                         SEQUENCE LISTING

<110>  INSERM
 
<120>  ANTI- PROTEASE NEXIN-1 CONFORMATIONAL SINGLE DOMAIN ANTIBODIES 
       AND USES THEREOF

<130>  BIO19217 BOUTON

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 CDR1

<400>  1

Ser Thr Trp Phe Arg Glu Ile 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 CDR2

<400>  2

Ser Asp Pro Thr Trp His Ala 
1               5           


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 CDR3

<400>  3

Pro Leu Ala Gly Thr Glu Ser Ile His Trp Trp Asp Pro Trp His Glu 
1               5                   10                  15      


Ser Ser 
        


<210>  4
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11

<400>  4

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Trp Phe Arg Glu 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asp Pro Thr Trp His Ala Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Pro Leu Ala Gly Thr Glu Ser Ile His Trp Trp Asp Pro Trp 
            100                 105                 110         


His Glu Ser Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F06 CDR1

<400>  5

Asp Thr Trp Ser Leu Glu Ile 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F06 CDR2

<400>  6

Ser Glu Asp Gly Trp His Ala 
1               5           


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F06 CDR3

<400>  7

Lys Ile Glu Asn Trp Ile Gln Ala Val Glu Gly Glu Met Ser Asp 
1               5                   10                  15  


<210>  8
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F06

<400>  8

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Trp Ser Leu Glu 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Glu Asp Gly Trp His Ala Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Ile Glu Asn Trp Ile Gln Ala Val Glu Gly Glu Met Ser 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A08 CDR1

<400>  9

Tyr Tyr Ser Tyr Ser Ser Thr 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A08 CDR2

<400>  10

Phe Tyr Ser Asp Met Ala His 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A08 CDR3

<400>  11

Ala Phe Ser Lys Leu Gly Lys Ile Lys 
1               5                   


<210>  12
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A08

<400>  12

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Tyr Ser Tyr Ser Ser 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Phe Tyr Ser Asp Met Ala His Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Phe Ser Lys Leu Gly Lys Ile Lys Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  13

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  14

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
1               5                   10                  15      


Ala Ile Ser 
            


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  15

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys Ala 
        35                  


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  16

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  17
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11-bv

<400>  17

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Trp Phe Arg Glu 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asp Pro Thr Trp His Ala Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Pro Leu Ala Gly Thr Glu Ser Ile His Trp Trp Asp Pro Trp 
            100                 105                 110         


His Glu Ser Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Trp 
145                 150                 155                 160 


Phe Arg Glu Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Phe Val Ser Ala Ile Ser Ser Asp Pro Thr Trp His Ala Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Ala Pro Leu Ala Gly Thr Glu Ser Ile His Trp Trp 
225                 230                 235                 240 


Asp Pro Trp His Glu Ser Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  18
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11-F06

<400>  18

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Trp Phe Arg Glu 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asp Pro Thr Trp His Ala Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Pro Leu Ala Gly Thr Glu Ser Ile His Trp Trp Asp Pro Trp 
            100                 105                 110         


His Glu Ser Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Trp Ser Leu Glu 
                165                 170                 175     


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ser Ala Ile Ser Ser Glu Asp Gly Trp His Ala Tyr Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys Ile Glu Asn Trp Ile Gln Ala Val Glu Gly Glu Met Ser 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 


<210>  19
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11-A08

<400>  19

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Trp Phe Arg Glu 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asp Pro Thr Trp His Ala Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Pro Leu Ala Gly Thr Glu Ser Ile His Trp Trp Asp Pro Trp 
            100                 105                 110         


His Glu Ser Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Tyr Ser Tyr Ser Ser 
                165                 170                 175     


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ser Ala Ile Ser Phe Tyr Ser Asp Met Ala His Tyr Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ala Phe Ser Lys Leu Gly Lys Ile Lys Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser 
            260             


