                         SEQUENCE LISTING

<110>  JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
 
<120>  Hepatitis B Virus (HBV) Vaccines and Uses Thereof

<130>  065814.11192/6WO1

<150>  EP19180926.8
<151>  2019-06-18

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen gene

<400>  1
gacatcgacc cttacaagga gttcggcgcc agcgtggaac tgctgtcttt tctgcccagt       60

gatttctttc cttccattcg agacctgctg gataccgcct ctgctctgta tcgggaagcc      120

ctggagagcc cagaacactg ctccccacac cataccgctc tgcgacaggc aatcctgtgc      180

tggggggagc tgatgaacct ggccacatgg gtgggatcga atctggagga ccccgcttca      240

cgggaactgg tggtcagcta cgtgaacgtc aatatgggcc tgaaaatccg ccagctgctg      300

tggttccata ttagctgcct gacttttgga cgagagaccg tgctggaata cctggtgtcc      360

ttcggcgtct ggattcgcac tccccctgct tatcgaccac ccaacgcacc aattctgtcc      420

accctgcccg agaccacagt ggtc                                             444


<210>  2
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen

<400>  2

Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu Ser 
1               5                   10                  15      


Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp Thr 
            20                  25                  30          


Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser 
        35                  40                  45              


Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 
    50                  55                  60                  


Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala Ser 
65                  70                  75                  80  


Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys Ile 
                85                  90                  95      


Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu 
            100                 105                 110         


Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro 
        115                 120                 125             


Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu 
    130                 135                 140                 


Thr Thr Val Val 
145             


<210>  3
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV pol antigen gene

<400>  3
atgcccctgt cttaccagca ctttagaaag cttctgctgc tggacgatga agccgggcct       60

ctggaggaag agctgccaag gctggcagac gaggggctga accggagagt ggccgaagat      120

ctgaatctgg gaaacctgaa cgtgagcatc ccttggactc ataaagtcgg caacttcacc      180

gggctgtaca gctccacagt gcctgtcttc aatccagagt ggcagacacc atcctttccc      240

aacattcacc tgcaggagga catcattaat agatgcgaac agttcgtggg acctctgaca      300

gtcaacgaaa agaggcgcct gaaactgatc atgcctgcca ggttttaccc aaatgtgact      360

aagtatctgc cactggataa gggcatcaag ccttactatc cagagcacct ggtgaaccat      420

tacttccaga ctagacacta tctgcatacc ctgtggaagg ccggaatcct gtacaaacga      480

gaaactaccc ggagtgcttc attttgtggc tccccatatt cttgggaaca ggagctgcag      540

catggcaggc tggtgttcca gaccagcaca cgccacgggg atgagtcctt ttgccagcag      600

tctagtggca tcctgagcag atcccccgtg gggccttgtc tgcagtctca gctgcggaag      660

agtagactgg gactgcagcc acagcaggga cacctggcac gacggcagca gggaaggtct      720

ggcagtatcc gggctagagt gcatcccaca actagaaggc ctttcggcgt cgagccatca      780

ggaagcggcc acaccacaaa caccgcatca agctcctcta gttgcctgca tcagtcagcc      840

gtgagaaagg ccgcttacag ccacctgtcc acatctaaaa ggcactcaag ctccgggcat      900

gctgtggagc tgcacaacat ccctccaaat tctgcacgca gtcagtcaga aggacccgtg      960

ttcagctgct ggtggctgca gtttcggaac tcaaagcctt gcagcgacta ttgtctgagc     1020

catattgtga atctgctgga ggattggggc ccttgtaccg agcacgggga acaccatatc     1080

aggattccac gaacaccagc acgagtgact ggaggggtgt tcctggtgga caagaacccc     1140

cacaatacta ccgagagccg gctggtggtc gatttcagtc agttttcaag aggcaacaca     1200

agggtgtcat ggcccaaatt cgccgtccct aatctgcaga gtctgactaa cctgctgtct     1260

agtaatctga gctggctgtc cctggacgtg tccgcagcct tttaccacct gcctctgcat     1320

ccagctgcaa tgccccatct gctggtgggg tcaagcggac tgagtcgcta cgtcgcccga     1380

ctgtcctcta actcacgcat cattaatcac cagcatggca ccatgcagaa cctgcacgat     1440

agctgttccc ggaatctgta cgtgtctctg ctgctgctgt ataagacatt cggcagaaaa     1500

ctgcacctgt acagccatcc tatcattctg gggtttagga agatcccaat gggagtggga     1560

ctgagcccct tcctgctggc acagtttacc tccgccattt gctctgtggt ccgccgagcc     1620

ttcccacact gtctggcttt ttcctatatg aacaatgtgg tcctgggcgc caaatccgtg     1680

cagcatctgg agtctctgtt cacagctgtc actaactttc tgctgagcct ggggatccac     1740

ctgaacccaa ataagactaa acgctggggg tacagcctga atttcatggg atatgtgatt     1800

ggatcctggg ggaccctgcc acaggagcac atcgtgcaga agatcaagga atgctttcgg     1860

aagctgcccg tcaacagacc tatcgactgg aaagtgtgcc agcggattgt cggactgctg     1920

ggcttcgccg ctccctttac ccagtgcggg tacccagcac tgatgcccct gtatgcctgt     1980

atccagtcta agcaggcttt cacctttagt cctacataca aggcattcct gtgcaaacag     2040

tacctgaacc tgtatccagt ggcaaggcag cgacctggac tgtgccaggt ctttgcaaat     2100

gccactccta ccggctgggg gctggctatc ggacatcagc gaatgcgggg cacattcgtg     2160

gcccccctgc ctattcacac tgctcagctg ctggcagcct gctttgctag atctaggagt     2220

ggagcaaagc tgatcggcac cgacaatagt gtggtcctgt caagaaaata cacatccttc     2280

ccatggctgc tgggatgtgc tgcaaactgg attctgaggg gcaccagctt cgtgtacgtc     2340

ccctcagccc tgaatcctgc tgacgatcca tcccgcgggc gactgggact gtaccgacct     2400

ctgctgagac tgcccttcag gcctacaact ggccggacat ctctgtatgc cgattcacca     2460

agcgtgccct cacacctgcc tgacagagtc cactttgctt cacccctgca cgtcgcttgg     2520

cggcctcca                                                             2529


<210>  4
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV pol antigen

<400>  4

Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu Leu Leu Asp Asp 
1               5                   10                  15      


Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 
            20                  25                  30          


Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 
        35                  40                  45              


Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser 
    50                  55                  60                  


Ser Thr Val Pro Val Phe Asn Pro Glu Trp Gln Thr Pro Ser Phe Pro 
65                  70                  75                  80  


Asn Ile His Leu Gln Glu Asp Ile Ile Asn Arg Cys Glu Gln Phe Val 
                85                  90                  95      


Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile Met Pro 
            100                 105                 110         


Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu Asp Lys Gly 
        115                 120                 125             


Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His Tyr Phe Gln Thr 
    130                 135                 140                 


Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 
145                 150                 155                 160 


Glu Thr Thr Arg Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp Glu 
                165                 170                 175     


Gln Glu Leu Gln His Gly Arg Leu Val Phe Gln Thr Ser Thr Arg His 
            180                 185                 190         


Gly Asp Glu Ser Phe Cys Gln Gln Ser Ser Gly Ile Leu Ser Arg Ser 
        195                 200                 205             


Pro Val Gly Pro Cys Leu Gln Ser Gln Leu Arg Lys Ser Arg Leu Gly 
    210                 215                 220                 


Leu Gln Pro Gln Gln Gly His Leu Ala Arg Arg Gln Gln Gly Arg Ser 
225                 230                 235                 240 


Gly Ser Ile Arg Ala Arg Val His Pro Thr Thr Arg Arg Pro Phe Gly 
                245                 250                 255     


Val Glu Pro Ser Gly Ser Gly His Thr Thr Asn Thr Ala Ser Ser Ser 
            260                 265                 270         


Ser Ser Cys Leu His Gln Ser Ala Val Arg Lys Ala Ala Tyr Ser His 
        275                 280                 285             


Leu Ser Thr Ser Lys Arg His Ser Ser Ser Gly His Ala Val Glu Leu 
    290                 295                 300                 


His Asn Ile Pro Pro Asn Ser Ala Arg Ser Gln Ser Glu Gly Pro Val 
305                 310                 315                 320 


Phe Ser Cys Trp Trp Leu Gln Phe Arg Asn Ser Lys Pro Cys Ser Asp 
                325                 330                 335     


Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu Asp Trp Gly Pro Cys 
            340                 345                 350         


Thr Glu His Gly Glu His His Ile Arg Ile Pro Arg Thr Pro Ala Arg 
        355                 360                 365             


Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr 
    370                 375                 380                 


Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn Thr 
385                 390                 395                 400 


Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr 
                405                 410                 415     


Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala 
            420                 425                 430         


Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala Met Pro His Leu Leu 
        435                 440                 445             


Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala Arg Leu Ser Ser Asn 
    450                 455                 460                 


Ser Arg Ile Ile Asn His Gln His Gly Thr Met Gln Asn Leu His Asp 
465                 470                 475                 480 


Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu Leu Leu Tyr Lys Thr 
                485                 490                 495     


Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 
            500                 505                 510         


Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln 
        515                 520                 525             


Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala Phe Pro His Cys 
    530                 535                 540                 


Leu Ala Phe Ser Tyr Met Asn Asn Val Val Leu Gly Ala Lys Ser Val 
545                 550                 555                 560 


Gln His Leu Glu Ser Leu Phe Thr Ala Val Thr Asn Phe Leu Leu Ser 
                565                 570                 575     


Leu Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr Ser 
            580                 585                 590         


Leu Asn Phe Met Gly Tyr Val Ile Gly Ser Trp Gly Thr Leu Pro Gln 
        595                 600                 605             


Glu His Ile Val Gln Lys Ile Lys Glu Cys Phe Arg Lys Leu Pro Val 
    610                 615                 620                 


Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu 
625                 630                 635                 640 


Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met Pro 
                645                 650                 655     


Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala Phe Thr Phe Ser Pro Thr 
            660                 665                 670         


Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu Asn Leu Tyr Pro Val Ala 
        675                 680                 685             


Arg Gln Arg Pro Gly Leu Cys Gln Val Phe Ala Asn Ala Thr Pro Thr 
    690                 695                 700                 


Gly Trp Gly Leu Ala Ile Gly His Gln Arg Met Arg Gly Thr Phe Val 
705                 710                 715                 720 


Ala Pro Leu Pro Ile His Thr Ala Gln Leu Leu Ala Ala Cys Phe Ala 
                725                 730                 735     


Arg Ser Arg Ser Gly Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val 
            740                 745                 750         


Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala 
        755                 760                 765             


Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 
    770                 775                 780                 


Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu Tyr Arg Pro 
785                 790                 795                 800 


Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly Arg Thr Ser Leu Tyr 
                805                 810                 815     


Ala Asp Ser Pro Ser Val Pro Ser His Leu Pro Asp Arg Val His Phe 
            820                 825                 830         


Ala Ser Pro Leu His Val Ala Trp Arg Pro Pro 
        835                 840             


<210>  5
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cystatin S signal peptide coding sequence

<400>  5
atggctcgac ctctgtgtac cctgctactc ctgatggcta ccctggctgg agctctggcc       60

agc                                                                     63


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cystatin S signal peptide sequence

<400>  6

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Ser 
            20      


<210>  7
<211>  586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCMV promoter sequence

<400>  7
tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc       60

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc      120

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      180

actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt ggcagtacat      240

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      300

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      360

ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag      420

cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt      480

tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa      540

atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctc                     586


<210>  8
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  triple enhancer regulatory sequence

<400>  8
ggctcgcatc tctccttcac gcgcccgccg ccctacctga ggccgccatc cacgccggtt       60

gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga actgcgtccg ccgtctaggt      120

aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg ctcccttgga gcctacctag      180

actcagccgg ctctccacgc tttgcctgac cctgcttgct caactctagt tctctcgtta      240

acttaatgag acagatagaa actggtcttg tagaaacaga gtagtcgcct gcttttctgc      300

caggtgctga cttctctccc ctgggctttt ttctttttct caggttgaaa agaagaagac      360

gaagaagacg aagaagac                                                    378


<210>  9
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bla promoter sequence

<400>  9
acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa       60

ccctgataaa tgcttcaata atattgaaaa aggaagagt                              99


<210>  10
<211>  671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC ori sequence

<400>  10
cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc       60

ttgcaaacaa aaaaaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca t                                                           671


<210>  11
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGH polyadenylation signal sequence

<400>  11
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  12
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan R gene

<400>  12
atgattgagc aagatggtct tcacgctggc tcgccagctg cgtgggtgga acgcctgttt       60

ggttatgatt gggcgcagca gactattgga tgttccgacg cggctgtatt tcggctgtct      120

gctcagggtc gccccgtgct gtttgtgaag acggatttgt ctggcgcatt aaatgagtta      180

caggacgagg cggctcgtct gagttggttg gccaccaccg gcgtgccctg cgccgcagtg      240

ctggatgtcg tgacagaagc aggccgcgat tggctccttc tcggcgaagt gccgggccag      300

gacctgctca gcagccactt ggcaccggca gaaaaagttt ctatcatggc cgacgccatg      360

cgtcgtcttc acactctcga tccggccacg tgcccctttg accaccaggc caagcatcgt      420

attgaacgtg cgcgtactcg gatggaagca ggtttagtag accaggacga tttggatgag      480

gaacatcaag gcctggcccc ggctgaactg tttgcgcgct taaaagcgtc gatgccagat      540

ggcgaagatt tggtagtcac ccatggagat gcgtgtttgc caaacatcat ggttgaaaat      600

ggccgcttct caggctttat tgactgtggg cgcctgggtg ttgccgaccg ctatcaagat      660

attgcgctcg caactcgtga catcgctgaa gagctgggcg gagaatgggc tgaccgtttc      720

ctggtactgt atggcattgc agcgcccgat tcccaacgca tcgcatttta tcgtctgctg      780

gatgagtttt tctaa                                                       795


<210>  13
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kan R protein

<400>  13

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  14
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen

<400>  14

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val 
145                 


<210>  15
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen gene

<400>  15
atggacatcg acccttacaa ggagttcggc gccagcgtgg aactgctgtc ttttctgccc       60

agtgatttct ttccttccat tcgagacctg ctggataccg cctctgctct gtatcgggaa      120

gccctggaga gcccagaaca ctgctcccca caccataccg ctctgcgaca ggcaatcctg      180

tgctgggggg agctgatgaa cctggccaca tgggtgggat ccaatctgga ggaccccgct      240

tcacgggaac tggtggtcag ctacgtgaac gtcaatatgg gcctgaaaat ccgccagctg      300

ctgtggttcc atattagctg cctgactttt ggacgagaga ccgtgctgga atacctggtg      360

tccttcggcg tctggatccg cactccccct gcttatcgac cacccaacgc accaattctg      420

tccaccctgc ccgagaccac agtggtc                                          447


<210>  16
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV pol antigen gene

<400>  16
atgcccctgt cttaccagca ctttagaaag ctgctgctgc tggacgatga agccgggcct       60

ctggaggaag agctgccaag gctggcagac gaggggctga accggagagt ggccgaagat      120

ctgaatctgg gaaacctgaa cgtgagcatc ccttggactc ataaagtcgg caacttcacc      180

gggctgtaca gctccacagt gcctgtcttc aatccagagt ggcagacacc atcctttccc      240

aacattcacc tgcaggagga catcattaat agatgcgaac agttcgtggg acctctgaca      300

gtcaacgaaa agaggcgcct gaaactgatc atgcctgcca ggttttaccc aaatgtgact      360

aagtatctgc cactggataa gggcatcaag ccttactatc cagagcacct ggtgaaccat      420

tacttccaga ctagacacta tctgcatacc ctgtggaagg ccggaatcct gtacaaacga      480

gaaactaccc ggagtgcttc attttgtggc tccccatatt cttgggaaca ggagctgcag      540

catggcaggc tggtgttcca gaccagcaca cgccacgggg atgagtcctt ttgccagcag      600

tctagtggca tcctgagcag atcccccgtg gggccttgtc tgcagtctca gctgcggaag      660

agtagactgg gactgcagcc acagcaggga cacctggcac gacggcagca gggaaggtct      720

ggcagtatcc gggctagagt gcatcccaca actagaaggc ctttcggcgt cgagccatca      780

ggaagcggcc acaccacaaa caccgcatca agctcctcta gttgcctgca tcagtcagcc      840

gtgagaaagg ccgcttacag ccacctgtcc acatctaaaa ggcactcaag ctccgggcat      900

gctgtggagc tgcacaacat ccctccaaat tctgcacgca gtcagtcaga aggacccgtg      960

ttcagctgct ggtggctgca gtttcggaac tcaaagcctt gcagcgacta ttgtctgagc     1020

catattgtga atctgctgga ggattggggc ccttgtaccg agcacgggga acaccatatc     1080

aggattccac gaacaccagc acgagtgact ggaggggtgt tcctggtgga caagaacccc     1140

cacaatacta ccgagagccg gctggtggtc gatttcagtc agttttcaag aggcaacaca     1200

agggtgtcat ggcccaaatt cgccgtccct aatctgcaga gtctgactaa cctgctgtct     1260

agtaatctga gctggctgtc cctggacgtg tccgcagcct tttaccacct gcctctgcat     1320

ccagctgcaa tgccccatct gctggtgggg tcaagcggac tgagtcgcta cgtcgcccga     1380

ctgtcctcta actcacgcat cattaatcac cagcatggca ccatgcagaa cctgcacgat     1440

agctgttccc ggaatctgta cgtgtctctg ctgctgctgt ataagacatt cggcagaaaa     1500

ctgcacctgt acagccatcc tatcattctg gggtttagga agatcccaat gggagtggga     1560

ctgagcccct tcctgctggc acagtttacc tccgccattt gctctgtggt ccgccgagcc     1620

ttcccacact gtctggcttt ttcctatatg aacaatgtgg tcctgggcgc caaatccgtg     1680

cagcatctgg agtctctgtt cacagctgtc actaactttc tgctgagcct ggggatccac     1740

ctgaacccaa ataagactaa acgctggggg tacagcctga atttcatggg atatgtgatt     1800

ggatcctggg ggaccctgcc acaggagcac atcgtgcaga agatcaagga atgctttcgg     1860

aagctgcccg tcaacagacc tatcgactgg aaagtgtgcc agcggattgt cggactgctg     1920

ggcttcgccg ctccctttac ccagtgcggg tacccagcac tgatgcccct gtatgcctgt     1980

atccagtcta agcaggcttt cacctttagt cctacataca aggcattcct gtgcaaacag     2040

tacctgaacc tgtatccagt ggcaaggcag cgacctggac tgtgccaggt ctttgcaaat     2100

gccactccta ccggctgggg gctggctatc ggacatcagc gaatgcgggg cacattcgtg     2160

gcccccctgc ctattcacac tgctcagctg ctggcagcct gctttgctag atctaggagt     2220

ggagcaaagc tgatcggcac cgacaatagt gtggtcctgt caagaaaata cacatccttc     2280

ccatggctgc tgggatgtgc tgcaaactgg attctgaggg gcaccagctt cgtgtacgtc     2340

ccctcagccc tgaatcctgc tgacgatcca tcccgcgggc gactgggact gtaccgacct     2400

ctgctgagac tgcccttcag gcctacaact ggccggacat ctctgtatgc cgattcacca     2460

agcgtgccct cacacctgcc tgacagagtc cactttgctt cacccctgca cgtcgcttgg     2520

cggcctcca                                                             2529


<210>  17
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCMV promoter sequence

<400>  17
accgccatgt tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt       60

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg      120

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac      180

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt      240

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa      300

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta      360

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg      420

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg      480

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc      540

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctcgttt      600

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagaca      660

ccgggaccga tccagcctcc gcgg                                             684


<210>  18
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  immunoglobulin secretion signal coding sequence

<400>  18
atggagttcg gcctgtcttg ggtctttctg gtggcaatcc tgaagggcgt gcagtgtgaa       60

gtgcagctgc tggagtctgg a                                                 81


<210>  19
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin secretion signal sequence

<400>  19

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25          


<210>  20
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core-pol fusion antigen sequence

<400>  20

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Ala Gly Ala Gly Met Pro Leu Ser Tyr Gln His 
145                 150                 155                 160 


Phe Arg Lys Leu Leu Leu Leu Asp Asp Glu Ala Gly Pro Leu Glu Glu 
                165                 170                 175     


Glu Leu Pro Arg Leu Ala Asp Glu Gly Leu Asn Arg Arg Val Ala Glu 
            180                 185                 190         


Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys 
        195                 200                 205             


Val Gly Asn Phe Thr Gly Leu Tyr Ser Ser Thr Val Pro Val Phe Asn 
    210                 215                 220                 


Pro Glu Trp Gln Thr Pro Ser Phe Pro Asn Ile His Leu Gln Glu Asp 
225                 230                 235                 240 


Ile Ile Asn Arg Cys Glu Gln Phe Val Gly Pro Leu Thr Val Asn Glu 
                245                 250                 255     


Lys Arg Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr Pro Asn Val 
            260                 265                 270         


Thr Lys Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr Pro Glu 
        275                 280                 285             


His Leu Val Asn His Tyr Phe Gln Thr Arg His Tyr Leu His Thr Leu 
    290                 295                 300                 


Trp Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr Thr Arg Ser Ala Ser 
305                 310                 315                 320 


Phe Cys Gly Ser Pro Tyr Ser Trp Glu Gln Glu Leu Gln His Gly Arg 
                325                 330                 335     


Leu Val Phe Gln Thr Ser Thr Arg His Gly Asp Glu Ser Phe Cys Gln 
            340                 345                 350         


Gln Ser Ser Gly Ile Leu Ser Arg Ser Pro Val Gly Pro Cys Leu Gln 
        355                 360                 365             


Ser Gln Leu Arg Lys Ser Arg Leu Gly Leu Gln Pro Gln Gln Gly His 
    370                 375                 380                 


Leu Ala Arg Arg Gln Gln Gly Arg Ser Gly Ser Ile Arg Ala Arg Val 
385                 390                 395                 400 


His Pro Thr Thr Arg Arg Pro Phe Gly Val Glu Pro Ser Gly Ser Gly 
                405                 410                 415     


His Thr Thr Asn Thr Ala Ser Ser Ser Ser Ser Cys Leu His Gln Ser 
            420                 425                 430         


Ala Val Arg Lys Ala Ala Tyr Ser His Leu Ser Thr Ser Lys Arg His 
        435                 440                 445             


Ser Ser Ser Gly His Ala Val Glu Leu His Asn Ile Pro Pro Asn Ser 
    450                 455                 460                 


Ala Arg Ser Gln Ser Glu Gly Pro Val Phe Ser Cys Trp Trp Leu Gln 
465                 470                 475                 480 


Phe Arg Asn Ser Lys Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val 
                485                 490                 495     


Asn Leu Leu Glu Asp Trp Gly Pro Cys Thr Glu His Gly Glu His His 
            500                 505                 510         


Ile Arg Ile Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu 
        515                 520                 525             


Val Asp Lys Asn Pro His Asn Thr Thr Glu Ser Arg Leu Val Val Asp 
    530                 535                 540                 


Phe Ser Gln Phe Ser Arg Gly Asn Thr Arg Val Ser Trp Pro Lys Phe 
545                 550                 555                 560 


Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 
                565                 570                 575     


Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu 
            580                 585                 590         


His Pro Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser 
        595                 600                 605             


Arg Tyr Val Ala Arg Leu Ser Ser Asn Ser Arg Ile Ile Asn His Gln 
    610                 615                 620                 


His Gly Thr Met Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr 
625                 630                 635                 640 


Val Ser Leu Leu Leu Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu 
                645                 650                 655     


Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val 
            660                 665                 670         


Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser 
        675                 680                 685             


Val Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asn 
    690                 695                 700                 


Asn Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe 
705                 710                 715                 720 


Thr Ala Val Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro 
                725                 730                 735     


Asn Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val 
            740                 745                 750         


Ile Gly Ser Trp Gly Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile 
        755                 760                 765             


Lys Glu Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 
    770                 775                 780                 


Val Cys Gln Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr 
785                 790                 795                 800 


Gln Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser 
                805                 810                 815     


Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys 
            820                 825                 830         


Gln Tyr Leu Asn Leu Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys 
        835                 840                 845             


Gln Val Phe Ala Asn Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile Gly 
    850                 855                 860                 


His Gln Arg Met Arg Gly Thr Phe Val Ala Pro Leu Pro Ile His Thr 
865                 870                 875                 880 


Ala Gln Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala Lys 
                885                 890                 895     


Leu Ile Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser 
            900                 905                 910         


Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr 
        915                 920                 925             


Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser 
    930                 935                 940                 


Arg Gly Arg Leu Gly Leu Tyr Arg Pro Leu Leu Arg Leu Pro Phe Arg 
945                 950                 955                 960 


Pro Thr Thr Gly Arg Thr Ser Leu Tyr Ala Asp Ser Pro Ser Val Pro 
                965                 970                 975     


Ser His Leu Pro Asp Arg Val His Phe Ala Ser Pro Leu His Val Ala 
            980                 985                 990         


Trp Arg Pro Pro 
        995     


<210>  21
<211>  1023
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core-pol fusion antigen sequence with Ig signal sequence

<400>  21

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Met Asp Ile Asp Pro 
            20                  25                  30          


Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu Ser Phe Leu Pro Ser 
        35                  40                  45              


Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu 
    50                  55                  60                  


Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr 
65                  70                  75                  80  


Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Asn Leu Ala 
                85                  90                  95      


Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala Ser Arg Glu Leu Val 
            100                 105                 110         


Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys Ile Arg Gln Leu Leu 
        115                 120                 125             


Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu 
    130                 135                 140                 


Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 
145                 150                 155                 160 


Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 
                165                 170                 175     


Ala Gly Ala Gly Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 
            180                 185                 190         


Leu Leu Asp Asp Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu 
        195                 200                 205             


Ala Asp Glu Gly Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly 
    210                 215                 220                 


Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr 
225                 230                 235                 240 


Gly Leu Tyr Ser Ser Thr Val Pro Val Phe Asn Pro Glu Trp Gln Thr 
                245                 250                 255     


Pro Ser Phe Pro Asn Ile His Leu Gln Glu Asp Ile Ile Asn Arg Cys 
            260                 265                 270         


Glu Gln Phe Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys 
        275                 280                 285             


Leu Ile Met Pro Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro 
    290                 295                 300                 


Leu Asp Lys Gly Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His 
305                 310                 315                 320 


Tyr Phe Gln Thr Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 
                325                 330                 335     


Leu Tyr Lys Arg Glu Thr Thr Arg Ser Ala Ser Phe Cys Gly Ser Pro 
            340                 345                 350         


Tyr Ser Trp Glu Gln Glu Leu Gln His Gly Arg Leu Val Phe Gln Thr 
        355                 360                 365             


Ser Thr Arg His Gly Asp Glu Ser Phe Cys Gln Gln Ser Ser Gly Ile 
    370                 375                 380                 


Leu Ser Arg Ser Pro Val Gly Pro Cys Leu Gln Ser Gln Leu Arg Lys 
385                 390                 395                 400 


Ser Arg Leu Gly Leu Gln Pro Gln Gln Gly His Leu Ala Arg Arg Gln 
                405                 410                 415     


Gln Gly Arg Ser Gly Ser Ile Arg Ala Arg Val His Pro Thr Thr Arg 
            420                 425                 430         


Arg Pro Phe Gly Val Glu Pro Ser Gly Ser Gly His Thr Thr Asn Thr 
        435                 440                 445             


Ala Ser Ser Ser Ser Ser Cys Leu His Gln Ser Ala Val Arg Lys Ala 
    450                 455                 460                 


Ala Tyr Ser His Leu Ser Thr Ser Lys Arg His Ser Ser Ser Gly His 
465                 470                 475                 480 


Ala Val Glu Leu His Asn Ile Pro Pro Asn Ser Ala Arg Ser Gln Ser 
                485                 490                 495     


Glu Gly Pro Val Phe Ser Cys Trp Trp Leu Gln Phe Arg Asn Ser Lys 
            500                 505                 510         


Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu Asp 
        515                 520                 525             


Trp Gly Pro Cys Thr Glu His Gly Glu His His Ile Arg Ile Pro Arg 
    530                 535                 540                 


Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn Pro 
545                 550                 555                 560 


His Asn Thr Thr Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser 
                565                 570                 575     


Arg Gly Asn Thr Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 
            580                 585                 590         


Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 
        595                 600                 605             


Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala Met 
    610                 615                 620                 


Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala Arg 
625                 630                 635                 640 


Leu Ser Ser Asn Ser Arg Ile Ile Asn His Gln His Gly Thr Met Gln 
                645                 650                 655     


Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu Leu 
            660                 665                 670         


Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro Ile 
        675                 680                 685             


Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 
    690                 695                 700                 


Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala 
705                 710                 715                 720 


Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asn Asn Val Val Leu Gly 
                725                 730                 735     


Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala Val Thr Asn 
            740                 745                 750         


Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg 
        755                 760                 765             


Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly Ser Trp Gly 
    770                 775                 780                 


Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile Lys Glu Cys Phe Arg 
785                 790                 795                 800 


Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 
                805                 810                 815     


Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro 
            820                 825                 830         


Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala Phe Thr 
        835                 840                 845             


Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu Asn Leu 
    850                 855                 860                 


Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys Gln Val Phe Ala Asn 
865                 870                 875                 880 


Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile Gly His Gln Arg Met Arg 
                885                 890                 895     


Gly Thr Phe Val Ala Pro Leu Pro Ile His Thr Ala Gln Leu Leu Ala 
            900                 905                 910         


Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala Lys Leu Ile Gly Thr Asp 
        915                 920                 925             


Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 
    930                 935                 940                 


Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 
945                 950                 955                 960 


Pro Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly 
                965                 970                 975     


Leu Tyr Arg Pro Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly Arg 
            980                 985                 990         


Thr Ser Leu Tyr Ala Asp Ser Pro  Ser Val Pro Ser His  Leu Pro Asp 
        995                 1000                 1005             


Arg Val  His Phe Ala Ser Pro  Leu His Val Ala Trp  Arg Pro Pro 
    1010                 1015                 1020             


<210>  22
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker coding sequence

<400>  22
gccggagctg gc                                                           12


<210>  23
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ApoAI gene fragment

<400>  23
ttggccgtgc tcttcctgac gggtaggtgt cccctaacct agggagccaa ccatcggggg       60

gccttctccc taaatccccg tggcccaccc tcctgggcag aggcagcagg tttctcactg      120

gccccctctc ccccacctcc aagcttggcc tttcggctca gatctcagcc cacagctggc      180

ctgatctggg tctcccctcc caccctcagg gagccaggct cggcatttcg tcgacaagct      240

tagccacc                                                               248


<210>  24
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 polyadenylation signal sequence

<400>  24
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct                                                             130


<210>  25
<211>  587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCMV promoter

<400>  25
cgttgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat       60

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg      120

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata      180

gggactttcc attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta      240

catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc      300

gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca gtacatctac      360

gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga      420

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg      480

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg      540

caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagc                    587


<210>  26
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV S gene

<400>  26
atggagaata tcacctccgg gtttctgggc ccactcctgg tccttcaggc cggattcttc       60

ctgctgactc gaatcctcac cataccccag agcctggaca gctggtggac aagcctgaat      120

tttctgggag gaactcctgt atgcctggga caaaattcac agtcccctac aagtaaccat      180

tcaccgacaa gttgtcctcc catctgtccc ggatacaggt ggatgtgcct gcgaaggttc      240

atcatcttcc tcttcatcct cttgctttgc cttattttcc tcctggttct tctggactat      300

cagggcatgc tgcctgtgtg cccactgata ccaggatcta gtactaccag cacaggcccg      360

tgtaagacct gtacaactcc agcacaaggg actagtatgt tcccctcctg ctgttgtact      420

aagccatcag acggtaattg cacgtgtatc ccaatcccgt cctcctgggc gtttgccaag      480

tttctctggg aatgggcctc agtcagattt tcatggctta gtcttttggt gccgttcgtg      540

cagtggtttg tgggactctc tccgactgtg tggctcagcg tgatctggat gatgtggtac      600

tggggccctt ccctttacaa catactgtct ccattccttc ccctgctgcc aatcttcttt      660

tgcctgtggg tctatattta a                                                681


<210>  27
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV S protein

<400>  27

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Phe Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             


Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  28
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV LM gene

<400>  28
ggtggatgga gctcaaagcc gcggaaaggg atgggtacta acctgtccgt accaaatccc       60

ctgggatttt ttccagacca ccaactcgat cctgcttttg gcgcaaattc caacaatccc      120

gactgggact ttaaccctaa caaggacacc tggcctgatg ccaacaaggt gggggcagga      180

gcctttggtc ccggcttcac cccaccccat ggaggtcttt tgggatggtc accacaggcc      240

cagggcatcc tgaccactgt ccctgctgct ccaccgccag cttctactaa tcgacagagc      300

gggaggcagc cgacccccct gagtcccccc ctgcgggata cccaccctca ggcaatgcag      360

tggaactcaa ctactttcca tcagaccctt caggacccta gagtgcgcgg gctgtacttt      420

cctgctgggg gaagcagtag cgggaccgtt aatccagtac ctacgaccgc ctctcccata      480

tcttctatct ttagtaggac tggtgaccct gctcccaaca tggaaaatat aactagcggc      540

ttcctgggcc cccttctcgt cctgtaa                                          567


<210>  29
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV LM protein

<400>  29

Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
1               5                   10                  15      


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys 
        35                  40                  45              


Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ala Gly Ala Phe Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala 
65                  70                  75                  80  


Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu Arg 
            100                 105                 110         


Asp Thr His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln 
        115                 120                 125             


Thr Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
    130                 135                 140                 


Ser Ser Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro Ile 
145                 150                 155                 160 


Ser Ser Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu Asn 
                165                 170                 175     


Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu 
            180                 185             


<210>  30
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV M protein

<400>  30

Gln Trp Asn Ser Thr Thr Phe His Gln Thr Leu Gln Asp Pro Arg Val 
1               5                   10                  15      


Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn 
            20                  25                  30          


Pro Val Pro Thr Thr Ala Ser Pro Ile Ser Ser Ile Phe Ser Arg Thr 
        35                  40                  45              


Gly Asp Pro Ala Pro Asn Met Glu Asn Ile Thr Ser Gly Phe Leu Gly 
    50                  55                  60                  


Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 
65                  70                  75                  80  


Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 
                85                  90                  95      


Gly Gly Thr Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser 
            100                 105                 110         


Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp 
        115                 120                 125             


Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys 
    130                 135                 140                 


Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 
145                 150                 155                 160 


Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys 
                165                 170                 175     


Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser Met Phe Pro Ser Cys Cys 
            180                 185                 190         


Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser 
        195                 200                 205             


Ser Trp Ala Phe Ala Lys Phe Leu Trp Glu Trp Ala Ser Val Arg Phe 
    210                 215                 220                 


Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 
225                 230                 235                 240 


Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr Trp Gly 
                245                 250                 255     


Pro Ser Leu Tyr Asn Ile Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile 
            260                 265                 270         


Phe Phe Cys Leu Trp Val Tyr Ile 
        275                 280 


<210>  31
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV L protein

<400>  31

Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
1               5                   10                  15      


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys 
        35                  40                  45              


Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ala Gly Ala Phe Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala 
65                  70                  75                  80  


Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu Arg 
            100                 105                 110         


Asp Thr His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln 
        115                 120                 125             


Thr Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
    130                 135                 140                 


Ser Ser Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro Ile 
145                 150                 155                 160 


Ser Ser Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu Asn 
                165                 170                 175     


Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 
            180                 185                 190         


Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 
        195                 200                 205             


Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Pro Val Cys Leu Gly Gln 
    210                 215                 220                 


Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro 
225                 230                 235                 240 


Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 
                245                 250                 255     


Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp 
            260                 265                 270         


Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr 
        275                 280                 285             


Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Thr 
    290                 295                 300                 


Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys 
305                 310                 315                 320 


Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Phe Leu Trp 
                325                 330                 335     


Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 
            340                 345                 350         


Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 
        355                 360                 365             


Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser Pro 
    370                 375                 380                 


Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
385                 390                 395                 


