                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS AND COMPOSITIONS FOR ALLELE SPECIFIC GENE EDITING

<130> 167705.011501/PCT

<140> PCT/US2020/038516
<141> 2020-06-18

<150> 62/864,933
<151> 2019-06-21

<160> 135   

<170> PatentIn version 3.5

<210> 1
<211> 8543
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
ccaatgatac gcgtcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg       60

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac      120

gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta catcgacggt      180

atcgggggag ctcgcagggt ctccattttg aagcgggagg tttgaacgcg cagccgccat      240

gccggggttt tacgagattg tgattaaggt ccccagcgac cttgacgagc atctgcccgg      300

catttctgac agctttgtga actgggtggc cgagaaggaa tgggagttgc cgccagattc      360

tgacatggat ctgaatctga ttgagcaggc acccctgacc gtggccgaga agctgcagcg      420

cgactttctg acggaatggc gccgtgtgag taaggccccg gaggctcttt tctttgtgca      480

atttgagaag ggagagagct acttccacat gcacgtgctc gtggaaacca ccggggtgaa      540

atccatggtt ttgggacgtt tcctgagtca gattcgcgaa aaactgattc agagaattta      600

ccgcgggatc gagccgactt tgccaaactg gttcgcggtc acaaagacca gaaatggcgc      660

cggaggcggg aacaaggtgg tggatgagtg ctacatcccc aattacttgc tccccaaaac      720

ccagcctgag ctccagtggg cgtggactaa tatggaacag tatttaagcg cctgtttgaa      780

tctcacggag cgtaaacggt tggtggcgca gcatctgacg cacgtgtcgc agacgcagga      840

gcagaacaaa gagaatcaga atcccaattc tgatgcgccg gtgatcagat caaaaacttc      900

agccaggtac atggagctgg tcgggtggct cgtggacaag gggattacct cggagaagca      960

gtggatccag gaggaccagg cctcatacat ctccttcaat gcggcctcca actcgcggtc     1020

ccaaatcaag gctgccttgg acaatgcggg aaagattatg agcctgacta aaaccgcccc     1080

cgactacctg gtgggccagc agcccgtgga ggacatttcc agcaatcgga tttataaaat     1140

tttggaacta aacgggtacg atccccaata tgcggcttcc gtctttctgg gatgggccac     1200

gaaaaagttc ggcaagagga acaccatctg gctgtttggg cctgcaacta ccgggaagac     1260

caacatcgcg gaggccatag cccacactgt gcccttctac gggtgcgtaa actggaccaa     1320

tgagaacttt cccttcaacg actgtgtgga caagatggtg atctggtggg aggaggggaa     1380

gatgaccgcc aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt     1440

ggaccagaaa tgcaagtcct cggcccagat agacccgact cccgtgatcg tcacctccaa     1500

caccaatatg tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt     1560

gcaagaccgg atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt     1620

caccaagcag gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga     1680

gcatgaattc tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga     1740

tataagtgag cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga     1800

agcttcgatc aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa     1860

tctgatgctg tttccctgca gacaatgcga gagactgaat cagaattcaa atatctgctt     1920

cactcacggt gtcaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc     1980

tgtcgtcaaa aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc     2040

agacgcttgc actgcttgcg acctggtcaa tgtggacttg gatgactgtg tttctgaaca     2100

ataaatgact taaaccaggt atgagtcggc tggataaatc taaagtcata aacggcgctc     2160

tggaattact caatgaagtc ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc     2220

tgggagttga gcagcctacc ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg     2280

ccctggccat cgagatgctg gacaggcatc atacccactt ctgccccctg gaaggcgagt     2340

catggcaaga ctttctgcgg aacaacgcca agtcattccg ctgtgctctc ctctcacatc     2400

gcgacggggc taaagtgcat ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg     2460

aaaatcagct cgcgttcctg tgtcagcaag gcttctccct ggagaacgca ctgtacgctc     2520

tgtccgccgt gggccacttt acactgggct gcgtattgga ggaacaggag catcaagtag     2580

caaaagagga aagagagaca cctaccaccg attctatgcc cccacttctg agacaagcaa     2640

ttgagctgtt cgaccggcag ggagccgaac ctgccttcct tttcggcctg gaactaatca     2700

tatgtggcct ggagaaacag ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg     2760

attttgactt agacatgctc ccagccgatg cccttgacga ctttgacctt gatatgctgc     2820

ctgctgacgc tcttgacgat tttgaccttg acatgctccc cgggtaaatg catgaattcg     2880

atctagaggg ccctattcta tagtgtcacc taaatgctag agctcgctga tcagcctcga     2940

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     3000

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     3060

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3120

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     3180

gaaccagctg gggctcgaat caagctatca agtgccacct gacgtctccc tatcagtgat     3240

agagaagtcg acacgtctcg agctccctat cagtgataga gaaggtacgt ctagaacgtc     3300

tccctatcag tgatagagaa gtcgacacgt ctcgagctcc ctatcagtga tagagaaggt     3360

acgtctagaa cgtctcccta tcagtgatag agaagtcgac acgtctcgag ctccctatca     3420

gtgatagaga aggtacgtct agaacgtctc cctatcagtg atagagaagt cgacacgtct     3480

cgagctccct atcagtgata gagaaggtac cccctatata agcagagaga tctgttcaaa     3540

tttgaactga ctaagcggct cccgccagat tttggcaaga ttactaagca ggaagtcaag     3600

gacttttttg cttgggcaaa ggtcaatcag gtgccggtga ctcacgagtt taaagttccc     3660

agggaattgg cgggaactaa aggggcggag aaatctctaa aacgcccact gggtgacgtc     3720

accaatacta gctataaaag tctggagaag cgggccaggc tctcatttgt tcccgagacg     3780

cctcgcagtt cagacgtgac tgttgatccc gctcctctgc gaccgctagc ttcgatcaac     3840

tacgcagaca ggtaccaaaa caagtgttct cgtcacgtgg gcattaatct gattctgttt     3900

ccctgcagac aatgcgagag aatgaatcag aactcaaata tctgcttcac tcacggacag     3960

aaagactgtt tagagtgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcaaaaag     4020

gcgtatcaga aactgtgcta cattcatcat atcatgggaa aggtgccaga cgcttgcact     4080

gcctgcgatc tggtcaatgt ggatttggat gactgcatct ttgaacaata aatgacttaa     4140

gccaggtatg gctgccgatg gttatcttcc agattggctc gaggacaacc ttagtgaagg     4200

aattcgcgag tggtgggctt tgaaacctgg agcccctcaa cccaaggcaa atcaacaaca     4260

tcaagacaac gctagaggtc ttgtgcttcc gggttacaaa taccttggac ccggcaacgg     4320

actcgacaag ggggagccgg tcaacgcagc agacgcggcg gccctcgagc acgacaaagc     4380

ctacgaccag cagctcaagg ccggagacaa cccgtacctc aagtacaacc acgccgacgc     4440

cgagttccag gagcggctca aagaagatac gtcttttggg ggcaacctcg ggcgagcagt     4500

cttccaggcc aaaaagaggc ttcttgaacc tcttggtctg gttgaggaag cggctaagac     4560

ggctcctgga aagaagaggc ctgtagagca gtctcctcag gaaccggact cctccgcggg     4620

tattggcaaa tcgggtgcac agcccgctaa aaagagactc aatttcggtc agactggcga     4680

cacagagtca gtcccagacc ctcaaccaat cggagaacct cccgcagccc cctcaggtgt     4740

gggatctctt acaatggctt caggtggtgg cgcaccagtg gcagacaata acgaaggtgc     4800

cgatggagtg ggtagttcct cgggaaattg gcattgcgat tcccaatggc tgggggacag     4860

agtcatcacc accagcaccc gaacctgggc cctgcccacc tacaacaatc acctctacaa     4920

gcaaatctcc aacagcacat ctggaggatc ttcaaatgac aacgcctact tcggctacag     4980

caccccctgg gggtattttg acttcaacag attccactgc cacttctcac cacgtgactg     5040

gcagcgactc atcaacaaca actggggatt ccggcctaag cgactcaact tcaagctctt     5100

taacattcag gtcaaagagg ttacggacaa caatggagtc aagaccatcg ccaataacct     5160

taccagcacg gtccaggtct tcacggactc agactatcag ctcccgtacg tgctcgggtc     5220

ggctcacgag ggctgcctcc cgccgttccc agcggacgtt ttcatgattc ctcagtacgg     5280

gtatctgacg cttaatgatg gaagccaggc cgtgggtcgt tcgtcctttt actgcctgga     5340

atatttcccg tcgcaaatgc taagaacggg taacaacttc cagttcagct acgagtttga     5400

gaacgtacct ttccatagca gctacgctca cagccaaagc ctggaccgac taatgaatcc     5460

actcatcgac caatacttgt actatctctc tagaactatt aacggttctg gacagaatca     5520

acaaacgcta aaattcagtg tggccggacc cagcaacatg gctgtccagg gaagaaacta     5580

catacctgga cccagctacc gacaacaacg tgtctcaacc actgtgactc aaaacaacaa     5640

cagcgaattt gcttggcctg gagcttcttc ttgggctctc aatggacgta atagcttgat     5700

gaatcctgga cctgctatgg cctctcacaa agaaggagag gaccgtttct ttcctttgtc     5760

tggatcttta atttttggca aacaaggtac tggcagagac aacgtggatg cggacaaagt     5820

catgataacc aacgaagaag aaattaaaac tactaacccg gtagcaacgg agtcctatgg     5880

acaagtggcc acaaaccacc agagtgccca aactttggcg gtgcctttta aggcacaggc     5940

gcagaccggt tgggttcaaa accaaggaat acttccgggt atggtttggc aggacagaga     6000

tgtgtacctg caaggaccca tttgggccaa aattcctcac acggacggca actttcaccc     6060

ttctccgctg atgggagggt ttggaatgaa gcacccgcct cctcagatcc tcatcaaaaa     6120

cacacctgta cctgcggatc ctccaacggc cttcaacaag gacaagctga actctttcat     6180

cacccagtat tctactggtc aagtcagcgt ggagatcgag tgggagctgc agaaggaaaa     6240

cagcaagcgc tggaacccgg agatccagta cacttccaac tattacaagt ctaataatgt     6300

tgaatttgct gttaatactg aaggtgtata tagtgaaccc cgccccattg gcaccagata     6360

cctgactcgt aatctgtaag tcgacttgct tgttaatcaa taaaccgttt aattcgtttc     6420

agttgaactt tggtctctgc gaagggcaat tcgtttaaac ctgcaggact agaggtcctg     6480

tattagaggt cacgtgagtg ttttgcgaca ttttgcgaca ccatgtggtc acgctgggta     6540

tttaagcccg agtgagcacg cagggtctcc attttgaagc gggaggtttg aacgcgcagc     6600

cgccaagccg aattctgcag atatcacatg tcctaggaac tatcgatcca tcacactggc     6660

ggccgctcga ctagagcggc cgccaccgcg gtggagctcc agcttttgcg gaccgaatcg     6720

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     6780

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     6840

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     6900

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     6960

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     7020

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     7080

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     7140

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     7200

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     7260

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     7320

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     7380

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     7440

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     7500

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     7560

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     7620

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     7680

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     7740

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     7800

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     7860

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     7920

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     7980

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     8040

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     8100

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     8160

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     8220

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     8280

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     8340

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     8400

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     8460

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     8520

cccgaaaagt gccacctgac gtc                                             8543


<210> 2
<211> 734
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Anc80 sequence

<400> 2
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Gln Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Thr Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Gln Thr Thr Ser Gly Thr Ala Gly Asn Arg Thr Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Thr Asn Gln Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Thr His Lys Asp 
        515                 520                 525             


Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ala Gly Asn Ser Asn Val Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Thr Val Ala Thr Asn Leu Gln Ser Ala Asn Thr Ala Pro Ala Thr 
            580                 585                 590         


Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Thr Asn Val Asp Phe Ala Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 3
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 3
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 4
<211> 4107
<212> DNA
<213> Streptococcus pyogenes

<400> 4
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210> 5
<211> 1087
<212> PRT
<213> Staphylococcus aureus

<400> 5
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
            20                  25                  30          


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
        35                  40                  45              


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
    50                  55                  60                  


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
65                  70                  75                  80  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
                85                  90                  95      


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
            100                 105                 110         


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
        115                 120                 125             


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
    130                 135                 140                 


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
145                 150                 155                 160 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
                165                 170                 175     


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
            180                 185                 190         


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
        195                 200                 205             


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
    210                 215                 220                 


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
225                 230                 235                 240 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
                245                 250                 255     


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
            260                 265                 270         


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
        275                 280                 285             


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
    290                 295                 300                 


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
305                 310                 315                 320 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
                325                 330                 335     


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
            340                 345                 350         


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
        355                 360                 365             


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
    370                 375                 380                 


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
385                 390                 395                 400 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
                405                 410                 415     


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
            420                 425                 430         


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
        435                 440                 445             


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
    450                 455                 460                 


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
                485                 490                 495     


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
            500                 505                 510         


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
        515                 520                 525             


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
    530                 535                 540                 


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
                565                 570                 575     


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
            580                 585                 590         


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
        595                 600                 605             


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
    610                 615                 620                 


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
625                 630                 635                 640 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
                645                 650                 655     


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
            660                 665                 670         


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
        675                 680                 685             


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
    690                 695                 700                 


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
705                 710                 715                 720 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
                725                 730                 735     


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
            740                 745                 750         


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
        755                 760                 765             


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
    770                 775                 780                 


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
785                 790                 795                 800 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
                805                 810                 815     


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
            820                 825                 830         


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
        835                 840                 845             


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
    850                 855                 860                 


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
865                 870                 875                 880 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
                885                 890                 895     


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
            900                 905                 910         


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
        915                 920                 925             


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
    930                 935                 940                 


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
945                 950                 955                 960 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
                965                 970                 975     


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
            980                 985                 990         


Glu Leu Tyr Arg Val Ile Gly Val  Asn Asn Asp Leu Leu  Asn Arg Ile 
        995                 1000                 1005             


Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
    1010                 1015                 1020             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1025                 1030                 1035             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1040                 1045                 1050             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1055                 1060                 1065             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1070                 1075                 1080             


Lys Lys  Gly Ser 
    1085         


<210> 6
<211> 1087
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
            20                  25                  30          


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
        35                  40                  45              


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
    50                  55                  60                  


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
65                  70                  75                  80  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
                85                  90                  95      


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
            100                 105                 110         


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
        115                 120                 125             


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
    130                 135                 140                 


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
145                 150                 155                 160 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
                165                 170                 175     


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
            180                 185                 190         


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
        195                 200                 205             


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
    210                 215                 220                 


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
225                 230                 235                 240 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
                245                 250                 255     


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
            260                 265                 270         


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
        275                 280                 285             


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
    290                 295                 300                 


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
305                 310                 315                 320 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
                325                 330                 335     


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
            340                 345                 350         


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
        355                 360                 365             


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
    370                 375                 380                 


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
385                 390                 395                 400 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
                405                 410                 415     


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
            420                 425                 430         


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
        435                 440                 445             


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
    450                 455                 460                 


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
                485                 490                 495     


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
            500                 505                 510         


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
        515                 520                 525             


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
    530                 535                 540                 


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
                565                 570                 575     


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
            580                 585                 590         


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
        595                 600                 605             


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
    610                 615                 620                 


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
625                 630                 635                 640 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
                645                 650                 655     


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
            660                 665                 670         


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
        675                 680                 685             


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
    690                 695                 700                 


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
705                 710                 715                 720 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
                725                 730                 735     


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
            740                 745                 750         


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
        755                 760                 765             


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
    770                 775                 780                 


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
785                 790                 795                 800 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
                805                 810                 815     


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
            820                 825                 830         


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
        835                 840                 845             


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
    850                 855                 860                 


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
865                 870                 875                 880 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
                885                 890                 895     


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
            900                 905                 910         


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
        915                 920                 925             


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
    930                 935                 940                 


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
945                 950                 955                 960 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
                965                 970                 975     


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
            980                 985                 990         


Glu Leu Tyr Arg Val Ile Gly Val  Asn Asn Asp Leu Leu  Asn Arg Ile 
        995                 1000                 1005             


Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
    1010                 1015                 1020             


Met Asn  Asp Lys Arg Pro Pro  His Ile Ile Lys Thr  Ile Ala Ser 
    1025                 1030                 1035             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1040                 1045                 1050             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1055                 1060                 1065             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1070                 1075                 1080             


Lys Lys  Gly Ser 
    1085         


<210> 7
<211> 964
<212> DNA
<213> Homo sapiens

<400> 7
tcttcacctg tcattttcaa ccagcctcag cctatctgct ctgtcacaat cactactaaa       60

atatgttcct aaattgcttg tttctagatc cttccttctc atatgctcag gtgaacacat      120

gggtgaaatt taatatggaa ttgaaatatg tactatgcaa gatagattcc ttaagaaatg      180

tttctctgat ttatatgaca taattgtatt ttactagttt acctgtccat ctgtaaaact      240

ttgttttgga gatttcatat attacaatgt ttaagaaata tgctataatg ttttgtatag      300

tatatttctt cgtgataacc ttatatacta ccagtcacac gtgtttgtaa aaatctaaag      360

agtacttttg gctcctacag aatgtgtgaa gttgtgaaat tgtttttttg ttttgttttg      420

ttttgttttt atgccccaaa gatgtggagg gcttcatata agagggtaga tttaatgaga      480

gagagaggga gagacagaga gaatgataaa agaagcttaa gagattattt tatcttgtca      540

acgacattgt tattgaatgt aagctgctaa acttcttaga taaagtaaaa cagtaaaaac      600

aaacacacaa aacagaacag agaatcatca gacaggctga cgaacacagt acaataaagc      660

agccagtacc gatgatcagt ggacatcaat ttgtcttttg ggctgtagca cctgctacta      720

attggtgcaa agcgctcacc agtcagtgcg tggtttagcg cactcagctg tctcctgtat      780

gtgctgcgag aagcaagata gctaattgct gttgcttcag tgccagtgaa atcaacgtgc      840

tgagctaata gcgacagata gagggcagac agattcctgc tagcagctta gtgttagttg      900

cttgtggtaa ctaaggcagg tggcatacat ctcagaacgt ggagaatgat ggtatgcttt      960

ctga                                                                   964


<210> 8
<211> 1040
<212> DNA
<213> Homo sapiens

<400> 8
tggtagcctc cctagagaca cagagctggg ccggatgagt ccaggcactg acgtgatcca       60

ttatctttca ccttaaagag taaaagggaa actaaagtta attacctcca cgaaacaaaa      120

aggtgccttc ttgtgcttca attacatgga tatattctac tagtctaaaa gtatcttctc      180

acttctttct gtcactgtga ggacttgagt cagaagaaag tttaaataca gtcattgagc      240

tggaaagagt ggaaagagaa gcaaagaggg ggaagctgta ggaaggacga agtcaccccc      300

aagatacatg gttactgctt acaccaagca agctgccttg ggaacgcttc ccccgagcag      360

ccagaatgct cagcagtgga agacacctct attcctgtag gcgagtcctg ggaagctggt      420

caatctgcaa atgccaattc ccagcagtga gctcggtcca cgtgtaaatc aagatttggg      480

gaaagagtag ggtgggtggc atggttgaca atgtcatcag ctccctcctc tgactcctgt      540

ggtcgtgccc ccatctactc tcactcagct acaccccacc ttcggatttg tgatggacgc      600

tgggtcccta gtaaccacag caagtgtctc ccccgcactt cccccttccc cacccccacc      660

cccaccccca accaccaccc cagcgatgga gcctactctg ctccaagccg ccgctaagac      720

ccggagaagc ggaatttcac tttgaaattc ccttgcctcg tgagggccgg cgctgggcat      780

gctcagtagc cgcggcgctg ctgctgggct gctgggctgg cgcggagtcc accctgccgt      840

ctccgccttg gcttctgggc gtccagaagg ccaggcattt gccgcctctg agcgcttctg      900

ttccccttac ccgcaacctc ctactgctct tcctctctcc ctctcttagg gaggttgaag      960

ctggtgctgg tttctgtcgg cgccacagac tgactgctct gcaaacccca gccgaggacc     1020

tgaatcccgg agactagaag                                                 1040


<210> 9
<211> 964
<212> DNA
<213> Homo sapiens

<400> 9
gcccagtgga attttcctag ttctttacac tagccatgta tttacctata aaatcaggag       60

aaatatgtat atatataata tattaaaaca tatatatatt taaatgggga aatatgtaac      120

aaacaaatag aaacaagggg agaaaggcat tgtatttgac aaaacacata tgttcaggtc      180

tgagaaggct cataaagaat gttgtctgct atactttgta gttgcttctg ttatcacaca      240

atcagtctgc atatacaggc gttttatata tatatttata tagactacat atatacgtat      300

attatatatg taaatatttc actgtctttg aggacggggg ccctgtcttt tttatctgtg      360

gttttgctta gatgtcctcc aacataatct taacacatag tatgctttta gaaatcgttg      420

actgaatgct aaggacgaaa aaccggtgac cagaaggcaa ccaggaaagg ctttgctgac      480

ctccggagtg gtggagttgg aggttctggg aaggcgacta gggagccagg caggggcggg      540

gtgggatggg atgtggacag cgcttttgcg gggggaaagc gtttttgctg ctggaattga      600

gcagtaggaa tgtgtcagtc acatccccac cttcccaatt cttgtcatct cggttcagga      660

aggtgaacgg tgttccgatt ccccgcggcg ggggcctgta gtgggagctc tgccccttcc      720

ccgcctctgc tgcaggcccc gcccctcgcc cggaaccccg gggcgctggc cgcggtgctg      780

aaacggcgcc ctccgcggac ggaggagggg gcggggctct cgggagccgt gagccgggaa      840

gagggagacg ggcagggcgg cgccagcagg ccctggtggg cttgggagga ggcaggagac      900

tggagacagc ctcggctaga gcggacacag gcacctggca agctttcctt gaccaaatca      960

aggt                                                                   964


<210> 10
<211> 477
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Synapsin promoter sequence

<400> 10
tctagactgc agagggccct gcgtatgagt gcaagtgggt tttaggacca ggatgaggcg       60

gggtgggggt gcctacctga cgaccgaccc cgacccactg gacaagcacc caacccccat      120

tccccaaatt gcgcatcccc tatcagagag ggggagggga aacaggatgc ggcgaggcgc      180

gtgcgcactg ccagcttcag caccgcggac agtgccttcg cccccgcctg gcggcgcgcg      240

ccaccgccgc ctcagcactg aaggcgcgct gacgtcactc gccggtcccc cgcaaactcc      300

ccttcccggc caccttggtc gcgtccgcgc cgccgccggc ccagccggac cgcaccacgc      360

gaggcgcgag ataggggggc acgggcgcga ccatctgcgc tgcggcgccg gcgactcagc      420

gctgcctcag tctgcggtgg gcagcggagg agtcgtgtcg tgcctgagag cgcagtc         477


<210> 11
<211> 760
<212> PRT
<213> Homo sapiens

<400> 11
Met Ser Pro Lys Lys Val Gln Ile Lys Val Glu Glu Lys Glu Asp Glu 
1               5                   10                  15      


Thr Glu Glu Ser Ser Ser Glu Glu Glu Glu Glu Val Glu Asp Lys Leu 
            20                  25                  30          


Pro Arg Arg Glu Ser Leu Arg Pro Lys Arg Lys Arg Thr Arg Asp Val 
        35                  40                  45              


Ile Asn Glu Asp Asp Pro Glu Pro Glu Pro Glu Asp Glu Glu Thr Arg 
    50                  55                  60                  


Lys Ala Arg Glu Lys Glu Arg Arg Arg Arg Leu Lys Arg Gly Ala Glu 
65                  70                  75                  80  


Glu Glu Glu Ile Asp Glu Glu Glu Leu Glu Arg Leu Lys Ala Glu Leu 
                85                  90                  95      


Asp Glu Lys Arg Gln Ile Ile Ala Thr Val Lys Cys Lys Pro Trp Lys 
            100                 105                 110         


Met Glu Lys Lys Ile Glu Val Leu Lys Glu Ala Lys Lys Phe Val Ser 
        115                 120                 125             


Glu Asn Glu Gly Ala Leu Gly Lys Gly Lys Gly Lys Arg Trp Phe Ala 
    130                 135                 140                 


Phe Lys Met Met Met Ala Lys Lys Trp Ala Lys Phe Leu Arg Asp Phe 
145                 150                 155                 160 


Glu Asn Phe Lys Ala Ala Cys Val Pro Trp Glu Asn Lys Ile Lys Ala 
                165                 170                 175     


Ile Glu Ser Gln Phe Gly Ser Ser Val Ala Ser Tyr Phe Leu Phe Leu 
            180                 185                 190         


Arg Trp Met Tyr Gly Val Asn Met Val Leu Phe Ile Leu Thr Phe Ser 
        195                 200                 205             


Leu Ile Met Leu Pro Glu Tyr Leu Trp Gly Leu Pro Tyr Gly Ser Leu 
    210                 215                 220                 


Pro Arg Lys Thr Val Pro Arg Ala Glu Glu Ala Ser Ala Ala Asn Phe 
225                 230                 235                 240 


Gly Val Leu Tyr Asp Phe Asn Gly Leu Ala Gln Tyr Ser Val Leu Phe 
                245                 250                 255     


Tyr Gly Tyr Tyr Asp Asn Lys Arg Thr Ile Gly Trp Met Asn Phe Arg 
            260                 265                 270         


Leu Pro Leu Ser Tyr Phe Leu Val Gly Ile Met Cys Ile Gly Tyr Ser 
        275                 280                 285             


Phe Leu Val Val Leu Lys Ala Met Thr Lys Asn Ile Gly Asp Asp Gly 
    290                 295                 300                 


Gly Gly Asp Asp Asn Thr Phe Asn Phe Ser Trp Lys Val Phe Thr Ser 
305                 310                 315                 320 


Trp Asp Tyr Leu Ile Gly Asn Pro Glu Thr Ala Asp Asn Lys Phe Asn 
                325                 330                 335     


Ser Ile Thr Met Asn Phe Lys Glu Ala Ile Thr Glu Glu Lys Ala Ala 
            340                 345                 350         


Gln Val Glu Glu Asn Val His Leu Ile Arg Phe Leu Arg Phe Leu Ala 
        355                 360                 365             


Asn Phe Phe Val Phe Leu Thr Leu Gly Gly Ser Gly Tyr Leu Ile Phe 
    370                 375                 380                 


Trp Ala Val Lys Arg Ser Gln Glu Phe Ala Gln Gln Asp Pro Asp Thr 
385                 390                 395                 400 


Leu Gly Trp Trp Glu Lys Asn Glu Met Asn Met Val Met Ser Leu Leu 
                405                 410                 415     


Gly Met Phe Cys Pro Thr Leu Phe Asp Leu Phe Ala Glu Leu Glu Asp 
            420                 425                 430         


Tyr His Pro Leu Ile Ala Leu Lys Trp Leu Leu Gly Arg Ile Phe Ala 
        435                 440                 445             


Leu Leu Leu Gly Asn Leu Tyr Val Phe Ile Leu Ala Leu Met Asp Glu 
    450                 455                 460                 


Ile Asn Asn Lys Ile Glu Glu Glu Lys Leu Val Lys Ala Asn Ile Thr 
465                 470                 475                 480 


Leu Trp Glu Ala Asn Met Ile Lys Ala Tyr Asn Ala Ser Phe Ser Glu 
                485                 490                 495     


Asn Ser Thr Gly Pro Pro Phe Phe Val His Pro Ala Asp Val Pro Arg 
            500                 505                 510         


Gly Pro Cys Trp Glu Thr Met Val Gly Gln Glu Phe Val Arg Leu Thr 
        515                 520                 525             


Val Ser Asp Val Leu Thr Thr Tyr Val Thr Ile Leu Ile Gly Asp Phe 
    530                 535                 540                 


Leu Arg Ala Cys Phe Val Arg Phe Cys Asn Tyr Cys Trp Cys Trp Asp 
545                 550                 555                 560 


Leu Glu Tyr Gly Tyr Pro Ser Tyr Thr Glu Phe Asp Ile Ser Gly Asn 
                565                 570                 575     


Val Leu Ala Leu Ile Phe Asn Gln Gly Met Ile Trp Met Gly Ser Phe 
            580                 585                 590         


Phe Ala Pro Ser Leu Pro Gly Ile Asn Ile Leu Arg Leu His Thr Ser 
        595                 600                 605             


Met Tyr Phe Gln Cys Trp Ala Val Met Cys Cys Asn Val Pro Glu Ala 
    610                 615                 620                 


Arg Val Phe Lys Ala Ser Arg Ser Asn Asn Phe Tyr Leu Gly Met Leu 
625                 630                 635                 640 


Leu Leu Ile Leu Phe Leu Ser Thr Met Pro Val Leu Tyr Met Ile Val 
                645                 650                 655     


Ser Leu Pro Pro Ser Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn Arg 
            660                 665                 670         


Met Phe Glu Val Ile Gly Glu Thr Leu Glu His Asp Phe Pro Ser Trp 
        675                 680                 685             


Met Ala Lys Ile Leu Arg Gln Leu Ser Asn Pro Gly Leu Val Ile Ala 
    690                 695                 700                 


Val Ile Leu Val Met Val Leu Ala Ile Tyr Tyr Leu Asn Ala Thr Ala 
705                 710                 715                 720 


Lys Gly Gln Lys Ala Ala Asn Leu Asp Leu Lys Lys Lys Met Lys Met 
                725                 730                 735     


Gln Ala Leu Glu Asn Lys Met Arg Asn Lys Lys Met Ala Ala Ala Arg 
            740                 745                 750         


Ala Ala Ala Ala Ala Gly Arg Gln 
        755                 760 


<210> 12
<211> 3201
<212> DNA
<213> Homo sapiens

<400> 12
cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt       60

tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc cagatgggat      120

cttactctgt tgcccaggct ggagtgcagt ggtgcgatct cggctctctg caacctccgc      180

ctcccaggtt caagtgattc tcctgcctcg gcctcctgag tagctgggat ttcaggccat      240

gaaagatcac tgttttagtc tgcgtggtgc agtggaacag atagacctcg gtttgaatct      300

cagctctact gtttactaga catgaaatgg ggaaatctaa aatgagatgc cagaagcctc      360

aaaaatggaa aaccccctgt gcttcacatc tgaaaatctc tgctgggggc agcaactttg      420

agcctgtggg gaaggaactg tccacgtgga gtggtctggt gaatgcttaa ggagctgcag      480

aagggaagtc cctctccaaa ctagccagcc actgagacct tctgacagga cacccccagg      540

atgtcaccca aaaaagtaca aatcaaagtg gaggaaaaag aagacgagac tgaggaaagc      600

tcaagtgaag aggaagagga ggtggaagat aagctacctc gaagagagag cttgagacca      660

aagaggaaac ggaccagaga tgttatcaat gaggatgacc cagaacctga accagaggat      720

gaagaaacaa ggaaggcaag agaaaaagag aggaggagga ggctaaagag aggagcagaa      780

gaagaagaaa ttgatgaaga ggaattggaa agattgaagg cagagttaga tgagaaaaga      840

caaataattg ctactgtcaa atgcaaacca tggaagatgg agaagaaaat tgaagttctc      900

aaggaggcaa aaaaatttgt gagtgaaaat gaaggggctc ttgggaaagg aaaaggaaaa      960

cggtggtttg catttaagat gatgatggcc aagaaatggg caaaattcct ccgtgatttt     1020

gagaacttca aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtcag     1080

tttggctcct cagtggcctc atacttcctc ttcttgagat ggatgtatgg agtcaatatg     1140

gttctcttta tcctgacatt tagcctcatc atgttgccag agtacctctg gggtttgcca     1200

tatggcagtt tacctaggaa aaccgttccc agagccgaag aggcatcggc agcaaacttt     1260

ggtgtgttgt acgacttcaa tggtttggca caatattccg ttctctttta tggctattat     1320

gacaataaac gaacaattgg atggatgaat ttcaggttgc cgctctccta ttttctagtg     1380

gggattatgt gcattggata cagctttctg gttgtcctca aagcaatgac caaaaacatt     1440

ggtgatgatg gaggtggaga tgacaacact ttcaatttca gctggaaggt ctttaccagc     1500

tgggactacc tgatcggcaa tcctgaaaca gcagacaaca aatttaattc tatcacaatg     1560

aactttaagg aagctatcac agaagaaaaa gcagcccaag tagaagaaaa cgtccacttg     1620

atcagattcc tgaggtttct ggctaacttc ttcgtgtttc taacacttgg agggagtgga     1680

tacctcatct tttgggctgt gaagcgatcc caggaatttg cacagcaaga tcctgacacc     1740

cttgggtggt gggaaaaaaa tgaaatgaac atggttatgt ccctcctagg gatgttctgt     1800

ccaacattgt ttgacttatt tgctgaatta gaagactacc atcctctcat cgctttgaaa     1860

tggctactgg gacgcatttt tgctcttctt ttaggcaatt tatacgtatt tattcttgca     1920

ttaatggatg agattaacaa caagattgaa gaggagaagc tagtaaaggc caatattacc     1980

ctttgggaag ccaatatgat caaggcctac aatgcatcat tctctgaaaa tagcactgga     2040

ccaccctttt ttgttcaccc tgcagatgta cctcgaggac cttgctggga aacaatggtg     2100

ggacaggagt ttgtgaggct gacagtctct gatgttctga ccacctacgt cacaatcctc     2160

attggggact ttctaagggc atgttttgtg aggttttgca attattgctg gtgctgggac     2220

ttggagtatg gatatccttc atacaccgaa ttcgacatca gtggcaacgt cctcgctctg     2280

atcttcaacc aaggcatgat ctggatgggc tccttctttg ctcccagcct cccaggcatc     2340

aatatccttc gactccatac atccatgtac ttccagtgct gggccgttat gtgctgcaat     2400

gttcctgagg ccagggtctt caaagcttcc agatcaaata acttctacct gggcatgcta     2460

ctgctcatcc tcttcctgtc cacaatgcct gtcttgtaca tgatcgtgtc cctcccacca     2520

tcttttgatt gtggtccatt cagtggcaaa aatagaatgt ttgaagtcat tggagagacc     2580

ctggagcacg atttcccaag ctggatggcg aagatcttga gacagctttc aaaccctggg     2640

ctggtcattg ctgtcatttt ggtgatggtt ttggccatct attatctcaa tgctactgcc     2700

aagggccaga aggcagcgaa tctggatctc aaaaagaaga tgaaaatgca agctttggag     2760

aacaaaatgc gaaacaagaa aatggcagct gcacgagcag ctgcagctgc tggtcgccag     2820

taataagtat cctgagagcc cagaaaaggt acactttgcc ttgctgttta aaagtaatgc     2880

aatatgtgaa cgcccagaga acaagcactg tggaactgct attttcctgt tctacccttg     2940

atggattttc aaggtcatgc tggccaatta aggcatcatc agtcctacct gagcaacaag     3000

aatctaaact ttattccaag tcagaaactg tttctgcaga gccactctct cccctgctcc     3060

atttcgtgac tttttttttt tttttaacaa attgagttta gaagtgagtg taatccagca     3120

atacagttta ctggtttagt tggtgggtta attaaaaaaa atttgctcat atgaactttc     3180

attttatatg tttcttttgc c                                               3201


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
gactatcata tgcttaccgt                                                   20


<210> 14
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      AAV-PHP.B sequence

<400> 14
Thr Leu Ala Val Pro Phe Lys 
1               5           


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gggtgggaca gaacttcccc agg                                               23


<210> 16
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ggtgggacag aacttcccca gg                                                22


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gtgggacaga acttccccag g                                                 21


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gggacagaac ttccccagg                                                    19


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gtgggacaga acttccccag gagg                                              24


<210> 20
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gggacagaac ttccccagga gg                                                22


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ggacagaact tccccaggag g                                                 21


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gacagaactt ccccaggagg                                                   20


<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gtggtaatgt ccctcctggg gaag                                              24


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
ggtaatgtcc ctcctgggga ag                                                22


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gtaatgtccc tcctggggaa g                                                 21


<210> 26
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gaacatggta atgtccctcc tggggaagt                                         29


<210> 27
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gacatggtaa tgtccctcct ggggaagt                                          28


<210> 28
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
gcatggtaat gtccctcctg gggaagt                                           27


<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gggtgggaca gaacatcccc agg                                               23


<210> 30
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
gaacatggtt atgtccctcc tagggaagt                                         29


<210> 31
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gacatggtta tgtccctcct agggaagt                                          28


<210> 32
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
gcatggttat gtccctccta gggaagt                                           27


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
taaagggacc gctctgaaaa                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
ccatcaaggc gagaatgaat                                                   20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
acctcatctt ttgggctgtg                                                   20


<210> 36
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
tgggacagaa ca                                                           12


<210> 37
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
tgttctgtcc ca                                                           12


<210> 38
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
tgggacagaa ct                                                           12


<210> 39
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
agttctgtcc ca                                                           12


<210> 40
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
catccccagg aggg                                                         14


<210> 41
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
ccctcctggg gatg                                                         14


<210> 42
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
cttccccagg aggg                                                         14


<210> 43
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
ccctcctggg gaag                                                         14


<210> 44
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
gtttaattga gttgtcatat gttaataacg gtat                                   34


<210> 45
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
ataccgttat taacatatga caactcaatt aaac                                   34


<210> 46
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
tccctcctag ggaagttc                                                     18


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
catcgctttg aaatggctac                                                   20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
aaccatgttc atctacaagg                                                   20


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
agcctagctc agaatcttcc a                                                 21


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
aaaatgcgtc ccagtagcca                                                   20


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
aaaatgcgtc caagtagcca                                                   20


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
ggaaccccta gtgatggagt t                                                 21


<210> 53
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
cggcctcagt gagcga                                                       16


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 54
cactccctct ctgcgcgctc g                                                 21


<210> 55
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
tgaaacatac gttcccaaag agttt                                             25


<210> 56
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
ctctccttct cagaaagtgt gcatat                                            26


<210> 57
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 57
tgctgaaaca ttcaccttcc atgcaga                                           27


<210> 58
<211> 47
<212> DNA
<213> Mus sp.

<400> 58
atgaacatgg taatgtccct cctggggaag ttctgtccca ccctgtt                     47


<210> 59
<211> 40
<212> DNA
<213> Mus sp.

<400> 59
gaacatggta atgtccctcc tggggaagtt ctgtcccacc                             40


<210> 60
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
gaacatggta atgtccctcc ggggaagttc tgtcccacc                              39


<210> 61
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
gaacatggta atgtccctct ggggaagttc tgtcccacc                              39


<210> 62
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
gaacatggaa atgtccctcc tggggaagtt ctgtcccacc                             40


<210> 63
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
gaacatggta attggggaag ttctgtccca cc                                     32


<210> 64
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
gaacatggta atgtccctgg ggaagttctg tcccacc                                37


<210> 65
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
gaacatggca atgtccctcc tggggaagtt ctgtcccacc                             40


<210> 66
<211> 40
<212> DNA
<213> Mus sp.

<400> 66
gaacatggta atgtccctcc tggggatgtt ctgtcccacc                             40


<210> 67
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
gaacatggaa atgtccctcc tggggatgtt ctgtcccacc                             40


<210> 68
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (22)..(24)
<223> a, c, t, g, unknown or other

<400> 68
acatggtaat gtccctcctg gnnnrrt                                           27


<210> 69
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
gaacatggta atgtccctcc ttggggaagt tctgtcccac                             40


<210> 70
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
gaacatggta atgtccctcc atggggaagt tctgtcccac                             40


<210> 71
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
gaacatggta atgtcccttg gggaagttct gtcccacc                               38


<210> 72
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
gaacatggta atgtccctcc gaagttctgt cccacc                                 36


<210> 73
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
gaacatgata atgtccctcc tggggaagtt ctgtcccacc                             40


<210> 74
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
gaacatggta atgtcactcc tggggaagtt ctgtcccacc                             40


<210> 75
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
gaacatggta atgttcctcc tggggaagtt ctgtcccacc                             40


<210> 76
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
gaacatggta atgtccctcc tgaggaagtt ctgtcccacc                             40


<210> 77
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
gaacatggta atgtccctac tggggaagtt ctgtcccacc                             40


<210> 78
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
gaacatgata atgtccctcc tggggatgtt ctgtcccacc                             40


<210> 79
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
gaacatggta atgttcctcc tggggatgtt ctgtcccacc                             40


<210> 80
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
gaacatggta atgtcccccc tggggatgtt ctgtcccacc                             40


<210> 81
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
gaacatggta atgtacctcc tggggatgtt ctgtcccacc                             40


<210> 82
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
gaacatggta ctgtccctcc tggggatgtt ctgtcccacc                             40


<210> 83
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
gaacatggta atgtccctcc cggggatgtt ctgtcccacc                             40


<210> 84
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
gaacatggtt atgtccctcc tggggatgtt ctgtcctacg                             40


<210> 85
<211> 47
<212> DNA
<213> Homo sapiens

<400> 85
atgaacatgg ttatgtccct cctagggaag ttctgtccaa cattgtt                     47


<210> 86
<211> 40
<212> DNA
<213> Homo sapiens

<400> 86
gaacatggtt atgtccctcc tagggaagtt ctgtccaaca                             40


<210> 87
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
gaacatggtt atgtccctcc agggaagttc tgtccaaca                              39


<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
gaacatggtt atgtccaaca                                                   20


<210> 89
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
gaacatggtt atgtccctag ggaagttctg tccaaca                                37


<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
gaacatggtt ctgtccaaca                                                   20


<210> 91
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
gaacatggtt agggaagttc tgtccaaca                                         29


<210> 92
<211> 40
<212> DNA
<213> Homo sapiens

<400> 92
gaacatggtt atgtccctcc tagggatgtt ctgtccaaca                             40


<210> 93
<211> 44
<212> DNA
<213> Mus sp.

<400> 93
aacatggtaa tgtccctcct ggggaagttc tgtcccaccc tgtt                        44


<210> 94
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
tgggacagaa cttccccagg agggacatta ccatgt                                 36


<210> 95
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (26)..(26)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (29)..(30)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (32)..(36)
<223> a, c, t, g, unknown or other

<400> 95
tgggacagaa cntcccnngn ngnaanttnn cnnnnn                                 36


<210> 96
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
tgggacagaa catccccagg agggacatta ccatgt                                 36


<210> 97
<211> 40
<212> DNA
<213> Mus sp.

<400> 97
aacatggtaa tgtccctcct ggggaagttc tgtcccaccc                             40


<210> 98
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
aacatggtaa tgtccctccg gggaagttct gtcccaccc                              39


<210> 99
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
aacatggtaa tgtccctcct gggaagttct gtcccaccc                              39


<210> 100
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
aacatggtaa tgtccctcct ggaagttctg tcccaccc                               38


<210> 101
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
aacatggtaa tgtccctcct gggggaagtt ctgtcccacc                             40


<210> 102
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
aacatggtaa tgtccctcgg ggaagttctg tcccaccc                               38


<210> 103
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
aacatggtaa tgtccctcct agttctgtcc caccc                                  35


<210> 104
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
aacatggtaa tgtccctcct gagttctgtc ccaccc                                 36


<210> 105
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
acatggtaat gtccctcctt ggggaagttc tgtcccaccc                             40


<210> 106
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
aacatggtaa tgtccctcct aagttctgtc ccaccc                                 36


<210> 107
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
aacatggtaa tgtccctcct tggggaagtt ctgtcccacc                             40


<210> 108
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
aacatggtaa tgtcccgggg aagttctgtc ccaccc                                 36


<210> 109
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
aacatggtaa tgtccctcct gaagttctgt cccaccc                                37


<210> 110
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
aacatggtaa tgtccctggg gaagttctgt cccaccc                                37


<210> 111
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
aacatggtaa tgtccctttg gggaagttct gtcccaccc                              39


<210> 112
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
aacatggtaa tgtccctcct ggggatgttc tgtcccaccc                             40


<210> 113
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
aacatggtaa tgtccctcct gggatgttct gtcccaccc                              39


<210> 114
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
aacatggtaa tgtccctccg gggatgttct gtcccaccc                              39


<210> 115
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
aacatggtaa tgtccctcct gggggatgtt ctgtcccacc                             40


<210> 116
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
aacatggtaa tgtccctcct ggatgttctg tcccaccc                               38


<210> 117
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
aacatggtaa tgtccctcct gttctgtccc accc                                   34


<210> 118
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
aacatggtaa tgtccctcgg ggatgttctg tcccaccc                               38


<210> 119
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 119
aacatggtaa tgttctgtcc caccc                                             25


<210> 120
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
aacatggtaa tgtccctcct gatgttctgt cccaccc                                37


<210> 121
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 121
aacatggtaa tgtccctcct ttgttctgtc ccaccc                                 36


<210> 122
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 122
aacatgttct gtcccaccc                                                    19


<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 123
gacagaactt ccccaggngg                                                   20


<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
ttatgaactg gcacaggtgg                                                   20


<210> 125
<211> 40
<212> DNA
<213> Mus sp.

<400> 125
atggtaatgt ccctcctggg gaagttctgt cccaccctgt                             40


<210> 126
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 126
atggtaatgt ccctcctggg gatgttctgt cccaccctgt                             40


<210> 127
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 127
atggtaatgt ccctcctggg aagttctgtc ccaccctgt                              39


<210> 128
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
atggtaatgt ccctcctggg agttctgtcc caccctgt                               38


<210> 129
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 129
atggtaatgt ccctcctggg atgttctgtc ccaccctgt                              39


<210> 130
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 130
atggtaatgt ccctcctggg ttctgtccca ccctgt                                 36


<210> 131
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 131
atggtaatgt ccctcctggg ctgtcccacc ctgt                                   34


<210> 132
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 132
atggtaatgt ccctcctggg tctgtcccac cctgt                                  35


<210> 133
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 133
atggtaatgt ccctcctggg gttctgtccc accctgt                                37


<210> 134
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 134
atggtaatgt ccctcctggg tgttctgtcc caccctgt                               38


<210> 135
<211> 27
<212> DNA
<213> Mus sp.

<400> 135
acatggtaat gtccctcctg gggaagt                                           27


