                         SEQUENCE LISTING

<110>  Inscripta, Inc.
 
<120>  GENOME-WIDE RATIONALLY-DESIGNED MUTATIONS LEADING TO ENHANCED 
       LYSINE PRODUCTION IN E. COLI

<130>  INSC046PCT

<140>  PCT/US20/38345
<141>  2020-06-18

<150>  62/865,075
<151>  2019-06-21

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  292
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Phe Thr Gly Ser Ile Val Ala Ile Val Thr Pro Met Asp Glu Lys 
1               5                   10                  15      


Gly Asn Val Cys Arg Ala Ser Leu Lys Lys Leu Ile Asp Tyr His Val 
            20                  25                  30          


Ala Ser Gly Thr Ser Ala Ile Val Ser Val Gly Thr Thr Gly Glu Ser 
        35                  40                  45              


Ala Thr Leu Asn His Asp Glu His Ala Asp Val Val Met Met Thr Leu 
    50                  55                  60                  


Asp Leu Ala Asp Gly Arg Ile Pro Val Ile Ala Gly Thr Gly Ala Asn 
65                  70                  75                  80  


Ala Thr Ala Thr Ala Ile Ser Leu Thr Gln Arg Phe Asn Asp Ser Gly 
                85                  90                  95      


Ile Val Gly Cys Leu Thr Val Thr Pro Tyr Tyr Asn Arg Pro Ser Gln 
            100                 105                 110         


Glu Gly Leu Tyr Gln His Phe Lys Ala Ile Ala Glu His Thr Asp Leu 
        115                 120                 125             


Pro Gln Ile Leu Tyr Asn Val Pro Ser Arg Thr Gly Cys Asp Leu Leu 
    130                 135                 140                 


Pro Glu Thr Val Gly Arg Leu Ala Lys Val Lys Asn Ile Ile Gly Ile 
145                 150                 155                 160 


Lys Glu Ala Thr Gly Asn Leu Thr Arg Val Asn Gln Ile Lys Glu Leu 
                165                 170                 175     


Val Ser Asp Asp Phe Val Leu Leu Ser Gly Asp Asp Ala Ser Ala Leu 
            180                 185                 190         


Asp Phe Met Gln Leu Gly Gly His Gly Val Ile Ser Val Thr Ala Asn 
        195                 200                 205             


Val Ala Ala Arg Asp Met Ala Gln Met Cys Lys Leu Ala Ala Glu Gly 
    210                 215                 220                 


His Phe Ala Glu Ala Arg Val Ile Asn Gln Arg Leu Met Pro Leu His 
225                 230                 235                 240 


Asn Lys Leu Phe Val Glu Pro Asn Pro Ile Pro Val Lys Trp Ala Cys 
                245                 250                 255     


Lys Glu Leu Gly Leu Val Ala Thr Asp Thr Leu Arg Leu Pro Met Thr 
            260                 265                 270         


Pro Ile Thr Asp Ser Gly Arg Glu Thr Val Arg Ala Ala Leu Lys His 
        275                 280                 285             


Ala Gly Leu Leu 
    290         


<210>  2
<211>  121
<212>  DNA
<213>  Escherichia coli

<400>  2
ttgcttttaa tgccatacca aacgtaccat tgagacactt gtttgcacag aggatggccc       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

a                                                                      121


<210>  3
<211>  449
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ser Glu Ile Val Val Ser Lys Phe Gly Gly Thr Ser Val Ala Asp 
1               5                   10                  15      


Phe Asp Ala Met Asn Arg Ser Ala Asp Ile Val Leu Ser Asp Ala Asn 
            20                  25                  30          


Val Arg Leu Val Val Leu Ser Ala Ser Ala Gly Ile Thr Asn Leu Leu 
        35                  40                  45              


Val Ala Leu Ala Glu Gly Leu Glu Pro Gly Glu Arg Phe Glu Lys Leu 
    50                  55                  60                  


Asp Ala Ile Arg Asn Ile Gln Phe Ala Ile Leu Glu Arg Leu Arg Tyr 
65                  70                  75                  80  


Pro Asn Val Ile Arg Glu Glu Ile Glu Arg Leu Leu Glu Asn Ile Thr 
                85                  90                  95      


Val Leu Ala Glu Ala Ala Ala Leu Ala Thr Ser Pro Ala Leu Thr Asp 
            100                 105                 110         


Glu Leu Val Ser His Gly Glu Leu Met Ser Thr Leu Leu Phe Val Glu 
        115                 120                 125             


Ile Leu Arg Glu Arg Asp Val Gln Ala Gln Trp Phe Asp Val Arg Lys 
    130                 135                 140                 


Val Met Arg Thr Asn Asp Arg Phe Gly Arg Ala Glu Pro Asp Ile Ala 
145                 150                 155                 160 


Ala Leu Ala Glu Leu Ala Ala Leu Gln Leu Leu Pro Arg Leu Asn Glu 
                165                 170                 175     


Gly Leu Val Ile Thr Gln Gly Phe Ile Gly Ser Glu Asn Lys Gly Arg 
            180                 185                 190         


Thr Thr Thr Leu Gly Arg Gly Gly Ser Asp Tyr Thr Ala Ala Leu Leu 
        195                 200                 205             


Ala Glu Ala Leu His Ala Ser Arg Val Asp Ile Trp Thr Asp Val Pro 
    210                 215                 220                 


Gly Ile Tyr Thr Thr Asp Pro Arg Val Val Ser Ala Ala Lys Arg Ile 
225                 230                 235                 240 


Asp Glu Ile Ala Phe Ala Glu Ala Ala Glu Met Ala Thr Phe Gly Ala 
                245                 250                 255     


Lys Val Leu His Pro Ala Thr Leu Leu Pro Ala Val Arg Ser Asp Ile 
            260                 265                 270         


Pro Val Phe Val Gly Ser Ser Lys Asp Pro Arg Ala Gly Gly Thr Leu 
        275                 280                 285             


Val Cys Asn Lys Thr Glu Asn Pro Pro Leu Phe Arg Ala Leu Ala Leu 
    290                 295                 300                 


Arg Arg Asn Gln Thr Leu Leu Thr Leu His Ser Leu Asn Met Leu His 
305                 310                 315                 320 


Ser Arg Gly Phe Leu Ala Glu Val Phe Gly Ile Leu Ala Arg His Asn 
                325                 330                 335     


Ile Ser Pro Asp Leu Ile Thr Thr Ser Glu Val Ser Val Ala Leu Thr 
            340                 345                 350         


Leu Asp Thr Thr Gly Ser Thr Ser Thr Gly Asp Thr Leu Leu Thr Gln 
        355                 360                 365             


Ser Leu Leu Met Glu Leu Ser Ala Leu Cys Arg Val Glu Val Glu Glu 
    370                 375                 380                 


Gly Leu Ala Leu Val Ala Leu Ile Gly Asn Asp Leu Ser Lys Ala Cys 
385                 390                 395                 400 


Gly Val Gly Lys Glu Val Phe Gly Val Leu Glu Pro Phe Asn Ile Arg 
                405                 410                 415     


Met Ile Cys Tyr Gly Ala Ser Ser His Asn Leu Cys Phe Leu Val Pro 
            420                 425                 430         


Gly Glu Asp Ala Glu Gln Val Val Gln Lys Leu His Ser Asn Leu Phe 
        435                 440                 445             


Glu 
    


<210>  4
<211>  1693
<212>  DNA
<213>  Escherichia coli

<400>  4
ttatttttaa atgagaccag gtcctcattt taataacccc tggctggaga atattgcaca       60

tttacagcta gctcagtcct aggtattatg ctagctaagt aggtacgtaa ggaggtgata      120

aatggccaac atcgaaatca gacaagaaac gccaactgcg ttttatataa aagttcacga      180

cacagataat gtggcaatta ttgttaatga taatggcctg aaagcaggaa cgcgttttcc      240

ggatgggctg gaattaattg aacatattcc ccaggggcat aaagtcgcat tgctggacat      300

tccggctaat ggtgaaatta ttcgttatgg cgaagtgatt ggttacgccg tgcgtgcaat      360

cccacgcgga agctggatcg acgaatcaat ggttgtacta ccggaagcgc cgccgttaca      420

cacgctgcca ctggcaacca aagtcccgga acccttaccg ccgctggaag gatacacctt      480

tgagggctat cgcaatgccg atggcagcgt gggcaccaaa aacctgctcg gtatcaccac      540

cagcgtccac tgtgtggcag gcgtggtgga ctatgtagta aaaatcattg aacgcgatct      600

gctaccgaaa tacccgaacg tcgatggcgt ggtggggctg aatcatttgt acggttgtgg      660

cgtggcgatt aacgcaccgg cggcagttgt acctatccgt accattcaca atatttcgct      720

gaatcctaac tttggcggcg aagtaatggt gattggcctg ggttgtgaaa agttgcagcc      780

tgagcgcctg ctgactggaa cggatgatgt gcaagctatt ccagtagaaa gcgccagcat      840

tgtcagtttg caggatgaaa agcatgtcgg ttttcagtcc atggtcgagg atattttgca      900

gatcgccgaa cgccatctac aaaaactgaa tcaacggcag cgagaaacct gcccggcttc      960

agaactggtc gttggtatgc agtgcggtgg cagcgatgcg ttttctggtg taacggcaaa     1020

cccggcggtt ggctatgcgt ctgatctact ggtgcgctgc ggcgcaacgg tgatgttttc     1080

agaagtaacg gaagtgcgtg acgcgatcca tctgctgaca ccacgcgcag tgaacgaaga     1140

ggtcggcaaa cggctgctgg aggagatgga gtggtacgat aactatctca atatgggaaa     1200

aaccgaccgc agcgccaacc cttcgccggg caacaagaaa ggcggtctgg caaacgtggt     1260

agagaaggca ctcggctcca ttgctaaatc gggtaaaagc gcaattgttg aagtgctgtc     1320

gcccggtcaa cgcccgacta aacgcggatt aatttacgcc gcgacgccag ccagcgattt     1380

tgtctgtggc acgcaacagg tggcttcggg tatcacagtg caagtgttta cgaccggtcg     1440

tggtacgccg tacggcctga tggcggtacc cgtcattaaa atggcaaccc gcaccgagct     1500

ggcgaaccgc tggtttgatt taatggatat taatgcgggc accatcgcta ccggcgaaga     1560

aactattgaa gaggtgggct ggaagttgtt ccactttatt ctcgacgtcg ccagcgggaa     1620

gaagaaaacc ttctcggatc aatgggggct gcataaccag ctggcggtgt ttaacccggc     1680

accggtgacc tga                                                        1693


<210>  5
<211>  1045
<212>  DNA
<213>  Escherichia coli

<400>  5
tcgccatttt tgctatcatg cctgcataca taaacgacaa aacagtatgc agagggaaaa       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgggttcc accagaaagg ggatgctgaa cgttctgatt gccgccgtgt tgtggggaag      180

ttcaggggtc tgcgcgcaat acatcatgga gcaaagccag atgtcgtcgc agtttttgac      240

tatgacgcgt ttgatattcg ccggtttgat tctactgacg ctgtcatttg ttcatggcga      300

taaaatcttt tctattatta acaatcataa agatgccatt agcctgctga ttttttccgt      360

ggttggcgcg ctaactgtac agctcacttt tttgctaacc atcgaaaaat cgaacgcagc      420

cacggcaacg gtgctgcaat tcctctcacc gacgattatc gtcgcctggt tctcactggt      480

gcgtaaatcg cgcccgggca ttctggtttt ctgcgctatt ttgacatcgc tggtcgggac      540

ttttttattg gtgacacacg gtaatccgac gtcattatcg atctctcctg ccgcgttgtt      600

ctggggcatt gcctcggcat ttgctgctgc attctatacc acctatccct caacgctaat      660

tgcccgctat ggcacgttac cagtcgtcgg ctggagtatg ctgattggcg gtctgattct      720

gttgcctttt tatgccagac aaggaacaaa ctttgtcgtt aacggcagtt tgattctggc      780

gtttttttat ttggtggtca ttggtacgtc cctgacattt agtctgtacc tgaaaggagc      840

acaattaatt ggcggtccaa aagccagcat tttgagctgt gcagaaccat taagtagcgc      900

gctactctct ttgctgttgc tggggatcac gttcacatta ccggactggc tgggaacgct      960

gctgattctg tcatcggtga ttttgatttc aatggattcc cgtcgccgcg ccagaaaaat     1020

aaatcgtccg gcgcggcata agtga                                           1045


<210>  6
<211>  14
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Val Ser Glu Thr Lys Thr Thr Glu Ala Pro Gly Leu Arg 
1               5                   10                  


<210>  7
<211>  580
<212>  DNA
<213>  Escherichia coli

<400>  7
tatcttgcag cgataagtgc ttacagtaat ctgtaggaaa gttaactacg gatgtacatt       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatggaactg acgactcgca ctttacctgc gcggaaacat attgcgctgg tggcacacga      180

tcactgcaaa caaatgctga tgagctgggt ggaacggcat caaccgttac tggaacaaca      240

cgtactgtat gcaacaggca ctaccggtaa cttaatttcc cgcgcgaccg gcatgaacgt      300

caacgcgatg ttgagtggcc caatgggggg tgaccagcag gttggcgcat tgatctcaga      360

agggaaaatt gatgtattga ttttcttctg ggatccacta aatgccgtgc cgcacgatcc      420

tgacgtgaaa gccttgctgc gtctggcgac ggtatggaac attccggtcg ccaccaacgt      480

ggcaacggca gacttcataa tccagtcgcc gcatttcaac gacgcggtcg atattctgat      540

ccccgattat cagcgttatc tcgcggaccg tctgaagtaa                            580


<210>  8
<211>  540
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Arg Val Asn Asn Gly Leu Thr Pro Gln Glu Leu Glu Ala Tyr Gly 
1               5                   10                  15      


Ile Ser Asp Val His Asp Ile Val Tyr Asn Pro Ser Tyr Asp Leu Leu 
            20                  25                  30          


Tyr Gln Glu Glu Leu Asp Pro Ser Leu Thr Gly Tyr Glu Arg Gly Val 
        35                  40                  45              


Leu Thr Asn Leu Gly Ala Val Ala Val Asp Thr Gly Ile Phe Thr Gly 
    50                  55                  60                  


Arg Ser Pro Lys Asp Lys Tyr Ile Val Arg Asp Asp Thr Thr Arg Asp 
65                  70                  75                  80  


Thr Phe Trp Trp Ala Asp Lys Gly Lys Gly Lys Asn Asp Asn Lys Pro 
                85                  90                  95      


Leu Ser Pro Gln Thr Trp Gln His Leu Lys Gly Leu Val Thr Arg Gln 
            100                 105                 110         


Leu Ser Gly Lys Arg Leu Phe Val Val Asp Ala Phe Cys Gly Ala Asn 
        115                 120                 125             


Pro Asp Thr Arg Leu Ser Val Arg Phe Ile Thr Glu Val Ala Trp Gln 
    130                 135                 140                 


Ala His Phe Val Lys Asn Met Phe Ile Arg Pro Ser Asp Glu Glu Leu 
145                 150                 155                 160 


Ala Gly Phe Lys Pro Asp Phe Ile Val Met Asn Gly Ala Lys Cys Thr 
                165                 170                 175     


Asn Pro Gln Trp Lys Glu Gln Gly Leu Asn Ser Glu Asn Phe Val Ala 
            180                 185                 190         


Phe Asn Leu Thr Glu Arg Met Gln Leu Ile Gly Gly Thr Trp Tyr Gly 
        195                 200                 205             


Gly Glu Met Lys Lys Gly Met Phe Ser Met Met Asn Tyr Leu Leu Pro 
    210                 215                 220                 


Leu Lys Gly Ile Ala Ser Met His Cys Ser Ala Asn Val Gly Glu Lys 
225                 230                 235                 240 


Gly Asp Val Ala Val Phe Phe Gly Leu Ser Gly Thr Gly Lys Thr Thr 
                245                 250                 255     


Leu Ser Thr Asp Pro Lys Arg Arg Leu Ile Gly Asp Asp Glu His Gly 
            260                 265                 270         


Trp Asp Asp Asp Gly Val Phe Asn Phe Glu Gly Gly Cys Tyr Ala Lys 
        275                 280                 285             


Thr Ile Lys Leu Ser Lys Glu Ala Glu Pro Glu Ile Tyr Asn Ala Ile 
    290                 295                 300                 


Arg Arg Asp Ala Leu Leu Glu Asn Val Thr Val Arg Glu Asp Gly Thr 
305                 310                 315                 320 


Ile Asp Phe Asp Asp Gly Ser Lys Thr Glu Asn Thr Arg Val Ser Tyr 
                325                 330                 335     


Pro Ile Tyr His Ile Asp Asn Ile Val Lys Pro Val Ser Lys Ala Gly 
            340                 345                 350         


His Ala Thr Lys Val Ile Phe Leu Thr Ala Asp Ala Phe Gly Val Leu 
        355                 360                 365             


Pro Pro Val Ser Arg Leu Thr Ala Asp Gln Thr Gln Tyr His Phe Leu 
    370                 375                 380                 


Ser Gly Phe Thr Ala Lys Leu Ala Gly Thr Glu Arg Gly Ile Thr Glu 
385                 390                 395                 400 


Pro Thr Pro Thr Phe Ser Ala Cys Phe Gly Ala Ala Phe Leu Ser Leu 
                405                 410                 415     


His Pro Thr Gln Tyr Ala Glu Val Leu Val Lys Arg Met Gln Ala Ala 
            420                 425                 430         


Gly Ala Gln Ala Tyr Leu Val Asn Thr Gly Trp Asn Gly Thr Gly Lys 
        435                 440                 445             


Arg Ile Ser Ile Lys Asp Thr Arg Ala Ile Ile Asp Ala Ile Leu Asn 
    450                 455                 460                 


Gly Ser Leu Asp Asn Ala Glu Thr Phe Thr Leu Pro Met Phe Asn Leu 
465                 470                 475                 480 


Ala Ile Pro Thr Glu Leu Pro Gly Val Asp Thr Lys Ile Leu Asp Pro 
                485                 490                 495     


Arg Asn Thr Tyr Ala Ser Pro Glu Gln Trp Gln Glu Lys Ala Glu Thr 
            500                 505                 510         


Leu Ala Lys Leu Phe Ile Asp Asn Phe Asp Lys Tyr Thr Asp Thr Pro 
        515                 520                 525             


Ala Gly Ala Ala Leu Val Ala Ala Gly Pro Lys Leu 
    530                 535                 540 


<210>  9
<211>  1609
<212>  DNA
<213>  Escherichia coli

<400>  9
gctcgcgaat aatccgatta cggctacgct tctaatgttc cccttgaatg gagtcgaaga       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgcgtaat cccacgctgt tacaatgttt tcactggtat tacccggaag gcggtaagct      180

ctggcctgaa ctggccgagc gcgccgacgg ttttaatgat attggtatca atatggtctg      240

gttgccgccc gcctataaag gcgcatcggg cgggtattcg gtcggctacg actcctatga      300

tttatttgat ttaggcgagt ttgatcagaa aggcagcatc cctactaaat atggcgataa      360

agcacaactg ctggccgcca ttgatgctct gaaacgtaat gacattgcgg tgctgttgga      420

tgtggtagtc aaccacaaaa tgggcgcgga tgaaaaagaa gctattcgcg tgcagcgtgt      480

aaatgctgat gaccgtacgc aaattgacga agaaatcatt gagtgtgaag gctggacgcg      540

ttacaccttc cccgcccgtg ccgggcaata ctcgcagttt atctgggatt tcaaatgttt      600

tagcggtatc gaccatatcg aaaaccctga cgaagatggc atttttaaaa ttgttaacga      660

ctacaccggc gaaggctgga acgatcaggt tgatgatgaa ttaggtaatt tcgattatct      720

gatgggcgag aatatcgatt ttcgcaatca tgccgtgacg gaagagatta aatactgggc      780

gcgctgggtg atggaacaaa cgcaatgcga cggttttcgt cttgatgcgg tcaaacatat      840

tccagcctgg ttttataaag agtggatcga acacgtacag gaagttgcgc caaagccgct      900

gtttattgtg gcggagtact ggtcgcatga agttgataag ctgcaaacgt atattgatca      960

ggtggaaggc aaaaccatgc tgtttgatgc gccgctgcag atgaaattcc atgaagcatc     1020

gcgcatgggg cgcgactacg acatgacgca gattttcacg ggtacattag tggaagccga     1080

tcctttccac gccgtgacgc tcgttgccaa tcacgacacc caaccgttgc aagccctcga     1140

agcgccggtc gaaccgtggt ttaaaccgct ggcgtatgcc ttaattttgt tgcgggaaaa     1200

tggcgttcct tcggtattct atccggacct ctacggtgcg cattacgaag atgtcggtgg     1260

tgacgggcaa acctatccga tagatatgcc aataatcgaa cagcttgatg agttaattct     1320

cgcccgtcag cgtttcgccc acggtgtaca gacgttattt ttcgaccatc cgaactgcat     1380

tgcctttagc cgcagtggca ccgacgaatt tcccggctgc gtggtggtca tgtcgaacgg     1440

ggatgatggc gaaaaaacca ttcatctggg agagaattac ggcaataaaa cctggcgtga     1500

ttttctgggg aaccggcaag agagagtagt gaccgacgaa aacggcgaag caaccttctt     1560

ttgcaacggc ggcagcgtca gcgtgtgggt tatcgaagag gtgatttaa                 1609


<210>  10
<211>  14
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Arg Asn Pro Thr Leu Leu Gln Cys Phe His Trp Tyr Tyr 
1               5                   10                  


<210>  11
<211>  4
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Asn Thr Ala 
1               


<210>  12
<211>  2521
<212>  DNA
<213>  Escherichia coli

<400>  12
agaaaccgtg ttgaactctg gaaagccagt ctttagatgc gccaggatgc agaggtaatc       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgaagcta accgatgcgg ataatgccgc cgatggcatt tttttccccg cccttgagca      180

aaatatgatg ggtgcggtgt taattaacga aaatgatgaa gtgatgtttt tcaaccccgc      240

cgcagagaag ctctggggat acaaacgtga agaagtcatt ggcaataaca ttgatatgct      300

gattccgcgg gatttgcgtc ctgcgcatcc tgaatacatt cgtcacaacc gtgaaggcgg      360

taaagcgcgt gttgagggga tgagtcggga gctgcagctg gagaaaaaag acggcagtaa      420

aatctggacc cgttttgcgc tatcgaaagt gagcgccgag gggaaagttt attacctggc      480

gctggtacgg gatgccagcg tagaaatggc gcaaaaagaa cagacccgac aattgattat      540

tgccgttgac catctcgacc gaccggtgat tgtcctcgat ccggaacgcc atattgtgca      600

gtgcaatcgc gcatttaccg aaatgtttgg ttactgcatt agcgaagcca gcggtatgca      660

gcccgataca ctcctgaaca ttcctgaatt ccctgccgat aaccgcattc gtttacaaca      720

gttgctatgg aaaaccgccc gcgatcagga cgaatttctg ctgttgacgc gcaccggtga      780

aaaaatctgg attaaagcct ctatcagccc ggtttatgac gtgctcgcgc atctgcagaa      840

cctggtaatg actttctcgg atatcaccga agaacggcag attcgccagc ttgaaggcaa      900

tattctcgcc gccatgtgca gcagcccgcc atttcatgaa atgggggaaa tcatttgtcg      960

taacatcgaa tctgtactca acgaatcgca tgtttcgctg ttcgcactgc gcaacgggat     1020

gccgatacac tgggcgtcat cttcccacgg tgcagaaatt caaaatgcgc aaagctggtc     1080

agcgaccatt cgtcagcgtg atggcgcgcc tgcggggatc ctgcaaatta aaacctcgtc     1140

aggagcagaa accagcgcct ttatcgaacg cgtggcagat atcagccagc atatggccgc     1200

gctggcgctg gaacaggaaa aaagccgtca gcatattgaa caactcatcc aatttgatcc     1260

gatgaccggt ctgccaaatc gcaataacct gcacaattac ctcgatgacc tggtcgacaa     1320

agccgtctct cccgtggtgt atctcatcgg tgttgaccat attcaggatg tgattgatag     1380

ccttggctat gcgtgggccg atcaggcatt gctggaagtg gtcaatcgct ttcgtgaaaa     1440

actcaaaccg gatcagtatc tctgtcgtat cgaaggtacg cagtttgtcc tcgtgagcct     1500

cgaaaacgac gtcagtaaca ttacccaaat cgccgatgag ctacggaatg tggtcagcaa     1560

gccgataatg attgacgata aacccttccc gcttaccttg agtattggca tcagctacga     1620

cctgggtaaa aaccgcgatt acttgctctc cactgctcac aatgcaatgg attatattcg     1680

caagaatggc ggtaacggct ggcagttctt cagcccggcg atgaacgaaa tggtaaaaga     1740

gcgtttggtt ttaggcgcag cgctgaaaga agcgattagc aataaccaac tgaaactggt     1800

ttaccagccg caaatcttcg cagaaacggg tgaactgtac ggcatcgaag cccttgctcg     1860

ctggcacgat cccctgcatg gtcatgtgcc cccttcacgg tttattcctc tcgcagaaga     1920

gattggtgaa atcgaaaata ttgggcgctg ggtcatcgcg gaagcttgcc gtcagttagc     1980

agaatggcgt agccagaata ttcatatccc ggcgttatcc gtgaacttgt cggcgctgca     2040

ctttcgcagt aatcaactgc ctaatcaggt gtctgatgca atgcacgcct ggggtattga     2100

cggccaccag ctgacggtag aaatcacgga aagcatgatg atggaacacg ataccgaaat     2160

ctttaagcgc attcagatcc tgcgtgatat gggcgtgggc ttatcggtag atgattttgg     2220

tacgggcttt tccggattat cccgcttagt cagtcttccg gtaacggaaa tcaaaattga     2280

caaaagtttt gtcgatcgtt gtctgaccga aaaacgcatc cttgccttac ttgaagccat     2340

taccagcatt gggcaaagcc tcaatttaac cgtcgtggcg gaaggcgtcg aaaccaaaga     2400

gcaatttgag atgctacgca agatccactg tcgcgttatt cagggatatt tcttttcccg     2460

ccccctaccc gccgaagaaa ttccaggctg gatgagcagc gtgttaccgc tgaaaatctg     2520

a                                                                     2521


<210>  13
<211>  454
<212>  DNA
<213>  Escherichia coli

<400>  13
ggtgagttga gttcaaactg tagtacaatt ctctccagtt tgaacaggaa agaatatgct       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgaaccct tatatttatc ttggtggtgc aatacttgca gaggtcattg gtacaacctt      180

aatgaagttt tcagaaggtt ttacacggtt atggccatct gttggtacaa ttatttgtta      240

ttgtgcatca ttctggttat tagctcagac gctggcttat attcctacag ggattgctta      300

tgctatctgg tcaggagtcg gtattgtcct gattagctta ctgtcatggg gatttttcgg      360

ccaacggctg gacctgccag ccattatagg catgatgttg atttgtgccg gtgtgttgat      420

tattaattta ttgtcacgaa gcacaccaca ttaa                                  454


<210>  14
<211>  970
<212>  DNA
<213>  Escherichia coli

<400>  14
atgcagcggc tggggatctc ggttcgcgag gtgttgtaat ctgcttttgc aggagtatgc       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgagaaac aaactctctt tcgacttgca gttgagcgcc agaaaagcgg caatcgctga      180

acggattgcc gcccataaaa ttgcccgcag taaagtgtcg gtctttttaa tggcgatgtc      240

cgctggcgtg tttatggcga tcggatttac tttttacctt tccgttatcg ccgatgcccc      300

gtcttcacag gcattaaccc atctggtggg cggcctttgc tttacactcg gctttatttt      360

gctggcggtt tgcggcacca gcctgttcac ctcgtcggta atgacggtga tggcaaaaag      420

tcggggcgtt attagttggc gaacttggct gattaacgca cttctggtgg cctgcggtaa      480

tctggcaggt attgcctgtt tcagtttgtt aatctggttt tccgggctgg tgatgagtga      540

aaacgcgatg tggggagtcg cggttttaca ctgcgccgag ggcaaaatgc atcatacatt      600

tactgaatct gtcagcctcg gcattatgtg caatctgatg gtttgcctgg cgctgtggat      660

gagttattgc gggcgttcgt tatgcgacaa aatcgtcgcc atgattttgc ccatcaccct      720

gtttgtcgcc agtggctttg agcactgtat cgccaatttg tttgtgattc cgttcgccat      780

tgccattcgc catttcgccc ctcccccctt ctggcagctg gcgcacagta gcgcagacaa      840

ttttccggca ctgacggtca gccattttat taccgccaat ctgctcccgg tgatgctggg      900

taatattatc ggcggtgcgg tgctggtgag tatgtgttat cgggctattt atttacgtca      960

ggaaccctga                                                             970


<210>  15
<211>  2794
<212>  DNA
<213>  Escherichia coli

<400>  15
atgaagccgg cgaatgccgg cttttttaat gcgataattt aatcttatgg gtggcgcaca       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgaatacc cttccagaac agtacgcaaa caccgctctc cccaccctgc ccggtcaacc      180

gcaaaatcca tgcgtctggc cccgtgatga attaaccgtc ggtgggataa aagcccatat      240

cgatactttc cagcgttggc tgggtgatgc ctttgacaat gggatctctg cagaacagtt      300

gattgaggcg cgcaccgagt ttatcgacca gctcctgcaa cgattatgga ttgaagcggg      360

attcagccag attgccgacc tggcattggt cgccgtcggt ggctacggtc gtggcgagct      420

gcatccactt tcagacgtcg atttactgat tttaagccgt aaaaagctcc cggacgatca      480

ggcgcaaaaa gtgggcgagc tgttaacgct gctctgggat gtaaagctgg aagtcggtca      540

tagcgtgcgc acgcttgaag agtgcatgct ggaagggtta tcggatttaa ccgtcgccac      600

caatttaatc gaatcccgct tattaattgg cgatgttgcg ctgttcctcg aactgcaaaa      660

acatattttc agcgaaggat tctggccttc cgacaagttc tacgcggcga aagttgaaga      720

acagaaccag cgccatcagc gttaccatgg caccagctac aaccttgaac cagacatcaa      780

aagcagccct ggcggcttgc gcgatatcca cactctgcaa tgggtggccc gccgtcattt      840

tggcgcaaca tcgctggatg aaatggtcgg gtttggcttc ttaacctcag cggagcgggc      900

ggaattaaac gaatgtctgc atatattgtg gcgtattcgc tttgccctgc atctggtcgt      960

cagccgttac gataatcgcc tgttattcga tcgccagctt agcgtcgccc agcgtctgaa     1020

ttacagtggt gaaggtaacg aaccggtcga gcggatgatg aaggattact tccgcgttac     1080

acgccgcgtc agtgaactca accagatgct gctgcaactg ttcgatgaag ccatcctcgc     1140

ccttcccgcc gacgaaaaac cacgtccaat cgacgatgag tttcagctac gcggtacgct     1200

aatcgacctg cgtgatgaaa cactatttat gcgccagccg gaagccatct tgcgtatgtt     1260

ctacaccatg gtgcacaaca gtgcgatcac cggcatttac tccaccacgc tgcgccagtt     1320

acgccatgcc cgtcgccatc tgcaacaacc gctgtgtaat attccggaag cacgaaaact     1380

gtttttgagc attctgcgtc accccggagc ggtgcggcgc gggctattgc caatgcatcg     1440

ccatagcgtg ctcggcgcgt atatgccgca atggtcgcat atcgtcgggc agatgcagtt     1500

tgatctgttc cacgcctaca cggtggatga acatactatc cgcgtgatgc tgaaactgga     1560

gagttttgcc agtgaagaaa cgcgccagcg ccatccgttg tgtgtggacg tctggccgcg     1620

cctgccgtca actgagctga ttttcatcgc cgcgctgttt cacgatatcg ccaaaggacg     1680

cggcggcgac cactccattc tcggtgctca ggatgtagtg cattttgccg aactccacgg     1740

gctgaactca cgcgaaacac agctggtcgc ctggctggtt cgccagcacc tgttgatgtc     1800

ggtgaccgcc caacgccgcg atattcagga cccggaagtc atcaagcagt ttgccgaaga     1860

agtgcaaacg gaaaatcgtc tgcgctatct ggtatgcctg actgtggctg acatttgcgc     1920

caccaacgaa acgctgtgga atagctggaa gcaaagtctg ttgcgtgagc tctactttgc     1980

caccgaaaag cagctacgac gcggaatgca aaacacgccg gatatgcgcg aacgggttcg     2040

ccatcaccaa ctccaggcac tggcactact gcgcatggat aacatcgacg aagaggcgct     2100

gcaccaaatt tggtcacgct gtcgtgctaa ctattttgtc cgccatagcc caaatcaact     2160

ggcctggcat gcccgccatt tattacagca tgatttaagc aaaccgctgg tattgcttag     2220

cccgcaggct acgcgtggag gcaccgagat ttttatctgg agcccggacc gcccttatct     2280

gtttgccgcc gtctgtgccg aattagaccg ccgcaattta agtgttcacg acgcacaaat     2340

tttcaccact cgcgacggta tggcgatgga tacctttatc gtgctggaac ccgatggcaa     2400

cccgctgtcc gcagatcgtc atgaggttat tcggtttggt ctggagcaag tactgacgca     2460

aagtagctgg cagccaccgc agccccgtcg ccaacccgcc aaattacgcc attttactgt     2520

tgaaaccgaa gtaacgtttt tgccgaccca taccgaccgc aaatcgttcc tcgaactgat     2580

cgccctcgac caacctggac tgctggcgcg agtcgggaaa atttttgccg atctgggaat     2640

ttcgcttcat ggtgcccgaa ttacaaccat tggcgagcga gtagaagatt tattcataat     2700

tgccaccgct gaccggcgtg cgcttaataa cgagttgcag caggaagtgc atcagcggtt     2760

gacagaggcc ctcaatccaa acgataaagg gtga                                 2794


<210>  16
<211>  14
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Lys Pro Leu Ser Ser Pro Leu Gln Gln Tyr Trp Gln Thr 
1               5                   10                  


<210>  17
<211>  538
<212>  DNA
<213>  Escherichia coli

<400>  17
ctcggtttga gttaatcgcc aattaaaaag gttaatgaca tgcgagagac agtcgaaatt       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgcgttat cccgtcactc ttacacccgc gccggaaggc ggttatatgg tttcttttgt      180

ggatatccct gaagcgttga cccagggcga aactgtcgct gaagcgatgg aagcggcaaa      240

agatgcttta ctgaccgcat ttgattttta ttttgaagat aacgagctta tccctttacc      300

ttcgccatta aatagtcacg atcactttat tgaagtacct ttgagcgtcg cctctaaggt      360

attgctgtta aatgcttttt tacagtcaga aatcactcag caagagttag ccaggcgaat      420

tggcaaacct aaacaggaga ttactcgcct atttaacttg catcatgcga caaaaatcga      480

cgccgtccag ctcgcggcaa aggcgcttgg caaagagtta tcgctggtga tggtttaa        538


<210>  18
<211>  2401
<212>  DNA
<213>  Escherichia coli

<400>  18
tgggcagggg ctgttgccca cacactttat ttgtgaacgt tacgtgaaag gaacaaccaa       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatggatgac cagttaaaac aaagtgcact tgatttccat gaatttccag ttccagggaa      180

aatccaggtt tctccaacca agcctctggc aacacagcgc gatctggcgc tggcctactc      240

accaggcgtt gccgcacctt gtcttgaaat cgaaaaagac ccgttaaaag cctacaaata      300

taccgcccga ggtaacctgg tggcggtgat ctctaacggt acggcggtgc tggggttagg      360

caacattggc gcgctggcag gcaaaccggt gatggaaggc aagggcgttc tgtttaagaa      420

attcgccggg attgatgtat ttgacattga agttgacgaa ctcgacccgg acaaatttat      480

tgaagttgtc gccgcgctcg aaccaacctt cggcggcatc aacctcgaag acattaaagc      540

gccagaatgt ttctatattg aacagaaact gcgcgagcgg atgaatattc cggtattcca      600

cgacgatcag cacggcacgg caattatcag cactgccgcc atcctcaacg gcttgcgcgt      660

ggtggagaaa aacatctccg acgtgcggat ggtggtttcc ggcgcgggtg ccgcagcaat      720

cgcctgtatg aacctgctgg tagcgctggg tctgcaaaaa cataacatcg tggtttgcga      780

ttcaaaaggc gttatctatc agggccgtga gccaaacatg gcggaaacca aagccgcata      840

tgcggtggtg gatgacggca aacgtaccct cgatgatgtg attgaaggcg cggatatttt      900

cctgggctgt tccggcccga aagtgctgac ccaggaaatg gtgaagaaaa tggctcgtgc      960

gccaatgatc ctggcgctgg cgaacccgga accggaaatt ctgccgccgc tggcgaaaga     1020

agtgcgtccg gatgccatca tttgcaccgg tcgttctgac tatccgaacc aggtgaacaa     1080

cgtcctgtgc ttcccgttca tcttccgtgg cgcgctggac gttggcgcaa ccgccatcaa     1140

cgaagagatg aaactggcgg cggtacgtgc gattgcagaa ctcgcccatg cggaacagag     1200

cgaagtggtg gcttcagcgt atggcgatca ggatctgagc tttggtccgg aatacatcat     1260

tccaaaaccg tttgatccgc gcttgatcgt taagatcgct cctgcggtcg ctaaagccgc     1320

gatggagtcg ggcgtggcga ctcgtccgat tgctgatttc gacgtctaca tcgacaagct     1380

gactgagttc gtttacaaaa ccaacctgtt tatgaagccg attttctccc aggctcgcaa     1440

agcgccgaag cgcgttgttc tgccggaagg ggaagaggcg cgcgttctgc atgccactca     1500

ggaactggta acgctgggac tggcgaaacc gatccttatc ggtcgtccga acgtgatcga     1560

aatgcgcatt cagaaactgg gcttgcagat caaagcgggc gttgattttg agatcgtcaa     1620

taacgaatcc gatccgcgct ttaaagagta ctggaccgaa tacttccaga tcatgaagcg     1680

tcgcggcgtc actcaggaac aggcgcagcg ggcgctgatc agtaacccga cagtgatcgg     1740

cgcgatcatg gttcagcgtg gggaagccga tgcaatgatt tgcggtacgg tgggtgatta     1800

tcatgaacat tttagcgtgg tgaaaaatgt ctttggttat cgcgatggcg ttcacaccgc     1860

aggtgccatg aacgcgctgc tgctgccgag tggtaacacc tttattgccg atacatatgt     1920

taatgatgaa ccggatgcag aagagctggc ggagatcacc ttgatggcgg cagaaactgt     1980

ccgtcgtttt ggtattgagc cgcgcgttgc tttgttgtcg cactccaact ttggttcttc     2040

tgactgcccg tcgtcgagca aaatgcgtca ggcgctggaa ctggtcaggg aacgtgcacc     2100

agaactgatg attgatggtg aaatgcacgg cgatgcagcg ctggtggaag cgattcgcaa     2160

cgaccgtatg ccggacagct ctttgaaagg ttccgccaat attctggtga tgccgaacat     2220

ggaagctgcc cgcattagtt acaacttact gcgtgtttcc agctcggaag gtgtgactgt     2280

cggcccggtg ctgatgggtg tggcgaaacc ggttcacgtg ttaacgccga tcgcatcggt     2340

gcgtcgtatc gtcaacatgg tggcgctggc cgtggtagaa gcgcaaaccc aaccgctgta     2400

a                                                                     2401


<210>  19
<211>  127
<212>  PRT
<213>  Escherichia coli

<400>  19

Met Ser Arg Arg Asn Thr Asp Ala Ile Thr Ile His Ser Ile Leu Asp 
1               5                   10                  15      


Trp Ile Glu Asp Asn Leu Glu Ser Pro Leu Ser Leu Glu Lys Val Ser 
            20                  25                  30          


Glu Arg Ser Gly Tyr Ser Lys Trp His Leu Gln Arg Met Phe Lys Lys 
        35                  40                  45              


Glu Thr Gly His Ser Leu Gly Gln Tyr Ile Arg Ser Arg Lys Met Thr 
    50                  55                  60                  


Glu Ile Ala Gln Lys Leu Lys Glu Ser Asn Glu Pro Ile Leu Tyr Leu 
65                  70                  75                  80  


Ala Glu Arg Tyr Gly Phe Glu Ser Gln Gln Thr Leu Thr Arg Thr Phe 
                85                  90                  95      


Lys Asn Tyr Phe Asp Val Pro Pro His Lys Asp Arg Met Thr Asn Met 
            100                 105                 110         


Gln Gly Glu Ser Arg Phe Leu His Pro Leu Asn His Tyr Asn Ser 
        115                 120                 125         


<210>  20
<211>  810
<212>  PRT
<213>  Escherichia coli

<400>  20

Met Ser Val Ile Ala Gln Ala Gly Ala Lys Gly Arg Gln Leu His Lys 
1               5                   10                  15      


Phe Gly Gly Ser Ser Leu Ala Asp Val Lys Cys Tyr Leu Arg Val Ala 
            20                  25                  30          


Gly Ile Met Ala Glu Tyr Ser Gln Pro Asp Asp Met Met Val Val Ser 
        35                  40                  45              


Ala Ala Gly Ser Thr Thr Asn Gln Leu Ile Asn Trp Leu Lys Leu Ser 
    50                  55                  60                  


Gln Thr Asp Arg Leu Ser Ala His Gln Val Gln Gln Thr Leu Arg Arg 
65                  70                  75                  80  


Tyr Gln Cys Asp Leu Ile Ser Gly Leu Leu Pro Ala Glu Glu Ala Asp 
                85                  90                  95      


Ser Leu Ile Ser Ala Phe Val Ser Asp Leu Glu Arg Leu Ala Ala Leu 
            100                 105                 110         


Leu Asp Ser Gly Ile Asn Asp Ala Val Tyr Ala Glu Val Val Gly His 
        115                 120                 125             


Gly Glu Val Trp Ser Ala Arg Leu Met Ser Ala Val Leu Asn Gln Gln 
    130                 135                 140                 


Gly Leu Pro Ala Ala Trp Leu Asp Ala Arg Glu Phe Leu Arg Ala Glu 
145                 150                 155                 160 


Arg Ala Ala Gln Pro Gln Val Asp Glu Gly Leu Ser Tyr Pro Leu Leu 
                165                 170                 175     


Gln Gln Leu Leu Val Gln His Pro Gly Lys Arg Leu Val Val Thr Gly 
            180                 185                 190         


Phe Ile Ser Arg Asn Asn Ala Gly Glu Thr Val Leu Leu Gly Arg Asn 
        195                 200                 205             


Gly Ser Asp Tyr Ser Ala Thr Gln Ile Gly Ala Leu Ala Gly Val Ser 
    210                 215                 220                 


Arg Val Thr Ile Trp Ser Asp Val Ala Gly Val Tyr Ser Ala Asp Pro 
225                 230                 235                 240 


Glu Lys Val Lys Asp Ala Cys Leu Leu Pro Leu Leu Arg Leu Asp Glu 
                245                 250                 255     


Ala Ser Glu Leu Ala Arg Leu Ala Ala Pro Val Leu His Ala Arg Thr 
            260                 265                 270         


Leu Gln Pro Val Ser Gly Ser Glu Ile Asp Leu Gln Leu Arg Cys Ser 
        275                 280                 285             


Tyr Thr Pro Asp Gln Gly Ser Thr Arg Ile Glu Arg Val Leu Ala Ser 
    290                 295                 300                 


Gly Thr Gly Ala Arg Ile Val Thr Ser His Asp Asp Val Cys Leu Ile 
305                 310                 315                 320 


Glu Phe Gln Val Pro Ala Ser Gln Asp Phe Lys Leu Ala His Lys Glu 
                325                 330                 335     


Ile Asp Gln Ile Leu Lys Arg Ala Gln Val Arg Pro Leu Ala Val Gly 
            340                 345                 350         


Val His Asn Asp Arg Gln Leu Leu Gln Phe Cys Tyr Thr Ser Glu Val 
        355                 360                 365             


Ala Asp Ser Ala Leu Lys Ile Leu Asp Glu Ala Gly Leu Pro Gly Glu 
    370                 375                 380                 


Leu Arg Leu Arg Gln Gly Leu Ala Leu Val Ala Met Val Gly Ala Gly 
385                 390                 395                 400 


Val Thr Arg Asn Pro Leu His Cys His Arg Phe Trp Gln Gln Leu Lys 
                405                 410                 415     


Gly Gln Pro Val Glu Phe Thr Trp Gln Ser Asp Asp Gly Ile Ser Leu 
            420                 425                 430         


Val Ala Val Leu Arg Thr Gly Pro Thr Glu Ser Leu Ile Gln Gly Leu 
        435                 440                 445             


His Gln Ser Val Phe Arg Ala Glu Lys Arg Ile Gly Leu Val Leu Phe 
    450                 455                 460                 


Gly Lys Gly Asn Ile Gly Ser Arg Trp Leu Glu Leu Phe Ala Arg Glu 
465                 470                 475                 480 


Gln Ser Thr Leu Ser Ala Arg Thr Gly Phe Glu Phe Val Leu Ala Gly 
                485                 490                 495     


Val Val Asp Ser Arg Arg Ser Leu Leu Ser Tyr Asp Gly Leu Asp Ala 
            500                 505                 510         


Ser Arg Ala Leu Ala Phe Phe Asn Asp Glu Ala Val Glu Gln Asp Glu 
        515                 520                 525             


Glu Ser Leu Phe Leu Trp Met Arg Ala His Pro Tyr Asp Asp Leu Val 
    530                 535                 540                 


Val Leu Asp Val Thr Ala Ser Gln Gln Leu Ala Asp Gln Tyr Leu Asp 
545                 550                 555                 560 


Phe Ala Ser His Gly Phe His Val Ile Ser Ala Asn Lys Leu Ala Gly 
                565                 570                 575     


Ala Ser Asp Ser Asn Lys Tyr Arg Gln Ile His Asp Ala Phe Glu Lys 
            580                 585                 590         


Thr Gly Arg His Trp Leu Tyr Asn Ala Thr Val Gly Ala Gly Leu Pro 
        595                 600                 605             


Ile Asn His Thr Val Arg Asp Leu Ile Asp Ser Gly Asp Thr Ile Leu 
    610                 615                 620                 


Ser Ile Ser Gly Ile Phe Ser Gly Thr Leu Ser Trp Leu Phe Leu Gln 
625                 630                 635                 640 


Phe Asp Gly Ser Val Pro Phe Thr Glu Leu Val Asp Gln Ala Trp Gln 
                645                 650                 655     


Gln Gly Leu Thr Glu Pro Asp Pro Arg Asp Asp Leu Ser Gly Lys Asp 
            660                 665                 670         


Val Met Arg Lys Leu Val Ile Leu Ala Arg Glu Ala Gly Tyr Asn Ile 
        675                 680                 685             


Glu Pro Asp Gln Val Arg Val Glu Ser Leu Val Pro Ala His Cys Glu 
    690                 695                 700                 


Gly Gly Ser Ile Asp His Phe Phe Glu Asn Gly Asp Glu Leu Asn Glu 
705                 710                 715                 720 


Gln Met Val Gln Arg Leu Glu Ala Ala Arg Glu Met Gly Leu Val Leu 
                725                 730                 735     


Arg Tyr Val Ala Arg Phe Asp Ala Asn Gly Lys Ala Arg Val Gly Val 
            740                 745                 750         


Glu Ala Val Arg Glu Asp His Pro Leu Ala Ser Leu Leu Pro Cys Asp 
        755                 760                 765             


Asn Val Phe Ala Ile Glu Ser Arg Trp Tyr Arg Asp Asn Pro Leu Val 
    770                 775                 780                 


Ile Arg Gly Pro Gly Ala Gly Arg Asp Val Thr Ala Gly Ala Ile Gln 
785                 790                 795                 800 


Ser Asp Ile Asn Arg Leu Ala Gln Leu Leu 
                805                 810 


<210>  21
<211>  4
<212>  PRT
<213>  Escherichia coli

<400>  21

Met Pro Glu Gln 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Escherichia coli

<400>  22

Met Asp Val Met 
1               


<210>  23
<211>  540
<212>  PRT
<213>  Escherichia coli

<400>  23

Met Arg Val Asn Asn Gly Leu Thr Pro Gln Glu Leu Glu Ala Tyr Gly 
1               5                   10                  15      


Ile Ser Asp Val His Asp Ile Val Tyr Asn Pro Ser Tyr Asp Leu Leu 
            20                  25                  30          


Tyr Gln Glu Glu Leu Asp Pro Ser Leu Thr Gly Tyr Glu Arg Gly Val 
        35                  40                  45              


Leu Thr Asn Leu Gly Ala Val Ala Val Asp Thr Gly Ile Phe Thr Gly 
    50                  55                  60                  


Arg Ser Pro Lys Asp Lys Tyr Ile Val Arg Asp Asp Thr Thr Arg Asp 
65                  70                  75                  80  


Thr Phe Trp Trp Ala Asp Lys Gly Lys Gly Lys Asn Asp Asn Lys Pro 
                85                  90                  95      


Leu Ser Pro Glu Thr Trp Gln His Leu Lys Gly Leu Val Thr Arg Gln 
            100                 105                 110         


Leu Ser Gly Lys Arg Leu Phe Val Val Asp Ala Phe Cys Gly Ala Asn 
        115                 120                 125             


Pro Asp Thr Arg Leu Ser Val Arg Phe Ile Thr Glu Val Ala Trp Gln 
    130                 135                 140                 


Ala His Phe Val Lys Asn Met Phe Ile Arg Pro Ser Asp Glu Glu Leu 
145                 150                 155                 160 


Ala Gly Phe Lys Pro Asp Phe Ile Val Met Asn Gly Ala Lys Cys Thr 
                165                 170                 175     


Asn Pro Gln Trp Lys Glu Gln Gly Leu Asn Ser Glu Asn Phe Val Ala 
            180                 185                 190         


Phe Asn Leu Thr Glu Arg Met Gln Leu Ile Gly Gly Thr Trp Tyr Gly 
        195                 200                 205             


Gly Glu Met Lys Lys Gly Met Phe Ser Met Met Asn Tyr Leu Leu Pro 
    210                 215                 220                 


Leu Lys Gly Ile Ala Ser Met Gly Cys Ser Ala Asn Val Gly Glu Lys 
225                 230                 235                 240 


Gly Asp Val Ala Val Phe Phe Gly Leu Ser Gly Thr Gly Lys Thr Thr 
                245                 250                 255     


Leu Ser Thr Asp Pro Lys Arg Arg Leu Ile Gly Asp Asp Glu His Gly 
            260                 265                 270         


Trp Asp Asp Asp Gly Val Phe Asn Phe Glu Gly Gly Cys Tyr Ala Lys 
        275                 280                 285             


Thr Ile Lys Leu Ser Lys Glu Ala Glu Pro Glu Ile Tyr Asn Ala Ile 
    290                 295                 300                 


Arg Arg Asp Ala Leu Leu Glu Asn Val Thr Val Arg Glu Asp Gly Thr 
305                 310                 315                 320 


Ile Asp Phe Asp Asp Gly Ser Lys Thr Glu Asn Thr Arg Val Ser Tyr 
                325                 330                 335     


Pro Ile Tyr His Ile Asp Asn Ile Val Lys Pro Val Ser Lys Ala Gly 
            340                 345                 350         


His Ala Thr Lys Val Ile Phe Leu Thr Ala Asp Ala Phe Gly Val Leu 
        355                 360                 365             


Pro Pro Val Ser Arg Leu Thr Ala Asp Gln Thr Gln Tyr His Phe Leu 
    370                 375                 380                 


Ser Gly Phe Thr Ala Lys Leu Ala Gly Thr Glu Arg Gly Ile Thr Glu 
385                 390                 395                 400 


Pro Thr Pro Thr Phe Ser Ala Cys Phe Gly Ala Ala Phe Leu Ser Leu 
                405                 410                 415     


His Pro Thr Gln Tyr Ala Glu Val Leu Val Lys Arg Met Gln Ala Ala 
            420                 425                 430         


Gly Ala Gln Ala Tyr Leu Val Asn Thr Gly Trp Asn Gly Thr Gly Lys 
        435                 440                 445             


Arg Ile Ser Ile Lys Asp Thr Arg Ala Ile Ile Asp Ala Ile Leu Asn 
    450                 455                 460                 


Gly Ser Leu Asp Asn Ala Glu Thr Phe Thr Leu Pro Met Phe Asn Leu 
465                 470                 475                 480 


Ala Ile Pro Thr Glu Leu Pro Gly Val Asp Thr Lys Ile Leu Asp Pro 
                485                 490                 495     


Arg Asn Thr Tyr Ala Ser Pro Glu Gln Trp Gln Glu Lys Ala Glu Thr 
            500                 505                 510         


Leu Ala Lys Leu Phe Ile Asp Asn Phe Asp Lys Tyr Thr Asp Thr Pro 
        515                 520                 525             


Ala Gly Ala Ala Leu Val Ala Ala Gly Pro Lys Leu 
    530                 535                 540 


<210>  24
<211>  811
<212>  DNA
<213>  Escherichia coli

<400>  24
tctgacgcat aatgacgtcg cattaatgat cgcaacctat ttattacaac agggcaaatc       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatggcgaga cgtattctgg tcgtagaaga tgaagctcca attcgcgaaa tggtctgctt      180

cgtgctcgaa caaaatggct ttcagccggt cgaagcggaa gattatgaca gtgctgtgaa      240

tcaactgaat gaaccctggc cggatttaat tctcctcgac tggatgttac ctggcggctc      300

cggtatccag ttcatcaaac acctcaagcg cgagtcgatg acccgggata ttccagtggt      360

gatgttgacc gccagagggg aagaagaaga tcgcgtgcgc ggccttgaaa ccggcgcgga      420

tgactatatc accaagccgt tttcgccgaa ggagctggtg gcgcgaatca aagcggtaat      480

gcgccgtatt tcgccaatgg cggtggaaga ggtgattgag atgcagggat taagtctcga      540

cccgacatct caccgagtga tggcgggcga agagccgctg gagatggggc cgacagaatt      600

taaactgctg cactttttta tgacgcatcc tgagcgcgtg tacagccgcg agcagctgtt      660

aaaccacgtc tggggaacta acgtgtatgt ggaagaccgc acggtcgatg tccacattcg      720

tcgcctgcgt aaagcactgg agcccggcgg gcatgaccgc atggtgcaga ccgtgcgcgg      780

tacaggatat cgtttttcaa cccgctttta a                                     811


<210>  25
<211>  1159
<212>  DNA
<213>  Escherichia coli

<400>  25
ctgttagaat tgcgccgaat tttatttttc taccgcaagt aacgcgtggg gacccaagca       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

agtgaccgat aaaacctctc ttagctacaa agatgccggt gttgatattg acgcgggtaa      180

tgctctggtt ggaagaatca aaggcgtagt gaagaaaacg cgtcgtccgg aagtgatggg      240

cggtctgggc ggcttcggtg cgctgtgtgc attgccgcaa aaatatcgtg aacccgtgct      300

ggtttctggc actgacggcg taggtaccaa gctgcgtctg gcaatggact taaaacgtca      360

cgacaccatt ggtattgatc tggtcgccat gtgcgttaat gacctggtgg tgcaaggtgc      420

agagccgctg tttttcctcg actattacgc aaccggaaaa ctggatgttg ataccgcttc      480

agcggtgatc agcggcattg cggaaggttg tctgcaatca ggctgttcac tggtgggtgg      540

cgaaacggca gaaatgccgg ggatgtatca cggtgaggat tacgatgtcg cgggtttctg      600

cgttggcgtg gtagaaaaat cagaaatcat cgacggctct aaagtcagcg acggcgatgt      660

gctgattgca ctcggttcca gcggtccaca ctcgaacggc tattcgctgg tgcgcaaaat      720

tcttgaagtc agcggttgtg atccgcaaac caccgaactt gatggtaagc cattagccga      780

tcatctgctg gcaccgaccc gcatttacgt gaagtcagtg ctggagttga ttgaaaaggt      840

cgatgtgcat gccattgcgc acctgaccgg cggcggcttc tgggaaaaca ttccgcgcgt      900

attgccagat aatactcagg cagtgattga tgaatcttcc tggcagtggc cggaagtgtt      960

caactggctg caaacggcag gtaacgttga gcaccatgaa atgtatcgca ccttcaactg     1020

cggcgtcggg atgattattg ccctgcctgc tccggaagtg gacaaagccc tcgccctgct     1080

caatgccaac ggtgaaaacg cgtggaaaat cggtatcatc aaagcctctg attccgaaca     1140

acgcgtggtt atcgaataa                                                  1159


<210>  26
<211>  4
<212>  PRT
<213>  Escherichia coli

<400>  26

Met Asn Ser Leu 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Escherichia coli

<400>  27

Met Asn Thr Asn 
1               


<210>  28
<211>  703
<212>  DNA
<213>  Escherichia coli

<400>  28
ctgttgtcgc ctgctctgga ttaacggata ataggcggct tttttatttc aggccgaaaa       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgactgac tacctgttac tgtttgtcgg aactgtactg gtcaataact ttgtactggt      180

caagtttctc ggtctctgtc cgtttatggg ggtttccaaa aaactggaaa ccgcgatggg      240

catggggctg gcaacaacgt ttgtgatgac gctggcgtct atttgcgcct ggcttatcga      300

tacgtggatt ttgatcccac ttaatctgat ttacctgcgc accctggcat ttattctggt      360

gattgctgtg gtcgtgcagt tcaccgagat ggtggtgcgc aaaaccagcc cggtgcttta      420

ccgtctgctg gggatttttt tgccgcttat caccaccaac tgtgcagtgc tcggcgtggc      480

gttgctgaat atcaatctcg ggcacaattt cttgcagtcg gcgctgtacg gtttttccgc      540

cgctgtcggt ttctcgctgg tgatggtgct cttcgccgcc atccgcgaac gccttgctgt      600

ggctgatgtc ccggcacctt ttcgcggtaa tgccattgcg ttaattaccg caggtcttat      660

gtctctggcc tttatgggct ttagtggttt ggtgaagttg taa                        703


<210>  29
<211>  1480
<212>  DNA
<213>  Escherichia coli

<400>  29
aaagatgcgg caagtgaatt tgccgcaatt gctacctttt tagcaaatcc gaggcaccta       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatggaacaa tatgatcaaa ttggcgcaag actggaccgc ttgcctttgg cccggtttca      180

ttatcgtata tttggtatta taagctttag tctgttatta acagggtttt tgagttactc      240

cggtaatgtc gtcttagcaa agctggtaag caatggatgg tcaaataatt tcctcaatgc      300

cgcctttacc tcggcattaa tgtttggtta tttcatcggc tcacttactg gtgggtttat      360

tggtgactac tttgggcggc gcagggcgtt tcgcataaat cttctcatcg tcggtattgc      420

tgcaacaggg gccgcttttg tccctgatat gtactggctc atcttctttc gcttcctgat      480

gggaacagga atgggggcgc tgattatggt tggctatgcc tcatttacgg agtttatccc      540

cgcgacggtg cgtggaaaat ggtccgcgcg gctctcattt gttggtaact ggtcgcccat      600

gctgtctgcg gcgataggcg tggtggttat cgcttttttt agttggcgaa taatgtttct      660

gctgggtggt attggcatac tgttagcctg gtttctctca ggtaaatact ttatcgagtc      720

gccacgatgg ctggcaggga aagggcaaat cgcaggtgca gaatgccaac ttcgtgaagt      780

agagcagcaa attgaaagag agaagagtat tcgtttaccc ccgcttactt cgtatcagag      840

caacagcaag gttaaagtaa tcaagggtac tttctggctc ctgtttaaag gtgaaatgtt      900

acgacgtaca ttagtcgcga ttactgtttt aattgcaatg aacatttcgc tttataccat      960

caccgtatgg ataccgacca tatttgttaa ctccggcatt gatgtcgata aatcaatatt     1020

aatgaccgct gttattatga ttggcgctcc ggtaggaata tttattgcgg cattaattat     1080

tgatcatttt cctcgtcggt tatttggctc caccttactt attattattg ccgtgttagg     1140

ctatatctat tcaattcaga ctacagagtg ggcgatttta atctatggac tggtgatgat     1200

cttcttttta tacatgtatg tttgcttcgc gtcggcggtt tatatcccgg agctttggcc     1260

aacgcattta cgcctgcgcg gttcgggttt cgttaatgcc gtcggacgga tcgtcgcagt     1320

cttcacgccc tatggcgttg cggcattatt aacacattat gggtcgatca cggtgtttat     1380

ggtacttggt gttatgttat tgctctgtgc gctggttctc tccatttttg gcatcgaaac     1440

gcggaaggtg tcgttggaag agatttctga ggtgaattaa                           1480


<210>  30
<211>  1045
<212>  DNA
<213>  Escherichia coli

<400>  30
tcgccatttt tgctatcatg cctgcataca taaacgacaa aacagtatgc agagggaaaa       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgggttcc accagaaagg ggatgctgaa cgttctgatt gccgccgtgt tgtggggaag      180

ttcaggggtc tgcgcgcaat acatcatgga gcaaagccag atgtcgtcgc agtttttgac      240

tatgacgcgt ttgatattcg ccggtttgat tctactgacg ctgtcatttg ttcatggcga      300

taaaatcttt tctattatta acaatcataa agatgccatt agcctgctga ttttttccgt      360

ggttggcgcg ctaactgtac agctcacttt tttgctaacc atcgaaaaat cgaacgcagc      420

cacggcaacg gtgctgcaat tcctctcacc gacgattatc gtcgcctggt tctcactggt      480

gcgtaaatcg cgcccgggca ttctggtttt ctgcgctatt ttgacatcgc tggtcgggac      540

ttttttattg gtgacacacg gtaatccgac gtcattatcg atctctcctg ccgcgttgtt      600

ctggggcatt gcctcggcat ttgctgctgc attctatacc acctatccct caacgctaat      660

tgcccgctat ggcacgttac cagtcgtcgg ctggagtatg ctgattggcg gtctgattct      720

gttgcctttt tatgccagac aaggaacaaa ctttgtcgtt aacggcagtt tgattctggc      780

gtttttttat ttggtggtca ttggtacgtc cctgacattt agtctgtacc tgaaaggagc      840

acaattaatt ggcggtccaa aagccagcat tttgagctgt gcagaaccat taagtagcgc      900

gctactctct ttgctgttgc tggggatcac gttcacatta ccggactggc tgggaacgct      960

gctgattctg tcatcggtga ttttgatttc aatggattcc cgtcgccgcg ccagaaaaat     1020

aaatcgtccg gcgcggcata agtga                                           1045


<210>  31
<211>  2470
<212>  DNA
<213>  Escherichia coli

<400>  31
caagggacaa tttttgcagc ggcacagcgt tcagatagtt attttgttaa atgtattaac       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgctgagt ttatacgaaa agataaagat aaggctgata attttatttt tattggcagc      180

actgtcattt attggtcttt ttttcatcat taactatcaa ctggtatcgg agcgcgcggt      240

aaaacgtgcc gatagccgct ttgaacttat tcagaaaaac gttggctatt tctttaaaga      300

tattgaacgt tcggccctga cattaaagga ctcactgtat ttattaaaaa atacagagga      360

gattcaacgc gccgtgattc ttaaaatgga aatgatgcca tttttagact cggtgggact      420

ggtacttgat gataataaat attatctttt ttcgcggagg gcgaatgata aaatcgttgt      480

ttatcatcag gaacaagtaa atggaccgct tgtcgacgag tcagggcggg ttatttttgc      540

cgattttaac ccatcgaaac gaccgtggtc ggtggcttca gatgactcta acaacagctg      600

gaatccggca tacaattgct ttgatcgtcc gggtaaaaaa tgtatctctt ttacgctaca      660

catcaacggc aaagatcacg atttgttagc ggtggataaa attcatgtcg atttaaactg      720

gcgatatctg aacgagtatc ttgatcaaat cagcgctaat gatgaagttc tatttttgaa      780

acaaggccat gagatcattg ccaagaatca actcgctcgt gaaaaactga ttatttataa      840

tagcgaaggt aattataata ttattgattc tgtcgatact gaatatatcg aaaaaacatc      900

agcggtgcca aacaacgcat tattcgaaat ctatttttat tatcctggcg gtaatttatt      960

gaacgcatca gataaacttt tttatctgcc gtttgcgttc attattatcg tattgctggt     1020

ggtttattta atgaccactc gtgtgttccg tcggcaattt tctgaaatga cagagctggt     1080

taatacgctg gcgtttttgc ctgactcaac ggatcaaatc gaggctctga aaattcgtga     1140

aggcgatgcg aaagagatta tcagcatcaa aaattcgatc gcggaaatga aagatgccga     1200

aattgaacgg tcaaataaat tgctctcact gatctcttac gatcaggaaa gtggttttat     1260

taaaaatatg gcgattattg agtctaacaa taatcagtat ctggctgtgg ggatcatcaa     1320

actgtgtggt ctggaagccg tggaagcggt gtttggtgtt gatgagcgca ataaaatcgt     1380

caggaaattg tgtcagcgaa ttgccgagaa atatgcgcaa tgctgcgata tcgtgacatt     1440

caatgccgat ctctatttac ttctgtgtcg ggaaaatgta cagacattta cccgtaaaat     1500

agcgatggta aacgattttg acagcagctt tggctaccgc aatctgcgca tccataagtc     1560

tgccatttgt gaacctttgc agggggaaaa cgcctggagt tacgcagaaa aactgaaact     1620

ggcgatttcc agtatccgtg accatatgtt ctcagagttt attttctgtg atgacgcgaa     1680

actcaacgaa atagaagaga atatctggat tgcgcgtaat attcgccatg caatggaaat     1740

tggcgaacta ttcctcgtct atcaaccgat cgttgatatt aacacccgcg ccattctggg     1800

cgcggaggcg ttgtgccgtt gggtgtctgc ggagcggggg atcatttcac cgctgaagtt     1860

cattaccatt gctgaagata tcgggtttat caatgagctg ggttatcaga ttattaaaac     1920

ggcaatgggt gaattcagac attttagtca gcgtgcgtcg ctgaaggatg atttcttact     1980

gcatattaat gtttcgccct ggcagttaaa cgaaccacac tttcatgagc gttttaccac     2040

catcatgaaa gaaaatggcc tgaaggcgaa cagcctctgt gttgagatca ctgaaaccgt     2100

gatcgagcga attaatgaac atttttatct caatattgaa caactgcgta aacaaggggt     2160

acggatatcg attgatgact ttggcaccgg tttgtcaaac ctgaaacgtt tttatgaaat     2220

taatccagac agcataaagg tggactcgca attcaccggc gatattttcg gtactgcggg     2280

aaaaattgtg cgcattattt tcgacctggc acgctataac cggatcccgg tgattgcgga     2340

aggcgtagag agcgaagacg ttgcgcgcga attaatcaaa ttaggatgtg ttcaggctca     2400

ggggtatctg taccagaaac ccatgccatt ctccgcctgg gataaaagtg gaaaattagt     2460

aaaagagtag                                                            2470


<210>  32
<211>  883
<212>  DNA
<213>  Escherichia coli

<400>  32
aacgctgatg atatgcgcct tctatactta acgtttattc agcgttaagt ggagaactcg       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatggcacag gttgcgatta ttaccgcctc cgattcgggg atcggcaaag agtgcgcgtt      180

attactggcg cagcaggggt ttgatattgg tattacctgg cactcagatg aagaaggggc      240

aaaagatacc gcgcgtgagg tagttagcca cggcgtacgt gcggagatcg tgcagctgga      300

tctcggcaat ctaccagaag gggcactggc gctggagaaa ctcattcaac ggctggggcg      360

cattgatgtg ctggtgaata atgcgggtgc aatgaccaaa gcgccgtttc ttgatatggc      420

ttttgatgag tggcgcaaga tttttaccgt tgatgtcgat ggtgcattct tatgctcgca      480

aattgcggct cgtcagatgg tgaaacaagg gcagggcggt cgcatcatca acattacgtc      540

ggtacatgaa catacgccgc tgccggatgc cagcgcctac acagccgcta aacatgcgct      600

cggtgggtta accaaagcga tggcgctgga gctggtcagg cataagattt tggtgaacgc      660

agtcgcgcct ggggcgatcg ccacgccaat gaatggcatg gatgacagcg acgtgaagcc      720

cgacgcggag ccttcgattc ccttgcggcg ttttggcgca acgcatgaga ttgccagcct      780

ggtggtgtgg ctttgttcgg agggcgcaaa ttacaccacc gggcagtcgt tgatagtgga      840

tggcggcttt atgttggcga atccacagtt caacccagaa tag                        883


<210>  33
<211>  14
<212>  PRT
<213>  Escherichia coli

<400>  33

Met Arg Ile Phe Val Tyr Gly Ser Leu Arg His Lys Gln Gly 
1               5                   10                  


<210>  34
<211>  93
<212>  PRT
<213>  Escherichia coli

<400>  34

Met Ser Arg Arg Asn Thr Asp Ala Ile Thr Ile His Ser Ile Leu Asp 
1               5                   10                  15      


Trp Ile Glu Asp Asn Leu Glu Ser Pro Leu Ser Leu Glu Lys Val Ser 
            20                  25                  30          


Glu Arg Ser Gly Tyr Ser Lys Trp His Leu Gln Arg Met Phe Lys Lys 
        35                  40                  45              


Glu Thr Gly His Ser Leu Gly Gln Tyr Ile Arg Ser Arg Lys Met Thr 
    50                  55                  60                  


Glu Ile Ala Gln Lys Leu Lys Glu Ser Asn Glu Pro Ile Leu Tyr Leu 
65                  70                  75                  80  


Ala Glu Arg Tyr Gly Phe Glu Ser Gln Gln Thr Leu Thr 
                85                  90              


<210>  35
<211>  127
<212>  PRT
<213>  Escherichia coli

<400>  35

Met Ser Arg Arg Asn Thr Asp Ala Ile Thr Ile His Ser Ile Leu Asp 
1               5                   10                  15      


Trp Ile Glu Asp Asn Leu Glu Ser Pro Leu Ser Leu Glu Lys Val Ser 
            20                  25                  30          


Glu Arg Ser Gly Tyr Ser Lys Trp His Leu Gln Arg Met Phe Lys Lys 
        35                  40                  45              


Glu Thr Gly His Ser Leu Gly Gln Tyr Ile Arg Ser Arg Lys Met Thr 
    50                  55                  60                  


Glu Ile Ala Gln Lys Leu Lys Glu Ser Asn Glu Pro Ile Leu Tyr Leu 
65                  70                  75                  80  


Ala Glu Arg Tyr Gly Phe Glu Ser Gln Gln Thr Leu Thr Arg Thr Phe 
                85                  90                  95      


Lys Asn Tyr Phe Asp Val Pro Pro His Lys Lys Arg Met Thr Asn Met 
            100                 105                 110         


Gln Gly Glu Ser Arg Phe Leu His Pro Leu Asn His Tyr Asn Ser 
        115                 120                 125         


<210>  36
<211>  810
<212>  PRT
<213>  Escherichia coli

<400>  36

Met Ser Val Ile Ala Gln Ala Gly Ala Lys Gly Arg Gln Leu His Lys 
1               5                   10                  15      


Phe Gly Gly Ser Ser Leu Ala Asp Val Lys Cys Tyr Leu Arg Val Ala 
            20                  25                  30          


Gly Ile Met Ala Glu Tyr Ser Gln Pro Asp Asp Met Met Val Val Ser 
        35                  40                  45              


Ala Ala Gly Ser Thr Thr Asn Gln Leu Ile Asn Trp Leu Lys Leu Ser 
    50                  55                  60                  


Gln Thr Asp Arg Leu Ser Ala His Gln Val Gln Gln Thr Leu Arg Arg 
65                  70                  75                  80  


Tyr Gln Cys Asp Leu Ile Ser Gly Leu Leu Pro Ala Glu Glu Ala Asp 
                85                  90                  95      


Ser Leu Ile Ser Ala Phe Val Ser Asp Leu Glu Arg Leu Ala Ala Leu 
            100                 105                 110         


Leu Asp Ser Gly Ile Asn Asp Ala Val Tyr Ala Glu Val Val Gly His 
        115                 120                 125             


Gly Glu Val Trp Ser Ala Arg Leu Met Ser Ala Val Leu Asn Gln Gln 
    130                 135                 140                 


Gly Leu Pro Ala Ala Trp Leu Asp Ala Arg Glu Phe Leu Arg Ala Glu 
145                 150                 155                 160 


Arg Ala Ala Gln Pro Gln Val Asp Glu Gly Leu Ser Tyr Pro Leu Leu 
                165                 170                 175     


Gln Gln Leu Leu Val Gln His Pro Gly Lys Arg Leu Val Val Thr Gly 
            180                 185                 190         


Phe Ile Ser Arg Asn Asn Ala Gly Glu Thr Val Leu Leu Gly Arg Asn 
        195                 200                 205             


Gly Ser Asp Tyr Ser Ala Thr Gln Ile Gly Ala Leu Ala Gly Val Ser 
    210                 215                 220                 


Arg Val Thr Ile Trp Ser Asp Val Ala Gly Val Tyr Ser Ala Asp Asp 
225                 230                 235                 240 


Arg Lys Val Lys Asp Ala Cys Leu Leu Pro Leu Leu Arg Leu Asp Glu 
                245                 250                 255     


Ala Ser Glu Leu Ala Arg Leu Ala Ala Pro Val Leu His Ala Arg Thr 
            260                 265                 270         


Leu Gln Pro Val Ser Gly Ser Glu Ile Asp Leu Gln Leu Arg Cys Ser 
        275                 280                 285             


Tyr Thr Pro Asp Gln Gly Ser Thr Arg Ile Glu Arg Val Leu Ala Ser 
    290                 295                 300                 


Gly Thr Gly Ala Arg Ile Val Thr Ser His Asp Asp Val Cys Leu Ile 
305                 310                 315                 320 


Glu Phe Gln Val Pro Ala Ser Gln Asp Phe Lys Leu Ala His Lys Glu 
                325                 330                 335     


Ile Asp Gln Ile Leu Lys Arg Ala Gln Val Arg Pro Leu Ala Val Gly 
            340                 345                 350         


Val His Asn Asp Arg Gln Leu Leu Gln Phe Cys Tyr Thr Ser Glu Val 
        355                 360                 365             


Ala Asp Ser Ala Leu Lys Ile Leu Asp Glu Ala Gly Leu Pro Gly Glu 
    370                 375                 380                 


Leu Arg Leu Arg Gln Gly Leu Ala Leu Val Ala Met Val Gly Ala Gly 
385                 390                 395                 400 


Val Thr Arg Asn Pro Leu His Cys His Arg Phe Trp Gln Gln Leu Lys 
                405                 410                 415     


Gly Gln Pro Val Glu Phe Thr Trp Gln Ser Asp Asp Gly Ile Ser Leu 
            420                 425                 430         


Val Ala Val Leu Arg Thr Gly Pro Thr Glu Ser Leu Ile Gln Gly Leu 
        435                 440                 445             


His Gln Ser Val Phe Arg Ala Glu Lys Arg Ile Gly Leu Val Leu Phe 
    450                 455                 460                 


Gly Lys Gly Asn Ile Gly Ser Arg Trp Leu Glu Leu Phe Ala Arg Glu 
465                 470                 475                 480 


Gln Ser Thr Leu Ser Ala Arg Thr Gly Phe Glu Phe Val Leu Ala Gly 
                485                 490                 495     


Val Val Asp Ser Arg Arg Ser Leu Leu Ser Tyr Asp Gly Leu Asp Ala 
            500                 505                 510         


Ser Arg Ala Leu Ala Phe Phe Asn Asp Glu Ala Val Glu Gln Asp Glu 
        515                 520                 525             


Glu Ser Leu Phe Leu Trp Met Arg Ala His Pro Tyr Asp Asp Leu Val 
    530                 535                 540                 


Val Leu Asp Val Thr Ala Ser Gln Gln Leu Ala Asp Gln Tyr Leu Asp 
545                 550                 555                 560 


Phe Ala Ser His Gly Phe His Val Ile Ser Ala Asn Lys Leu Ala Gly 
                565                 570                 575     


Ala Ser Asp Ser Asn Lys Tyr Arg Gln Ile His Asp Ala Phe Glu Lys 
            580                 585                 590         


Thr Gly Arg His Trp Leu Tyr Asn Ala Thr Val Gly Ala Gly Leu Pro 
        595                 600                 605             


Ile Asn His Thr Val Arg Asp Leu Ile Asp Ser Gly Asp Thr Ile Leu 
    610                 615                 620                 


Ser Ile Ser Gly Ile Phe Ser Gly Thr Leu Ser Trp Leu Phe Leu Gln 
625                 630                 635                 640 


Phe Asp Gly Ser Val Pro Phe Thr Glu Leu Val Asp Gln Ala Trp Gln 
                645                 650                 655     


Gln Gly Leu Thr Glu Pro Asp Pro Arg Asp Asp Leu Ser Gly Lys Asp 
            660                 665                 670         


Val Met Arg Lys Leu Val Ile Leu Ala Arg Glu Ala Gly Tyr Asn Ile 
        675                 680                 685             


Glu Pro Asp Gln Val Arg Val Glu Ser Leu Val Pro Ala His Cys Glu 
    690                 695                 700                 


Gly Gly Ser Ile Asp His Phe Phe Glu Asn Gly Asp Glu Leu Asn Glu 
705                 710                 715                 720 


Gln Met Val Gln Arg Leu Glu Ala Ala Arg Glu Met Gly Leu Val Leu 
                725                 730                 735     


Arg Tyr Val Ala Arg Phe Asp Ala Asn Gly Lys Ala Arg Val Gly Val 
            740                 745                 750         


Glu Ala Val Arg Glu Asp His Pro Leu Ala Ser Leu Leu Pro Cys Asp 
        755                 760                 765             


Asn Val Phe Ala Ile Glu Ser Arg Trp Tyr Arg Asp Asn Pro Leu Val 
    770                 775                 780                 


Ile Arg Gly Pro Gly Ala Gly Arg Asp Val Thr Ala Gly Ala Ile Gln 
785                 790                 795                 800 


Ser Asp Ile Asn Arg Leu Ala Gln Leu Leu 
                805                 810 


<210>  37
<211>  810
<212>  PRT
<213>  Escherichia coli

<400>  37

Met Ser Val Ile Ala Gln Ala Gly Ala Lys Gly Arg Gln Leu His Lys 
1               5                   10                  15      


Phe Gly Gly Ser Ser Leu Ala Asp Val Lys Cys Tyr Leu Arg Val Ala 
            20                  25                  30          


Gly Ile Met Ala Glu Tyr Ser Gln Pro Asp Asp Met Met Val Val Ser 
        35                  40                  45              


Ala Ala Gly Ser Thr Thr Asn Gln Leu Ile Asn Trp Leu Lys Leu Ser 
    50                  55                  60                  


Gln Thr Asp Arg Leu Ser Ala His Gln Val Gln Gln Thr Leu Arg Arg 
65                  70                  75                  80  


Tyr Gln Cys Asp Leu Ile Ser Gly Leu Leu Pro Ala Glu Glu Ala Asp 
                85                  90                  95      


Ser Leu Ile Ser Ala Phe Val Ser Asp Leu Glu Arg Leu Ala Ala Leu 
            100                 105                 110         


Leu Asp Ser Gly Ile Asn Asp Ala Val Tyr Ala Glu Val Val Gly His 
        115                 120                 125             


Gly Glu Val Trp Ser Ala Arg Leu Met Ser Ala Val Leu Asn Gln Gln 
    130                 135                 140                 


Gly Leu Pro Ala Ala Trp Leu Asp Ala Arg Glu Phe Leu Arg Ala Glu 
145                 150                 155                 160 


Arg Ala Ala Gln Pro Gln Val Asp Glu Gly Leu Ser Tyr Pro Leu Leu 
                165                 170                 175     


Gln Gln Leu Leu Val Gln His Pro Gly Lys Arg Leu Val Val Thr Gly 
            180                 185                 190         


Phe Ile Ser Arg Asn Asn Ala Gly Glu Thr Val Leu Leu Gly Arg Asn 
        195                 200                 205             


Gly Ser Asp Tyr Ser Ala Thr Gln Ile Gly Ala Leu Ala Gly Val Ser 
    210                 215                 220                 


Arg Val Thr Ile Trp Ser Asp Val Ala Gly Cys Tyr Ser Ala Asp Pro 
225                 230                 235                 240 


Arg Lys Val Lys Asp Ala Cys Leu Leu Pro Leu Leu Arg Leu Asp Glu 
                245                 250                 255     


Ala Ser Glu Leu Ala Arg Leu Ala Ala Pro Val Leu His Ala Arg Thr 
            260                 265                 270         


Leu Gln Pro Val Ser Gly Ser Glu Ile Asp Leu Gln Leu Arg Cys Ser 
        275                 280                 285             


Tyr Thr Pro Asp Gln Gly Ser Thr Arg Ile Glu Arg Val Leu Ala Ser 
    290                 295                 300                 


Gly Thr Gly Ala Arg Ile Val Thr Ser His Asp Asp Val Cys Leu Ile 
305                 310                 315                 320 


Glu Phe Gln Val Pro Ala Ser Gln Asp Phe Lys Leu Ala His Lys Glu 
                325                 330                 335     


Ile Asp Gln Ile Leu Lys Arg Ala Gln Val Arg Pro Leu Ala Val Gly 
            340                 345                 350         


Val His Asn Asp Arg Gln Leu Leu Gln Phe Cys Tyr Thr Ser Glu Val 
        355                 360                 365             


Ala Asp Ser Ala Leu Lys Ile Leu Asp Glu Ala Gly Leu Pro Gly Glu 
    370                 375                 380                 


Leu Arg Leu Arg Gln Gly Leu Ala Leu Val Ala Met Val Gly Ala Gly 
385                 390                 395                 400 


Val Thr Arg Asn Pro Leu His Cys His Arg Phe Trp Gln Gln Leu Lys 
                405                 410                 415     


Gly Gln Pro Val Glu Phe Thr Trp Gln Ser Asp Asp Gly Ile Ser Leu 
            420                 425                 430         


Val Ala Val Leu Arg Thr Gly Pro Thr Glu Ser Leu Ile Gln Gly Leu 
        435                 440                 445             


His Gln Ser Val Phe Arg Ala Glu Lys Arg Ile Gly Leu Val Leu Phe 
    450                 455                 460                 


Gly Lys Gly Asn Ile Gly Ser Arg Trp Leu Glu Leu Phe Ala Arg Glu 
465                 470                 475                 480 


Gln Ser Thr Leu Ser Ala Arg Thr Gly Phe Glu Phe Val Leu Ala Gly 
                485                 490                 495     


Val Val Asp Ser Arg Arg Ser Leu Leu Ser Tyr Asp Gly Leu Asp Ala 
            500                 505                 510         


Ser Arg Ala Leu Ala Phe Phe Asn Asp Glu Ala Val Glu Gln Asp Glu 
        515                 520                 525             


Glu Ser Leu Phe Leu Trp Met Arg Ala His Pro Tyr Asp Asp Leu Val 
    530                 535                 540                 


Val Leu Asp Val Thr Ala Ser Gln Gln Leu Ala Asp Gln Tyr Leu Asp 
545                 550                 555                 560 


Phe Ala Ser His Gly Phe His Val Ile Ser Ala Asn Lys Leu Ala Gly 
                565                 570                 575     


Ala Ser Asp Ser Asn Lys Tyr Arg Gln Ile His Asp Ala Phe Glu Lys 
            580                 585                 590         


Thr Gly Arg His Trp Leu Tyr Asn Ala Thr Val Gly Ala Gly Leu Pro 
        595                 600                 605             


Ile Asn His Thr Val Arg Asp Leu Ile Asp Ser Gly Asp Thr Ile Leu 
    610                 615                 620                 


Ser Ile Ser Gly Ile Phe Ser Gly Thr Leu Ser Trp Leu Phe Leu Gln 
625                 630                 635                 640 


Phe Asp Gly Ser Val Pro Phe Thr Glu Leu Val Asp Gln Ala Trp Gln 
                645                 650                 655     


Gln Gly Leu Thr Glu Pro Asp Pro Arg Asp Asp Leu Ser Gly Lys Asp 
            660                 665                 670         


Val Met Arg Lys Leu Val Ile Leu Ala Arg Glu Ala Gly Tyr Asn Ile 
        675                 680                 685             


Glu Pro Asp Gln Val Arg Val Glu Ser Leu Val Pro Ala His Cys Glu 
    690                 695                 700                 


Gly Gly Ser Ile Asp His Phe Phe Glu Asn Gly Asp Glu Leu Asn Glu 
705                 710                 715                 720 


Gln Met Val Gln Arg Leu Glu Ala Ala Arg Glu Met Gly Leu Val Leu 
                725                 730                 735     


Arg Tyr Val Ala Arg Phe Asp Ala Asn Gly Lys Ala Arg Val Gly Val 
            740                 745                 750         


Glu Ala Val Arg Glu Asp His Pro Leu Ala Ser Leu Leu Pro Cys Asp 
        755                 760                 765             


Asn Val Phe Ala Ile Glu Ser Arg Trp Tyr Arg Asp Asn Pro Leu Val 
    770                 775                 780                 


Ile Arg Gly Pro Gly Ala Gly Arg Asp Val Thr Ala Gly Ala Ile Gln 
785                 790                 795                 800 


Ser Asp Ile Asn Arg Leu Ala Gln Leu Leu 
                805                 810 


<210>  38
<211>  540
<212>  PRT
<213>  Escherichia coli

<400>  38

Met Arg Val Asn Asn Gly Leu Thr Pro Gln Glu Leu Glu Ala Tyr Gly 
1               5                   10                  15      


Ile Ser Asp Val His Asp Ile Val Tyr Asn Pro Ser Tyr Asp Leu Leu 
            20                  25                  30          


Tyr Gln Glu Glu Leu Asp Pro Ser Leu Thr Gly Tyr Glu Arg Gly Val 
        35                  40                  45              


Leu Thr Asn Leu Gly Ala Val Ala Val Asp Thr Gly Ile Phe Thr Asp 
    50                  55                  60                  


Arg Ser Pro Lys Asp Lys Tyr Ile Val Arg Asp Asp Thr Thr Arg Asp 
65                  70                  75                  80  


Thr Phe Trp Trp Ala Asp Lys Gly Lys Gly Lys Asn Asp Asn Lys Pro 
                85                  90                  95      


Leu Ser Pro Glu Thr Trp Gln His Leu Lys Gly Leu Val Thr Arg Gln 
            100                 105                 110         


Leu Ser Gly Lys Arg Leu Phe Val Val Asp Ala Phe Cys Gly Ala Asn 
        115                 120                 125             


Pro Asp Thr Arg Leu Ser Val Arg Phe Ile Thr Glu Val Ala Trp Gln 
    130                 135                 140                 


Ala His Phe Val Lys Asn Met Phe Ile Arg Pro Ser Asp Glu Glu Leu 
145                 150                 155                 160 


Ala Gly Phe Lys Pro Asp Phe Ile Val Met Asn Gly Ala Lys Cys Thr 
                165                 170                 175     


Asn Pro Gln Trp Lys Glu Gln Gly Leu Asn Ser Glu Asn Phe Val Ala 
            180                 185                 190         


Phe Asn Leu Thr Glu Arg Met Gln Leu Ile Gly Gly Thr Trp Tyr Gly 
        195                 200                 205             


Gly Glu Met Lys Lys Gly Met Phe Ser Met Met Asn Tyr Leu Leu Pro 
    210                 215                 220                 


Leu Lys Gly Ile Ala Ser Met His Cys Ser Ala Asn Val Gly Glu Lys 
225                 230                 235                 240 


Gly Asp Val Ala Val Phe Phe Gly Leu Ser Gly Thr Gly Lys Thr Thr 
                245                 250                 255     


Leu Ser Thr Asp Pro Lys Arg Arg Leu Ile Gly Asp Asp Glu His Gly 
            260                 265                 270         


Trp Asp Asp Asp Gly Val Phe Asn Phe Glu Gly Gly Cys Tyr Ala Lys 
        275                 280                 285             


Thr Ile Lys Leu Ser Lys Glu Ala Glu Pro Glu Ile Tyr Asn Ala Ile 
    290                 295                 300                 


Arg Arg Asp Ala Leu Leu Glu Asn Val Thr Val Arg Glu Asp Gly Thr 
305                 310                 315                 320 


Ile Asp Phe Asp Asp Gly Ser Lys Thr Glu Asn Thr Arg Val Ser Tyr 
                325                 330                 335     


Pro Ile Tyr His Ile Asp Asn Ile Val Lys Pro Val Ser Lys Ala Gly 
            340                 345                 350         


His Ala Thr Lys Val Ile Phe Leu Thr Ala Asp Ala Phe Gly Val Leu 
        355                 360                 365             


Pro Pro Val Ser Arg Leu Thr Ala Asp Gln Thr Gln Tyr His Phe Leu 
    370                 375                 380                 


Ser Gly Phe Thr Ala Lys Leu Ala Gly Thr Glu Arg Gly Ile Thr Glu 
385                 390                 395                 400 


Pro Thr Pro Thr Phe Ser Ala Cys Phe Gly Ala Ala Phe Leu Ser Leu 
                405                 410                 415     


His Pro Thr Gln Tyr Ala Glu Val Leu Val Lys Arg Met Gln Ala Ala 
            420                 425                 430         


Gly Ala Gln Ala Tyr Leu Val Asn Thr Gly Trp Asn Gly Thr Gly Lys 
        435                 440                 445             


Arg Ile Ser Ile Lys Asp Thr Arg Ala Ile Ile Asp Ala Ile Leu Asn 
    450                 455                 460                 


Gly Ser Leu Asp Asn Ala Glu Thr Phe Thr Leu Pro Met Phe Asn Leu 
465                 470                 475                 480 


Ala Ile Pro Thr Glu Leu Pro Gly Val Asp Thr Lys Ile Leu Asp Pro 
                485                 490                 495     


Arg Asn Thr Tyr Ala Ser Pro Glu Gln Trp Gln Glu Lys Ala Glu Thr 
            500                 505                 510         


Leu Ala Lys Leu Phe Ile Asp Asn Phe Asp Lys Tyr Thr Asp Thr Pro 
        515                 520                 525             


Ala Gly Ala Ala Leu Val Ala Ala Gly Pro Lys Leu 
    530                 535                 540 


<210>  39
<211>  1303
<212>  DNA
<213>  Escherichia coli

<400>  39
tgtttatttt ctgacaagca gcgtaaactc cgcgtcttcc tcttccagtg atcgaccagc       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgcataac tcccccgcag tctccagcgc gaaatcgttt gacctgacct cgacggcgtt      180

tttaatcgtt gcctttctca ccggtattgc gggcgctctg caaaccccga cactcagtat      240

ttttcttacc gatgaagtac atgcccgtcc ggcgatggtg ggattcttct ttaccggcag      300

cgctgtcatt gggattctgg taagtcagtt tctcgccggg cgctctgata agcgcggcga      360

tcgcaaatcg ctgattgtct tttgctgcct gttaggcgtg ctggcctgca ccctttttgc      420

ctggaatcgc aactactttg ttttgctatt cgttggcgtc tttcttagca gctttggctc      480

gaccgctaac ccgcaaatgt ttgcccttgc ccgtgaacat gccgacaaaa ccggacgtga      540

ggcggtgatg ttcagctctt ttttacgcgc tcaggtttca ctggcatggg tcattggccc      600

accgctggct tatgccttag cgatgggttt cagctttacg gtaatgtatc tgagcgcagc      660

ggtagcgttt attgtttgcg gtgtgatggt gtggctgttt ttaccgtcga tgcgaaaaga      720

gcttccgctg gcgaccggca cgatcgaagc gccgcgccgt aaccgtcgcg atacgctgct      780

gctgtttgtc atttgtacat tgatgtgggg ctcgaacagc ctgtacatca tcaacatgcc      840

gctatttatt atcaacgaac tgcatcttcc cgagaaactg gccggtgtga tgatggggac      900

cgccgccggg ctggaaatcc cgacgatgtt gattgccgga tatttcgcca aacgtctggg      960

taagcgtttc ttaatgcgcg ttgctgccgt gggtggcgtc tgtttttacg caggaatgct     1020

gatggcgcat tcacctgtca ttctgttggg cttgcagctg ctaaatgcta tttttattgg     1080

cattctgggc ggcatcggga tgctctattt tcaggatctg atgcccggtc aggcgggttc     1140

agccaccacg ctctatacca acacttcgcg cgtgggctgg atcatcgcag gatcagtggc     1200

gggcatcgtc gccgagatct ggaattatca cgctgtgttc tggtttgcga tggtgatgat     1260

tatcgccact ctgttttgct tactgcggat taaagatgtt taa                       1303


<210>  40
<211>  532
<212>  DNA
<213>  Escherichia coli

<400>  40
tgaagcaatt tagataatcg tgcagactac gccccctcat atcacatgga aggtttatct       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatggatcag gtagtcattt ttaaacaaat atttgataaa gttcgaaacg atttaaacta      180

tcaatggttt tattctgagc taaaacgtca caatgtctca cattacattt actatttagc      240

cacagagaat gttcatattg tattaaaaaa tgataataca gtgttattaa agggcctaaa      300

aaacattgtg tctgtcaaat tttcaaagga taggcatctt atagaaacga cctctaataa      360

gctgaaatcc agagagatca catttcagga atacagaaga aaccttgcta aagcaggagt      420

ttttcggtgg gttacaaata tccacgaaca aaaaagatat tactatacct ttgataattc      480

attactattt actgaaagca tccagaaaac tacacagatc ttaccacgct aa              532


<210>  41
<211>  943
<212>  DNA
<213>  Escherichia coli

<400>  41
cgtctatagt atttatgagg gtttgctttt aataatcata attacccacc agagtgtgat       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

aatgcgtaca accattgctg tagtgttggg tgcaattagt ttgacgtctg cttttgtgtt      180

tgcagataaa ccagacgttg ccagatcggc aaacgatgag gtcagcaccc tgttttttgg      240

tcatgatgat cgtgtgccag tgaatgacac gacccaatca ccgtgggatg cggttgggca      300

actggaaacg gccagcggca atttatgtac ggcgacgctg attgcaccca atctggcatt      360

aacggcagga cactgtttat tgacacctcc aaagggtaaa gccgataaag cagtggcgct      420

gcgttttgtg tcaaataaag gtctttggcg ctatgagatc cacgacatag aaggccgcgt      480

tgatccgaca ctgggaaagc ggttaaaagc agatggggat ggttggattg tacctcccgc      540

agccgcgccg tgggacttcg gattgattgt gctacgtaat cccccttctg gcattacgcc      600

gttgccgtta tttgagggag ataaagccgc gcttaccgcc gcattaaaag cggcaggtcg      660

taaagtgact caggcaggct accctgaaga tcatctcgat acgttgtaca gtcatcaaaa      720

ctgtgaagtg actggctggg cgcaaacgtc ggtgatgtca catcagtgcg ataccttgcc      780

gggtgacagc ggttcgcctc tgatgttgca taccgatgac ggctggcaat taattggggt      840

gcaaagttcg gctcctgccg cgaaagatcg ctggcgcgcc gataaccggg ccatttctgt      900

taccggtttt cgcgacaagc tggatcaact gtcgcaaaaa taa                        943


<210>  42
<211>  466
<212>  DNA
<213>  Escherichia coli

<400>  42
atgatgtgtt aaaattgatg taaacaaatt gtgaagtgaa tgtgcttccg gggaaaataa       60

ttgacggcta gctcagtcct aggtacagtg ctagctaagt aggtacgtaa ggaggtgata      120

agtgacttca ttacaactct caatcgtcca tcgactgccg cagaactatc gctggtctgc      180

tggtttcgca ggttcgaagg ttgaaccgat tccgcaaaat ggaccgtgcg gtgacaacag      240

cctggtggcg cttaaattgc ttagcccgga tggtgataat gcatggtcgg tgatgtataa      300

actaagccag gcgttaagcg acatcgaagt tccatgttcg gtgctggagt gtgaaggtga      360

gccgtgcctg tttgtaaatc gccaggacga gtttgctgca acatgccgat tgaaaaattt      420

tggtgtggca attgccgaac ccttttcaaa ctacaatcct ttttaa                     466


