Leu Leu Trp Ala Ser Leu Arg Gln Thr Ser Tyr Gln 
1               5                   10                  15      
Phe 
    

<210>  92
<211>  10
<212>  PRT
<213>  artificial

<400>  92
Gly Trp Tyr Phe Ser Gly Asp Tyr Val Pro 
1               5                   10  

<210>  93
<211>  20
<212>  PRT
<213>  artificial

<400>  93
Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Ile 
            20  

<210>  94
<211>  20
<212>  PRT
<213>  artificial

<400>  94
Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser His 
1               5                   10                  15      
Gln Tyr Asn Ile 
            20  

<210>  95
<211>  20
<212>  PRT
<213>  artificial

<400>  95
Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Leu 
            20  

<210>  96
<211>  20
<212>  PRT
<213>  artificial

<400>  96
Ala Asp Thr Arg Ala Ala Phe Trp Ser Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Ile 
            20  

<210>  97
<211>  20
<212>  PRT
<213>  artificial

<400>  97
Ala Asp Thr Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Ser 
            20  

<210>  98
<211>  20
<212>  PRT
<213>  artificial

<400>  98
Ala Asp Ala Arg Ala Ala Phe Trp Tyr Ile Gly Pro Leu Asn Ser Asp 
1               5                   10                  15      
Gln Tyr Asn Ile 
            20  

<210>  99
<211>  19
<212>  PRT
<213>  artificial

<400>  99
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Ala Gly Phe 
1               5                   10                  15      
Ser Arg Tyr 
            

<210>  100
<211>  126
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  100
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Cys Ile Asp Ile Tyr Gly Arg Ala Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  101
<211>  126
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  101
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Ala Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  102
<211>  126
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  102
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Ala Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  103
<211>  126
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  103
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  104
<211>  126
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  104
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  105
<211>  126
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  105
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Gly Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ala Cys Ile Asp Ile Tyr Gly Arg Thr Ser Tyr Thr Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp Val His Glu Gly Phe 
            100                 105                 110         
Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  106
<211>  448
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  106
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  107
<211>  214
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  107
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  108
<211>  220
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  108
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp His Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210>  109
<211>  595
<212>  PRT
<213>  ˹(Artificial Sequence)

<400>  109
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Leu Gly Phe Thr Thr Arg Asn Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
465                 470                 475                 480 
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                485                 490                 495     
Thr Tyr Gly Thr Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys 
            500                 505                 510         
Gly Arg Glu Gly Val Ala Cys Ile Asp Ile Tyr Gly Arg Ala Ser Tyr 
        515                 520                 525             
Thr Asp Pro Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
    530                 535                 540                 
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala 
545                 550                 555                 560 
Val Tyr Tyr Cys Ala Ala Arg Asp Phe Gly Tyr Cys Thr Ala Ser Trp 
                565                 570                 575     
Val His Glu Gly Phe Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            580                 585                 590         
Val Ser Ser 
        595 

