                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       Hoffmann-La Roche Inc.
 
<120>  Method for the generation of a trivalent antibody expressing cell
        by targeted integration of multiple expression cassettes in a 
       defined organization

<130>  P35597-WO

<150>  EP19181095.1
<151>  2019-06-19

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3

<400>  1
ataacttcgt ataaagtctc ctatacgaag ttat                                   34


<210>  2
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2L

<400>  2
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  3
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  loxFas

<400>  3
acaacttcgt atataccttt ctatacgaag ttgt                                   34


<210>  4
<211>  608
<212>  DNA
<213>  Human cytomegalovirus

<400>  4
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattagc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctccg tttagtgaac      600

gtcagatc                                                               608


<210>  5
<211>  696
<212>  DNA
<213>  Human cytomegalovirus

<400>  5
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattagc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctccg tttagtgaac      600

gtcagatcta gctctgggag aggagcccag cactagaagt cggcggtgtt tccattcggt      660

gatcagcact gaacacagag gaagcttgcc gccacc                                696


<210>  6
<211>  2125
<212>  DNA
<213>  Human cytomegalovirus

<400>  6
ctgcagtgaa taataaaatg tgtgtttgtc cgaaatacgc gttttgagat ttctgtcgcc       60

gactaaattc atgtcgcgcg atagtggtgt ttatcgccga tagagatggc gatattggaa      120

aaatcgatat ttgaaaatat ggcatattga aaatgtcgcc gatgtgagtt tctgtgtaac      180

tgatatcgcc atttttccaa aagtgatttt tgggcatacg cgatatctgg cgatagcgct      240

tatatcgttt acgggggatg gcgatagacg actttggtga cttgggcgat tctgtgtgtc      300

gcaaatatcg cagtttcgat ataggtgaca gacgatatga ggctatatcg ccgatagagg      360

cgacatcaag ctggcacatg gccaatgcat atcgatctat acattgaatc aatattggcc      420

attagccata ttattcattg gttatatagc ataaatcaat attggctatt ggccattgca      480

tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc      540

atgttgacat tgattattga ctagttatta atagtaatca attacggggt cattagttca      600

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc      660

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      720

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      780

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      840

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      900

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg      960

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     1020

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     1080

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa     1140

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     1200

ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc gtgccaagag     1260

tgacgtaagt accgcctata gagtctatag gcccaccccc ttggcttctt atgcatgcta     1320

tactgttttt ggcttggggt ctatacaccc ccgcttcctc atgttatagg tgatggtata     1380

gcttagccta taggtgtggg ttattgacca ttattgacca ctcccctatt ggtgacgata     1440

ctttccatta ctaatccata acatggctct ttgccacaac tctctttatt ggctatatgc     1500

caatacactg tccttcagag actgacacgg actctgtatt tttacaggat ggggtctcat     1560

ttattattta caaattcaca tatacaacac caccgtcccc agtgcccgca gtttttatta     1620

aacataacgt gggatctcca cgcgaatctc gggtacgtgt tccggacatg ggctcttctc     1680

cggtagcggc ggagcttcta catccgagcc ctgctcccat gcctccagcg actcatggtc     1740

gctcggcagc tccttgctcc taacagtgga ggccagactt aggcacagca cgatgcccac     1800

caccaccagt gtgccgcaca aggccgtggc ggtagggtat gtgtctgaaa atgagctcgg     1860

ggagcgggct tgcaccgctg acgcatttgg aagacttaag gcagcggcag aagaagatgc     1920

aggcagctga gttgttgtgt tctgataaga gtcagaggta actcccgttg cggtgctgtt     1980

aacggtggag ggcagtgtag tctgagcagt actcgttgct gccgcgcgcg ccaccagaca     2040

taatagctga cagactaaca gactgttcct ttccatgggt cttttctgca gtcaccgtcc     2100

ttgacacggt ttaaacgccg ccacc                                           2125


<210>  7
<211>  129
<212>  DNA
<213>  Simian virus 40

<400>  7
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcacc attctagttg tggtttgtcc aaactcatca atgtatctta      120

tcatgtctg                                                              129


<210>  8
<211>  225
<212>  DNA
<213>  Bos taurus

<400>  8
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  9
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  9
caggataata tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta       60

ttttattttt gag                                                          73


<210>  10
<211>  288
<212>  DNA
<213>  Simian virus 40

<400>  10
agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca       60

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa      120

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag      180

aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag      240

gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcg                   288


<210>  11
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  green fluorescent protein encoding nucleic acid

<400>  11
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtcc      720

ggactcagat ctcgagctca agcttcgaat tctgcagtcg acggtaccgc gggcccggga      780

tccaccggat ctagatga                                                    798


