                         SEQUENCE LISTING

<110>  Kite Pharma, Inc.
 
<120>  TGF-Beta Receptors and Methods of Use

<130>  K1075.P/82352-321521

<140>  K1075.P
<141>  2020-06-17

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  1509
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaggcgg cggtcgctgc tccgcgtccc cggctgctcc tcctcgtgct ggcggcggcg       60

gcggcggcgg cggcggcgct gctcccgggg gcgacggcgt tacagtgttt ctgccacctc      120

tgtacaaaag acaattttac ttgtgtgaca gatgggctct gctttgtctc tgtcacagag      180

accacagaca aagttataca caacagcatg tgtatagctg aaattgactt aattcctcga      240

gataggccgt ttgtatgtgc accctcttca aaaactgggt ctgtgactac aacatattgc      300

tgcaatcagg accattgcaa taaaatagaa cttccaacta ctgtaaagtc atcacctggc      360

cttggtcctg tggaactggc agctgtcatt gctggaccag tgtgcttcgt ctgcatctca      420

ctcatgttga tggtctatat ctgccacaac cgcactgtca ttcaccatcg agtgccaaat      480

gaagaggacc cttcattaga tcgccctttt atttcagagg gtactacgtt gaaagactta      540

atttatgata tgacaacgtc aggttctggc tcaggtttac cattgcttgt tcagagaaca      600

attgcgagaa ctattgtgtt acaagaaagc attggcaaag gtcgatttgg agaagtttgg      660

agaggaaagt ggcggggaga agaagttgct gttaagatat tctcctctag agaagaacgt      720

tcgtggttcc gtgaggcaga gatttatcaa actgtaatgt tacgtcatga aaacatcctg      780

ggatttatag cagcagacaa taaagacaat ggtacttgga ctcagctctg gttggtgtca      840

gattatcatg agcatggatc cctttttgat tacttaaaca gatacacagt tactgtggaa      900

ggaatgataa aacttgctct gtccacggcg agcggtcttg cccatcttca catggagatt      960

gttggtaccc aaggaaagcc agccattgct catagagatt tgaaatcaaa gaatatcttg     1020

gtaaagaaga atggaacttg ctgtattgca gacttaggac tggcagtaag acatgattca     1080

gccacagata ccattgatat tgctccaaac cacagagtgg gaacaaaaag gtacatggcc     1140

cctgaagttc tcgatgattc cataaatatg aaacattttg aatccttcaa acgtgctgac     1200

atctatgcaa tgggcttagt attctgggaa attgctcgac gatgttccat tggtggaatt     1260

catgaagatt accaactgcc ttattatgat cttgtacctt ctgacccatc agttgaagaa     1320

atgagaaaag ttgtttgtga acagaagtta aggccaaata tcccaaacag atggcagagc     1380

tgtgaagcct tgagagtaat ggctaaaatt atgagagaat gttggtatgc caatggagca     1440

gctaggctta cagcattgcg gattaagaaa acattatcgc aactcagtca acaggaaggc     1500

atcaaaatg                                                             1509


<210>  2
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210>  3
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain

<400>  3

Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
                85                  90              


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane Domain

<400>  4

Ala Ala Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met 
1               5                   10                  15      


Leu Met Val Tyr Ile 
            20      


<210>  5
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + Transmembrane Domain

<400>  5

Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala Val 
                85                  90                  95      


Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met Val 
            100                 105                 110         


Tyr Ile 
        


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular Domain

<400>  6

Arg Val Asn Arg Gln 
1               5   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + Transmembrane Domain + Intracellular 
       Domain

<400>  7

Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala Val 
                85                  90                  95      


Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met Val 
            100                 105                 110         


Tyr Ile Arg Val Asn Arg Gln 
        115                 


<210>  8
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal

<400>  8

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala 
    


<210>  9
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal + Extracellular Domain

<400>  9

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
        115                 120                 125     


<210>  10
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal + Extracellular Domain + Transmembrane Domain + 
       Intracellular Domain

<400>  10

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Arg Val Asn Arg Gln 
145                 150         


<210>  11
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + Transmembrane Domain

<400>  11
ttacagtgct tctgccattt atgcaccaag gacaacttca cttgtgtcac cgatggttta       60

tgcttcgtga gcgtgaccga gaccaccgac aaggtgatcc acaacagcat gtgcatcgcc      120

gagatcgatt taatccctcg tgacagaccc ttcgtgtgcg cccctagcag caagaccggc      180

agcgtgacca ccacctactg ctgcaaccaa gatcactgca acaagatcga gctgcccacc      240

accgtgaaga gcagccccgg tttaggaccc gttgaactgg ctgccgtgat tgccggcccc      300

gtgtgctttg tgtgcatctc tttaatgctg atggtgtaca tt                         342


<210>  12
<211>  1701
<212>  DNA
<213>  Homo sapiens

<400>  12
atgggcaggg gcctgctgag gggcctgtgg cccctgcaca tcgtgctgtg gaccaggatc       60

gccagcacca tcccccccca cgtgcagaag agcgtgaaca acgacatgat cgtgaccgac      120

aacaacggcg ccgtgaagtt cccccagctg tgcaagttct gcgacgtgag gttcagcacc      180

tgcgacaacc agaagagctg catgagcaac tgcagcatca ccagcatctg cgagaagccc      240

caggaggtgt gcgtggccgt gtggaggaag aacgacgaga acatcaccct ggagaccgtg      300

tgccacgacc ccaagctgcc ctaccacgac ttcatcctgg aggacgccgc cagccccaag      360

tgcatcatga aggagaagaa gaagcccggc gagaccttct tcatgtgcag ctgcagcagc      420

gacgagtgca acgacaacat catcttcagc gaggagtaca acaccagcaa ccccgacctg      480

ctgctggtga tcttccaggt gaccggcatc agcctgctgc cccccctggg cgtggccatc      540

agcgtgatca tcatcttcta ctgctacagg gtgaacaggc agcagaagct gagcagcacc      600

tgggagaccg gcaagaccag gaagctgatg gagttcagcg agcactgcgc catcatcctg      660

gaggacgaca ggagcgacat cagcagcacc tgcgccaaca acatcaacca caacaccgag      720

ctgctgccca tcgagctgga caccctggtg ggcaagggca ggttcgccga ggtgtacaag      780

gccaagctga agcagaacac cagcgagcag ttcgagaccg tggccgtgaa gatcttcccc      840

tacgaggagt acgccagctg gaagaccgag aaggacatct tcagcgacat caacctgaag      900

cacgagaaca tcctgcagtt cctgaccgcc gaggagagga agaccgagct gggcaagcag      960

tactggctga tcaccgcctt ccacgccaag ggcaacctgc aggagtacct gaccaggcac     1020

gtgatcagct gggaggacct gaggaagctg ggcagcagcc tggccagggg catcgcccac     1080

ctgcacagcg accacacccc ctgcggcagg cccaagatgc ccatcgtgca cagggacctg     1140

aagagcagca acatcctggt gaagaacgac ctgacctgct gcctgtgcga cttcggcctg     1200

agcctgaggc tggaccccac cctgagcgtg gacgacctgg ccaacagcgg ccaggtgggc     1260

accgccaggt acatggcccc cgaggtgctg gagagcagga tgaacctgga gaacgtggag     1320

agcttcaagc agaccgacgt gtacagcatg gccctggtgc tgtgggagat gaccagcagg     1380

tgcaacgccg tgggcgaggt gaaggactac gagcccccct tcggcagcaa ggtgagggag     1440

cacccctgcg tggagagcat gaaggacaac gtgctgaggg acaggggcag gcccgagatc     1500

cccagcttct ggctgaacca ccagggcatc cagatggtgt gcgagaccct gaccgagtgc     1560

tgggaccacg accccgaggc caggctgacc gcccagtgcg tggccgagag gttcagcgag     1620

ctggagcacc tggacaggct gagcggcagg agctgcagcg aggagaagat ccccgaggac     1680

ggcagcctga acaccaccaa g                                               1701


<210>  13
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  14
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated TGF beta R2

<400>  14

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln 
        


<210>  15
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain

<400>  15

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135         


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane Domain

<400>  16

Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro 
1               5                   10                  15      


Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr 
            20                  25                  30  


<210>  17
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + Transmembrane Domain

<400>  17

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
145                 150                 155                 160 


Ile Ile Ile Phe Tyr Cys Tyr 
                165         


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7Ralpha Transmembrane Domain

<400>  18

Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu 
1               5                   10                  15      


Leu Val Ile Leu 
            20  


<210>  19
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + IL7Ralpha Transmembrane Domain

<400>  19

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser Gly Pro Ile Leu Leu Thr 
    130                 135                 140                 


Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu 
145                 150                 155                 


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7Ralpha "CPT" Transmembrane Domain

<400>  20

Pro Ile Leu Leu Thr Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser 
1               5                   10                  15      


Val Ala Leu Leu Val Ile Leu 
            20              


<210>  21
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + IL7Ralpha "CPT"

<400>  21

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser Gly Pro Ile Leu Leu Thr 
    130                 135                 140                 


Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val 
145                 150                 155                 160 


Ile Leu 
        


<210>  22
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7Ralpha Intracellular Domain

<400>  22

Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser 
1               5                   10                  15      


Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg 
            20                  25                  30          


Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln 
        35                  40                  45              


Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe 
    50                  55                  60                  


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
65                  70                  75                  80  


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
                85                  90                  95      


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
            100                 105                 110         


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
        115                 120                 125             


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
    130                 135                 140                 


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
145                 150                 155                 160 


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
                165                 170                 175     


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
            180                 185                 190         


Met Ser Ser Phe Tyr Gln Asn Gln 
        195                 200 


<210>  23
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + IL7Ralpha + Transmembrane Domain + 
       IL7Ralpha ICD

<400>  23

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser Gly Pro Ile Leu Leu Thr 
    130                 135                 140                 


Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala 
145                 150                 155                 160 


Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu 
                165                 170                 175     


Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys 
            180                 185                 190         


Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
        195                 200                 205             


His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu 
    210                 215                 220                 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
225                 230                 235                 240 


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
                245                 250                 255     


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
            260                 265                 270         


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
        275                 280                 285             


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
    290                 295                 300                 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
                325                 330                 335     


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
            340                 345                 350         


Ser Ser Phe Tyr Gln Asn Gln 
        355                 


<210>  24
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain + IL7Ralpha "CPT" Transmembrane Domain + 
       IL7Ralpha Intracellular Domain

<400>  24

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser Gly Pro Ile Leu Leu Thr 
    130                 135                 140                 


Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val 
145                 150                 155                 160 


Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp 
                165                 170                 175     


Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys 
            180                 185                 190         


Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp 
        195                 200                 205             


Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu 
    210                 215                 220                 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
225                 230                 235                 240 


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
                245                 250                 255     


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
            260                 265                 270         


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
        275                 280                 285             


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
    290                 295                 300                 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
305                 310                 315                 320 


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
                325                 330                 335     


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
            340                 345                 350         


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
        355                 360         


<210>  25
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF beta R2 signal sequence

<400>  25

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser 
            20          


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal sequence

<400>  26

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Myc tag

<400>  27

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


<210>  28
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Extracellular Domain

<400>  28

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
145                 150                 155                 


<210>  29
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha + Myc tag + Extracellular Domain

<400>  29

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
        35                  40                  45              


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
    50                  55                  60                  


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
65                  70                  75                  80  


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
                85                  90                  95      


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
            100                 105                 110         


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
        115                 120                 125             


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
    130                 135                 140                 


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
145                 150                 155                 160 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
                165                 


<210>  30
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha + Extracellular Domain + IL7Ralpha Transmembrane 
       Domain + IL7Ralpha Intracellular Domain

<400>  30

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
145                 150                 155                 160 


Gly Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala 
                165                 170                 175     


Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro 
            180                 185                 190         


Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu 
        195                 200                 205             


Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser 
    210                 215                 220                 


Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp 
225                 230                 235                 240 


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
                245                 250                 255     


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
            260                 265                 270         


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
        275                 280                 285             


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
    290                 295                 300                 


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
305                 310                 315                 320 


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
                325                 330                 335     


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
            340                 345                 350         


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
        355                 360                 365             


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    370                 375                 380     


<210>  31
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Myc tag + Extracellular Domain + IL7Ralpha 
       Transmembrane Domain + IL7Ralpha Intracellular Domain

<400>  31

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
        35                  40                  45              


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
    50                  55                  60                  


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
65                  70                  75                  80  


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
                85                  90                  95      


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
            100                 105                 110         


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
        115                 120                 125             


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
    130                 135                 140                 


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
145                 150                 155                 160 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser Gly Pro Ile Leu Leu Thr 
                165                 170                 175     


Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala 
            180                 185                 190         


Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu 
        195                 200                 205             


Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys 
    210                 215                 220                 


Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
225                 230                 235                 240 


His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu 
                245                 250                 255     


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
            260                 265                 270         


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
        275                 280                 285             


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
    290                 295                 300                 


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
305                 310                 315                 320 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
                325                 330                 335     


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
            340                 345                 350         


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
        355                 360                 365             


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
    370                 375                 380                 


Ser Ser Phe Tyr Gln Asn Gln 
385                 390     


<210>  32
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha + Extracellular Domain + IL7Ralpha Transmembrane 
       Domain + IL7Ralpha Intracellular Domain

<400>  32

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
145                 150                 155                 160 


Gly Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala 
                165                 170                 175     


Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro 
            180                 185                 190         


Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu 
        195                 200                 205             


Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser 
    210                 215                 220                 


Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp 
225                 230                 235                 240 


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
                245                 250                 255     


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
            260                 265                 270         


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
        275                 280                 285             


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
    290                 295                 300                 


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
305                 310                 315                 320 


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
                325                 330                 335     


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
            340                 345                 350         


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
        355                 360                 365             


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    370                 375                 380     


<210>  33
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Myc tag + Extracellular Domain + IL7Ralpha 
       "CPT" Transmembrane Domain + IL7Ralpha Intracellular Domain

<400>  33

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
        35                  40                  45              


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
    50                  55                  60                  


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
65                  70                  75                  80  


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
                85                  90                  95      


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
            100                 105                 110         


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
        115                 120                 125             


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
    130                 135                 140                 


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
145                 150                 155                 160 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser Gly Pro Ile Leu Leu Thr 
                165                 170                 175     


Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val 
            180                 185                 190         


Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp 
        195                 200                 205             


Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys 
    210                 215                 220                 


Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp 
225                 230                 235                 240 


Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu 
                245                 250                 255     


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
            260                 265                 270         


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
        275                 280                 285             


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
    290                 295                 300                 


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
305                 310                 315                 320 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
                325                 330                 335     


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
            340                 345                 350         


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
        355                 360                 365             


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
    370                 375                 380                 


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
385                 390                 


<210>  34
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Extracellular Domain + IL7Ralpha "CPT" 
       Transmembrane Domain + IL7Ralpha Intracellular Domain

<400>  34

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
145                 150                 155                 160 


Gly Pro Ile Leu Leu Thr Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe 
                165                 170                 175     


Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg 
            180                 185                 190         


Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu 
        195                 200                 205             


Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn 
    210                 215                 220                 


Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
225                 230                 235                 240 


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
                245                 250                 255     


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
            260                 265                 270         


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
        275                 280                 285             


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
    290                 295                 300                 


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
305                 310                 315                 320 


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
                325                 330                 335     


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
            340                 345                 350         


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
        355                 360                 365             


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    370                 375                 380                 


<210>  35
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Myc tag + Extracellular Domain + IL7Ralpha 
       Transmembrane Domain

<400>  35
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc cttcctgctg       60

atccccgagc agaagctgat cagcgaggag gacctgacca tcccccccca cgtgcagaag      120

agcgtgaaca acgacatgat cgtgaccgac aacaacggcg ccgtgaagtt cccccagctg      180

tgcaagttct gcgacgtgag gttcagcacc tgcgacaacc agaagagctg catgagcaac      240

tgcagcatca ccagcatctg cgagaagccc caggaggtgt gcgtggccgt gtggaggaag      300

aacgacgaga acatcaccct ggagaccgtg tgccacgacc ccaagctgcc ctaccacgac      360

ttcatcctgg aggacgccgc cagccccaag tgcatcatga aggagaagaa gaagcccggc      420

gagaccttct tcatgtgcag ctgcagcagc gacgagtgca acgacaacat catcttcagc      480

gaggagtaca acaccagcaa ccccgacccc agccccatcc tgctgaccat cagcatcctg      540

agcttcttca gcgtggccct gctggtgatc ctg                                   573


<210>  36
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CSF2Ralpha signal + Myc tag + Extracellular Domain + IL7Ralpha 
       "CPT" Transmembrane Domain

<400>  36
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc cttcctgctg       60

atccccgagc agaagctgat cagcgaggag gacctgacca tcccccccca cgtgcagaag      120

agcgtgaaca acgacatgat cgtgaccgac aacaacggcg ccgtgaagtt cccccagctg      180

tgcaagttct gcgacgtgag gttcagcacc tgcgacaacc agaagagctg catgagcaac      240

tgcagcatca ccagcatctg cgagaagccc caggaggtgt gcgtggccgt gtggaggaag      300

aacgacgaga acatcaccct ggagaccgtg tgccacgacc ccaagctgcc ctaccacgac      360

ttcatcctgg aggacgccgc cagccccaag tgcatcatga aggagaagaa gaagcccggc      420

gagaccttct tcatgtgcag ctgcagcagc gacgagtgca acgacaacat catcttcagc      480

gaggagtaca acaccagcaa ccccgacccc agcggcatcc tgctgacctg ccccaccatc      540

agcatcctga gcttcttcag cgtggccctg ctggtgatcc tg                         582


<210>  37
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  37

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
305                 310                 315                 320 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                325                 330                 335     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            340                 345                 350         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                405                 410                 415     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            420                 425                 430         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        435                 440                 445             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    450                 455                 460                 


Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470             


<210>  38
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Artificial Sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  39
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  40

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  41
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  41

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  42
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  42

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  43
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  43

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  44
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  44

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40      


<210>  45
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  45

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Ile Val Met Thr Gln 
1               5                   10                  15      


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
            20                  25                  30          


Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
        35                  40                  45              


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
    50                  55                  60                  


Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
                85                  90                  95      


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu 
            100                 105                 110         


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn Ala Met Asn 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile 
            180                 185                 190         


Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
225                 230                 235                 240 


Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  46

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  47
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
305                 310                 315                 320 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                325                 330                 335     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            340                 345                 350         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                405                 410                 415     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            420                 425                 430         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        435                 440                 445             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    450                 455                 460                 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly 
                485                 490                 495     


Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr 
            500                 505                 510         


Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
        515                 520                 525             


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
    530                 535                 540                 


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
545                 550                 555                 560 


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
                565                 570                 575     


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
            580                 585                 590         


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
        595                 600                 605             


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
    610                 615                 620                 


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
625                 630                 635                 640 


Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu 
                645                 650                 655     


Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val 
            660                 665                 670         


Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln 
        675                 680                 685             


<210>  48
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  48
atgggcaggg gcctgctgag gggcctgtgg cccctgcaca tcgtgctgtg gaccaggatc       60

gccagcacca tcccccccca cgtgcagaag agcgtgaaca acgacatgat cgtgaccgac      120

aacaacggcg ccgtgaagtt cccccagctg tgcaagttct gcgacgtgag gttcagcacc      180

tgcgacaacc agaagagctg catgagcaac tgcagcatca ccagcatctg cgagaagccc      240

caggaggtgt gcgtggccgt gtggaggaag aacgacgaga acatcaccct ggagaccgtg      300

tgccacgacc ccaagctgcc ctaccacgac ttcatcctgg aggacgccgc cagccccaag      360

tgcatcatga aggagaagaa gaagcccggc gagaccttct tcatgtgcag ctgcagcagc      420

gacgagtgca acgacaacat catcttcagc gaggagtaca acaccagcaa ccccgacctg      480

ctgctggtga tcttccaggt gaccggcatc agcctgctgc cccccctggg cgtggccatc      540

agcgtgatca tcatcttcta ctgctacagg gtgaacaggc ag                         582


<210>  49
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  49
gagcagaagc tgatcagcga ggaggacctc gatatcgtga tgacccagag ccccgactct       60

ttagctgtgt ctttaggaga gagggccaca atcaactgca agagcagcca gagcctcctc      120

tacagcagca accagaagaa ctatttagct tggtaccagc aaaagcccgg ccagcccccc      180

aagctgctga tctactgggc cagcagcaga gagagcggcg tgcccgatag attcagcgga      240

agcggctccg gcacagattt caccctcacc attagctctt tacaagctga ggacgtggcc      300

gtgtactact gccagcagta ctacaactac cctttaacct tcggccaagg taccaagctg      360

gagatcaagg gctccacatc cggatccggc aagcccggta gcggagaagg cagcacaaag      420

ggagaggtgc agctggtgga gagcggaggc ggactggtcc agcccggtgg atctttaagg      480

ctgtcttgtg ccgccagcgg ctttaccttt aacaagaacg ctatgaactg ggtgaggcaa      540

gctcccggta agggtttaga gtgggtgggt cgtattcgta ataagaccaa caactacgcc      600

acctactatg ccgactccgt gaaggctcgt ttcaccatct ctcgtgacga cagcaagaac      660

agcctctatt tacagatgaa ctctttaaag accgaggaca ccgccgtgta ctattgcgtg      720

gctggcaact ccttcgccta ctggggccaa ggcactttag tgaccgtgag ctccgggtcc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      960

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1020

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1080

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1140

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1200

gaggagtacg atgttttgga caagaggcgt ggccgggacc ctgagatggg gggaaagccg     1260

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1320

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1380

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1440

ccccctcgc                                                             1449


<210>  50
<211>  2094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  50
gagcagaagc tgatcagcga ggaggacctc gatatcgtga tgacccagag ccccgactct       60

ttagctgtgt ctttaggaga gagggccaca atcaactgca agagcagcca gagcctcctc      120

tacagcagca accagaagaa ctatttagct tggtaccagc aaaagcccgg ccagcccccc      180

aagctgctga tctactgggc cagcagcaga gagagcggcg tgcccgatag attcagcgga      240

agcggctccg gcacagattt caccctcacc attagctctt tacaagctga ggacgtggcc      300

gtgtactact gccagcagta ctacaactac cctttaacct tcggccaagg taccaagctg      360

gagatcaagg gctccacatc cggatccggc aagcccggta gcggagaagg cagcacaaag      420

ggagaggtgc agctggtgga gagcggaggc ggactggtcc agcccggtgg atctttaagg      480

ctgtcttgtg ccgccagcgg ctttaccttt aacaagaacg ctatgaactg ggtgaggcaa      540

gctcccggta agggtttaga gtgggtgggt cgtattcgta ataagaccaa caactacgcc      600

acctactatg ccgactccgt gaaggctcgt ttcaccatct ctcgtgacga cagcaagaac      660

agcctctatt tacagatgaa ctctttaaag accgaggaca ccgccgtgta ctattgcgtg      720

gctggcaact ccttcgccta ctggggccaa ggcactttag tgaccgtgag ctccgggtcc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      960

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1020

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1080

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1140

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1200

gaggagtacg atgttttgga caagaggcgt ggccgggacc ctgagatggg gggaaagccg     1260

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1320

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1380

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1440

ccccctcgcg gctctggaga gggcagaggc tctctgctga cctgcggcga cgtggaagag     1500

aacccaggcc ccatgggaag aggtttactg agaggactgt ggcctttaca catcgtgctg     1560

tggactcgta tcgccagcac catccccccc catgtgcaga agagcgtgaa caacgacatg     1620

atcgtgaccg acaacaatgg cgccgtgaag ttcccccagc tgtgcaagtt ctgcgacgtg     1680

aggttcagca cttgtgacaa ccagaagagc tgcatgagca actgcagcat cacctccatc     1740

tgcgagaagc cccaagaagt gtgcgtggcc gtgtggagga agaacgacga gaacatcact     1800

ttagagacag tgtgccacga ccccaagctg ccctaccacg acttcatttt agaagatgcc     1860

gccagcccca agtgcatcat gaaggagaag aagaagcccg gcgagacctt cttcatgtgc     1920

agctgcagct ccgacgagtg caacgataac atcatcttca gcgaggagta caacaccagc     1980

aaccccgatt tactgctggt gatcttccaa gttaccggca tttctttact gcctccttta     2040

ggcgtggcta tcagcgtgat catcatcttc tactgctata gggtgaacag acag           2094


<210>  51
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  51
gatatcgtga tgacccagag ccccgactct ttagctgtga gccttggaga gagggccaca       60

atcaactgca agagcagcca gagcctcctc tacagcagca accagaagaa ctatttagct      120

tggtaccagc aaaagcccgg ccagcccccc aagctgctga tctactgggc cagcagcaga      180

gagagcggcg tgcccgatag attcagcgga agcggctccg gcacagattt caccctcacc      240

attagctctt tacaagctga ggacgtggcc gtgtactact gccagcagta ctacaactac      300

cctttaacct tcggccaagg aacaaagctg gagatcaagg gctccacatc cggatccggc      360

aagcccggta gcggagaagg cagcacaaag ggagaggtgc agctggtgga gagcggaggc      420

ggactggtcc agcccggtgg atctttaagg ctgtcttgtg ccgccagcgg ctttaccttt      480

aacaagaacg ctatgaactg ggtccgacaa gctcccggaa aaggtttaga gtgggtgggt      540

cgtattcgta ataagaccaa caactacgcc acctactatg ccgactccgt gaaggctcgt      600

ttcaccatct ctcgtgacga cagcaagaac agcctctatt tacaaatgaa ctctttaaag      660

accgaggaca ccgccgtgta ctattgcgtg gctggcaact ccttcgccta ctggggccaa      720

ggcactttag tgaccgtgag ctccgggtcc accacgacgc cagcgccgcg accaccaaca      780

ccggcgccca ccatcgcgtc gcaacccctg tccctgcgcc ccgaggcgtg ccggccagcg      840

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      900

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttattgcaaa      960

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1020

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1080

ttgagagtga agttcagcag gagcgcagac gcccccgcct atcagcaagg ccagaaccag     1140

ctctataacg agctcaattt agggcgaaga gaggagtacg atgttttgga caagaggcgt     1200

ggccgggacc ccgaaatggg gggaaagccg agaaggaaga accctcagga aggcttgtac     1260

aatgaattgc agaaggataa gatggcggag gcatacagtg agattgggat gaaaggcgag     1320

cgccggaggg gcaaggggca cgatggcctt tatcagggtc tcagtacagc caccaaggac     1380

acctacgacg cccttcacat gcaagccctg ccccctcgc                            1419


<210>  52
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  52
gatatcgtga tgacccagag ccccgactct ttagctgtga gccttggaga gagggccaca       60

atcaactgca agagcagcca gagcctcctc tacagcagca accagaagaa ctatttagct      120

tggtaccagc aaaagcccgg ccagcccccc aagctgctga tctactgggc cagcagcaga      180

gagagcggcg tgcccgatag attcagcgga agcggctccg gcacagattt caccctcacc      240

attagctctt tacaagctga ggacgtggcc gtgtactact gccagcagta ctacaactac      300

cctttaacct tcggccaagg aacaaagctg gagatcaagg gctccacatc cggatccggc      360

aagcccggta gcggagaagg cagcacaaag ggagaggtgc agctggtgga gagcggaggc      420

ggactggtcc agcccggtgg atctttaagg ctgtcttgtg ccgccagcgg ctttaccttt      480

aacaagaacg ctatgaactg ggtccgacaa gctcccggaa aaggtttaga gtgggtgggt      540

cgtattcgta ataagaccaa caactacgcc acctactatg ccgactccgt gaaggctcgt      600

ttcaccatct ctcgtgacga cagcaagaac agcctctatt tacaaatgaa ctctttaaag      660

accgaggaca ccgccgtgta ctattgcgtg gctggcaact ccttcgccta ctggggccaa      720

ggcactttag tgaccgtgag ctccgggtcc accacgacgc cagcgccgcg accaccaaca      780

ccggcgccca ccatcgcgtc gcaacccctg tccctgcgcc ccgaggcgtg ccggccagcg      840

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      900

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttattgcaaa      960

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1020

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1080

ttgagagtga agttcagcag gagcgcagac gcccccgcct atcagcaagg ccagaaccag     1140

ctctataacg agctcaattt agggcgaaga gaggagtacg atgttttgga caagaggcgt     1200

ggccgggacc ccgaaatggg gggaaagccg agaaggaaga accctcagga aggcttgtac     1260

aatgaattgc agaaggataa gatggcggag gcatacagtg agattgggat gaaaggcgag     1320

cgccggaggg gcaaggggca cgatggcctt tatcagggtc tcagtacagc caccaaggac     1380

acctacgacg cccttcacat gcaagccctg ccccctcgcg gctctggaga gggcagaggc     1440

tctctgctga cctgcggcga cgtggaagag aacccaggcc ccatgggaag aggtttactg     1500

agaggactgt ggcctttaca catcgtgctg tggactcgta tcgccagcac catccccccc     1560

catgtccaaa agagcgtgaa caacgacatg atcgtgaccg acaacaatgg cgccgtgaag     1620

ttcccccagc tgtgcaagtt ctgcgacgtg aggttcagca cttgtgacaa ccagaagagc     1680

tgcatgagca actgcagcat cacctccatc tgcgagaagc cccaagaagt gtgcgtggcc     1740

gtgtggagga agaacgacga gaacatcact ttagagacag tgtgccacga ccccaagctg     1800

ccctaccacg acttcatttt agaagatgcc gccagcccca agtgcatcat gaaggagaag     1860

aagaagcccg gcgagacctt cttcatgtgt tcttgttcgt ctgatgagtg caacgataac     1920

atcatcttca gcgaggagta caacaccagc aaccccgatt tactgctggt gatcttccaa     1980

gttaccggca tttctttact gcctccgttg ggcgtggcta tcagcgtgat catcatcttc     2040

tactgctatc gtgttaatcg tcaa                                            2064


<210>  53
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  53
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacata tggaggtgca gcttgttgag tctggtggag gattggtgca gcctggaggg      120

tcattgagac tctcatgtgc agcctctgga ttcaccttca ataagaatgc catgaattgg      180

gtccgccagg ctccaggaaa gggtttggaa tgggttggcc gcataagaaa taaaactaat      240

aattatgcaa catattatgc cgattcagtg aaagccaggt ttaccatctc cagagatgat      300

tcaaagaact cactctatct gcaaatgaac agcttgaaaa ccgaggacac agccgtgtac      360

tattgtgtgg ctggtaactc gtttgcttac tggggccaag ggactctggt cactgtctct      420

gcaggcggag gcggatcagg tggtggcgga tctggaggtg gcggaagcga cattgtgatg      480

acccagtctc cagactccct agctgtgtca ctgggagaga gggccactat caactgcaag      540

tccagtcaga gccttttata tagcagcaat caaaagaact acttggcctg gtaccaacag      600

aaaccagggc agcctcctaa actgctgatt tactgggcat ccagtaggga atctggggtc      660

cctgatcgct tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      720

caggctgaag acgtggcagt ttattactgt cagcaatatt ataactatcc gctcacgttc      780

ggtcagggga ccaagttgga gatcaaaact agtaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgacat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctga                               1476


<210>  54
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  54
atgcttctcc tggtgacaag ccttctgctc tgcgaattac cacacccagc attcctcctg       60

atcccacata tggaggtgca gcttgttgag tctggtggag gattggtgca gcctggaggg      120

tcattgagac tctcatgtgc agcctctgga ttcaccttca ataagaatgc catgaattgg      180

gtccgccagg ctccaggaaa gggtttggaa tgggttggcc gcataagaaa taaaactaat      240

aattatgcaa catattatgc cgattcagtg aaagccaggt ttaccatctc cagagatgat      300

tcaaagaact cactctatct gcaaatgaac agcttgaaaa ccgaggacac agccgtgtac      360

tattgtgtgg ctggaaactc gtttgcttac tggggccaag ggactctggt cactgtcagc      420

gctggaggag gcggatcagg tggtggcgga tctggaggtg gcggaagcga cattgtgatg      480

acccagtctc cagactccct agctgtgtca ctgggagaga gggccactat caactgcaag      540

tccagtcaga gccttttata tagcagcaat caaaagaact acttggcctg gtaccagcaa      600

aagccagggc agcctcctaa actgctgatt tactgggcat ccagtaggga atctggggtc      660

cctgatcgct tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      720

caggctgaag acgtggcagt ttattactgt cagcaatatt ataactatcc gctcacgttc      780

ggtcagggga ccaagttgga gatcaaaact agtaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gagtcaacca ctgtccctga ggcctgaagc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgacat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc aagggcagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag gcgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaagc tctgccccct cgctga                               1476


<210>  55
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  55
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacata tggaggtgca gcttgttgag tctggtggag gattggtgca gcctggaggg      120

tcattgagac tctcatgtgc agcctctgga ttcaccttca ataagaatgc catgaattgg      180

gtccgccagg ctccaggaaa gggtttggaa tgggttggcc gcataagaaa taaaactaat      240

aattatgcaa catattatgc cgattcagtg aaagccaggt ttaccatctc cagagatgat      300

tcaaagaact cactctatct gcaaatgaac agcttgaaaa ccgaggacac agccgtgtac      360

tattgtgtgg ctggtaactc gtttgcttac tggggccaag ggactctggt cactgtctct      420

gcaggcggag gcggatcagg tggtggcgga tctggaggtg gcggaagcga cattgtgatg      480

acccagtctc cagactccct agctgtgtca ctgggagaga gggccactat caactgcaag      540

tccagtcaga gccttttata tagcagcaat caaaagaact acttggcctg gtaccaacag      600

aaaccagggc agcctcctaa actgctgatt tactgggcat ccagtaggga atctggggtc      660

cctgatcgct tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      720

caggctgaag acgtggcagt ttattactgt cagcaatatt ataactatcc gctcacgttc      780

ggtcagggga ccaagttgga gatcaaaact agtaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgacat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgcgagggca gaggctctct gctgacctgc     1500

ggcgacgtgg aagagaaccc aggccccatg ggaagaggtt tactgagagg actgtggcct     1560

ttacacatcg tgctgtggac tcgtatcgcc agcaccatcc ccccccatgt ccaaaagagc     1620

gtgaacaacg acatgatcgt gaccgacaac aatggcgccg tgaagttccc ccagctgtgc     1680

aagttctgcg acgtgaggtt cagcacttgt gacaaccaga agagctgcat gagcaactgc     1740

agcatcacct ccatctgcga gaagccccaa gaagtgtgcg tggccgtgtg gaggaagaac     1800

gacgagaaca tcactttaga gacagtgtgc cacgacccca agctgcccta ccacgacttc     1860

attttagaag atgccgccag ccccaagtgc atcatgaagg agaagaagaa gcccggcgag     1920

accttcttca tgtgttcttg ttcgtctgat gagtgcaacg ataacatcat cttcagcgag     1980

gagtacaaca ccagcaaccc cgatttactg ctggtgatct tccaagttac cggcatttct     2040

ttactgcctc cgttgggcgt ggctatcagc gtgatcatca tcttctactg ctatcgtgtt     2100

aatcgtcaat ga                                                         2112


<210>  56
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  56

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro His Met Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn 
65                  70                  75                  80  


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
                165                 170                 175     


Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  57
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  57

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro His Met Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn 
65                  70                  75                  80  


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
                165                 170                 175     


Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  58
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  58

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro His Met Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn 
65                  70                  75                  80  


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
                165                 170                 175     


Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


