                         SEQUENCE LISTING

<110>  JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
 
<120>  RECOMBINANT INTERLEUKIN 12 CONSTRUCT AND USES THEREOF

<130>  065814.11191/5WO1

<150>  EP19180939.1
<151>  2019-06-18

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human p40 subunit

<400>  1

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  2
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human p35 subunit

<400>  2

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KE linker

<400>  3

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNA-binding protein 3 IRES

<400>  4

Phe Ile Ile Ser Ser Ser Arg 
1               5           


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMDV 2A peptide

<400>  5

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  6
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  translational coupling spacer

<400>  6
tgatg                                                                    5


<210>  7
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p40 subunit

<400>  7

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210>  8
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse p35 subunit

<400>  8

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210>  9
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus p40 subunit

<400>  9

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Gly Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Ala Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Val Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asn Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Ile Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Ile Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Phe Ser Val Gln Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus p35 subunit

<400>  10

Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Thr Ala 
1               5                   10                  15      


Thr Gly Leu His Pro Ala Ala Arg Pro Glu Pro Leu Gln Cys Arg Leu 
            20                  25                  30          


Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu 
        35                  40                  45              


Leu Asp Tyr Leu Ser Leu Ala Arg Asn Leu Ser Val Ala Thr Pro Gly 
    50                  55                  60                  


Pro Glu Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Lys Ala 
65                  70                  75                  80  


Ala Ser Asn Thr Leu Gln Lys Ala Arg Gln Ile Leu Glu Phe Tyr Pro 
                85                  90                  95      


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
            100                 105                 110         


Ser Thr Val Asp Ala Cys Leu Pro Leu Glu Leu Ile Lys Asn Glu Ser 
        115                 120                 125             


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
    130                 135                 140                 


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Arg Ser Ile 
145                 150                 155                 160 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
                165                 170                 175     


Lys Leu Leu Arg Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Ile 
            180                 185                 190         


Leu Gly Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
        195                 200                 205             


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
    210                 215                 220                 


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
225                 230                 235                 240 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250         


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human p40 signal peptide

<400>  11

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala 
            20          


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p40 signal peptide

<400>  12

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala 
            20          


<210>  13
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus p40 signal peptide

<400>  13

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Met Ala 
            20          


<210>  14
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nhe-p40 oligonucleotide

<400>  14
cctgccgcta gcaccatgtg tcaccagcag ttggtc                                 36


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Xho-p40 oligonucleotide

<400>  15
ctggatctcg agctaactgc agggcacaga tgc                                    33


<210>  16
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nhe-p35 oligonucleotide

<400>  16
gggacagcta gcaccatgtg gccccctggg tcagcct                                37


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Xho-p35 oligonucleotide

<400>  17
ggacctctcg agttaggaag cattcagata gctcatc                                37


<210>  18
<211>  584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCMV promoter sequence

<400>  18
tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc       60

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc      120

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      180

actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt ggcagtacat      240

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      300

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      360

ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag      420

cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt      480

tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa      540

atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagc                       584


<210>  19
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGH polyadenylation signal sequence

<400>  19
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  20
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bla promoter sequence

<400>  20
acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa       60

ccctgataaa tgcttcaata atattgaaaa aggaagagt                              99


<210>  21
<211>  671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC ori sequenc

<400>  21
cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc       60

ttgcaaacaa aaaaaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca t                                                           671


<210>  22
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan R gene

<400>  22
atgattgagc aagatggtct tcacgctggc tcgccagctg cgtgggtgga acgcctgttt       60

ggttatgatt gggcgcagca gactattgga tgttccgacg cggctgtatt tcggctgtct      120

gctcagggtc gccccgtgct gtttgtgaag acggatttgt ctggcgcatt aaatgagtta      180

caggacgagg cggctcgtct gagttggttg gccaccaccg gcgtgccctg cgccgcagtg      240

ctggatgtcg tgacagaagc aggccgcgat tggctccttc tcggcgaagt gccgggccag      300

gacctgctca gcagccactt ggcaccggca gaaaaagttt ctatcatggc cgacgccatg      360

cgtcgtcttc acactctcga tccggccacg tgcccctttg accaccaggc caagcatcgt      420

attgaacgtg cgcgtactcg gatggaagca ggtttagtag accaggacga tttggatgag      480

gaacatcaag gcctggcccc ggctgaactg tttgcgcgct taaaagcgtc gatgccagat      540

ggcgaagatt tggtagtcac ccatggagat gcgtgtttgc caaacatcat ggttgaaaat      600

ggccgcttct caggctttat tgactgtggg cgcctgggtg ttgccgaccg ctatcaagat      660

attgcgctcg caactcgtga catcgctgaa gagctgggcg gagaatgggc tgaccgtttc      720

ctggtactgt atggcattgc agcgcccgat tcccaacgca tcgcatttta tcgtctgctg      780

gatgagtttt tctaa                                                       795


<210>  23
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kan R protein

<400>  23

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  24
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human p40-KE-p35 fusion protein

<400>  24

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe 
305                 310                 315                 320 


Arg Ser Leu Asp Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
                325                 330                 335     


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
            340                 345                 350         


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
        355                 360                 365             


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
    370                 375                 380                 


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
385                 390                 395                 400 


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
                405                 410                 415     


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
        435                 440                 445             


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
465                 470                 475                 480 


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
            500                 505                 510         


Arg Val Met Ser Tyr Leu Asn Ala Ser 
        515                 520     


<210>  25
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p40-KE-p35 fusion protein

<400>  25

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Lys Glu Ser Gly Ser Val Ser 
305                 310                 315                 320 


Ser Glu Gln Leu Ala Gln Phe Arg Ser Leu Asp Arg Val Ile Pro Val 
                325                 330                 335     


Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr 
            340                 345                 350         


Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser 
        355                 360                 365             


Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr 
    370                 375                 380                 


Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser 
385                 390                 395                 400 


Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu 
                405                 410                 415     


Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile 
            420                 425                 430         


Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala 
        435                 440                 445             


Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met 
    450                 455                 460                 


Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu 
465                 470                 475                 480 


Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val 
                485                 490                 495     


Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val 
            500                 505                 510         


Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
        515                 520                 


<210>  26
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus p40-KE-p35 fusion protein

<400>  26

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Gly Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Ala Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Val Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asn Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Ile Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Ile Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Phe Ser Val Gln Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe 
305                 310                 315                 320 


Arg Ser Leu Asp Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser 
                325                 330                 335     


Pro Ala Thr Ala Thr Gly Leu His Pro Ala Ala Arg Pro Glu Pro Leu 
            340                 345                 350         


Gln Cys Arg Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala 
        355                 360                 365             


Thr Leu Val Leu Leu Asp Tyr Leu Ser Leu Ala Arg Asn Leu Ser Val 
    370                 375                 380                 


Ala Thr Pro Gly Pro Glu Met Phe Pro Cys Leu His His Ser Gln Asn 
385                 390                 395                 400 


Leu Leu Lys Ala Ala Ser Asn Thr Leu Gln Lys Ala Arg Gln Ile Leu 
                405                 410                 415     


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
            420                 425                 430         


Lys Asp Lys Thr Ser Thr Val Asp Ala Cys Leu Pro Leu Glu Leu Ile 
        435                 440                 445             


Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn 
    450                 455                 460                 


Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys 
465                 470                 475                 480 


Leu Arg Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys 
                485                 490                 495     


Thr Met Asn Ala Lys Leu Leu Arg Asp Pro Lys Arg Gln Ile Phe Leu 
            500                 505                 510         


Asp Gln Asn Ile Leu Gly Val Ile Asp Glu Leu Met Gln Ala Leu Asn 
        515                 520                 525             


Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp 
    530                 535                 540                 


Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg 
545                 550                 555                 560 


Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                565                 570                 575     


<210>  27
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human p40-KE-p35 fusion

<400>  27
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtaa agaatctggc tcagtaagct cagagcaact ggcgcagttt      960

cgtagtctgg atagaaacct ccccgtggcc actccagacc caggaatgtt cccatgcctt     1020

caccactccc aaaacctgct gagggccgtc agcaacatgc tccagaaggc cagacaaact     1080

ctagaatttt acccttgcac ttctgaagag attgatcatg aagatatcac aaaagataaa     1140

accagcacag tggaggcctg tttaccattg gaattaacca agaatgagag ttgcctaaat     1200

tccagagaga cctctttcat aactaatggg agttgcctgg cctccagaaa gacctctttt     1260

atgatggccc tgtgccttag tagtatttat gaagacttga agatgtacca ggtggagttc     1320

aagaccatga atgcaaagct tctgatggat cctaagaggc agatctttct agatcaaaac     1380

atgctggcag ttattgatga gctgatgcag gccctgaatt tcaacagtga gactgtgcca     1440

caaaaatcct cccttgaaga accggatttt tataaaacta aaatcaagct ctgcatactt     1500

cttcatgctt tcagaattcg ggcagtgact attgatagag tgatgagcta tctgaatgct     1560

tcctaa                                                                1566


<210>  28
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse p40-KE-p35 fusion

<400>  28
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctca      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatcca aagaatctgg atccgtaagc      960

tcagagcaac tggcgcagtt tcgtagtctg gatagggtca ttccagtctc tggacctgcc     1020

aggtgtctta gccagtcccg aaacctgctg aagaccacag atgacatggt gaagacggcc     1080

agagaaaagc ttaaacatta ttcctgcact gctgaagaca tcgatcatga agacatcaca     1140

cgggaccaaa ccagcacatt gaagacctgt ttaccactgg aactacacaa gaacgagagt     1200

tgcctggcta ctagagagac ttcttccaca acaagaggga gctgcctgcc cccacagaag     1260

acgtctttga tgatgaccct gtgccttggt agcatctatg aggacttgaa gatgtaccag     1320

acagagttcc aggccatcaa cgcagcactt cagaatcaca accatcagca gatcattcta     1380

gacaagggca tgctggtggc catcgatgag ctgatgcagt ctctgaatca taatggcgag     1440

actctgcgcc agaaacctcc tgtgggagaa gcagaccctt acagagtgaa aatgaagctc     1500

tgcatcctgc ttcacgcctt cagcacccgc gtcgtgacca tcaacagggt gatgggctat     1560

ctgagctccg cctaa                                                      1575


<210>  29
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cynomolgus p40-KE-p35 fusion

<400>  29
atctgggagc tgaagaagga cgtgtatgtt gtggagctcg actggtaccc agacgcccct       60

ggggaaatgg tggtgttgac atgcgacact cccgaagagg atggtattac ctggactctg      120

gatcagtcag gcgaggttct cggtagcggc aaaaccttga caattcaagt gaaagagttt      180

ggtgatgccg gtcagtacac ctgtcataag ggtggagagg cattgagtca ctctttgttg      240

ttgctgcata agaaggaaga tggaatttgg tctactgatg tcctcaaaga ccagaaagaa      300

ccaaagaaca aaacatttct tcgctgtgaa gctaaaaact attccggtcg gtttacgtgt      360

tggtggctca caactatctc tactgatctg accttttctg tgaaaagcag ccggggttcc      420

tccaatcccc aaggtgttac atgtggagct gtcaccctgt ctgccgagag agtccgcggc      480

gacaataaag aatacgagta ttccgtggag tgccaggaag atagcgcatg tcccgcagct      540

gaagagagac tccccatcga ggtgatggtg gacgccatcc acaaactcaa atatgaaaac      600

tacacaagca gtttcttcat tagggacata attaagcctg atcccccaaa gaacctccaa      660

ctgaaaccct tgaaaaactc cagacaggtg gaggtgagct gggaatatcc agacacctgg      720

tcaactcctc atagctattt ctctctgacc ttttgcatcc aagtacaggg caagtccaag      780

agggagaaga aagatagaat tttcaccgac aaaacgtctg caacggtcat ctgtaggaaa      840

aatgctagtt tttccgtaca ggctcaggat agatattaca gtagcagttg gtcagagtgg      900

gcaagtgtgc catgttccaa agagagtgga tccgttagct ccgagcaact cgcccagttt      960

cggtctctag actggccccc aggttctgct agtcagccac ctccatcccc cgccacagct     1020

accggcctgc accccgctgc taggcctgag cctctgcagt gtaggctcag tatgtgcccc     1080

gcacgcagcc ttctcctcgt ggctacactg gtactgttgg attatctgag tctggcccgg     1140

aatctgagtg ttgctacacc agggcctgag atgtttccat gcctccatca tagtcagaac     1200

ctgcttaaag ccgcctctaa taccctgcag aaagctagac aaattctgga attttatcct     1260

tgcaccagtg aggagattga tcacgaggat attacaaaag ataagacctc aactgtcgat     1320

gcttgtctgc cacttgagtt gattaaaaac gagagctgcc ttaattccag agagactagc     1380

ttcataacta atggctcctg cctcgccagc aggaagacta gttttatgat ggcactgtgc     1440

ctgcggagta tctatgagga tcttaaaatg tatcaggtgg agtttaagac aatgaacgcc     1500

aaactgctta gagatcccaa acgacaaatc tttctcgatc agaacattct cggcgtaatt     1560

gacgagctga tgcaagctct gaattttaat tctgagaccg tcccacagaa atcatccctg     1620

gaagaacctg atttttataa aaccaagatc aagctttgca ttctgcttca cgcatttcgc     1680

atccgagctg tgacgattga tcgggtgatg tcatacctga atgcatcttg atag           1734


