                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> ENGINEERED HUMAN-ENDOGENOUS VIRUS-LIKE PARTICLES AND METHODS OF 
      USE THEREOF FOR DELIVERY TO CELLS

<130> 29539-0385WO1

<140> PCT/US2020/037740
<141> 2020-06-15

<150> 62/861,186
<151> 2019-06-13

<160> 123   

<170> PatentIn version 3.5

<210> 1
<211> 396
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Leu Asp His Arg Thr Ser Gly Gly Leu His Ala Tyr Pro Gly 
1               5                   10                  15      


Pro Arg Gly Gly Gln Val Ala Lys Pro Asn Val Ile Leu Gln Ile Gly 
            20                  25                  30          


Lys Cys Arg Ala Glu Met Leu Glu His Val Arg Arg Thr His Arg His 
        35                  40                  45              


Leu Leu Ala Glu Val Ser Lys Gln Val Glu Arg Glu Leu Lys Gly Leu 
    50                  55                  60                  


His Arg Ser Val Gly Lys Leu Glu Ser Asn Leu Asp Gly Tyr Val Pro 
65                  70                  75                  80  


Thr Ser Asp Ser Gln Arg Trp Lys Lys Ser Ile Lys Ala Cys Leu Cys 
                85                  90                  95      


Arg Cys Gln Glu Thr Ile Ala Asn Leu Glu Arg Trp Val Lys Arg Glu 
            100                 105                 110         


Met His Val Trp Arg Glu Val Phe Tyr Arg Leu Glu Arg Trp Ala Asp 
        115                 120                 125             


Arg Leu Glu Ser Thr Gly Gly Lys Tyr Pro Val Gly Ser Glu Ser Ala 
    130                 135                 140                 


Arg His Thr Val Ser Val Gly Val Gly Gly Pro Glu Ser Tyr Cys His 
145                 150                 155                 160 


Glu Ala Asp Gly Tyr Asp Tyr Thr Val Ser Pro Tyr Ala Ile Thr Pro 
                165                 170                 175     


Pro Pro Ala Ala Gly Glu Leu Pro Gly Gln Glu Pro Ala Glu Ala Gln 
            180                 185                 190         


Gln Tyr Gln Pro Trp Val Pro Gly Glu Asp Gly Gln Pro Ser Pro Gly 
        195                 200                 205             


Val Asp Thr Gln Ile Phe Glu Asp Pro Arg Glu Phe Leu Ser His Leu 
    210                 215                 220                 


Glu Glu Tyr Leu Arg Gln Val Gly Gly Ser Glu Glu Tyr Trp Leu Ser 
225                 230                 235                 240 


Gln Ile Gln Asn His Met Asn Gly Pro Ala Lys Lys Trp Trp Glu Phe 
                245                 250                 255     


Lys Gln Gly Ser Val Lys Asn Trp Val Glu Phe Lys Lys Glu Phe Leu 
            260                 265                 270         


Gln Tyr Ser Glu Gly Thr Leu Ser Arg Glu Ala Ile Gln Arg Glu Leu 
        275                 280                 285             


Asp Leu Pro Gln Lys Gln Gly Glu Pro Leu Asp Gln Phe Leu Trp Arg 
    290                 295                 300                 


Lys Arg Asp Leu Tyr Gln Thr Leu Tyr Val Asp Ala Asp Glu Glu Glu 
305                 310                 315                 320 


Ile Ile Gln Tyr Val Val Gly Thr Leu Gln Pro Lys Leu Lys Arg Phe 
                325                 330                 335     


Leu Arg His Pro Leu Pro Lys Thr Leu Glu Gln Leu Ile Gln Arg Gly 
            340                 345                 350         


Met Glu Val Gln Asp Asp Leu Glu Gln Ala Ala Glu Pro Ala Gly Pro 
        355                 360                 365             


His Leu Pro Val Glu Asp Glu Ala Glu Thr Leu Thr Pro Ala Pro Asn 
    370                 375                 380                 


Ser Glu Ser Val Ala Ser Asp Arg Thr Gln Pro Glu 
385                 390                 395     


<210> 2
<211> 584
<212> PRT
<213> Homo sapiens

<400> 2
Met Ile Phe Ala Gly Lys Ala Pro Ser Asn Thr Ser Thr Leu Met Lys 
1               5                   10                  15      


Phe Tyr Ser Leu Leu Leu Tyr Ser Leu Leu Phe Ser Phe Pro Phe Leu 
            20                  25                  30          


Cys His Pro Leu Pro Leu Pro Ser Tyr Leu His His Thr Ile Asn Leu 
        35                  40                  45              


Thr His Ser Leu Leu Ala Ala Ser Asn Pro Ser Leu Val Asn Asn Cys 
    50                  55                  60                  


Trp Leu Cys Ile Ser Leu Ser Ser Ser Ala Tyr Thr Ala Val Pro Ala 
65                  70                  75                  80  


Val Gln Thr Asp Trp Ala Thr Ser Pro Ile Ser Leu His Leu Arg Thr 
                85                  90                  95      


Ser Phe Asn Ser Pro His Leu Tyr Pro Pro Glu Glu Leu Ile Tyr Phe 
            100                 105                 110         


Leu Asp Arg Ser Ser Lys Thr Ser Pro Asp Ile Ser His Gln Gln Ala 
        115                 120                 125             


Ala Ala Leu Leu Arg Thr Tyr Leu Lys Asn Leu Ser Pro Tyr Ile Asn 
    130                 135                 140                 


Ser Thr Pro Pro Ile Phe Gly Pro Leu Thr Thr Gln Thr Thr Ile Pro 
145                 150                 155                 160 


Val Ala Ala Pro Leu Cys Ile Ser Trp Gln Arg Pro Thr Gly Ile Pro 
                165                 170                 175     


Leu Gly Asn Leu Ser Pro Ser Arg Cys Ser Phe Thr Leu His Leu Arg 
            180                 185                 190         


Ser Pro Thr Thr Asn Ile Asn Glu Thr Ile Gly Ala Phe Gln Leu His 
        195                 200                 205             


Ile Thr Asp Lys Pro Ser Ile Asn Thr Asp Lys Leu Lys Asn Ile Ser 
    210                 215                 220                 


Ser Asn Tyr Cys Leu Gly Arg His Leu Pro Cys Ile Ser Leu His Pro 
225                 230                 235                 240 


Trp Leu Ser Ser Pro Cys Ser Ser Asp Ser Pro Pro Arg Pro Ser Ser 
                245                 250                 255     


Cys Leu Leu Ile Pro Ser Pro Glu Asn Asn Ser Glu Arg Leu Leu Val 
            260                 265                 270         


Asp Thr Arg Arg Phe Leu Ile His His Glu Asn Arg Thr Phe Pro Ser 
        275                 280                 285             


Thr Gln Leu Pro His Gln Ser Pro Leu Gln Pro Leu Thr Ala Ala Ala 
    290                 295                 300                 


Leu Ala Gly Ser Leu Gly Val Trp Val Gln Asp Thr Pro Phe Ser Thr 
305                 310                 315                 320 


Pro Ser His Leu Phe Thr Leu His Leu Gln Phe Cys Leu Ala Gln Gly 
                325                 330                 335     


Leu Phe Phe Leu Cys Gly Ser Ser Thr Tyr Met Cys Leu Pro Ala Asn 
            340                 345                 350         


Trp Thr Gly Thr Cys Thr Leu Val Phe Leu Thr Pro Lys Ile Gln Phe 
        355                 360                 365             


Ala Asn Gly Thr Glu Glu Leu Pro Val Pro Leu Met Thr Pro Thr Gln 
    370                 375                 380                 


Gln Lys Arg Val Ile Pro Leu Ile Pro Leu Met Val Gly Leu Gly Leu 
385                 390                 395                 400 


Ser Ala Ser Thr Val Ala Leu Gly Thr Gly Ile Ala Gly Ile Ser Thr 
                405                 410                 415     


Ser Val Met Thr Phe Arg Ser Leu Ser Asn Asp Phe Ser Ala Ser Ile 
            420                 425                 430         


Thr Asp Ile Ser Gln Thr Leu Ser Val Leu Gln Ala Gln Val Asp Ser 
        435                 440                 445             


Leu Ala Ala Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Thr 
    450                 455                 460                 


Ala Glu Lys Gly Gly Leu Cys Ile Phe Leu Asn Glu Glu Cys Cys Phe 
465                 470                 475                 480 


Tyr Leu Asn Gln Ser Gly Leu Val Tyr Asp Asn Ile Lys Lys Leu Lys 
                485                 490                 495     


Asp Arg Ala Gln Lys Leu Ala Asn Gln Ala Ser Asn Tyr Ala Glu Pro 
            500                 505                 510         


Pro Trp Ala Leu Ser Asn Trp Met Ser Trp Val Leu Pro Ile Val Ser 
        515                 520                 525             


Pro Leu Ile Pro Ile Phe Leu Leu Leu Leu Phe Gly Pro Cys Ile Phe 
    530                 535                 540                 


Arg Leu Val Ser Gln Phe Ile Gln Asn Arg Ile Gln Ala Ile Thr Asn 
545                 550                 555                 560 


His Ser Ile Arg Gln Met Phe Leu Leu Thr Ser Pro Gln Tyr His Pro 
                565                 570                 575     


Leu Pro Gln Asp Leu Pro Ser Ala 
            580                 


<210> 3
<211> 563
<212> PRT
<213> Homo sapiens

<400> 3
Met Ile Phe Ala Gly Arg Ala Ser Ser Asn Thr Ser Thr Leu Met Lys 
1               5                   10                  15      


Phe Tyr Ser Leu Leu Leu Tyr Ser Leu Leu Phe Ser Phe Pro Ile Leu 
            20                  25                  30          


Cys His Pro Leu Pro Leu Pro Ser Tyr Leu His His Thr Ile Asn Leu 
        35                  40                  45              


Thr His Ser Leu Leu Ala Val Ser Asn Pro Ser Leu Ala Lys Asn Cys 
    50                  55                  60                  


Trp Leu Cys Ile Ser Leu Pro Ser Ser Ala Tyr Pro Ala Val Pro Ala 
65                  70                  75                  80  


Leu Gln Thr Asp Trp Gly Thr Ser Pro Val Ser Pro His Leu Arg Thr 
                85                  90                  95      


Ser Phe Asn Ser Pro His Leu Tyr Pro Pro Glu Lys Leu Ile Tyr Phe 
            100                 105                 110         


Leu Asp Arg Ser Ser Lys Thr Ser Pro Asp Ile Ser His Gln Gln Ala 
        115                 120                 125             


Ala Ala Leu Leu Cys Thr Tyr Leu Lys Asn Leu Ser Pro Tyr Ile Asn 
    130                 135                 140                 


Ser Thr Pro Pro Thr Phe Gly Pro Leu Thr Thr Gln Thr Thr Ile Pro 
145                 150                 155                 160 


Val Ala Ala Pro Leu Cys Ile Ser Arg Gln Arg Pro Thr Gly Ile Pro 
                165                 170                 175     


Leu Gly Asn Leu Ser Pro Ser Arg Cys Ser Phe Thr Leu His Leu Arg 
            180                 185                 190         


Ser Pro Thr Thr His Ile Thr Glu Thr Asn Gly Ala Phe Gln Leu His 
        195                 200                 205             


Ile Thr Asp Lys Pro Ser Ile Asn Thr Asp Lys Leu Lys Asn Val Ser 
    210                 215                 220                 


Ser Asn Tyr Cys Leu Gly Arg His Leu Ser Cys Ile Ser Leu His Pro 
225                 230                 235                 240 


Trp Leu Phe Ser Pro Cys Ser Ser Asp Ser Pro Pro Arg Pro Ser Ser 
                245                 250                 255     


Cys Leu Leu Ile Pro Ser Pro Lys Asn Asn Ser Glu Ser Leu Leu Val 
            260                 265                 270         


Asp Ala Gln Arg Phe Leu Ile Tyr His Glu Asn Arg Thr Ser Pro Ser 
        275                 280                 285             


Thr Gln Leu Pro His Gln Ser Pro Leu Gln Pro Leu Thr Ala Ala Pro 
    290                 295                 300                 


Leu Gly Gly Ser Leu Arg Val Trp Val Gln Asp Thr Pro Phe Ser Thr 
305                 310                 315                 320 


Pro Ser His Leu Phe Thr Leu His Leu Gln Phe Cys Leu Val Gln Ser 
                325                 330                 335     


Leu Phe Phe Leu Cys Gly Ser Ser Thr Tyr Met Cys Leu Pro Ala Asn 
            340                 345                 350         


Trp Thr Gly Thr Cys Thr Leu Val Phe Leu Thr Ser Lys Ile Gln Phe 
        355                 360                 365             


Ala Asn Gly Thr Glu Glu Leu Pro Val Pro Leu Met Thr Pro Thr Arg 
    370                 375                 380                 


Gln Lys Arg Val Ile Pro Leu Ile Pro Leu Met Val Gly Leu Gly Leu 
385                 390                 395                 400 


Ser Ala Ser Thr Val Ala Leu Gly Thr Gly Ile Ala Gly Ile Ser Thr 
                405                 410                 415     


Ser Val Thr Thr Phe Arg Ile Leu Ser Asn Asp Phe Ser Ala Ser Ile 
            420                 425                 430         


Thr Asp Ile Ser Gln Thr Leu Ser Gly Leu Gln Ala Gln Val Asp Ser 
        435                 440                 445             


Ser Ala Ala Val Val Leu Gln Asn Arg Gln Gly Leu Asp Leu Leu Thr 
    450                 455                 460                 


Ala Glu Lys Gly Gly Leu Cys Ile Phe Leu Asn Glu Glu Ser Tyr Phe 
465                 470                 475                 480 


Tyr Leu Asn Gln Ser Gly Leu Val Tyr Asp Asn Ile Lys Lys Leu Lys 
                485                 490                 495     


Asp Lys Ala Gln Asn Leu Ala Asn Gln Ala Ser Asn Tyr Ala Glu Pro 
            500                 505                 510         


Pro Trp Pro Leu Ser Asn Trp Met Ser Trp Val Leu Pro Ile Leu Ser 
        515                 520                 525             


Pro Leu Ile Pro Ile Phe Leu Leu Leu Phe Phe Arg Pro Cys Ile Phe 
    530                 535                 540                 


His Leu Val Ser Gln Phe Ile Gln Asn His Ile Gln Ala Ile Thr Asp 
545                 550                 555                 560 


His Ser Ile 
            


<210> 4
<211> 555
<212> PRT
<213> Homo sapiens

<400> 4
Met Ile Leu Ala Gly Arg Ala Pro Ser Asn Thr Ser Thr Leu Met Lys 
1               5                   10                  15      


Phe Tyr Ser Leu Leu Leu Tyr Ser Leu Leu Phe Ser Phe Pro Phe Leu 
            20                  25                  30          


Tyr His Pro Leu Pro Leu Pro Ser Tyr Leu His His Thr Ile Asn Leu 
        35                  40                  45              


Thr His Ser Leu Pro Ala Ala Ser Asn Pro Ser Leu Ala Asn Asn Cys 
    50                  55                  60                  


Trp Leu Cys Ile Ser Leu Ser Ser Ser Ala Tyr Ile Ala Val Pro Thr 
65                  70                  75                  80  


Leu Gln Thr Asp Arg Ala Thr Ser Pro Val Ser Leu His Leu Arg Thr 
                85                  90                  95      


Ser Phe Asn Ser Pro His Leu Tyr Pro Pro Glu Glu Leu Ile Tyr Phe 
            100                 105                 110         


Leu Asp Arg Ser Ser Lys Thr Ser Pro Asp Ile Ser His Gln Pro Ala 
        115                 120                 125             


Ala Ala Leu Leu His Ile Tyr Leu Lys Asn Leu Ser Pro Tyr Ile Asn 
    130                 135                 140                 


Ser Thr Pro Pro Ile Phe Gly Pro Leu Thr Thr Gln Thr Thr Ile Pro 
145                 150                 155                 160 


Val Ala Ala Pro Leu Cys Ile Ser Arg Gln Arg Pro Thr Gly Ile Pro 
                165                 170                 175     


Leu Gly Asn Ile Ser Pro Ser Arg Cys Ser Phe Thr Leu His Leu Gln 
            180                 185                 190         


Ser Pro Thr Thr His Val Thr Glu Thr Ile Gly Val Phe Gln Leu His 
        195                 200                 205             


Ile Ile Asp Lys Pro Ser Ile Asn Thr Asp Lys Leu Lys Asn Val Ser 
    210                 215                 220                 


Ser Asn Tyr Cys Leu Gly Arg His Leu Pro Tyr Ile Ser Leu His Pro 
225                 230                 235                 240 


Trp Leu Pro Ser Pro Cys Ser Ser Asp Ser Pro Pro Arg Pro Ser Ser 
                245                 250                 255     


Cys Leu Leu Thr Pro Ser Pro Gln Asn Asn Ser Glu Arg Leu Leu Val 
            260                 265                 270         


Asp Thr Gln Arg Phe Leu Ile His His Glu Asn Arg Thr Ser Ser Ser 
        275                 280                 285             


Met Gln Leu Ala His Gln Ser Pro Leu Gln Pro Leu Thr Ala Ala Ala 
    290                 295                 300                 


Leu Ala Gly Ser Leu Gly Val Trp Val Gln Asp Thr Pro Phe Ser Thr 
305                 310                 315                 320 


Pro Ser His Pro Phe Ser Leu His Leu Gln Phe Cys Leu Thr Gln Gly 
                325                 330                 335     


Leu Phe Phe Leu Cys Gly Ser Ser Thr Tyr Met Cys Leu Pro Ala Asn 
            340                 345                 350         


Trp Thr Gly Thr Cys Thr Leu Val Phe Leu Thr Pro Lys Ile Gln Phe 
        355                 360                 365             


Ala Asn Gly Thr Lys Glu Leu Pro Val Pro Leu Met Thr Leu Thr Pro 
    370                 375                 380                 


Gln Lys Arg Val Ile Pro Leu Ile Pro Leu Met Val Gly Leu Gly Leu 
385                 390                 395                 400 


Ser Ala Ser Thr Ile Ala Leu Ser Thr Gly Ile Ala Gly Ile Ser Thr 
                405                 410                 415     


Ser Val Thr Thr Phe Arg Ser Pro Ser Asn Asp Phe Ser Ala Ser Ile 
            420                 425                 430         


Thr Asp Ile Ser Gln Thr Leu Ser Val Leu Gln Ala Gln Val Asp Ser 
        435                 440                 445             


Leu Ala Ala Val Val Leu Gln Asn Arg Arg Gly Leu Gly Leu Ser Ile 
    450                 455                 460                 


Leu Leu Asn Glu Glu Cys Cys Phe Tyr Leu Asn Gln Ser Gly Leu Val 
465                 470                 475                 480 


Tyr Glu Asn Ile Lys Lys Leu Lys Asp Arg Ala Gln Lys Leu Ala Asn 
                485                 490                 495     


Gln Ala Ser Asn Tyr Ala Glu Ser Pro Trp Ala Leu Ser Asn Trp Met 
            500                 505                 510         


Ser Trp Val Leu Pro Ile Leu Ser Pro Leu Ile Pro Ile Phe Leu Leu 
        515                 520                 525             


Leu Leu Phe Gly Pro Cys Ile Phe His Leu Val Ser Gln Phe Ile Gln 
    530                 535                 540                 


Asn Arg Ile Gln Ala Ile Thr Asn His Ser Ile 
545                 550                 555 


<210> 5
<211> 698
<212> PRT
<213> Homo sapiens

<400> 5
Met His Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro Thr 
        35                  40                  45              


Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu Glu 
    50                  55                  60                  


Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala Leu 
65                  70                  75                  80  


Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala Ala 
                85                  90                  95      


Ala Ala Asn Tyr Thr Asn Trp Ala Tyr Val Pro Phe Pro Pro Leu Ile 
            100                 105                 110         


Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn Asp 
        115                 120                 125             


Ser Val Trp Val His Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys Pro 
    130                 135                 140                 


Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr His Tyr Pro 
145                 150                 155                 160 


Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val Gln 
                165                 170                 175     


Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe Thr 
            180                 185                 190         


Tyr Asn Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr Leu 
        195                 200                 205             


Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly Lys 
    210                 215                 220                 


Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val Leu 
225                 230                 235                 240 


Val Trp Glu Glu Cys Val Ala Asn Ser Val Val Ile Leu Gln Asn Asn 
                245                 250                 255     


Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr His 
            260                 265                 270         


Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser Pro 
        275                 280                 285             


Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His Lys 
    290                 295                 300                 


Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile Ser 
305                 310                 315                 320 


Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His Pro 
                325                 330                 335     


Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp Ser 
            340                 345                 350         


Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr Val 
        355                 360                 365             


Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys Pro 
    370                 375                 380                 


Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser Gln 
385                 390                 395                 400 


Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser Thr 
                405                 410                 415     


Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly Val 
            420                 425                 430         


Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser Ile 
        435                 440                 445             


His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys Arg 
    450                 455                 460                 


Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val Thr 
465                 470                 475                 480 


Ala Met Ala Ala Val Ala Gly Val Ala Leu His Ser Phe Val Gln Ser 
                485                 490                 495     


Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp Asn 
            500                 505                 510         


Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp Leu 
        515                 520                 525             


Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu His 
    530                 535                 540                 


Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile Thr 
545                 550                 555                 560 


Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg Arg 
                565                 570                 575     


His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys Leu 
            580                 585                 590         


Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val Pro 
        595                 600                 605             


Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu Asn 
    610                 615                 620                 


Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn Leu 
625                 630                 635                 640 


Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg Phe 
                645                 650                 655     


Thr Gln Gln Leu Arg Arg Asp Ser Tyr His Arg Glu Arg Ala Met Met 
            660                 665                 670         


Thr Met Val Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys Ser 
        675                 680                 685             


Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695             


<210> 6
<211> 699
<212> PRT
<213> Homo sapiens

<400> 6
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Thr Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr His Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Cys Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 


Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Ile Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             


Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 


Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 


Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     


Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         


Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             


Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 


His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 


Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     


Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         


Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             


Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 


Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 


Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     


Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         


Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             


Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 


<210> 7
<211> 699
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Thr Asp Asp His Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Phe Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 


Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Val Asp Leu Asn Ser Ser Val Thr Val Pro Leu Gln Ser Cys Ile Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Thr Ser Pro Ser 
        435                 440                 445             


Ile His Thr Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 


Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 


Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     


Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         


Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             


Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 


His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Ser Ile 
545                 550                 555                 560 


Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     


Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         


Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             


Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 


Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 


Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     


Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         


Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             


Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 


<210> 8
<211> 698
<212> PRT
<213> Homo sapiens

<400> 8
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Asn Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val Gln 
                165                 170                 175     


Asn Trp Leu Val Glu Val Pro Ile Val Ser Pro Ile Cys Arg Phe Thr 
            180                 185                 190         


Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr Leu 
        195                 200                 205             


Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly Lys 
    210                 215                 220                 


Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val Leu 
225                 230                 235                 240 


Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn Asn 
                245                 250                 255     


Glu Phe Gly Thr Ile Ile Asp Trp Thr Pro Gln Gly Gln Phe Tyr His 
            260                 265                 270         


Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser Pro 
        275                 280                 285             


Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His Lys 
    290                 295                 300                 


Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile Ser 
305                 310                 315                 320 


Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His Pro 
                325                 330                 335     


Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp Ser 
            340                 345                 350         


Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr Val 
        355                 360                 365             


Asp Leu Asn Ser Ser Leu Thr Leu Pro Leu Gln Ser Cys Val Lys Pro 
    370                 375                 380                 


Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser Gln 
385                 390                 395                 400 


Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser Thr 
                405                 410                 415     


Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly Val 
            420                 425                 430         


Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser Ile 
        435                 440                 445             


His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys Arg 
    450                 455                 460                 


Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val Thr 
465                 470                 475                 480 


Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln Ser 
                485                 490                 495     


Val Asn Phe Val Asn Asp Gly Gln Lys Asn Ser Thr Arg Leu Trp Asn 
            500                 505                 510         


Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp Leu 
        515                 520                 525             


Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu His 
    530                 535                 540                 


Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile Thr 
545                 550                 555                 560 


Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg Arg 
                565                 570                 575     


His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys Leu 
            580                 585                 590         


Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val Pro 
        595                 600                 605             


Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu Asn 
    610                 615                 620                 


Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn Leu 
625                 630                 635                 640 


Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg Cys 
                645                 650                 655     


Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met Met 
            660                 665                 670         


Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys Ser 
        675                 680                 685             


Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695             


<210> 9
<211> 699
<212> PRT
<213> Homo sapiens

<400> 9
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Ile Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Thr Asp Asp Cys Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Leu Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 


Ser Thr Ala Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Ile Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             


Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 


Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 


Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     


Ser Val Asn Phe Val Asn Asp Trp Gln Asn Asn Ser Thr Arg Leu Trp 
            500                 505                 510         


Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             


Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 


His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 


Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     


Cys His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         


Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             


Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 


Asn Thr Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 


Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Tyr Arg 
                645                 650                 655     


Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         


Met Thr Met Val Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             


Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 


<210> 10
<211> 699
<212> PRT
<213> Homo sapiens

<400> 10
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Val Ala Asn Tyr Thr Asn Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Arg Ile 
305                 310                 315                 320 


Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Val Asp Leu Asn Ser Ser Leu Thr Leu Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             


Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 


Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 


Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     


Ser Val Asn Phe Val Asn Asp Gly Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         


Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             


Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 


His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 


Thr Pro Gln Ile Tyr Asn Asp Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     


Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         


Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             


Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 


Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 


Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     


Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         


Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             


Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 


<210> 11
<211> 626
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Pro Glu Ala Trp Val Arg Pro Leu Lys Thr Ala Pro Lys Pro 
1               5                   10                  15      


Gly Glu Ala Ile Arg Leu Ile Leu Phe Ile Tyr Leu Ser Cys Phe Phe 
            20                  25                  30          


Leu Pro Val Met Ser Ser Glu Pro Ser Tyr Ser Phe Leu Leu Thr Ser 
        35                  40                  45              


Phe Thr Thr Gly Arg Val Phe Ala Asn Thr Thr Trp Arg Ala Gly Thr 
    50                  55                  60                  


Ser Lys Glu Val Ser Phe Ala Val Asp Leu Cys Val Leu Phe Pro Glu 
65                  70                  75                  80  


Pro Ala Arg Thr His Glu Glu Gln His Asn Leu Pro Val Ile Gly Ala 
                85                  90                  95      


Gly Ser Val Asp Leu Ala Ala Gly Phe Gly His Ser Gly Ser Gln Thr 
            100                 105                 110         


Gly Cys Gly Ser Ser Lys Gly Ala Glu Lys Gly Leu Gln Asn Val Asp 
        115                 120                 125             


Phe Tyr Leu Cys Pro Gly Asn His Pro Asp Ala Ser Cys Arg Asp Thr 
    130                 135                 140                 


Tyr Gln Phe Phe Cys Pro Asp Trp Thr Cys Val Thr Leu Ala Thr Tyr 
145                 150                 155                 160 


Ser Gly Gly Ser Thr Arg Ser Ser Thr Leu Ser Ile Ser Arg Val Pro 
                165                 170                 175     


His Pro Lys Leu Cys Thr Arg Lys Asn Cys Asn Pro Leu Thr Ile Thr 
            180                 185                 190         


Val His Asp Pro Asn Ala Ala Gln Trp Tyr Tyr Gly Met Ser Trp Gly 
        195                 200                 205             


Leu Arg Leu Tyr Ile Pro Gly Phe Asp Val Gly Thr Met Phe Thr Ile 
    210                 215                 220                 


Gln Lys Lys Ile Leu Val Ser Trp Ser Ser Pro Lys Pro Ile Gly Pro 
225                 230                 235                 240 


Leu Thr Asp Leu Gly Asp Pro Ile Phe Gln Lys His Pro Asp Lys Val 
                245                 250                 255     


Asp Leu Thr Val Pro Leu Pro Phe Leu Val Pro Arg Pro Gln Leu Gln 
            260                 265                 270         


Gln Gln His Leu Gln Pro Ser Leu Met Ser Ile Leu Gly Gly Val His 
        275                 280                 285             


His Leu Leu Asn Leu Thr Gln Pro Lys Leu Ala Gln Asp Cys Trp Leu 
    290                 295                 300                 


Cys Leu Lys Ala Lys Pro Pro Tyr Tyr Val Gly Leu Gly Val Glu Ala 
305                 310                 315                 320 


Thr Leu Lys Arg Gly Pro Leu Ser Cys His Thr Arg Pro Arg Ala Leu 
                325                 330                 335     


Thr Ile Gly Asp Val Ser Gly Asn Ala Ser Cys Leu Ile Ser Thr Gly 
            340                 345                 350         


Tyr Asn Leu Ser Ala Ser Pro Phe Gln Ala Thr Cys Asn Gln Ser Leu 
        355                 360                 365             


Leu Thr Ser Ile Ser Thr Ser Val Ser Tyr Gln Ala Pro Asn Asn Thr 
    370                 375                 380                 


Trp Leu Ala Cys Thr Ser Gly Leu Thr Arg Cys Ile Asn Gly Thr Glu 
385                 390                 395                 400 


Pro Gly Pro Leu Leu Cys Val Leu Val His Val Leu Pro Gln Val Tyr 
                405                 410                 415     


Val Tyr Ser Gly Pro Glu Gly Arg Gln Leu Ile Ala Pro Pro Glu Leu 
            420                 425                 430         


His Pro Arg Leu His Gln Ala Val Pro Leu Leu Val Pro Leu Leu Ala 
        435                 440                 445             


Gly Leu Ser Ile Ala Gly Ser Ala Ala Ile Gly Thr Ala Ala Leu Val 
    450                 455                 460                 


Gln Gly Glu Thr Gly Leu Ile Ser Leu Ser Gln Gln Val Asp Ala Asp 
465                 470                 475                 480 


Phe Ser Asn Leu Gln Ser Ala Ile Asp Ile Leu His Ser Gln Val Glu 
                485                 490                 495     


Ser Leu Ala Glu Val Val Leu Gln Asn Cys Arg Cys Leu Asp Leu Leu 
            500                 505                 510         


Phe Leu Ser Gln Gly Gly Leu Cys Ala Ala Leu Gly Glu Ser Cys Cys 
        515                 520                 525             


Phe Tyr Ala Asn Gln Ser Gly Val Ile Lys Gly Thr Val Lys Lys Val 
    530                 535                 540                 


Arg Glu Asn Leu Asp Arg His Gln Gln Glu Arg Glu Asn Asn Ile Pro 
545                 550                 555                 560 


Trp Tyr Gln Ser Met Phe Asn Trp Asn Pro Trp Leu Thr Thr Leu Ile 
                565                 570                 575     


Thr Gly Leu Ala Gly Pro Leu Leu Ile Leu Leu Leu Ser Leu Ile Phe 
            580                 585                 590         


Gly Pro Cys Ile Leu Asn Ser Phe Leu Asn Phe Ile Lys Gln Arg Ile 
        595                 600                 605             


Ala Ser Val Lys Leu Thr Tyr Leu Lys Thr Gln Tyr Asp Thr Leu Val 
    610                 615                 620                 


Asn Asn 
625     


<210> 12
<211> 538
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          


Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              


Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  


His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  


His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      


Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         


Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             


Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 


Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 


His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     


Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys Leu Pro Leu 
            180                 185                 190         


Asn Phe Arg Pro Tyr Val Ser Ile Pro Val Pro Glu Gln Trp Asn Asn 
        195                 200                 205             


Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu Val Gly Pro Leu Val 
    210                 215                 220                 


Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Cys Val Lys Phe 
225                 230                 235                 240 


Ser Asn Thr Thr Tyr Thr Thr Asn Ser Gln Cys Ile Arg Trp Val Thr 
                245                 250                 255     


Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly Ile Phe Phe Val Cys 
            260                 265                 270         


Gly Thr Ser Ala Tyr Arg Cys Leu Asn Gly Ser Ser Glu Ser Met Cys 
        275                 280                 285             


Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp 
    290                 295                 300                 


Leu Tyr Ser Tyr Val Ile Ser Lys Pro Arg Asn Lys Arg Val Pro Ile 
305                 310                 315                 320 


Leu Pro Phe Val Ile Gly Ala Gly Val Leu Gly Ala Leu Gly Thr Gly 
                325                 330                 335     


Ile Gly Gly Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln 
            340                 345                 350         


Glu Leu Asn Gly Asp Met Glu Arg Val Ala Asp Ser Leu Val Thr Leu 
        355                 360                 365             


Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg 
    370                 375                 380                 


Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly Gly Thr Cys Leu Phe Leu 
385                 390                 395                 400 


Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln Ser Gly Ile Val Thr Glu 
                405                 410                 415     


Lys Val Lys Glu Ile Arg Asp Arg Ile Gln Arg Arg Ala Glu Glu Leu 
            420                 425                 430         


Arg Asn Thr Gly Pro Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Ile 
        435                 440                 445             


Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile Ile Leu Leu Leu Leu Phe 
    450                 455                 460                 


Gly Pro Cys Ile Phe Asn Leu Leu Val Asn Phe Val Ser Ser Arg Ile 
465                 470                 475                 480 


Glu Ala Val Lys Leu Gln Met Glu Pro Lys Met Gln Ser Lys Thr Lys 
                485                 490                 495     


Ile Tyr Arg Arg Pro Leu Asp Arg Pro Ala Ser Pro Arg Ser Asp Val 
            500                 505                 510         


Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu Ile Ser Ala Ala Gln Pro 
        515                 520                 525             


Leu Leu Arg Pro Asn Ser Ala Gly Ser Ser 
    530                 535             


<210> 13
<211> 538
<212> PRT
<213> Homo sapiens

<400> 13
Met Gly Leu Leu Leu Leu Val Leu Ile Leu Thr Pro Ser Leu Ala Ala 
1               5                   10                  15      


Tyr Arg His Pro Asp Phe Pro Leu Leu Glu Lys Ala Gln Gln Leu Leu 
            20                  25                  30          


Gln Ser Thr Gly Ser Pro Tyr Ser Thr Asn Cys Trp Leu Cys Thr Ser 
        35                  40                  45              


Ser Ser Thr Glu Thr Pro Gly Thr Ala Tyr Pro Ala Ser Pro Arg Glu 
    50                  55                  60                  


Trp Thr Ser Ile Glu Ala Glu Leu His Ile Ser Tyr Arg Trp Asp Pro 
65                  70                  75                  80  


Asn Leu Lys Gly Leu Met Arg Pro Ala Asn Ser Leu Leu Ser Thr Val 
                85                  90                  95      


Lys Gln Asp Phe Pro Asp Ile Arg Gln Lys Pro Pro Ile Phe Gly Pro 
            100                 105                 110         


Ile Phe Thr Asn Ile Asn Leu Met Gly Ile Ala Pro Ile Cys Val Met 
        115                 120                 125             


Ala Lys Arg Lys Asn Gly Thr Asn Val Gly Thr Leu Pro Ser Thr Val 
    130                 135                 140                 


Cys Asn Val Thr Phe Thr Val Asp Ser Asn Gln Gln Thr Tyr Gln Thr 
145                 150                 155                 160 


Tyr Thr His Asn Gln Phe Arg His Gln Pro Arg Phe Pro Lys Pro Pro 
                165                 170                 175     


Asn Ile Thr Phe Pro Gln Gly Thr Leu Leu Asp Lys Ser Ser Arg Phe 
            180                 185                 190         


Cys Gln Gly Arg Pro Ser Ser Cys Ser Thr Arg Asn Phe Trp Phe Arg 
        195                 200                 205             


Pro Ala Asp Tyr Asn Gln Cys Leu Gln Ile Ser Asn Leu Ser Ser Thr 
    210                 215                 220                 


Ala Glu Trp Val Leu Leu Asp Gln Thr Arg Asn Ser Leu Phe Trp Glu 
225                 230                 235                 240 


Asn Lys Thr Lys Gly Ala Asn Gln Ser Gln Thr Pro Cys Val Gln Val 
                245                 250                 255     


Leu Ala Gly Met Thr Ile Ala Thr Ser Tyr Leu Gly Ile Ser Ala Val 
            260                 265                 270         


Ser Glu Phe Phe Gly Thr Ser Leu Thr Pro Leu Phe His Phe His Ile 
        275                 280                 285             


Ser Thr Cys Leu Lys Thr Gln Gly Ala Phe Tyr Ile Cys Gly Gln Ser 
    290                 295                 300                 


Ile His Gln Cys Leu Pro Ser Asn Trp Thr Gly Thr Cys Thr Ile Gly 
305                 310                 315                 320 


Tyr Val Thr Pro Asp Ile Phe Ile Ala Pro Gly Asn Leu Ser Leu Pro 
                325                 330                 335     


Ile Pro Ile Tyr Gly Asn Ser Pro Leu Pro Arg Val Arg Arg Ala Ile 
            340                 345                 350         


His Phe Ile Pro Leu Leu Ala Gly Leu Gly Ile Leu Ala Gly Thr Gly 
        355                 360                 365             


Thr Gly Ile Ala Gly Ile Thr Lys Ala Ser Leu Thr Tyr Ser Gln Leu 
    370                 375                 380                 


Ser Lys Glu Ile Ala Asn Asn Ile Asp Thr Met Ala Lys Ala Leu Thr 
385                 390                 395                 400 


Thr Met Gln Glu Gln Ile Asp Ser Leu Ala Ala Val Val Leu Gln Asn 
                405                 410                 415     


Arg Arg Gly Leu Asp Met Leu Thr Ala Ala Gln Gly Gly Ile Cys Leu 
            420                 425                 430         


Ala Leu Asp Glu Lys Cys Cys Phe Trp Val Asn Gln Ser Gly Lys Val 
        435                 440                 445             


Gln Asp Asn Ile Arg Gln Leu Leu Asn Gln Ala Ser Ser Leu Arg Glu 
    450                 455                 460                 


Arg Ala Thr Gln Gly Trp Leu Asn Trp Glu Gly Thr Trp Lys Trp Phe 
465                 470                 475                 480 


Ser Trp Val Leu Pro Leu Thr Gly Pro Leu Val Ser Leu Leu Leu Leu 
                485                 490                 495     


Leu Leu Phe Gly Pro Cys Leu Leu Asn Leu Ile Thr Gln Phe Val Ser 
            500                 505                 510         


Ser Arg Leu Gln Ala Ile Lys Leu Gln Thr Asn Leu Ser Ala Gly Arg 
        515                 520                 525             


His Pro Arg Asn Ile Gln Glu Ser Pro Phe 
    530                 535             


<210> 14
<211> 604
<212> PRT
<213> Homo sapiens

<400> 14
Met Leu Gly Met Asn Met Leu Leu Ile Thr Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Leu Ser Met Leu Lys Gly Glu Pro Trp Glu Gly Cys Leu His Cys Thr 
            20                  25                  30          


His Thr Thr Trp Ser Gly Asn Ile Met Thr Lys Thr Leu Leu Tyr His 
        35                  40                  45              


Thr Tyr Tyr Glu Cys Ala Gly Thr Cys Leu Gly Thr Cys Thr His Asn 
    50                  55                  60                  


Gln Thr Thr Tyr Ser Val Cys Asp Pro Gly Arg Gly Gln Pro Tyr Val 
65                  70                  75                  80  


Cys Tyr Asp Pro Lys Ser Ser Pro Gly Thr Trp Phe Glu Ile His Val 
                85                  90                  95      


Gly Ser Lys Glu Gly Asp Leu Leu Asn Gln Thr Lys Val Phe Pro Ser 
            100                 105                 110         


Gly Lys Asp Val Val Ser Leu Tyr Phe Asp Val Cys Gln Ile Val Ser 
        115                 120                 125             


Met Gly Ser Leu Phe Pro Val Ile Phe Ser Ser Met Glu Tyr Tyr Ser 
    130                 135                 140                 


Ser Cys His Lys Asn Arg Tyr Ala His Pro Ala Cys Ser Thr Asp Ser 
145                 150                 155                 160 


Pro Val Thr Thr Cys Trp Asp Cys Thr Thr Trp Ser Thr Asn Gln Gln 
                165                 170                 175     


Ser Leu Gly Pro Ile Met Leu Thr Lys Ile Pro Leu Glu Pro Asp Cys 
            180                 185                 190         


Lys Thr Ser Thr Cys Asn Ser Val Asn Leu Thr Ile Leu Glu Pro Asp 
        195                 200                 205             


Gln Pro Ile Trp Thr Thr Gly Leu Lys Ala Pro Leu Gly Ala Arg Val 
    210                 215                 220                 


Ser Gly Glu Glu Ile Gly Pro Gly Ala Tyr Val Tyr Leu Tyr Ile Ile 
225                 230                 235                 240 


Lys Lys Thr Arg Thr Arg Ser Thr Gln Gln Phe Arg Val Phe Glu Ser 
                245                 250                 255     


Phe Tyr Glu His Val Asn Gln Lys Leu Pro Glu Pro Pro Pro Leu Ala 
            260                 265                 270         


Ser Asn Leu Phe Ala Gln Leu Ala Glu Asn Ile Ala Ser Ser Leu His 
        275                 280                 285             


Val Ala Ser Cys Tyr Val Cys Gly Gly Met Asn Met Gly Asp Gln Trp 
    290                 295                 300                 


Pro Trp Glu Ala Arg Glu Leu Met Pro Gln Asp Asn Phe Thr Leu Thr 
305                 310                 315                 320 


Ala Ser Ser Leu Glu Pro Ala Pro Ser Ser Gln Ser Ile Trp Phe Leu 
                325                 330                 335     


Lys Thr Ser Ile Ile Gly Lys Phe Cys Ile Ala Arg Trp Gly Lys Ala 
            340                 345                 350         


Phe Thr Asp Pro Val Gly Glu Leu Thr Cys Leu Gly Gln Gln Tyr Tyr 
        355                 360                 365             


Asn Glu Thr Leu Gly Lys Thr Leu Trp Arg Gly Lys Ser Asn Asn Ser 
    370                 375                 380                 


Glu Ser Pro His Pro Ser Pro Phe Ser Arg Phe Pro Ser Leu Asn His 
385                 390                 395                 400 


Ser Trp Tyr Gln Leu Glu Ala Pro Asn Thr Trp Gln Ala Pro Ser Gly 
                405                 410                 415     


Leu Tyr Trp Ile Cys Gly Pro Gln Ala Tyr Arg Gln Leu Pro Ala Lys 
            420                 425                 430         


Trp Ser Gly Ala Cys Val Leu Gly Thr Ile Arg Pro Ser Phe Phe Leu 
        435                 440                 445             


Met Pro Leu Lys Gln Gly Glu Ala Leu Gly Tyr Pro Ile Tyr Asp Glu 
    450                 455                 460                 


Thr Lys Arg Lys Ser Lys Arg Gly Ile Thr Ile Gly Asp Trp Lys Asp 
465                 470                 475                 480 


Asn Glu Trp Pro Pro Glu Arg Ile Ile Gln Tyr Tyr Gly Pro Ala Thr 
                485                 490                 495     


Trp Ala Glu Asp Gly Met Trp Gly Tyr Arg Thr Pro Val Tyr Met Leu 
            500                 505                 510         


Asn Arg Ile Ile Arg Leu Gln Ala Val Leu Glu Ile Ile Thr Asn Glu 
        515                 520                 525             


Thr Ala Gly Ala Leu Asn Leu Leu Ala Gln Gln Ala Thr Lys Met Arg 
    530                 535                 540                 


Asn Val Ile Tyr Gln Asn Arg Leu Ala Leu Asp Tyr Leu Leu Ala Gln 
545                 550                 555                 560 


Glu Glu Gly Val Cys Gly Lys Phe Asn Leu Thr Asn Cys Cys Leu Glu 
                565                 570                 575     


Leu Asp Asp Glu Gly Lys Val Ile Lys Glu Ile Thr Ala Lys Ile Gln 
            580                 585                 590         


Lys Leu Ala His Ile Pro Val Gln Thr Trp Lys Gly 
        595                 600                 


<210> 15
<211> 514
<212> PRT
<213> Homo sapiens

<400> 15
Met Asp Pro Leu His Thr Ile Glu Lys Val Pro Ala Arg Arg Asn Ile 
1               5                   10                  15      


His Asp Arg Gly His Gln Gly His Arg Met Gly Asp Gly Thr Pro Gly 
            20                  25                  30          


Arg Pro Lys Ile Ser Val Gln Gln Met Thr Arg Phe Ser Leu Ile Ile 
        35                  40                  45              


Phe Phe Leu Ser Ala Pro Phe Val Val Asn Ala Ser Thr Ser Asn Val 
    50                  55                  60                  


Phe Leu Gln Trp Ala His Ser Tyr Ala Asp Gly Leu Gln Gln Gly Asp 
65                  70                  75                  80  


Pro Cys Trp Val Cys Gly Ser Leu Pro Val Thr Asn Thr Met Glu Leu 
                85                  90                  95      


Pro Trp Trp Val Ser Pro Leu Gln Gly Lys Asp Trp Val Phe Phe Gln 
            100                 105                 110         


Ser Phe Ile Gly Asp Leu Lys Gln Trp Thr Gly Ala Gln Met Thr Gly 
        115                 120                 125             


Val Thr Arg Lys Asn Ile Ser Glu Trp Pro Ile Asn Lys Thr Leu Asn 
    130                 135                 140                 


Glu Pro Gly His Asp Lys Pro Phe Ser Val Asn Glu Thr Arg Asp Lys 
145                 150                 155                 160 


Val Ile Ala Phe Ala Ile Pro Leu Leu Asp Thr Lys Val Phe Val Gln 
                165                 170                 175     


Thr Ser Arg Pro Gln Asn Thr Gln Tyr Arg Asn Gly Phe Leu Gln Ile 
            180                 185                 190         


Trp Asp Gly Phe Ile Trp Leu Thr Ala Thr Lys Gly His Leu Ser Gln 
        195                 200                 205             


Ile Ala Pro Leu Cys Trp Glu Gln Arg Asn His Ser Leu Asp Asn Trp 
    210                 215                 220                 


Pro Asn Thr Thr Arg Val Met Gly Trp Ile Pro Pro Gly Gln Cys Arg 
225                 230                 235                 240 


His Thr Ile Leu Leu Gln Gln Arg Asp Leu Phe Ala Thr Asp Trp Ser 
                245                 250                 255     


Gln Gln Pro Gly Leu Asn Trp Tyr Ala Pro Asn Gly Thr Gln Trp Leu 
            260                 265                 270         


Cys Ser Pro Asn Leu Trp Pro Trp Leu Pro Ser Gly Trp Leu Gly Cys 
        275                 280                 285             


Cys Thr Leu Gly Ile Pro Trp Ala Gln Gly Arg Trp Val Lys Thr Met 
    290                 295                 300                 


Glu Val Tyr Pro Tyr Leu Pro His Val Val Asn Gln Gly Thr Arg Ala 
305                 310                 315                 320 


Ile Val His Arg Asn Asp His Leu Pro Thr Ile Phe Met Pro Ser Val 
                325                 330                 335     


Gly Leu Gly Thr Val Ile Gln His Ile Glu Ala Leu Ala Asn Phe Thr 
            340                 345                 350         


Gln Arg Ala Leu Asn Asp Ser Leu Gln Ser Ile Ser Leu Met Asn Ala 
        355                 360                 365             


Glu Val Tyr Tyr Met His Glu Asp Ile Leu Gln Asn Arg Met Ala Leu 
    370                 375                 380                 


Asp Ile Leu Thr Ala Ala Glu Gly Gly Thr Cys Ala Leu Ile Lys Thr 
385                 390                 395                 400 


Glu Cys Cys Val Tyr Ile Pro Asn Asn Ser Arg Asn Ile Ser Leu Ala 
                405                 410                 415     


Leu Glu Asp Thr Cys Arg Gln Ile Gln Val Ile Ser Ser Ser Ala Leu 
            420                 425                 430         


Ser Leu His Asp Trp Ile Ala Ser Gln Phe Ser Gly Arg Pro Ser Trp 
        435                 440                 445             


Trp Gln Lys Ile Leu Ile Val Leu Ala Thr Leu Trp Ser Val Gly Ile 
    450                 455                 460                 


Ala Leu Cys Cys Gly Leu Tyr Phe Cys Arg Met Phe Ser Gln His Ile 
465                 470                 475                 480 


Pro Gln Thr His Ser Ile Ile Phe Gln Gln Glu Leu Pro Leu Ser Pro 
                485                 490                 495     


Pro Ser Gln Glu His Tyr Gln Ser Gln Arg Asp Ile Phe His Ser Asn 
            500                 505                 510         


Ala Pro 
        


<210> 16
<211> 527
<212> PRT
<213> Homo sapiens

<400> 16
Met Asn Ser Pro Cys Asp Arg Leu Gln Gln Phe Ile Gln Val Leu Leu 
1               5                   10                  15      


Glu Glu Ser Trp Ser Phe Pro Ser Phe Ala Asn Thr Leu His Trp Pro 
            20                  25                  30          


Glu Asn Leu Leu Ser Tyr Ile Asp Glu Leu Val Trp Gln Gly Ser Leu 
        35                  40                  45              


Gln Asn Phe His Gln His Glu Val Arg Phe Asp Lys Pro Pro Leu Arg 
    50                  55                  60                  


Leu Pro Leu Thr Gly Phe Ser Ser Leu Thr Glu Asn Trp Ser Ser Arg 
65                  70                  75                  80  


Gln Ala Val Ser Ser Arg Leu Val Ala Thr Ala Ala Ser Pro Pro Ala 
                85                  90                  95      


Gly Cys Gln Ala Pro Ile Ala Phe Leu Gly Leu Lys Phe Ser Ser Leu 
            100                 105                 110         


Gly Pro Ala Arg Lys Asn Pro Ala Leu Cys Phe Leu Tyr Asp Gln Ser 
        115                 120                 125             


Asn Ser Lys Cys Asn Thr Ser Trp Val Lys Glu Asn Val Gly Cys Pro 
    130                 135                 140                 


Trp His Trp Cys Asn Ile His Glu Ala Leu Ile Arg Thr Glu Lys Gly 
145                 150                 155                 160 


Ser Asp Pro Met Phe Tyr Val Asn Thr Ser Thr Gly Gly Arg Asp Gly 
                165                 170                 175     


Phe Asn Gly Phe Asn Leu Gln Ile Ser Asp Pro Trp Asp Pro Arg Trp 
            180                 185                 190         


Ala Ser Gly Val Asp Gly Gly Leu Tyr Glu His Lys Thr Phe Met Tyr 
        195                 200                 205             


Pro Val Ala Lys Ile Arg Ile Ala Arg Thr Leu Lys Thr Thr Val Thr 
    210                 215                 220                 


Gly Leu Ser Asp Leu Ala Ser Ser Ile Gln Ser Ala Glu Lys Glu Leu 
225                 230                 235                 240 


Thr Ser Gln Leu Gln Pro Ala Ala Asp Gln Ala Lys Ser Ser Arg Phe 
                245                 250                 255     


Ser Trp Leu Thr Leu Ile Ser Glu Gly Ala Gln Leu Leu Gln Ser Thr 
            260                 265                 270         


Gly Val Gln Asn Leu Ser His Cys Phe Leu Cys Ala Ala Leu Arg Arg 
        275                 280                 285             


Pro Pro Leu Val Ala Val Pro Leu Pro Thr Pro Phe Asn Tyr Thr Ile 
    290                 295                 300                 


Asn Ser Ser Thr Pro Ile Pro Pro Val Pro Lys Gly Gln Val Pro Leu 
305                 310                 315                 320 


Phe Ser Asp Pro Ile Arg His Lys Phe Pro Phe Cys Tyr Ser Thr Pro 
                325                 330                 335     


Asn Ala Ser Trp Cys Asn Gln Thr Arg Met Leu Thr Ser Thr Pro Ala 
            340                 345                 350         


Pro Pro Arg Gly Tyr Phe Trp Cys Asn Ser Thr Leu Thr Lys Val Leu 
        355                 360                 365             


Asn Ser Thr Gly Asn His Thr Leu Cys Leu Pro Ile Ser Leu Ile Pro 
    370                 375                 380                 


Gly Leu Thr Leu Tyr Ser Gln Asp Glu Leu Ser His Leu Leu Ala Trp 
385                 390                 395                 400 


Thr Glu Pro Arg Pro Gln Asn Lys Ser Lys Trp Ala Ile Phe Leu Pro 
                405                 410                 415     


Leu Val Leu Gly Ile Ser Leu Ala Ser Ser Leu Val Ala Ser Gly Leu 
            420                 425                 430         


Gly Lys Gly Ala Leu Thr His Ser Ile Gln Thr Ser Gln Asp Leu Ser 
        435                 440                 445             


Thr His Leu Gln Leu Ala Ile Glu Ala Ser Ala Glu Ser Leu Asp Ser 
    450                 455                 460                 


Leu Gln Arg Gln Ile Thr Thr Val Ala Gln Val Ala Ala Gln Asn Arg 
465                 470                 475                 480 


Gln Ala Leu Asp Leu Leu Met Ala Glu Lys Gly Arg Thr Cys Leu Phe 
                485                 490                 495     


Leu Gln Glu Glu Cys Cys Tyr Tyr Leu Asn Glu Ser Gly Val Val Glu 
            500                 505                 510         


Asn Ser Leu Gln Thr Leu Lys Lys Lys Lys Ser Ser Lys Arg Ser 
        515                 520                 525         


<210> 17
<211> 584
<212> PRT
<213> Homo sapiens

<400> 17
Met Ala Arg Pro Ser Pro Leu Cys Leu Leu Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Thr Pro Ile Val Pro Ser Asn Ser Leu Leu Thr Glu Pro Pro Phe Arg 
            20                  25                  30          


Trp Arg Phe Tyr Leu His Glu Thr Trp Thr Gln Gly Asn Arg Leu Ser 
        35                  40                  45              


Thr Val Thr Leu Ala Thr Val Asp Cys Gln Pro His Gly Cys Gln Ala 
    50                  55                  60                  


Gln Val Thr Phe Asn Phe Thr Ser Phe Lys Ser Val Leu Arg Gly Trp 
65                  70                  75                  80  


Ser Asn Pro Thr Ile Cys Phe Val Tyr Asp Gln Thr His Ser Asn Cys 
                85                  90                  95      


Arg Asp Tyr Trp Val Asp Thr Asn Gly Gly Cys Pro Tyr Ala Tyr Cys 
            100                 105                 110         


Arg Met His Val Thr Gln Leu His Thr Ala Lys Lys Leu Gln His Thr 
        115                 120                 125             


Tyr Arg Leu Thr Ser Asp Gly Arg Thr Thr Tyr Phe Leu Thr Ile Pro 
    130                 135                 140                 


Asp Pro Trp Asp Ser Arg Trp Val Ser Gly Val Thr Gly Arg Leu Tyr 
145                 150                 155                 160 


Arg Trp Pro Thr Asp Ser Tyr Pro Val Gly Lys Leu Arg Ile Phe Leu 
                165                 170                 175     


Thr Tyr Ile Arg Val Ile Pro Gln Val Leu Ser Asn Leu Lys Asp Gln 
            180                 185                 190         


Ala Asp Asn Ile Lys His Gln Glu Glu Val Ile Asn Thr Leu Val Gln 
        195                 200                 205             


Ser His Pro Lys Ala Asp Met Val Thr Tyr Asp Asp Lys Ala Glu Ala 
    210                 215                 220                 


Gly Pro Phe Ser Trp Ile Thr Leu Val Arg His Gly Ala Arg Leu Val 
225                 230                 235                 240 


Asn Met Ala Gly Leu Val Asn Leu Ser His Cys Phe Leu Cys Thr Ala 
                245                 250                 255     


Leu Ser Gln Pro Pro Leu Val Ala Val Pro Leu Pro Gln Ala Phe Asn 
            260                 265                 270         


Thr Ser Gly Asn His Thr Ala His Pro Ser Gly Val Phe Ser Glu Gln 
        275                 280                 285             


Val Pro Leu Phe Arg Asp Pro Leu Gln Pro Gln Phe Pro Phe Cys Tyr 
    290                 295                 300                 


Thr Thr Pro Asn Ser Ser Trp Cys Asn Gln Thr Tyr Ser Gly Ser Leu 
305                 310                 315                 320 


Ser Asn Leu Ser Ala Pro Ala Gly Gly Tyr Phe Trp Cys Asn Phe Thr 
                325                 330                 335     


Leu Thr Lys His Leu Asn Ile Ser Ser Asn Asn Thr Leu Ser Arg Asn 
            340                 345                 350         


Leu Cys Leu Pro Ile Ser Leu Val Pro Arg Leu Thr Leu Tyr Ser Glu 
        355                 360                 365             


Ala Glu Leu Ser Ser Leu Val Asn Pro Pro Met Arg Gln Lys Arg Ala 
    370                 375                 380                 


Val Phe Pro Pro Leu Val Ile Gly Val Ser Leu Thr Ser Ser Leu Val 
385                 390                 395                 400 


Ala Ser Gly Leu Gly Thr Gly Ala Ile Val His Phe Ile Ser Ser Ser 
                405                 410                 415     


Gln Asp Leu Ser Ile Lys Leu Gln Met Ala Ile Glu Ala Ser Ala Glu 
            420                 425                 430         


Ser Leu Ala Ser Leu Gln Arg Gln Ile Thr Ser Val Ala Lys Val Ala 
        435                 440                 445             


Met Gln Asn Arg Arg Ala Leu Asp Leu Leu Thr Ala Asp Lys Gly Gly 
    450                 455                 460                 


Thr Cys Met Phe Leu Gly Glu Glu Cys Cys Tyr Tyr Ile Asn Glu Ser 
465                 470                 475                 480 


Gly Leu Val Glu Thr Ser Leu Leu Thr Leu Asp Lys Ile Arg Asp Gly 
                485                 490                 495     


Leu His Arg Pro Ser Ser Thr Pro Asn Tyr Gly Gly Gly Trp Trp Gln 
            500                 505                 510         


Ser Pro Leu Thr Thr Trp Ile Ile Pro Phe Ile Ser Pro Ile Leu Ile 
        515                 520                 525             


Ile Cys Leu Leu Leu Leu Ile Ala Pro Cys Val Leu Lys Phe Ile Lys 
    530                 535                 540                 


Asn Arg Ile Ser Glu Val Ser Arg Val Thr Val Asn Gln Met Leu Leu 
545                 550                 555                 560 


His Pro Tyr Ser Arg Leu Pro Thr Ser Glu Asp His Tyr Asp Asp Ala 
                565                 570                 575     


Leu Thr Gln Gln Glu Ala Ala Arg 
            580                 


<210> 18
<211> 699
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 


Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Val Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             


Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 


Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 


Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     


Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         


Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             


Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 


His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 


Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     


Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         


Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             


Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 


Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 


Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     


Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         


Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             


Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 


<210> 19
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      


Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          


Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              


Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  


Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  


Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      


Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         


Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             


Gly Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 


Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 


Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     


Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         


Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             


Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 


Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 


Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     


Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         


Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             


Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 


Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 


Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     


Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         


Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             


Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 


Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 


Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     


Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         


Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             


Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 


Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 


Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     


Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         


Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             


Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 


Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 


Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     


Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         


Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             


Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 


Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 


Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     


Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     


<210> 20
<211> 1710
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1700                 1705                 1710 


<210> 21
<211> 1419
<212> PRT
<213> Streptococcus pyogenes

<400> 21
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Ser  Gly Gly Gly Gly Ser  Gly Lys Arg Thr Ala  Asp Gly Ser 
    1370                 1375                 1380             


Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val Ser Ser  Gly Gly Asp 
    1385                 1390                 1395             


Tyr Lys  Asp His Asp Gly Asp  Tyr Lys Asp His Asp  Ile Asp Tyr 
    1400                 1405                 1410             


Lys Asp  Asp Asp Asp Lys 
    1415                 


<210> 22
<211> 1053
<212> PRT
<213> Staphylococcus aureus

<400> 22
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 23
<211> 1307
<212> PRT
<213> Acidaminococcus sp.

<400> 23
Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210> 24
<211> 175
<212> PRT
<213> Homo sapiens

<400> 24
Met Asp Ser Gly Arg Asp Phe Leu Thr Leu His Gly Leu Gln Asp Asp 
1               5                   10                  15      


Glu Asp Leu Gln Ala Leu Leu Lys Gly Ser Gln Leu Leu Lys Val Lys 
            20                  25                  30          


Ser Ser Ser Trp Arg Arg Glu Arg Phe Tyr Lys Leu Gln Glu Asp Cys 
        35                  40                  45              


Lys Thr Ile Trp Gln Glu Ser Arg Lys Val Met Arg Thr Pro Glu Ser 
    50                  55                  60                  


Gln Leu Phe Ser Ile Glu Asp Ile Gln Glu Val Arg Met Gly His Arg 
65                  70                  75                  80  


Thr Glu Gly Leu Glu Lys Phe Ala Arg Asp Val Pro Glu Asp Arg Cys 
                85                  90                  95      


Phe Ser Ile Val Phe Lys Asp Gln Arg Asn Thr Leu Asp Leu Ile Ala 
            100                 105                 110         


Pro Ser Pro Ala Asp Ala Gln His Trp Val Leu Gly Leu His Lys Ile 
        115                 120                 125             


Ile His His Ser Gly Ser Met Asp Gln Arg Gln Lys Leu Gln His Trp 
    130                 135                 140                 


Ile His Ser Cys Leu Arg Lys Ala Asp Lys Asn Lys Asp Asn Lys Met 
145                 150                 155                 160 


Ser Phe Lys Glu Leu Gln Asn Phe Leu Lys Glu Leu Asn Ile Gln 
                165                 170                 175 


<210> 25
<211> 168
<212> PRT
<213> Homo sapiens

<400> 25
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Asp Pro Pro Val 
                165             


<210> 26
<211> 92
<212> PRT
<213> Homo sapiens

<400> 26
Lys Met Gly Pro Val Asp Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg 
1               5                   10                  15      


Gln Leu Leu Leu Thr Glu Gly Pro His Leu Tyr Tyr Val Asp Pro Val 
            20                  25                  30          


Asn Lys Val Leu Lys Gly Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro 
        35                  40                  45              


Glu Ala Lys Asn Phe Lys Thr Phe Phe Val His Thr Pro Asn Arg Thr 
    50                  55                  60                  


Tyr Tyr Leu Met Asp Pro Ser Gly Asn Ala His Lys Trp Cys Arg Lys 
65                  70                  75                  80  


Ile Gln Glu Val Trp Arg Gln Arg Tyr Gln Ser His 
                85                  90          


<210> 27
<211> 229
<212> PRT
<213> Homo sapiens

<400> 27
Met Ser Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe 
1               5                   10                  15      


Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile 
            20                  25                  30          


Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln 
        35                  40                  45              


Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu 
    50                  55                  60                  


Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys 
65                  70                  75                  80  


Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe 
                85                  90                  95      


Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr 
            100                 105                 110         


Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp 
        115                 120                 125             


Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu 
    130                 135                 140                 


Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val 
145                 150                 155                 160 


Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr 
                165                 170                 175     


Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn 
            180                 185                 190         


Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met 
        195                 200                 205             


Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg 
    210                 215                 220                 


Asn Arg Glu Met Val 
225                 


<210> 28
<211> 238
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210> 29
<211> 236
<212> PRT
<213> Homo sapiens

<400> 29
Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210> 30
<211> 10
<212> PRT
<213> Homo sapiens

<400> 30
Glu Val Thr Glu Leu Thr Arg Glu Gly Glu 
1               5                   10  


<210> 31
<211> 21
<212> PRT
<213> Homo sapiens

<400> 31
Gly Asn Tyr Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr 
1               5                   10                  15      


Ile Ile Glu Leu Lys 
            20      


<210> 32
<211> 293
<212> PRT
<213> Homo sapiens

<400> 32
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Glu 
    290             


<210> 33
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Phe Lys Cys Glu His Cys Arg Ile Leu Phe Leu Asp His Val Met Phe 
1               5                   10                  15      


Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe Lys Cys Asn 
            20                  25                  30          


Met Cys Gly Glu Lys Cys Asp Gly Pro Val Gly Leu Phe Val His Met 
        35                  40                  45              


Ala Arg Asn Ala His Gly Glu Lys Pro Phe Tyr Cys Glu His Cys Glu 
    50                  55                  60                  


Ile Thr Phe Arg Asp Val Val Met Tyr Ser Leu His Lys Gly Tyr His 
65                  70                  75                  80  


Gly Phe Arg Asp Pro Phe Glu Cys Asn Ile Cys Gly Tyr His Ser Gln 
                85                  90                  95      


Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu His 
            100                 105                 110 


<210> 34
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
His His Cys Gln His Cys Asp Met Tyr Phe Ala Asp Asn Ile Leu Tyr 
1               5                   10                  15      


Thr Ile His Met Gly Cys His Ser Cys Asp Asp Val Phe Lys Cys Asn 
            20                  25                  30          


Met Cys Gly Glu Lys Cys Asp Gly Pro Val Gly Leu Phe Val His Met 
        35                  40                  45              


Ala Arg Asn Ala His Gly Glu Lys Pro Thr Lys Cys Val His Cys Gly 
    50                  55                  60                  


Ile Val Phe Leu Asp Glu Val Met Tyr Ala Leu His Met Ser Cys His 
65                  70                  75                  80  


Gly Phe Arg Asp Pro Phe Glu Cys Asn Ile Cys Gly Tyr His Ser Gln 
                85                  90                  95      


Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu His 
            100                 105                 110 


<210> 35
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Gly Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105                 110 


<210> 36
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Ala Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
1               5                   10                  15      


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
            20                  25                  30          


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
        35                  40                  45              


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
    50                  55                  60                  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
65                  70                  75                  80  


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
                85                  90                  95      


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105                 110     


<210> 37
<211> 97
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Gly Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys 
    


<210> 38
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210> 39
<211> 93
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Gln Gly Met Leu Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90              


<210> 40
<211> 277
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala 
            20                  25                  30          


Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys 
        35                  40                  45              


Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu 
                85                  90                  95      


Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly 
145                 150                 155                 160 


Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp 
            180                 185                 190         


Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr 
    210                 215                 220                 


Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser 
        275         


<210> 41
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
            20                  25                  30          


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
        35                  40                  45              


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
    50                  55                  60                  


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
65                  70                  75                  80  


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
                85                  90                  95      


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
            100                 105                 110         


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
        115                 120                 125             


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
    130                 135                 140                 


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
145                 150                 155                 160 


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
                165                 170                 175     


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
            180                 185                 190         


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
        195                 200                 205             


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
    210                 215                 220                 


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser 
225                 230                 235         


<210> 42
<211> 573
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
            20                  25                  30          


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
        35                  40                  45              


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
    50                  55                  60                  


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
65                  70                  75                  80  


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
                85                  90                  95      


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
            100                 105                 110         


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
        115                 120                 125             


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
    130                 135                 140                 


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
145                 150                 155                 160 


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
                165                 170                 175     


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
            180                 185                 190         


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
        195                 200                 205             


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
    210                 215                 220                 


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
225                 230                 235                 240 


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
                245                 250                 255     


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
            260                 265                 270         


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
        275                 280                 285             


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
    290                 295                 300                 


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
305                 310                 315                 320 


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
                325                 330                 335     


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
            340                 345                 350         


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
        355                 360                 365             


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
    370                 375                 380                 


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
385                 390                 395                 400 


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
                405                 410                 415     


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
            420                 425                 430         


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
        435                 440                 445             


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
    450                 455                 460                 


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
                485                 490                 495     


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
            500                 505                 510         


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
        515                 520                 525             


Glu Glu Leu Leu Ser Lys Asp Tyr His Leu Glu Asn Glu Val Ala Arg 
    530                 535                 540                 


Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
545                 550                 555                 560 


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser 
                565                 570             


<210> 43
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Arg Tyr Ser 
            20                  25                  30          


Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala 
        35                  40                  45              


Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Ser Asn 
                85                  90                  95      


Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 44
<211> 102
<212> PRT
<213> Nostoc punctiforme

<400> 44
Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210> 45
<211> 39
<212> PRT
<213> Nostoc punctiforme

<400> 45
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      


Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          


Ile Ala Ser Asn Cys Phe Asn 
        35                  


<210> 46
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210> 47
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      


Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          


Val Ala Ser Asn 
        35      


<210> 48
<211> 184
<212> PRT
<213> Saccharomyces cerevisiae

<400> 48
Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu 
1               5                   10                  15      


Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly 
            20                  25                  30          


Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr 
        35                  40                  45              


Ser Val Val Gln Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser 
    50                  55                  60                  


Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu 
65                  70                  75                  80  


Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile 
                85                  90                  95      


Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys 
            100                 105                 110         


Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys 
        115                 120                 125             


Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu 
    130                 135                 140                 


Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu 
145                 150                 155                 160 


Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr 
                165                 170                 175     


Gln Thr Tyr Ala Pro Ile Leu Tyr 
            180                 


<210> 49
<211> 65
<212> PRT
<213> Saccharomyces cerevisiae

<400> 49
Val Leu Leu Asn Val Leu Ser Lys Cys Ala Gly Ser Lys Lys Phe Arg 
1               5                   10                  15      


Pro Ala Pro Ala Ala Ala Phe Ala Arg Glu Cys Arg Gly Phe Tyr Phe 
            20                  25                  30          


Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr Leu Ser 
        35                  40                  45              


Asp Asp Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val Val His 
    50                  55                  60                  


Asn 
65  


<210> 50
<211> 123
<212> PRT
<213> Synechocystis sp.

<400> 50
Cys Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser 
            20                  25                  30          


Val Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser 
    50                  55                  60                  


Val Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln 
65                  70                  75                  80  


Leu Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr 
                85                  90                  95      


Leu Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu 
            100                 105                 110         


Pro Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 
        115                 120             


<210> 51
<211> 36
<212> PRT
<213> Synechocystis sp.

<400> 51
Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn 
        35      


<210> 52
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Val Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
1               5                   10                  


<210> 53
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Val Thr Thr Leu Ser Gly Leu Ser Gly Glu Gln Gly Pro Ser Gly 
1               5                   10                  15      


Asp Met Thr Thr Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            20                  25                  30          


Arg Asp Glu Asp Gly Arg Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        35                  40                  45              


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly His Val 
    50                  55                  60                  


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
65                  70                  75                  80  


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                85                  90                  95      


Glu Gln Gly Gln Val Thr Val Asn Gly Glu Ala Thr Lys Gly Asp Ala 
            100                 105                 110         


His Thr Gly Ser Ser Gly Ser 
        115                 


<210> 54
<211> 130
<212> PRT
<213> Enterobacteria phage MS2

<400> 54
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210> 55
<211> 130
<212> PRT
<213> Enterobacteria phage MS2

<400> 55
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210> 56
<211> 130
<212> PRT
<213> Enterobacteria phage MS2

<400> 56
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210> 57
<211> 121
<212> PRT
<213> Pseudomonas phage PP7

<400> 57
Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu Thr Glu 
1               5                   10                  15      


Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val Gly Pro 
            20                  25                  30          


Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn Gly Ala 
        35                  40                  45              


Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp Val Val 
    50                  55                  60                  


Asp Ser Gly Leu Pro Lys Val Arg Tyr Thr Gln Val Trp Ser His Asp 
65                  70                  75                  80  


Val Thr Ile Val Ala Asn Ser Thr Glu Ala Ser Arg Lys Ser Leu Tyr 
                85                  90                  95      


Asp Leu Thr Lys Ser Leu Val Ala Thr Ser Gln Val Glu Asp Leu Val 
            100                 105                 110         


Val Asn Leu Val Pro Leu Gly Arg Ser 
        115                 120     


<210> 58
<211> 62
<212> PRT
<213> Escherichia virus Mu

<400> 58
Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr 
    50                  55                  60          


<210> 59
<211> 179
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Ser Thr Arg Pro Gly Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg 
1               5                   10                  15      


Asn Phe Ser Ile Pro Asn His Leu Ala Arg His Thr Arg Thr His Thr 
            20                  25                  30          


Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln 
        35                  40                  45              


Ser Ala His Leu Lys Arg His Leu Arg Thr His Thr Gly Glu Lys Pro 
    50                  55                  60                  


Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Asp Val Ser Leu 
65                  70                  75                  80  


Val Arg His Leu Lys Thr His Leu Arg Gln Lys Asp Gly Glu Arg Pro 
                85                  90                  95      


Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Ser Ala Gln Ala Leu 
            100                 105                 110         


Ala Arg His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Gly Gly Asn Leu Thr Arg His Leu 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg 
145                 150                 155                 160 


Asn Phe Ser Gln His Pro Asn Leu Thr Arg His Leu Lys Thr His Leu 
                165                 170                 175     


Arg Gly Ser 
            


<210> 60
<211> 178
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Ser Arg Pro Gly Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
1               5                   10                  15      


Phe Ser Thr Met Ala Val Leu Arg Arg His Thr Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Arg 
        35                  40                  45              


Glu Val Leu Glu Asn His Leu Arg Thr His Thr Gly Glu Lys Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Thr Val Asn Leu Asp 
65                  70                  75                  80  


Arg His Leu Lys Thr His Leu Arg Gln Lys Asp Gly Glu Arg Pro Phe 
                85                  90                  95      


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Lys Lys Asp His Leu His 
            100                 105                 110         


Arg His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile 
        115                 120                 125             


Cys Met Arg Asn Phe Ser Gln Arg Pro His Leu Thr Asn His Leu Arg 
    130                 135                 140                 


Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
145                 150                 155                 160 


Phe Ser Val Gly Ala Ser Leu Lys Arg His Leu Lys Thr His Leu Arg 
                165                 170                 175     


Gly Ser 
        


<210> 61
<211> 90
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Ser Arg Pro Gly Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
1               5                   10                  15      


Phe Ser Asp Lys Thr Lys Leu Arg Val His Thr Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Val Arg 
        35                  40                  45              


His Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Thr Ser Leu Gln 
65                  70                  75                  80  


Arg His Leu Lys Thr His Leu Arg Gly Phe 
                85                  90  


<210> 62
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Ser Arg Pro Gly Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
1               5                   10                  15      


Phe Ser Arg Arg His Gly Leu Asp Arg His Thr Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Asp His 
        35                  40                  45              


Ser Ser Leu Lys Arg His Leu Arg Thr His Thr Gly Ser Gln Lys Pro 
    50                  55                  60                  


Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Val Arg His Asn Leu 
65                  70                  75                  80  


Thr Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg 
                85                  90                  95      


Ile Cys Met Arg Asn Phe Ser Asp His Ser Asn Leu Ser Arg His Leu 
            100                 105                 110         


Lys Thr His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met 
        115                 120                 125             


Arg Asn Phe Ser Gln Arg Ser Ser Leu Val Arg His Leu Arg Thr His 
    130                 135                 140                 


Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
145                 150                 155                 160 


Glu Ser Gly His Leu Lys Arg His Leu Arg Thr His Leu Arg Gly Ser 
                165                 170                 175     


<210> 63
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Ser Arg Pro Gly Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
1               5                   10                  15      


Phe Ser Thr Arg Gln Asn Leu Asp Thr His Thr Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Arg 
        35                  40                  45              


Asp Thr Leu Glu Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Pro Asp Ala Leu Pro 
65                  70                  75                  80  


Arg His Leu Lys Thr His Leu Arg Gly Ser Gln Leu Val Lys Ser Glu 
                85                  90                  95      


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
            100                 105                 110         


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
        115                 120                 125             


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
    130                 135                 140                 


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
145                 150                 155                 160 


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
                165                 170                 175     


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
            180                 185                 190         


Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
        195                 200                 205             


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
    210                 215                 220                 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
225                 230                 235                 240 


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
                245                 250                 255     


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
            260                 265                 270         


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
        275                 280                 285     


<210> 64
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Ser Arg Pro Gly Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
1               5                   10                  15      


Phe Ser Ser Pro Ser Lys Leu Ile Arg His Thr Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Asp Gly 
        35                  40                  45              


Ser Asn Leu Ala Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Val Asp Asn Leu Pro 
65                  70                  75                  80  


Arg His Leu Lys Thr His Leu Arg Gly Ser Gln Leu Val Lys Ser Glu 
                85                  90                  95      


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
            100                 105                 110         


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
        115                 120                 125             


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
    130                 135                 140                 


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
145                 150                 155                 160 


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
                165                 170                 175     


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
            180                 185                 190         


Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
        195                 200                 205             


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
    210                 215                 220                 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
225                 230                 235                 240 


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
                245                 250                 255     


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
            260                 265                 270         


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
        275                 280                 285     


<210> 65
<211> 196
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210> 66
<211> 199
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Val His Asp His Lys Leu Glu Leu Ala Lys Leu Ile Arg Asn Tyr Glu 
1               5                   10                  15      


Thr Asn Arg Lys Glu Cys Leu Asn Ser Arg Tyr Asn Glu Thr Leu Leu 
            20                  25                  30          


Arg Ser Asp Tyr Leu Asp Pro Phe Phe Glu Leu Leu Gly Trp Asp Ile 
        35                  40                  45              


Lys Asn Lys Ala Gly Lys Pro Thr Asn Glu Arg Glu Val Val Leu Glu 
    50                  55                  60                  


Glu Ala Leu Lys Ala Ser Ala Ser Glu His Ser Lys Lys Pro Asp Tyr 
65                  70                  75                  80  


Thr Phe Arg Leu Phe Ser Glu Arg Lys Phe Phe Leu Glu Ala Lys Lys 
                85                  90                  95      


Pro Ser Val His Ile Glu Ser Asp Asn Glu Thr Ala Lys Gln Val Arg 
            100                 105                 110         


Arg Tyr Gly Phe Thr Ala Lys Leu Lys Ile Ser Val Leu Ser Asn Phe 
        115                 120                 125             


Glu Tyr Leu Val Ile Tyr Asp Thr Ser Val Lys Val Asp Gly Asp Asp 
    130                 135                 140                 


Thr Phe Asn Lys Ala Arg Ile Lys Lys Tyr His Tyr Thr Glu Tyr Glu 
145                 150                 155                 160 


Thr His Phe Asp Glu Ile Cys Asp Leu Leu Gly Arg Glu Ser Val Tyr 
                165                 170                 175     


Ser Gly Asn Phe Asp Lys Glu Trp Leu Ser Ile Glu Asn Lys Ile Asn 
            180                 185                 190         


His Phe Ser Val Asp Thr Leu 
        195                 


<210> 67
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Tyr Asn Glu Thr Leu Leu Arg Ser Asp Tyr Leu Asp Pro Phe Phe Glu 
1               5                   10                  15      


Leu Leu Gly Trp Asp Ile Lys Asn Lys Ala Gly Lys Pro Thr Asn Glu 
            20                  25                  30          


Arg Glu Val Val Leu Glu Glu Ala Leu Lys Ala Ser Ala Ser Glu His 
        35                  40                  45              


Ser Lys Lys Pro Asp Tyr Thr Phe Arg Leu Phe Ser Glu Arg Lys Phe 
    50                  55                  60                  


Phe Leu Glu Ala Lys Lys Pro Ser Val His Ile Glu Ser Asp Asn Glu 
65                  70                  75                  80  


Thr Ala Lys Gln Val Arg Arg Tyr Gly Phe Thr Ala Lys Leu Lys Ile 
                85                  90                  95      


Ser Val Leu Ser Asn Phe Glu Tyr Leu Val Ile Tyr Asp Thr Ser Val 
            100                 105                 110         


Lys Val Asp Gly Asp Asp Thr 
        115                 


<210> 68
<211> 972
<212> PRT
<213> Ruminococcus flavefaciens

<400> 68
Glu Ala Ser Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val 
1               5                   10                  15      


Lys Ser Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala 
            20                  25                  30          


Glu Gly Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile 
        35                  40                  45              


Arg Ser Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys 
    50                  55                  60                  


Asn Ala Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly 
65                  70                  75                  80  


Tyr Ala Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln 
                85                  90                  95      


Asp Met Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu 
            100                 105                 110         


Ser Ala Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile 
        115                 120                 125             


Leu Asp Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr 
    130                 135                 140                 


Ala Val Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly 
145                 150                 155                 160 


Lys Phe Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His 
                165                 170                 175     


His Arg Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys 
            180                 185                 190         


Ala Gln Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly 
        195                 200                 205             


Tyr Phe Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile 
    210                 215                 220                 


Asn Tyr Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Arg His Trp Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg 
                245                 250                 255     


Thr Trp Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser 
            260                 265                 270         


Thr Leu Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser 
        275                 280                 285             


Phe Ser Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu 
    290                 295                 300                 


Gly Ile Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile 
305                 310                 315                 320 


Met Lys Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu 
                325                 330                 335     


Val Met Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys 
            340                 345                 350         


Val Phe Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val 
        355                 360                 365             


Ile Tyr Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn 
    370                 375                 380                 


Lys Ser Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe 
385                 390                 395                 400 


Val Ile Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu 
                405                 410                 415     


Tyr Tyr Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met 
            420                 425                 430         


His Asn Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys 
        435                 440                 445             


Lys Asp Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val 
    450                 455                 460                 


Ser Ala Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly 
465                 470                 475                 480 


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn 
                485                 490                 495     


Ile Gln Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys 
            500                 505                 510         


Phe Val Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp 
        515                 520                 525             


Glu Leu Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala 
    530                 535                 540                 


Asp Ala Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr 
545                 550                 555                 560 


Asn Leu Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu 
                565                 570                 575     


Asp Glu Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn 
            580                 585                 590         


Phe Ile Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile 
        595                 600                 605             


Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala 
    610                 615                 620                 


Val Val Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln 
625                 630                 635                 640 


Gly Gln Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile 
                645                 650                 655     


Gly Lys Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr 
            660                 665                 670         


Lys Ile Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser 
        675                 680                 685             


Val Ile Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys 
    690                 695                 700                 


Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn 
705                 710                 715                 720 


Ile Val Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu 
                725                 730                 735     


Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys 
            740                 745                 750         


Lys Leu Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly 
        755                 760                 765             


Ile Asp Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met 
    770                 775                 780                 


Ala Glu Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro 
785                 790                 795                 800 


Lys Leu Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu 
                805                 810                 815     


Glu Phe Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn 
            820                 825                 830         


Ala Tyr Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu 
        835                 840                 845             


Leu Arg Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val 
    850                 855                 860                 


His Leu Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala 
865                 870                 875                 880 


Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile 
                885                 890                 895     


Ile Met Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr 
            900                 905                 910         


Phe Asp Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys 
        915                 920                 925             


Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu 
    930                 935                 940                 


Ser Ile Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys 
945                 950                 955                 960 


Glu Lys Lys Lys Val Ser Gly Asn Ser Gly Ser Gly 
                965                 970         


<210> 69
<211> 991
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Glu Ala Ser Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val 
1               5                   10                  15      


Lys Ser Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala 
            20                  25                  30          


Glu Gly Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile 
        35                  40                  45              


Arg Ser Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys 
    50                  55                  60                  


Asn Ala Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly 
65                  70                  75                  80  


Tyr Ala Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln 
                85                  90                  95      


Asp Met Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu 
            100                 105                 110         


Ser Ala Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile 
        115                 120                 125             


Leu Asp Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr 
    130                 135                 140                 


Ala Val Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly 
145                 150                 155                 160 


Lys Phe Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His 
                165                 170                 175     


His Arg Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys 
            180                 185                 190         


Ala Gln Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly 
        195                 200                 205             


Tyr Phe Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile 
    210                 215                 220                 


Asn Tyr Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Ala His Trp Val Val Ala Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg 
                245                 250                 255     


Thr Trp Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser 
            260                 265                 270         


Thr Leu Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser 
        275                 280                 285             


Phe Ser Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu 
    290                 295                 300                 


Gly Ile Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile 
305                 310                 315                 320 


Met Lys Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu 
                325                 330                 335     


Val Met Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys 
            340                 345                 350         


Val Phe Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val 
        355                 360                 365             


Ile Tyr Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn 
    370                 375                 380                 


Lys Ser Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe 
385                 390                 395                 400 


Val Ile Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu 
                405                 410                 415     


Tyr Tyr Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met 
            420                 425                 430         


His Asn Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys 
        435                 440                 445             


Lys Asp Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val 
    450                 455                 460                 


Ser Ala Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly 
465                 470                 475                 480 


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn 
                485                 490                 495     


Ile Gln Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys 
            500                 505                 510         


Phe Val Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp 
        515                 520                 525             


Glu Leu Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala 
    530                 535                 540                 


Asp Ala Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr 
545                 550                 555                 560 


Asn Leu Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu 
                565                 570                 575     


Asp Glu Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn 
            580                 585                 590         


Phe Ile Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile 
        595                 600                 605             


Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala 
    610                 615                 620                 


Val Val Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln 
625                 630                 635                 640 


Gly Gln Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile 
                645                 650                 655     


Gly Lys Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr 
            660                 665                 670         


Lys Ile Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser 
        675                 680                 685             


Val Ile Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys 
    690                 695                 700                 


Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn 
705                 710                 715                 720 


Ile Val Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu 
                725                 730                 735     


Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys 
            740                 745                 750         


Lys Leu Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly 
        755                 760                 765             


Ile Asp Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met 
    770                 775                 780                 


Ala Glu Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro 
785                 790                 795                 800 


Lys Leu Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu 
                805                 810                 815     


Glu Phe Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn 
            820                 825                 830         


Ala Tyr Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu 
        835                 840                 845             


Leu Arg Ile Asp Asn Lys Thr Cys Thr Leu Phe Ala Asn Lys Ala Val 
    850                 855                 860                 


Ala Leu Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala 
865                 870                 875                 880 


Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile 
                885                 890                 895     


Ile Met Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr 
            900                 905                 910         


Phe Asp Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys 
        915                 920                 925             


Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu 
    930                 935                 940                 


Ser Ile Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys 
945                 950                 955                 960 


Glu Lys Lys Lys Val Ser Gly Asn Ser Gly Ser Gly Pro Lys Lys Lys 
                965                 970                 975     


Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            980                 985                 990     


<210> 70
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Ile Trp Leu Thr Ala Leu Lys Phe Leu Gly Lys His Ala Ala Lys His 
1               5                   10                  15      


Glu Ala Lys Gln Gln Leu Ser Lys Leu 
            20                  25  


<210> 71
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Ile Trp Leu Thr Ala Leu Lys Phe Leu Gly Lys His Ala Ala Lys His 
1               5                   10                  15      


Glu Ala Lys Gln Gln Leu Ser Lys Leu Asn Ala Val Gly Gln Asp Thr 
            20                  25                  30          


Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val Val Val 
        35                  40                  45              


Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser Leu Ile 
    50                  55                  60                  


Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
65                  70                  75  


<210> 72
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 73
<211> 80
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala Asn Ala 
            20                  25                  30          


Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
        35                  40                  45              


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
    50                  55                  60                  


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
65                  70                  75                  80  


<210> 74
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25      


<210> 75
<211> 76
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys Ala Asn Ala Val Gly Gln Asp 
            20                  25                  30          


Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val Val 
        35                  40                  45              


Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser Leu 
    50                  55                  60                  


Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
65                  70                  75      


<210> 76
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser 
1               5                   10                  15      


Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val 
            20                  25                  30          


Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys 
        35                  40                  45              


Pro Arg 
    50  


<210> 77
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 77
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys His Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 78
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 78
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys Asn Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 79
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 79
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys Asn Cys Ser Val His Val 
            20                  25                  30          


Ser Lys 
        


<210> 80
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 80
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Val Leu 
1               5                   10                  15      


Met Gly Cys Asn Leu Lys Thr Ala Thr Cys Asn Cys Ser Val His Val 
            20                  25                  30          


Ser Lys 
        


<210> 81
<211> 34
<212> PRT
<213> Streptococcus hyointestinalis

<400> 81
Phe Thr Ser Ile Ser Met Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Thr Cys Asn Tyr Lys Thr Ala Thr Cys His Cys Ser Ile Lys Val 
            20                  25                  30          


Ser Lys 
        


<210> 82
<211> 31
<212> PRT
<213> Streptococcus uberis

<400> 82
Ile Thr Ser Lys Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ile Leu 
1               5                   10                  15      


Met Thr Cys Pro Leu Lys Thr Ala Thr Cys Gly Cys His Phe Gly 
            20                  25                  30      


<210> 83
<211> 31
<212> PRT
<213> Streptococcus uberis

<400> 83
Val Thr Ser Lys Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ile Leu 
1               5                   10                  15      


Met Thr Cys Pro Leu Lys Thr Ala Thr Cys Gly Cys His Phe Gly 
            20                  25                  30      


<210> 84
<211> 31
<212> PRT
<213> Streptococcus galloyticus

<400> 84
Val Thr Ser Lys Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ile Leu 
1               5                   10                  15      


Met Thr Cys Ala Ile Lys Thr Ala Thr Cys Gly Cys His Phe Gly 
            20                  25                  30      


<210> 85
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 85
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys His Cys Ala Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 86
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 86
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys His Cys Asp Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 87
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 87
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys His Cys Glu Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 88
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 88
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Lys Thr Ala Thr Cys His Cys Gly Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 89
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 89
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Thr Thr Ala Thr Cys His Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 90
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 90
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Pro Met Lys Thr Ala Thr Cys His Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 91
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 91
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Val Lys Thr Ala Thr Cys His Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 92
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 92
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Met Ser Thr Ala Thr Cys His Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 93
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 93
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Lys Met Lys Thr Ala Thr Cys Asn Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 94
<211> 34
<212> PRT
<213> Lactococcus lactis

<400> 94
Ile Thr Ser Ile Ser Leu Cys Thr Pro Gly Cys Lys Thr Gly Ala Leu 
1               5                   10                  15      


Met Gly Cys Asn Lys Lys Thr Ala Thr Cys Asn Cys Ser Ile His Val 
            20                  25                  30          


Ser Lys 
        


<210> 95
<211> 397
<212> PRT
<213> Adeno-associated virus - 2

<400> 95
Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
    50                  55                  60                  


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
                245                 250                 255     


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
            260                 265                 270         


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
    290                 295                 300                 


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
305                 310                 315                 320 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
                325                 330                 335     


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
            340                 345                 350         


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
        355                 360                 365             


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
    370                 375                 380                 


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
385                 390                 395         


<210> 96
<211> 621
<212> PRT
<213> Adeno-associated virus - 2

<400> 96
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210> 97
<211> 735
<212> PRT
<213> Adeno-associated virus - 2

<400> 97
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 98
<211> 597
<212> PRT
<213> Adeno-associated virus - 2

<400> 98
Ala Pro Gly Lys Lys Arg Pro Val Glu His Ser Pro Val Glu Pro Asp 
1               5                   10                  15      


Ser Ser Ser Gly Thr Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg 
            20                  25                  30          


Leu Asn Phe Gly Gln Thr Gly Asp Ala Asp Ser Val Pro Asp Pro Gln 
        35                  40                  45              


Pro Leu Gly Gln Pro Pro Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr 
    50                  55                  60                  


Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
65                  70                  75                  80  


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
                85                  90                  95      


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
            100                 105                 110         


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
        115                 120                 125             


Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
    130                 135                 140                 


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
145                 150                 155                 160 


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
                165                 170                 175     


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
            180                 185                 190         


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
        195                 200                 205             


Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
    210                 215                 220                 


Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
225                 230                 235                 240 


Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
                245                 250                 255     


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
            260                 265                 270         


Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
        275                 280                 285             


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
    290                 295                 300                 


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
305                 310                 315                 320 


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
                325                 330                 335     


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
            340                 345                 350         


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
        355                 360                 365             


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
    370                 375                 380                 


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
385                 390                 395                 400 


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
                405                 410                 415     


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
            420                 425                 430         


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
        435                 440                 445             


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
    450                 455                 460                 


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
465                 470                 475                 480 


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
                485                 490                 495     


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
            500                 505                 510         


Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
        515                 520                 525             


Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
    530                 535                 540                 


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
545                 550                 555                 560 


Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
                565                 570                 575     


Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
            580                 585                 590         


Leu Thr Arg Asn Leu 
        595         


<210> 99
<211> 533
<212> PRT
<213> Adeno-associated virus - 2

<400> 99
Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
    50                  55                  60                  


Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
        115                 120                 125             


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
    130                 135                 140                 


Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
                165                 170                 175     


Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
        195                 200                 205             


Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
                245                 250                 255     


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
            260                 265                 270         


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
        275                 280                 285             


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
    290                 295                 300                 


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
305                 310                 315                 320 


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
            340                 345                 350         


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
        355                 360                 365             


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
    370                 375                 380                 


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
385                 390                 395                 400 


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
    450                 455                 460                 


Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
465                 470                 475                 480 


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
                485                 490                 495     


Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
            500                 505                 510         


Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
        515                 520                 525             


Leu Thr Arg Asn Leu 
    530             


<210> 100
<211> 143
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 100
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcuuuu uuu                                              143


<210> 101
<211> 199
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 101
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcggga gcacaugagg aucacccaug ugcgacuccc acagucacug      180

gggagucuuc ccuuuuuuu                                                   199


<210> 102
<211> 149
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 102
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcggga gcacaugagg aucacccaug ugcgacuccc      120

acagucacug gggagucuuc ccuuuuuuu                                        149


<210> 103
<211> 186
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 103
uucuagauca ucgaaacaug aggaucaccc auaucugcag ucgacaucga aacaugagga       60

ucacccaugu cugcagucga caucgaaaca ugaggaucac ccaugucugc agucgacauc      120

gaaacaugag gaucacccau gucugcaguc gacaucgaaa ucgauaagcu ucagaucaga      180

uccuag                                                                 186


<210> 104
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
acaugaggau cacccaugu                                                    19


<210> 105
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
acaugaggau cacccauau                                                    19


<210> 106
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
ccacagucac uggg                                                         14


<210> 107
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
acaugaggau cacccauguc ugcagggccu agcaaguuaa aauaaggcua guccguuauc       60

aacuuggcca acaugaggau cacccaugu                                         89


<210> 108
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 108
guuuuagagc uaggccggag cagacgauau ggcgucgcuc cggccuagca aguuaaaaua       60

aggcuagucc guuaucaacu uggccggagc agacgauaug gcgucgcucc ggccaagugg      120

caccgagucg gugcuuuuuu u                                                141


<210> 109
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
gccggagcag acgauauggc gucgcuccgg cc                                     32


<210> 110
<211> 112
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 110
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugccuga augccugcga gcaucuuuuu uu              112


<210> 111
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
cugaaugccu gcgagcauc                                                    19


<210> 112
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
gaagaagctg caggaggt                                                     18


<210> 113
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gctggagggg aagtggtc                                                     18


<210> 114
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
gaagaagctg caggaggtgc tggaggggaa gtggtc                                 36


<210> 115
<211> 346
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 115
tgaagaagct gcaggaggtg ctggagggga agtggtccgg atcttgaaga agctgcagga       60

ggtgctggag gggaagtggt ccggatcttg aagaagctgc aggaggtgct ggaggggaag      120

tggtccggat cttgaagaag ctgcaggagg tgctggaggg gaagtggtcc ggatcttgaa      180

gaagctgcag gaggtgctgg aggggaagtg gtccggatct tgaagaagct gcaggaggtg      240

ctggagggga agtggtccgg atcttgaaga agctgcagga ggtgctggag gggaagtggt      300

ccggatcttg aagaagctgc aggaggtgct ggaggggaag tggtcc                     346


<210> 116
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
gtagatgga                                                                9


<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
cggcgtagcc gatgtcgcgc                                                   20


<210> 118
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
aagggttca                                                                9


<210> 119
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 119
gcgtgggcg                                                                9


<210> 120
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
aagggttcag cgtgggcg                                                     18


<210> 121
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 121
aagggttcag gcgtgggcg                                                    19


<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 122
aagggttcag tgcgtgggcg                                                   20


<210> 123
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 123
gatccgccac aacatcgagg acggca                                            26


