                         б

<110>  Ƽݣ޹˾

<120>  ˮ-״gEͻ弰﷽

<130>  FPCH20160184P

<150>  CN201910575791.3
<151>  2016-06-28

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  546
<212>  PRT
<213>  ˹

<220>
<223>  ͻgEȫ

<400>  1

Met Gly Thr Val Asn Lys Pro Val Val Gly Val Leu Met Gly Phe Gly 
1               5                   10                  15      


Ile Ile Thr Gly Thr Leu Arg Ile Thr Asn Pro Val Arg Ala Ser Val 
            20                  25                  30          


Leu Arg Tyr Asp Asp Phe His Ile Asp Glu Asp Lys Leu Asp Thr Asn 
        35                  40                  45              


Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp 
    50                  55                  60                  


Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro 
65                  70                  75                  80  


Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His 
                85                  90                  95      


Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu 
            100                 105                 110         


Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp 
        115                 120                 125             


Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His 
    130                 135                 140                 


Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly 
145                 150                 155                 160 


Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Met Ile Glu Val Ser Val 
                165                 170                 175     


Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr 
            180                 185                 190         


Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys 
        195                 200                 205             


Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr 
    210                 215                 220                 


Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr 
225                 230                 235                 240 


Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys 
                245                 250                 255     


Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp 
            260                 265                 270         


Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val 
        275                 280                 285             


Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg 
    290                 295                 300                 


Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys 
305                 310                 315                 320 


Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro 
                325                 330                 335     


Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser 
            340                 345                 350         


Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His 
        355                 360                 365             


Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp 
    370                 375                 380                 


Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro 
385                 390                 395                 400 


Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr 
                405                 410                 415     


Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys 
            420                 425                 430         


Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met 
        435                 440                 445             


Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys 
    450                 455                 460                 


Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val 
465                 470                 475                 480 


Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr 
                485                 490                 495     


Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr 
            500                 505                 510         


Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val 
        515                 520                 525             


Asn Pro Gly Thr Ser Pro Leu Leu Arg Tyr Ala Ala Trp Thr Gly Gly 
    530                 535                 540                 


Leu Ala 
545     


<210>  2
<211>  1644
<212>  DNA
<213>  ˹

<220>
<223>  ŻgE

<400>  2
atgggcaccg tcaataagcc cgtggtgggc gtgctgatgg gctttggcat cattaccgga       60

acactccgga tcaccaaccc tgtcagggcc tccgtgctcc ggtatgacga cttccacatc      120

gatgaggaca agctggacac aaactccgtc tacgagccct actaccacag cgaccatgcc      180

gagagctcct gggtgaacag gggcgaaagc tccaggaagg cctacgacca taactccccc      240

tatatctggc ctaggaacga ctacgacggc tttctggaga acgcccatga gcatcatgga      300

gtctataacc agggcagggg catcgacagc ggcgagaggc tgatgcaacc cacccagatg      360

tccgcccagg aggatctggg cgatgacacc ggaatccatg tgatccctac cctgaacggc      420

gatgacaggc acaagatcgt caatgtggac cagcggcagt acggagatgt gttcaagggc      480

gacctgaatc ccaagcccca gggccagagg atgatcgagg tgagcgtgga ggagaaccat      540

ccctttaccc tcagggcccc tatccagcgg atctacggcg tgaggtacac cgagacctgg      600

tccttcctgc cctccctgac atgtacaggc gacgccgccc ccgctattca gcacatctgc      660

ctgaagcaca ccacctgctt tcaggatgtg gtcgtcgacg tggactgcgc cgagaacaca      720

aaagaagacc agctggccga gatctcctac aggttccaag gcaagaagga agctgaccag      780

ccctggatcg tcgtcaacac atccacactc ttcgacgaat tagaactcga tccccctgaa      840

atcgagcccg gagtgctcaa ggtgctgcgg accgagaagc agtacctcgg cgtgtatatc      900

tggaacatgc ggggcagcga cggaacaagc acatacgcta ccttcctggt gacctggaag      960

ggcgacgaaa agaccaggaa ccctacccct gccgtgacac ctcagcctag gggcgccgaa     1020

ttccacatgt ggaactatca ttcccacgtg ttcagcgtcg gcgacacctt cagcctcgcc     1080

atgcacctgc agtacaagat ccatgaggcc cccttcgacc tgctgctgga gtggctgtat     1140

gtccctatcg accctacctg ccaacccatg aggctgtatt ccacctgtct ctaccatccc     1200

aacgctcctc agtgcctcag ccatatgaac tccggctgta ccttcacctc ccctcacctg     1260

gcccaacggg tggcctctac cgtgtatcag aattgcgagc acgccgacaa ctacacagcc     1320

tattgcctgg gcatcagcca tatggagcct tcctttggcc tgattctgca cgacggcgga     1380

accaccctga agtttgtgga tacccccgag tccctgagcg gcctgtacgt gttcgtcgtg     1440

tactttaacg gccacgtgga agccgtcgcc tacaccgtcg tgagcaccgt cgaccacttc     1500

gtgaacgcca tcgaagagcg gggctttcct cctacagccg gccagcctcc tgccacaacc     1560

aagcccaaag agatcacacc cgtgaaccct ggcaccagcc ccctcctcag gtatgctgcc     1620

tggacaggag gactggcttg atga                                            1644


<210>  3
<211>  516
<212>  PRT
<213>  ˹

<220>
<223>  ڵgE鵰

<400>  3

Ser Val Leu Arg Tyr Asp Asp Phe His Ile Asp Glu Asp Lys Leu Asp 
1               5                   10                  15      


Thr Asn Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser 
            20                  25                  30          


Ser Trp Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn 
        35                  40                  45              


Ser Pro Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn 
    50                  55                  60                  


Ala His Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser 
65                  70                  75                  80  


Gly Glu Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu 
                85                  90                  95      


Gly Asp Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp 
            100                 105                 110         


Arg His Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe 
        115                 120                 125             


Lys Gly Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Met Ile Glu Val 
    130                 135                 140                 


Ser Val Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg 
145                 150                 155                 160 


Ile Tyr Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu 
                165                 170                 175     


Thr Cys Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys 
            180                 185                 190         


His Thr Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu 
        195                 200                 205             


Asn Thr Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly 
    210                 215                 220                 


Lys Lys Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu 
225                 230                 235                 240 


Phe Asp Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu 
                245                 250                 255     


Lys Val Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn 
            260                 265                 270         


Met Arg Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr 
        275                 280                 285             


Trp Lys Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro 
    290                 295                 300                 


Gln Pro Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val 
305                 310                 315                 320 


Phe Ser Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys 
                325                 330                 335     


Ile His Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro 
            340                 345                 350         


Ile Asp Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr 
        355                 360                 365             


His Pro Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr 
    370                 375                 380                 


Phe Thr Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln 
385                 390                 395                 400 


Asn Cys Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser 
                405                 410                 415     


His Met Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr 
            420                 425                 430         


Leu Lys Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe 
        435                 440                 445             


Val Val Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val 
    450                 455                 460                 


Ser Thr Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro 
465                 470                 475                 480 


Pro Thr Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr 
                485                 490                 495     


Pro Val Asn Pro Gly Thr Ser Pro Leu Leu Arg Tyr Ala Ala Trp Thr 
            500                 505                 510         


Gly Gly Leu Ala 
        515     


