                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF MAPLE SYRUP URINE 
       DISEASE

<130>  UPN-19-8935PCT

<150>  62/864263
<151>  2019-06-20

<150>  63/016240
<151>  2020-04-27

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  482
<212>  PRT
<213>  Homo sapiens


<220>
<221>  TRANSIT
<222>  (1)..(61)

<220>
<221>  MISC_FEATURE
<222>  (62)..(482)
<223>  mature chain

<400>  1

Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys 
1               5                   10                  15      


Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu 
            20                  25                  30          


Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser 
        35                  40                  45              


His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val 
    50                  55                  60                  


Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr 
65                  70                  75                  80  


Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp 
                85                  90                  95      


Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser 
            100                 105                 110         


Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile 
        115                 120                 125             


Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys 
    130                 135                 140                 


Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu 
145                 150                 155                 160 


His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala 
                165                 170                 175     


Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val 
            180                 185                 190         


Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr 
        195                 200                 205             


Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu 
    210                 215                 220                 


Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu 
225                 230                 235                 240 


Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile 
                245                 250                 255     


Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys 
            260                 265                 270         


Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val 
        275                 280                 285             


Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys 
    290                 295                 300                 


Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu 
305                 310                 315                 320 


Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile 
                325                 330                 335     


Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln 
            340                 345                 350         


Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe 
        355                 360                 365             


Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly 
    370                 375                 380                 


Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn 
385                 390                 395                 400 


Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro 
                405                 410                 415     


Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe 
            420                 425                 430         


Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp 
        435                 440                 445             


Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser 
    450                 455                 460                 


Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp 
465                 470                 475                 480 


Leu Lys 
        


<210>  2
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered E2 coding sequence

<400>  2
atggccgccg tcagaatgct gagaacctgg tccagaaacg ccggcaagct gatctgcgtg       60

cggtactttc agacctgcgg caatgtgcac gtgctgaagc ccaactacgt gtgcttcttc      120

ggctacccca gcttcaagta ctctcaccct caccactttc tcaagaccac cgccgctctg      180

agaggacagg tggtgcagtt caagctgagc gacatcggcg agggcatcag agaagtgacc      240

gtgaaagagt ggtacgtcaa agagggcgac accgtcagcc agttcgacag catctgtgaa      300

gtgcagagcg acaaggccag cgtgaccatc accagcagat acgacggcgt gatcaagaag      360

ctgtactaca acctggacga tatcgcctac gtgggcaagc ccctggtgga cattgaaaca      420

gaggccctga aggacagcga agaggacgtg gtggaaaccc ctgccgtgtc tcacgacgag      480

cacacccacc aagagatcaa gggcagaaag accctggcca caccagctgt tagacggctg      540

gccatggaaa acaacatcaa gctgtccgag gtcgtcggca gcggcaagga tggcagaatc      600

ctgaaagagg acatcctgaa ctacctcgag aagcagaccg gcgccatcct gcctccatct      660

ccaaaggtgg aaatcatgcc tcctccacct aagcctaagg acatgaccgt gcctatcctg      720

gtgtccaagc ctcctgtgtt caccggcaag gacaagaccg agccaatcaa gggcttccag      780

aaagccatgg tcaagaccat gagcgctgcc ctgaagatcc ctcactttgg ctactgcgac      840

gagatcgacc tgaccgagct ggttaagctg agagaggaac tgaagcctat cgccttcgcc      900

agaggcatca aactgagctt catgccgttc tttctgaagg ccgcctctct gggcctgctg      960

cagttcccta ttctgaacgc cagcgtggac gagaactgcc agaacatcac ctacaaggcc     1020

tctcacaaca tcggaatcgc catggacaca gagcagggcc tgatcgtgcc caacgtgaag     1080

aacgtgcaga tttgctccat cttcgacatt gccaccgagc tgaaccggct gcagaaactg     1140

ggatctgtgg gccagctgag caccaccgat cttacaggcg gcaccttcac actgtccaac     1200

atcggctcta tcggcggcac attcgccaag cctgtgatca tgccaccaga ggtggccatt     1260

ggagccctgg gcagcattaa ggccattcct cggttcaacc agaaaggcga ggtgtacaag     1320

gcccagatca tgaacgtgtc ttggagcgcc gaccacagag tgatcgatgg cgccaccatg     1380

agcagattca gcaacctgtg gaagtcctac ctggaaaacc ccgccttcat gctgctggac     1440

ctgaagtga                                                             1449


<210>  3
<211>  1339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic sequence encoding human E1A


<220>
<221>  CDS
<222>  (1)..(1338)

<400>  3
atg gct gtg gct att gct gct gcc aga gtg tgg cgg ctg aat aga gga         48
Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly           
1               5                   10                  15                

ctg tct cag gct gct ctg ctg ctg ctg aga caa cct ggt gca aga gga         96
Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly           
            20                  25                  30                    

ctg gcc aga agc cat cct cct aga cag cag caa cag ttc agc agc ctg        144
Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser Ser Leu           
        35                  40                  45                        

gac gac aag cct cag ttt cct ggc gcc tcc gcc gag ttc atc gac aag        192
Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile Asp Lys           
    50                  55                  60                            

ctg gaa ttc atc cag cct aac gtg atc agc ggc atc ccc atc tac aga        240
Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg           
65                  70                  75                  80            

gtg atg gac aga cag ggc cag atc atc aac ccc agc gag gac cct cac        288
Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His           
                85                  90                  95                

ctg ccc aaa gaa aag gtg ctg aag ctg tac aag agc atg acc ctg ctg        336
Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr Leu Leu           
            100                 105                 110                   

aac aca atg gac cgg atc ctg tac gag agc cag aga cag ggc aga atc        384
Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile           
        115                 120                 125                       

agc ttc tac atg acc aac tac ggc gaa gag ggc aca cac gtg gga tct        432
Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser           
    130                 135                 140                           

gct gcc gct ctg gac aac acc gac ctg gtg ttt ggc cag tac aga gaa        480
Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu           
145                 150                 155                 160           

gcc ggc gtg ctg atg tac cgg gac tac cct ctg gaa ctg ttc atg gcc        528
Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala           
                165                 170                 175               

cag tgc tac ggc aac atc agc gac ctc gga aag ggc aga cag atg cct        576
Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln Met Pro           
            180                 185                 190                   

gtg cac tac ggc tgc aaa gaa cgg cac ttc gtg acc atc agc agc cct        624
Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro           
        195                 200                 205                       

ctg gcc aca cag att cct cag gct gtg gga gcc gcc tac gcc gcc aaa        672
Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys           
    210                 215                 220                           

aga gcc aac gcc aac aga gtg gtc atc tgc tac ttt ggc gag ggc gct        720
Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu Gly Ala           
225                 230                 235                 240           

gct tct gaa ggc gac gct cac gcc ggc ttc aat ttc gcc gcc act ctg        768
Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu           
                245                 250                 255               

gag tgc ccc atc atc ttt ttc tgc cgg aac aac ggc tac gcc atc agc        816
Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser           
            260                 265                 270                   

aca cct acc agc gag cag tat aga ggc gac gga att gcc gcc aga gga        864
Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly           
        275                 280                 285                       

cct ggc tat ggc atc atg agc atc aga gtg gac ggc aac gac gtg ttc        912
Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe           
    290                 295                 300                           

gcc gtg tac aac gcc acc aaa gaa gcc agg cgg aga gcc gtg gct gag        960
Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu           
305                 310                 315                 320           

aac cag cct ttt ctg atc gag gcc atg acc tac cgg atc ggc cac cac       1008
Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His           
                325                 330                 335               

agc acc tcc gac gat agc agc gcc tac aga tcc gtg gac gaa gtg aac       1056
Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn           
            340                 345                 350                   

tac tgg gac aag cag gat cac ccc atc tcc aga ctg cgg cac tac ctg       1104
Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His Tyr Leu           
        355                 360                 365                       

ctg tct caa ggc tgg tgg gac gaa gaa caa gag aag gcc tgg cgg aag       1152
Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys           
    370                 375                 380                           

cag agc cgg cgg aaa gtg atg gaa gcc ttt gag cag gcc gag cgg aag       1200
Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys           
385                 390                 395                 400           

ccc aag cct aat cct aac ctg ctg ttc agc gac gtg tac caa gag atg       1248
Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln Glu Met           
                405                 410                 415               

cct gct cag ctg cgc aag cag caa gaa agc ctg gcc aga cac ctg cag       1296
Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His Leu Gln           
            420                 425                 430                   

acc tac ggc gag cac tac cca ctg gac cac ttc gac aaa tga t             1339
Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys                       
        435                 440                 445                       


<210>  4
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly 
1               5                   10                  15      


Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly 
            20                  25                  30          


Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser Ser Leu 
        35                  40                  45              


Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile Asp Lys 
    50                  55                  60                  


Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg 
65                  70                  75                  80  


Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His 
                85                  90                  95      


Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr Leu Leu 
            100                 105                 110         


Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile 
        115                 120                 125             


Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser 
    130                 135                 140                 


Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu 
145                 150                 155                 160 


Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala 
                165                 170                 175     


Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln Met Pro 
            180                 185                 190         


Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro 
        195                 200                 205             


Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys 
    210                 215                 220                 


Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu Gly Ala 
225                 230                 235                 240 


Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu 
                245                 250                 255     


Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser 
            260                 265                 270         


Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly 
        275                 280                 285             


Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe 
    290                 295                 300                 


Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu 
305                 310                 315                 320 


Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His 
                325                 330                 335     


Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn 
            340                 345                 350         


Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His Tyr Leu 
        355                 360                 365             


Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys 
    370                 375                 380                 


Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys 
385                 390                 395                 400 


Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln Glu Met 
                405                 410                 415     


Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His Leu Gln 
            420                 425                 430         


Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys 
        435                 440                 445 


<210>  5
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered sequence encoding human E1B subunit protein


<220>
<221>  CDS
<222>  (1)..(1182)

<400>  5
atg gct gtt gtt gct gct gca gct gga tgg ctg ctg aga ctt aga gct         48
Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala           
1               5                   10                  15                

gct ggc gcc gaa ggc cat tgg aga agg ttg cct ggt gct gga ctg gcc         96
Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala           
            20                  25                  30                    

aga ggc ttt ctg cat cct gcc gcc aca gtg gaa gac gcc gct cag aga        144
Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg           
        35                  40                  45                        

agg cag gtc gcc cac ttc acc ttc cag cct gat cct gag cct aga gag        192
Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu           
    50                  55                  60                            

tac ggc cag aca cag aag atg aac ctg ttc cag agc gtg aca agc gcc        240
Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala           
65                  70                  75                  80            

ctg gac aac agc ctg gcc aaa gat cct acc gcc gtg atc ttc gga gag        288
Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu           
                85                  90                  95                

gac gtg gca ttc ggc ggc gtg ttc aga tgt aca gtg ggc ctg aga gat        336
Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp           
            100                 105                 110                   

aag tac ggc aag gac cgg gtg ttc aac aca ccc ctg tgt gaa cag ggc        384
Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly           
        115                 120                 125                       

atc gtc ggc ttc gga atc gga att gct gtg aca ggc gcc acc gcc att        432
Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile           
    130                 135                 140                           

gcc gag att cag ttc gcc gac tac atc ttc ccc gcc ttc gac cag atc        480
Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile           
145                 150                 155                 160           

gtg aac gag gcc gcc aag tac aga tac aga agc ggc gac ctg ttc aac        528
Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn           
                165                 170                 175               

tgc ggc agc ctg acc att aga agc cct tgg ggc tgt gtt gga cac ggc        576
Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly           
            180                 185                 190                   

gcc ctg tat cac tct cag agc cct gag gcc ttc ttc gcc cac tgt cct        624
Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro           
        195                 200                 205                       

ggc atc aag gtg gtc atc cct aga agc ccc ttt cag gcc aag ggc ctg        672
Gly Ile Lys Val Val Ile Pro Arg Ser Pro Phe Gln Ala Lys Gly Leu           
    210                 215                 220                           

ctg ctg tcc tgc atc gag gac aag aac ccc tgc atc ttc ttc gag ccc        720
Leu Leu Ser Cys Ile Glu Asp Lys Asn Pro Cys Ile Phe Phe Glu Pro           
225                 230                 235                 240           

aag atc ctg tac cgg gct gcc gct gag gaa gtg cct atc gag ccc tac        768
Lys Ile Leu Tyr Arg Ala Ala Ala Glu Glu Val Pro Ile Glu Pro Tyr           
                245                 250                 255               

aac atc cct ctg agc cag gcc gaa gtg atc caa gag ggc tcc gat gtg        816
Asn Ile Pro Leu Ser Gln Ala Glu Val Ile Gln Glu Gly Ser Asp Val           
            260                 265                 270                   

aca ctg gtg gcc tgg gga aca cag gtg cac gtg atc aga gaa gtg gcc        864
Thr Leu Val Ala Trp Gly Thr Gln Val His Val Ile Arg Glu Val Ala           
        275                 280                 285                       

agc atg gct aaa gag aag ctg ggc gtc agc tgt gaa gtg atc gac ctg        912
Ser Met Ala Lys Glu Lys Leu Gly Val Ser Cys Glu Val Ile Asp Leu           
    290                 295                 300                           

aga aca atc atc ccc tgg gac gtc gac acc atc tgc aag tcc gtg atc        960
Arg Thr Ile Ile Pro Trp Asp Val Asp Thr Ile Cys Lys Ser Val Ile           
305                 310                 315                 320           

aag acc ggc aga ctg ctg atc tct cac gag gct cct ctg aca ggc ggc       1008
Lys Thr Gly Arg Leu Leu Ile Ser His Glu Ala Pro Leu Thr Gly Gly           
                325                 330                 335               

ttt gcc tct gag atc agc tcc acc gtg caa gag gag tgc ttc ctg aac       1056
Phe Ala Ser Glu Ile Ser Ser Thr Val Gln Glu Glu Cys Phe Leu Asn           
            340                 345                 350                   

ctg gaa gcc cca atc agc aga gtg tgc ggc tac gac acc cct ttt cca       1104
Leu Glu Ala Pro Ile Ser Arg Val Cys Gly Tyr Asp Thr Pro Phe Pro           
        355                 360                 365                       

cac atc ttt gag ccc ttc tac atc ccc gac aag tgg aag tgc tac gac       1152
His Ile Phe Glu Pro Phe Tyr Ile Pro Asp Lys Trp Lys Cys Tyr Asp           
    370                 375                 380                           

gcc ctg cgg aag atg atc aac tac tga taa                               1182
Ala Leu Arg Lys Met Ile Asn Tyr                                           
385                 390                                                   


<210>  6
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu 
    50                  55                  60                  


Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala 
65                  70                  75                  80  


Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu 
                85                  90                  95      


Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp 
            100                 105                 110         


Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly 
        115                 120                 125             


Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile 
    130                 135                 140                 


Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile 
145                 150                 155                 160 


Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn 
                165                 170                 175     


Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly 
            180                 185                 190         


Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro 
        195                 200                 205             


Gly Ile Lys Val Val Ile Pro Arg Ser Pro Phe Gln Ala Lys Gly Leu 
    210                 215                 220                 


Leu Leu Ser Cys Ile Glu Asp Lys Asn Pro Cys Ile Phe Phe Glu Pro 
225                 230                 235                 240 


Lys Ile Leu Tyr Arg Ala Ala Ala Glu Glu Val Pro Ile Glu Pro Tyr 
                245                 250                 255     


Asn Ile Pro Leu Ser Gln Ala Glu Val Ile Gln Glu Gly Ser Asp Val 
            260                 265                 270         


Thr Leu Val Ala Trp Gly Thr Gln Val His Val Ile Arg Glu Val Ala 
        275                 280                 285             


Ser Met Ala Lys Glu Lys Leu Gly Val Ser Cys Glu Val Ile Asp Leu 
    290                 295                 300                 


Arg Thr Ile Ile Pro Trp Asp Val Asp Thr Ile Cys Lys Ser Val Ile 
305                 310                 315                 320 


Lys Thr Gly Arg Leu Leu Ile Ser His Glu Ala Pro Leu Thr Gly Gly 
                325                 330                 335     


Phe Ala Ser Glu Ile Ser Ser Thr Val Gln Glu Glu Cys Phe Leu Asn 
            340                 345                 350         


Leu Glu Ala Pro Ile Ser Arg Val Cys Gly Tyr Asp Thr Pro Phe Pro 
        355                 360                 365             


His Ile Phe Glu Pro Phe Tyr Ile Pro Asp Lys Trp Lys Cys Tyr Asp 
    370                 375                 380                 


Ala Leu Arg Lys Met Ile Asn Tyr 
385                 390         


<210>  7
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7 Promoter Sequence

<400>  7
tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc       60

caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg      120

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag      180

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc      240

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gg                         282


<210>  8
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI Intron sequence

<400>  8
tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc       60

caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg      120

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag      180

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc      240

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gg                         282


<210>  9
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 PolyA

<400>  9
cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat cg              232


<210>  10
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBG promoter

<400>  10
agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa tttctacaga       60

acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta aaaaactgcc      120

aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct tggtgctttt      180

gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact taaacccctc      240

cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat      300

cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg gttttgtaca      360

tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac taagagtgct      420

ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc tgagaga         477


<210>  11
<211>  542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  11
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cg                                                                     542


<210>  12
<211>  215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bovine growth hormone (BGH) polyA

<400>  12
gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc       60

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg      120

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg      180

gaggattggg aagacaatag caggcatgct gggga                                 215


<210>  13
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  alpha mic/bik

<400>  13
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc                            100


<210>  14
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 misc intron

<400>  14
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  15
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5' ITR w Deletion 22 bp

<400>  15
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcct                   108


<210>  16
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2R5 S

<400>  16
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcct                   108


<210>  17
<211>  146
<212>  DNA
<213>  Artificial sequence

<220>
<223>  shortened MCK promoter

<400>  17
cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct atataaccca       60

ggggcacagg ggctgccccc gggtcacggg gatcctctag acctccgaac ggtaagagcc      120

tagcatgtag aactggttac cctgca                                           146


<210>  18
<211>  697
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBG promoter with enhancer

<400>  18
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaga                               697


<210>  19
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promega intron sequence

<400>  19
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  20
<211>  3428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette


<220>
<221>  repeat_region
<222>  (1)..(168)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (211)..(907)
<223>  TBG promoter w/enhancers

<220>
<221>  enhancer
<222>  (211)..(310)
<223>  alpha mic/bik enhancer

<220>
<221>  enhancer
<222>  (317)..(416)
<223>  alpha mic/bik enhancer

<220>
<221>  Intron
<222>  (939)..(1071)
<223>  SV40 misc intron (Promega)

<220>
<221>  CDS
<222>  (1089)..(2426)
<223>  hE1Aco

<220>
<221>  misc_feature
<222>  (2449)..(2990)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (2997)..(3211)
<223>  BGH pA

<220>
<221>  misc_feature
<222>  (3253)..(3298)
<223>  Additional AAV sequences

<220>
<221>  repeat_region
<222>  (3261)..(3428)
<223>  3'ITR

<400>  20
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc aggttaattt ttaaaaagca gtcaaaagtc      240

caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat ctcaggagca      300

caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag tggcccttgg      360

cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa cattccagat      420

ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa      480

tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta      540

aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct      600

tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact      660

taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag      720

ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg      780

gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac      840

taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc      900

tgagagactg cagaagttgg tcgtgaggca ctgggcaggt aagtatcaag gttacaagac      960

aggtttaagg agaccaatag aaactgggct tgtcgagaca gagaagactc ttgcgtttct     1020

gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca ggtgtccagg     1080

cggccgcc atg gct gtg gct att gct gct gcc aga gtg tgg cgg ctg aat      1130
         Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn          
         1               5                   10                           

aga gga ctg tct cag gct gct ctg ctg ctg ctg aga caa cct ggt gca       1178
Arg Gly Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala           
15                  20                  25                  30            

aga gga ctg gcc aga agc cat cct cct aga cag cag caa cag ttc agc       1226
Arg Gly Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser           
                35                  40                  45                

agc ctg gac gac aag cct cag ttt cct ggc gcc tcc gcc gag ttc atc       1274
Ser Leu Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile           
            50                  55                  60                    

gac aag ctg gaa ttc atc cag cct aac gtg atc agc ggc atc ccc atc       1322
Asp Lys Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile           
        65                  70                  75                        

tac aga gtg atg gac aga cag ggc cag atc atc aac ccc agc gag gac       1370
Tyr Arg Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp           
    80                  85                  90                            

cct cac ctg ccc aaa gaa aag gtg ctg aag ctg tac aag agc atg acc       1418
Pro His Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr           
95                  100                 105                 110           

ctg ctg aac aca atg gac cgg atc ctg tac gag agc cag aga cag ggc       1466
Leu Leu Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly           
                115                 120                 125               

aga atc agc ttc tac atg acc aac tac ggc gaa gag ggc aca cac gtg       1514
Arg Ile Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val           
            130                 135                 140                   

gga tct gct gcc gct ctg gac aac acc gac ctg gtg ttt ggc cag tac       1562
Gly Ser Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr           
        145                 150                 155                       

aga gaa gcc ggc gtg ctg atg tac cgg gac tac cct ctg gaa ctg ttc       1610
Arg Glu Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe           
    160                 165                 170                           

atg gcc cag tgc tac ggc aac atc agc gac ctc gga aag ggc aga cag       1658
Met Ala Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln           
175                 180                 185                 190           

atg cct gtg cac tac ggc tgc aaa gaa cgg cac ttc gtg acc atc agc       1706
Met Pro Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser           
                195                 200                 205               

agc cct ctg gcc aca cag att cct cag gct gtg gga gcc gcc tac gcc       1754
Ser Pro Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala           
            210                 215                 220                   

gcc aaa aga gcc aac gcc aac aga gtg gtc atc tgc tac ttt ggc gag       1802
Ala Lys Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu           
        225                 230                 235                       

ggc gct gct tct gaa ggc gac gct cac gcc ggc ttc aat ttc gcc gcc       1850
Gly Ala Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala           
    240                 245                 250                           

act ctg gag tgc ccc atc atc ttt ttc tgc cgg aac aac ggc tac gcc       1898
Thr Leu Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala           
255                 260                 265                 270           

atc agc aca cct acc agc gag cag tat aga ggc gac gga att gcc gcc       1946
Ile Ser Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala           
                275                 280                 285               

aga gga cct ggc tat ggc atc atg agc atc aga gtg gac ggc aac gac       1994
Arg Gly Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp           
            290                 295                 300                   

gtg ttc gcc gtg tac aac gcc acc aaa gaa gcc agg cgg aga gcc gtg       2042
Val Phe Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val           
        305                 310                 315                       

gct gag aac cag cct ttt ctg atc gag gcc atg acc tac cgg atc ggc       2090
Ala Glu Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly           
    320                 325                 330                           

cac cac agc acc tcc gac gat agc agc gcc tac aga tcc gtg gac gaa       2138
His His Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu           
335                 340                 345                 350           

gtg aac tac tgg gac aag cag gat cac ccc atc tcc aga ctg cgg cac       2186
Val Asn Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His           
                355                 360                 365               

tac ctg ctg tct caa ggc tgg tgg gac gaa gaa caa gag aag gcc tgg       2234
Tyr Leu Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp           
            370                 375                 380                   

cgg aag cag agc cgg cgg aaa gtg atg gaa gcc ttt gag cag gcc gag       2282
Arg Lys Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu           
        385                 390                 395                       

cgg aag ccc aag cct aat cct aac ctg ctg ttc agc gac gtg tac caa       2330
Arg Lys Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln           
    400                 405                 410                           

gag atg cct gct cag ctg cgc aag cag caa gaa agc ctg gcc aga cac       2378
Glu Met Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His           
415                 420                 425                 430           

ctg cag acc tac ggc gag cac tac cca ctg gac cac ttc gac aaa tga       2426
Leu Gln Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys               
                435                 440                 445               

taaagatctg cccggccgat ccaatcaacc tctggattac aaaatttgtg aaagattgac     2486

tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt     2546

gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt     2606

gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt     2666

gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg     2726

gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg     2786

ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc     2846

atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt     2906

ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc     2966

tctgcggcct cttccgcgtc ttcgagatct gcctcgactg tgccttctag ttgccagcca     3026

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     3086

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     3146

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     3206

ggggactcga gttaagggcg aattcccgat aaggatcttc ctagagcatg gctacgtaga     3266

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     3326

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     3386

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag                        3428


<210>  21
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly 
1               5                   10                  15      


Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly 
            20                  25                  30          


Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser Ser Leu 
        35                  40                  45              


Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile Asp Lys 
    50                  55                  60                  


Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg 
65                  70                  75                  80  


Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His 
                85                  90                  95      


Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr Leu Leu 
            100                 105                 110         


Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile 
        115                 120                 125             


Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser 
    130                 135                 140                 


Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu 
145                 150                 155                 160 


Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala 
                165                 170                 175     


Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln Met Pro 
            180                 185                 190         


Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro 
        195                 200                 205             


Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys 
    210                 215                 220                 


Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu Gly Ala 
225                 230                 235                 240 


Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu 
                245                 250                 255     


Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser 
            260                 265                 270         


Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly 
        275                 280                 285             


Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe 
    290                 295                 300                 


Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu 
305                 310                 315                 320 


Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His 
                325                 330                 335     


Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn 
            340                 345                 350         


Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His Tyr Leu 
        355                 360                 365             


Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys 
    370                 375                 380                 


Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys 
385                 390                 395                 400 


Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln Glu Met 
                405                 410                 415     


Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His Leu Gln 
            420                 425                 430         


Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys 
        435                 440                 445 


<210>  22
<211>  2981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette


<220>
<221>  repeat_region
<222>  (1)..(168)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (211)..(310)
<223>  alpha mic/bik

<220>
<221>  enhancer
<222>  (317)..(416)
<223>  alpha mic/bik

<220>
<221>  misc_feature
<222>  (431)..(907)
<223>  TBG promoter

<220>
<221>  Intron
<222>  (939)..(1071)
<223>  SV40 misc intron (Promega)

<220>
<221>  CDS
<222>  (1092)..(2543)
<223>  hMSUD-E2co

<220>
<221>  polyA_signal
<222>  (2550)..(2764)
<223>  BGH polyA

<220>
<221>  misc_feature
<222>  (2806)..(2851)
<223>  Additional AAV sequences

<220>
<221>  repeat_region
<222>  (2814)..(2981)
<223>  3'ITR

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc aggttaattt ttaaaaagca gtcaaaagtc      240

caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat ctcaggagca      300

caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag tggcccttgg      360

cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa cattccagat      420

ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa      480

tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta      540

aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct      600

tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact      660

taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag      720

ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg      780

gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac      840

taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc      900

tgagagactg cagaagttgg tcgtgaggca ctgggcaggt aagtatcaag gttacaagac      960

aggtttaagg agaccaatag aaactgggct tgtcgagaca gagaagactc ttgcgtttct     1020

gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca ggtgtccagg     1080

cggccgccac c atg gcc gcc gtc aga atg ctg aga acc tgg tcc aga aac      1130
             Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn          
             1               5                   10                       

gcc ggc aag ctg atc tgc gtg cgg tac ttt cag acc tgc ggc aat gtg       1178
Ala Gly Lys Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val           
    15                  20                  25                            

cac gtg ctg aag ccc aac tac gtg tgc ttc ttc ggc tac ccc agc ttc       1226
His Val Leu Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe           
30                  35                  40                  45            

aag tac tct cac cct cac cac ttt ctc aag acc acc gcc gct ctg aga       1274
Lys Tyr Ser His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg           
                50                  55                  60                

gga cag gtg gtg cag ttc aag ctg agc gac atc ggc gag ggc atc aga       1322
Gly Gln Val Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg           
            65                  70                  75                    

gaa gtg acc gtg aaa gag tgg tac gtc aaa gag ggc gac acc gtc agc       1370
Glu Val Thr Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser           
        80                  85                  90                        

cag ttc gac agc atc tgt gaa gtg cag agc gac aag gcc agc gtg acc       1418
Gln Phe Asp Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr           
    95                  100                 105                           

atc acc agc aga tac gac ggc gtg atc aag aag ctg tac tac aac ctg       1466
Ile Thr Ser Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu           
110                 115                 120                 125           

gac gat atc gcc tac gtg ggc aag ccc ctg gtg gac att gaa aca gag       1514
Asp Asp Ile Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu           
                130                 135                 140               

gcc ctg aag gac agc gaa gag gac gtg gtg gaa acc cct gcc gtg tct       1562
Ala Leu Lys Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser           
            145                 150                 155                   

cac gac gag cac acc cac caa gag atc aag ggc aga aag acc ctg gcc       1610
His Asp Glu His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala           
        160                 165                 170                       

aca cca gct gtt aga cgg ctg gcc atg gaa aac aac atc aag ctg tcc       1658
Thr Pro Ala Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser           
    175                 180                 185                           

gag gtc gtc ggc agc ggc aag gat ggc aga atc ctg aaa gag gac atc       1706
Glu Val Val Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile           
190                 195                 200                 205           

ctg aac tac ctc gag aag cag acc ggc gcc atc ctg cct cca tct cca       1754
Leu Asn Tyr Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro           
                210                 215                 220               

aag gtg gaa atc atg cct cct cca cct aag cct aag gac atg acc gtg       1802
Lys Val Glu Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val           
            225                 230                 235                   

cct atc ctg gtg tcc aag cct cct gtg ttc acc ggc aag gac aag acc       1850
Pro Ile Leu Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr           
        240                 245                 250                       

gag cca atc aag ggc ttc cag aaa gcc atg gtc aag acc atg agc gct       1898
Glu Pro Ile Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala           
    255                 260                 265                           

gcc ctg aag atc cct cac ttt ggc tac tgc gac gag atc gac ctg acc       1946
Ala Leu Lys Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr           
270                 275                 280                 285           

gag ctg gtt aag ctg aga gag gaa ctg aag cct atc gcc ttc gcc aga       1994
Glu Leu Val Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg           
                290                 295                 300               

ggc atc aaa ctg agc ttc atg ccg ttc ttt ctg aag gcc gcc tct ctg       2042
Gly Ile Lys Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu           
            305                 310                 315                   

ggc ctg ctg cag ttc cct att ctg aac gcc agc gtg gac gag aac tgc       2090
Gly Leu Leu Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys           
        320                 325                 330                       

cag aac atc acc tac aag gcc tct cac aac atc gga atc gcc atg gac       2138
Gln Asn Ile Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp           
    335                 340                 345                           

aca gag cag ggc ctg atc gtg ccc aac gtg aag aac gtg cag att tgc       2186
Thr Glu Gln Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys           
350                 355                 360                 365           

tcc atc ttc gac att gcc acc gag ctg aac cgg ctg cag aaa ctg gga       2234
Ser Ile Phe Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly           
                370                 375                 380               

tct gtg ggc cag ctg agc acc acc gat ctt aca ggc ggc acc ttc aca       2282
Ser Val Gly Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr           
            385                 390                 395                   

ctg tcc aac atc ggc tct atc ggc ggc aca ttc gcc aag cct gtg atc       2330
Leu Ser Asn Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile           
        400                 405                 410                       

atg cca cca gag gtg gcc att gga gcc ctg ggc agc att aag gcc att       2378
Met Pro Pro Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile           
    415                 420                 425                           

cct cgg ttc aac cag aaa ggc gag gtg tac aag gcc cag atc atg aac       2426
Pro Arg Phe Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn           
430                 435                 440                 445           

gtg tct tgg agc gcc gac cac aga gtg atc gat ggc gcc acc atg agc       2474
Val Ser Trp Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser           
                450                 455                 460               

aga ttc agc aac ctg tgg aag tcc tac ctg gaa aac ccc gcc ttc atg       2522
Arg Phe Ser Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met           
            465                 470                 475                   

ctg ctg gac ctg aag tga taa agatctgcct cgactgtgcc ttctagttgc          2573
Leu Leu Asp Leu Lys                                                       
        480                                                               

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2633

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2693

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2753

catgctgggg actcgagtta agggcgaatt cccgataagg atcttcctag agcatggcta     2813

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     2873

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     2933

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcag                  2981


<210>  23
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys 
1               5                   10                  15      


Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu 
            20                  25                  30          


Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser 
        35                  40                  45              


His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val 
    50                  55                  60                  


Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr 
65                  70                  75                  80  


Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp 
                85                  90                  95      


Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser 
            100                 105                 110         


Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile 
        115                 120                 125             


Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys 
    130                 135                 140                 


Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu 
145                 150                 155                 160 


His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala 
                165                 170                 175     


Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val 
            180                 185                 190         


Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr 
        195                 200                 205             


Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu 
    210                 215                 220                 


Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu 
225                 230                 235                 240 


Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile 
                245                 250                 255     


Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys 
            260                 265                 270         


Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val 
        275                 280                 285             


Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys 
    290                 295                 300                 


Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu 
305                 310                 315                 320 


Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile 
                325                 330                 335     


Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln 
            340                 345                 350         


Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe 
        355                 360                 365             


Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly 
    370                 375                 380                 


Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn 
385                 390                 395                 400 


Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro 
                405                 410                 415     


Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe 
            420                 425                 430         


Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp 
        435                 440                 445             


Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser 
    450                 455                 460                 


Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp 
465                 470                 475                 480 


Leu Lys 
        


<210>  24
<211>  3538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette


<220>
<221>  repeat_region
<222>  (1)..(168)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (211)..(310)
<223>  alpha mic/bik

<220>
<221>  enhancer
<222>  (317)..(416)
<223>  alpha mic/bik

<220>
<221>  misc_feature
<222>  (431)..(907)
<223>  TBG promoter

<220>
<221>  Intron
<222>  (939)..(1071)
<223>  SV40 misc intron (Promega)

<220>
<221>  misc_feature
<222>  (1086)..(1091)
<223>  Kozak

<220>
<221>  CDS
<222>  (1092)..(2543)
<223>  hMSUD-E2co

<220>
<221>  misc_feature
<222>  (2559)..(3100)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (3107)..(3321)
<223>  BGH polyA

<220>
<221>  misc_feature
<222>  (3363)..(3408)
<223>  additional AAV sequences

<220>
<221>  repeat_region
<222>  (3371)..(3538)
<223>  3'ITR

<400>  24
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc aggttaattt ttaaaaagca gtcaaaagtc      240

caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat ctcaggagca      300

caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag tggcccttgg      360

cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa cattccagat      420

ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa      480

tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta      540

aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct      600

tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact      660

taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag      720

ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg      780

gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac      840

taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc      900

tgagagactg cagaagttgg tcgtgaggca ctgggcaggt aagtatcaag gttacaagac      960

aggtttaagg agaccaatag aaactgggct tgtcgagaca gagaagactc ttgcgtttct     1020

gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca ggtgtccagg     1080

cggccgccac c atg gcc gcc gtc aga atg ctg aga acc tgg tcc aga aac      1130
             Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn          
             1               5                   10                       

gcc ggc aag ctg atc tgc gtg cgg tac ttt cag acc tgc ggc aat gtg       1178
Ala Gly Lys Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val           
    15                  20                  25                            

cac gtg ctg aag ccc aac tac gtg tgc ttc ttc ggc tac ccc agc ttc       1226
His Val Leu Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe           
30                  35                  40                  45            

aag tac tct cac cct cac cac ttt ctc aag acc acc gcc gct ctg aga       1274
Lys Tyr Ser His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg           
                50                  55                  60                

gga cag gtg gtg cag ttc aag ctg agc gac atc ggc gag ggc atc aga       1322
Gly Gln Val Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg           
            65                  70                  75                    

gaa gtg acc gtg aaa gag tgg tac gtc aaa gag ggc gac acc gtc agc       1370
Glu Val Thr Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser           
        80                  85                  90                        

cag ttc gac agc atc tgt gaa gtg cag agc gac aag gcc agc gtg acc       1418
Gln Phe Asp Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr           
    95                  100                 105                           

atc acc agc aga tac gac ggc gtg atc aag aag ctg tac tac aac ctg       1466
Ile Thr Ser Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu           
110                 115                 120                 125           

gac gat atc gcc tac gtg ggc aag ccc ctg gtg gac att gaa aca gag       1514
Asp Asp Ile Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu           
                130                 135                 140               

gcc ctg aag gac agc gaa gag gac gtg gtg gaa acc cct gcc gtg tct       1562
Ala Leu Lys Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser           
            145                 150                 155                   

cac gac gag cac acc cac caa gag atc aag ggc aga aag acc ctg gcc       1610
His Asp Glu His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala           
        160                 165                 170                       

aca cca gct gtt aga cgg ctg gcc atg gaa aac aac atc aag ctg tcc       1658
Thr Pro Ala Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser           
    175                 180                 185                           

gag gtc gtc ggc agc ggc aag gat ggc aga atc ctg aaa gag gac atc       1706
Glu Val Val Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile           
190                 195                 200                 205           

ctg aac tac ctc gag aag cag acc ggc gcc atc ctg cct cca tct cca       1754
Leu Asn Tyr Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro           
                210                 215                 220               

aag gtg gaa atc atg cct cct cca cct aag cct aag gac atg acc gtg       1802
Lys Val Glu Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val           
            225                 230                 235                   

cct atc ctg gtg tcc aag cct cct gtg ttc acc ggc aag gac aag acc       1850
Pro Ile Leu Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr           
        240                 245                 250                       

gag cca atc aag ggc ttc cag aaa gcc atg gtc aag acc atg agc gct       1898
Glu Pro Ile Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala           
    255                 260                 265                           

gcc ctg aag atc cct cac ttt ggc tac tgc gac gag atc gac ctg acc       1946
Ala Leu Lys Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr           
270                 275                 280                 285           

gag ctg gtt aag ctg aga gag gaa ctg aag cct atc gcc ttc gcc aga       1994
Glu Leu Val Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg           
                290                 295                 300               

ggc atc aaa ctg agc ttc atg ccg ttc ttt ctg aag gcc gcc tct ctg       2042
Gly Ile Lys Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu           
            305                 310                 315                   

ggc ctg ctg cag ttc cct att ctg aac gcc agc gtg gac gag aac tgc       2090
Gly Leu Leu Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys           
        320                 325                 330                       

cag aac atc acc tac aag gcc tct cac aac atc gga atc gcc atg gac       2138
Gln Asn Ile Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp           
    335                 340                 345                           

aca gag cag ggc ctg atc gtg ccc aac gtg aag aac gtg cag att tgc       2186
Thr Glu Gln Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys           
350                 355                 360                 365           

tcc atc ttc gac att gcc acc gag ctg aac cgg ctg cag aaa ctg gga       2234
Ser Ile Phe Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly           
                370                 375                 380               

tct gtg ggc cag ctg agc acc acc gat ctt aca ggc ggc acc ttc aca       2282
Ser Val Gly Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr           
            385                 390                 395                   

ctg tcc aac atc ggc tct atc ggc ggc aca ttc gcc aag cct gtg atc       2330
Leu Ser Asn Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile           
        400                 405                 410                       

atg cca cca gag gtg gcc att gga gcc ctg ggc agc att aag gcc att       2378
Met Pro Pro Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile           
    415                 420                 425                           

cct cgg ttc aac cag aaa ggc gag gtg tac aag gcc cag atc atg aac       2426
Pro Arg Phe Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn           
430                 435                 440                 445           

gtg tct tgg agc gcc gac cac aga gtg atc gat ggc gcc acc atg agc       2474
Val Ser Trp Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser           
                450                 455                 460               

aga ttc agc aac ctg tgg aag tcc tac ctg gaa aac ccc gcc ttc atg       2522
Arg Phe Ser Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met           
            465                 470                 475                   

ctg ctg gac ctg aag tga taa agatctgccg gatccaatca acctctggat          2573
Leu Leu Asp Leu Lys                                                       
        480                                                               

tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt     2633

ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc     2693

tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg     2753

caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc     2813

accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa     2873

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat     2933

tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc     2993

tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt     3053

ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgaga tctgcctcga     3113

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     3173

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     3233

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3293

gggaagacaa tagcaggcat gctggggact cgagttaagg gcgaattccc gataaggatc     3353

ttcctagagc atggctacgt agataagtag catggcgggt taatcattaa ctacaaggaa     3413

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     3473

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     3533

cgcag                                                                 3538


<210>  25
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys 
1               5                   10                  15      


Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu 
            20                  25                  30          


Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser 
        35                  40                  45              


His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val 
    50                  55                  60                  


Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr 
65                  70                  75                  80  


Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp 
                85                  90                  95      


Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser 
            100                 105                 110         


Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile 
        115                 120                 125             


Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys 
    130                 135                 140                 


Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu 
145                 150                 155                 160 


His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala 
                165                 170                 175     


Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val 
            180                 185                 190         


Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr 
        195                 200                 205             


Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu 
    210                 215                 220                 


Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu 
225                 230                 235                 240 


Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile 
                245                 250                 255     


Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys 
            260                 265                 270         


Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val 
        275                 280                 285             


Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys 
    290                 295                 300                 


Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu 
305                 310                 315                 320 


Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile 
                325                 330                 335     


Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln 
            340                 345                 350         


Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe 
        355                 360                 365             


Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly 
    370                 375                 380                 


Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn 
385                 390                 395                 400 


Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro 
                405                 410                 415     


Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe 
            420                 425                 430         


Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp 
        435                 440                 445             


Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser 
    450                 455                 460                 


Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp 
465                 470                 475                 480 


Leu Lys 
        


<210>  26
<211>  3811
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette


<220>
<221>  repeat_region
<222>  (1)..(108)
<223>  Repeat Region 1 5'ITR

<220>
<221>  repeat_region
<222>  (182)..(563)
<223>  Repeat region 1 - CMV IE promoter

<220>
<221>  promoter
<222>  (566)..(847)
<223>  Promoter E1 CB promoter

<220>
<221>  TATA_signal
<222>  (820)..(823)
<223>  TATA signal 1

<220>
<221>  Intron
<222>  (940)..(1911)
<223>  chicken beta actin intron

<220>
<221>  CDS
<222>  (1924)..(3372)
<223>  hMSUD-E2co

<220>
<221>  polyA_signal
<222>  (3386)..(3617)
<223>  PolyA  SV40

<220>
<221>  repeat_region
<222>  (3682)..(3811)
<223>  Repeat Region - 3'ITR

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttccttg tagttaatga      120

ttaacccgcc atgctactta tctacgtagc catgctctag gaagatcctc tagaactata      180

gctagtcgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt      240

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      300

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      360

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      420

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      480

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      540

tacgtattag tcatcgctat taccatggtc gaggtgagcc ccacgttctg cttcactctc      600

cccatctccc ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt      660

gcagcgatgg gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag      720

gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga      780

aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg      840

cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc      900

cgcccgcccc ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct      960

tctcctccgg gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg     1020

cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt     1080

gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt     1140

gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg     1200

gccgggggcg gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg     1260

ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc     1320

ctgcaccccc ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg     1380

gggcgtggcg cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc     1440

ggggcggggc cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc     1500

gccggcggct gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag     1560

agggcgcagg gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc     1620

cgcaccccct ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc     1680

ggggagggcc ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc     1740

tgtccgcggg gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg     1800

cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta     1860

cagctcctgg gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattcgcc     1920

acc atg gcc gcc gtc aga atg ctg aga acc tgg tcc aga aac gcc ggc       1968
    Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly           
    1               5                   10                  15            

aag ctg atc tgc gtg cgg tac ttt cag acc tgc ggc aat gtg cac gtg       2016
Lys Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val           
                20                  25                  30                

ctg aag ccc aac tac gtg tgc ttc ttc ggc tac ccc agc ttc aag tac       2064
Leu Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr           
            35                  40                  45                    

tct cac cct cac cac ttt ctc aag acc acc gcc gct ctg aga gga cag       2112
Ser His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln           
        50                  55                  60                        

gtg gtg cag ttc aag ctg agc gac atc ggc gag ggc atc aga gaa gtg       2160
Val Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val           
    65                  70                  75                            

acc gtg aaa gag tgg tac gtc aaa gag ggc gac acc gtc agc cag ttc       2208
Thr Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe           
80                  85                  90                  95            

gac agc atc tgt gaa gtg cag agc gac aag gcc agc gtg acc atc acc       2256
Asp Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr           
                100                 105                 110               

agc aga tac gac ggc gtg atc aag aag ctg tac tac aac ctg gac gat       2304
Ser Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp           
            115                 120                 125                   

atc gcc tac gtg ggc aag ccc ctg gtg gac att gaa aca gag gcc ctg       2352
Ile Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu           
        130                 135                 140                       

aag gac agc gaa gag gac gtg gtg gaa acc cct gcc gtg tct cac gac       2400
Lys Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp           
    145                 150                 155                           

gag cac acc cac caa gag atc aag ggc aga aag acc ctg gcc aca cca       2448
Glu His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro           
160                 165                 170                 175           

gct gtt aga cgg ctg gcc atg gaa aac aac atc aag ctg tcc gag gtc       2496
Ala Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val           
                180                 185                 190               

gtc ggc agc ggc aag gat ggc aga atc ctg aaa gag gac atc ctg aac       2544
Val Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn           
            195                 200                 205                   

tac ctc gag aag cag acc ggc gcc atc ctg cct cca tct cca aag gtg       2592
Tyr Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val           
        210                 215                 220                       

gaa atc atg cct cct cca cct aag cct aag gac atg acc gtg cct atc       2640
Glu Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile           
    225                 230                 235                           

ctg gtg tcc aag cct cct gtg ttc acc ggc aag gac aag acc gag cca       2688
Leu Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro           
240                 245                 250                 255           

atc aag ggc ttc cag aaa gcc atg gtc aag acc atg agc gct gcc ctg       2736
Ile Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu           
                260                 265                 270               

aag atc cct cac ttt ggc tac tgc gac gag atc gac ctg acc gag ctg       2784
Lys Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu           
            275                 280                 285                   

gtt aag ctg aga gag gaa ctg aag cct atc gcc ttc gcc aga ggc atc       2832
Val Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile           
        290                 295                 300                       

aaa ctg agc ttc atg ccg ttc ttt ctg aag gcc gcc tct ctg ggc ctg       2880
Lys Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu           
    305                 310                 315                           

ctg cag ttc cct att ctg aac gcc agc gtg gac gag aac tgc cag aac       2928
Leu Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn           
320                 325                 330                 335           

atc acc tac aag gcc tct cac aac atc gga atc gcc atg gac aca gag       2976
Ile Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu           
                340                 345                 350               

cag ggc ctg atc gtg ccc aac gtg aag aac gtg cag att tgc tcc atc       3024
Gln Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile           
            355                 360                 365                   

ttc gac att gcc acc gag ctg aac cgg ctg cag aaa ctg gga tct gtg       3072
Phe Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val           
        370                 375                 380                       

ggc cag ctg agc acc acc gat ctt aca ggc ggc acc ttc aca ctg tcc       3120
Gly Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser           
    385                 390                 395                           

aac atc ggc tct atc ggc ggc aca ttc gcc aag cct gtg atc atg cca       3168
Asn Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro           
400                 405                 410                 415           

cca gag gtg gcc att gga gcc ctg ggc agc att aag gcc att cct cgg       3216
Pro Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg           
                420                 425                 430               

ttc aac cag aaa ggc gag gtg tac aag gcc cag atc atg aac gtg tct       3264
Phe Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser           
            435                 440                 445                   

tgg agc gcc gac cac aga gtg atc gat ggc gcc acc atg agc aga ttc       3312
Trp Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe           
        450                 455                 460                       

agc aac ctg tgg aag tcc tac ctg gaa aac ccc gcc ttc atg ctg ctg       3360
Ser Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu           
    465                 470                 475                           

gac ctg aag tga taagcggccg cttcgagcag acatgataag atacattgat           3412
Asp Leu Lys                                                               
480                                                                       

gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt     3472

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat     3532

tgcattcatt ttatgtttca ggttcagggg gagatgtggg aggtttttta aagcaagtaa     3592

aacctctaca aatgtggtaa aatcgataag gatcttccta gagcatggct acgtagataa     3652

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     3712

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     3772

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                            3811


<210>  27
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys 
1               5                   10                  15      


Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu 
            20                  25                  30          


Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser 
        35                  40                  45              


His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val 
    50                  55                  60                  


Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr 
65                  70                  75                  80  


Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp 
                85                  90                  95      


Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser 
            100                 105                 110         


Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile 
        115                 120                 125             


Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys 
    130                 135                 140                 


Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu 
145                 150                 155                 160 


His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala 
                165                 170                 175     


Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val 
            180                 185                 190         


Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr 
        195                 200                 205             


Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu 
    210                 215                 220                 


Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu 
225                 230                 235                 240 


Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile 
                245                 250                 255     


Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys 
            260                 265                 270         


Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val 
        275                 280                 285             


Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys 
    290                 295                 300                 


Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu 
305                 310                 315                 320 


Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile 
                325                 330                 335     


Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln 
            340                 345                 350         


Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe 
        355                 360                 365             


Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly 
    370                 375                 380                 


Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn 
385                 390                 395                 400 


Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro 
                405                 410                 415     


Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe 
            420                 425                 430         


Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp 
        435                 440                 445             


Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser 
    450                 455                 460                 


Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp 
465                 470                 475                 480 


Leu Lys 
        


<210>  28
<211>  3027
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette


<220>
<221>  repeat_region
<222>  (1)..(108)
<223>  Repeat region - 5'ITR

<220>
<221>  enhancer
<222>  (175)..(385)
<223>  2R5 S

<220>
<221>  enhancer
<222>  (386)..(596)
<223>  2R5 S

<220>
<221>  enhancer
<222>  (596)..(806)
<223>  2R5 S

<220>
<221>  promoter
<222>  (807)..(952)
<223>  shortened MCK promoter

<220>
<221>  Intron
<222>  (979)..(1111)
<223>  PI (promega intron)

<220>
<221>  CDS
<222>  (1140)..(2591)
<223>  hMSUD-E2co

<220>
<221>  polyA_signal
<222>  (2602)..(2833)
<223>  polyA SV40

<220>
<221>  repeat_region
<222>  (2898)..(3027)
<223>  3'ITR

<400>  28
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttccttg tagttaatga      120

ttaacccgcc atgctactta tctacgtagc catgctctag gaagatcctc tagccactac      180

gggtctaggc tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata      240

attaacccca acacctgctg cccccccccc cccaacacct gctgcctgag cctgagcggt      300

taccccaccc cggtgcctgg gtcttaggct ctgtacacca tggaggagaa gctcgctcta      360

aaaataaccc tgtccctggt gggcccacta cgggtctagg ctgcccatgt aaggaggcaa      420

ggcctgggga cacccgagat gcctggttat aattaacccc aacacctgct gccccccccc      480

ccccaacacc tgctgcctga gcctgagcgg ttaccccacc ccggtgcctg ggtcttaggc      540

tctgtacacc atggaggaga agctcgctct aaaaataacc ctgtccctgg tgggccacta      600

cgggtctagg ctgcccatgt aaggaggcaa ggcctgggga cacccgagat gcctggttat      660

aattaacccc aacacctgct gccccccccc ccccaacacc tgctgcctga gcctgagcgg      720

ttaccccacc ccggtgcctg ggtcttaggc tctgtacacc atggaggaga agctcgctct      780

aaaaataacc ctgtccctgg tgggcccctc cctggggaca gcccctcctg gctagtcaca      840

ccctgtaggc tcctctatat aacccagggg cacaggggct gcccccgggt cacggggatc      900

ctctagacct ccgaacggta agagcctagc atgtagaact ggttaccctg cagaagttgg      960

tcgtgaggca ctgggcaggt aagtatcaag gttacaagac aggtttaagg agaccaatag     1020

aaactgggct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     1080

actgacatcc actttgcctt tctctccaca ggtgtccagg cggccgcgaa ttcgccacc      1139

atg gcc gcc gtc aga atg ctg aga acc tgg tcc aga aac gcc ggc aag       1187
Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys           
1               5                   10                  15                

ctg atc tgc gtg cgg tac ttt cag acc tgc ggc aat gtg cac gtg ctg       1235
Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu           
            20                  25                  30                    

aag ccc aac tac gtg tgc ttc ttc ggc tac ccc agc ttc aag tac tct       1283
Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser           
        35                  40                  45                        

cac cct cac cac ttt ctc aag acc acc gcc gct ctg aga gga cag gtg       1331
His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val           
    50                  55                  60                            

gtg cag ttc aag ctg agc gac atc ggc gag ggc atc aga gaa gtg acc       1379
Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr           
65                  70                  75                  80            

gtg aaa gag tgg tac gtc aaa gag ggc gac acc gtc agc cag ttc gac       1427
Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp           
                85                  90                  95                

agc atc tgt gaa gtg cag agc gac aag gcc agc gtg acc atc acc agc       1475
Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser           
            100                 105                 110                   

aga tac gac ggc gtg atc aag aag ctg tac tac aac ctg gac gat atc       1523
Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile           
        115                 120                 125                       

gcc tac gtg ggc aag ccc ctg gtg gac att gaa aca gag gcc ctg aag       1571
Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys           
    130                 135                 140                           

gac agc gaa gag gac gtg gtg gaa acc cct gcc gtg tct cac gac gag       1619
Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu           
145                 150                 155                 160           

cac acc cac caa gag atc aag ggc aga aag acc ctg gcc aca cca gct       1667
His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala           
                165                 170                 175               

gtt aga cgg ctg gcc atg gaa aac aac atc aag ctg tcc gag gtc gtc       1715
Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val           
            180                 185                 190                   

ggc agc ggc aag gat ggc aga atc ctg aaa gag gac atc ctg aac tac       1763
Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr           
        195                 200                 205                       

ctc gag aag cag acc ggc gcc atc ctg cct cca tct cca aag gtg gaa       1811
Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu           
    210                 215                 220                           

atc atg cct cct cca cct aag cct aag gac atg acc gtg cct atc ctg       1859
Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu           
225                 230                 235                 240           

gtg tcc aag cct cct gtg ttc acc ggc aag gac aag acc gag cca atc       1907
Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile           
                245                 250                 255               

aag ggc ttc cag aaa gcc atg gtc aag acc atg agc gct gcc ctg aag       1955
Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys           
            260                 265                 270                   

atc cct cac ttt ggc tac tgc gac gag atc gac ctg acc gag ctg gtt       2003
Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val           
        275                 280                 285                       

aag ctg aga gag gaa ctg aag cct atc gcc ttc gcc aga ggc atc aaa       2051
Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys           
    290                 295                 300                           

ctg agc ttc atg ccg ttc ttt ctg aag gcc gcc tct ctg ggc ctg ctg       2099
Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu           
305                 310                 315                 320           

cag ttc cct att ctg aac gcc agc gtg gac gag aac tgc cag aac atc       2147
Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile           
                325                 330                 335               

acc tac aag gcc tct cac aac atc gga atc gcc atg gac aca gag cag       2195
Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln           
            340                 345                 350                   

ggc ctg atc gtg ccc aac gtg aag aac gtg cag att tgc tcc atc ttc       2243
Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe           
        355                 360                 365                       

gac att gcc acc gag ctg aac cgg ctg cag aaa ctg gga tct gtg ggc       2291
Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly           
    370                 375                 380                           

cag ctg agc acc acc gat ctt aca ggc ggc acc ttc aca ctg tcc aac       2339
Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn           
385                 390                 395                 400           

atc ggc tct atc ggc ggc aca ttc gcc aag cct gtg atc atg cca cca       2387
Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro           
                405                 410                 415               

gag gtg gcc att gga gcc ctg ggc agc att aag gcc att cct cgg ttc       2435
Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe           
            420                 425                 430                   

aac cag aaa ggc gag gtg tac aag gcc cag atc atg aac gtg tct tgg       2483
Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp           
        435                 440                 445                       

agc gcc gac cac aga gtg atc gat ggc gcc acc atg agc aga ttc agc       2531
Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser           
    450                 455                 460                           

aac ctg tgg aag tcc tac ctg gaa aac ccc gcc ttc atg ctg ctg gac       2579
Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp           
465                 470                 475                 480           

ctg aag tga taa gcggccgctt cgagcagaca tgataagata cattgatgag           2631
Leu Lys                                                                   
                                                                          

tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat     2691

gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc     2751

attcatttta tgtttcaggt tcagggggag atgtgggagg ttttttaaag caagtaaaac     2811

ctctacaaat gtggtaaaat cgataaggat cttcctagag catggctacg tagataagta     2871

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     2931

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     2991

tgcccgggcg gcctcagtga gcgagcgagc gcgcag                               3027


<210>  29
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys 
1               5                   10                  15      


Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu 
            20                  25                  30          


Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser 
        35                  40                  45              


His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val 
    50                  55                  60                  


Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr 
65                  70                  75                  80  


Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp 
                85                  90                  95      


Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser 
            100                 105                 110         


Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile 
        115                 120                 125             


Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys 
    130                 135                 140                 


Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu 
145                 150                 155                 160 


His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala 
                165                 170                 175     


Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val 
            180                 185                 190         


Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr 
        195                 200                 205             


Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu 
    210                 215                 220                 


Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu 
225                 230                 235                 240 


Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile 
                245                 250                 255     


Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys 
            260                 265                 270         


Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val 
        275                 280                 285             


Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys 
    290                 295                 300                 


Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu 
305                 310                 315                 320 


Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile 
                325                 330                 335     


Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln 
            340                 345                 350         


Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe 
        355                 360                 365             


Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly 
    370                 375                 380                 


Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn 
385                 390                 395                 400 


Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro 
                405                 410                 415     


Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe 
            420                 425                 430         


Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp 
        435                 440                 445             


Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser 
    450                 455                 460                 


Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp 
465                 470                 475                 480 


Leu Lys 
        


<210>  30
<211>  1449
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA-E2

<400>  30
auggccgccg ucagaaugcu gagaaccugg uccagaaacg ccggcaagcu gaucugcgug       60

cgguacuuuc agaccugcgg caaugugcac gugcugaagc ccaacuacgu gugcuucuuc      120

ggcuacccca gcuucaagua cucucacccu caccacuuuc ucaagaccac cgccgcucug      180

agaggacagg uggugcaguu caagcugagc gacaucggcg agggcaucag agaagugacc      240

gugaaagagu gguacgucaa agagggcgac accgucagcc aguucgacag caucugugaa      300

gugcagagcg acaaggccag cgugaccauc accagcagau acgacggcgu gaucaagaag      360

cuguacuaca accuggacga uaucgccuac gugggcaagc cccuggugga cauugaaaca      420

gaggcccuga aggacagcga agaggacgug guggaaaccc cugccguguc ucacgacgag      480

cacacccacc aagagaucaa gggcagaaag acccuggcca caccagcugu uagacggcug      540

gccauggaaa acaacaucaa gcuguccgag gucgucggca gcggcaagga uggcagaauc      600

cugaaagagg acauccugaa cuaccucgag aagcagaccg gcgccauccu gccuccaucu      660

ccaaaggugg aaaucaugcc uccuccaccu aagccuaagg acaugaccgu gccuauccug      720

guguccaagc cuccuguguu caccggcaag gacaagaccg agccaaucaa gggcuuccag      780

aaagccaugg ucaagaccau gagcgcugcc cugaagaucc cucacuuugg cuacugcgac      840

gagaucgacc ugaccgagcu gguuaagcug agagaggaac ugaagccuau cgccuucgcc      900

agaggcauca aacugagcuu caugccguuc uuucugaagg ccgccucucu gggccugcug      960

caguucccua uucugaacgc cagcguggac gagaacugcc agaacaucac cuacaaggcc     1020

ucucacaaca ucggaaucgc cauggacaca gagcagggcc ugaucgugcc caacgugaag     1080

aacgugcaga uuugcuccau cuucgacauu gccaccgagc ugaaccggcu gcagaaacug     1140

ggaucugugg gccagcugag caccaccgau cuuacaggcg gcaccuucac acuguccaac     1200

aucggcucua ucggcggcac auucgccaag ccugugauca ugccaccaga gguggccauu     1260

ggagcccugg gcagcauuaa ggccauuccu cgguucaacc agaaaggcga gguguacaag     1320

gcccagauca ugaacguguc uuggagcgcc gaccacagag ugaucgaugg cgccaccaug     1380

agcagauuca gcaaccugug gaaguccuac cuggaaaacc ccgccuucau gcugcuggac     1440

cugaaguga                                                             1449


<210>  31
<211>  1339
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA-E1a

<400>  31
auggcugugg cuauugcugc ugccagagug uggcggcuga auagaggacu gucucaggcu       60

gcucugcugc ugcugagaca accuggugca agaggacugg ccagaagcca uccuccuaga      120

cagcagcaac aguucagcag ccuggacgac aagccucagu uuccuggcgc cuccgccgag      180

uucaucgaca agcuggaauu cauccagccu aacgugauca gcggcauccc caucuacaga      240

gugauggaca gacagggcca gaucaucaac cccagcgagg acccucaccu gcccaaagaa      300

aaggugcuga agcuguacaa gagcaugacc cugcugaaca caauggaccg gauccuguac      360

gagagccaga gacagggcag aaucagcuuc uacaugacca acuacggcga agagggcaca      420

cacgugggau cugcugccgc ucuggacaac accgaccugg uguuuggcca guacagagaa      480

gccggcgugc ugauguaccg ggacuacccu cuggaacugu ucauggccca gugcuacggc      540

aacaucagcg accucggaaa gggcagacag augccugugc acuacggcug caaagaacgg      600

cacuucguga ccaucagcag cccucuggcc acacagauuc cucaggcugu gggagccgcc      660

uacgccgcca aaagagccaa cgccaacaga guggucaucu gcuacuuugg cgagggcgcu      720

gcuucugaag gcgacgcuca cgccggcuuc aauuucgccg ccacucugga gugccccauc      780

aucuuuuucu gccggaacaa cggcuacgcc aucagcacac cuaccagcga gcaguauaga      840

ggcgacggaa uugccgccag aggaccuggc uauggcauca ugagcaucag aguggacggc      900

aacgacgugu ucgccgugua caacgccacc aaagaagcca ggcggagagc cguggcugag      960

aaccagccuu uucugaucga ggccaugacc uaccggaucg gccaccacag caccuccgac     1020

gauagcagcg ccuacagauc cguggacgaa gugaacuacu gggacaagca ggaucacccc     1080

aucuccagac ugcggcacua ccugcugucu caaggcuggu gggacgaaga acaagagaag     1140

gccuggcgga agcagagccg gcggaaagug auggaagccu uugagcaggc cgagcggaag     1200

cccaagccua auccuaaccu gcuguucagc gacguguacc aagagaugcc ugcucagcug     1260

cgcaagcagc aagaaagccu ggccagacac cugcagaccu acggcgagca cuacccacug     1320

gaccacuucg acaaaugau                                                  1339


<210>  32
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA-E1b

<400>  32
auggcuguug uugcugcugc agcuggaugg cugcugagac uuagagcugc uggcgccgaa       60

ggccauugga gaagguugcc uggugcugga cuggccagag gcuuucugca uccugccgcc      120

acaguggaag acgccgcuca gagaaggcag gucgcccacu ucaccuucca gccugauccu      180

gagccuagag aguacggcca gacacagaag augaaccugu uccagagcgu gacaagcgcc      240

cuggacaaca gccuggccaa agauccuacc gccgugaucu ucggagagga cguggcauuc      300

ggcggcgugu ucagauguac agugggccug agagauaagu acggcaagga ccggguguuc      360

aacacacccc ugugugaaca gggcaucguc ggcuucggaa ucggaauugc ugugacaggc      420

gccaccgcca uugccgagau ucaguucgcc gacuacaucu uccccgccuu cgaccagauc      480

gugaacgagg ccgccaagua cagauacaga agcggcgacc uguucaacug cggcagccug      540

accauuagaa gcccuugggg cuguguugga cacggcgccc uguaucacuc ucagagcccu      600

gaggccuucu ucgcccacug uccuggcauc aaggugguca ucccuagaag ccccuuucag      660

gccaagggcc ugcugcuguc cugcaucgag gacaagaacc ccugcaucuu cuucgagccc      720

aagauccugu accgggcugc cgcugaggaa gugccuaucg agcccuacaa caucccucug      780

agccaggccg aagugaucca agagggcucc gaugugacac ugguggccug gggaacacag      840

gugcacguga ucagagaagu ggccagcaug gcuaaagaga agcugggcgu cagcugugaa      900

gugaucgacc ugagaacaau cauccccugg gacgucgaca ccaucugcaa guccgugauc      960

aagaccggca gacugcugau cucucacgag gcuccucuga caggcggcuu ugccucugag     1020

aucagcucca ccgugcaaga ggagugcuuc cugaaccugg aagccccaau cagcagagug     1080

ugcggcuacg acaccccuuu uccacacauc uuugagcccu ucuacauccc cgacaagugg     1140

aagugcuacg acgcccugcg gaagaugauc aacuacugau aa                        1182


