                         SEQUENCE LISTING

<110>  bluebird bio, Inc.
       Friedman, Kevin
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER

<130>  BLUE-123.PC

<150>  US 62/861,838
<151>  2019-06-14

<150>  US 62/991,314
<151>  2020-03-18

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-01 CDRL1

<400>  1

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-01 CDRL2

<400>  2

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-01 CDRL3

<400>  3

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-01 CDRH1

<400>  4

Gly Tyr Thr Phe Ser Thr Ser Trp Met Asn 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-01 CDRH2

<400>  5

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-01 CDRH3

<400>  6

Phe Tyr Tyr Gly Asn Thr Phe Ala Met Asp Tyr 
1               5                   10      


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Seqauence

<220>
<223>  Made in Lab - anti-CD79A-01 Light chain

<400>  7

Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Seqauence

<220>
<223>  Made in Lab - anti-CD79A-01 Heavy chain

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Thr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Glu Arg Phe Tyr Tyr Gly Asn Thr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-10 CDRL1

<400>  9

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-10 CDRL2

<400>  10

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-10 CDRL3

<400>  11

Ser Gln Ser Thr His Val Pro Pro Tyr Thr 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-19 CDRH1

<400>  12

Gly Tyr Ala Phe Ser Phe Ser Trp Met Asn 
1               5                   10  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-10 CDRH2

<400>  13

Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD79A-10 CDRH3

<400>  14

Trp Val Tyr Ser Gly Asn Asn Tyr Ala Val Asp Tyr 
1               5                   10          


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Seqauence

<220>
<223>  Made in Lab - anti-CD79A-10 Light chain

<400>  15

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Seqauence

<220>
<223>  Made in Lab - anti-CD79A-10 Heavy chain

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ala Phe Ser Phe Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Trp Gly Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Val Tyr Ser Gly Asn Asn Tyr Ala Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_HL CAR construct

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Ser Thr Ser Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
65                  70                  75                  80  


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Glu Arg Phe Tyr Tyr Gly Asn Thr Phe Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Met 
145                 150                 155                 160 


Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro 
                245                 250                 255     


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  18
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR construct

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Ser Thr Ser Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
        195                 200                 205             


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Glu Arg Phe Tyr Tyr Gly Asn Thr Phe Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  19
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR construct

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Ala Phe Ser Phe Ser Trp Met Asn Trp Val Lys Trp Gly Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn 
65                  70                  75                  80  


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Arg Trp Val Tyr Ser Gly Asn Asn Tyr Ala 
        115                 120                 125             


Val Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
                245                 250                 255     


Pro Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  20
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_LH CAR construct

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Tyr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
                165                 170                 175     


Ala Phe Ser Phe Ser Trp Met Asn Trp Val Lys Trp Gly Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn 
        195                 200                 205             


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Ala Arg Trp Val Tyr Ser Gly Asn Asn Tyr Ala 
                245                 250                 255     


Val Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  21
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_HL CAR polynucleotide construct

<400>  21
atggcacttc cagtgactgc attgttgttg cccctggccc tgctgcttca cgccgcaagg       60

ccccaggtcc agcttcagca gtccggacca gagttggtga aacctggggc atcagtcaag      120

attagctgca aggcatcagg gtacaccttc agcactagtt ggatgaattg ggtgaagcag      180

cggcctggcc aggggttgga gtggatcgga cgcatctacc caggggatgg cgatacaaac      240

tacaacggaa agtttaaagg taaggctact ttgaccgctg acaaatcatc aaacacggca      300

tatatgcaac tgtctagcct cacatctgtc gactctgccg tctacttttg cgagcgattc      360

tactatggca acacttttgc catggactac tgggggcagg ggacatcagt aacagttagt      420

tctggagggg gcggttccgg gggcggggga tccggagggg gaggcagtga tgtgctgatg      480

acccagatac cgttgtcact cccggtctca ctgggtgacc aggcaagcat cagctgcagg      540

agcagccagt ccatcgtgca ctctaacgga aatacctacc tggagtggta tctgcagaaa      600

cctggccagt cccctaagtt gttgatttac aaagtttcaa accgatttag tggagttccc      660

gataggtttt ccggttccgg gagcggtaca gacttcaccc tgaagataag tcgggttgag      720

gctgaagacc tgggagtata ttattgcttt cagggcagcc acgtaccatt cacatttggg      780

agtggaacca aactggagat caaaagaacc acaacacctg ctccaaggcc ccccacaccc      840

gctccaacta tagccagcca accattgagc ctcagacctg aagcttgcag gcccgcagca      900

ggaggcgccg tccatacgcg aggcctggac ttcgcgtgtg atatttatat ttgggcccct      960

ttggccggaa catgtggggt gttgcttctc tcccttgtga tcactctgta ttgtaagcgc     1020

gggagaaaga agctcctgta catcttcaag cagcctttta tgcgacctgt gcaaaccact     1080

caggaagaag atgggtgttc atgccgcttc cccgaggagg aagaaggagg gtgtgaactg     1140

agggtgaaat tttctagaag cgccgatgct cccgcatatc agcagggtca gaatcagctc     1200

tacaatgaat tgaatctcgg caggcgagaa gagtacgatg ttctggacaa gagacggggc     1260

agggatcccg agatgggggg aaagccccgg agaaaaaatc ctcaggaggg gttgtacaat     1320

gagctgcaga aggacaagat ggctgaagcc tatagcgaga tcggaatgaa aggcgaaaga     1380

cgcagaggca aggggcatga cggtctgtac cagggtctct ctacagccac caaggacact     1440

tatgatgcgt tgcatatgca agccttgcca ccccgctaa                            1479


<210>  22
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR polynucleotide construct

<400>  22
atggctctgc ctgtgacggc cctgcttttg cccctcgccc tgcttctgca tgccgcgaga       60

cccgacgtgt tgatgaccca aataccgctt agtctgcctg tatctcttgg ggaccaggct      120

agcatctcat gccgcagcag tcaatccatt gtgcactcaa atgggaacac ctatttggag      180

tggtatctgc aaaaaccggg acagtctccg aaactgctga tatacaaagt aagcaacagg      240

ttcagcggag ttcctgacag attcagcgga agcggttctg gaactgactt tacacttaag      300

atctctcgcg ttgaggcgga ggacctgggc gtgtattact gttttcaagg atcccacgtc      360

ccgtttacat tcggatcagg caccaagctg gagatcaagc gcggtggcgg gggttctggc      420

gggggcggat ccggaggcgg cggatcccag gtgcagctgc agcagtctgg accagaactg      480

gttaagcccg gagcttcagt taagatttcc tgtaaggctt caggctatac attttccact      540

tcttggatga actgggtgaa acagcgccct ggccaggggc tggaatggat cggacggatc      600

tatcccggcg atggagacac taattataac ggtaagttca aagggaaggc caccctcacg      660

gccgacaagt cctccaatac agcgtacatg caactcagtt ccctgaccag cgttgatagc      720

gcagtttact tctgtgagcg cttctattac ggaaacacct tcgctatgga ttactggggt      780

caggggacct ccgtgaccgt gtcctctacc acaacacctg ctccaaggcc ccccacaccc      840

gctccaacta tagccagcca accattgagc ctcagacctg aagcttgcag gcccgcagca      900

ggaggcgccg tccatacgcg aggcctggac ttcgcgtgtg atatttatat ttgggcccct      960

ttggccggaa catgtggggt gttgcttctc tcccttgtga tcactctgta ttgtaagcgc     1020

gggagaaaga agctcctgta catcttcaag cagcctttta tgcgacctgt gcaaaccact     1080

caggaagaag atgggtgttc atgccgcttc cccgaggagg aagaaggagg gtgtgaactg     1140

agggtgaaat tttctagaag cgccgatgct cccgcatatc agcagggtca gaatcagctc     1200

tacaatgaat tgaatctcgg caggcgagaa gagtacgatg ttctggacaa gagacggggc     1260

agggatcccg agatgggggg aaagccccgg agaaaaaatc ctcaggaggg gttgtacaat     1320

gagctgcaga aggacaagat ggctgaagcc tatagcgaga tcggaatgaa aggcgaaaga     1380

cgcagaggca aggggcatga cggtctgtac cagggtctct ctacagccac caaggacact     1440

tatgatgcgt tgcatatgca agccttgcca ccccgctaa                            1479


<210>  23
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR polynucleotide construct

<400>  23
atggctctgc cagtgactgc gctgctgctg cccctcgctc ttctgctgca cgccgctcgg       60

ccacaggtcc aactgcaaca gagcggcccc gagctggtaa aacccggggc ctccgtaaaa      120

atatcctgca agaccagcgg ctatgccttt tcattctcct ggatgaactg ggtgaagtgg      180

ggacccggtc agggacttga gtggatcggg cgaatctatc ccggaaacgg ggacacgaat      240

tacaacggca aatttaaagg caaggctact ctgactgctg acaaaagtag caacaccgcc      300

tacatgcagt tgtcctcttt gacatcagta gactctgcag tgtatttttg cgcccggtgg      360

gtttactccg gaaataacta cgcggttgac tattggggac agggcacctc cgtgacagtg      420

tcttctggcg gcgggggatc aggtggcggc gggtctgggg gtggagggag cgacgtggtt      480

atgacccaga cccctttgag cctgcccgtg agccttggcg accaagcctc catctcttgc      540

cggtcctctc aatcactggt gcacagtaac gggaatactt atctccactg gtatttgcaa      600

aagcccggtc agtctcctaa gcttctgatc tataaggtgt ccaaccgctt ttctggagtg      660

cccgatagat tttccggatc tggatccgga acagacttca cattgaagat tagtagagtc      720

gaagcggagg acttgggtgt ttatttttgt tcccagagta cccacgtgcc tccatacacg      780

tttggaggtg gaaccaaact tgaaattaag accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgct aa                        1482


<210>  24
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_LH CAR polynucleotide construct

<400>  24
atggccctgc cagtaacagc actgctcctt cctctcgcac tcctcctgca cgcagcaaga       60

ccagatgtcg tgatgactca gacacctctt agcttgcccg tctccttggg tgatcaggct      120

agcatttcat gtagatcaag ccagagcttg gtacattcaa atggcaatac ctacctgcac      180

tggtatctcc agaaacctgg ccagagccca aaattgctta tctataaagt tagtaacaga      240

ttctccgggg tcccagatcg attttccggc tcaggctcag gcacggattt taccctgaag      300

atctcacgag tcgaggcaga agatcttggc gtgtactttt gttcccagag tacccacgta      360

cccccttaca cattcggagg agggaccaag ttggagatca aaggaggggg gggcagtggg      420

gggggcggtt ccggaggggg aggaagccaa gtacaactgc aacaaagcgg acccgagctc      480

gtcaaacctg gtgctagcgt caaaatttcc tgtaagacca gcggctacgc ttttagcttt      540

tcttggatga actgggtgaa atgggggccg gggcagggcc tggagtggat aggacgaatt      600

tatcccggga atggggatac aaattacaat ggtaaattca aggggaaagc cacactgact      660

gcagataaaa gctccaacac ggcatacatg cagctcagct ccctcacttc tgtggattct      720

gctgtttact tttgtgccag gtgggtttac tctggtaata actatgccgt ggattactgg      780

gggcaaggca cctctgttac agtgagttcc accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgct aa                        1482


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD20 CDRL1

<400>  25

Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
1               5                   10  


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD20 CDRL2

<400>  26

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD20 CDRL3

<400>  27

Gln Gln Trp Ser Phe Asn Pro Pro Thr 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD20 CDRH1

<400>  28

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD20 CDRH2

<400>  29

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-CD20 CDRH3

<400>  30

Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val 
1               5                   10              


<210>  31
<211>  106
<212>  PRT
<213>  Artificial Seqauence

<220>
<223>  Made in Lab - anti-CD20 Light chain

<400>  31

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Seqauence

<220>
<223>  Made in Lab - anti-CD20 Heavy chain

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD20 L-H CCR construct

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp 
        115                 120                 125             


Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
                165                 170                 175     


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp 
            180                 185                 190         


Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser 
    370                 


<210>  34
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD20 L-H CCR polynucleotide construct

<400>  34
atggcgctcc ctgtcacagc actgctcctt ccgctggctc tgcttctgca cgctgctagg       60

ccagaagttc aactccagca gagcggcgca gagctcgtga agcccggagc ttcagtgaag      120

atgtcatgta aagcctcagg atatactttt acttcataca atatgcactg ggtgaagcag      180

acaccgggtc agggacttga gtggatcggc gcaatatacc ccggaaatgg agacaccagc      240

tacaaccaga aatttaaggg aaaagccacc ctgacagccg ataaatcctc cagtacggct      300

tacatgcaat tgagctcact gactagcgag gactccgcag attattattg tgctagaagt      360

aactactacg gcagctccta ttggtttttt gacgtgtggg gggcgggcac caccgttaca      420

gtcagcagtg gcggcggagg ttcaggtggg gggggctctg gaggcggtgg gtctgatatc      480

gtcttgactc aaagcccagc gatattgtca gcctcccctg gagagaaagt gactatgacc      540

tgcagggcta gcagctctgt taattatatg gattggtatc agaagaaacc tggcagctcc      600

cctaagccct ggatttatgc tacatcaaat ctcgcctcag gggtgccagc caggttcagt      660

ggatccggca gtggcaccag ctatagcctg acaatctcaa gggtcgaagc agaggacgcc      720

gcaacatatt attgtcagca atggagcttt aatcccccca catttggcgg aggaaccaag      780

ttggagatca agaccacgac cccggcaccc cggccaccta caccagcccc tacaattgct      840

agccagcccc tgagccttag gccagaagcc tgtagacccg ccgccggcgg tgcggttcac      900

acccggggac tcgacttcgc ctgtgatata tatatctggg cacccctggc cggcacatgt      960

ggagtgcttc tgctgtcctt ggtcattacc ctctactgca gatctaaaag atccagactg     1020

cttcattctg actatatgaa tatgactcct agacggcctg ggcccaccag gaagcactac     1080

cagccatacg ccccaccacg agattttgcc gcttatcggt cctaa                     1125


<210>  35
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD20 H-L CCR construct

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        35                  40                  45              


Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro 
    50                  55                  60                  


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
                165                 170                 175     


His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Ala 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser 
    370                 


<210>  36
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD20 H-L CCR polynucleotide construct

<400>  36
atggcgctcc ctgtcacagc actgctcctt ccgctggctc tgcttctgca cgctgctagg       60

ccagatatcg tcttgactca aagcccagcg atattgtcag cctcccctgg agagaaagtg      120

actatgacct gcagggctag cagctctgtt aattatatgg attggtatca gaagaaacct      180

ggcagctccc ctaagccctg gatttatgct acatcaaatc tcgcctcagg ggtgccagcc      240

aggttcagtg gatccggcag tggcaccagc tatagcctga caatctcaag ggtcgaagca      300

gaggacgccg caacatatta ttgtcagcaa tggagcttta atccccccac atttggcgga      360

ggaaccaagt tggagatcaa gggcggcgga ggttcaggtg gggggggctc tggaggcggt      420

gggtctgaag ttcaactcca gcagagcggc gcagagctcg tgaagcccgg agcttcagtg      480

aagatgtcat gtaaagcctc aggatatact tttacttcat acaatatgca ctgggtgaag      540

cagacaccgg gtcagggact tgagtggatc ggcgcaatat accccggaaa tggagacacc      600

agctacaacc agaaatttaa gggaaaagcc accctgacag ccgataaatc ctccagtacg      660

gcttacatgc aattgagctc actgactagc gaggactccg cagattatta ttgtgctaga      720

agtaactact acggcagctc ctattggttt tttgacgtgt ggggggcggg caccaccgtt      780

acagtcagca gtaccacgac cccggcaccc cggccaccta caccagcccc tacaattgct      840

agccagcccc tgagccttag gccagaagcc tgtagacccg ccgccggcgg tgcggttcac      900

acccggggac tcgacttcgc ctgtgatata tatatctggg cacccctggc cggcacatgt      960

ggagtgcttc tgctgtcctt ggtcattacc ctctactgca gatctaaaag atccagactg     1020

cttcattctg actatatgaa tatgactcct agacggcctg ggcccaccag gaagcactac     1080

cagccatacg ccccaccacg agattttgcc gcttatcggt cctaa                     1125


<210>  37
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR - T2A - anti-CD20 CCR 
       construct

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Ser Thr Ser Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
        195                 200                 205             


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Glu Arg Phe Tyr Tyr Gly Asn Thr Phe Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu 
                485                 490                 495     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
    530                 535                 540                 


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
545                 550                 555                 560 


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
                565                 570                 575     


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
            580                 585                 590         


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
        595                 600                 605             


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
    610                 615                 620                 


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
625                 630                 635                 640 


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            660                 665                 670         


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
        675                 680                 685             


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
    690                 695                 700                 


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
705                 710                 715                 720 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
                725                 730                 735     


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
            740                 745                 750         


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
        755                 760                 765             


Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
    770                 775                 780                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
785                 790                 795                 800 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                805                 810                 815     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            820                 825                 830         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
        835                 840                 845             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    850                 855                 860                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
865                 870                 875                 880 


Asp Phe Ala Ala Tyr Arg Ser 
                885         


<210>  38
<211>  2664
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR - T2A - CD20 CCR 
       polynucleotide construct

<400>  38
atggctctgc ctgtgacggc cctgcttttg cccctcgccc tgcttctgca tgccgcgaga       60

cccgacgtgt tgatgaccca aataccgctt agtctgcctg tatctcttgg ggaccaggct      120

agcatctcat gccgcagcag tcaatccatt gtgcactcaa atgggaacac ctatttggag      180

tggtatctgc aaaaaccggg acagtctccg aaactgctga tatacaaagt aagcaacagg      240

ttcagcggag ttcctgacag attcagcgga agcggttctg gaactgactt tacacttaag      300

atctctcgcg ttgaggcgga ggacctgggc gtgtattact gttttcaagg atcccacgtc      360

ccgtttacat tcggatcagg caccaagctg gagatcaagc gcggtggcgg gggttctggc      420

gggggcggat ccggaggcgg cggatcccag gtgcagctgc agcagtctgg accagaactg      480

gttaagcccg gagcttcagt taagatttcc tgtaaggctt caggctatac attttccact      540

tcttggatga actgggtgaa acagcgccct ggccaggggc tggaatggat cggacggatc      600

tatcccggcg atggagacac taattataac ggtaagttca aagggaaggc caccctcacg      660

gccgacaagt cctccaatac agcgtacatg caactcagtt ccctgaccag cgttgatagc      720

gcagtttact tctgtgagcg cttctattac ggaaacacct tcgctatgga ttactggggt      780

caggggacct ccgtgaccgt gtcctctacc acaacacctg ctccaaggcc ccccacaccc      840

gctccaacta tagccagcca accattgagc ctcagacctg aagcttgcag gcccgcagca      900

ggaggcgccg tccatacgcg aggcctggac ttcgcgtgtg atatttatat ttgggcccct      960

ttggccggaa catgtggggt gttgcttctc tcccttgtga tcactctgta ttgtaagcgc     1020

gggagaaaga agctcctgta catcttcaag cagcctttta tgcgacctgt gcaaaccact     1080

caggaagaag atgggtgttc atgccgcttc cccgaggagg aagaaggagg gtgtgaactg     1140

agggtgaaat tttctagaag cgccgatgct cccgcatatc agcagggtca gaatcagctc     1200

tacaatgaat tgaatctcgg caggcgagaa gagtacgatg ttctggacaa gagacggggc     1260

agggatcccg agatgggggg aaagccccgg agaaaaaatc ctcaggaggg gttgtacaat     1320

gagctgcaga aggacaagat ggctgaagcc tatagcgaga tcggaatgaa aggcgaaaga     1380

cgcagaggca aggggcatga cggtctgtac cagggtctct ctacagccac caaggacact     1440

tatgatgcgt tgcatatgca agccttgcca ccccgcgggt ccggtgaggg acgaggatct     1500

ctgttaacgt gtggcgatgt cgaggaaaat cctggcccaa tggcgctccc tgtcacagca     1560

ctgctccttc cgctggctct gcttctgcac gctgctaggc cagaagttca actccagcag     1620

agcggcgcag agctcgtgaa gcccggagct tcagtgaaga tgtcatgtaa agcctcagga     1680

tatactttta cttcatacaa tatgcactgg gtgaagcaga caccgggtca gggacttgag     1740

tggatcggcg caatataccc cggaaatgga gacaccagct acaaccagaa atttaaggga     1800

aaagccaccc tgacagccga taaatcctcc agtacggctt acatgcaatt gagctcactg     1860

actagcgagg actccgcaga ttattattgt gctagaagta actactacgg cagctcctat     1920

tggttttttg acgtgtgggg ggcgggcacc accgttacag tcagcagtgg cggcggaggt     1980

tcaggtgggg ggggctctgg aggcggtggg tctgatatcg tcttgactca aagcccagcg     2040

atattgtcag cctcccctgg agagaaagtg actatgacct gcagggctag cagctctgtt     2100

aattatatgg attggtatca gaagaaacct ggcagctccc ctaagccctg gatttatgct     2160

acatcaaatc tcgcctcagg ggtgccagcc aggttcagtg gatccggcag tggcaccagc     2220

tatagcctga caatctcaag ggtcgaagca gaggacgccg caacatatta ttgtcagcaa     2280

tggagcttta atccccccac atttggcgga ggaaccaagt tggagatcaa gaccacgacc     2340

ccggcacccc ggccacctac accagcccct acaattgcta gccagcccct gagccttagg     2400

ccagaagcct gtagacccgc cgccggcggt gcggttcaca cccggggact cgacttcgcc     2460

tgtgatatat atatctgggc acccctggcc ggcacatgtg gagtgcttct gctgtccttg     2520

gtcattaccc tctactgcag atctaaaaga tccagactgc ttcattctga ctatatgaat     2580

atgactccta gacggcctgg gcccaccagg aagcactacc agccatacgc cccaccacga     2640

gattttgccg cttatcggtc ctaa                                            2664


<210>  39
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR - T2A - anti-CD20 CCR 
       construct

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Ala Phe Ser Phe Ser Trp Met Asn Trp Val Lys Trp Gly Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn 
65                  70                  75                  80  


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Arg Trp Val Tyr Ser Gly Asn Asn Tyr Ala 
        115                 120                 125             


Val Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Arg Ser Asp Val Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
                245                 250                 255     


Pro Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
                485                 490                 495     


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
        515                 520                 525             


Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala 
    530                 535                 540                 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
545                 550                 555                 560 


Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro 
                565                 570                 575     


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
            580                 585                 590         


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
        595                 600                 605             


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
    610                 615                 620                 


Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
625                 630                 635                 640 


Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
        675                 680                 685             


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
    690                 695                 700                 


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
705                 710                 715                 720 


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                725                 730                 735     


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
            740                 745                 750         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
        755                 760                 765             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
        835                 840                 845             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    850                 855                 860                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
865                 870                 875                 880 


Arg Asp Phe Ala Ala Tyr Arg Ser 
                885             


<210>  40
<211>  2667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR - T2A - anti-CD20 CCR 
       polynucleotide construct

<400>  40
atggctctgc cagtgactgc gctgctgctg cccctcgctc ttctgctgca cgccgctcgg       60

ccacaggtcc aactgcaaca gagcggcccc gagctggtaa aacccggggc ctccgtaaaa      120

atatcctgca agaccagcgg ctatgccttt tcattctcct ggatgaactg ggtgaagtgg      180

ggacccggtc agggacttga gtggatcggg cgaatctatc ccggaaacgg ggacacgaat      240

tacaacggca aatttaaagg caaggctact ctgactgctg acaaaagtag caacaccgcc      300

tacatgcagt tgtcctcttt gacatcagta gactctgcag tgtatttttg cgcccggtgg      360

gtttactccg gaaataacta cgcggttgac tattggggac agggcacctc cgtgacagtg      420

tcttctggcg gcgggggatc aggtggcggc gggtctgggg gtggaaggag cgacgtggtt      480

atgacccaga cccctttgag cctgcccgtg agccttggcg accaagcctc catctcttgc      540

cggtcctctc aatcactggt gcacagtaac gggaatactt atctccactg gtatttgcaa      600

aagcccggtc agtctcctaa gcttctgatc tataaggtgt ccaaccgctt ttctggagtg      660

cccgatagat tttccggatc tggatccggg acagacttca cattgaagat tagtagagtc      720

gaagcggagg acttgggtgt ttatttttgt tcccagagta cccacgtgcc tccatacacg      780

tttggaggtg gaaccaaact tgaaattaag accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgcg ggtccggtga gggacgagga     1500

tctctgttaa cgtgtggcga tgtcgaggaa aatcctggcc caatggcgct ccctgtcaca     1560

gcactgctcc ttccgctggc tctgcttctg cacgctgcta ggccagaagt tcaactccag     1620

cagagcggcg cagagctcgt gaagcccgga gcttcagtga agatgtcatg taaagcctca     1680

ggatatactt ttacttcata caatatgcac tgggtgaagc agacaccggg tcagggactt     1740

gagtggatcg gcgcaatata ccccggaaat ggagacacca gctacaacca gaaatttaag     1800

ggaaaagcca ccctgacagc cgataaatcc tccagtacgg cttacatgca attgagctca     1860

ctgactagcg aggactccgc agattattat tgtgctagaa gtaactacta cggcagctcc     1920

tattggtttt ttgacgtgtg gggggcgggc accaccgtta cagtcagcag tggcggcgga     1980

ggttcaggtg gggggggctc tggaggcggt gggtctgata tcgtcttgac tcaaagccca     2040

gcgatattgt cagcctcccc tggagagaaa gtgactatga cctgcagggc tagcagctct     2100

gttaattata tggattggta tcagaagaaa cctggcagct cccctaagcc ctggatttat     2160

gctacatcaa atctcgcctc aggggtgcca gccaggttca gtggatccgg cagtggcacc     2220

agctatagcc tgacaatctc aagggtcgaa gcagaggacg ccgcaacata ttattgtcag     2280

caatggagct ttaatccccc cacatttggc ggaggaacca agttggagat caagaccacg     2340

accccggcac cccggccacc tacaccagcc cctacaattg ctagccagcc cctgagcctt     2400

aggccagaag cctgtagacc cgccgccggc ggtgcggttc acacccgggg actcgacttc     2460

gcctgtgata tatatatctg ggcacccctg gccggcacat gtggagtgct tctgctgtcc     2520

ttggtcatta ccctctactg cagatctaaa agatccagac tgcttcattc tgactatatg     2580

aatatgactc ctagacggcc tgggcccacc aggaagcact accagccata cgccccacca     2640

cgagattttg ccgcttatcg gtcctaa                                         2667


<210>  41
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR-T2A-anti-CD20 CD28z CAR 
       construct

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Ser Thr Ser Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
        195                 200                 205             


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Glu Arg Phe Tyr Tyr Gly Asn Thr Phe Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu 
                485                 490                 495     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
    530                 535                 540                 


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
545                 550                 555                 560 


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
                565                 570                 575     


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
            580                 585                 590         


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
        595                 600                 605             


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
    610                 615                 620                 


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
625                 630                 635                 640 


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            660                 665                 670         


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
        675                 680                 685             


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
    690                 695                 700                 


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
705                 710                 715                 720 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
                725                 730                 735     


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
            740                 745                 750         


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
        755                 760                 765             


Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
    770                 775                 780                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
785                 790                 795                 800 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                805                 810                 815     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            820                 825                 830         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
        835                 840                 845             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    850                 855                 860                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
865                 870                 875                 880 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
                885                 890                 895     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            900                 905                 910         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        915                 920                 925             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    930                 935                 940                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
945                 950                 955                 960 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                965                 970                 975     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            980                 985                 990         


Met Gln Ala Leu Pro Pro Arg 
        995                 


<210>  42
<211>  3000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR-T2A-anti-CD20 CD28z CAR 
       polynucleotide construct

<400>  42
atggctctgc ctgtgacggc cctgcttttg cccctcgccc tgcttctgca tgccgcgaga       60

cccgacgtgt tgatgaccca aataccgctt agtctgcctg tatctcttgg ggaccaggct      120

agcatctcat gccgcagcag tcaatccatt gtgcactcaa atgggaacac ctatttggag      180

tggtatctgc aaaaaccggg acagtctccg aaactgctga tatacaaagt aagcaacagg      240

ttcagcggag ttcctgacag attcagcgga agcggttctg gaactgactt tacacttaag      300

atctctcgcg ttgaggcgga ggacctgggc gtgtattact gttttcaagg atcccacgtc      360

ccgtttacat tcggatcagg caccaagctg gagatcaagc gcggtggcgg gggttctggc      420

gggggcggat ccggaggcgg cggatcccag gtgcagctgc agcagtctgg accagaactg      480

gttaagcccg gagcttcagt taagatttcc tgtaaggctt caggctatac attttccact      540

tcttggatga actgggtgaa acagcgccct ggccaggggc tggaatggat cggacggatc      600

tatcccggcg atggagacac taattataac ggtaagttca aagggaaggc caccctcacg      660

gccgacaagt cctccaatac agcgtacatg caactcagtt ccctgaccag cgttgatagc      720

gcagtttact tctgtgagcg cttctattac ggaaacacct tcgctatgga ttactggggt      780

caggggacct ccgtgaccgt gtcctctacc acaacacctg ctccaaggcc ccccacaccc      840

gctccaacta tagccagcca accattgagc ctcagacctg aagcttgcag gcccgcagca      900

ggaggcgccg tccatacgcg aggcctggac ttcgcgtgtg atatttatat ttgggcccct      960

ttggccggaa catgtggggt gttgcttctc tcccttgtga tcactctgta ttgtaagcgc     1020

gggagaaaga agctcctgta catcttcaag cagcctttta tgcgacctgt gcaaaccact     1080

caggaagaag atgggtgttc atgccgcttc cccgaggagg aagaaggagg gtgtgaactg     1140

agggtgaaat tttctagaag cgccgatgct cccgcatatc agcagggtca gaatcagctc     1200

tacaatgaat tgaatctcgg caggcgagaa gagtacgatg ttctggacaa gagacggggc     1260

agggatcccg agatgggggg aaagccccgg agaaaaaatc ctcaggaggg gttgtacaat     1320

gagctgcaga aggacaagat ggctgaagcc tatagcgaga tcggaatgaa aggcgaaaga     1380

cgcagaggca aggggcatga cggtctgtac cagggtctct ctacagccac caaggacact     1440

tatgatgcgt tgcatatgca agccttgcca ccccgcgggt ccggtgaggg acgaggatct     1500

ctgttaacgt gtggcgatgt cgaggaaaat cctggcccaa tggcgctccc tgtcacagca     1560

ctgctccttc cgctggctct gcttctgcac gctgctaggc cagaagttca actccagcag     1620

agcggcgcag agctcgtgaa gcccggagct tcagtgaaga tgtcatgtaa agcctcagga     1680

tatactttta cttcatacaa tatgcactgg gtgaagcaga caccgggtca gggacttgag     1740

tggatcggcg caatataccc cggaaatgga gacaccagct acaaccagaa atttaaggga     1800

aaagccaccc tgacagccga taaatcctcc agtacggctt acatgcaatt gagctcactg     1860

actagcgagg actccgcaga ttattattgt gctagaagta actactacgg cagctcctat     1920

tggttttttg acgtgtgggg ggcgggcacc accgttacag tcagcagtgg cggcggaggt     1980

tcaggtgggg ggggctctgg aggcggtggg tctgatatcg tcttgactca aagcccagcg     2040

atattgtcag cctcccctgg agagaaagtg actatgacct gcagggctag cagctctgtt     2100

aattatatgg attggtatca gaagaaacct ggcagctccc ctaagccctg gatttatgct     2160

acatcaaatc tcgcctcagg ggtgccagcc aggttcagtg gatccggcag tggcaccagc     2220

tatagcctga caatctcaag ggtcgaagca gaggacgccg caacatatta ttgtcagcaa     2280

tggagcttta atccccccac atttggcgga ggaaccaagt tggagatcaa gaccacgacc     2340

ccggcacccc ggccacctac accagcccct acaattgcta gccagcccct gagccttagg     2400

ccagaagcct gtagacccgc cgccggcggt gcggttcaca cccggggact cgacttcgcc     2460

tgtgatatat atatctgggc acccctggcc ggcacatgtg gagtgcttct gctgtccttg     2520

gtcattaccc tctactgcag atctaaaaga tccagactgc ttcattctga ctatatgaat     2580

atgactccta gacggcctgg gcccaccagg aagcactacc agccatacgc cccaccacga     2640

gattttgccg cttatcggtc ccgggttaaa ttttctagga gcgccgacgc gccagcatac     2700

cagcagggcc agaaccagct ctacaacgag ctcaacctgg ggcgcaggga ggagtatgac     2760

gtgcttgaca agaggagagg ccgggatcca gagatgggcg ggaagcctag gcggaaaaac     2820

ccacaggagg ggttgtacaa cgagcttcaa aaggacaaaa tggccgaagc ctactctgaa     2880

ataggcatga agggcgaacg cagacgaggc aaaggccacg acggactgta tcaaggattg     2940

tctaccgcta caaaggatac ctacgacgca ctgcatatgc aggccctgcc tcctaggtaa     3000


<210>  43
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR-T2A-anti-CD20 CD28z CAR 
       construct

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Ala Phe Ser Phe Ser Trp Met Asn Trp Val Lys Trp Gly Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn 
65                  70                  75                  80  


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Arg Trp Val Tyr Ser Gly Asn Asn Tyr Ala 
        115                 120                 125             


Val Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Arg Ser Asp Val Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
                245                 250                 255     


Pro Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
                485                 490                 495     


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
        515                 520                 525             


Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala 
    530                 535                 540                 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
545                 550                 555                 560 


Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro 
                565                 570                 575     


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
            580                 585                 590         


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
        595                 600                 605             


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
    610                 615                 620                 


Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
625                 630                 635                 640 


Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
        675                 680                 685             


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
    690                 695                 700                 


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
705                 710                 715                 720 


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                725                 730                 735     


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
            740                 745                 750         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
        755                 760                 765             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
        835                 840                 845             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    850                 855                 860                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
865                 870                 875                 880 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                885                 890                 895     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            900                 905                 910         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        915                 920                 925             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    930                 935                 940                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
945                 950                 955                 960 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                965                 970                 975     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            980                 985                 990         


His Met Gln Ala Leu Pro Pro Arg  
        995                 1000 


<210>  44
<211>  3003
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR-T2A-anti-CD20 CD28z CAR 
       polynucleotide construct

<400>  44
atggctctgc cagtgactgc gctgctgctg cccctcgctc ttctgctgca cgccgctcgg       60

ccacaggtcc aactgcaaca gagcggcccc gagctggtaa aacccggggc ctccgtaaaa      120

atatcctgca agaccagcgg ctatgccttt tcattctcct ggatgaactg ggtgaagtgg      180

ggacccggtc agggacttga gtggatcggg cgaatctatc ccggaaacgg ggacacgaat      240

tacaacggca aatttaaagg caaggctact ctgactgctg acaaaagtag caacaccgcc      300

tacatgcagt tgtcctcttt gacatcagta gactctgcag tgtatttttg cgcccggtgg      360

gtttactccg gaaataacta cgcggttgac tattggggac agggcacctc cgtgacagtg      420

tcttctggcg gcgggggatc aggtggcggc gggtctgggg gtggaaggag cgacgtggtt      480

atgacccaga cccctttgag cctgcccgtg agccttggcg accaagcctc catctcttgc      540

cggtcctctc aatcactggt gcacagtaac gggaatactt atctccactg gtatttgcaa      600

aagcccggtc agtctcctaa gcttctgatc tataaggtgt ccaaccgctt ttctggagtg      660

cccgatagat tttccggatc tggatccggg acagacttca cattgaagat tagtagagtc      720

gaagcggagg acttgggtgt ttatttttgt tcccagagta cccacgtgcc tccatacacg      780

tttggaggtg gaaccaaact tgaaattaag accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgcg ggtccggtga gggacgagga     1500

tctctgttaa cgtgtggcga tgtcgaggaa aatcctggcc caatggcgct ccctgtcaca     1560

gcactgctcc ttccgctggc tctgcttctg cacgctgcta ggccagaagt tcaactccag     1620

cagagcggcg cagagctcgt gaagcccgga gcttcagtga agatgtcatg taaagcctca     1680

ggatatactt ttacttcata caatatgcac tgggtgaagc agacaccggg tcagggactt     1740

gagtggatcg gcgcaatata ccccggaaat ggagacacca gctacaacca gaaatttaag     1800

ggaaaagcca ccctgacagc cgataaatcc tccagtacgg cttacatgca attgagctca     1860

ctgactagcg aggactccgc agattattat tgtgctagaa gtaactacta cggcagctcc     1920

tattggtttt ttgacgtgtg gggggcgggc accaccgtta cagtcagcag tggcggcgga     1980

ggttcaggtg gggggggctc tggaggcggt gggtctgata tcgtcttgac tcaaagccca     2040

gcgatattgt cagcctcccc tggagagaaa gtgactatga cctgcagggc tagcagctct     2100

gttaattata tggattggta tcagaagaaa cctggcagct cccctaagcc ctggatttat     2160

gctacatcaa atctcgcctc aggggtgcca gccaggttca gtggatccgg cagtggcacc     2220

agctatagcc tgacaatctc aagggtcgaa gcagaggacg ccgcaacata ttattgtcag     2280

caatggagct ttaatccccc cacatttggc ggaggaacca agttggagat caagaccacg     2340

accccggcac cccggccacc tacaccagcc cctacaattg ctagccagcc cctgagcctt     2400

aggccagaag cctgtagacc cgccgccggc ggtgcggttc acacccgggg actcgacttc     2460

gcctgtgata tatatatctg ggcacccctg gccggcacat gtggagtgct tctgctgtcc     2520

ttggtcatta ccctctactg cagatctaaa agatccagac tgcttcattc tgactatatg     2580

aatatgactc ctagacggcc tgggcccacc aggaagcact accagccata cgccccacca     2640

cgagattttg ccgcttatcg gtcccgggtt aaattttcta ggagcgccga cgcgccagca     2700

taccagcagg gccagaacca gctctacaac gagctcaacc tggggcgcag ggaggagtat     2760

gacgtgcttg acaagaggag aggccgggat ccagagatgg gcgggaagcc taggcggaaa     2820

aacccacagg aggggttgta caacgagctt caaaaggaca aaatggccga agcctactct     2880

gaaataggca tgaagggcga acgcagacga ggcaaaggcc acgacggact gtatcaagga     2940

ttgtctaccg ctacaaagga tacctacgac gcactgcata tgcaggccct gcctcctagg     3000

taa                                                                   3003


<210>  45
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR-T2A-anti-CD20 BBz CAR 
       construct

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Ser Thr Ser Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
        195                 200                 205             


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Glu Arg Phe Tyr Tyr Gly Asn Thr Phe Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu 
                485                 490                 495     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
    530                 535                 540                 


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
545                 550                 555                 560 


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
                565                 570                 575     


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
            580                 585                 590         


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
        595                 600                 605             


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
    610                 615                 620                 


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
625                 630                 635                 640 


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            660                 665                 670         


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
        675                 680                 685             


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
    690                 695                 700                 


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
705                 710                 715                 720 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
                725                 730                 735     


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
            740                 745                 750         


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
        755                 760                 765             


Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
    770                 775                 780                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
785                 790                 795                 800 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                805                 810                 815     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            820                 825                 830         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        835                 840                 845             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    850                 855                 860                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
865                 870                 875                 880 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                885                 890                 895     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            900                 905                 910         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        915                 920                 925             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    930                 935                 940                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
945                 950                 955                 960 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                965                 970                 975     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            980                 985                 990         


His Met Gln Ala Leu Pro Pro Arg  
        995                 1000 


<210>  46
<211>  3003
<212>  DNA
<213>  Artificial Sequene

<220>
<223>  Made in Lab - anti-CD79A-01_LH CAR-T2A-anti-CD20 BBz CAR 
       polynucleotide construct

<400>  46
atggctctgc ctgtgacggc cctgcttttg cccctcgccc tgcttctgca tgccgcgaga       60

cccgacgtgt tgatgaccca aataccgctt agtctgcctg tatctcttgg ggaccaggct      120

agcatctcat gccgcagcag tcaatccatt gtgcactcaa atgggaacac ctatttggag      180

tggtatctgc aaaaaccggg acagtctccg aaactgctga tatacaaagt aagcaacagg      240

ttcagcggag ttcctgacag attcagcgga agcggttctg gaactgactt tacacttaag      300

atctctcgcg ttgaggcgga ggacctgggc gtgtattact gttttcaagg atcccacgtc      360

ccgtttacat tcggatcagg caccaagctg gagatcaagc gcggtggcgg gggttctggc      420

gggggcggat ccggaggcgg cggatcccag gtgcagctgc agcagtctgg accagaactg      480

gttaagcccg gagcttcagt taagatttcc tgtaaggctt caggctatac attttccact      540

tcttggatga actgggtgaa acagcgccct ggccaggggc tggaatggat cggacggatc      600

tatcccggcg atggagacac taattataac ggtaagttca aagggaaggc caccctcacg      660

gccgacaagt cctccaatac agcgtacatg caactcagtt ccctgaccag cgttgatagc      720

gcagtttact tctgtgagcg cttctattac ggaaacacct tcgctatgga ttactggggt      780

caggggacct ccgtgaccgt gtcctctacc acaacacctg ctccaaggcc ccccacaccc      840

gctccaacta tagccagcca accattgagc ctcagacctg aagcttgcag gcccgcagca      900

ggaggcgccg tccatacgcg aggcctggac ttcgcgtgtg atatttatat ttgggcccct      960

ttggccggaa catgtggggt gttgcttctc tcccttgtga tcactctgta ttgtaagcgc     1020

gggagaaaga agctcctgta catcttcaag cagcctttta tgcgacctgt gcaaaccact     1080

caggaagaag atgggtgttc atgccgcttc cccgaggagg aagaaggagg gtgtgaactg     1140

agggtgaaat tttctagaag cgccgatgct cccgcatatc agcagggtca gaatcagctc     1200

tacaatgaat tgaatctcgg caggcgagaa gagtacgatg ttctggacaa gagacggggc     1260

agggatcccg agatgggggg aaagccccgg agaaaaaatc ctcaggaggg gttgtacaat     1320

gagctgcaga aggacaagat ggctgaagcc tatagcgaga tcggaatgaa aggcgaaaga     1380

cgcagaggca aggggcatga cggtctgtac cagggtctct ctacagccac caaggacact     1440

tatgatgcgt tgcatatgca agccttgcca ccccgcgggt ccggtgaggg acgaggatct     1500

ctgttaacgt gtggcgatgt cgaggaaaat cctggcccaa tggcgctccc tgtcacagca     1560

ctgctccttc cgctggctct gcttctgcac gctgctaggc cagaagttca actccagcag     1620

agcggcgcag agctcgtgaa gcccggagct tcagtgaaga tgtcatgtaa agcctcagga     1680

tatactttta cttcatacaa tatgcactgg gtgaagcaga caccgggtca gggacttgag     1740

tggatcggcg caatataccc cggaaatgga gacaccagct acaaccagaa atttaaggga     1800

aaagccaccc tgacagccga taaatcctcc agtacggctt acatgcaatt gagctcactg     1860

actagcgagg actccgcaga ttattattgt gctagaagta actactacgg cagctcctat     1920

tggttttttg acgtgtgggg ggcgggcacc accgttacag tcagcagtgg cggcggaggt     1980

tcaggtgggg ggggctctgg aggcggtggg tctgatatcg tcttgactca aagcccagcg     2040

atattgtcag cctcccctgg agagaaagtg actatgacct gcagggctag cagctctgtt     2100

aattatatgg attggtatca gaagaaacct ggcagctccc ctaagccctg gatttatgct     2160

acatcaaatc tcgcctcagg ggtgccagcc aggttcagtg gatccggcag tggcaccagc     2220

tatagcctga caatctcaag ggtcgaagca gaggacgccg caacatatta ttgtcagcaa     2280

tggagcttta atccccccac atttggcgga ggaaccaagt tggagatcaa gaccacgacc     2340

ccggcacccc ggccacctac accagcccct acaattgcta gccagcccct gagccttagg     2400

ccagaagcct gtagacccgc cgccggcggt gcggttcaca cccggggact cgacttcgcc     2460

tgtgatatat atatctgggc acccctggcc ggcacatgtg gagtgcttct gctgtccttg     2520

gtcattaccc tctactgcaa acgcggtcgg aagaagcttc tgtacatctt caaacaaccc     2580

ttcatgaggc ctgtgcagac aacacaggag gaggatggct gtagttgcag attccctgaa     2640

gaagaggaag gtggctgcga gctccgggtt aaattttcta ggagcgccga cgcgccagca     2700

taccagcagg gccagaacca gctctacaac gagctcaacc tggggcgcag ggaggagtat     2760

gacgtgcttg acaagaggag aggccgggat ccagagatgg gcgggaagcc taggcggaaa     2820

aacccacagg aggggttgta caacgagctt caaaaggaca aaatggccga agcctactct     2880

gaaataggca tgaagggcga acgcagacga ggcaaaggcc acgacggact gtatcaagga     2940

ttgtctaccg ctacaaagga tacctacgac gcactgcata tgcaggccct gcctcctagg     3000

taa                                                                   3003


<210>  47
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR-T2A-anti-CD20 BBz CAR 
       construct

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Ala Phe Ser Phe Ser Trp Met Asn Trp Val Lys Trp Gly Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asn Gly Asp Thr Asn 
65                  70                  75                  80  


Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Arg Trp Val Tyr Ser Gly Asn Asn Tyr Ala 
        115                 120                 125             


Val Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Arg Ser Asp Val Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
                245                 250                 255     


Pro Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
                485                 490                 495     


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
        515                 520                 525             


Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala 
    530                 535                 540                 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
545                 550                 555                 560 


Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro 
                565                 570                 575     


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
            580                 585                 590         


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
        595                 600                 605             


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
    610                 615                 620                 


Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
625                 630                 635                 640 


Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
        675                 680                 685             


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
    690                 695                 700                 


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
705                 710                 715                 720 


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                725                 730                 735     


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
            740                 745                 750         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
        755                 760                 765             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        835                 840                 845             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    850                 855                 860                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
865                 870                 875                 880 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                885                 890                 895     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            900                 905                 910         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        915                 920                 925             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    930                 935                 940                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
945                 950                 955                 960 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                965                 970                 975     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            980                 985                 990         


Leu His Met Gln Ala Leu Pro Pro  Arg 
        995                 1000     


<210>  48
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79A-10_HL CAR-T2A-anti-CD20 BBz CAR 
       polynucleotide construct

<400>  48
atggctctgc cagtgactgc gctgctgctg cccctcgctc ttctgctgca cgccgctcgg       60

ccacaggtcc aactgcaaca gagcggcccc gagctggtaa aacccggggc ctccgtaaaa      120

atatcctgca agaccagcgg ctatgccttt tcattctcct ggatgaactg ggtgaagtgg      180

ggacccggtc agggacttga gtggatcggg cgaatctatc ccggaaacgg ggacacgaat      240

tacaacggca aatttaaagg caaggctact ctgactgctg acaaaagtag caacaccgcc      300

tacatgcagt tgtcctcttt gacatcagta gactctgcag tgtatttttg cgcccggtgg      360

gtttactccg gaaataacta cgcggttgac tattggggac agggcacctc cgtgacagtg      420

tcttctggcg gcgggggatc aggtggcggc gggtctgggg gtggaaggag cgacgtggtt      480

atgacccaga cccctttgag cctgcccgtg agccttggcg accaagcctc catctcttgc      540

cggtcctctc aatcactggt gcacagtaac gggaatactt atctccactg gtatttgcaa      600

aagcccggtc agtctcctaa gcttctgatc tataaggtgt ccaaccgctt ttctggagtg      660

cccgatagat tttccggatc tggatccggg acagacttca cattgaagat tagtagagtc      720

gaagcggagg acttgggtgt ttatttttgt tcccagagta cccacgtgcc tccatacacg      780

tttggaggtg gaaccaaact tgaaattaag accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgcg ggtccggtga gggacgagga     1500

tctctgttaa cgtgtggcga tgtcgaggaa aatcctggcc caatggcgct ccctgtcaca     1560

gcactgctcc ttccgctggc tctgcttctg cacgctgcta ggccagaagt tcaactccag     1620

cagagcggcg cagagctcgt gaagcccgga gcttcagtga agatgtcatg taaagcctca     1680

ggatatactt ttacttcata caatatgcac tgggtgaagc agacaccggg tcagggactt     1740

gagtggatcg gcgcaatata ccccggaaat ggagacacca gctacaacca gaaatttaag     1800

ggaaaagcca ccctgacagc cgataaatcc tccagtacgg cttacatgca attgagctca     1860

ctgactagcg aggactccgc agattattat tgtgctagaa gtaactacta cggcagctcc     1920

tattggtttt ttgacgtgtg gggggcgggc accaccgtta cagtcagcag tggcggcgga     1980

ggttcaggtg gggggggctc tggaggcggt gggtctgata tcgtcttgac tcaaagccca     2040

gcgatattgt cagcctcccc tggagagaaa gtgactatga cctgcagggc tagcagctct     2100

gttaattata tggattggta tcagaagaaa cctggcagct cccctaagcc ctggatttat     2160

gctacatcaa atctcgcctc aggggtgcca gccaggttca gtggatccgg cagtggcacc     2220

agctatagcc tgacaatctc aagggtcgaa gcagaggacg ccgcaacata ttattgtcag     2280

caatggagct ttaatccccc cacatttggc ggaggaacca agttggagat caagaccacg     2340

accccggcac cccggccacc tacaccagcc cctacaattg ctagccagcc cctgagcctt     2400

aggccagaag cctgtagacc cgccgccggc ggtgcggttc acacccgggg actcgacttc     2460

gcctgtgata tatatatctg ggcacccctg gccggcacat gtggagtgct tctgctgtcc     2520

ttggtcatta ccctctactg caaacgcggt cggaagaagc ttctgtacat cttcaaacaa     2580

cccttcatga ggcctgtgca gacaacacag gaggaggatg gctgtagttg cagattccct     2640

gaagaagagg aaggtggctg cgagctccgg gttaaatttt ctaggagcgc cgacgcgcca     2700

gcataccagc agggccagaa ccagctctac aacgagctca acctggggcg cagggaggag     2760

tatgacgtgc ttgacaagag gagaggccgg gatccagaga tgggcgggaa gcctaggcgg     2820

aaaaacccac aggaggggtt gtacaacgag cttcaaaagg acaaaatggc cgaagcctac     2880

tctgaaatag gcatgaaggg cgaacgcaga cgaggcaaag gccacgacgg actgtatcaa     2940

ggattgtcta ccgctacaaa ggatacctac gacgcactgc atatgcaggc cctgcctcct     3000

aggtaa                                                                3006


<210>  49
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - PDCD-1 I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  49

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Thr Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Gly Leu Ser Ile Leu Asn Arg 
            20                  25                  30          


Asn Arg Gly Thr Ala Arg Tyr His Thr Arg Leu Ser Phe Thr Ile Met 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Ser Ile Leu Asn Asn Gly Asp His Tyr Val Ser Leu Val 
65                  70                  75                  80  


Val Tyr Ala Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Val Ile Ser Arg Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Gly Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Phe Val Arg Leu Arg Lys Ser Asn Val Asn Ala 
            180                 185                 190         


Arg Val Arg Val Gln Leu Val Phe Glu Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly His Ile 
    210                 215                 220                 


Tyr Glu Gly Asn Lys Ser Glu Arg Ser Trp Leu Gln Phe Arg Val Glu 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Met Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Arg Arg Xaa Xaa 
    290                 295                 300             


<210>  50
<211>  944
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - PDCD-1 megaTAL construct

<400>  50

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
545                 550                 555                 560 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala 
            580                 585                 590         


Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro 
        595                 600                 605             


Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile 
    610                 615                 620                 


Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala 
625                 630                 635                 640 


Ile Ser Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp 
                645                 650                 655     


Thr Leu Thr Gly Phe Ala Asp Ala Glu Gly Ser Phe Gly Leu Ser Ile 
            660                 665                 670         


Leu Asn Arg Asn Arg Gly Thr Ala Arg Tyr His Thr Arg Leu Ser Phe 
        675                 680                 685             


Thr Ile Met Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln 
    690                 695                 700                 


Ser Thr Trp Lys Val Gly Ser Ile Leu Asn Asn Gly Asp His Tyr Val 
705                 710                 715                 720 


Ser Leu Val Val Tyr Ala Phe Glu Asp Leu Lys Val Ile Ile Asp His 
                725                 730                 735     


Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu 
            740                 745                 750         


Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu 
        755                 760                 765             


Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly 
    770                 775                 780                 


Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu Val Ile Ser Arg Glu 
785                 790                 795                 800 


Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Gly Lys Trp Leu Ala Gly 
                805                 810                 815     


Phe Thr Ser Gly Asp Gly Ser Phe Phe Val Arg Leu Arg Lys Ser Asn 
            820                 825                 830         


Val Asn Ala Arg Val Arg Val Gln Leu Val Phe Glu Ile Ser Gln His 
        835                 840                 845             


Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys 
    850                 855                 860                 


Gly His Ile Tyr Glu Gly Asn Lys Ser Glu Arg Ser Trp Leu Gln Phe 
865                 870                 875                 880 


Arg Val Glu Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe 
                885                 890                 895     


Gln Glu Asn Thr Leu Ile Gly Met Lys Leu Glu Asp Phe Glu Asp Trp 
            900                 905                 910         


Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser 
        915                 920                 925             


Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Arg Arg 
    930                 935                 940                 


<210>  51
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  51
ggcatgcaga tcccacaggc gc                                                22


<210>  52
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  52
ggtggggctg ctccaggcat gcagatccca caggcgc                                37


<210>  53
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CBLB I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(306)
<223>  Xaa is any amino acid or absent

<400>  53

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn Ala 
            20                  25                  30          


Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile Val 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu Gln 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Ser Phe Val Val Glu Leu Lys Lys Arg Arg Ser Pro Val 
            180                 185                 190         


Lys Val Gly Val Arg Leu Arg Phe Ser Ile Thr Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg Ile 
    210                 215                 220                 


Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa 
305     


<210>  54
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CBLB megaTAL construct

<400>  54

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu 
    610                 615                 620                 


Thr Gly Phe Ala Asp Ala Glu Gly Cys Phe Arg Leu Asp Ile Arg Asn 
625                 630                 635                 640 


Ala Asn Asp Leu Arg Ala Gly Tyr Arg Thr Arg Leu Ala Phe Glu Ile 
                645                 650                 655     


Val Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr 
            660                 665                 670         


Trp Lys Val Gly Thr Ile Tyr Asn Ala Gly Asp Asn Ala Val Arg Leu 
        675                 680                 685             


Gln Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu 
    690                 695                 700                 


Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys 
705                 710                 715                 720 


Gln Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly 
                725                 730                 735     


Ile Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn 
            740                 745                 750         


Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser 
        755                 760                 765             


Leu Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr 
    770                 775                 780                 


Ser Gly Asp Gly Ser Phe Val Val Glu Leu Lys Lys Arg Arg Ser Pro 
785                 790                 795                 800 


Val Lys Val Gly Val Arg Leu Arg Phe Ser Ile Thr Gln His Ile Arg 
                805                 810                 815     


Asp Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Arg 
            820                 825                 830         


Ile Val Glu Asn Asn Lys Ser Glu His Ser Trp Leu Glu Phe Ile Val 
        835                 840                 845             


Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu 
    850                 855                 860                 


Asn Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys 
865                 870                 875                 880 


Val Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu 
                885                 890                 895     


Asp Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
            900                 905                 910         


Ser Gly Arg 
        915 


<210>  55
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  55
ctgtaagata ttcccatccc ca                                                22


<210>  56
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  56
ttgttatgag gtatggtctg taagatattc ccatcccca                              39


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  57

Asp Gly Gly Gly Ser 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  58

Thr Gly Glu Lys Pro 
1               5   


<210>  59
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  59

Gly Gly Arg Arg 
1               


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  60

Gly Gly Gly Gly Ser 
1               5   


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  61

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  62

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  63

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  64

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  65

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  66
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  66

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  67
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  67

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  68

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  69

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  70

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  71
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  71

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  72

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  73

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  74
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  74

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  75
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  75

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  76

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  77
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  77

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  78

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  79

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  80
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  80

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  81
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  81

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  82
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  82

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  83
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  83

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  84

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  85
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  85

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  86

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  87

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  88
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  88

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  89
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  89

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  90
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  90

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  91
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  91

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  92

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  93
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  93
gccrccatgg                                                              10


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining heavy chain CDR-H1motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa is any amino acid

<400>  94

Cys Xaa Xaa Xaa 
1               


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining heavy chain CDR-H2 motif

<400>  95

Leu Glu Trp Ile Gly 
1               5   


<210>  96
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining heavy chain CDR-H3 motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<400>  96

Trp Gly Xaa Gly 
1               

<210>  97
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining light chain CDR-L3 motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<400>  97

Phe Gly Xaa Gly 
1   
