               SEQUENCE LISTING

<110> Julius-Maximilians-Universität Würzburg

<120> Ultramodular IgG3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design

<130> 223730

<160> 174

<170> BiSSAP 1.3.6

<210> 1
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> 15 aa MiH repeat sequence

<400> 1
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  

<210> 2
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Upper Hinge

<400> 2
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      
Pro 
    

<210> 3
<211> 245
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH_Linker_VL

<400> 3
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 
Val Thr Val Ser Ser 
                245 

<210> 4
<211> 246
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD20_Leu16 VL_Linker_VH

<400> 4
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             
Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
    130                 135                 140                 
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp 
145                 150                 155                 160 
Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr 
                165                 170                 175     
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
            180                 185                 190         
Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
        195                 200                 205             
Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn 
    210                 215                 220                 
Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
225                 230                 235                 240 
Thr Val Thr Val Ser Ser 
                245     

<210> 5
<211> 240
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_2A2 VH_4GS3_VL

<400> 5
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met 
    130                 135                 140                 
Ser Thr Thr Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
145                 150                 155                 160 
Asn Val Asp Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
                165                 170                 175     
Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
            180                 185                 190         
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             
Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
    210                 215                 220                 
Asp Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 



<210> 6
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_4-2 VH_4GS3_VL

<400> 6
Gln Glu Gln Gln Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  
Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Asp His Pro Thr Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val 
    130                 135                 140                 
Ser Leu Gly Gln Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly 
145                 150                 155                 160 
Ser Lys Ala Val His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly 
                165                 170                 175     
Leu Leu Ile Tyr Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         
Phe Ser Gly Ser Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly 
        195                 200                 205             
Ala Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
    210                 215                 220                 
Ser Ala Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
225                 230                 235                 

<210> 7
<211> 241
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R11 VH_4GS3_VL

<400> 7
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly 
    130                 135                 140                 
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr 
                165                 170                 175     
Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly 
        195                 200                 205             
Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly 
    210                 215                 220                 
Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val 
225                 230                 235                 240 
Lys 
    

<210> 8
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12 VH_Linker_VL

<400> 8
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly 
                245             

<210> 9
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_4-1 VH_4GS3_VL

<400> 9
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val 
    130                 135                 140                 
Gly Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 
Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 
                165                 170                 175     
Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
            180                 185                 190         
Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln 
        195                 200                 205             
Arg Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala 
    210                 215                 220                 
Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 

<210> 10
<211> 238
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_ERCS409 VH_4GS3_VL

<400> 10
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Gly 
            20                  25                  30          
Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Arg Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Tyr Tyr Gly Asp Ser Gly Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Thr Ser Val 
    130                 135                 140                 
Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Gly Ser Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Lys Gly Gly Arg Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Gly 
        195                 200                 205             
Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Ser Pro 
    210                 215                 220                 
Asn Gly Trp Ala Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
225                 230                 235             

<210> 11
<211> 241
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_huLuc63 VH_4GS3_VL

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 
Gln Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     
Val Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
            180                 185                 190         
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 
Tyr Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 
Lys 
    

<210> 12
<211> 252
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_BV10 VH_4GS3_VL

<400> 12
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 
Ser Pro Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Ser 
145                 150                 155                 160 
Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
                165                 170                 175     
Met Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
            180                 185                 190         
Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
        195                 200                 205             
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
    210                 215                 220                 
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu 
225                 230                 235                 240 
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
                245                 250         

<210> 13
<211> 241
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_4G8 VH_4GS3_VL

<400> 13
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 
Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 
Ser Ile Ser Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser 
                165                 170                 175     
Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro 
            180                 185                 190         
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
        195                 200                 205             
Asn Ser Val Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser 
    210                 215                 220                 
Asn Thr Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 
Arg 
    

<210> 14
<211> 238
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv Siglec-6_JML-1 VH_4GS3_VL

<400> 14
Lys Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Gln Thr Ile Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
    210                 215                 220                 
Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
225                 230                 235             

<210> 15
<211> 240
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v7 VH_4GS3_VL

<400> 15
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Arg Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile His His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ala Ile Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln 
    130                 135                 140                 
Ser Val Thr Pro Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 
Asp Ile Gly Asn Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
                165                 170                 175     
Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro 
            180                 185                 190         
Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 
Asn Ser Trp Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 



<210> 16
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v11 VH_4GS3_VL

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Phe 
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Leu 
        35                  40                  45              
Gly Gly Ile Val Ala Ser Leu Gly Ser Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Asp Lys Leu Thr Ile Thr Val Asp Glu Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  
Met Glu Met Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser 
    130                 135                 140                 
Val Thr Pro Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
145                 150                 155                 160 
Ile Gly Thr Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     
Lys Leu Leu Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser 
            180                 185                 190         
Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Tyr 
        195                 200                 205             
Ser Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
    210                 215                 220                 
Ser Trp Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 

<210> 17
<211> 246
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA30 VH_4GS3_VL

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 
Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala 
        195                 200                 205             
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210> 18
<211> 246
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA50 VH_4GS3_VL

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 
Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 
    210                 215                 220                 
Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210> 19
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats heavy chain variable region

<400> 19
Gln Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Phe Thr Asn Tyr 
            20                  25                  30          
Asp Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ala Val Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Glu Asp Tyr Arg Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats heavy CDR1

<400> 20
Gly Phe Ser Phe Thr Asn Tyr 
1               5           

<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats heavy CDR2

<400> 21
Trp Ala Val Gly Ser 
1               5   

<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats heavy CDR3

<400> 22
Glu Glu Asp Tyr Arg Tyr Gly Met Asp Tyr 
1               5                   10  

<210> 23
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats light chain variable region

<400> 23
Glu Leu Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 24
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats light CDR1

<400> 24
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      



<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats light CDR2

<400> 25
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> anti MiH repeats light CDR3

<400> 26
Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   

<210> 27
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH

<400> 27
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         

<210> 28
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VL

<400> 28
Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          
Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 

<210> 29
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD20_Leu16 VL

<400> 29
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 30
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD20_Leu16 VH

<400> 30
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 31
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_2A2 VH

<400> 31
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             

<210> 32
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_2A2 VL

<400> 32
Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ala Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 33
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_4-2 VH

<400> 33
Gln Glu Gln Gln Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  
Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Asp His Pro Thr Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 34
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_4-2 VL

<400> 34
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105         

<210> 35
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R11 VH

<400> 35
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Ile Ser Ser 
        115     

<210> 36
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R11 VL

<400> 36
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile 
        35                  40                  45              
Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser 
                85                  90                  95      
Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 

<210> 37
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12 VH

<400> 37
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120     

<210> 38
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12 VL

<400> 38
Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser 
1               5                   10                  15      
Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr 
            20                  25                  30          
Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              
Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  
Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr 
                85                  90                  95      
Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         



<210> 39
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_4-1 VH

<400> 39
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 40
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_4-1 VL

<400> 40
Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly 
1               5                   10                  15      
Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg 
65                  70                  75                  80  
Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser 
                85                  90                  95      
Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 

<210> 41
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_ERCS409 VH

<400> 41
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Gly 
            20                  25                  30          
Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Arg Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Tyr Tyr Gly Asp Ser Gly Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_ERCS409 VL

<400> 42
Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Thr Ser Val Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  
Gly Arg Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Gly Val Gln Arg 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Ser Pro Asn Gly Trp 
                85                  90                  95      
Ala Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105         

<210> 43
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_huLuc63 VH

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 44
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_huLuc63 VL

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 45
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_BV10 VH

<400> 45
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             

<210> 46
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_BV10 VL

<400> 46
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Met Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Arg 
        

<210> 47
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_4G8 VH

<400> 47
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser 
        115             

<210> 48
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_4G8 VL

<400> 48
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  
Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Thr Trp Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210> 49
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv Siglec-6_JML-1 VH

<400> 49
Lys Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Gln Thr Ile Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 50
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv Siglec-6_JML-1 VL

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         

<210> 51
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v7 VH

<400> 51
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Arg Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile His His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ala Ile Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 52
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v7 VL

<400> 52
Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 53
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v11 VH

<400> 53
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Phe 
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Leu 
        35                  40                  45              
Gly Gly Ile Val Ala Ser Leu Gly Ser Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Asp Lys Leu Thr Ile Thr Val Asp Glu Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  
Met Glu Met Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 54
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v11 VL

<400> 54
Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Tyr Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 55
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA30 VH

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser 
        115                 

<210> 56
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA30 VL

<400> 56
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr 
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 57
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA50 VH

<400> 57
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser 
        115                 

<210> 58
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA50 VL

<400> 58
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 59
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CPRCP

<400> 59
Cys Pro Arg Cys Pro 
1               5   

<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> IgG3 lower hinge

<400> 60
Ala Pro Glu Leu Leu Gly Gly Pro 
1               5               

<210> 61
<211> 2149
<212> DNA
<213> Artificial Sequence


<220> 
<223> Lentiviral vector backbone 5’

<400> 61
gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      60

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg     120

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg     180

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt     240

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg     300

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga     360

attagatcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat ataaattaaa     420

acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg gcctgttaga     480

aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc agacaggatc     540

agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc atcaaaggat     600

agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa acaaaagtaa     660

gaaaaaagca cagcaagcag cagctgacac aggacacagc aatcaggtca gccaaaatta     720

ccctatagtg cagaacatcc aggggcaaat ggtacatcag gccatatcac ctagaacttt     780

aaatgcatgg gtaaaagtag tagaagagaa ggctttcagc ccagaagtga tacccatgtt     840

ttcagcatta tcagaaggag ccaccccaca agatttaaac accatgctaa acacagtggg     900

gggacatcaa gcagccatgc aaatgttaaa agagaccatc aatgaggaag ctgcaggcaa     960

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt    1020

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca    1080

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc    1140

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg    1200

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac    1260

tcatttgcac cactgctgtg ccttggatct acaaatggca gtattcatcc acaattttaa    1320

aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac    1380

agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttcgggttta    1440

ttacagggac agcagagatc cagtttgggg atcaattgca tgaagaatct gcttagggtt    1500

aggcgttttg cgctgcttcg cgaggatctg cgatcgctcc ggtgcccgtc agtgggcaga    1560

gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc    1620

ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt    1680

tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg    1740

caacgggttt gccgccagaa cacagctgaa gcttcgaggg gctcgcatct ctccttcacg    1800

cgcccgccgc cctacctgag gccgccatcc acgccggttg agtcgcgttc tgccgcctcc    1860

cgcctgtggt gcctcctgaa ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag    1920

accgggcctt tgtccggcgc tcccttggag cctacctaga ctcagccggc tctccacgct    1980

ttgcctgacc ctgcttgctc aactctacgt ctttgtttcg ttttctgttc tgcgccgtta    2040

cagatccaag ctgtgaccgg cgcctacggc tagcgccgcc accatgctgc tgctcgtgac    2100

atctctgctg ctgtgcgagc tgccccaccc cgcctttctg ctgatcccc                2149


<210> 62
<211> 5916
<212> DNA
<213> Artificial Sequence


<220> 
<223> Lentiviral vector backbone 3’

<400> 62
ctcgagggcg gaggcgaagg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac       60

ccaggcccca gaatgctgct gctcgtgacc agcctgctgc tgtgtgaact gcctcatcct      120

gcttttctgc tgattcctcg gaaagtgtgc aacggcatcg gcatcggaga gttcaaggac      180

tccctgagca tcaacgccac caacatcaag cacttcaaga actgcaccag catcagcggc      240

gacctgcaca tcctgcctgt ggcctttaga ggcgacagct tcacccacac accccccctg      300

gatccacagg aactggatat tctgaaaacc gtaaaggaaa tcacagggtt tttgctgatt      360

caggcttggc ctgaaaacag gacggacctc catgcctttg agaacctaga aatcatacgc      420

ggcaggacca agcaacatgg tcagttttct cttgcagtcg tcagcctgaa cataacatcc      480

ttgggattac gctccctcaa ggagataagt gatggagatg tgataatttc aggaaacaaa      540

aatttgtgct atgcaaatac aataaactgg aaaaaactgt ttgggacctc cggtcagaaa      600

accaaaatta taagcaacag aggtgaaaac agctgcaagg ccacaggcca ggtctgccat      660

gccttgtgct cccccgaggg ctgctggggc ccggagccca gggactgcgt ctcttgccgg      720

aatgtcagcc gaggcaggga atgcgtggac aagtgcaacc ttctggaggg tgagccaagg      780

gagtttgtgg agaactctga gtgcatacag tgccacccag agtgcctgcc tcaggccatg      840

aacatcacct gcacaggacg gggaccagac aactgtatcc agtgtgccca ctacattgac      900

ggcccccact gcgtcaagac ctgcccggca ggagtcatgg gagaaaacaa caccctggtc      960

tggaagtacg cagacgccgg ccatgtgtgc cacctgtgcc atccaaactg cacctacgga     1020

tgcactgggc caggtcttga aggctgtcca acgaatgggc ctaagatccc gtccatcgcc     1080

actgggatgg tgggggccct cctcttgctg ctggtggtgg ccctggggat cggcctcttc     1140

atgtgagcgg ccgctctaga cccgggctgc aggaattcga tatcaagctt atcgataatc     1200

aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt     1260

ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg     1320

ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc     1380

ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt     1440

ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg     1500

ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg     1560

gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct     1620

gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc     1680

cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc     1740

ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcatcga taccgtcgac     1800

tagccgtacc tttaagacca atgacttaca aggcagctgt agatcttagc cactttttaa     1860

aagaaaaggg gggactggaa gggctaattc actcccaaag aagacaagat ctgctttttg     1920

cctgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag     1980

ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc     2040

gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa     2100

tctctagcag aattcgatat caagcttatc gataccgtcg acctcgaggg ggggcccggt     2160

acccaattcg ccctatagtg agtcgtatta caattcactg gccgtcgttt tacaacgtcg     2220

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     2280

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     2340

gaatggcgaa tggaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt     2400

taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa     2460

gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag     2520

aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt     2580

gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac     2640

cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag     2700

gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg     2760

cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc aggtggcact     2820

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     2880

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     2940

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     3000

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     3060

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     3120

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     3180

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     3240

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     3300

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     3360

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     3420

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3480

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3540

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3600

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3660

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3720

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3780

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3840

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3900

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     3960

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     4020

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     4080

gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta gccgtagtta     4140

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     4200

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     4260

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     4320

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     4380

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     4440

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4500

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4560

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4620

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4680

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     4740

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg     4800

cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag     4860

ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga     4920

attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta cgccaagctc     4980

gaaattaacc ctcactaaag ggaacaaaag ctggagctcc accgcggtgg cggcctcgag     5040

gtcgagatcc ggtcgaccag caaccatagt cccgccccta actccgccca tcccgcccct     5100

aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc     5160

agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg     5220

aggcctaggc ttttgcaaaa agcttcgacg gtatcgattg gctcatgtcc aacattaccg     5280

ccatgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt     5340

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga     5400

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca     5460

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca     5520

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg     5580

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc     5640

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt     5700

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt     5760

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg     5820

acgcaaatgg gcggtaggcg tgtacggaat tcggagtggc gagccctcag atcctgcata     5880

taagcagctg ctttttgcct gtactgggtc tctctg                               5916


<210> 63
<211> 1050
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sleeping Beauty vector backbone 5’

<400> 63
caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg      60

ccagtgagcg cgcgtaatac gactcactat agggcgaatt ggagctcggg tccctataca     120

gttgaagtcg gaagtttaca tacacttaag ttggagtcat taaaactcgt ttttcaacta     180

ctccacaaat ttcttgttaa caaacaatag ttttggcaag tcagttagga catctacttt     240

gtgcatgaca caagtcattt ttccaacaat tgtttacaga cagattattt cacttataat     300

tcactgtatc acaattccag tgggtcagaa gtttacatac actaagttga ctgtgccttt     360

aaacagcttg gaaaattcca gaaaatgatg tcatggcttt agaagcttga tatccatgga     420

attcggatct gcgatcgctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc     480

cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg     540

gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa     600

ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga     660

acacagctga agcttcgagg ggctcgcatc tctccttcac gcgcccgccg ccctacctga     720

ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga     780

actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg     840

ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac cctgcttgct     900

caactctacg tctttgtttc gttttctgtt ctgcgccgtt acagatccaa gctgtgaccg     960

gcgcctacgg ctagcgccgc caccatgctg ctgctcgtga catctctgct gctgtgcgag    1020

ctgccccacc ccgcctttct gctgatcccc                                     1050


<210> 64
<211> 4270
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sleeping Beauty vector backbone 3’

<400> 64
ctcgagggcg gaggcgaagg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac       60

ccaggcccca gaatgctgct gctcgtgacc agcctgctgc tgtgtgaact gcctcatcct      120

gcttttctgc tgattcctcg gaaagtgtgc aacggcatcg gcatcggaga gttcaaggac      180

tccctgagca tcaacgccac caacatcaag cacttcaaga actgcaccag catcagcggc      240

gacctgcaca tcctgcctgt ggcctttaga ggcgacagct tcacccacac accccccctg      300

gatccacagg aactggatat tctgaaaacc gtaaaggaaa tcacagggtt tttgctgatt      360

caggcttggc ctgaaaacag gacggacctc catgcctttg agaacctaga aatcatacgc      420

ggcaggacca agcaacatgg tcagttttct cttgcagtcg tcagcctgaa cataacatcc      480

ttgggattac gctccctcaa ggagataagt gatggagatg tgataatttc aggaaacaaa      540

aatttgtgct atgcaaatac aataaactgg aaaaaactgt ttgggacctc cggtcagaaa      600

accaaaatta taagcaacag aggtgaaaac agctgcaagg ccacaggcca ggtctgccat      660

gccttgtgct cccccgaggg ctgctggggc ccggagccaa gggactgcgt ctcttgccgg      720

aatgtcagcc gaggcaggga atgcgtggac aagtgcaacc ttctggaggg tgagccaagg      780

gagtttgtgg agaactctga gtgcatacag tgccacccag agtgcctgcc tcaggccatg      840

aacatcacct gcacaggacg gggaccagac aactgtatcc agtgtgccca ctacattgac      900

ggcccccact gcgtcaagac ctgcccggca ggagtcatgg gagaaaacaa caccctggtc      960

tggaagtacg cagacgccgg ccatgtgtgc cacctgtgcc atccaaactg cacctacgga     1020

tgcactgggc caggtcttga aggctgtcca acgaatgggc ctaagatccc gtccatcgcc     1080

actgggatgg tgggggccct cctcttgctg ctggtggtgg ccctagggat cggcctcttc     1140

atgtgagcgg ccgctctaga tggccagatc tagcttgtgg aaggctactc gaaatgtttg     1200

acccaagtta aacaatttaa aggcaatgct accaaatact aattgagtgt atgtaaactt     1260

ctgacccact gggaatgtga tgaaagaaat aaaagctgaa atgaatcatt ctctctacta     1320

ttattctgat atttcacatt cttaaaataa agtggtgatc ctaactgacc taagacaggg     1380

aatttttact aggattaaat gtcaggaatt gtgaaaaagt gagtttaaat gtatttggct     1440

aaggtgtatg taaacttccg acttcaactg tataggggtc ctctagctag agtcgacctc     1500

gagggggggc ccggtaccca gcttttgttc cctttagtga gggttaattg cgcgcttggc     1560

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa     1620

catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac     1680

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca     1740

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc     1800

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     1860

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     1920

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     1980

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     2040

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     2100

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct     2160

ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg     2220

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct     2280

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat     2340

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg     2400

ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa     2460

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt     2520

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     2580

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt     2640

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     2700

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat     2760

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac     2820

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg     2880

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag     2940

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt     3000

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt     3060

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt     3120

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt     3180

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct     3240

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt     3300

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac     3360

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa     3420

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa     3480

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca     3540

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct     3600

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga     3660

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc     3720

tgacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac     3780

cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc     3840

cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt     3900

tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg     3960

gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag     4020

tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt     4080

ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt     4140

taacgcgaat tttaacaaaa tattaacgct tacaatttcc attcgccatt caggctgcgc     4200

aactgttggg aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg     4260

ggatgtgctg                                                            4270


<210> 65
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR transmembrane domain

<400> 65
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              

<210> 66
<211> 42
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR 4-1BB domain

<400> 66
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210> 67
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAR CD3 zeta domain

<400> 67
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         



<210> 68
<211> 533
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD19 CAR

<400> 68
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Glu Leu Lys Thr Pro 
            100                 105                 110         
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
        115                 120                 125             
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
    130                 135                 140                 
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
145                 150                 155                 160 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
                165                 170                 175     
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
            180                 185                 190         
Pro Pro Cys Pro Arg Cys Pro Glu Val Lys Leu Gln Glu Ser Gly Pro 
        195                 200                 205             
Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
    210                 215                 220                 
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
225                 230                 235                 240 
Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
                245                 250                 255     
Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
            260                 265                 270         
Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        275                 280                 285             
Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    290                 295                 300                 
Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
305                 310                 315                 320 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                325                 330                 335     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
            340                 345                 350         
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
        355                 360                 365             
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
    370                 375                 380                 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
385                 390                 395                 400 
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                405                 410                 415     
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            420                 425                 430         
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        435                 440                 445             
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    450                 455                 460                 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
465                 470                 475                 480 
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                485                 490                 495     
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            500                 505                 510         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        515                 520                 525             
Ala Leu Pro Pro Arg 
    530             

<210> 69
<211> 6919
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD19 CAR SB vector

<400> 69
caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg       60

ccagtgagcg cgcgtaatac gactcactat agggcgaatt ggagctcggg tccctataca      120

gttgaagtcg gaagtttaca tacacttaag ttggagtcat taaaactcgt ttttcaacta      180

ctccacaaat ttcttgttaa caaacaatag ttttggcaag tcagttagga catctacttt      240

gtgcatgaca caagtcattt ttccaacaat tgtttacaga cagattattt cacttataat      300

tcactgtatc acaattccag tgggtcagaa gtttacatac actaagttga ctgtgccttt      360

aaacagcttg gaaaattcca gaaaatgatg tcatggcttt agaagcttga tatccatgga      420

attcggatct gcgatcgctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc      480

cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg      540

gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa      600

ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga      660

acacagctga agcttcgagg ggctcgcatc tctccttcac gcgcccgccg ccctacctga      720

ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga      780

actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg      840

ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac cctgcttgct      900

caactctacg tctttgtttc gttttctgtt ctgcgccgtt acagatccaa gctgtgaccg      960

gcgcctacgg ctagcgccgc caccatgctg ctgctcgtga catctctgct gctgtgcgag     1020

ctgccccacc ccgcctttct gctgatcccc gacatccaga tgacccagac caccagcagc     1080

ctgagcgcca gcctgggcga tagagtgacc atcagctgca gagccagcca ggacatcagc     1140

aagtacctga actggtatca gcagaaaccc gacggcaccg tgaagctgct gatctaccac     1200

accagcagac tgcacagcgg cgtgcccagc agattttctg gcagcggctc cggcaccgac     1260

tacagcctga ccatctccaa cctggaacag gaagatattg ctacctactt ctgtcagcaa     1320

ggcaacaccc tgccctacac cttcggcgga ggcaccaagc tggaaatcac cgaactgaaa     1380

accccgcttg gcgacaccac ccacacctgt cctagatgtc ccgaacccaa gagctgcgat     1440

acccccccac cttgccctag atgccccgag cctaagtcct gcgacacccc tcctccatgc     1500

cctcggtgtc ctgagcctaa gagctgtgac acaccacccc cctgccccag atgtccagag     1560

ccaaaatctt gtgatacccc tcccccctgt ccccgctgcc cagaacccaa gtcctgtgat     1620

actccacctc cttgtccacg gtgccccgaa gtgaaactgc aggaaagcgg ccctggactg     1680

gtggccccaa gccagtctct gagcgtgacc tgtaccgtgt ccggcgtgtc cctgcctgac     1740

tatggcgtgt cctggatcag acagcccccc agaaagggcc tggaatggct gggagtgatc     1800

tggggcagcg agacaaccta ctacaacagc gccctgaagt cccggctgac catcatcaag     1860

gacaactcca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc     1920

atctactact gcgccaagca ctactactac ggcggcagct acgctatgga ctactggggc     1980

cagggcacca gcgtgaccgt gtctagcgaa ctgaaaaccc ccctgggcga caccacccac     2040

acctgtccta gatgtccgga acccaagagc tgcgataccc ccccaccttg ccccagatgc     2100

cccatgtttt gggtgctggt ggtcgtgggc ggagtgctgg cctgttacag cctgctcgtg     2160

accgtggcct tcatcatctt ttgggtcaag cggggcagaa agaagctgct gtacatcttt     2220

aagcagccct tcatgcggcc cgtgcagacc acccaggaag aggacggctg ctcctgcaga     2280

ttccccgagg aagaagaagg cggctgcgag ctgagagtga agttcagcag atccgccgac     2340

gcccctgcct atcagcaggg ccagaaccag ctatacaacg agctgaacct gggcagacgg     2400

gaagagtacg acgtgctgga caagagaaga ggccgggacc ctgagatggg cggaaagccc     2460

agaagaaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     2520

gcctacagcg agatcggaat gaagggcgag cggcggagag gcaagggcca cgatggactg     2580

tatcagggcc tgagcaccgc caccaaggac acctatgacg ccctgcacat gcaggccctg     2640

ccccctagac tcgagggcgg aggcgaaggc agaggcagcc tgctgacatg tggcgacgtg     2700

gaagagaacc caggccccag aatgctgctg ctcgtgacca gcctgctgct gtgtgaactg     2760

cctcatcctg cttttctgct gattcctcgg aaagtgtgca acggcatcgg catcggagag     2820

ttcaaggact ccctgagcat caacgccacc aacatcaagc acttcaagaa ctgcaccagc     2880

atcagcggcg acctgcacat cctgcctgtg gcctttagag gcgacagctt cacccacaca     2940

ccccccctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     3000

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcctttga gaacctagaa     3060

atcatacgcg gcaggaccaa gcaacatggt cagttttctc ttgcagtcgt cagcctgaac     3120

ataacatcct tgggattacg ctccctcaag gagataagtg atggagatgt gataatttca     3180

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     3240

ggtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacaggccag     3300

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagccaag ggactgcgtc     3360

tcttgccgga atgtcagccg aggcagggaa tgcgtggaca agtgcaacct tctggagggt     3420

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga gtgcctgcct     3480

caggccatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     3540

tacattgacg gcccccactg cgtcaagacc tgcccggcag gagtcatggg agaaaacaac     3600

accctggtct ggaagtacgc agacgccggc catgtgtgcc acctgtgcca tccaaactgc     3660

acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc taagatcccg     3720

tccatcgcca ctgggatggt gggggccctc ctcttgctgc tggtggtggc cctagggatc     3780

ggcctcttca tgtgagcggc cgctctagat ggccagatct agcttgtgga aggctactcg     3840

aaatgtttga cccaagttaa acaatttaaa ggcaatgcta ccaaatacta attgagtgta     3900

tgtaaacttc tgacccactg ggaatgtgat gaaagaaata aaagctgaaa tgaatcattc     3960

tctctactat tattctgata tttcacattc ttaaaataaa gtggtgatcc taactgacct     4020

aagacaggga atttttacta ggattaaatg tcaggaattg tgaaaaagtg agtttaaatg     4080

tatttggcta aggtgtatgt aaacttccga cttcaactgt ataggggtcc tctagctaga     4140

gtcgacctcg agggggggcc cggtacccag cttttgttcc ctttagtgag ggttaattgc     4200

gcgcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat     4260

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag     4320

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg     4380

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc     4440

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     4500

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     4560

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     4620

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     4680

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     4740

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     4800

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     4860

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     4920

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     4980

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     5040

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac     5100

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     5160

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     5220

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     5280

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     5340

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga     5400

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt     5460

gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg     5520

agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga     5580

gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga     5640

agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg     5700

catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc     5760

aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc     5820

gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca     5880

taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac     5940

caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg     6000

ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc     6060

ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg     6120

tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac     6180

aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat     6240

actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata     6300

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa     6360

agtgccacct gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     6420

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     6480

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     6540

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     6600

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     6660

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     6720

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     6780

acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttcca ttcgccattc     6840

aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt acgccagctg     6900

gcgaaagggg gatgtgctg                                                  6919


<210> 70
<211> 9664
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD19 CAR LV vector

<400> 70
gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc       60

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      120

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      180

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      240

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      300

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      360

attagatcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat ataaattaaa      420

acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg gcctgttaga      480

aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc agacaggatc      540

agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc atcaaaggat      600

agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa acaaaagtaa      660

gaaaaaagca cagcaagcag cagctgacac aggacacagc aatcaggtca gccaaaatta      720

ccctatagtg cagaacatcc aggggcaaat ggtacatcag gccatatcac ctagaacttt      780

aaatgcatgg gtaaaagtag tagaagagaa ggctttcagc ccagaagtga tacccatgtt      840

ttcagcatta tcagaaggag ccaccccaca agatttaaac accatgctaa acacagtggg      900

gggacatcaa gcagccatgc aaatgttaaa agagaccatc aatgaggaag ctgcaggcaa      960

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     1020

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     1080

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     1140

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     1200

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     1260

tcatttgcac cactgctgtg ccttggatct acaaatggca gtattcatcc acaattttaa     1320

aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac     1380

agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttcgggttta     1440

ttacagggac agcagagatc cagtttgggg atcaattgca tgaagaatct gcttagggtt     1500

aggcgttttg cgctgcttcg cgaggatctg cgatcgctcc ggtgcccgtc agtgggcaga     1560

gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc     1620

ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt     1680

tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg     1740

caacgggttt gccgccagaa cacagctgaa gcttcgaggg gctcgcatct ctccttcacg     1800

cgcccgccgc cctacctgag gccgccatcc acgccggttg agtcgcgttc tgccgcctcc     1860

cgcctgtggt gcctcctgaa ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag     1920

accgggcctt tgtccggcgc tcccttggag cctacctaga ctcagccggc tctccacgct     1980

ttgcctgacc ctgcttgctc aactctacgt ctttgtttcg ttttctgttc tgcgccgtta     2040

cagatccaag ctgtgaccgg cgcctacggc tagcgccgcc accatgctgc tgctcgtgac     2100

atctctgctg ctgtgcgagc tgccccaccc cgcctttctg ctgatccccg acatccagat     2160

gacccagacc accagcagcc tgagcgccag cctgggcgat agagtgacca tcagctgcag     2220

agccagccag gacatcagca agtacctgaa ctggtatcag cagaaacccg acggcaccgt     2280

gaagctgctg atctaccaca ccagcagact gcacagcggc gtgcccagca gattttctgg     2340

cagcggctcc ggcaccgact acagcctgac catctccaac ctggaacagg aagatattgc     2400

tacctacttc tgtcagcaag gcaacaccct gccctacacc ttcggcggag gcaccaagct     2460

ggaaatcacc gaactgaaaa ccccgcttgg cgacaccacc cacacctgtc ctagatgtcc     2520

cgaacccaag agctgcgata cccccccacc ttgccctaga tgccccgagc ctaagtcctg     2580

cgacacccct cctccatgcc ctcggtgtcc tgagcctaag agctgtgaca caccaccccc     2640

ctgccccaga tgtccagagc caaaatcttg tgatacccct cccccctgtc cccgctgccc     2700

agaacccaag tcctgtgata ctccacctcc ttgtccacgg tgccccgaag tgaaactgca     2760

ggaaagcggc cctggactgg tggccccaag ccagtctctg agcgtgacct gtaccgtgtc     2820

cggcgtgtcc ctgcctgact atggcgtgtc ctggatcaga cagcccccca gaaagggcct     2880

ggaatggctg ggagtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc     2940

ccggctgacc atcatcaagg acaactccaa gagccaggtg ttcctgaaga tgaacagcct     3000

gcagaccgac gacaccgcca tctactactg cgccaagcac tactactacg gcggcagcta     3060

cgctatggac tactggggcc agggcaccag cgtgaccgtg tctagcgaac tgaaaacccc     3120

cctgggcgac accacccaca cctgtcctag atgtccggaa cccaagagct gcgacacccc     3180

tccaccttgc ccaagatgcc ccatgttctg ggtgctggtg gtcgtgggcg gagtgctggc     3240

ctgttatagc ctgctcgtga ccgtggcctt catcatcttt tgggtcaagc ggggcagaaa     3300

gaaactgctg tacatcttta agcagccctt catgcggccc gtgcagacca cccaggaaga     3360

ggacggctgc tcctgcagat tccccgagga agaagaaggc ggctgcgagc tgagagtgaa     3420

gttcagcaga tccgccgacg cccctgccta tcagcagggc cagaaccagc tgtacaacga     3480

gctgaacctg ggcagacggg aagagtacga cgtgctggac aagagaagag gccgggaccc     3540

tgagatgggc ggaaagccca gaagaaagaa cccccaggaa ggcctgtata acgaactgca     3600

gaaagacaag atggccgagg cctacagcga gatcggaatg aagggcgagc ggcggagagg     3660

caagggccac gatggactgt atcagggcct gagcaccgcc accaaggaca cctatgacgc     3720

cctgcacatg caggccctgc cccctagact cgagggcgga ggcgaaggca gaggcagcct     3780

gctgacatgt ggcgacgtgg aagagaaccc aggccccaga atgctgctgc tcgtgaccag     3840

cctgctgctg tgtgaactgc ctcatcctgc ttttctgctg attcctcgga aagtgtgcaa     3900

cggcatcggc atcggagagt tcaaggactc cctgagcatc aacgccacca acatcaagca     3960

cttcaagaac tgcaccagca tcagcggcga cctgcacatc ctgcctgtgg cctttagagg     4020

cgacagcttc acccacacac cccccctgga tccacaggaa ctggatattc tgaaaaccgt     4080

aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga cggacctcca     4140

tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc agttttctct     4200

tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg agataagtga     4260

tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa taaactggaa     4320

aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag gtgaaaacag     4380

ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct gctggggccc     4440

ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat gcgtggacaa     4500

gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt gcatacagtg     4560

ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg gaccagacaa     4620

ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct gcccggcagg     4680

agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc atgtgtgcca     4740

cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag gctgtccaac     4800

gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc tcttgctgct     4860

ggtggtggcc ctggggatcg gcctcttcat gtgagcggcc gctctagacc cgggctgcag     4920

gaattcgata tcaagcttat cgataatcaa cctctggatt acaaaatttg tgaaagattg     4980

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     5040

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     5100

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     5160

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     5220

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     5280

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa     5340

tcatcgtcct ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     5400

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     5460

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     5520

gccgcctccc cgcatcgata ccgtcgacta gccgtacctt taagaccaat gacttacaag     5580

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     5640

tcccaaagaa gacaagatct gctttttgcc tgtactgggt ctctctggtt agaccagatc     5700

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     5760

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc     5820

ctcagaccct tttagtcagt gtggaaaatc tctagcagaa ttcgatatca agcttatcga     5880

taccgtcgac ctcgaggggg ggcccggtac ccaattcgcc ctatagtgag tcgtattaca     5940

attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta     6000

atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg     6060

atcgcccttc ccaacagttg cgcagcctga atggcgaatg gaaattgtaa gcgttaatat     6120

tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc aataggccga     6180

aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga gtgttgttcc     6240

agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac     6300

cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt ttttggggtc     6360

gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta gagcttgacg     6420

gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag cgggcgctag     6480

ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg cgcttaatgc     6540

gccgctacag ggcgcgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg     6600

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat     6660

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat     6720

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt     6780

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag     6840

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa     6900

agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg     6960

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct     7020

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac     7080

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca     7140

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat     7200

accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact     7260

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc     7320

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga     7380

taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg     7440

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg     7500

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca     7560

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta     7620

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca     7680

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg     7740

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga     7800

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa     7860

tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc     7920

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg     7980

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac     8040

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct     8100

acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc     8160

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg     8220

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg     8280

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct     8340

ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga     8400

taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg     8460

cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc     8520

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag     8580

tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt     8640

tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa     8700

cagctatgac catgattacg ccaagctcga aattaaccct cactaaaggg aacaaaagct     8760

ggagctccac cgcggtggcg gcctcgaggt cgagatccgg tcgaccagca accatagtcc     8820

cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc     8880

atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat     8940

tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag cttcgacggt     9000

atcgattggc tcatgtccaa cattaccgcc atgttgacat tgattattga ctagttatta     9060

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata     9120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat     9180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga     9240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc     9300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt     9360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat     9420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag     9480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc     9540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggaattc     9600

ggagtggcga gccctcagat cctgcatata agcagctgct ttttgcctgt actgggtctc     9660

tctg                                                                  9664


<210> 71
<211> 319
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH_MiH5_VL

<400> 71
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Glu Leu Lys Thr Pro 
            100                 105                 110         
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
        115                 120                 125             
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
    130                 135                 140                 
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
145                 150                 155                 160 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
                165                 170                 175     
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
            180                 185                 190         
Pro Pro Cys Pro Arg Cys Pro Glu Val Lys Leu Gln Glu Ser Gly Pro 
        195                 200                 205             
Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
    210                 215                 220                 
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
225                 230                 235                 240 
Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
                245                 250                 255     
Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
            260                 265                 270         
Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        275                 280                 285             
Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    290                 295                 300                 
Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
305                 310                 315                 

<210> 72
<211> 320
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD20_Leu16 VL_MiH5_VH

<400> 72
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr Pro Leu 
            100                 105                 110         
Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
        115                 120                 125             
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
        195                 200                 205             
Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
    210                 215                 220                 
Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
225                 230                 235                 240 
Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
                245                 250                 255     
Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
            260                 265                 270         
Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
        275                 280                 285             
Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
    290                 295                 300                 
Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
305                 310                 315                 320 



<210> 73
<211> 317
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_2A2 VH_MiH5_VL

<400> 73
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
        115                 120                 125             
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    130                 135                 140                 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
145                 150                 155                 160 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
                165                 170                 175     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            180                 185                 190         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        195                 200                 205             
Cys Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr 
    210                 215                 220                 
Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp 
225                 230                 235                 240 
Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
                245                 250                 255     
Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
            260                 265                 270         
Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met 
        275                 280                 285             
Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr 
    290                 295                 300                 
Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315         

<210> 74
<211> 316
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_4-2 VH_MiH5_VL

<400> 74
Gln Glu Gln Gln Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  
Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Asp His Pro Thr Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
        115                 120                 125             
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
    130                 135                 140                 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
145                 150                 155                 160 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
                165                 170                 175     
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            180                 185                 190         
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        195                 200                 205             
Pro Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly 
    210                 215                 220                 
Gln Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala 
225                 230                 235                 240 
Val His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile 
                245                 250                 255     
Tyr Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
            260                 265                 270         
Ser Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala 
        275                 280                 285             
Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr 
    290                 295                 300                 
Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
305                 310                 315     

<210> 75
<211> 318
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R11 VH_MiH5_VL

<400> 75
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly Ala Val Gly 
    210                 215                 220                 
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
225                 230                 235                 240 
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile 
                245                 250                 255     
Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
            260                 265                 270         
Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg 
        275                 280                 285             
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser 
    290                 295                 300                 
Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 
305                 310                 315             

<210> 76
<211> 325
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12 VH_MiH5_VL

<400> 76
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly 
                325 

<210> 77
<211> 316
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_4-1 VH_MiH5_VL

<400> 77
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
        115                 120                 125             
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
    130                 135                 140                 
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
145                 150                 155                 160 
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
                165                 170                 175     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            180                 185                 190         
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Asp Pro 
        195                 200                 205             
Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly Asp Thr 
    210                 215                 220                 
Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp Leu Ser 
225                 230                 235                 240 
Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr Gln 
                245                 250                 255     
Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly 
            260                 265                 270         
Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp 
        275                 280                 285             
Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser Tyr Arg 
    290                 295                 300                 
Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315     

<210> 78
<211> 315
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_ERCS409 VH_MiH5_VL

<400> 78
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Gly 
            20                  25                  30          
Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Arg Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Tyr Tyr Gly Asp Ser Gly Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Thr Ser Val Ala Val Gly 
    210                 215                 220                 
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Trp 
225                 230                 235                 240 
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
            260                 265                 270         
Gly Arg Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Gly Val Gln Arg 
        275                 280                 285             
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Ser Pro Asn Gly Trp 
    290                 295                 300                 
Ala Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
305                 310                 315 

<210> 79
<211> 318
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_huLuc63 VH_MiH5_VL

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr 
        115                 120                 125             
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
    130                 135                 140                 
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
145                 150                 155                 160 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
                165                 170                 175     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            180                 185                 190         
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
        195                 200                 205             
Arg Cys Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    210                 215                 220                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
225                 230                 235                 240 
Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys 
                245                 250                 255     
Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
            260                 265                 270         
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        275                 280                 285             
Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser 
    290                 295                 300                 
Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
305                 310                 315             

<210> 80
<211> 329
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_BV10 VH_MiH5_VL

<400> 80
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Leu Lys Thr Pro 
        115                 120                 125             
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
    130                 135                 140                 
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
145                 150                 155                 160 
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
                165                 170                 175     
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            180                 185                 190         
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
        195                 200                 205             
Pro Pro Cys Pro Arg Cys Pro Asp Ile Val Met Thr Gln Ser Pro Ser 
    210                 215                 220                 
Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
225                 230                 235                 240 
Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Met Ala Trp 
                245                 250                 255     
Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala 
            260                 265                 270         
Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        275                 280                 285             
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    290                 295                 300                 
Ala Val Tyr Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu Thr Phe Gly 
305                 310                 315                 320 
Ala Gly Thr Lys Leu Glu Leu Lys Arg 
                325                 

<210> 81
<211> 318
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_4G8 VH_MiH5_VL

<400> 81
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
        115                 120                 125             
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    130                 135                 140                 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
145                 150                 155                 160 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
                165                 170                 175     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            180                 185                 190         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        195                 200                 205             
Cys Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr 
    210                 215                 220                 
Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 
225                 230                 235                 240 
Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 
                245                 250                 255     
Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 
            260                 265                 270         
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val 
        275                 280                 285             
Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Thr Trp 
    290                 295                 300                 
Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
305                 310                 315             

<210> 82
<211> 315
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv Siglec-6_JML-1 VH_MiH5_VL

<400> 82
Lys Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Gln Thr Ile Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    210                 215                 220                 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
225                 230                 235                 240 
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
            260                 265                 270         
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        275                 280                 285             
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
    290                 295                 300                 
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
305                 310                 315 

<210> 83
<211> 317
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v7 VH_MiH5_VL

<400> 83
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Arg Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile His His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ala Ile Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
        115                 120                 125             
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    130                 135                 140                 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
145                 150                 155                 160 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
                165                 170                 175     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            180                 185                 190         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        195                 200                 205             
Cys Pro Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser Val Thr 
    210                 215                 220                 
Pro Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly 
225                 230                 235                 240 
Asn Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
                245                 250                 255     
Leu Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser Arg Phe 
            260                 265                 270         
Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
        275                 280                 285             
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp 
    290                 295                 300                 
Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315         

<210> 84
<211> 316
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v11 VH_MiH5_VL

<400> 84
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Phe 
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Leu 
        35                  40                  45              
Gly Gly Ile Val Ala Ser Leu Gly Ser Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Asp Lys Leu Thr Ile Thr Val Asp Glu Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  
Met Glu Met Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
        115                 120                 125             
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
    130                 135                 140                 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
145                 150                 155                 160 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
                165                 170                 175     
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            180                 185                 190         
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        195                 200                 205             
Pro Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser Val Thr Pro 
    210                 215                 220                 
Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Thr 
225                 230                 235                 240 
Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                245                 250                 255     
Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser Arg Phe Arg 
            260                 265                 270         
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Tyr Ser Leu Glu 
        275                 280                 285             
Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro 
    290                 295                 300                 
His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315     

<210> 85
<211> 323
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA30 VH_MiH5_VL

<400> 85
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr 
        115                 120                 125             
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
    130                 135                 140                 
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
145                 150                 155                 160 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
                165                 170                 175     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            180                 185                 190         
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
        195                 200                 205             
Arg Cys Pro Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
    210                 215                 220                 
Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
225                 230                 235                 240 
Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
                245                 250                 255     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
            260                 265                 270         
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr 
        275                 280                 285             
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
    290                 295                 300                 
Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
305                 310                 315                 320 
Glu Ile Lys 
            

<210> 86
<211> 323
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA50 VH_MiH5_VL

<400> 86
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr 
        115                 120                 125             
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
    130                 135                 140                 
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
145                 150                 155                 160 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
                165                 170                 175     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            180                 185                 190         
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
        195                 200                 205             
Arg Cys Pro Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
    210                 215                 220                 
Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
225                 230                 235                 240 
Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
                245                 250                 255     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
            260                 265                 270         
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        275                 280                 285             
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
    290                 295                 300                 
Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
305                 310                 315                 320 
Glu Ile Lys 
            

<210> 87
<211> 247
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12 VH_Linker_VL

<400> 87
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Gly 
                245         

<210> 88
<211> 324
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12 VH_MiH5_VL

<400> 88
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Gly 
                

<210> 89
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12/V16 VH_Linker_VL

<400> 89
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly 
                245             

<210> 90
<211> 325
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12/V16 VH_MiH5_VL

<400> 90
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly 
                325 

<210> 91
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12/V20 VH_Linker_VL

<400> 91
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly 
                245             

<210> 92
<211> 325
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12/V20 VH_MiH5_VL

<400> 92
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly 
                325 

<210> 93
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12/V16-20 VH_Linker_VL

<400> 93
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly 
                245             

<210> 94
<211> 325
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ R12/V16-20 VH_MiH5_VL

<400> 94
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly 
                325 

<210> 95
<211> 247
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12/V16 VH_Linker_VL

<400> 95
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Gly 
                245         

<210> 96
<211> 323
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12/V16 VH_MiH5_VL

<400> 96
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
305                 310                 315                 320 
Thr Val Gly 
            

<210> 97
<211> 247
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12/V20 VH_Linker_VL

<400> 97
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Gly 
                245         

<210> 98
<211> 323
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12/V20 VH_MiH5_VL

<400> 98
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
305                 310                 315                 320 
Thr Val Gly 
            

<210> 99
<211> 247
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12/V16-20 VH_Linker_VL

<400> 99
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Gly 
                245         

<210> 100
<211> 323
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_ huR12/V16-20 VH_MiH5_VL

<400> 100
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
305                 310                 315                 320 
Thr Val Gly 
            

<210> 101
<211> 240
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_X3.12 VH_4GS3_VL

<400> 101
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala 
    130                 135                 140                 
Val Gly Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser 
145                 150                 155                 160 
Ser Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu 
                165                 170                 175     
Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         
Lys Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val 
        195                 200                 205             
Gln Arg Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp 
    210                 215                 220                 
Ala Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 



<210> 102
<211> 317
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_X3.12 VH_MiH5_VL

<400> 102
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
        115                 120                 125             
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
    130                 135                 140                 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
145                 150                 155                 160 
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
                165                 170                 175     
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            180                 185                 190         
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Asp 
        195                 200                 205             
Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly Asp 
    210                 215                 220                 
Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp Leu 
225                 230                 235                 240 
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
                245                 250                 255     
Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser 
            260                 265                 270         
Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu 
        275                 280                 285             
Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser Tyr 
    290                 295                 300                 
Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315         

<210> 103
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_XBR2-401-DM VH_4GS3_VL

<400> 103
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Gly Arg Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val 
    130                 135                 140                 
Gly Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 
Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 
                165                 170                 175     
Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
            180                 185                 190         
Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln 
        195                 200                 205             
Arg Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala 
    210                 215                 220                 
Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 

<210> 104
<211> 316
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_XBR2-401-DM VH_MiH5_VL

<400> 104
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Gly Arg Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
        115                 120                 125             
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
    130                 135                 140                 
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
145                 150                 155                 160 
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
                165                 170                 175     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            180                 185                 190         
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Asp Pro 
        195                 200                 205             
Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly Asp Thr 
    210                 215                 220                 
Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp Leu Ser 
225                 230                 235                 240 
Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr Gln 
                245                 250                 255     
Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly 
            260                 265                 270         
Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp 
        275                 280                 285             
Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser Tyr Arg 
    290                 295                 300                 
Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315     

<210> 105
<211> 241
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.5 VH_4GS3_VL

<400> 105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Ser Ser Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Lys Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser 
        195                 200                 205             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala 
    210                 215                 220                 
Asp Ala Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 
Lys 
    

<210> 106
<211> 318
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.5 VH_MiH5_VL

<400> 106
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    210                 215                 220                 
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp 
225                 230                 235                 240 
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
            260                 265                 270         
Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        275                 280                 285             
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser 
    290                 295                 300                 
Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315             

<210> 107
<211> 241
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.6 VH_4GS3_VL

<400> 107
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Ser Ser Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Lys Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser 
        195                 200                 205             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala 
    210                 215                 220                 
Asp Ala Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 
Lys 
    

<210> 108
<211> 318
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.6 VH_MiH5_VL

<400> 108
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    210                 215                 220                 
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp 
225                 230                 235                 240 
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
            260                 265                 270         
Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        275                 280                 285             
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser 
    290                 295                 300                 
Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
305                 310                 315             

<210> 109
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD28tm+CD28/zeta

<400> 109
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          
Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        35                  40                  45              
Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    50                  55                  60                  
Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
65                  70                  75                  80  
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                85                  90                  95      
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            100                 105                 110         
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        115                 120                 125             
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    130                 135                 140                 
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
145                 150                 155                 160 
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                165                 170                 175     
Ala Leu Pro Pro Arg 
            180     

<210> 110
<211> 182
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD28tm+4-1BB/zeta

<400> 110
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
            20                  25                  30          
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        35                  40                  45              
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    50                  55                  60                  
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
65                  70                  75                  80  
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                85                  90                  95      
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            100                 105                 110         
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        115                 120                 125             
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    130                 135                 140                 
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
145                 150                 155                 160 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                165                 170                 175     
Gln Ala Leu Pro Pro Arg 
            180         

<210> 111
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD28tm+CD28/4-1BB/zeta

<400> 111
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          
Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        35                  40                  45              
Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    50                  55                  60                  
Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        115                 120                 125             
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             

<210> 112
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD28tm+4-1BB/CD28/zeta

<400> 112
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
            20                  25                  30          
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        35                  40                  45              
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    50                  55                  60                  
Glu Gly Gly Cys Glu Leu Arg Ser Lys Arg Ser Arg Gly Gly His Ser 
65                  70                  75                  80  
Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                85                  90                  95      
Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            100                 105                 110         
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        115                 120                 125             
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             

<210> 113
<211> 140
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD28tm+zeta

<400> 113
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe 
            20                  25                  30          
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        35                  40                  45              
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    50                  55                  60                  
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
65                  70                  75                  80  
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                85                  90                  95      
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            100                 105                 110         
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        115                 120                 125             
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135                 140 

<210> 114
<211> 133
<212> PRT
<213> Artificial Sequence


<220> 
<223> ICOStm+zeta

<400> 114
Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      
Gly Cys Ile Leu Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            20                  25                  30          
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        35                  40                  45              
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    50                  55                  60                  
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
65                  70                  75                  80  
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                85                  90                  95      
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            100                 105                 110         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        115                 120                 125             
Ala Leu Pro Pro Arg 
    130             

<210> 115
<211> 175
<212> PRT
<213> Artificial Sequence


<220> 
<223> OX40tm+OX40/zeta

<400> 115
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      
Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu 
            20                  25                  30          
Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
        35                  40                  45              
Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg 
    50                  55                  60                  
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
65                  70                  75                  80  
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                85                  90                  95      
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            100                 105                 110         
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        115                 120                 125             
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    130                 135                 140                 
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
145                 150                 155                 160 
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                165                 170                 175 

<210> 116
<211> 518
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH_MiH5_VL_MiH0_ CD28tm+4-1BB/zeta

<400> 116
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Glu Leu Lys Thr Pro 
            100                 105                 110         
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
        115                 120                 125             
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
    130                 135                 140                 
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
145                 150                 155                 160 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
                165                 170                 175     
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
            180                 185                 190         
Pro Pro Cys Pro Arg Cys Pro Glu Val Lys Leu Gln Glu Ser Gly Pro 
        195                 200                 205             
Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
    210                 215                 220                 
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
225                 230                 235                 240 
Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
                245                 250                 255     
Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
            260                 265                 270         
Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        275                 280                 285             
Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    290                 295                 300                 
Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
305                 310                 315                 320 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                325                 330                 335     
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            340                 345                 350         
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
        355                 360                 365             
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                405                 410                 415     
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        435                 440                 445             
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    450                 455                 460                 
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
465                 470                 475                 480 
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                485                 490                 495     
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            500                 505                 510         
Gln Ala Leu Pro Pro Arg 
        515             

<210> 117
<211> 533
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 117
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Glu Leu Lys Thr Pro 
            100                 105                 110         
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
        115                 120                 125             
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
    130                 135                 140                 
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
145                 150                 155                 160 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
                165                 170                 175     
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
            180                 185                 190         
Pro Pro Cys Pro Arg Cys Pro Glu Val Lys Leu Gln Glu Ser Gly Pro 
        195                 200                 205             
Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
    210                 215                 220                 
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
225                 230                 235                 240 
Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
                245                 250                 255     
Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
            260                 265                 270         
Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        275                 280                 285             
Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    290                 295                 300                 
Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
305                 310                 315                 320 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                325                 330                 335     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
            340                 345                 350         
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
        355                 360                 365             
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
    370                 375                 380                 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
385                 390                 395                 400 
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                405                 410                 415     
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            420                 425                 430         
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        435                 440                 445             
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    450                 455                 460                 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
465                 470                 475                 480 
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                485                 490                 495     
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            500                 505                 510         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        515                 520                 525             
Ala Leu Pro Pro Arg 
    530             

<210> 118
<211> 564
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD20_Leu16 VL_MiH5_VH_MiH3_ CD28tm+4-1BB/zeta

<400> 118
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr Pro Leu 
            100                 105                 110         
Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
        115                 120                 125             
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
        195                 200                 205             
Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
    210                 215                 220                 
Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
225                 230                 235                 240 
Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
                245                 250                 255     
Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
            260                 265                 270         
Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
        275                 280                 285             
Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
    290                 295                 300                 
Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
305                 310                 315                 320 
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
                325                 330                 335     
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            340                 345                 350         
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        355                 360                 365             
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
    370                 375                 380                 
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
385                 390                 395                 400 
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
                405                 410                 415     
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            420                 425                 430         
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        435                 440                 445             
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    450                 455                 460                 
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
465                 470                 475                 480 
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                485                 490                 495     
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            500                 505                 510         
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        515                 520                 525             
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    530                 535                 540                 
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
545                 550                 555                 560 
Leu Pro Pro Arg 
                

<210> 119
<211> 531
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_2A2 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 119
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
        115                 120                 125             
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    130                 135                 140                 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
145                 150                 155                 160 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
                165                 170                 175     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            180                 185                 190         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        195                 200                 205             
Cys Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr 
    210                 215                 220                 
Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp 
225                 230                 235                 240 
Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
                245                 250                 255     
Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
            260                 265                 270         
Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met 
        275                 280                 285             
Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr 
    290                 295                 300                 
Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys 
305                 310                 315                 320 
Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro 
                325                 330                 335     
Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp 
            340                 345                 350         
Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        355                 360                 365             
Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
    370                 375                 380                 
Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
385                 390                 395                 400 
Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                405                 410                 415     
Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             
Pro Pro Arg 
    530     

<210> 120
<211> 530
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_4-2 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 120
Gln Glu Gln Gln Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  
Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Asp His Pro Thr Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
        115                 120                 125             
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
    130                 135                 140                 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
145                 150                 155                 160 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
                165                 170                 175     
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            180                 185                 190         
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        195                 200                 205             
Pro Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly 
    210                 215                 220                 
Gln Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala 
225                 230                 235                 240 
Val His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile 
                245                 250                 255     
Tyr Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
            260                 265                 270         
Ser Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala 
        275                 280                 285             
Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr 
    290                 295                 300                 
Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Glu Leu Lys Thr 
305                 310                 315                 320 
Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys 
                325                 330                 335     
Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val 
            340                 345                 350         
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        355                 360                 365             
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             
Pro Arg 
    530 

<210> 121
<211> 562
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R11 VH_MiH5_VL_MiH3_ CD28tm+4-1BB/zeta

<400> 121
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly Ala Val Gly 
    210                 215                 220                 
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
225                 230                 235                 240 
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile 
                245                 250                 255     
Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
            260                 265                 270         
Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg 
        275                 280                 285             
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser 
    290                 295                 300                 
Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Glu Leu 
305                 310                 315                 320 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                325                 330                 335     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
            340                 345                 350         
Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys 
        355                 360                 365             
Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val 
    370                 375                 380                 
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
385                 390                 395                 400 
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
                405                 410                 415     
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            420                 425                 430         
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        435                 440                 445             
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    450                 455                 460                 
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
465                 470                 475                 480 
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                485                 490                 495     
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            500                 505                 510         
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        515                 520                 525             
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    530                 535                 540                 
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
545                 550                 555                 560 
Pro Arg 
        

<210> 122
<211> 539
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 122
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
                325                 330                 335     
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            340                 345                 350         
Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
        355                 360                 365             
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    370                 375                 380                 
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
385                 390                 395                 400 
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                405                 410                 415     
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            420                 425                 430         
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        435                 440                 445             
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    450                 455                 460                 
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
465                 470                 475                 480 
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                485                 490                 495     
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            500                 505                 510         
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        515                 520                 525             
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 

<210> 123
<211> 538
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 123
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
                325                 330                 335     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            340                 345                 350         
Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        355                 360                 365             
Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    370                 375                 380                 
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
385                 390                 395                 400 
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
                405                 410                 415     
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
            420                 425                 430         
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        435                 440                 445             
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    450                 455                 460                 
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
465                 470                 475                 480 
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                485                 490                 495     
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            500                 505                 510         
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        515                 520                 525             
Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535             

<210> 124
<211> 539
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12/V16 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 124
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
                325                 330                 335     
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            340                 345                 350         
Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
        355                 360                 365             
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    370                 375                 380                 
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
385                 390                 395                 400 
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                405                 410                 415     
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            420                 425                 430         
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        435                 440                 445             
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    450                 455                 460                 
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
465                 470                 475                 480 
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                485                 490                 495     
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            500                 505                 510         
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        515                 520                 525             
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 

<210> 125
<211> 539
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12/V20 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 125
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
                325                 330                 335     
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            340                 345                 350         
Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
        355                 360                 365             
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    370                 375                 380                 
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
385                 390                 395                 400 
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                405                 410                 415     
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            420                 425                 430         
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        435                 440                 445             
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    450                 455                 460                 
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
465                 470                 475                 480 
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                485                 490                 495     
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            500                 505                 510         
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        515                 520                 525             
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 

<210> 126
<211> 539
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12/V16-20 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 126
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg 
            260                 265                 270         
Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln 
305                 310                 315                 320 
Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
                325                 330                 335     
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            340                 345                 350         
Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
        355                 360                 365             
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    370                 375                 380                 
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
385                 390                 395                 400 
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                405                 410                 415     
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            420                 425                 430         
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        435                 440                 445             
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    450                 455                 460                 
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
465                 470                 475                 480 
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                485                 490                 495     
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            500                 505                 510         
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        515                 520                 525             
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 

<210> 127
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12/V16 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 127
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
305                 310                 315                 320 
Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
                325                 330                 335     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            340                 345                 350         
Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
    370                 375                 380                 
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             
Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         

<210> 128
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12/V20 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 128
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Asp Tyr Ile Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
305                 310                 315                 320 
Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
                325                 330                 335     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            340                 345                 350         
Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
    370                 375                 380                 
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             
Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         

<210> 129
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12/V16-20 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 129
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
        115                 120                 125             
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    130                 135                 140                 
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
145                 150                 155                 160 
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
                165                 170                 175     
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            180                 185                 190         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        195                 200                 205             
Cys Pro Arg Cys Pro Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser 
    210                 215                 220                 
Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala 
225                 230                 235                 240 
His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala Gly Gln Ala 
                245                 250                 255     
Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr Glu Lys Arg 
            260                 265                 270         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg 
        275                 280                 285             
Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr 
    290                 295                 300                 
Cys Gly Ala Glu Ser Arg Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
305                 310                 315                 320 
Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
                325                 330                 335     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            340                 345                 350         
Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
    370                 375                 380                 
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             
Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         

<210> 130
<211> 530
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_4-2 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 130
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
        115                 120                 125             
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
    130                 135                 140                 
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
145                 150                 155                 160 
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
                165                 170                 175     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            180                 185                 190         
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Asp Pro 
        195                 200                 205             
Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly Asp Thr 
    210                 215                 220                 
Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp Leu Ser 
225                 230                 235                 240 
Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr Gln 
                245                 250                 255     
Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly 
            260                 265                 270         
Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp 
        275                 280                 285             
Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser Tyr Arg 
    290                 295                 300                 
Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr 
305                 310                 315                 320 
Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys 
                325                 330                 335     
Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val 
            340                 345                 350         
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        355                 360                 365             
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             
Pro Arg 
    530 

<210> 131
<211> 531
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_X3.12 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 131
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
        115                 120                 125             
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
    130                 135                 140                 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
145                 150                 155                 160 
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
                165                 170                 175     
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            180                 185                 190         
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Asp 
        195                 200                 205             
Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly Asp 
    210                 215                 220                 
Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp Leu 
225                 230                 235                 240 
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
                245                 250                 255     
Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser 
            260                 265                 270         
Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu 
        275                 280                 285             
Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser Tyr 
    290                 295                 300                 
Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys 
305                 310                 315                 320 
Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro 
                325                 330                 335     
Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp 
            340                 345                 350         
Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        355                 360                 365             
Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
    370                 375                 380                 
Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
385                 390                 395                 400 
Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                405                 410                 415     
Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             
Pro Pro Arg 
    530     

<210> 132
<211> 530
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_ XBR2-401-DM VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 132
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Gly Arg Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
        115                 120                 125             
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
    130                 135                 140                 
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
145                 150                 155                 160 
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
                165                 170                 175     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            180                 185                 190         
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Asp Pro 
        195                 200                 205             
Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val Gly Asp Thr 
    210                 215                 220                 
Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp Leu Ser 
225                 230                 235                 240 
Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr Gln 
                245                 250                 255     
Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly 
            260                 265                 270         
Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp 
        275                 280                 285             
Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser Tyr Arg 
    290                 295                 300                 
Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr 
305                 310                 315                 320 
Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys 
                325                 330                 335     
Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val 
            340                 345                 350         
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        355                 360                 365             
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             
Pro Arg 
    530 

<210> 133
<211> 532
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.5 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 133
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    210                 215                 220                 
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp 
225                 230                 235                 240 
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
            260                 265                 270         
Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        275                 280                 285             
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser 
    290                 295                 300                 
Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu 
305                 310                 315                 320 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                325                 330                 335     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
            340                 345                 350         
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        355                 360                 365             
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             
Leu Pro Pro Arg 
    530         

<210> 134
<211> 532
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.6 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 134
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    210                 215                 220                 
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Asp 
225                 230                 235                 240 
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
            260                 265                 270         
Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        275                 280                 285             
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala Ser 
    290                 295                 300                 
Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Leu 
305                 310                 315                 320 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                325                 330                 335     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
            340                 345                 350         
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        355                 360                 365             
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             
Leu Pro Pro Arg 
    530         

<210> 135
<211> 529
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_ERCS409 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 135
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Gly 
            20                  25                  30          
Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Arg Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Tyr Tyr Gly Asp Ser Gly Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Thr Ser Val Ala Val Gly 
    210                 215                 220                 
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Trp 
225                 230                 235                 240 
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
            260                 265                 270         
Gly Arg Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Gly Val Gln Arg 
        275                 280                 285             
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Ser Pro Asn Gly Trp 
    290                 295                 300                 
Ala Phe Gly Ala Gly Thr Asn Val Glu Ile Lys Glu Leu Lys Thr Pro 
305                 310                 315                 320 
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                325                 330                 335     
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu 
            340                 345                 350         
Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        355                 360                 365             
Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    370                 375                 380                 
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
385                 390                 395                 400 
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                405                 410                 415     
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             
Arg 
    

<210> 136
<211> 532
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_huLuc63 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 136
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr 
        115                 120                 125             
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
    130                 135                 140                 
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
145                 150                 155                 160 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
                165                 170                 175     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            180                 185                 190         
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
        195                 200                 205             
Arg Cys Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    210                 215                 220                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
225                 230                 235                 240 
Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys 
                245                 250                 255     
Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
            260                 265                 270         
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        275                 280                 285             
Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser 
    290                 295                 300                 
Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Glu Leu 
305                 310                 315                 320 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                325                 330                 335     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
            340                 345                 350         
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        355                 360                 365             
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             
Leu Pro Pro Arg 
    530         

<210> 137
<211> 543
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_BV10 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 137
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Leu Lys Thr Pro 
        115                 120                 125             
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
    130                 135                 140                 
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
145                 150                 155                 160 
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
                165                 170                 175     
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            180                 185                 190         
Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
        195                 200                 205             
Pro Pro Cys Pro Arg Cys Pro Asp Ile Val Met Thr Gln Ser Pro Ser 
    210                 215                 220                 
Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
225                 230                 235                 240 
Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Met Ala Trp 
                245                 250                 255     
Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala 
            260                 265                 270         
Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        275                 280                 285             
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    290                 295                 300                 
Ala Val Tyr Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu Thr Phe Gly 
305                 310                 315                 320 
Ala Gly Thr Lys Leu Glu Leu Lys Arg Glu Leu Lys Thr Pro Leu Gly 
                325                 330                 335     
Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
            340                 345                 350         
Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val 
        355                 360                 365             
Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    370                 375                 380                 
Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
385                 390                 395                 400 
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                405                 410                 415     
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            420                 425                 430         
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        435                 440                 445             
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    450                 455                 460                 
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
465                 470                 475                 480 
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                485                 490                 495     
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            500                 505                 510         
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        515                 520                 525             
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540             

<210> 138
<211> 532
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_4G8 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 138
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
        115                 120                 125             
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    130                 135                 140                 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
145                 150                 155                 160 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
                165                 170                 175     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            180                 185                 190         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        195                 200                 205             
Cys Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr 
    210                 215                 220                 
Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 
225                 230                 235                 240 
Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 
                245                 250                 255     
Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 
            260                 265                 270         
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val 
        275                 280                 285             
Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Thr Trp 
    290                 295                 300                 
Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Glu Leu 
305                 310                 315                 320 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                325                 330                 335     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
            340                 345                 350         
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        355                 360                 365             
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             
Leu Pro Pro Arg 
    530         

<210> 139
<211> 529
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv Siglec-6_JML-1 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 139
Lys Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Gln Thr Ile Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         
Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
        115                 120                 125             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    130                 135                 140                 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
145                 150                 155                 160 
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        195                 200                 205             
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    210                 215                 220                 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
225                 230                 235                 240 
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                245                 250                 255     
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
            260                 265                 270         
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        275                 280                 285             
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
    290                 295                 300                 
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Glu Leu Lys Thr Pro 
305                 310                 315                 320 
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                325                 330                 335     
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu 
            340                 345                 350         
Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        355                 360                 365             
Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    370                 375                 380                 
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
385                 390                 395                 400 
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                405                 410                 415     
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             
Arg 
    

<210> 140
<211> 531
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v7 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 140
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Arg Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile His His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ala Ile Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
        115                 120                 125             
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    130                 135                 140                 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
145                 150                 155                 160 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
                165                 170                 175     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            180                 185                 190         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        195                 200                 205             
Cys Pro Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser Val Thr 
    210                 215                 220                 
Pro Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly 
225                 230                 235                 240 
Asn Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
                245                 250                 255     
Leu Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser Arg Phe 
            260                 265                 270         
Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
        275                 280                 285             
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp 
    290                 295                 300                 
Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys 
305                 310                 315                 320 
Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro 
                325                 330                 335     
Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp 
            340                 345                 350         
Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        355                 360                 365             
Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
    370                 375                 380                 
Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
385                 390                 395                 400 
Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                405                 410                 415     
Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             
Pro Pro Arg 
    530     

<210> 141
<211> 530
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v11 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 141
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Phe 
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Leu 
        35                  40                  45              
Gly Gly Ile Val Ala Ser Leu Gly Ser Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Asp Lys Leu Thr Ile Thr Val Asp Glu Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  
Met Glu Met Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
        115                 120                 125             
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
    130                 135                 140                 
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
145                 150                 155                 160 
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
                165                 170                 175     
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            180                 185                 190         
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        195                 200                 205             
Pro Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser Val Thr Pro 
    210                 215                 220                 
Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Thr 
225                 230                 235                 240 
Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                245                 250                 255     
Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser Arg Phe Arg 
            260                 265                 270         
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Tyr Ser Leu Glu 
        275                 280                 285             
Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro 
    290                 295                 300                 
His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr 
305                 310                 315                 320 
Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys 
                325                 330                 335     
Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val 
            340                 345                 350         
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        355                 360                 365             
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             
Pro Arg 
    530 

<210> 142
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA30 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 142
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr 
        115                 120                 125             
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
    130                 135                 140                 
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
145                 150                 155                 160 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
                165                 170                 175     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            180                 185                 190         
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
        195                 200                 205             
Arg Cys Pro Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
    210                 215                 220                 
Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
225                 230                 235                 240 
Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
                245                 250                 255     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
            260                 265                 270         
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr 
        275                 280                 285             
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
    290                 295                 300                 
Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
305                 310                 315                 320 
Glu Ile Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
                325                 330                 335     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            340                 345                 350         
Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
    370                 375                 380                 
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             
Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         

<210> 143
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA50 VH_MiH5_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 143
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr 
        115                 120                 125             
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
    130                 135                 140                 
Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
145                 150                 155                 160 
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
                165                 170                 175     
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
            180                 185                 190         
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
        195                 200                 205             
Arg Cys Pro Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
    210                 215                 220                 
Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
225                 230                 235                 240 
Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
                245                 250                 255     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
            260                 265                 270         
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        275                 280                 285             
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
    290                 295                 300                 
Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
305                 310                 315                 320 
Glu Ile Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 
                325                 330                 335     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            340                 345                 350         
Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
    370                 375                 380                 
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             
Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         

<210> 144
<211> 444
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH_Linker_VL_MiH0_ CD28tm+4-1BB/zeta

<400> 144
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 
Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
                245                 250                 255     
Thr Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
            260                 265                 270         
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        275                 280                 285             
Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    290                 295                 300                 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
305                 310                 315                 320 
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                325                 330                 335     
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            340                 345                 350         
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    370                 375                 380                 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 

<210> 145
<211> 459
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD19_FMC63 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 145
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 
Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
                245                 250                 255     
Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            260                 265                 270         
Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
        275                 280                 285             
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    290                 295                 300                 
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
305                 310                 315                 320 
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                325                 330                 335     
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            340                 345                 350         
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 

<210> 146
<211> 490
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv CD20_Leu16 VL_Linker_VH_MiH3_ CD28tm+4-1BB/zeta

<400> 146
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             
Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
    130                 135                 140                 
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp 
145                 150                 155                 160 
Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr 
                165                 170                 175     
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
            180                 185                 190         
Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
        195                 200                 205             
Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn 
    210                 215                 220                 
Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
225                 230                 235                 240 
Thr Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
                245                 250                 255     
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            260                 265                 270         
Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        275                 280                 285             
Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    290                 295                 300                 
Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 
Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 
Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 

<210> 147
<211> 454
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_2A2 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 147
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met 
    130                 135                 140                 
Ser Thr Thr Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
145                 150                 155                 160 
Asn Val Asp Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
                165                 170                 175     
Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
            180                 185                 190         
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             
Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
    210                 215                 220                 
Asp Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
                245                 250                 255     
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            260                 265                 270         
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        275                 280                 285             
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
    290                 295                 300                 
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
305                 310                 315                 320 
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                325                 330                 335     
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            340                 345                 350         
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        355                 360                 365             
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    370                 375                 380                 
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             
Gln Ala Leu Pro Pro Arg 
    450                 

<210> 148
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_4-2 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 148
Gln Glu Gln Gln Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  
Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Asp His Pro Thr Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val 
    130                 135                 140                 
Ser Leu Gly Gln Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly 
145                 150                 155                 160 
Ser Lys Ala Val His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly 
                165                 170                 175     
Leu Leu Ile Tyr Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         
Phe Ser Gly Ser Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly 
        195                 200                 205             
Ala Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
    210                 215                 220                 
Ser Ala Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Glu 
225                 230                 235                 240 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                245                 250                 255     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
            260                 265                 270         
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
        275                 280                 285             
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
    290                 295                 300                 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
305                 310                 315                 320 
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                325                 330                 335     
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
385                 390                 395                 400 
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                405                 410                 415     
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            420                 425                 430         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        435                 440                 445             
Ala Leu Pro Pro Arg 
    450             

<210> 149
<211> 485
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R11 VH_4GS3_VL_MiH3_ CD28tm+4-1BB/zeta

<400> 149
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly 
    130                 135                 140                 
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr 
                165                 170                 175     
Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly 
        195                 200                 205             
Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly 
    210                 215                 220                 
Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val 
225                 230                 235                 240 
Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg 
                245                 250                 255     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            260                 265                 270         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
        275                 280                 285             
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
    290                 295                 300                 
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
305                 310                 315                 320 
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
                325                 330                 335     
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 
Ala Leu Pro Pro Arg 
                485 

<210> 150
<211> 462
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 150
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp 
                245                 250                 255     
Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            260                 265                 270         
Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val 
        275                 280                 285             
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 
Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         

<210> 151
<211> 461
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 151
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr 
                245                 250                 255     
Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
            260                 265                 270         
Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly 
        275                 280                 285             
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    290                 295                 300                 
Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
305                 310                 315                 320 
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                325                 330                 335     
Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            340                 345                 350         
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460     

<210> 152
<211> 462
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12/V16 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 152
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp 
                245                 250                 255     
Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            260                 265                 270         
Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val 
        275                 280                 285             
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 
Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         

<210> 153
<211> 462
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12/V20 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 153
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp 
                245                 250                 255     
Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            260                 265                 270         
Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val 
        275                 280                 285             
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 
Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         

<210> 154
<211> 462
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_R12/V16-20 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 154
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly Glu Leu Lys Thr Pro Leu Gly Asp 
                245                 250                 255     
Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            260                 265                 270         
Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val 
        275                 280                 285             
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 
Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         

<210> 155
<211> 460
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12/V16 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 155
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Tyr Val Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Gln Leu Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
                245                 250                 255     
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            260                 265                 270         
Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 
Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 

<210> 156
<211> 460
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12/V20 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 156
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Tyr Val Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Gln Leu Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
                245                 250                 255     
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            260                 265                 270         
Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 
Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 

<210> 157
<211> 460
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR1_huR12/V16-20 VH_Linker_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 157
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Gly Glu Asp Leu Gly Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Ser Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Ala 
                165                 170                 175     
Gly Gln Ala Pro Arg Tyr Leu Met Tyr Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         
Glu Lys Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Ser Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Glu Ser Arg Gly Tyr Val Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Gln Leu Thr Val Gly Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
                245                 250                 255     
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            260                 265                 270         
Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 
Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 

<210> 158
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_4-2 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 158
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val 
    130                 135                 140                 
Gly Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 
Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 
                165                 170                 175     
Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
            180                 185                 190         
Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln 
        195                 200                 205             
Arg Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala 
    210                 215                 220                 
Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu 
225                 230                 235                 240 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                245                 250                 255     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
            260                 265                 270         
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
        275                 280                 285             
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
    290                 295                 300                 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
305                 310                 315                 320 
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                325                 330                 335     
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
385                 390                 395                 400 
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                405                 410                 415     
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            420                 425                 430         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        435                 440                 445             
Ala Leu Pro Pro Arg 
    450             

<210> 159
<211> 454
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_X3.12 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 159
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala 
    130                 135                 140                 
Val Gly Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser 
145                 150                 155                 160 
Ser Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu 
                165                 170                 175     
Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         
Lys Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val 
        195                 200                 205             
Gln Arg Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp 
    210                 215                 220                 
Ala Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
                245                 250                 255     
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            260                 265                 270         
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        275                 280                 285             
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
    290                 295                 300                 
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
305                 310                 315                 320 
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                325                 330                 335     
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            340                 345                 350         
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        355                 360                 365             
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    370                 375                 380                 
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             
Gln Ala Leu Pro Pro Arg 
    450                 

<210> 160
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_ XBR2-401-DM VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 160
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          
Val Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Asn Gly Arg Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Trp Thr Ser Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Thr Ser Thr Ala Val 
    130                 135                 140                 
Gly Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 
Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 
                165                 170                 175     
Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
            180                 185                 190         
Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln 
        195                 200                 205             
Arg Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gly Gly Tyr Ala Asp Ala 
    210                 215                 220                 
Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu 
225                 230                 235                 240 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                245                 250                 255     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
            260                 265                 270         
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
        275                 280                 285             
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
    290                 295                 300                 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
305                 310                 315                 320 
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                325                 330                 335     
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
385                 390                 395                 400 
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                405                 410                 415     
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            420                 425                 430         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        435                 440                 445             
Ala Leu Pro Pro Arg 
    450             

<210> 161
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.5 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 161
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Ser Ser Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Lys Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser 
        195                 200                 205             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala 
    210                 215                 220                 
Asp Ala Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 
Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg 
                245                 250                 255     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            260                 265                 270         
Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             
Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
    290                 295                 300                 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             
Met Gln Ala Leu Pro Pro Arg 
    450                 455 

<210> 162
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv ROR2_huX3.12.6 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 162
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Asn Thr Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Arg Trp Ser Leu Asn Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Pro Met Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Ser Ser Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Lys Gly Ser Gly Tyr Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser 
        195                 200                 205             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ala 
    210                 215                 220                 
Asp Ala Ser Tyr Arg Thr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 
Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg 
                245                 250                 255     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            260                 265                 270         
Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             
Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
    290                 295                 300                 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             
Met Gln Ala Leu Pro Pro Arg 
    450                 455 

<210> 163
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_ERCS409 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 163
Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Gly 
            20                  25                  30          
Val Ile Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  
Arg Ser Thr Ile Thr Arg Asn Thr Arg Leu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  
Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Tyr Tyr Gly Asp Ser Gly Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Thr Ser Val 
    130                 135                 140                 
Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Gly Ser Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Lys Gly Gly Arg Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Gly 
        195                 200                 205             
Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Ser Pro 
    210                 215                 220                 
Asn Gly Trp Ala Phe Gly Ala Gly Thr Asn Val Glu Ile Lys Glu Leu 
225                 230                 235                 240 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                245                 250                 255     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
            260                 265                 270         
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        275                 280                 285             
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
    290                 295                 300                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
305                 310                 315                 320 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                325                 330                 335     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            340                 345                 350         
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        355                 360                 365             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    370                 375                 380                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             
Leu Pro Pro Arg 
    450         

<210> 164
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv SLAMF7_huLuc63 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 164
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 
Gln Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     
Val Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
            180                 185                 190         
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 
Tyr Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 
Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg 
                245                 250                 255     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            260                 265                 270         
Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             
Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
    290                 295                 300                 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             
Met Gln Ala Leu Pro Pro Arg 
    450                 455 

<210> 165
<211> 466
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_BV10 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 165
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 
Ser Pro Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Ser 
145                 150                 155                 160 
Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
                165                 170                 175     
Met Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
            180                 185                 190         
Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
        195                 200                 205             
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
    210                 215                 220                 
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu 
225                 230                 235                 240 
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Glu Leu Lys Thr 
                245                 250                 255     
Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys 
            260                 265                 270         
Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe Trp Val 
        275                 280                 285             
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    290                 295                 300                 
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
305                 310                 315                 320 
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                325                 330                 335     
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            340                 345                 350         
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 
Pro Arg 
465     

<210> 166
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv FLT3_4G8 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 166
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 
Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 
Ser Ile Ser Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser 
                165                 170                 175     
Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro 
            180                 185                 190         
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
        195                 200                 205             
Asn Ser Val Glu Thr Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser 
    210                 215                 220                 
Asn Thr Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 
Arg Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg 
                245                 250                 255     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
            260                 265                 270         
Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             
Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
    290                 295                 300                 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             
Met Gln Ala Leu Pro Pro Arg 
    450                 455 

<210> 167
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv Siglec-6_JML-1 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 167
Lys Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Gln Thr Ile Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 
Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     
Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            180                 185                 190         
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
    210                 215                 220                 
Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Glu Leu 
225                 230                 235                 240 
Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                245                 250                 255     
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met Phe 
            260                 265                 270         
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        275                 280                 285             
Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
    290                 295                 300                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
305                 310                 315                 320 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                325                 330                 335     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            340                 345                 350         
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        355                 360                 365             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    370                 375                 380                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             
Leu Pro Pro Arg 
    450         

<210> 168
<211> 454
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v7 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 168
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Arg Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile His His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ala Ile Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln 
    130                 135                 140                 
Ser Val Thr Pro Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 
Asp Ile Gly Asn Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
                165                 170                 175     
Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro 
            180                 185                 190         
Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 
Asn Ser Trp Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
                245                 250                 255     
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            260                 265                 270         
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        275                 280                 285             
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
    290                 295                 300                 
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
305                 310                 315                 320 
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                325                 330                 335     
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            340                 345                 350         
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        355                 360                 365             
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    370                 375                 380                 
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             
Gln Ala Leu Pro Pro Arg 
    450                 

<210> 169
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv avb3_LM609v11 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 169
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Phe 
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Leu 
        35                  40                  45              
Gly Gly Ile Val Ala Ser Leu Gly Ser Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Asp Lys Leu Thr Ile Thr Val Asp Glu Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  
Met Glu Met Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asn Tyr Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Glu Phe Gln Ser 
    130                 135                 140                 
Val Thr Pro Lys Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
145                 150                 155                 160 
Ile Gly Thr Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     
Lys Leu Leu Ile Lys Tyr Ala Ser Gln Pro Val Phe Gly Val Pro Ser 
            180                 185                 190         
Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Tyr 
        195                 200                 205             
Ser Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
    210                 215                 220                 
Ser Trp Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Glu 
225                 230                 235                 240 
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
                245                 250                 255     
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Met 
            260                 265                 270         
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
        275                 280                 285             
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
    290                 295                 300                 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
305                 310                 315                 320 
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                325                 330                 335     
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
385                 390                 395                 400 
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                405                 410                 415     
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            420                 425                 430         
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        435                 440                 445             
Ala Leu Pro Pro Arg 
    450             

<210> 170
<211> 460
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA30 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 170
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 
Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala 
        195                 200                 205             
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
                245                 250                 255     
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            260                 265                 270         
Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 
Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 

<210> 171
<211> 460
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv BCMA_BCMA50 VH_4GS3_VL_MiH1_ CD28tm+4-1BB/zeta

<400> 171
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 
Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 
    210                 215                 220                 
Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr 
                245                 250                 255     
His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            260                 265                 270         
Pro Cys Pro Arg Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 
Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 

<210> 172
<211> 99
<212> PRT
<213> Artificial Sequence


<220> 
<223> CH2 domain of human IgG3

<400> 172
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          
Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val 
    50                  55                  60                  
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      
Thr Ile Ser 
            

<210> 173
<211> 99
<212> PRT
<213> Artificial Sequence


<220> 
<223> CH3 domain of human IgG3

<400> 173
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
1               5                   10                  15      
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            20                  25                  30          
Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr 
        35                  40                  45              
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    50                  55                  60                  
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys 
65                  70                  75                  80  
Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
                85                  90                  95      
Ser Leu Ser 
            

<210> 174
<211> 62
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD4tm+intracellular

<400> 174
Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      
Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            20                  25                  30          
Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr 
        35                  40                  45              
Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    50                  55                  60          

