                               SEQUENCE LISTING

<110> VARIATION BIOTECHNOLOGIES INC.
      BRII BIOSCIENCES LIMITED
 
<120> IMPROVED FORMULATIONS OF INTERFERON-ALPHA FOR TREATMENT OF 
      HEPATITIS B

<130> PAT 108967W-90

<140> PCT/IB2020/000539
<141> 2020-06-19

<150> 62/864,930
<151> 2019-06-21

<160> 3     

<170> PatentIn version 3.5

<210> 1
<211> 399
<212> PRT
<213> Hepatitis B virus

<400> 1
Met Gly Leu Ser Trp Thr Val Pro Leu Glu Trp Gly Lys Asn Gln Ser 
1               5                   10                  15      


Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Leu Asn Ser Asn Lys 
        35                  40                  45              


Asp His Trp Pro Gln Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Ser Gln Ala 
65                  70                  75                  80  


Gln Gly Thr Leu His Thr Val Pro Ala Val Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Thr Lys Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
            100                 105                 110         


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
        115                 120                 125             


Ala Leu Gln His Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
    130                 135                 140                 


Ser Ser Ser Gly Thr Val Asn Pro Ala Gln Asn Ile Ala Ser His Ile 
145                 150                 155                 160 


Ser Ser Ile Ser Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu Asn 
                165                 170                 175     


Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe 
            180                 185                 190         


Phe Leu Leu Thr Arg Ile Leu Thr Leu Leu Cys Leu Ile Phe Leu Leu 
        195                 200                 205             


Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Cys Leu Gly Gln 
    210                 215                 220                 


Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro 
225                 230                 235                 240 


Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe 
                245                 250                 255     


Leu Phe Ile Leu Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 
            260                 265                 270         


Leu Asp Tyr Gln Gly Met Leu Pro Pro Leu Ile Pro Gly Ser Thr Thr 
        275                 280                 285             


Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn 
    290                 295                 300                 


Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys 
305                 310                 315                 320 


Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp 
                325                 330                 335     


Glu Trp Gly Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe 
            340                 345                 350         


Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 
        355                 360                 365             


Trp Met Met Trp Tyr Trp Gly Pro Asn Leu Tyr Asn Ile Leu Ser Pro 
    370                 375                 380                 


Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
385                 390                 395                 


<210> 2
<211> 226
<212> PRT
<213> Hepatitis B virus

<400> 2
Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Tyr Leu Trp Glu Trp Gly Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Asn Leu Tyr Asn Ile 
        195                 200                 205             


Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210> 3
<211> 281
<212> PRT
<213> Hepatitis B virus

<400> 3
Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln His Pro Arg 
1               5                   10                  15      


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
            20                  25                  30          


Asn Pro Ala Gln Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ser Arg 
        35                  40                  45              


Thr Gly Asp Pro Ala Pro Asn Met Glu Asn Ile Thr Ser Gly Phe Leu 
    50                  55                  60                  


Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 
65                  70                  75                  80  


Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 
                85                  90                  95      


Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr 
            100                 105                 110         


Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg 
        115                 120                 125             


Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 
    130                 135                 140                 


Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 
145                 150                 155                 160 


Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys 
                165                 170                 175     


Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys 
            180                 185                 190         


Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro 
        195                 200                 205             


Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Gly Ser Val Arg 
    210                 215                 220                 


Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly 
225                 230                 235                 240 


Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr Trp 
                245                 250                 255     


Gly Pro Asn Leu Tyr Asn Ile Leu Ser Pro Phe Ile Pro Leu Leu Pro 
            260                 265                 270         


Ile Phe Phe Cys Leu Trp Val Tyr Ile 
        275                 280     


