                         SEQUENCE LISTING

<110>  JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
 
<120>  COMBINATION OF RECOMBINANT INTERLEUKIN 12 CONSTRUCT AND 
	HEPATITIS B VIRUS (HBV) VACCINES

<130>  065814.11190/5WO2

<150>  EP19180980.5
<151>  2019-06-18

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human p40 subunit

<400>  1

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  2
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human p35 subunit

<400>  2

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KE linker

<400>  3

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNA-binding protein 3 IRES

<400>  4

Phe Ile Ile Ser Ser Ser Arg 
1               5           


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMDV 2A peptide

<400>  5

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  6
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  translational coupling spacer

<400>  6
tgatg                                                                    5


<210>  7
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p40 subunit

<400>  7

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210>  8
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p35 subunit

<400>  8

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210>  9
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus p40 subunit

<400>  9

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Gly Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Ala Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Val Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asn Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Ile Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Ile Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Phe Ser Val Gln Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus p35 subunit

<400>  10

Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Thr Ala 
1               5                   10                  15      


Thr Gly Leu His Pro Ala Ala Arg Pro Glu Pro Leu Gln Cys Arg Leu 
            20                  25                  30          


Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu 
        35                  40                  45              


Leu Asp Tyr Leu Ser Leu Ala Arg Asn Leu Ser Val Ala Thr Pro Gly 
    50                  55                  60                  


Pro Glu Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Lys Ala 
65                  70                  75                  80  


Ala Ser Asn Thr Leu Gln Lys Ala Arg Gln Ile Leu Glu Phe Tyr Pro 
                85                  90                  95      


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
            100                 105                 110         


Ser Thr Val Asp Ala Cys Leu Pro Leu Glu Leu Ile Lys Asn Glu Ser 
        115                 120                 125             


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
    130                 135                 140                 


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Arg Ser Ile 
145                 150                 155                 160 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
                165                 170                 175     


Lys Leu Leu Arg Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Ile 
            180                 185                 190         


Leu Gly Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
        195                 200                 205             


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
    210                 215                 220                 


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
225                 230                 235                 240 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250         


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human p40 signal peptide

<400>  11

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala 
            20          


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p40 signal peptide

<400>  12

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala 
            20          


<210>  13
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus p40 signal peptide

<400>  13

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Met Ala 
            20          


<210>  14
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nhe-P40 oligonucleotide

<400>  14
cctgccgcta gcaccatgtg tcaccagcag ttggtc                                 36


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Xho-p40 oligonucleotide

<400>  15
ctggatctcg agctaactgc agggcacaga tgc                                    33


<210>  16
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nhe-p35 oligonucleotide

<400>  16
gggacagcta gcaccatgtg gccccctggg tcagcct                                37


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Xho-p35 oligonucleotide

<400>  17
ggacctctcg agttaggaag cattcagata gctcatc                                37


<210>  18
<211>  584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCMV promoter sequence

<400>  18
tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc       60

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc      120

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      180

actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt ggcagtacat      240

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      300

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      360

ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag      420

cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt      480

tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa      540

atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagc                       584


<210>  19
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGH polyadenylation signal sequence

<400>  19
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  20
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bla promoter sequence

<400>  20
acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa       60

ccctgataaa tgcttcaata atattgaaaa aggaagagt                              99


<210>  21
<211>  671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC ori sequenc

<400>  21
cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc       60

ttgcaaacaa aaaaaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact      120

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg      180

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg      240

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac      300

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca      360

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga      420

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc      480

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct      540

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg      600

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct      660

tttgctcaca t                                                           671


<210>  22
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan R gene

<400>  22
atgattgagc aagatggtct tcacgctggc tcgccagctg cgtgggtgga acgcctgttt       60

ggttatgatt gggcgcagca gactattgga tgttccgacg cggctgtatt tcggctgtct      120

gctcagggtc gccccgtgct gtttgtgaag acggatttgt ctggcgcatt aaatgagtta      180

caggacgagg cggctcgtct gagttggttg gccaccaccg gcgtgccctg cgccgcagtg      240

ctggatgtcg tgacagaagc aggccgcgat tggctccttc tcggcgaagt gccgggccag      300

gacctgctca gcagccactt ggcaccggca gaaaaagttt ctatcatggc cgacgccatg      360

cgtcgtcttc acactctcga tccggccacg tgcccctttg accaccaggc caagcatcgt      420

attgaacgtg cgcgtactcg gatggaagca ggtttagtag accaggacga tttggatgag      480

gaacatcaag gcctggcccc ggctgaactg tttgcgcgct taaaagcgtc gatgccagat      540

ggcgaagatt tggtagtcac ccatggagat gcgtgtttgc caaacatcat ggttgaaaat      600

ggccgcttct caggctttat tgactgtggg cgcctgggtg ttgccgaccg ctatcaagat      660

attgcgctcg caactcgtga catcgctgaa gagctgggcg gagaatgggc tgaccgtttc      720

ctggtactgt atggcattgc agcgcccgat tcccaacgca tcgcatttta tcgtctgctg      780

gatgagtttt tctaa                                                       795


<210>  23
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kan R protein

<400>  23

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  24
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human p40-KE-p35 fusion protein

<400>  24

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe 
305                 310                 315                 320 


Arg Ser Leu Asp Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
                325                 330                 335     


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
            340                 345                 350         


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
        355                 360                 365             


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
    370                 375                 380                 


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
385                 390                 395                 400 


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
                405                 410                 415     


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
        435                 440                 445             


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
465                 470                 475                 480 


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
            500                 505                 510         


Arg Val Met Ser Tyr Leu Asn Ala Ser 
        515                 520     


<210>  25
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse p40-KE-p35 fusion protein

<400>  25

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Lys Glu Ser Gly Ser Val Ser 
305                 310                 315                 320 


Ser Glu Gln Leu Ala Gln Phe Arg Ser Leu Asp Arg Val Ile Pro Val 
                325                 330                 335     


Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr 
            340                 345                 350         


Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser 
        355                 360                 365             


Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr 
    370                 375                 380                 


Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser 
385                 390                 395                 400 


Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu 
                405                 410                 415     


Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile 
            420                 425                 430         


Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala 
        435                 440                 445             


Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met 
    450                 455                 460                 


Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu 
465                 470                 475                 480 


Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val 
                485                 490                 495     


Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val 
            500                 505                 510         


Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
        515                 520                 


<210>  26
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus p40-KE-p35 fusion protein

<400>  26

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Gly Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Ala Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Val Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asn Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Ile Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Ile Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Phe Ser Val Gln Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe 
305                 310                 315                 320 


Arg Ser Leu Asp Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser 
                325                 330                 335     


Pro Ala Thr Ala Thr Gly Leu His Pro Ala Ala Arg Pro Glu Pro Leu 
            340                 345                 350         


Gln Cys Arg Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala 
        355                 360                 365             


Thr Leu Val Leu Leu Asp Tyr Leu Ser Leu Ala Arg Asn Leu Ser Val 
    370                 375                 380                 


Ala Thr Pro Gly Pro Glu Met Phe Pro Cys Leu His His Ser Gln Asn 
385                 390                 395                 400 


Leu Leu Lys Ala Ala Ser Asn Thr Leu Gln Lys Ala Arg Gln Ile Leu 
                405                 410                 415     


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
            420                 425                 430         


Lys Asp Lys Thr Ser Thr Val Asp Ala Cys Leu Pro Leu Glu Leu Ile 
        435                 440                 445             


Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn 
    450                 455                 460                 


Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys 
465                 470                 475                 480 


Leu Arg Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys 
                485                 490                 495     


Thr Met Asn Ala Lys Leu Leu Arg Asp Pro Lys Arg Gln Ile Phe Leu 
            500                 505                 510         


Asp Gln Asn Ile Leu Gly Val Ile Asp Glu Leu Met Gln Ala Leu Asn 
        515                 520                 525             


Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp 
    530                 535                 540                 


Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg 
545                 550                 555                 560 


Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                565                 570                 575     


<210>  27
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human p40-KE-p35 fusion

<400>  27
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtaa agaatctggc tcagtaagct cagagcaact ggcgcagttt      960

cgtagtctgg atagaaacct ccccgtggcc actccagacc caggaatgtt cccatgcctt     1020

caccactccc aaaacctgct gagggccgtc agcaacatgc tccagaaggc cagacaaact     1080

ctagaatttt acccttgcac ttctgaagag attgatcatg aagatatcac aaaagataaa     1140

accagcacag tggaggcctg tttaccattg gaattaacca agaatgagag ttgcctaaat     1200

tccagagaga cctctttcat aactaatggg agttgcctgg cctccagaaa gacctctttt     1260

atgatggccc tgtgccttag tagtatttat gaagacttga agatgtacca ggtggagttc     1320

aagaccatga atgcaaagct tctgatggat cctaagaggc agatctttct agatcaaaac     1380

atgctggcag ttattgatga gctgatgcag gccctgaatt tcaacagtga gactgtgcca     1440

caaaaatcct cccttgaaga accggatttt tataaaacta aaatcaagct ctgcatactt     1500

cttcatgctt tcagaattcg ggcagtgact attgatagag tgatgagcta tctgaatgct     1560

tcctaa                                                                1566


<210>  28
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse p40-KE-p35 fusion

<400>  28
atgtgggagc tggagaaaga cgtttatgtt gtagaggtgg actggactcc cgatgcccct       60

ggagaaacag tgaacctcac ctgtgacacg cctgaagaag atgacatcac ctggacctca      120

gaccagagac atggagtcat aggctctgga aagaccctga ccatcactgt caaagagttt      180

ctagatgctg gccagtacac ctgccacaaa ggaggcgaga ctctgagcca ctcacatctg      240

ctgctccaca agaaggaaaa tggaatttgg tccactgaaa ttttaaaaaa tttcaaaaac      300

aagactttcc tgaagtgtga agcaccaaat tactccggac ggttcacgtg ctcatggctg      360

gtgcaaagaa acatggactt gaagttcaac atcaagagca gtagcagttc ccctgactct      420

cgggcagtga catgtggaat ggcgtctctg tctgcagaga aggtcacact ggaccaaagg      480

gactatgaga agtattcagt gtcctgccag gaggatgtca cctgcccaac tgccgaggag      540

accctgccca ttgaactggc gttggaagca cggcagcaga ataaatatga gaactacagc      600

accagcttct tcatcaggga catcatcaaa ccagacccgc ccaagaactt gcagatgaag      660

cctttgaaga actcacaggt ggaggtcagc tgggagtacc ctgactcctg gagcactccc      720

cattcctact tctccctcaa gttctttgtt cgaatccagc gcaagaaaga aaagatgaag      780

gagacagagg aggggtgtaa ccagaaaggt gcgttcctcg tagagaagac atctaccgaa      840

gtccaatgca aaggcgggaa tgtctgcgtg caagctcagg atcgctatta caattcctca      900

tgcagcaagt gggcatgtgt tccctgcagg gtccgatcca aagaatctgg atccgtaagc      960

tcagagcaac tggcgcagtt tcgtagtctg gatagggtca ttccagtctc tggacctgcc     1020

aggtgtctta gccagtcccg aaacctgctg aagaccacag atgacatggt gaagacggcc     1080

agagaaaagc ttaaacatta ttcctgcact gctgaagaca tcgatcatga agacatcaca     1140

cgggaccaaa ccagcacatt gaagacctgt ttaccactgg aactacacaa gaacgagagt     1200

tgcctggcta ctagagagac ttcttccaca acaagaggga gctgcctgcc cccacagaag     1260

acgtctttga tgatgaccct gtgccttggt agcatctatg aggacttgaa gatgtaccag     1320

acagagttcc aggccatcaa cgcagcactt cagaatcaca accatcagca gatcattcta     1380

gacaagggca tgctggtggc catcgatgag ctgatgcagt ctctgaatca taatggcgag     1440

actctgcgcc agaaacctcc tgtgggagaa gcagaccctt acagagtgaa aatgaagctc     1500

tgcatcctgc ttcacgcctt cagcacccgc gtcgtgacca tcaacagggt gatgggctat     1560

ctgagctccg cctaa                                                      1575


<210>  29
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cynomolgus p40-KE-p35 fusion

<400>  29
atctgggagc tgaagaagga cgtgtatgtt gtggagctcg actggtaccc agacgcccct       60

ggggaaatgg tggtgttgac atgcgacact cccgaagagg atggtattac ctggactctg      120

gatcagtcag gcgaggttct cggtagcggc aaaaccttga caattcaagt gaaagagttt      180

ggtgatgccg gtcagtacac ctgtcataag ggtggagagg cattgagtca ctctttgttg      240

ttgctgcata agaaggaaga tggaatttgg tctactgatg tcctcaaaga ccagaaagaa      300

ccaaagaaca aaacatttct tcgctgtgaa gctaaaaact attccggtcg gtttacgtgt      360

tggtggctca caactatctc tactgatctg accttttctg tgaaaagcag ccggggttcc      420

tccaatcccc aaggtgttac atgtggagct gtcaccctgt ctgccgagag agtccgcggc      480

gacaataaag aatacgagta ttccgtggag tgccaggaag atagcgcatg tcccgcagct      540

gaagagagac tccccatcga ggtgatggtg gacgccatcc acaaactcaa atatgaaaac      600

tacacaagca gtttcttcat tagggacata attaagcctg atcccccaaa gaacctccaa      660

ctgaaaccct tgaaaaactc cagacaggtg gaggtgagct gggaatatcc agacacctgg      720

tcaactcctc atagctattt ctctctgacc ttttgcatcc aagtacaggg caagtccaag      780

agggagaaga aagatagaat tttcaccgac aaaacgtctg caacggtcat ctgtaggaaa      840

aatgctagtt tttccgtaca ggctcaggat agatattaca gtagcagttg gtcagagtgg      900

gcaagtgtgc catgttccaa agagagtgga tccgttagct ccgagcaact cgcccagttt      960

cggtctctag actggccccc aggttctgct agtcagccac ctccatcccc cgccacagct     1020

accggcctgc accccgctgc taggcctgag cctctgcagt gtaggctcag tatgtgcccc     1080

gcacgcagcc ttctcctcgt ggctacactg gtactgttgg attatctgag tctggcccgg     1140

aatctgagtg ttgctacacc agggcctgag atgtttccat gcctccatca tagtcagaac     1200

ctgcttaaag ccgcctctaa taccctgcag aaagctagac aaattctgga attttatcct     1260

tgcaccagtg aggagattga tcacgaggat attacaaaag ataagacctc aactgtcgat     1320

gcttgtctgc cacttgagtt gattaaaaac gagagctgcc ttaattccag agagactagc     1380

ttcataacta atggctcctg cctcgccagc aggaagacta gttttatgat ggcactgtgc     1440

ctgcggagta tctatgagga tcttaaaatg tatcaggtgg agtttaagac aatgaacgcc     1500

aaactgctta gagatcccaa acgacaaatc tttctcgatc agaacattct cggcgtaatt     1560

gacgagctga tgcaagctct gaattttaat tctgagaccg tcccacagaa atcatccctg     1620

gaagaacctg atttttataa aaccaagatc aagctttgca ttctgcttca cgcatttcgc     1680

atccgagctg tgacgattga tcgggtgatg tcatacctga atgcatcttg atag           1734


<210>  30
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen gene

<400>  30
gacatcgacc cttacaagga gttcggcgcc agcgtggaac tgctgtcttt tctgcccagt       60

gatttctttc cttccattcg agacctgctg gataccgcct ctgctctgta tcgggaagcc      120

ctggagagcc cagaacactg ctccccacac cataccgctc tgcgacaggc aatcctgtgc      180

tggggggagc tgatgaacct ggccacatgg gtgggatcga atctggagga ccccgcttca      240

cgggaactgg tggtcagcta cgtgaacgtc aatatgggcc tgaaaatccg ccagctgctg      300

tggttccata ttagctgcct gacttttgga cgagagaccg tgctggaata cctggtgtcc      360

ttcggcgtct ggattcgcac tccccctgct tatcgaccac ccaacgcacc aattctgtcc      420

accctgcccg agaccacagt ggtc                                             444


<210>  31
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen

<400>  31

Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu Ser 
1               5                   10                  15      


Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp Thr 
            20                  25                  30          


Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser 
        35                  40                  45              


Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 
    50                  55                  60                  


Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala Ser 
65                  70                  75                  80  


Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys Ile 
                85                  90                  95      


Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu 
            100                 105                 110         


Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro 
        115                 120                 125             


Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu 
    130                 135                 140                 


Thr Thr Val Val 
145             


<210>  32
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV pol antigen gene

<400>  32
atgcccctgt cttaccagca ctttagaaag cttctgctgc tggacgatga agccgggcct       60

ctggaggaag agctgccaag gctggcagac gaggggctga accggagagt ggccgaagat      120

ctgaatctgg gaaacctgaa cgtgagcatc ccttggactc ataaagtcgg caacttcacc      180

gggctgtaca gctccacagt gcctgtcttc aatccagagt ggcagacacc atcctttccc      240

aacattcacc tgcaggagga catcattaat agatgcgaac agttcgtggg acctctgaca      300

gtcaacgaaa agaggcgcct gaaactgatc atgcctgcca ggttttaccc aaatgtgact      360

aagtatctgc cactggataa gggcatcaag ccttactatc cagagcacct ggtgaaccat      420

tacttccaga ctagacacta tctgcatacc ctgtggaagg ccggaatcct gtacaaacga      480

gaaactaccc ggagtgcttc attttgtggc tccccatatt cttgggaaca ggagctgcag      540

catggcaggc tggtgttcca gaccagcaca cgccacgggg atgagtcctt ttgccagcag      600

tctagtggca tcctgagcag atcccccgtg gggccttgtc tgcagtctca gctgcggaag      660

agtagactgg gactgcagcc acagcaggga cacctggcac gacggcagca gggaaggtct      720

ggcagtatcc gggctagagt gcatcccaca actagaaggc ctttcggcgt cgagccatca      780

ggaagcggcc acaccacaaa caccgcatca agctcctcta gttgcctgca tcagtcagcc      840

gtgagaaagg ccgcttacag ccacctgtcc acatctaaaa ggcactcaag ctccgggcat      900

gctgtggagc tgcacaacat ccctccaaat tctgcacgca gtcagtcaga aggacccgtg      960

ttcagctgct ggtggctgca gtttcggaac tcaaagcctt gcagcgacta ttgtctgagc     1020

catattgtga atctgctgga ggattggggc ccttgtaccg agcacgggga acaccatatc     1080

aggattccac gaacaccagc acgagtgact ggaggggtgt tcctggtgga caagaacccc     1140

cacaatacta ccgagagccg gctggtggtc gatttcagtc agttttcaag aggcaacaca     1200

agggtgtcat ggcccaaatt cgccgtccct aatctgcaga gtctgactaa cctgctgtct     1260

agtaatctga gctggctgtc cctggacgtg tccgcagcct tttaccacct gcctctgcat     1320

ccagctgcaa tgccccatct gctggtgggg tcaagcggac tgagtcgcta cgtcgcccga     1380

ctgtcctcta actcacgcat cattaatcac cagcatggca ccatgcagaa cctgcacgat     1440

agctgttccc ggaatctgta cgtgtctctg ctgctgctgt ataagacatt cggcagaaaa     1500

ctgcacctgt acagccatcc tatcattctg gggtttagga agatcccaat gggagtggga     1560

ctgagcccct tcctgctggc acagtttacc tccgccattt gctctgtggt ccgccgagcc     1620

ttcccacact gtctggcttt ttcctatatg aacaatgtgg tcctgggcgc caaatccgtg     1680

cagcatctgg agtctctgtt cacagctgtc actaactttc tgctgagcct ggggatccac     1740

ctgaacccaa ataagactaa acgctggggg tacagcctga atttcatggg atatgtgatt     1800

ggatcctggg ggaccctgcc acaggagcac atcgtgcaga agatcaagga atgctttcgg     1860

aagctgcccg tcaacagacc tatcgactgg aaagtgtgcc agcggattgt cggactgctg     1920

ggcttcgccg ctccctttac ccagtgcggg tacccagcac tgatgcccct gtatgcctgt     1980

atccagtcta agcaggcttt cacctttagt cctacataca aggcattcct gtgcaaacag     2040

tacctgaacc tgtatccagt ggcaaggcag cgacctggac tgtgccaggt ctttgcaaat     2100

gccactccta ccggctgggg gctggctatc ggacatcagc gaatgcgggg cacattcgtg     2160

gcccccctgc ctattcacac tgctcagctg ctggcagcct gctttgctag atctaggagt     2220

ggagcaaagc tgatcggcac cgacaatagt gtggtcctgt caagaaaata cacatccttc     2280

ccatggctgc tgggatgtgc tgcaaactgg attctgaggg gcaccagctt cgtgtacgtc     2340

ccctcagccc tgaatcctgc tgacgatcca tcccgcgggc gactgggact gtaccgacct     2400

ctgctgagac tgcccttcag gcctacaact ggccggacat ctctgtatgc cgattcacca     2460

agcgtgccct cacacctgcc tgacagagtc cactttgctt cacccctgca cgtcgcttgg     2520

cggcctcca                                                             2529


<210>  33
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV pol antigen

<400>  33

Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu Leu Leu Asp Asp 
1               5                   10                  15      


Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 
            20                  25                  30          


Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 
        35                  40                  45              


Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser 
    50                  55                  60                  


Ser Thr Val Pro Val Phe Asn Pro Glu Trp Gln Thr Pro Ser Phe Pro 
65                  70                  75                  80  


Asn Ile His Leu Gln Glu Asp Ile Ile Asn Arg Cys Glu Gln Phe Val 
                85                  90                  95      


Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile Met Pro 
            100                 105                 110         


Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu Asp Lys Gly 
        115                 120                 125             


Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His Tyr Phe Gln Thr 
    130                 135                 140                 


Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 
145                 150                 155                 160 


Glu Thr Thr Arg Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp Glu 
                165                 170                 175     


Gln Glu Leu Gln His Gly Arg Leu Val Phe Gln Thr Ser Thr Arg His 
            180                 185                 190         


Gly Asp Glu Ser Phe Cys Gln Gln Ser Ser Gly Ile Leu Ser Arg Ser 
        195                 200                 205             


Pro Val Gly Pro Cys Leu Gln Ser Gln Leu Arg Lys Ser Arg Leu Gly 
    210                 215                 220                 


Leu Gln Pro Gln Gln Gly His Leu Ala Arg Arg Gln Gln Gly Arg Ser 
225                 230                 235                 240 


Gly Ser Ile Arg Ala Arg Val His Pro Thr Thr Arg Arg Pro Phe Gly 
                245                 250                 255     


Val Glu Pro Ser Gly Ser Gly His Thr Thr Asn Thr Ala Ser Ser Ser 
            260                 265                 270         


Ser Ser Cys Leu His Gln Ser Ala Val Arg Lys Ala Ala Tyr Ser His 
        275                 280                 285             


Leu Ser Thr Ser Lys Arg His Ser Ser Ser Gly His Ala Val Glu Leu 
    290                 295                 300                 


His Asn Ile Pro Pro Asn Ser Ala Arg Ser Gln Ser Glu Gly Pro Val 
305                 310                 315                 320 


Phe Ser Cys Trp Trp Leu Gln Phe Arg Asn Ser Lys Pro Cys Ser Asp 
                325                 330                 335     


Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu Asp Trp Gly Pro Cys 
            340                 345                 350         


Thr Glu His Gly Glu His His Ile Arg Ile Pro Arg Thr Pro Ala Arg 
        355                 360                 365             


Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr 
    370                 375                 380                 


Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asn Thr 
385                 390                 395                 400 


Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr 
                405                 410                 415     


Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala 
            420                 425                 430         


Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala Met Pro His Leu Leu 
        435                 440                 445             


Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala Arg Leu Ser Ser Asn 
    450                 455                 460                 


Ser Arg Ile Ile Asn His Gln His Gly Thr Met Gln Asn Leu His Asp 
465                 470                 475                 480 


Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu Leu Leu Tyr Lys Thr 
                485                 490                 495     


Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe 
            500                 505                 510         


Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln 
        515                 520                 525             


Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala Phe Pro His Cys 
    530                 535                 540                 


Leu Ala Phe Ser Tyr Met Asn Asn Val Val Leu Gly Ala Lys Ser Val 
545                 550                 555                 560 


Gln His Leu Glu Ser Leu Phe Thr Ala Val Thr Asn Phe Leu Leu Ser 
                565                 570                 575     


Leu Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr Ser 
            580                 585                 590         


Leu Asn Phe Met Gly Tyr Val Ile Gly Ser Trp Gly Thr Leu Pro Gln 
        595                 600                 605             


Glu His Ile Val Gln Lys Ile Lys Glu Cys Phe Arg Lys Leu Pro Val 
    610                 615                 620                 


Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu 
625                 630                 635                 640 


Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met Pro 
                645                 650                 655     


Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala Phe Thr Phe Ser Pro Thr 
            660                 665                 670         


Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu Asn Leu Tyr Pro Val Ala 
        675                 680                 685             


Arg Gln Arg Pro Gly Leu Cys Gln Val Phe Ala Asn Ala Thr Pro Thr 
    690                 695                 700                 


Gly Trp Gly Leu Ala Ile Gly His Gln Arg Met Arg Gly Thr Phe Val 
705                 710                 715                 720 


Ala Pro Leu Pro Ile His Thr Ala Gln Leu Leu Ala Ala Cys Phe Ala 
                725                 730                 735     


Arg Ser Arg Ser Gly Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val 
            740                 745                 750         


Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala 
        755                 760                 765             


Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu 
    770                 775                 780                 


Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu Tyr Arg Pro 
785                 790                 795                 800 


Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly Arg Thr Ser Leu Tyr 
                805                 810                 815     


Ala Asp Ser Pro Ser Val Pro Ser His Leu Pro Asp Arg Val His Phe 
            820                 825                 830         


Ala Ser Pro Leu His Val Ala Trp Arg Pro Pro 
        835                 840             


<210>  34
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cystatin S signal peptide coding sequence

<400>  34
atggctcgac ctctgtgtac cctgctactc ctgatggcta ccctggctgg agctctggcc       60

agc                                                                     63


<210>  35
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cystatin S signal peptide sequence

<400>  35

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Ser 
            20      


<210>  36
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  triple enhancer regulatory sequence

<400>  36
ggctcgcatc tctccttcac gcgcccgccg ccctacctga ggccgccatc cacgccggtt       60

gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga actgcgtccg ccgtctaggt      120

aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg ctcccttgga gcctacctag      180

actcagccgg ctctccacgc tttgcctgac cctgcttgct caactctagt tctctcgtta      240

acttaatgag acagatagaa actggtcttg tagaaacaga gtagtcgcct gcttttctgc      300

caggtgctga cttctctccc ctgggctttt ttctttttct caggttgaaa agaagaagac      360

gaagaagacg aagaagac                                                    378


<210>  37
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen

<400>  37

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val 
145                 


<210>  38
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV truncated core antigen gene

<400>  38
atggacatcg acccttacaa ggagttcggc gccagcgtgg aactgctgtc ttttctgccc       60

agtgatttct ttccttccat tcgagacctg ctggataccg cctctgctct gtatcgggaa      120

gccctggaga gcccagaaca ctgctcccca caccataccg ctctgcgaca ggcaatcctg      180

tgctgggggg agctgatgaa cctggccaca tgggtgggat ccaatctgga ggaccccgct      240

tcacgggaac tggtggtcag ctacgtgaac gtcaatatgg gcctgaaaat ccgccagctg      300

ctgtggttcc atattagctg cctgactttt ggacgagaga ccgtgctgga atacctggtg      360

tccttcggcg tctggatccg cactccccct gcttatcgac cacccaacgc accaattctg      420

tccaccctgc ccgagaccac agtggtc                                          447


<210>  39
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV pol antigen gene

<400>  39
atgcccctgt cttaccagca ctttagaaag ctgctgctgc tggacgatga agccgggcct       60

ctggaggaag agctgccaag gctggcagac gaggggctga accggagagt ggccgaagat      120

ctgaatctgg gaaacctgaa cgtgagcatc ccttggactc ataaagtcgg caacttcacc      180

gggctgtaca gctccacagt gcctgtcttc aatccagagt ggcagacacc atcctttccc      240

aacattcacc tgcaggagga catcattaat agatgcgaac agttcgtggg acctctgaca      300

gtcaacgaaa agaggcgcct gaaactgatc atgcctgcca ggttttaccc aaatgtgact      360

aagtatctgc cactggataa gggcatcaag ccttactatc cagagcacct ggtgaaccat      420

tacttccaga ctagacacta tctgcatacc ctgtggaagg ccggaatcct gtacaaacga      480

gaaactaccc ggagtgcttc attttgtggc tccccatatt cttgggaaca ggagctgcag      540

catggcaggc tggtgttcca gaccagcaca cgccacgggg atgagtcctt ttgccagcag      600

tctagtggca tcctgagcag atcccccgtg gggccttgtc tgcagtctca gctgcggaag      660

agtagactgg gactgcagcc acagcaggga cacctggcac gacggcagca gggaaggtct      720

ggcagtatcc gggctagagt gcatcccaca actagaaggc ctttcggcgt cgagccatca      780

ggaagcggcc acaccacaaa caccgcatca agctcctcta gttgcctgca tcagtcagcc      840

gtgagaaagg ccgcttacag ccacctgtcc acatctaaaa ggcactcaag ctccgggcat      900

gctgtggagc tgcacaacat ccctccaaat tctgcacgca gtcagtcaga aggacccgtg      960

ttcagctgct ggtggctgca gtttcggaac tcaaagcctt gcagcgacta ttgtctgagc     1020

catattgtga atctgctgga ggattggggc ccttgtaccg agcacgggga acaccatatc     1080

aggattccac gaacaccagc acgagtgact ggaggggtgt tcctggtgga caagaacccc     1140

cacaatacta ccgagagccg gctggtggtc gatttcagtc agttttcaag aggcaacaca     1200

agggtgtcat ggcccaaatt cgccgtccct aatctgcaga gtctgactaa cctgctgtct     1260

agtaatctga gctggctgtc cctggacgtg tccgcagcct tttaccacct gcctctgcat     1320

ccagctgcaa tgccccatct gctggtgggg tcaagcggac tgagtcgcta cgtcgcccga     1380

ctgtcctcta actcacgcat cattaatcac cagcatggca ccatgcagaa cctgcacgat     1440

agctgttccc ggaatctgta cgtgtctctg ctgctgctgt ataagacatt cggcagaaaa     1500

ctgcacctgt acagccatcc tatcattctg gggtttagga agatcccaat gggagtggga     1560

ctgagcccct tcctgctggc acagtttacc tccgccattt gctctgtggt ccgccgagcc     1620

ttcccacact gtctggcttt ttcctatatg aacaatgtgg tcctgggcgc caaatccgtg     1680

cagcatctgg agtctctgtt cacagctgtc actaactttc tgctgagcct ggggatccac     1740

ctgaacccaa ataagactaa acgctggggg tacagcctga atttcatggg atatgtgatt     1800

ggatcctggg ggaccctgcc acaggagcac atcgtgcaga agatcaagga atgctttcgg     1860

aagctgcccg tcaacagacc tatcgactgg aaagtgtgcc agcggattgt cggactgctg     1920

ggcttcgccg ctccctttac ccagtgcggg tacccagcac tgatgcccct gtatgcctgt     1980

atccagtcta agcaggcttt cacctttagt cctacataca aggcattcct gtgcaaacag     2040

tacctgaacc tgtatccagt ggcaaggcag cgacctggac tgtgccaggt ctttgcaaat     2100

gccactccta ccggctgggg gctggctatc ggacatcagc gaatgcgggg cacattcgtg     2160

gcccccctgc ctattcacac tgctcagctg ctggcagcct gctttgctag atctaggagt     2220

ggagcaaagc tgatcggcac cgacaatagt gtggtcctgt caagaaaata cacatccttc     2280

ccatggctgc tgggatgtgc tgcaaactgg attctgaggg gcaccagctt cgtgtacgtc     2340

ccctcagccc tgaatcctgc tgacgatcca tcccgcgggc gactgggact gtaccgacct     2400

ctgctgagac tgcccttcag gcctacaact ggccggacat ctctgtatgc cgattcacca     2460

agcgtgccct cacacctgcc tgacagagtc cactttgctt cacccctgca cgtcgcttgg     2520

cggcctcca                                                             2529


<210>  40
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker coding sequence

<400>  40
gccggagctg gc                                                           12


<210>  41
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ApoAI gene fragment

<400>  41
ttggccgtgc tcttcctgac gggtaggtgt cccctaacct agggagccaa ccatcggggg       60

gccttctccc taaatccccg tggcccaccc tcctgggcag aggcagcagg tttctcactg      120

gccccctctc ccccacctcc aagcttggcc tttcggctca gatctcagcc cacagctggc      180

ctgatctggg tctcccctcc caccctcagg gagccaggct cggcatttcg tcgacaagct      240

tagccacc                                                               248


<210>  42
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 polyadenylation signal sequence

<400>  42
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct                                                             130


<210>  43
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  immunoglobulin secretion signal coding sequence

<400>  43
atggagttcg gcctgtcttg ggtctttctg gtggcaatcc tgaagggcgt gcagtgtgaa       60

gtgcagctgc tggagtctgg a                                                 81


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin secretion signal sequence

<400>  44

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25          


<210>  45
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core-pol fusion antigen sequence

<400>  45

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Asn Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Glu Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Ala Gly Ala Gly Met Pro Leu Ser Tyr Gln His 
145                 150                 155                 160 


Phe Arg Lys Leu Leu Leu Leu Asp Asp Glu Ala Gly Pro Leu Glu Glu 
                165                 170                 175     


Glu Leu Pro Arg Leu Ala Asp Glu Gly Leu Asn Arg Arg Val Ala Glu 
            180                 185                 190         


Asp Leu Asn Leu Gly Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys 
        195                 200                 205             


Val Gly Asn Phe Thr Gly Leu Tyr Ser Ser Thr Val Pro Val Phe Asn 
    210                 215                 220                 


Pro Glu Trp Gln Thr Pro Ser Phe Pro Asn Ile His Leu Gln Glu Asp 
225                 230                 235                 240 


Ile Ile Asn Arg Cys Glu Gln Phe Val Gly Pro Leu Thr Val Asn Glu 
                245                 250                 255     


Lys Arg Arg Leu Lys Leu Ile Met Pro Ala Arg Phe Tyr Pro Asn Val 
            260                 265                 270         


Thr Lys Tyr Leu Pro Leu Asp Lys Gly Ile Lys Pro Tyr Tyr Pro Glu 
        275                 280                 285             


His Leu Val Asn His Tyr Phe Gln Thr Arg His Tyr Leu His Thr Leu 
    290                 295                 300                 


Trp Lys Ala Gly Ile Leu Tyr Lys Arg Glu Thr Thr Arg Ser Ala Ser 
305                 310                 315                 320 


Phe Cys Gly Ser Pro Tyr Ser Trp Glu Gln Glu Leu Gln His Gly Arg 
                325                 330                 335     


Leu Val Phe Gln Thr Ser Thr Arg His Gly Asp Glu Ser Phe Cys Gln 
            340                 345                 350         


Gln Ser Ser Gly Ile Leu Ser Arg Ser Pro Val Gly Pro Cys Leu Gln 
        355                 360                 365             


Ser Gln Leu Arg Lys Ser Arg Leu Gly Leu Gln Pro Gln Gln Gly His 
    370                 375                 380                 


Leu Ala Arg Arg Gln Gln Gly Arg Ser Gly Ser Ile Arg Ala Arg Val 
385                 390                 395                 400 


His Pro Thr Thr Arg Arg Pro Phe Gly Val Glu Pro Ser Gly Ser Gly 
                405                 410                 415     


His Thr Thr Asn Thr Ala Ser Ser Ser Ser Ser Cys Leu His Gln Ser 
            420                 425                 430         


Ala Val Arg Lys Ala Ala Tyr Ser His Leu Ser Thr Ser Lys Arg His 
        435                 440                 445             


Ser Ser Ser Gly His Ala Val Glu Leu His Asn Ile Pro Pro Asn Ser 
    450                 455                 460                 


Ala Arg Ser Gln Ser Glu Gly Pro Val Phe Ser Cys Trp Trp Leu Gln 
465                 470                 475                 480 


Phe Arg Asn Ser Lys Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val 
                485                 490                 495     


Asn Leu Leu Glu Asp Trp Gly Pro Cys Thr Glu His Gly Glu His His 
            500                 505                 510         


Ile Arg Ile Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu 
        515                 520                 525             


Val Asp Lys Asn Pro His Asn Thr Thr Glu Ser Arg Leu Val Val Asp 
    530                 535                 540                 


Phe Ser Gln Phe Ser Arg Gly Asn Thr Arg Val Ser Trp Pro Lys Phe 
545                 550                 555                 560 


Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu 
                565                 570                 575     


Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu 
            580                 585                 590         


His Pro Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser 
        595                 600                 605             


Arg Tyr Val Ala Arg Leu Ser Ser Asn Ser Arg Ile Ile Asn His Gln 
    610                 615                 620                 


His Gly Thr Met Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr 
625                 630                 635                 640 


Val Ser Leu Leu Leu Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu 
                645                 650                 655     


Tyr Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val 
            660                 665                 670         


Gly Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser 
        675                 680                 685             


Val Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asn 
    690                 695                 700                 


Asn Val Val Leu Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe 
705                 710                 715                 720 


Thr Ala Val Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro 
                725                 730                 735     


Asn Lys Thr Lys Arg Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val 
            740                 745                 750         


Ile Gly Ser Trp Gly Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile 
        755                 760                 765             


Lys Glu Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys 
    770                 775                 780                 


Val Cys Gln Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr 
785                 790                 795                 800 


Gln Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser 
                805                 810                 815     


Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys 
            820                 825                 830         


Gln Tyr Leu Asn Leu Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys 
        835                 840                 845             


Gln Val Phe Ala Asn Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile Gly 
    850                 855                 860                 


His Gln Arg Met Arg Gly Thr Phe Val Ala Pro Leu Pro Ile His Thr 
865                 870                 875                 880 


Ala Gln Leu Leu Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala Lys 
                885                 890                 895     


Leu Ile Gly Thr Asp Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser 
            900                 905                 910         


Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr 
        915                 920                 925             


Ser Phe Val Tyr Val Pro Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser 
    930                 935                 940                 


Arg Gly Arg Leu Gly Leu Tyr Arg Pro Leu Leu Arg Leu Pro Phe Arg 
945                 950                 955                 960 


Pro Thr Thr Gly Arg Thr Ser Leu Tyr Ala Asp Ser Pro Ser Val Pro 
                965                 970                 975     


Ser His Leu Pro Asp Arg Val His Phe Ala Ser Pro Leu His Val Ala 
            980                 985                 990         


Trp Arg Pro Pro 
        995     


<210>  46
<211>  1023
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV core-pol fusion antigen sequence with Ig signal sequence

<400>  46

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Met Asp Ile Asp Pro 
            20                  25                  30          


Tyr Lys Glu Phe Gly Ala Ser Val Glu Leu Leu Ser Phe Leu Pro Ser 
        35                  40                  45              


Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu 
    50                  55                  60                  


Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr 
65                  70                  75                  80  


Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Asn Leu Ala 
                85                  90                  95      


Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala Ser Arg Glu Leu Val 
            100                 105                 110         


Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys Ile Arg Gln Leu Leu 
        115                 120                 125             


Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu 
    130                 135                 140                 


Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 
145                 150                 155                 160 


Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 
                165                 170                 175     


Ala Gly Ala Gly Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu 
            180                 185                 190         


Leu Leu Asp Asp Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu 
        195                 200                 205             


Ala Asp Glu Gly Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly 
    210                 215                 220                 


Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr 
225                 230                 235                 240 


Gly Leu Tyr Ser Ser Thr Val Pro Val Phe Asn Pro Glu Trp Gln Thr 
                245                 250                 255     


Pro Ser Phe Pro Asn Ile His Leu Gln Glu Asp Ile Ile Asn Arg Cys 
            260                 265                 270         


Glu Gln Phe Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Lys 
        275                 280                 285             


Leu Ile Met Pro Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro 
    290                 295                 300                 


Leu Asp Lys Gly Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His 
305                 310                 315                 320 


Tyr Phe Gln Thr Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile 
                325                 330                 335     


Leu Tyr Lys Arg Glu Thr Thr Arg Ser Ala Ser Phe Cys Gly Ser Pro 
            340                 345                 350         


Tyr Ser Trp Glu Gln Glu Leu Gln His Gly Arg Leu Val Phe Gln Thr 
        355                 360                 365             


Ser Thr Arg His Gly Asp Glu Ser Phe Cys Gln Gln Ser Ser Gly Ile 
    370                 375                 380                 


Leu Ser Arg Ser Pro Val Gly Pro Cys Leu Gln Ser Gln Leu Arg Lys 
385                 390                 395                 400 


Ser Arg Leu Gly Leu Gln Pro Gln Gln Gly His Leu Ala Arg Arg Gln 
                405                 410                 415     


Gln Gly Arg Ser Gly Ser Ile Arg Ala Arg Val His Pro Thr Thr Arg 
            420                 425                 430         


Arg Pro Phe Gly Val Glu Pro Ser Gly Ser Gly His Thr Thr Asn Thr 
        435                 440                 445             


Ala Ser Ser Ser Ser Ser Cys Leu His Gln Ser Ala Val Arg Lys Ala 
    450                 455                 460                 


Ala Tyr Ser His Leu Ser Thr Ser Lys Arg His Ser Ser Ser Gly His 
465                 470                 475                 480 


Ala Val Glu Leu His Asn Ile Pro Pro Asn Ser Ala Arg Ser Gln Ser 
                485                 490                 495     


Glu Gly Pro Val Phe Ser Cys Trp Trp Leu Gln Phe Arg Asn Ser Lys 
            500                 505                 510         


Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu Asp 
        515                 520                 525             


Trp Gly Pro Cys Thr Glu His Gly Glu His His Ile Arg Ile Pro Arg 
    530                 535                 540                 


Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn Pro 
545                 550                 555                 560 


His Asn Thr Thr Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser 
                565                 570                 575     


Arg Gly Asn Thr Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu 
            580                 585                 590         


Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu 
        595                 600                 605             


Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala Met 
    610                 615                 620                 


Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala Arg 
625                 630                 635                 640 


Leu Ser Ser Asn Ser Arg Ile Ile Asn His Gln His Gly Thr Met Gln 
                645                 650                 655     


Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu Leu 
            660                 665                 670         


Leu Tyr Lys Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro Ile 
        675                 680                 685             


Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe 
    690                 695                 700                 


Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala 
705                 710                 715                 720 


Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asn Asn Val Val Leu Gly 
                725                 730                 735     


Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala Val Thr Asn 
            740                 745                 750         


Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr Lys Arg 
        755                 760                 765             


Trp Gly Tyr Ser Leu Asn Phe Met Gly Tyr Val Ile Gly Ser Trp Gly 
    770                 775                 780                 


Thr Leu Pro Gln Glu His Ile Val Gln Lys Ile Lys Glu Cys Phe Arg 
785                 790                 795                 800 


Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile 
                805                 810                 815     


Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro 
            820                 825                 830         


Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala Phe Thr 
        835                 840                 845             


Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu Asn Leu 
    850                 855                 860                 


Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys Gln Val Phe Ala Asn 
865                 870                 875                 880 


Ala Thr Pro Thr Gly Trp Gly Leu Ala Ile Gly His Gln Arg Met Arg 
                885                 890                 895     


Gly Thr Phe Val Ala Pro Leu Pro Ile His Thr Ala Gln Leu Leu Ala 
            900                 905                 910         


Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala Lys Leu Ile Gly Thr Asp 
        915                 920                 925             


Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 
    930                 935                 940                 


Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 
945                 950                 955                 960 


Pro Ser Ala Leu Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly 
                965                 970                 975     


Leu Tyr Arg Pro Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly Arg 
            980                 985                 990         


Thr Ser Leu Tyr Ala Asp Ser Pro  Ser Val Pro Ser His  Leu Pro Asp 
        995                 1000                 1005             


Arg Val  His Phe Ala Ser Pro  Leu His Val Ala Trp  Arg Pro Pro 
    1010                 1015                 1020             


<210>  47
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCMV promoter sequence

<400>  47
accgccatgt tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt       60

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg      120

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac      180

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt      240

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa      300

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta      360

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg      420

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg      480

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc      540

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctcgttt      600

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagaca      660

ccgggaccga tccagcctcc gcgg                                             684


