                               SEQUENCE LISTING

<110> FLAGSHIP PIONEERING INNOVATIONS VI, LLC
 
<120> METHODS OF DOSING CIRCULAR POLYRIBONUCLEOTIDES

<130> 55503-710.601

<140> PCT/US2020/038835
<141> 2020-06-19

<150> 62/863,725
<151> 2019-06-19

<160> 54    

<170> PatentIn version 3.5

<210> 1
<211> 3
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1
aug                                                                      3


<210> 2
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210> 3
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
gctactaact tcagcctgct gaagcaggct ggcgacgtgg aggagaaccc tggacct          57


<210> 4
<211> 221
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
gtaaaaagag gtgaaaccta ttatgtgtga gcagggcaca gacgttgaaa ctggagccag       60

gagaagtatt ggcaggcttt aggttattag gtggttactc tgtcttaaaa atgttctggc      120

tttcttcctg catccactgg catactcatg gtctgttttt aaatatttta attcccattt      180

acaaagtgat ttacccacaa gcccaacctg tctgtcttca g                          221


<210> 5
<211> 552
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt       60

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga      120

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg      180

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt      240

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat      300

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg      360

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg      420

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt      480

cgaggttaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac      540

acgatgataa ta                                                          552


<210> 6
<211> 6926
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattccat      960

tgagaaatga ctgagttccg gtgctctcaa gtcattgatc tttgtcgact tttatttggt     1020

ctctgtaata acgacttcaa aaacattaaa ttctgttgcg aagccagtaa gctacaaaaa     1080

gaaaaaacaa gagagaatgc tatagtcgta tagtatagtt tcccgactat ctgataccca     1140

ttacttatct agggggaatg cgaacccaaa attttatcag ttttctcgga tatcgataga     1200

tattggggaa taaatttaaa taaataaatt ttgggcgggt ttagggcgtg gcaaaaagtt     1260

ttttggcaaa tcgctagaaa tttacaagac ttataaaatt atgaaaaaat acaacaaaat     1320

tttaaacacg tgggcgtgac agttttgggc ggttttaggg cgttagagta ggcgaggaca     1380

gggttacatc gactaggctt tgatcctgat caagaatata tatactttat accgcttcct     1440

tctacatgtt acctattttt caacgaatct agtatacctt tttactgtac gatttatggg     1500

tataataata agctaaatcg agactaagtt ttattgttat atatattttt tttattttat     1560

gcagaaatta attaaaccgg tcctgcaggt gatcaggcgc gccggttacc ggccggcccc     1620

gcggagcgta agtattcaaa attccaaaat tttttactag aaatattcga ttttttaata     1680

ggcagtttct atactattgt atactattgt agattcgttg aaaagtatgt aacaggaaga     1740

ataaagcatt tccgaccatg taaagtatat atattcttaa taaggatcaa tagccgagtc     1800

gatctcgcca tgtccgtctg tcttattgtt ttattaccgc cgagacatca ggaactataa     1860

aagctagaag gatgagtttt agcatacaga ttctagagac aaggacgcag agcaagtttg     1920

ttgatccatg ctgccacgct ttaactttct caaattgccc aaaactgcca tgcccacatt     1980

tttgaactat tttcgaaatt ttttcataat tgtattactc gtgtaaattt ccatcaattt     2040

gccaaaaaac tttttgtcac gcgttaacgc cctaaagccg ccaatttggt cacgcccaca     2100

ctattgagca attatcaaat tttttctcat tttattcccc aatatctatc gatatccccg     2160

attatgaaat tattaaattt cgcgttcgca ttcacactag ctgagtaacg agtatctgat     2220

agttggggaa atcgacttat tttttatata caatgaaaat gaatttaatc atatgaatat     2280

cgattatagc tttttattta atatgaatat ttatttgggc ttaaggtgta acctcctcga     2340

cataagactc acatggcgca ggcacattga agacaaaaat actcattgtc gggtctcgca     2400

ccctccagca gcacctaaaa ttatgtcttc aattattgcc aacattggag acacaattag     2460

tctgtggcac ctcaggcggc cgctcgagtc tagagggccc gtttaaaccc gctgatcagc     2520

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     2580

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     2640

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     2700

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc     2760

ggaaagaacc agctggggct ctagggggta tccccacgcg ccctgtagcg gcgcattaag     2820

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     2880

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     2940

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     3000

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     3060

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     3120

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     3180

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct gtggaatgtg     3240

tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     3300

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     3360

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     3420

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     3480

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     3540

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     3600

tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     3660

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     3720

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     3780

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     3840

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     3900

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     3960

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     4020

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     4080

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     4140

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     4200

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     4260

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     4320

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     4380

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg     4440

ggttcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg     4500

ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc     4560

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     4620

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     4680

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt     4740

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     4800

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     4860

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     4920

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     4980

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     5040

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     5100

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     5160

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     5220

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     5280

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     5340

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt     5400

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     5460

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     5520

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     5580

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc     5640

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     5700

ctggtagcgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5760

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5820

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5880

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5940

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     6000

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     6060

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     6120

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     6180

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     6240

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     6300

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6360

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6420

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6480

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6540

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6600

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6660

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6720

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6780

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6840

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6900

ttccccgaaa agtgccacct gacgtc                                          6926


<210> 7
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaag                   708


<210> 8
<211> 516
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
atggtcttca cactcgaaga tttcgttggg gactggcgac agacagccgg ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgtttc agaatctcgg ggtgtccgta      120

actccgatcc aaaggattgt cctgagcggt gaaaatgggc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcggcgac caaatgggcc agatcgaaaa aatttttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgcactatgg cacactggta      300

atcgacgggg ttacgccgaa catgatcgac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcaaccc cgacggctcc ctgctgttcc gagtaaccat caacggagtg      480

accggctggc ggctgtgcga acgcattctg gcgtaa                                516


<210> 9
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
gggagccacc atggactaca aggacgacga cgacaagatc atcgactata aagacgacga       60

cgataaaggt ggcgactata aggacgacga cgacaaagcc attaatagtg actctgagtg      120

tcccctgtcc cacgacgggt actgcctcca cgacggtgtg tgcatgtata ttgaagcatt      180

ggacaagtac gcctgcaact gtgttgttgg ctacatcggg gagcgctgtc agtaccgaga      240

cctgaagtgg tgggaactgc gcggaagcgg agctactaac ttcagcctgc tgaagcaggc      300

tggagacgtg gaggagaacc ctggacctct                                       330


<210> 10
<211> 264
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
gggagccacc atggactaca aggacgacga cgacaagatc atcgactata aagacgacga       60

cgataaaggt ggcgactata aggacgacga cgacaaagcc attaatagtg actctgagtg      120

tcccctgtcc cacgacgggt actgcctcca cgacggtgtg tgcatgtata ttgaagcatt      180

ggacaagtac gcctgcaact gtgttgttgg ctacatcggg gagcgctgtc agtaccgaga      240

cctgaagtgg tgggaactgc gcct                                             264


<210> 11
<211> 273
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
gggagccacc atggactaca aggacgacga cgacaagatc atcgactata aagacgacga       60

cgataaaggt ggcgactata aggacgacga cgacaaagcc attaatagtg actctgagtg      120

tcccctgtcc cacgacgggt actgcctcca cgacggtgtg tgcatgtata ttgaagcatt      180

ggacaagtac gcctgcaact gtgttgttgg ctacatcggg gagcgctgtc agtaccgaga      240

cctgaagtgg tgggaactgc gctgatagta act                                   273


<210> 12
<211> 873
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
gggagccacc atggactaca aggacgacga cgacaagatc atcaatagtg actctgagtg       60

tcccctgtcc cacgacgggt actgcctcca cgacggtgtg tgcatgtata ttgaagcatt      120

ggacaagtac gcctgcaact gtgttgttgg ctacatcggg gagcgctgtc agtaccgaga      180

cctgaagtgg tgggaactgc gcggctccgg cgagggcagg ggaagtcttc taacatgcgg      240

ggacgtggag gaaaatcccg gcccagacta taaggacgac gacgacaaaa tcatcgtctt      300

cacactcgaa gatttcgttg gggactggcg acagacagcc ggctacaacc tggaccaagt      360

ccttgaacag ggaggtgtgt ccagtttgtt tcagaatctc ggggtgtccg taactccgat      420

ccaaaggatt gtcctgagcg gtgaaaatgg gctgaagatc gacatccatg tcatcatccc      480

gtatgaaggt ctgagcggcg accaaatggg ccagatcgaa aaaattttta aggtggtgta      540

ccctgtggat gatcatcact ttaaggtgat cctgcactat ggcacactgg taatcgacgg      600

ggttacgccg aacatgatcg actatttcgg acggccgtat gaaggcatcg ccgtgttcga      660

cggcaaaaag atcactgtaa cagggaccct gtggaacggc aacaaaatta tcgacgagcg      720

cctgatcaac cccgacggct ccctgctgtt ccgagtaacc atcaacggag tgaccggctg      780

gcggctgtgc gaacgcattc tggcgggaag cggagctact aacttcagcc tgctgaagca      840

ggctggagac gtggaggaga accctggacc tct                                   873


<210> 13
<211> 762
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
gggagccacc atggactaca aggacgacga cgacaagatc atcaatagtg actctgagtg       60

tcccctgtcc cacgacgggt actgcctcca cgacggtgtg tgcatgtata ttgaagcatt      120

ggacaagtac gcctgcaact gtgttgttgg ctacatcggg gagcgctgtc agtaccgaga      180

cctgaagtgg tgggaactgc gctgatagta agactataag gacgacgacg acaaaatcat      240

cgtcttcaca ctcgaagatt tcgttgggga ctggcgacag acagccggct acaacctgga      300

ccaagtcctt gaacagggag gtgtgtccag tttgtttcag aatctcgggg tgtccgtaac      360

tccgatccaa aggattgtcc tgagcggtga aaatgggctg aagatcgaca tccatgtcat      420

catcccgtat gaaggtctga gcggcgacca aatgggccag atcgaaaaaa tttttaaggt      480

ggtgtaccct gtggatgatc atcactttaa ggtgatcctg cactatggca cactggtaat      540

cgacggggtt acgccgaaca tgatcgacta tttcggacgg ccgtatgaag gcatcgccgt      600

gttcgacggc aaaaagatca ctgtaacagg gaccctgtgg aacggcaaca aaattatcga      660

cgagcgcctg atcaaccccg acggctccct gctgttccga gtaaccatca acggagtgac      720

cggctggcgg ctgtgcgaac gcattctggc gtgatagtaa ct                         762


<210> 14
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
gagggcaggg gaagtctact aacatgcggg gacgtggagg aaaatcccgg ccca             54


<210> 15
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
cagtgtacta attatgctct cttgaaattg gctggagatg ttgagagcaa cccaggtccc       60


<210> 16
<211> 796
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
gtaagaagca aggtttcatt taggggaagg gaaatgattc aggacgagag tctttgtgct       60

gctgagtgcc tgtgatgaag aagcatgtta gtcctgggca acgtagcgag accccatctc      120

tacaaaaaat agaaaaatta gccaggtata gtggcgcaca cctgtgattc cagctacgca      180

ggaggctgag gtgggaggat tgcttgagcc caggaggttg aggctgcagt gagctgtaat      240

catgccacta ctccaacctg ggcaacacag caaggaccct gtctcaaaag ctacttacag      300

aaaagaatta ggctcggcac ggtagctcac acctgtaatc ccagcacttt gggaggctga      360

ggcgggcaga tcacttgagg tcaggagttt gagaccagcc tggccaacat ggtgaaacct      420

tgtctctact aaaaatatga aaattagcca ggcatggtgg cacattcctg taatcccagc      480

tactcgggag gctgaggcag gagaatcact tgaacccagg aggtggaggt tgcagtaagc      540

cgagatcgta ccactgtgct ctagccttgg tgacagagcg agactgtctt aaaaaaaaaa      600

aaaaaaaaaa aagaattaat taaaaattta aaaaaaaatg aaaaaaagct gcatgcttgt      660

tttttgtttt tagttattct acattgttgt cattattacc aaatattggg gaaaatacaa      720

cttacagacc aatctcagga gttaaatgtt actacgaagg caaatgaact atgcgtaatg      780

aacctggtag gcatta                                                      796


<210> 17
<211> 582
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
atgggagtgc acgagtgtcc cgcgtggttg tggttgctgc tgtcgctctt gagcctccca       60

ctgggactgc ctgtgctggg ggcaccaccc agattgatct gcgactcacg ggtacttgag      120

aggtaccttc ttgaagccaa agaagccgaa aacatcacaa ccggatgcgc cgagcactgc      180

tccctcaatg agaacattac tgtaccggat acaaaggtca atttctatgc atggaagaga      240

atggaagtag gacagcaggc cgtcgaagtg tggcaggggc tcgcgctttt gtcggaggcg      300

gtgttgcggg gtcaggccct cctcgtcaac tcatcacagc cgtgggagcc cctccaactt      360

catgtcgata aagcggtgtc ggggctccgc agcttgacga cgttgcttcg ggctctgggc      420

gcacaaaagg aggctatttc gccgcctgac gcggcctccg cggcacccct ccgaacgatc      480

accgcggaca cgtttaggaa gctttttaga gtgtacagca atttcctccg cggaaagctg      540

aaattgtata ctggtgaagc gtgtaggaca ggggatcgct aa                         582


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Ile"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(8)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 18
Asp Val Glu Xaa Asn Pro Gly Pro 
1               5               


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210> 20
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Glu Glu Glu Glu Glu Glu 
1               5       


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 25
His His His His His His 
1               5       


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 27
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Glu Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


<210> 28
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210> 29
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210> 34
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Cys Cys Pro Gly Cys Cys 
1               5       


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Glu Val His Thr Asn Gln Asp Pro Leu Asp 
1               5                   10  


<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 37
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 39
agatttcgtt ggggactggc                                                   20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 40
caccgctcag gacaatcctt                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 41
ctggagacgt ggaggagaac                                                   20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 42
ccaaaagacg gcaatatggt                                                   20


<210> 43
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
gtcaacggat tttcccaagt ccgtagcgtc tc                                     32


<210> 44
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
gtttttcggc tattcccaat agccgttttg                                        30


<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 45
agggctgctt ttaactctgg t                                                 21


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 46
ccccacttga ttttggaggg a                                                 21


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 47
tgtgggcaat gtcatcaaaa                                                   20


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 48
gaagcacttg ctacctcttg c                                                 21


<210> 49
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 49
ggcaccatgg gaagtgatt                                                    19


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 50
atttggtaag gcctgagctg                                                   20


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 51
tcgctggtat cactcgtctg                                                   20


<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 52
gattctgaag accgccagag                                                   20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 53
ctctcctgtt gtgcttctcc                                                   20


<210> 54
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 54
gtcaaagttc atcctgtcct tg                                                22


