
                                SEQUENCE LISTING

<110> PFIZER INC.
      CTXT PTY LTD

<120> Cycloalkyl and Heterocycloalkyl
  Benzisoxazole Sulfonamide Derivatives
  

<130> PC072524A

<150> US 62/863,802       
<151> 2019-06-19  

<150> US 62/953,473       
<151> 2019-12-24  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1
Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys
 1               5                  10                  15
Arg His Arg Lys
            20

<210> 2
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro
 1               5                  10                  15
Arg Lys Gln Leu
            20

<210> 3
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro
 1               5                  10                  15
Arg Lys Gln Leu Ala
            20

<210> 4
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified KAT5 protein

<400> 4
Met Gly His His His His His His Gly Thr Glu Asn Leu Tyr Phe Gln
 1               5                  10                  15
Gly Ser Ala Glu Val Gly Glu Ile Ile Glu Gly Cys Arg Leu Pro Val
            20                  25                  30
Leu Arg Arg Asn Gln Asp Asn Glu Asp Glu Trp Pro Leu Ala Glu Ile
        35                  40                  45
Leu Ser Val Lys Asp Ile Ser Gly Arg Lys Leu Phe Tyr Val His Tyr
    50                  55                  60
Ile Asp Phe Asn Lys Arg Leu Asp Glu Trp Val Thr His Glu Arg Leu
65                  70                  75                  80
Asp Leu Lys Lys Ile Gln Phe Pro Lys Lys Glu Ala Lys Thr Pro Thr
                85                  90                  95
Lys Asn Gly Leu Pro Gly Ser Arg Pro Gly Ser Pro Glu Arg Glu Val
            100                 105                 110
Lys Arg Lys Val Glu Val Val Ser Pro Ala Thr Pro Val Pro Ser Glu
        115                 120                 125
Thr Ala Pro Ala Ser Val Phe Pro Gln Asn Gly Ala Ala Arg Arg Ala
    130                 135                 140
Val Ala Ala Gln Pro Gly Arg Lys Arg Lys Ser Asn Cys Leu Gly Thr
145                 150                 155                 160
Asp Glu Asp Ser Gln Asp Ser Ser Asp Gly Ile Pro Ser Ala Pro Arg
                165                 170                 175
Met Thr Gly Ser Leu Val Ser Asp Arg Ser His Asp Asp Ile Val Thr
            180                 185                 190
Arg Met Lys Asn Ile Glu Cys Ile Glu Leu Gly Arg His Arg Leu Lys
        195                 200                 205
Pro Trp Tyr Phe Ser Pro Tyr Pro Gln Glu Leu Thr Thr Leu Pro Val
    210                 215                 220
Leu Tyr Leu Cys Glu Phe Cys Leu Lys Tyr Gly Arg Ser Leu Lys Cys
225                 230                 235                 240
Leu Gln Arg His Leu Thr Lys Cys Asp Leu Arg His Pro Pro Gly Asn
                245                 250                 255
Glu Ile Tyr Arg Lys Gly Thr Ile Ser Phe Phe Glu Ile Asp Gly Arg
            260                 265                 270
Lys Asn Lys Ser Tyr Ser Gln Asn Leu Cys Leu Leu Ala Lys Cys Phe
        275                 280                 285
Leu Asp His Lys Thr Leu Tyr Tyr Asp Thr Asp Pro Phe Leu Phe Tyr
    290                 295                 300
Val Met Thr Glu Tyr Asp Cys Lys Gly Phe His Ile Val Gly Tyr Phe
305                 310                 315                 320
Ser Lys Glu Lys Glu Ser Thr Glu Asp Tyr Asn Val Ala Cys Ile Leu
                325                 330                 335
Thr Leu Pro Pro Tyr Gln Arg Arg Gly Tyr Gly Lys Leu Leu Ile Glu
            340                 345                 350
Phe Ser Tyr Glu Leu Ser Lys Val Glu Gly Lys Thr Gly Thr Pro Glu
        355                 360                 365
Lys Pro Leu Ser Asp Leu Gly Leu Leu Ser Tyr Arg Ser Tyr Trp Ser
    370                 375                 380
Gln Thr Ile Leu Glu Ile Leu Met Gly Leu Lys Ser Glu Ser Gly Glu
385                 390                 395                 400
Arg Pro Gln Ile Thr Ile Asn Glu Ile Ser Glu Ile Thr Ser Ile Lys
                405                 410                 415
Lys Glu Asp Val Ile Ser Thr Leu Gln Tyr Leu Asn Leu Ile Asn Tyr
            420                 425                 430
Tyr Lys Gly Gln Tyr Ile Leu Thr Leu Ser Glu Asp Ile Val Asp Gly
        435                 440                 445
His Glu Arg Ala Met Leu Lys Arg Leu Leu Arg Ile Asp Ser Lys Cys
    450                 455                 460
Leu His Phe Thr Pro Lys Asp Trp Ser Lys Arg Gly Lys Trp Ala Ser
465                 470                 475                 480

<210> 5
<211> 791
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified KAT6A protein

<400> 5
Met Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys
 1               5                  10                  15
Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala
            20                  25                  30
Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln
        35                  40                  45
Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val
    50                  55                  60
Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala
65                  70                  75                  80
Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln
                85                  90                  95
Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln
            100                 105                 110
Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp
        115                 120                 125
Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys
    130                 135                 140
Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala
145                 150                 155                 160
Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly
                165                 170                 175
Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly
            180                 185                 190
Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu
        195                 200                 205
Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys
    210                 215                 220
Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr
225                 230                 235                 240
Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly
                245                 250                 255
Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp
            260                 265                 270
Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met
        275                 280                 285
Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr
    290                 295                 300
Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg
305                 310                 315                 320
Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu
                325                 330                 335
Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala
            340                 345                 350
His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp
        355                 360                 365
Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu
    370                 375                 380
Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu
385                 390                 395                 400
Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr
                405                 410                 415
Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp
            420                 425                 430
Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu
        435                 440                 445
Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile
    450                 455                 460
Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala
465                 470                 475                 480
Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala Thr
                485                 490                 495
Ser Gly Ser Gly His His His His His His Ser Ala Gly Glu Asn Leu
            500                 505                 510
Tyr Phe Gln Gly Ala Met Gly Arg Cys Pro Ser Val Ile Glu Phe Gly
        515                 520                 525
Lys Tyr Glu Ile His Thr Trp Tyr Ser Ser Pro Tyr Pro Gln Glu Tyr
    530                 535                 540
Ser Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu Lys Tyr Met
545                 550                 555                 560
Lys Ser Arg Thr Ile Leu Gln Gln His Met Lys Lys Cys Gly Trp Phe
                565                 570                 575
His Pro Pro Val Asn Glu Ile Tyr Arg Lys Asn Asn Ile Ser Val Phe
            580                 585                 590
Glu Val Asp Gly Asn Val Ser Thr Ile Tyr Cys Gln Asn Leu Cys Leu
        595                 600                 605
Leu Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr Asp Val Glu
    610                 615                 620
Pro Phe Leu Phe Tyr Val Leu Thr Gln Asn Asp Val Lys Gly Cys His
625                 630                 635                 640
Leu Val Gly Tyr Phe Ser Lys Glu Lys His Cys Gln Gln Lys Tyr Asn
                645                 650                 655
Val Ser Cys Ile Met Ile Leu Pro Gln Tyr Gln Arg Lys Gly Tyr Gly
            660                 665                 670
Arg Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Lys Arg Glu Gly Gln
        675                 680                 685
Ala Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg Leu Ser Tyr
    690                 695                 700
Met Ala Tyr Trp Lys Ser Val Ile Leu Glu Cys Leu Tyr His Gln Asn
705                 710                 715                 720
Asp Lys Gln Ile Ser Ile Lys Lys Leu Ser Lys Leu Thr Gly Ile Cys
                725                 730                 735
Pro Gln Asp Ile Thr Ser Thr Leu His His Leu Arg Met Leu Asp Phe
            740                 745                 750
Arg Ser Asp Gln Phe Val Ile Ile Arg Arg Glu Lys Leu Ile Gln Asp
        755                 760                 765
His Met Ala Lys Leu Gln Leu Asn Leu Arg Pro Val Asp Val Asp Pro
    770                 775                 780
Glu Cys Leu Arg Trp Thr Pro
785                 790

<210> 6
<211> 307
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified KAT7 protein

<400> 6
Met Gly His His His His His His Gly Thr Glu Asn Leu Tyr Phe Gln
 1               5                  10                  15
Gly Ser Arg Leu Gln Gly Gln Ile Thr Glu Gly Ser Asn Met Ile Lys
            20                  25                  30
Thr Ile Ala Phe Gly Arg Tyr Glu Leu Asp Thr Trp Tyr His Ser Pro
        35                  40                  45
Tyr Pro Glu Glu Tyr Ala Arg Leu Gly Arg Leu Tyr Met Cys Glu Phe
    50                  55                  60
Cys Leu Lys Tyr Met Lys Ser Gln Thr Ile Leu Arg Arg His Met Ala
65                  70                  75                  80
Lys Cys Val Trp Lys His Pro Pro Gly Asp Glu Ile Tyr Arg Lys Gly
                85                  90                  95
Ser Ile Ser Val Phe Glu Val Asp Gly Lys Lys Asn Lys Ile Tyr Cys
            100                 105                 110
Gln Asn Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp His Lys Thr Leu
        115                 120                 125
Tyr Tyr Asp Val Glu Pro Phe Leu Phe Tyr Val Met Thr Glu Ala Asp
    130                 135                 140
Asn Thr Gly Cys His Leu Ile Gly Tyr Phe Ser Lys Glu Lys Asn Ser
145                 150                 155                 160
Phe Leu Asn Tyr Asn Val Ser Cys Ile Leu Thr Met Pro Gln Tyr Met
                165                 170                 175
Arg Gln Gly Tyr Gly Lys Met Leu Ile Asp Phe Ser Tyr Leu Leu Ser
            180                 185                 190
Lys Val Glu Glu Lys Val Gly Ser Pro Glu Arg Pro Leu Ser Asp Leu
        195                 200                 205
Gly Leu Ile Ser Tyr Arg Ser Tyr Trp Lys Glu Val Leu Leu Arg Tyr
    210                 215                 220
Leu His Asn Phe Gln Gly Lys Glu Ile Ser Ile Lys Glu Ile Ser Gln
225                 230                 235                 240
Glu Thr Ala Val Asn Pro Val Asp Ile Val Ser Thr Leu Gln Ala Leu
                245                 250                 255
Gln Met Leu Lys Tyr Trp Lys Gly Lys His Leu Val Leu Lys Arg Gln
            260                 265                 270
Asp Leu Ile Asp Glu Trp Ile Ala Lys Glu Ala Lys Arg Ser Asn Ser
        275                 280                 285
Asn Lys Thr Met Asp Pro Ser Cys Leu Lys Trp Thr Pro Pro Lys Gly
    290                 295                 300
Thr Ala Ser
305
