                         SEQUENCE LISTING

<110>  The University of Melbourne
       Olivia Newton-John Cancer Research Institute
       CSL Innovation Pty Ltd
 
<120>  Method of inhibiting or activating gamma delta T cells

<130>  530496PCT

<150>  AU2019902308
<151>  2019-06-28

<150>  AU2019904771
<151>  2019-12-17

<150>  AU2019904773
<151>  2019-12-17

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val 
1               5                   10                  15      

Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg 
            20                  25                  30          

Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala 
        35                  40                  45              

Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys 
    50                  55                  60                  

Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val 
65                  70                  75                  80  

Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu 
                85                  90                  95      

Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys 
            100                 105                 110         

Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu 
        115                 120                 125             

Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr 
    130                 135                 140                 

Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile 
145                 150                 155                 160 

Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro 
                165                 170                 175     

Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile 
            180                 185                 190         

Ile Val Val Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile 
        195                 200                 205             

Asn Lys Leu Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe 
    210                 215                 220                 

Glu Arg Glu Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg 
225                 230                 235                 240 

Val Gln Lys Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu 
                245                 250                 255     

Leu Arg Trp Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp 
            260                 265                 270         

Pro Asp Thr Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser 
        275                 280                 285             

Val Arg Arg Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn 
    290                 295                 300                 

Pro Glu Arg Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe 
305                 310                 315                 320 

Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu 
                325                 330                 335     

Trp Thr Val Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val 
            340                 345                 350         

Leu Leu Ile Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly 
        355                 360                 365             

Gln Tyr Arg Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu 
    370                 375                 380                 

Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val 
385                 390                 395                 400 

Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg 
                405                 410                 415     

Ser Ala Phe Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu 
            420                 425                 430         

Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val 
        435                 440                 445             

Thr Val Pro Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln 
    450                 455                 460                 

Ser Leu 
465     

<210>  2
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      

Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          

Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              

Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  

Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  

Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      

Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         

His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             

Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 

Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 

Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     

Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         

Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             

Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 

Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 

Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     

Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         

Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             

Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 

Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 

Arg Arg Thr Phe Leu His Ala Gly Pro Val 
                325                 330 

<210>  3
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      

Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          

Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              

Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  

Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  

Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      

Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         

His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             

Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 

Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 

Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     

Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         

Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             

Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 

Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 

Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     

Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         

Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             

Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 

Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 

Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     

Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         

Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             

Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 

Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 

Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     

Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         

Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             

Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 

Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 

Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     

Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         

Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         

<210>  4
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      

Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          

Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              

Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  

Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  

Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      

Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         

His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             

Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 

Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 

Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     

Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         

Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             

Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 

Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 

Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     

Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         

Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             

Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 

Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 

Arg Arg Thr Phe Leu His Ala Gly Pro Val 
                325                 330 

<210>  5
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      

Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          

Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              

Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  

Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  

Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      

Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         

Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             

Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 

Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 

Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     

Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         

Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             

Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 

Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 

Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     

Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         

Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             

Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 

Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 

<210>  6
<211>  346
<212>  PRT
<213>  Homo sapiens


<400>  6

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      

Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          

Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              

Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  

Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  

Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      

Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         

Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             

Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 

Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 

Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     

Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         

Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             

Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 

Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 

Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     

Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         

Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             

Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 

Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 

Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     

Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     

<210>  7
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lactadherin C1C2 sequence (aka MFG-E8)

<400>  7

Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln 
1               5                   10                  15      

Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp 
            20                  25                  30          

Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp 
        35                  40                  45              

Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu 
    50                  55                  60                  

Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu 
65                  70                  75                  80  

Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn 
                85                  90                  95      

Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu 
            100                 105                 110         

Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu 
        115                 120                 125             

Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His 
    130                 135                 140                 

Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 
145                 150                 155                 160 

Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln 
                165                 170                 175     

Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser 
            180                 185                 190         

Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala 
        195                 200                 205             

Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu 
    210                 215                 220                 

Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn 
225                 230                 235                 240 

Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn 
                245                 250                 255     

Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser 
            260                 265                 270         

Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu 
        275                 280                 285             

Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala 
    290                 295                 300                 

Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 
305                 310                 315             

<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Leu Ser Tyr Tyr Pro Ser Tyr Cys 
1               5                   

<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  9

tgggcaggag tcatgtcag                                                    19

<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10

gcaggatcaa actctgttat cttc                                              24

<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11

ggctctgtgt gtatatggtg c                                                 21

<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12

ctgacgatac atctgtgttc tttg                                              24

<210>  13
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13

ataccggtgc cattgagttg gtgcct                                            26

<210>  14
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14

tgttccggat atccttgggg tagaattcct tca                                    33

<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15

ataccggtgc aggtcaccta gagcaac                                           27

<210>  16
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16

cagcaattga aggaagaaaa atagtgggct tg                                     32

<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17

atgaagggcg cagccatcgg c                                                 21

<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18

gctacaccgc agtgtggc                                                     18

<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19

cttcatctac gcagagaagg acatctacgg                                        30

<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20

gtcatggtgt tgccctgg                                                     18

<210>  21
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21

ctgtgacaca gctggaatgg gcggcgag                                          28

<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22

gcgcagtagt agctgccc                                                     18

<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23

ggacatctgg cacagcccca g                                                 21

<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24

agcgccatac acacacag                                                     18

<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25

caagaccgcc gcactggaat gc                                                22

<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26

ctcagtgtct tggtgctg                                                     18

<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27

gccagactgg catgcgtggt g                                                 21

<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28

ggtcttgctc agtgtcttgg                                                   20

<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29

gtccggcatc gcaatcagcg c                                                 21

<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30

accacgcatt ccagtctgg                                                    19

<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31

gtccatcagc gccgatggca cc                                                22

<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32

accaggaact ggatcacttc                                                   20

<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33

ctacgatggc gccgtgcgga a                                                 21

<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34

ctgatggaca ccaggaactg g                                                 21

<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35

caccgtgcgg gcagagagcg gc                                                22

<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36

ccatcgtagc tgatggacac                                                   20

<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37

gcggaaagag gccggcatcc cttc                                              24

<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38

acggtgccat cgtagctg                                                     18

<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39

cggcatccct gctggcaagt t                                                 21

<210>  40
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40

ctctctttcc gcacggtg                                                     18

<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41

ggcaagttcg cggtggacag aatc                                              24

<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42

agaagggatg ccgctctc                                                     18

<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43

agaatccccg cgacaagcac c                                                 21

<210>  44
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44

gtccacctcg aacttgcc                                                     18

<210>  45
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45

actgaccatc gccaacgtgg aaaagcag                                          28

<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46

gtgctggtgc ttgtctcg                                                     18

<210>  47
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47

gaccatccac gccgtggaaa agcag                                             25

<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48

agtgtgctgg tgcttgtc                                                     18

<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49

cacaacgtgg caaagcagga tatc                                              24

<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50

gatggtcagt gtgctggt                                                     18

<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51

cgtggaaaag gcggatatcg cc                                                22

<210>  52
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52

ttgtggatgg tcagtgtg                                                     18

<210>  53
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53

agagctgggc gcgaaaatca aggtgttcg                                         29

<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54

tgttgggctt cccacagg                                                     18

<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR 2 top

<400>  55

tcacaaaggt ggttcttcct gtttt                                             25

<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR 2 bottom

<400>  56

aggaagaacc acctttgtga cggtg                                             25

<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR 4 top

<400>  57

caatagatgc atacggcaat                                                   20

<210>  58
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR 4 bottom

<400>  58

attgccgtat gcatctattg cggtg                                             25

<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sc-404202 A

<400>  59

ggcacttacg agatgcatac                                                   20

<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sc-404202 B

<400>  60

gagagacatt cagcctataa                                                   20

<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sc-404202 C

<400>  61

accatcagaa gttccctcct                                                   20

<210>  62
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR1 MiSeqF

<400>  62

gtgacctatg aactcaggag tccttgagtg acgggagagg tt                          42

<210>  63
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR1 MiSeqR

<400>  63

ctgagacttg cacatcgcag ctccttttgg acagtgctgg t                           41

<210>  64
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR2 MiSeqF

<400>  64

gtgacctatg aactcaggag tccctttgtt gaacagccca gt                          42

<210>  65
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR2 MiSeqR

<400>  65

ctgagacttg cacatcgcag ctaggacctg ccttcttgga a                           41

<210>  66
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR3 MiSeqF

<400>  66

gtgacctatg aactcaggag tcccgagaaa aatgctgagg ac                          42

<210>  67
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR3 MiSeqR

<400>  67

ctgagacttg cacatcgcag caatgggcct gaggttagga g                           41

<210>  68
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR4 MiSeqF

<400>  68

gtgacctatg aactcaggag tcagaaagca ggagagcagg tg                          42

<210>  69
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A1 CRISPR4 MiSeqR

<400>  69

ctgagacttg cacatcgcag cttgcacacg ttctttctcc a                           41

<210>  70
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soluble delta chain 2

<220>
<221>  X
<222>  (20)..(20)
<223>  V or I

<220>
<221>  X
<222>  (49)..(49)
<223>  M or I

<400>  70

Glu Thr Gly Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
1               5                   10                  15      

Ser Ile Gly Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
            20                  25                  30          

Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
        35                  40                  45              

Xaa Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
    50                  55                  60                  

Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
65                  70                  75                  80  

Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
                85                  90                  95      

Cys Asp Pro Leu Leu Gly Ser Glu Arg Leu Gly Asp Thr Gly Ile Asp 
            100                 105                 110         

Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser 
        115                 120                 125             

Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn 
    130                 135                 140                 

Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn 
145                 150                 155                 160 

Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile 
                165                 170                 175     

Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp 
            180                 185                 190         

Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His 
        195                 200                 205             

Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
    210                 215                 220                 

Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Ala Ser Gly Leu 
225                 230                 235                 240 

Val Pro Arg Gly Ser Gly Ser Gly Leu Thr Asp Thr Leu Gln Ala Glu 
                245                 250                 255     

Thr Asp Gln Leu Glu Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala 
            260                 265                 270         

Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala Tyr 
        275                 280                 285             

Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
    290                 295                 300                 

Glu His His His His His His 
305                 310     

<210>  71
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soluble delta chain 2 (clone 3)

<220>
<221>  X
<222>  (20)..(20)
<223>  V or I

<220>
<221>  X
<222>  (49)..(49)
<223>  M or I

<400>  71

Glu Thr Gly Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
1               5                   10                  15      

Ser Ile Gly Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
            20                  25                  30          

Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
        35                  40                  45              

Xaa Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
    50                  55                  60                  

Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
65                  70                  75                  80  

Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
                85                  90                  95      

Cys Asp Pro Val Gln Val Thr Gly Gly Tyr Lys Val Asp Lys Leu Ile 
            100                 105                 110         

Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His 
        115                 120                 125             

Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys 
    130                 135                 140                 

Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser 
145                 150                 155                 160 

Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser 
                165                 170                 175     

Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser 
            180                 185                 190         

Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp 
        195                 200                 205             

Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
    210                 215                 220                 

Glu Asn Thr Lys Gln Pro Ser Lys Ser Ala Ser Gly Leu Val Pro Arg 
225                 230                 235                 240 

Gly Ser Gly Ser Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln 
                245                 250                 255     

Leu Glu Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu 
            260                 265                 270         

Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala Tyr Gly Ser Gly 
        275                 280                 285             

Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu His His 
    290                 295                 300                 

His His His His 
305             

<210>  72
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soluble delta chain 2 (clone 4)

<220>
<221>  X
<222>  (20)..(20)
<223>  V or I

<220>
<221>  X
<222>  (49)..(49)
<223>  M or I

<400>  72

Glu Thr Gly Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
1               5                   10                  15      

Ser Ile Gly Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
            20                  25                  30          

Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
        35                  40                  45              

Xaa Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
    50                  55                  60                  

Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
65                  70                  75                  80  

Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
                85                  90                  95      

Cys Asp Thr Val Gln Arg Leu Gly Asp Arg Pro Thr Asp Lys Leu Ile 
            100                 105                 110         

Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His 
        115                 120                 125             

Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys 
    130                 135                 140                 

Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser 
145                 150                 155                 160 

Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser 
                165                 170                 175     

Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser 
            180                 185                 190         

Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp 
        195                 200                 205             

Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr 
    210                 215                 220                 

Glu Asn Thr Lys Gln Pro Ser Lys Ser Ala Ser Gly Leu Val Pro Arg 
225                 230                 235                 240 

Gly Ser Gly Ser Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln 
                245                 250                 255     

Leu Glu Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu 
            260                 265                 270         

Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala Tyr Gly Ser Gly 
        275                 280                 285             

Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu His His 
    290                 295                 300                 

His His His His 
305             

<210>  73
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soluble delta chain 2 (clone 5)

<220>
<221>  X
<222>  (20)..(20)
<223>  V or I

<220>
<221>  X
<222>  (49)..(49)
<223>  M or I

<400>  73

Glu Thr Gly Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
1               5                   10                  15      

Ser Ile Gly Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
            20                  25                  30          

Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
        35                  40                  45              

Xaa Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
    50                  55                  60                  

Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
65                  70                  75                  80  

Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
                85                  90                  95      

Cys Asp Gly Ile Leu Gly Asp Ser His Thr Asp Lys Leu Ile Phe Gly 
            100                 105                 110         

Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys 
        115                 120                 125             

Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val 
    130                 135                 140                 

Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys 
145                 150                 155                 160 

Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys 
                165                 170                 175     

Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr 
            180                 185                 190         

Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu 
        195                 200                 205             

Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn 
    210                 215                 220                 

Thr Lys Gln Pro Ser Lys Ser Ala Ser Gly Leu Val Pro Arg Gly Ser 
225                 230                 235                 240 

Gly Ser Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu 
                245                 250                 255     

Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu 
            260                 265                 270         

Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala Tyr Gly Ser Gly Leu Asn 
        275                 280                 285             

Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu His His His His 
    290                 295                 300                 

His His 
305     

<210>  74
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soluble delta chain 2 (clone 7)

<220>
<221>  X
<222>  (20)..(20)
<223>  V or I

<220>
<221>  X
<222>  (49)..(49)
<223>  M or I

<400>  74

Glu Thr Gly Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
1               5                   10                  15      

Ser Ile Gly Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
            20                  25                  30          

Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
        35                  40                  45              

Xaa Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
    50                  55                  60                  

Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
65                  70                  75                  80  

Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
                85                  90                  95      

Cys Asp Arg Val Leu Gly Asp Thr Arg Trp Thr Asp Lys Leu Ile Phe 
            100                 105                 110         

Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr 
        115                 120                 125             

Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu 
    130                 135                 140                 

Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser 
145                 150                 155                 160 

Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly 
                165                 170                 175     

Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val 
            180                 185                 190         

Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe 
        195                 200                 205             

Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu 
    210                 215                 220                 

Asn Thr Lys Gln Pro Ser Lys Ser Ala Ser Gly Leu Val Pro Arg Gly 
225                 230                 235                 240 

Ser Gly Ser Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu 
                245                 250                 255     

Glu Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys 
            260                 265                 270         

Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala Tyr Gly Ser Gly Leu 
        275                 280                 285             

Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu His His His 
    290                 295                 300                 

His His His 
305         

<210>  75
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  soluble delta chain 2 variable region

<220>
<221>  X
<222>  (17)..(17)
<223>  V or I

<220>
<221>  X
<222>  (46)..(46)
<223>  V or I

<400>  75

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      

Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          

Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Xaa Thr Phe 
        35                  40                  45              

Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  

Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  

Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Pro 
                85                  90                  95      

Leu Leu Gly Ser Glu Arg Leu Gly Asp Thr Gly Ile Asp Lys Leu Ile 
            100                 105                 110         

Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro 
        115                 120             

<210>  76
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of gamma 2 (clone 3)

<220>
<221>  X
<222>  (17)..(17)
<223>  V or I

<220>
<221>  X
<222>  (46)..(46)
<223>  M or I

<400>  76

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      

Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          

Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Xaa Thr Phe 
        35                  40                  45              

Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  

Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  

Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Pro 
                85                  90                  95      

Val Gln Val Thr Gly Gly Tyr Lys Val Asp Lys Leu Ile Phe Gly Lys 
            100                 105                 110         

Gly Thr Arg Val Thr Val Glu Pro 
        115                 120 

<210>  77
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of Soluble delta chain 2 (clone 4)

<220>
<221>  X
<222>  (17)..(17)
<223>  V ot I

<220>
<221>  X
<222>  (46)..(46)
<223>  M ot I

<400>  77

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      

Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          

Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Xaa Thr Phe 
        35                  40                  45              

Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  

Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  

Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Thr 
                85                  90                  95      

Val Gln Arg Leu Gly Asp Arg Pro Thr Asp Lys Leu Ile Phe Gly Lys 
            100                 105                 110         

Gly Thr Arg Val Thr Val Glu Pro 
        115                 120 

<210>  78
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of Soluble delta chain 2 (clone 5)

<220>
<221>  X
<222>  (17)..(17)
<223>  V or I

<220>
<221>  X
<222>  (46)..(46)
<223>  M or I

<400>  78

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      

Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          

Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Xaa Thr Phe 
        35                  40                  45              

Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  

Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  

Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Gly 
                85                  90                  95      

Ile Leu Gly Asp Ser His Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr 
            100                 105                 110         

Arg Val Thr Val Glu Pro 
        115             

<210>  79
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of Soluble delta chain 2 (clone 7)

<220>
<221>  X
<222>  (17)..(17)
<223>  V or I

<220>
<221>  X
<222>  (46)..(46)
<223>  M or I

<400>  79

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      

Xaa Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          

Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Xaa Thr Phe 
        35                  40                  45              

Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  

Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  

Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Arg 
                85                  90                  95      

Val Leu Gly Asp Thr Arg Trp Thr Asp Lys Leu Ile Phe Gly Lys Gly 
            100                 105                 110         

Thr Arg Val Thr Val Glu Pro 
        115                 

<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 gamma (clone 3)

<400>  80

Cys Ala Cys Asp Pro Val Gln Val Thr Gly Gly Tyr Lys Val Asp Lys 
1               5                   10                  15      

Leu Ile Phe 
            

<210>  81
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  of CDR3 gamma (clone 4)

<400>  81

Cys Ala Cys Asp Thr Val Gln Arg Leu Gly Asp Arg Pro Thr Asp Lys 
1               5                   10                  15      

Leu Ile Phe 
            

<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  of CDR3 gamma (clone 5)

<400>  82

Cys Ala Cys Asp Gly Ile Leu Gly Asp Ser His Thr Asp Lys Leu Ile 
1               5                   10                  15      

Phe 
    

<210>  83
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  of CDR3 gamma (clone 6)

<400>  83

Cys Ala Cys Asp Pro Leu Leu Gly Ser Glu Arg Leu Gly Asp Thr Gly 
1               5                   10                  15      

Ile Asp Lys Leu Ile Phe 
            20          

<210>  84
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  of CDR3 gamma (clone 7)

<400>  84

Cys Ala Cys Asp Arg Val Leu Gly Asp Thr Arg Trp Thr Asp Lys Leu 
1               5                   10                  15      

Ile Phe 
        

<210>  85
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soluble gamma chain 9

<400>  85

Glu Thr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys 
1               5                   10                  15      

Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr 
            20                  25                  30          

Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val 
        35                  40                  45              

Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu 
    50                  55                  60                  

Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr 
65                  70                  75                  80  

Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala 
                85                  90                  95      

Thr Tyr Tyr Cys Ala Leu Trp Glu Ser Gln Glu Leu Gly Lys Lys Ile 
            100                 105                 110         

Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu 
        115                 120                 125             

Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala 
    130                 135                 140                 

Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys 
145                 150                 155                 160 

Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn 
                165                 170                 175     

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr 
            180                 185                 190         

Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys 
        195                 200                 205             

Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp 
    210                 215                 220                 

Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
225                 230                 235                 240 

Pro Lys Asp Asn Ala Ser Gly Leu Val Pro Arg Gly Ser Gly Ser Gly 
                245                 250                 255     

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
            260                 265                 270         

Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
        275                 280                 285             

Leu Lys Gln Lys Val Met Asn Tyr 
    290                 295     

<210>  86
<211>  296
<212>  PRT
<213>  artificial

<220>
<223>  Soluble gamma chain 9 (clone 3)

<400>  86

Glu Thr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys 
1               5                   10                  15      

Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr 
            20                  25                  30          

Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val 
        35                  40                  45              

Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu 
    50                  55                  60                  

Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr 
65                  70                  75                  80  

Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala 
                85                  90                  95      

Thr Tyr Tyr Cys Ala Leu Trp Glu Val His Glu Leu Gly Lys Lys Ile 
            100                 105                 110         

Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu 
        115                 120                 125             

Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala 
    130                 135                 140                 

Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys 
145                 150                 155                 160 

Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn 
                165                 170                 175     

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr 
            180                 185                 190         

Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys 
        195                 200                 205             

Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp 
    210                 215                 220                 

Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
225                 230                 235                 240 

Pro Lys Asp Asn Ala Ser Gly Leu Val Pro Arg Gly Ser Gly Ser Gly 
                245                 250                 255     

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
            260                 265                 270         

Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
        275                 280                 285             

Leu Lys Gln Lys Val Met Asn Tyr 
    290                 295     

<210>  87
<211>  296
<212>  PRT
<213>  artificial

<220>
<223>  gamma 9 (clone 4)

<400>  87

Glu Thr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys 
1               5                   10                  15      

Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr 
            20                  25                  30          

Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val 
        35                  40                  45              

Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu 
    50                  55                  60                  

Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr 
65                  70                  75                  80  

Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala 
                85                  90                  95      

Thr Tyr Tyr Cys Ala Leu Trp Glu Val Gln Glu Leu Gly Lys Lys Ile 
            100                 105                 110         

Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu 
        115                 120                 125             

Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala 
    130                 135                 140                 

Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys 
145                 150                 155                 160 

Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn 
                165                 170                 175     

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr 
            180                 185                 190         

Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys 
        195                 200                 205             

Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp 
    210                 215                 220                 

Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
225                 230                 235                 240 

Pro Lys Asp Asn Ala Ser Gly Leu Val Pro Arg Gly Ser Gly Ser Gly 
                245                 250                 255     

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
            260                 265                 270         

Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
        275                 280                 285             

Leu Lys Gln Lys Val Met Asn Tyr 
    290                 295     

<210>  88
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma 9 (clone 5)

<400>  88

Glu Thr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys 
1               5                   10                  15      

Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr 
            20                  25                  30          

Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val 
        35                  40                  45              

Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu 
    50                  55                  60                  

Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr 
65                  70                  75                  80  

Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala 
                85                  90                  95      

Thr Tyr Tyr Cys Ala Leu Trp Glu Leu Ala Glu Leu Gly Lys Lys Ile 
            100                 105                 110         

Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu 
        115                 120                 125             

Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala 
    130                 135                 140                 

Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys 
145                 150                 155                 160 

Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn 
                165                 170                 175     

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr 
            180                 185                 190         

Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys 
        195                 200                 205             

Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp 
    210                 215                 220                 

Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
225                 230                 235                 240 

Pro Lys Asp Asn Ala Ser Gly Leu Val Pro Arg Gly Ser Gly Ser Gly 
                245                 250                 255     

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
            260                 265                 270         

Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
        275                 280                 285             

Leu Lys Gln Lys Val Met Asn Tyr 
    290                 295     

<210>  89
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma 9 (clone 7)

<400>  89

Glu Thr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys 
1               5                   10                  15      

Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr 
            20                  25                  30          

Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val 
        35                  40                  45              

Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu 
    50                  55                  60                  

Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr 
65                  70                  75                  80  

Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala 
                85                  90                  95      

Thr Tyr Tyr Cys Ala Leu Trp Glu Val His Glu Leu Gly Lys Lys Ile 
            100                 105                 110         

Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu 
        115                 120                 125             

Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala 
    130                 135                 140                 

Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys 
145                 150                 155                 160 

Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn 
                165                 170                 175     

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr 
            180                 185                 190         

Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys 
        195                 200                 205             

Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp 
    210                 215                 220                 

Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
225                 230                 235                 240 

Pro Lys Asp Asn Ala Ser Gly Leu Val Pro Arg Gly Ser Gly Ser Gly 
                245                 250                 255     

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
            260                 265                 270         

Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
        275                 280                 285             

Leu Lys Gln Lys Val Met Asn Tyr 
    290                 295     

<210>  90
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  soluble gamma chain 9 variable region

<400>  90

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      

Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          

Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              

Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  

Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  

Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Leu Trp Glu Ser Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
            100                 105                 110         

Gly Pro Gly Thr Lys Leu Ile Ile Thr 
        115                 120     

<210>  91
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of gamma 9 (clone 3)

<400>  91

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      

Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          

Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              

Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  

Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  

Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Leu Trp Glu Val His Glu Leu Gly Lys Lys Ile Lys Val Phe 
            100                 105                 110         

Gly Pro Gly Thr Lys Leu Ile Ile Thr 
        115                 120     

<210>  92
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of gamma 9 (clone 4)

<400>  92

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      

Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          

Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              

Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  

Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  

Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Leu Trp Glu Val Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
            100                 105                 110         

Gly Pro Gly Thr Lys Leu Ile Ile Thr 
        115                 120     

<210>  93
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of gamma 9 (clone 5)

<400>  93

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      

Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          

Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              

Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  

Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  

Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Leu Trp Glu Leu Ala Glu Leu Gly Lys Lys Ile Lys Val Phe 
            100                 105                 110         

Gly Pro Gly Thr Lys Leu Ile Ile Thr 
        115                 120     

<210>  94
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of gamma 9 (clone 7)

<400>  94

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      

Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          

Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              

Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  

Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  

Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Leu Trp Glu Val His Glu Leu Gly Lys Lys Ile Lys Val Phe 
            100                 105                 110         

Gly Pro Gly Thr Lys Leu Ile Ile Thr 
        115                 120     

<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 gamma (clone 3)

<400>  95

Cys Ala Leu Trp Glu Val His Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      

<210>  96
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 gamma (clone 4)

<400>  96

Cys Ala Leu Trp Glu Val Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      

<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 gamma (clone 5)

<400>  97

Cys Ala Leu Trp Glu Leu Ala Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      

<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 gamma (clone 6)

<400>  98

Cys Ala Leu Trp Glu Ser Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      

<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 gamma (clone 7)

<400>  99

Cys Ala Leu Trp Glu Val His Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      

<210>  100
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VH

<400>  100

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          

Pro Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ser Ile Ser Ser Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Ala Leu Val Ser Asp Thr Asp Phe Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>  101
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VL

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      

Glu Ser Thr Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Asn 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  

Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VH CDR1

<400>  102

Gly Phe Thr Phe Ser His Tyr Pro 
1               5               

<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VH CDR2

<400>  103

Ile Ser Ser Ser Gly Gly Ser Thr 
1               5               

<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VH CDR3

<400>  104

Ala Ala Leu Val Ser Asp Thr Asp Phe 
1               5                   

<210>  105
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VL CDR1

<400>  105

Gln Ser Val Thr Ser Asn 
1               5       

<210>  106
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VL CDR2

<400>  106

Gly Ala Ser 
1           

<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Hu34C VL CDR3

<400>  107

Gln Gln Tyr Asn Asn Trp Pro Arg Thr 
1               5                   

<210>  108
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VH

<400>  108

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          

Ser Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Arg Ile Ser Pro Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Thr Thr Pro Thr Val Thr Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>  109
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VL

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Leu 
                85                  90                  95      

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105             

<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VH CDR1

<400>  110

Gly Phe Thr Phe Ser Ile Tyr Ser 
1               5               

<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VH CDR2

<400>  111

Ile Ser Pro Ser Gly Gly Gly Thr 
1               5               

<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VH CDR3

<400>  112

Thr Thr Pro Thr Val Thr Thr Asp Tyr 
1               5                   

<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VL CDR1

<400>  113

Gln Ser Val Ser Ser Ser Tyr 
1               5           

<210>  114
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VL CDR2

<400>  114

Gly Ala Ser 
1           

<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 227 VL CDR3

<400>  115

Gln Gln Tyr Asp Ser Ser Leu Trp Thr 
1               5                   

<210>  116
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VH

<400>  116

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Ser Ser Gly Gly Phe Thr Pro Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Thr Gly Gly Ser Gly Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         

Val Ser Ser 
        115 

<210>  117
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VL

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Ser Trp 
            20                  25                  30          

Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Arg Ala Ser Thr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Glu Ser Gly Thr Thr Phe Thr Leu Thr Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  

Asp Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Thr Phe Pro Trp 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105         

<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VH CDR1

<400>  118

Gly Phe Thr Phe Ser His Tyr Ser 
1               5               

<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VH CDR2

<400>  119

Ile Ser Ser Ser Gly Gly Phe Thr 
1               5               

<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VH CDR3

<400>  120

Thr Gly Gly Ser Gly Phe Asp Ile 
1               5               

<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VL CDR1

<400>  121

Gln Thr Ile Ser Ser Trp 
1               5       

<210>  122
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VL CDR2

<400>  122

Arg Ala Ser 
1           

<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 236 VL CDR3

<400>  123

Gln Gln Tyr Ala Thr Phe Pro Trp Thr 
1               5                   

<210>  124
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VH

<400>  124

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Met Tyr 
            20                  25                  30          

Thr Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Gly Ser Ser Gly Gly His Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Tyr Gly His Thr Phe Glu Thr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>  125
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VL

<400>  125

Gln Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      

Ser Gly Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     

<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VH CDR1

<400>  126

Gly Phe Thr Phe Ser Met Tyr Thr 
1               5               

<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VH CDR2

<400>  127

Ile Gly Ser Ser Gly Gly His Thr 
1               5               

<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VH CDR3

<400>  128

Ala Arg Tyr Gly His Thr Phe Glu Thr 
1               5                   

<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VL CDR1

<400>  129

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               

<210>  130
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VL CDR2

<400>  130

Arg Asn Asn 
1           

<210>  131
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 266 VL CDR3

<400>  131

Ala Ala Trp Asp Asp Ser Leu Ser Gly Ser Tyr Val 
1               5                   10          

<210>  132
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VH

<400>  132

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          

Val Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ser Ile Ser Pro Ser Gly Gly Leu Thr Val Tyr Val Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Val Gly Tyr Ser Ser Ser Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>  133
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VL

<400>  133

Gln Tyr Glu Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      

Thr Val Thr Ile Ser Cys Thr Arg Asn Gly Gly Ser Ile Ala Ser Asn 
            20                  25                  30          

Ala Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Ile Thr Val 
        35                  40                  45              

Ile Tyr Asp Asp Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Ile Asp Ser Ser Ser Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  

Leu Thr Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Phe Asp Thr 
                85                  90                  95      

Thr Ser Gln Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VH CDR1

<400>  134

Gly Phe Thr Phe Ser Thr Tyr Val 
1               5               

<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VH CDR2

<400>  135

Ile Ser Pro Ser Gly Gly Leu Thr 
1               5               

<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VH CDR3

<400>  136

Ala Arg Val Gly Tyr Ser Ser Ser Asp Ile 
1               5                   10  

<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VL CDR1

<400>  137

Gly Gly Ser Ile Ala Ser Asn Ala 
1               5               

<210>  138
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VL CDR2

<400>  138

Asp Asp Ser 
1           

<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of clone 267 VL CDR3

<400>  139

Leu Ser Phe Asp Thr Thr Ser Gln Ile 
1               5                   

<210>  140
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the VL of antibody 244

<400>  140

Gln Ser Val Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      

Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Arg Ile Gly Ser Asn 
            20                  25                  30          

Tyr Val His Trp Tyr Gln His Leu Pro Gly Arg Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  

Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Tyr Asp Asn Asn Val 
                85                  90                  95      

Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             

<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of the VL of antibody 244

<400>  141

Ser Gly Arg Ile Gly Ser Asn Tyr 
1               5               

<210>  142
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of the VL of antibody 244

<400>  142

Gly Asn Ser 
1           

<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of the VL of antibody 244

<400>  143

Gln Thr Tyr Asp Asn Asn Val Trp Val 
1               5                   

<210>  144
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the VH of antibody 244

<400>  144

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Arg Ile Gly Pro Ser Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Leu Gly Arg Gly Ala Val Ala Glu Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of the VH of antibody 244

<400>  145

Gly Phe Thr Phe Ser Glu Tyr Ser 
1               5               

<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of the VH of antibody 244

<400>  146

Ile Gly Pro Ser Gly Gly Gly Thr 
1               5               

<210>  147
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of the VH of antibody 244

<400>  147

Ala Arg Leu Gly Arg Gly Ala Val Ala Glu Leu Asp Tyr 
1               5                   10              

<210>  148
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the VL of antibody 253

<400>  148

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Leu Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Arg Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Asp Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Val Phe Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Val 
                85                  90                  95      

His Gly Pro Val Phe Gly Gly Gly Thr Met Val Thr Val Leu 
            100                 105                 110 

<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of the VL of antibody 253

<400>  149

Ser Ser Asn Ile Gly Ser Asn Arg 
1               5               

<210>  150
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of the VL of antibody 253

<400>  150

Ser Asn Asn 
1           

<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of the VL of antibody 253

<400>  151

Ala Ala Trp Asp Asp Ser Val His Gly Pro Val 
1               5                   10      

<210>  152
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the VH of antibody 253

<400>  152

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          

Asp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Ser Pro Ser Gly Gly Leu Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp His Tyr Asp Ser Ser Gly Arg Ala Thr Asn Tyr Tyr Tyr 
            100                 105                 110         

Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         

<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of the VH of antibody 253

<400>  153

Gly Phe Thr Phe Ser Thr Tyr Asp 
1               5               

<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of the VH of antibody 253

<400>  154

Ile Ser Pro Ser Gly Gly Leu Thr 
1               5               

<210>  155
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of the VH of antibody 253

<400>  155

Ala Arg Asp His Tyr Asp Ser Ser Gly Arg Ala Thr Asn Tyr Tyr Tyr 
1               5                   10                  15      

Tyr Met Asp Val 
            20  

<210>  156
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the VL of antibody 259

<400>  156

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Glu Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Thr Val Ser Trp Phe Gln Gln Leu Pro Gly Ser Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Asn Asp His Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Gln 
65                  70                  75                  80  

Ser Gln Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      

Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210>  157
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of the VL of antibody 259

<400>  157

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               

<210>  158
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of the VL of antibody 259

<400>  158

Asn Asp His 
1           

<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of the VL of antibody 259

<400>  159

Ser Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      

<210>  160
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the VH of antibody 259

<400>  160

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Arg Ile Gly Pro Ser Gly Gly Gly Thr Met Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Leu Gly Gly Leu Ser Val Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of the VH of antibody 259

<400>  161

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of the VH of antibody 259

<400>  162

Ile Gly Pro Ser Gly Gly Gly Thr 
1               5               

<210>  163
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of the VH of antibody 259

<400>  163

Ala Arg Asp Leu Gly Gly Leu Ser Val Leu Phe Asp Tyr 
1               5                   10              