                         SEQUENCE LISTING

<110>  SANFORD HEALTH
       INANOVATE, INC.
       EGLAND, Kristi
       EVANS, Rick
       THIRUPPATHI, Eagappanath
       URE, David
       KOTSURA, Matt
       GNIMPIEBA, Etienne
 
<120>  Reagents and Methods for Cancer Detection, Prognosis, and 
       Therapeutic Monitoring

<130>  17-689-PCT

<150>  US 62/859,264
<151>  2019-06-10

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Pro Arg Arg Arg Ser Arg Lys Pro Glu Ala Pro Arg Arg Arg 
1               5                   10                  15      


Ser Pro Ser Pro Thr Pro Thr Pro Gly Pro Ser Arg Arg Gly Pro Ser 
            20                  25                  30          


Leu Gly Ala Ser Ser His Gln His Ser Arg Arg Arg Gln Gly Trp Leu 
        35                  40                  45              


Lys Glu Ile Arg Lys Leu Gln Lys Ser Thr His Leu Leu Ile Arg Lys 
    50                  55                  60                  


Leu Pro Phe Ser Arg Leu Ala Arg Glu Ile Cys Val Lys Phe Thr Arg 
65                  70                  75                  80  


Gly Val Asp Phe Asn Trp Gln Ala Gln Ala Leu Leu Ala Leu Gln Glu 
                85                  90                  95      


Ala Ala Glu Ala Phe Leu Val His Leu Phe Glu Asp Ala Tyr Leu Leu 
            100                 105                 110         


Thr Leu His Ala Gly Arg Val Thr Leu Phe Pro Lys Asp Val Gln Leu 
        115                 120                 125             


Ala Arg Arg Ile Arg Gly Leu Glu Glu Gly Leu Gly 
    130                 135                 140 


<210>  2
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  3
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
1               5                   10                  15      


Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
            20                  25                  30          


His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
        35                  40                  45              


Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
    50                  55                  60                  


Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
65                  70                  75                  80  


Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                85                  90                  95      


Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
            100                 105                 110         


Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
        115                 120                 125             


Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
    130                 135                 140                 


Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
145                 150                 155                 160 


Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                165                 170                 175     


Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
            180                 185                 190         


Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
        195                 200                 205             


Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
    210                 215                 220                 


Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
225                 230                 235                 240 


Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                245                 250                 255     


Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
            260                 265                 270         


Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
        275                 280                 285             


Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
    290                 295                 300                 


Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
305                 310                 315                 320 


Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                325                 330                 335     


Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
            340                 345                 350         


Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
        355                 360                 365             


Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
    370                 375                 380                 


Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
385                 390                 395                 400 


Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                405                 410                 415     


Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
            420                 425                 430         


Glu Ala Ala Pro Glu 
        435         


<210>  4
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Val Pro Glu Thr Arg Pro Asn His Thr Ile Tyr Ile Asn Asn 
1               5                   10                  15      


Leu Asn Glu Lys Ile Lys Lys Asp Glu Leu Lys Lys Ser Leu Tyr Ala 
            20                  25                  30          


Ile Phe Ser Gln Phe Gly Gln Ile Leu Asp Ile Leu Val Ser Arg Ser 
        35                  40                  45              


Leu Lys Met Arg Gly Gln Ala Phe Val Ile Phe Lys Glu Val Ser Ser 
    50                  55                  60                  


Ala Thr Asn Ala Leu Arg Ser Met Gln Gly Phe Pro Phe Tyr Asp Lys 
65                  70                  75                  80  


Pro Met Arg Ile Gln Tyr Ala Lys Thr Asp Ser Asp Ile Ile Ala Lys 
                85                  90                  95      


Met Lys Gly Thr Phe Val Glu Arg Asp Arg Lys Arg Glu Lys Arg Lys 
            100                 105                 110         


Pro Lys Ser Gln Glu Thr Pro Ala Thr Lys Lys Ala Val Gln Gly Gly 
        115                 120                 125             


Gly Ala Thr Pro Val Val Gly Ala Val Gln Gly Pro Val Pro Gly Met 
    130                 135                 140                 


Pro Pro Met Thr Gln Ala Pro Arg Ile Met His His Met Pro Gly Gln 
145                 150                 155                 160 


Pro Pro Tyr Met Pro Pro Pro Gly Met Ile Pro Pro Pro Gly Leu Ala 
                165                 170                 175     


Pro Gly Gln Ile Pro Pro Gly Ala Met Pro Pro Gln Gln Leu Met Pro 
            180                 185                 190         


Gly Gln Met Pro Pro Ala Gln Pro Leu Ser Glu Asn Pro Pro Asn His 
        195                 200                 205             


Ile Leu Phe Leu Thr Asn Leu Pro Glu Glu Thr Asn Glu Leu Met Leu 
    210                 215                 220                 


Ser Met Leu Phe Asn Gln Phe Pro Gly Phe Lys Glu Val Arg Leu Val 
225                 230                 235                 240 


Pro Gly Arg His Asp Ile Ala Phe Val Glu Phe Asp Asn Glu Val Gln 
                245                 250                 255     


Ala Gly Ala Ala Arg Asp Ala Leu Gln Gly Phe Lys Ile Thr Gln Asn 
            260                 265                 270         


Asn Ala Met Lys Ile Ser Phe Ala Lys Lys 
        275                 280         


<210>  5
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Lys Phe Tyr Cys Asp Tyr Cys Asp Thr Tyr Leu Thr His Asp 
1               5                   10                  15      


Ser Pro Ser Val Arg Lys Thr His Cys Ser Gly Arg Lys His Lys Glu 
            20                  25                  30          


Asn Val Lys Asp Tyr Tyr Gln Lys Trp Met Glu Glu Gln Ala Gln Ser 
        35                  40                  45              


Leu Ile Asp Lys Thr Thr Ala Ala Phe Gln Gln Gly Lys Ile Pro Pro 
    50                  55                  60                  


Thr Pro Phe Ser Ala Pro Pro Pro Ala Gly Ala Met Ile Pro Pro Pro 
65                  70                  75                  80  


Pro Ser Leu Pro Gly Pro Pro Arg Pro Gly Met Met Pro Ala Pro His 
                85                  90                  95      


Met Gly Gly Pro Pro Met Met Pro Met Met Gly Pro Pro Pro Pro Gly 
            100                 105                 110         


Met Met Pro Val Gly Pro Ala Pro Gly Met Arg Pro Pro Met Gly Gly 
        115                 120                 125             


His Met Pro Met Met Pro Gly Pro Pro Met Met Arg Pro Pro Ala Arg 
    130                 135                 140                 


Pro Met Met Val Pro Thr Arg Pro Gly Met Thr Arg Pro Asp Arg 
145                 150                 155                 


<210>  6
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Gly Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe 
1               5                   10                  15      


Arg Leu Asn Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu 
            20                  25                  30          


His Arg His Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys 
        35                  40                  45              


His Ser Asn Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys 
    50                  55                  60                  


Glu Lys Thr Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys 
65                  70                  75                  80  


His Lys Asp Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala 
                85                  90                  95      


Ser Gly Asp Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser 
            100                 105                 110         


Pro Pro Gln Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro 
        115                 120                 125             


Pro Lys Glu Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp 
    130                 135                 140                 


Ala Asp Tyr Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu 
145                 150                 155                 160 


Lys Lys Arg Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro 
                165                 170                 175     


Lys Asn Lys Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys 
            180                 185                 190         


Lys Lys Pro Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu 
        195                 200                 205             


Glu Arg Tyr Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly 
    210                 215                 220                 


Pro Val Phe Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe 
225                 230                 235                 240 


Tyr Tyr Asp Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val 
                245                 250                 255     


Ala Thr Phe Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu 
            260                 265                 270         


Ile Phe Arg Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn 
        275                 280                 285             


Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln 
    290                 295                 300                 


Met Ser Gln Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser 
305                 310                 315                 320 


Lys Glu Glu Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys 
                325                 330                 335     


Glu Tyr Gly Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn 
            340                 345                 350         


Phe Lys Ile Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro 
        355                 360                 365             


Lys Met Gly Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile 
    370                 375                 380                 


Asn Cys Ser Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys 
385                 390                 395                 400 


Trp Lys Glu Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp 
                405                 410                 415     


Thr Glu Asn Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser 
            420                 425                 430         


Ser Arg Ile Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Lys Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp 
    450                 455                 460                 


Trp Lys Ser Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr 
465                 470                 475                 480 


Phe Ile Asp Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly 
                485                 490                 495     


Glu Thr Ala Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile 
            500                 505                 510         


Asn Leu His Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp 
        515                 520                 525             


Phe Leu Gly Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu 
    530                 535                 540                 


Lys Arg Val Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro 
545                 550                 555                 560 


Glu Asp Asp Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His 
                565                 570                 575     


Leu Gln Asp Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr 
            580                 585                 590         


Asn Ala Ser Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro 
        595                 600                 605             


Asp Glu Asn Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg 
    610                 615                 620                 


Ala Val Ala Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe 
625                 630                 635                 640 


Glu Lys Ser Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu 
                645                 650                 655     


Gln Leu Ala Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala 
            660                 665                 670         


Lys Val Met Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys 
        675                 680                 685             


Lys Ala Val Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln 
    690                 695                 700                 


Ala Thr Asp Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys 
705                 710                 715                 720 


Leu Asn Tyr Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp 
                725                 730                 735     


Gly Val Pro Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe 
            740                 745                 750         


Ala Trp Ala Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe 
        755                 760                 765 


<210>  7
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
1               5                   10                  15      


Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
            20                  25                  30          


Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
        35                  40                  45              


Arg Lys Ile Lys Pro Lys Asn Ser Lys Gln Ala Glu Arg Glu Glu Lys 
    50                  55                  60                  


Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
65                  70                  75                  80  


Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                85                  90                  95      


Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly Arg 
            100                 105                 110         


Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu Ala 
        115                 120                 125             


Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
    130                 135                 140                 


Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro 
                165                 170                 175     


Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro Pro 
            180                 185                 190         


Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro Gly 
        195                 200                 205             


Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
    210                 215                 220                 


Pro Gly Met Arg Gly Leu Leu 
225                 230     


<210>  8
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
1               5                   10                  15      


Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
            20                  25                  30          


Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
        35                  40                  45              


Arg Lys Ile Lys Pro Lys Asn Ser Lys Gln Ala Glu Arg Glu Glu Lys 
    50                  55                  60                  


Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
65                  70                  75                  80  


Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                85                  90                  95      


Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly Arg 
            100                 105                 110         


Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu Ala 
        115                 120                 125             


Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
    130                 135                 140                 


Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro 
                165                 170                 175     


Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro Pro 
            180                 185                 190         


Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro Gly 
        195                 200                 205             


Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
    210                 215                 220                 


Pro Gly Met Arg Gly Pro Pro Pro Pro Gly Met Arg Pro Pro Arg Pro 
225                 230                 235                 240 


<210>  9
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr 
1               5                   10                  15      


Ile Glu Leu Lys Asn Gly Thr Gln Val His Gly Thr Ile Thr Gly Val 
            20                  25                  30          


Asp Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys 
        35                  40                  45              


Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser Ile Arg Gly Asn Asn 
    50                  55                  60                  


Ile Arg Tyr Phe Ile Leu Pro Asp Ser Leu Pro Leu Asp Thr Leu Leu 
65                  70                  75                  80  


Val Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala 
                85                  90                  95      


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Arg Gly Gly Pro Arg Arg 
        115                 


<210>  10
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Tyr Arg Gly Gln Gly Gln Lys Val Gln Lys Val Met Val Gln 
1               5                   10                  15      


Pro Ile Asn Leu Ile Phe Arg Tyr Leu Gln Asn Arg Ser Arg Ile Gln 
            20                  25                  30          


Val Trp Leu Tyr Glu Gln Val Asn Met Arg Ile Glu Gly Cys Ile Ile 
        35                  40                  45              


Gly Phe Asp Glu Tyr Met Asn Leu Val Leu Asp Asp Ala Glu Glu Ile 
    50                  55                  60                  


His Ser Lys Thr Lys Ser Arg Lys Gln Leu Gly Arg Ile Met Leu Lys 
65                  70                  75                  80  


Gly Asp Asn Ile Thr Leu Leu Gln Ser Val Ser Asn 
                85                  90          


<210>  11
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Leu Pro Leu Asn Pro Lys Pro Phe Leu Asn Gly Leu Thr Gly 
1               5                   10                  15      


Lys Pro Val Met Val Lys Leu Lys Trp Gly Met Glu Tyr Lys Gly Tyr 
            20                  25                  30          


Leu Val Ser Val Asp Gly Tyr Met Asn Met Gln Leu Ala Asn Thr Glu 
        35                  40                  45              


Glu Tyr Ile Asp Gly Ala Leu Ser Gly His Leu Gly Glu Val Leu Ile 
    50                  55                  60                  


Arg Cys Asn Asn Val Leu Tyr Ile Arg Gly Val Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Gly Glu Met Arg Glu 
                85      


<210>  12
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Lys Ala His Pro Pro Glu Leu Lys Lys Phe Met Asp Lys Lys 
1               5                   10                  15      


Leu Ser Leu Lys Leu Asn Gly Gly Arg His Val Gln Gly Ile Leu Arg 
            20                  25                  30          


Gly Phe Asp Pro Phe Met Asn Leu Val Ile Asp Glu Cys Val Glu Met 
        35                  40                  45              


Ala Thr Ser Gly Gln Gln Asn Asn Ile Gly Met Val Val Ile Arg Gly 
    50                  55                  60                  


Asn Ser Ile Ile Met Leu Glu Ala Leu Glu Arg Val 
65                  70                  75      


<210>  13
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly 
            20                  25                  30          


His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly 
        35                  40                  45              


Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg 
    50                  55                  60                  


Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly 
                85                  90                  95      


Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp 
            100                 105                 110         


Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu 
        115                 120                 125             


Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly 
    130                 135                 140                 


Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile 
145                 150                 155                 160 


Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser 
                165                 170                 175     


Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu 
            180                 185                 190         


Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu 
        195                 200                 205             


Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala 
    210                 215                 220                 


Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser 
                245                 250                 255     


Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val 
            260                 265                 270         


Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His 
        275                 280                 285             


Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly 
305                 310                 315                 320 


Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His 
                325                 330                 335     


Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu 
            340                 345                 350         


Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His 
        355                 360                 365             


Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn 
    370                 375                 380                 


Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu 
385                 390                 395                 400 


Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly 
                405                 410                 415     


Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser 
            420                 425                 430         


Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro 
        435                 440                 445             


Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro 
    450                 455                 460                 


Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr 
465                 470                 475 


<210>  14
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
1               5                   10                  15      


Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
            20                  25                  30          


Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
        35                  40                  45              


Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
    50                  55                  60                  


Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
65                  70                  75                  80  


Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                85                  90                  95      


Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
            100                 105                 110         


Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
        115                 120                 125             


Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
    130                 135                 140                 


Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
145                 150                 155                 160 


Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                165                 170                 175     


Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
            180                 185                 190         


Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
        195                 200                 205             


Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
    210                 215                 220                 


Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
225                 230                 235                 240 


Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                245                 250                 255     


Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
            260                 265                 270         


Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
        275                 280                 285             


Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
    290                 295                 300                 


Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
305                 310                 315                 320 


Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                325                 330                 335     


Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
            340                 345                 350         


Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
        355                 360                 365             


Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
385                 390                 395                 400 


Thr Glu Asn Gly Ala Gly Asp Gln 
                405             


<210>  15
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Pro Lys Arg Arg Gln Leu Thr Phe Arg Glu Lys Ser Arg Ile 
1               5                   10                  15      


Ile Gln Glu Val Glu Glu Asn Pro Asp Leu Arg Lys Gly Glu Ile Ala 
            20                  25                  30          


Arg Arg Phe Asn Ile Pro Pro Ser Thr Leu Ser Thr Ile Leu Lys Asn 
        35                  40                  45              


Lys Arg Ala Ile Leu Ala Ser Glu Arg Lys Tyr Gly Val Ala Ser Thr 
    50                  55                  60                  


Cys Arg Lys Thr Asn Lys Leu Ser Pro Tyr Asp Lys Leu Glu Gly Leu 
65                  70                  75                  80  


Leu Ile Ala Trp Phe Gln Gln Ile Arg Ala Ala Gly Leu Pro Val Lys 
                85                  90                  95      


Gly Ile Ile Leu Lys Glu Lys Ala Leu Arg Ile Ala Glu Glu Leu Gly 
            100                 105                 110         


Met Asp Asp Phe Thr Ala Ser Asn Gly Trp Leu Asp Arg Phe Arg Arg 
        115                 120                 125             


Arg His Gly Val Val Ser Cys Ser Gly Val Ala Arg Ala Arg Ala Arg 
    130                 135                 140                 


Asn Ala Ala Pro Arg Thr Pro Ala Ala Pro Ala Ser Pro Ala Ala Val 
145                 150                 155                 160 


Pro Ser Glu Gly Ser Gly Gly Ser Thr Thr Gly Trp Arg Ala Arg Glu 
                165                 170                 175     


Glu Gln Pro Pro Ser Val Ala Glu Gly Tyr Ala Ser Gln Asp Val Phe 
            180                 185                 190         


Ser Ala Thr Glu Thr Ser Leu Trp Tyr Asp Phe Leu Pro Asp Gln Ala 
        195                 200                 205             


Ala Gly Leu Cys Gly Gly Asp Gly Arg Pro Arg Gln Ala Thr Gln Arg 
    210                 215                 220                 


Leu Ser Val Leu Leu Cys Ala Asn Ala Asp Gly Ser Glu Lys Leu Pro 
225                 230                 235                 240 


Pro Leu Val Ala Gly Lys Ser Ala Lys Pro Arg Ala Gly Gln Ala Gly 
                245                 250                 255     


Leu Pro Cys Asp Tyr Thr Ala Asn Ser Lys Gly Gly Val Thr Thr Gln 
            260                 265                 270         


Ala Leu Ala Lys Tyr Leu Lys Ala Leu Asp Thr Arg Met Ala Ala Glu 
        275                 280                 285             


Ser Arg Arg Val Leu Leu Leu Ala Gly Arg Leu Ala Ala Gln Ser Leu 
    290                 295                 300                 


Asp Thr Ser Gly Leu Arg His Val Gln Leu Ala Phe Phe Pro Pro Gly 
305                 310                 315                 320 


Thr Val His Pro Leu Glu Arg Gly Val Val Gln Gln Val Lys Gly His 
                325                 330                 335     


Tyr Arg Gln Ala Met Leu Leu Lys Ala Met Ala Ala Leu Glu Gly Gln 
            340                 345                 350         


Asp Pro Ser Gly Leu Gln Leu Gly Leu Thr Glu Ala Leu His Phe Val 
        355                 360                 365             


Ala Ala Ala Trp Gln Ala Val Glu Pro Ser Asp Ile Ala Ala Cys Phe 
    370                 375                 380                 


Arg Glu Ala Gly Phe Gly Gly Gly Pro Asn Ala Thr Ile Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Ser Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Glu Gly Glu Glu Leu Gly Glu Glu Glu Glu Val 
        435                 440                 445             


Glu Glu Glu Gly Asp Val Asp Ser Asp Glu Glu Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Ser Ser Ser Glu Gly Leu Glu Ala Glu Asp Trp Ala Gln Gly Val 
465                 470                 475                 480 


Val Glu Ala Gly Gly Ser Phe Gly Ala Tyr Gly Ala Gln Glu Glu Ala 
                485                 490                 495     


Gln Cys Pro Thr Leu His Phe Leu Glu Gly Gly Glu Asp Ser Asp Ser 
            500                 505                 510         


Asp Ser Glu Glu Glu Asp Asp Glu Glu Glu Asp Asp Glu Asp Glu Asp 
        515                 520                 525             


Asp Asp Asp Asp Glu Glu Asp Gly Asp Glu Val Pro Val Pro Ser Phe 
    530                 535                 540                 


Gly Glu Ala Met Ala Tyr Phe Ala Met Val Lys Arg Tyr Leu Thr Ser 
545                 550                 555                 560 


Phe Pro Ile Asp Asp Arg Val Gln Ser His Ile Leu His Leu Glu His 
                565                 570                 575     


Asp Leu Val His Val Thr Arg Lys Asn His Ala Arg Gln Ala Gly Val 
            580                 585                 590         


Arg Gly Leu Gly His Gln Ser 
        595                 


<210>  16
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Pro Pro Ser Thr Arg Glu Pro Arg Val Leu Ser Ala Thr Ser 
1               5                   10                  15      


Ala Thr Lys Ser Asp Gly Glu Met Val Leu Pro Gly Phe Pro Asp Ala 
            20                  25                  30          


Asp Ser Phe Val Lys Phe Ala Leu Gly Ser Val Val Ala Val Thr Lys 
        35                  40                  45              


Ala Ser Gly Gly Leu Pro Gln Phe Gly Asp Glu Tyr Asp Phe Tyr Arg 
    50                  55                  60                  


Ser Phe Pro Gly Phe Gln Ala Phe Cys Glu Thr Gln Gly Asp Arg Leu 
65                  70                  75                  80  


Leu Gln Cys Met Ser Arg Val Met Gln Tyr His Gly Cys Arg Ser Asn 
                85                  90                  95      


Ile Lys Asp Arg Ser Lys Val Thr Glu Leu Glu Asp Lys Phe Asp Leu 
            100                 105                 110         


Leu Val Asp Ala Asn Asp Val Ile Leu Glu Arg Val Gly Ile Leu Leu 
        115                 120                 125             


Asp Glu Ala Ser Gly Val Asn Lys Asn Gln Gln Pro Val Leu Pro Ala 
    130                 135                 140                 


Gly Leu Gln Val Pro Lys Thr Val Val Ser Ser Trp Asn Arg Lys Ala 
145                 150                 155                 160 


Ala Glu Tyr Gly Lys Lys Ala Lys Ser Glu Thr Phe Arg Leu Leu His 
                165                 170                 175     


Ala Lys Asn Ile Ile Arg Pro Gln Leu Lys Phe Arg Glu Lys Ile Asp 
            180                 185                 190         


Asn Ser Asn Thr Pro Phe Leu Pro Lys Ile Phe Ile Lys Pro Asn Ala 
        195                 200                 205             


Gln Lys Pro Leu Pro Gln Ala Leu Ser Lys Glu Arg Arg Glu Arg Pro 
    210                 215                 220                 


Gln Asp Arg Pro Glu Asp Leu Asp Val Pro Pro Ala Leu Ala Asp Phe 
225                 230                 235                 240 


Ile His Gln Gln Arg Thr Gln Gln Val Glu Gln Asp Met Phe Ala His 
                245                 250                 255     


Pro Tyr Gln Tyr Glu Leu Asn His Phe Thr Pro Ala Asp Ala Val Leu 
            260                 265                 270         


Gln Lys Pro Gln Pro Gln Leu Tyr Arg Pro Ile Glu Glu Thr Pro Cys 
        275                 280                 285             


His Phe Ile Ser Ser Leu Asp Glu Leu Val Glu Leu Asn Glu Lys Leu 
    290                 295                 300                 


Leu Asn Cys Gln Glu Phe Ala Val Asp Leu Glu His His Ser Tyr Arg 
305                 310                 315                 320 


Ser Phe Leu Gly Leu Thr Cys Leu Met Gln Ile Ser Thr Arg Thr Glu 
                325                 330                 335     


Asp Phe Ile Ile Asp Thr Leu Glu Leu Arg Ser Asp Met Tyr Ile Leu 
            340                 345                 350         


Asn Glu Ser Leu Thr Asp Pro Ala Ile Val Lys Val Phe His Gly Ala 
        355                 360                 365             


Asp Ser Asp Ile Glu Trp Leu Gln Lys Asp Phe Gly Leu Tyr Val Val 
    370                 375                 380                 


Asn Met Phe Asp Thr His Gln Ala Ala Arg Leu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


His Ser Leu Asp His Leu Leu Lys Leu Tyr Cys Asn Val Asp Ser Asn 
                405                 410                 415     


Lys Gln Tyr Gln Leu Ala Asp Trp Arg Ile Arg Pro Leu Pro Glu Glu 
            420                 425                 430         


Met Leu Ser Tyr Ala Arg Asp Asp Thr His Tyr Leu Leu Tyr Ile Tyr 
        435                 440                 445             


Asp Lys Met Arg Leu Glu Met Trp Glu Arg Gly Asn Gly Gln Pro Val 
    450                 455                 460                 


Gln Leu Gln Val Val Trp Gln Arg Ser Arg Asp Ile Cys Leu Lys Lys 
465                 470                 475                 480 


Phe Ile Lys Pro Ile Phe Thr Asp Glu Ser Tyr Leu Glu Leu Tyr Arg 
                485                 490                 495     


Lys Gln Lys Lys His Leu Asn Thr Gln Gln Leu Thr Ala Phe Gln Leu 
            500                 505                 510         


Leu Phe Ala Trp Arg Asp Lys Thr Ala Arg Arg Glu Asp Glu Ser Tyr 
        515                 520                 525             


Gly Tyr Val Leu Pro Asn His Met Met Leu Lys Ile Ala Glu Glu Leu 
    530                 535                 540                 


Pro Lys Glu Pro Gln Gly Ile Ile Ala Cys Cys Asn Pro Val Pro Pro 
545                 550                 555                 560 


Leu Val Arg Gln Gln Ile Asn Glu Met His Leu Leu Ile Gln Gln Ala 
                565                 570                 575     


Arg Glu Met Pro Leu Leu Lys Ser Glu Val Ala Ala Gly Val Lys Lys 
            580                 585                 590         


Ser Gly Pro Leu Pro Ser Ala Glu Arg Leu Glu Asn Val Leu Phe Gly 
        595                 600                 605             


Pro His Asp Cys Ser His Ala Pro Pro Asp Gly Tyr Pro Ile Ile Pro 
    610                 615                 620                 


Thr Ser Gly Ser Val Pro Val Gln Lys Gln Ala Ser Leu Phe Pro Asp 
625                 630                 635                 640 


Glu Lys Glu Asp Asn Leu Leu Gly Thr Thr Cys Leu Ile Ala Thr Ala 
                645                 650                 655     


Val Ile Thr Leu Phe Asn Glu Pro Ser Ala Glu Asp Ser Lys Lys Gly 
            660                 665                 670         


Pro Leu Thr Val Ala Gln Lys Lys Ala Gln Asn Ile Met Glu Ser Phe 
        675                 680                 685             


Glu Asn Pro Phe Arg Met Phe Leu Pro Ser Leu Gly His Arg Ala Pro 
    690                 695                 700                 


Val Ser Gln Ala Ala Lys Phe Asp Pro Ser Thr Lys Ile Tyr Glu Ile 
705                 710                 715                 720 


Ser Asn Arg Trp Lys Leu Ala Gln Val Gln Val Gln Lys Asp Ser Lys 
                725                 730                 735     


Glu Ala Val Lys Lys Lys Ala Ala Glu Gln Thr Ala Ala Arg Glu Gln 
            740                 745                 750         


Ala Lys Glu Ala Cys Lys Ala Ala Ala Glu Gln Ala Ile Ser Val Arg 
        755                 760                 765             


Gln Gln Val Val Leu Glu Asn Ala Ala Lys Lys Arg Glu Arg Ala Thr 
    770                 775                 780                 


Ser Asp Pro Arg Thr Thr Glu Gln Lys Gln Glu Lys Lys Arg Leu Lys 
785                 790                 795                 800 


Ile Ser Lys Lys Pro Lys Asp Pro Glu Pro Pro Glu Lys Glu Phe Thr 
                805                 810                 815     


Pro Tyr Asp Tyr Ser Gln Ser Asp Phe Lys Ala Phe Ala Gly Asn Ser 
            820                 825                 830         


Lys Ser Lys Val Ser Ser Gln Phe Asp Pro Asn Lys Gln Thr Pro Ser 
        835                 840                 845             


Gly Lys Lys Cys Ile Ala Ala Lys Lys Ile Lys Gln Ser Val Gly Asn 
    850                 855                 860                 


Lys Ser Met Ser Phe Pro Thr Gly Lys Ser Asp Arg Gly Phe Arg Tyr 
865                 870                 875                 880 


Asn Trp Pro Gln Arg 
                885 


<210>  17
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile 
1               5                   10                  15      


Ala Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg 
            20                  25                  30          


Leu His Arg Phe Leu Cys Phe Gly Ser Glu Gly Gly Thr Tyr Tyr Ile 
        35                  40                  45              


Lys Glu Gln Lys Leu Gly Leu Glu Asn Ala Glu Ala Leu Ile Arg Leu 
    50                  55                  60                  


Ile Glu Asp Gly Arg Gly Cys Glu Val Ile Gln Glu Ile Lys Ser Phe 
65                  70                  75                  80  


Ser Gln Glu Gly Arg Thr Thr Lys Gln Glu Pro Met Leu Phe Ala Leu 
                85                  90                  95      


Ala Ile Cys Ser Gln Cys Ser Asp Ile Ser Thr Lys Gln Ala Ala Phe 
            100                 105                 110         


Lys Ala Val Ser Glu Val Cys Arg Ile Pro Thr His Leu Phe Thr Phe 
        115                 120                 125             


Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys Cys Gly Met Trp 
    130                 135                 140                 


Gly Arg Ala Leu Arg Lys Ala Ile Ala Asp Trp Tyr Asn Glu Lys Gly 
145                 150                 155                 160 


Gly Met Ala Leu Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly 
                165                 170                 175     


Trp Ser His Lys Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser 
            180                 185                 190         


Glu Gly Leu Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu 
        195                 200                 205             


Val His Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys 
    210                 215                 220                 


Leu Leu Lys Tyr Leu Glu Ala Val Glu Lys Val Lys Arg Thr Arg Asp 
225                 230                 235                 240 


Glu Leu Glu Val Ile His Leu Ile Glu Glu His Arg Leu Val Arg Glu 
                245                 250                 255     


His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu 
            260                 265                 270         


Leu Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met 
        275                 280                 285             


Thr Ala Asn Ser Val Leu Glu Pro Gly Asn Ser Glu Val Ser Leu Val 
    290                 295                 300                 


Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His 
305                 310                 315                 320 


Pro Phe His Ile Leu Ile Ala Leu Glu Thr Tyr Lys Thr Gly His Gly 
                325                 330                 335     


Leu Arg Gly Lys Leu Lys Trp Arg Pro Asp Glu Glu Ile Leu Lys Ala 
            340                 345                 350         


Leu Asp Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val Glu Pro Thr Gly 
        355                 360                 365             


Lys Arg Phe Leu Leu Ala Val Asp Val Ser Ala Ser Met Asn Gln Arg 
    370                 375                 380                 


Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met Cys 
385                 390                 395                 400 


Met Val Val Thr Arg Thr Glu Lys Asp Ser Tyr Val Val Ala Phe Ser 
                405                 410                 415     


Asp Glu Met Val Pro Cys Pro Val Thr Thr Asp Met Thr Leu Gln Gln 
            420                 425                 430         


Val Leu Met Ala Met Ser Gln Ile Pro Ala Gly Gly Thr Asp Cys Ser 
        435                 440                 445             


Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro Ala Asp Val Phe 
    450                 455                 460                 


Ile Val Phe Thr Asp Asn Glu Thr Phe Ala Gly Gly Val His Pro Ala 
465                 470                 475                 480 


Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys Leu 
                485                 490                 495     


Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp Pro Asp 
            500                 505                 510         


Asp Arg Ala Leu Gln Asn Thr Leu Leu Asn Lys Ser Phe 
        515                 520                 525 


<210>  18
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  19
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu Cys Met Asp Val 
1               5                   10                  15      


Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu 
            20                  25                  30          


Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala 
        35                  40                  45              


Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr 
    50                  55                  60                  


Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His 
65                  70                  75                  80  


Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser 
                85                  90                  95      


Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile 
            100                 105                 110         


Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu 
        115                 120                 125             


Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys 
    130                 135                 140                 


Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser 
145                 150                 155                 160 


Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu Asp Gly Ser Gly 
                165                 170                 175     


Asp Arg Gly Asp Gly Pro Phe Arg Leu Gly Gly His Gly Pro Ser Phe 
            180                 185                 190         


Pro Leu Lys Gly Ile Thr Glu Gln Gln Lys Glu Gly Leu Glu Ile Val 
        195                 200                 205             


Lys Met Val Met Ile Ser Leu Glu Gly Glu Asp Gly Leu Asp Glu Ile 
    210                 215                 220                 


Tyr Ser Phe Ser Glu Ser Leu Arg Lys Leu Cys Val Phe Lys Lys Ile 
225                 230                 235                 240 


Glu Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn 
                245                 250                 255     


Leu Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val 
            260                 265                 270         


Lys Lys Thr Trp Thr Val Val Asp Ala Lys Thr Leu Lys Lys Glu Asp 
        275                 280                 285             


Ile Gln Lys Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu 
    290                 295                 300                 


Val Leu Lys Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile 
305                 310                 315                 320 


Val Pro Phe Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu 
                325                 330                 335     


Gly Lys Cys Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln 
            340                 345                 350         


Arg Arg Phe Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg 
        355                 360                 365             


Asp Asp Glu Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu 
    370                 375                 380                 


Asp Asp Leu Asp Met Val Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg 
385                 390                 395                 400 


Ala Asn Pro Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr 
                405                 410                 415     


Glu Cys Leu Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln 
            420                 425                 430         


Tyr Met Phe Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu 
        435                 440                 445             


Ala Gln Leu Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala 
    450                 455                 460                 


Lys Lys Asp Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr 
465                 470                 475                 480 


Lys Ile Pro Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His 
                485                 490                 495     


Arg Ala Leu His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile 
            500                 505                 510         


Trp Asn Met Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile 
        515                 520                 525             


Pro Leu Ser Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys 
    530                 535                 540                 


Lys Asp Gln Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Ala Lys Lys Leu Lys Thr Glu Gln Gly Gly Ala His Phe 
                565                 570                 575     


Ser Val Ser Ser Leu Ala Glu Gly Ser Val Thr Ser Val Gly Ser Val 
            580                 585                 590         


Asn Pro Ala Glu Asn Phe Arg Val Leu Val Lys Gln Lys Lys Ala Ser 
        595                 600                 605             


Phe Glu Glu Ala Ser Asn Gln Leu Ile Asn His Ile Glu Gln Phe Leu 
    610                 615                 620                 


Asp Thr Asn Glu Thr Pro Tyr Phe Met Lys Ser Ile Asp Cys Ile Arg 
625                 630                 635                 640 


Ala Phe Arg Glu Glu Ala Ile Lys Phe Ser Glu Glu Gln Arg Phe Asn 
                645                 650                 655     


Asn Phe Leu Lys Ala Leu Gln Glu Lys Val Glu Ile Lys Gln Leu Asn 
            660                 665                 670         


His Phe Trp Glu Ile Val Val Gln Asp Gly Ile Thr Leu Ile Thr Lys 
        675                 680                 685             


Glu Glu Ala Ser Gly Ser Ser Val Thr Ala Glu Glu Ala Lys Lys Phe 
    690                 695                 700                 


Leu Ala Pro Lys Asp Lys Pro Ser Gly Asp Thr Ala Ala Val Phe Glu 
705                 710                 715                 720 


Glu Gly Gly Asp Val Asp Asp Leu Leu Asp Met Ile 
                725                 730         


<210>  20
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Glu Thr Pro Leu Ser Asn Cys Glu Arg Arg Phe Leu Leu Arg 
1               5                   10                  15      


Ala Ile Glu Glu Lys Lys Arg Leu Asp Gly Arg Gln Thr Tyr Asp Tyr 
            20                  25                  30          


Arg Asn Ile Arg Ile Ser Phe Gly Thr Asp Tyr Gly Cys Cys Ile Val 
        35                  40                  45              


Glu Leu Gly Lys Thr Arg Val Leu Gly Gln Val Ser Cys Glu Leu Val 
    50                  55                  60                  


Ser Pro Lys Leu Asn Arg Ala Thr Glu Gly Ile Leu Phe Phe Asn Leu 
65                  70                  75                  80  


Glu Leu Ser Gln Met Ala Ala Pro Ala Phe Glu Pro Gly Arg Gln Ser 
                85                  90                  95      


Asp Leu Leu Val Lys Leu Asn Arg Leu Met Glu Arg Cys Leu Arg Asn 
            100                 105                 110         


Ser Lys Cys Ile Asp Thr Glu Ser Leu Cys Val Val Ala Gly Glu Lys 
        115                 120                 125             


Val Trp Gln Ile Arg Val Asp Leu His Leu Leu Asn His Asp Gly Asn 
    130                 135                 140                 


Ile Ile Asp Ala Ala Ser Ile Ala Ala Ile Val Ala Leu Cys His Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Val Ser Val Gln Gly Asp Glu Val Thr Leu Tyr Thr 
                165                 170                 175     


Pro Glu Glu Arg Asp Pro Val Pro Leu Ser Ile His His Met Pro Ile 
            180                 185                 190         


Cys Val Ser Phe Ala Phe Phe Gln Gln Gly Thr Tyr Leu Leu Val Asp 
        195                 200                 205             


Pro Asn Glu Arg Glu Glu Arg Val Met Asp Gly Leu Leu Val Ile Ala 
    210                 215                 220                 


Met Asn Lys His Arg Glu Ile Cys Thr Ile Gln Ser Ser Gly Gly Ile 
225                 230                 235                 240 


Met Leu Leu Lys Asp Gln Val Leu Arg Cys Ser Lys Ile Ala Gly Val 
                245                 250                 255     


Lys Val Ala Glu Ile Thr Glu Leu Ile Leu Lys Ala Leu Glu Asn Asp 
            260                 265                 270         


Gln Lys Val Arg Lys Glu Gly Gly Lys Phe Gly Phe Ala Glu Ser Ile 
        275                 280                 285             


Ala Asn Gln Arg Ile Thr Ala Phe Lys Met Glu Lys Ala Pro Ile Asp 
    290                 295                 300                 


Thr Ser Asp Val Glu Glu Lys Ala Glu Glu Ile Ile Ala Glu Ala Glu 
305                 310                 315                 320 


Pro Pro Ser Glu Val Val Ser Thr Pro Val Leu Trp Thr Pro Gly Thr 
                325                 330                 335     


Ala Gln Ile Gly Glu Gly Val Glu Asn Ser Trp Gly Asp Leu Glu Asp 
            340                 345                 350         


Ser Glu Lys Glu Asp Asp Glu Gly Gly Gly Asp Gln Ala Ile Ile Leu 
        355                 360                 365             


Asp Gly Ile Lys Met Asp Thr Gly Val Glu Val Ser Asp Ile Gly Ser 
    370                 375                 380                 


Gln Glu Leu Gly Phe His His Val Gly Gln Thr Gly Leu Glu Phe Leu 
385                 390                 395                 400 


Thr Ser Asp Ala Pro Ile Ile Leu Ser Asp Ser Glu Glu Glu Glu Met 
                405                 410                 415     


Ile Ile Leu Glu Pro Asp Lys Asn Pro Lys Lys Ile Arg Thr Gln Thr 
            420                 425                 430         


Thr Ser Ala Lys Gln Glu Lys Ala Pro Ser Lys Lys Pro Val Lys Arg 
        435                 440                 445             


Arg Lys Lys Lys Arg Ala Ala Asn 
    450                 455     


<210>  21
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His 
1               5                   10                  15      


Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr 
            20                  25                  30          


Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser 
        35                  40                  45              


Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu 
    50                  55                  60                  


Ser Arg Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys 
65                  70                  75                  80  


Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln 
                85                  90                  95      


Gln Arg His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser 
            100                 105                 110         


Gln Phe Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys 
        115                 120                 125             


Pro Ala Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro 
    130                 135                 140                 


Ala His Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu 
145                 150                 155                 160 


Leu Phe Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro 
                165                 170                 175     


Gln Gly Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly 
            180                 185                 190         


Gly Trp Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn 
        195                 200                 205             


Arg Pro Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu 
    210                 215                 220                 


Phe Trp Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn 
225                 230                 235                 240 


Ser Arg Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu 
                245                 250                 255     


Leu Gln Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu 
            260                 265                 270         


Gln Leu Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro 
        275                 280                 285             


Pro Ser Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp 
    290                 295                 300                 


Leu Arg Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp 
305                 310                 315                 320 


Phe Gly Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser 
                325                 330                 335     


Ile Pro Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr 
            340                 345                 350         


Trp Arg Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln 
        355                 360                 365             


Pro Met Ala Ala Glu Ala Ala Ser 
    370                 375     


<210>  22
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn 
1               5                   10                  15      


Leu Pro Pro Pro Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val 
            20                  25                  30          


Ser Ala Ala Pro Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr 
        35                  40                  45              


Ile Asp Asn Tyr Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly 
    50                  55                  60                  


Thr Asp Glu Tyr Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val 
65                  70                  75                  80  


Gln Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His 
                85                  90                  95      


Ala Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser 
            100                 105                 110         


Ser Asp Gln Asn His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu 
        115                 120                 125             


Ser Phe Gly Asn Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr 
    130                 135                 140                 


Thr Leu Ser Ser Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val 
145                 150                 155                 160 


Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His 
                165                 170                 175     


Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys 
            180                 185                 190         


Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
        195                 200                 205             


Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His 
    210                 215                 220                 


Gln Ala Ser Asn Ser Ser Arg Leu His Thr Cys Gln Arg His 
225                 230                 235             


<210>  23
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Arg Leu Asp Cys Val Lys Ala Ser Asp Gln Cys Leu Lys Glu Gln 
1               5                   10                  15      


Ser Cys Ser Thr Lys Tyr Arg Thr Leu Arg Gln Cys Val Ala Gly Lys 
            20                  25                  30          


Glu Thr Asn Phe Ser Leu Ala Ser Gly Leu Glu Ala Lys Asp Glu Cys 
        35                  40                  45              


Arg Ser Ala Met Glu Ala Leu Lys Gln Lys Ser Leu Tyr Asn Cys Arg 
    50                  55                  60                  


Cys Lys Arg Gly Met Lys Lys Glu Lys Asn Cys Leu Arg Ile Tyr Trp 
65                  70                  75                  80  


Ser Met Tyr Gln Ser Leu Gln Gly Asn Asp Leu Leu Glu Asp Ser Pro 
                85                  90                  95      


Tyr Glu Pro Val Asn Ser Arg Leu Ser Asp Ile Phe Arg Val Val Pro 
            100                 105                 110         


Phe Ile Ser Asp Val Phe Gln Gln Val Glu His Ile Pro Lys Gly Asn 
        115                 120                 125             


Asn Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asp Asp Ile Cys Lys 
    130                 135                 140                 


Lys Tyr Arg Ser Ala Tyr Ile Thr Pro Cys Thr Thr Ser Val Ser Asn 
145                 150                 155                 160 


Asp Val Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
                165                 170                 175     


Asp Lys Val Pro Ala Lys His Ser Tyr Gly Met Leu Phe Cys Ser Cys 
            180                 185                 190         


Arg Asp Ile Ala Cys Thr Glu Arg Arg Arg Gln Thr Ile Val Pro Val 
        195                 200                 205             


Cys Ser Tyr Glu Glu Arg Glu Lys Pro Asn Cys Leu Asn Leu Gln Asp 
    210                 215                 220                 


Ser Cys Lys Thr Asn Tyr Ile Cys Arg Ser Arg Leu Ala Asp Phe Phe 
225                 230                 235                 240 


Thr Asn Cys Gln Pro Glu Ser Arg Ser Val Ser Ser Cys Leu Lys Glu 
                245                 250                 255     


Asn Tyr Ala Asp Cys Leu Leu Ala Tyr Ser Gly Leu Ile Gly Thr Val 
            260                 265                 270         


Met Thr Pro Asn Tyr Ile Asp Ser Ser Ser Leu Ser Val Ala Pro Trp 
        275                 280                 285             


Cys Asp Cys Ser Asn Ser Gly Asn Asp Leu Glu Glu Cys Leu Lys Phe 
    290                 295                 300                 


Leu Asn Phe Phe Lys Asp Asn Thr Cys Leu Lys Asn Ala Ile Gln Ala 
305                 310                 315                 320 


Phe Gly Asn Gly Ser Asp Val Thr Val Trp Gln Pro Ala Phe Pro Val 
                325                 330                 335     


Gln Thr Thr Thr Ala Thr Thr Thr Thr Ala Leu Arg Val Lys Asn Lys 
            340                 345                 350         


Pro Leu Gly Pro Ala Gly Ser Glu Asn Glu Ile Pro Thr His Val Leu 
        355                 360                 365             


Pro Pro Cys Ala Asn Leu Gln Ala Gln Lys Leu Lys Ser Asn Val Ser 
    370                 375                 380                 


Gly Asn Thr His Leu Cys Ile Ser Asn Gly Asn Tyr Glu Lys Glu Gly 
385                 390                 395                 400 


Leu Gly Ala Ser Ser His Ile Thr Thr Lys Ser Met Ala Ala Pro Pro 
                405                 410                 415     


Ser Cys Gly Leu Ser Pro Leu Leu Val Leu Val Val Thr Ala Leu Ser 
            420                 425                 430         


Thr Leu Leu Ser Leu Thr Glu Thr Ser 
        435                 440     


<210>  24
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu Asp 
1               5                   10                  15      


Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys Trp 
            20                  25                  30          


Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp Ala 
        35                  40                  45              


His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr Ser 
    50                  55                  60                  


Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His His 
65                  70                  75                  80  


Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys Phe 
                85                  90                  95      


Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp Ser 
            100                 105                 110         


Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp Gly 
        115                 120                 125             


Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg 
    130                 135                 140                 


Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr Arg 
145                 150                 155                 160 


Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro Ala 
                165                 170                 175     


Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys Pro 
            180                 185                 190         


Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu Pro 
        195                 200                 205             


Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys Ser 
    210                 215                 220                 


Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln 
225                 230                 235                 240 


Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys 
                245                 250                 255     


Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser 
            260                 265                 270         


Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly 
        275                 280                 285             


Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys 
    290                 295                 300                 


Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu Gln 
305                 310                 315                 320 


Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser 
                325                 330                 335     


Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val 
            340                 345                 350         


Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu 
        355                 360                 365             


Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His Gln 
    370                 375                 380                 


His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys Gln 
385                 390                 395                 400 


Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg Arg 
                405                 410                 415     


Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr Ser 
            420                 425                 430         


Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp Ala 
        435                 440                 445             


Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys 
    450                 455                 460                 


Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu Lys 
465                 470                 475                 480 


Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro His 
                485                 490                 495     


Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp 
            500                 505                 510         


Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro 
        515                 520                 525             


Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro Ala 
    530                 535                 540                 


Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu Ala 
545                 550                 555                 560 


Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu Leu 
                565                 570                 575     


<210>  25
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  25

His Pro Asp Arg Ile Ile Phe Pro Asn His Ala Cys Glu Asp Pro Pro 
1               5                   10                  15      


Ala Val Leu Leu Glu Val Gln Gly Thr Leu Gln Arg Pro Leu Val Arg 
            20                  25                  30          


Asp Ser Arg Thr Ser Pro Ala Asn Cys Thr Trp Leu Ile Leu Gly Ser 
        35                  40                  45              


Lys Glu Gln Thr Val Thr Ile Arg Phe Gln Lys Leu His Leu Ala Cys 
    50                  55                  60                  


Gly Ser Glu Arg Leu Thr Leu Arg Ser Pro Leu Gln Pro Leu Ile Ser 
65                  70                  75                  80  


Leu Cys Glu Ala Pro Pro Ser Pro Leu Gln Leu Pro Gly Gly Asn Val 
                85                  90                  95      


Thr Ile Thr Tyr Ser Tyr Ala Gly Ala Arg Ala Pro Met Gly Gln Gly 
            100                 105                 110         


Phe Leu Leu Ser Tyr Ser Gln Asp Trp Leu Met Cys Leu Gln Glu Glu 
        115                 120                 125             


Phe Gln Cys Leu Asn His Arg Cys Val Ser Ala Val Gln Arg Cys Asp 
    130                 135                 140                 


Gly Val Asp Ala Cys Gly Asp Gly Ser Asp Glu Ala Gly Cys Ser Ser 
145                 150                 155                 160 


Asp Pro Phe Pro Gly Leu Thr Pro Arg Pro Val Pro Ser Leu Pro Cys 
                165                 170                 175     


Asn Val Thr Leu Glu Asp Phe Tyr Gly Val Phe Ser Ser Pro Gly Tyr 
            180                 185                 190         


Thr His Leu Ala Ser Val Ser His Pro Gln Ser Cys His Trp Leu Leu 
        195                 200                 205             


Asp Pro His Asp Gly Arg Arg Leu Ala Val Arg Phe Thr Ala Leu Asp 
    210                 215                 220                 


Leu Gly Phe Gly Asp Ala Val His Val Tyr Asp Gly Pro Gly Pro Pro 
225                 230                 235                 240 


Glu Ser Ser Arg Leu Leu Arg Ser Leu Thr His Phe Ser Asn Gly Lys 
                245                 250                 255     


Ala Val Thr Val Glu Thr Leu Ser Gly Gln Ala Val Val Ser Tyr His 
            260                 265                 270         


Thr Val Ala Trp Ser Asn Gly Arg Gly Phe Asn Ala Thr Tyr His Val 
        275                 280                 285             


Arg Gly Tyr Cys Leu Pro Trp Asp Arg Pro Cys Gly Leu Gly Ser Gly 
    290                 295                 300                 


Leu Gly Ala Gly Glu Gly Leu Gly Glu Arg Cys Tyr Ser Glu Ala Gln 
305                 310                 315                 320 


Arg Cys Asp Gly Ser Trp Asp Cys Ala Asp Gly Thr Asp Glu Glu Asp 
                325                 330                 335     


Cys Pro Gly Cys Pro Pro Gly His Phe Pro Cys Gly Ala Ala Gly Thr 
            340                 345                 350         


Ser Gly Ala Thr Ala Cys Tyr Leu Pro Ala Asp Arg Cys Asn Tyr Gln 
        355                 360                 365             


Thr Phe Cys Ala Asp Gly Ala Asp Glu Arg Arg Cys Arg His Cys Gln 
    370                 375                 380                 


Pro Gly Asn Phe Arg Cys Arg Asp Glu Lys Cys Val Tyr Glu Thr Trp 
385                 390                 395                 400 


Val Cys Asp Gly Gln Pro Asp Cys Ala Asp Gly Ser Asp Glu Trp Asp 
                405                 410                 415     


Cys Ser Tyr Val Leu Pro Arg Lys 
            420                 


<210>  26
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  26

Trp Ser Pro Gln Glu Glu Asp Arg Ile Ile Glu Gly Gly Ile Tyr Asp 
1               5                   10                  15      


Ala Asp Leu Asn Asp Glu Arg Val Gln Arg Ala Leu His Phe Val Ile 
            20                  25                  30          


Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr Arg Arg Leu Leu 
        35                  40                  45              


Arg Val Leu Arg Ala Arg Glu Gln Ile Val Gly Gly Val Asn Tyr Phe 
    50                  55                  60                  


Phe Asp Ile Glu Val Gly Arg Thr Ile Cys Thr Lys Ser Gln Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu Gln Lys Lys Gln 
                85                  90                  95      


Leu Cys Ser Phe Gln Ile Tyr Glu Val Pro Trp Glu Asp Arg Met Ser 
            100                 105                 110         


Leu Val Asn Ser Arg Cys Gln Glu Ala 
        115                 120     


<210>  27
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  28
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val Leu 
1               5                   10                  15      


Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro Arg 
            20                  25                  30          


Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys Asp 
        35                  40                  45              


Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe Gln 
    50                  55                  60                  


Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn Leu 
65                  70                  75                  80  


Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg Leu 
                85                  90                  95      


Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys Ile 
            100                 105                 110         


Lys Cys Val Ala Phe Asp 
        115             


<210>  29
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Pro Lys Pro Ala Thr Val Val Thr Gly Ser Gly His Ala Ser Ser 
1               5                   10                  15      


Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val 
            20                  25                  30          


Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro 
        35                  40                  45              


Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe 
    50                  55                  60                  


Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys 
65                  70                  75                  80  


Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu 
                85                  90                  95      


Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
            100                 105                 110         


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
        115                 120                 125             


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
    130                 135                 140                 


Gly 
145 


<210>  30
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly Ile Asp 
1               5                   10                  15      


Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly Arg Val 
            20                  25                  30          


Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser Tyr Val 
        35                  40                  45              


Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn 
    50                  55                  60                  


Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys Arg Leu 
65                  70                  75                  80  


Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile Lys Phe 
                85                  90                  95      


Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile Gln Val 
            100                 105                 110         


Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu Ile Ser 
        115                 120                 125             


Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly 
    130                 135                 140                 


Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp 
145                 150                 155                 160 


Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn 
                165                 170                 175     


Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly 
            180                 185                 190         


Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp Leu Gly 
        195                 200                 205             


Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly Val Phe 
    210                 215                 220                 


Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe 
225                 230                 235                 240 


Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys Lys Thr 
                245                 250                 255     


Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu Arg Arg 
            260                 265                 270         


Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln Ala Arg 
        275                 280                 285             


Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu Thr Leu 
    290                 295                 300                 


Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg Ser Thr 
305                 310                 315                 320 


Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys Lys Ser 
                325                 330                 335     


Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys 
            340                 345                 350         


Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro Ser Arg 
        355                 360                 365             


Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala 
    370                 375                 380                 


Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu Leu Asp 
385                 390                 395                 400 


Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val Met Thr 
                405                 410                 415     


Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser Gln Ile 
            420                 425                 430         


Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys Val Tyr 
        435                 440                 445             


Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly Thr Phe 
    450                 455                 460                 


Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu 
465                 470                 475                 480 


Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr Ala Glu 
                485                 490                 495     


Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn Asp Gln 
            500                 505                 510         


Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp Ala Glu 
        515                 520                 525             


Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp Thr Arg 
    530                 535                 540                 


Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile Gly Asp 
545                 550                 555                 560 


Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu Thr Met 
                565                 570                 575     


Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His Gln Asp 
            580                 585                 590         


Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu Glu Ile 
        595                 600                 605             


Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro Pro Pro 
    610                 615                 620                 


Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
625                 630                 635     


<210>  31
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Glu Val Val Leu Leu Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly 
1               5                   10                  15      


Trp Leu Thr His Pro Tyr Gly Lys Gly Trp Asp Leu Met Gln Asn Ile 
            20                  25                  30          


Met Asn Asp Met Pro Ile Tyr Met Tyr Ser Val Cys Asn Val Met Ser 
        35                  40                  45              


Gly Asp Gln Asp Asn Trp Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu 
    50                  55                  60                  


Ala Glu Arg Ile Phe Ile Glu Leu Lys Phe Thr Val Arg Asp Cys Asn 
65                  70                  75                  80  


Ser Phe Pro Gly Gly Ala Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr 
                85                  90                  95      


Tyr Ala Glu Ser Asp Leu Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu 
            100                 105                 110         


Phe Thr Lys Ile Asp Thr Ile Ala Pro Asp Glu Ile Thr Val Ser Ser 
        115                 120                 125             


Asp Phe Glu Ala Arg His Val Lys Leu Asn Val Glu Glu Arg Ser Val 
    130                 135                 140                 


Gly Pro Leu Thr Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly 
145                 150                 155                 160 


Ala Cys Val Ala Leu Leu Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro 
                165                 170                 175     


Glu Leu Leu Gln Gly Leu Ala His Phe Pro Glu Thr Ile Ala Gly Ser 
            180                 185                 190         


Asp Ala Pro Ser Leu Ala Thr Val Ala Gly Thr Cys Val Asp His Ala 
        195                 200                 205             


Val Val Pro Pro Gly Gly Glu Glu Pro Arg Met His Cys Ala Val Asp 
    210                 215                 220                 


Gly Glu Trp Leu Val Pro Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr 
225                 230                 235                 240 


Glu Lys Val Glu Asp Ala Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys 
                245                 250                 255     


Phe Glu Ala Ser Glu Ser Pro Cys Leu Glu Cys Pro Glu His Thr Leu 
            260                 265                 270         


Pro Ser Pro Glu Gly Ala Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe 
        275                 280                 285             


Arg Ala Pro Gln Asp Pro Ala Ser Met Pro Cys Thr Arg Pro Pro Ser 
    290                 295                 300                 


Ala Pro His Tyr Leu Thr Ala Val Gly Met Gly Ala Lys Val Glu Leu 
305                 310                 315                 320 


Arg Trp Thr Pro Pro Gln Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr 
                325                 330                 335     


Ser Val Thr Cys Glu Gln Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro 
            340                 345                 350         


Cys Glu Ala Ser Val Arg Tyr Ser Glu Pro Pro His Gly Leu Thr Arg 
        355                 360                 365             


Thr Ser Val Thr Val Ser Asp Leu Glu Pro His Met Asn Tyr Thr Phe 
    370                 375                 380                 


Thr Val Glu Ala Arg Asn Gly Val Ser Gly Leu Val Thr Ser Arg Ser 
385                 390                 395                 400 


Phe Arg Thr Ala Ser Val Ser Ile Asn Gln Thr Glu Pro Pro Lys Val 
                405                 410                 415     


Arg Leu Glu Gly Arg Ser Thr Thr Ser Leu Ser Val Ser Trp Ser Ile 
            420                 425                 430         


Pro Pro Pro Gln Gln Ser Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg 
        435                 440                 445             


Lys Lys Gly Asp Ser Asn Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe 
    450                 455                 460                 


Ser Val Thr Leu Asp Asp Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln 
465                 470                 475                 480 


Val Gln Ala Leu Thr Gln Glu Gly Gln Gly Ala Gly Ser Lys Val His 
                485                 490                 495     


Glu Phe Gln Thr Leu Ser Pro Glu Gly Ser Gly Asn Leu 
            500                 505                 


<210>  32
<211>  1090
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly Lys Ser Arg Gln Cys 
1               5                   10                  15      


Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly Asn Gly Phe Arg Cys 
            20                  25                  30          


Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His Cys Glu Lys Cys Lys 
        35                  40                  45              


Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg Cys Leu Pro Cys Asn 
    50                  55                  60                  


Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys Asp Asn Ser Gly Arg 
65                  70                  75                  80  


Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg Cys Asp Arg Cys Leu 
                85                  90                  95      


Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys Thr Gln Asp Gln Arg 
            100                 105                 110         


Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala Gly Ile Ala Gly Pro 
        115                 120                 125             


Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala Val Thr Gly Glu Arg 
    130                 135                 140                 


Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu Asp Gly Gly Asn Pro 
145                 150                 155                 160 


Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His Ser Ala Ser Cys Arg 
                165                 170                 175     


Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr Ser Thr Phe His Gln 
            180                 185                 190         


Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn Gly Ser Pro Ala Lys 
        195                 200                 205             


Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe Ser Ser Ala Gln Arg 
    210                 215                 220                 


Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys Phe Leu Gly Asn Gln 
225                 230                 235                 240 


Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp Tyr Arg Val Asp Arg 
                245                 250                 255     


Gly Gly Arg His Pro Ser Ala His Asp Val Ile Leu Glu Gly Ala Gly 
            260                 265                 270         


Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly Lys Thr Leu Pro Cys 
        275                 280                 285             


Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn Glu His Pro Ser Asn 
    290                 295                 300                 


Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr Arg Arg Leu Leu Arg 
305                 310                 315                 320 


Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr Gly Glu Tyr Ser Thr 
                325                 330                 335     


Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala Arg Pro Val Ser Gly 
            340                 345                 350         


Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys Pro Val Gly Tyr Lys 
        355                 360                 365             


Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr Lys Arg Asp Ser Ala 
    370                 375                 380                 


Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys Asn Cys Gln Gly Gly 
385                 390                 395                 400 


Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr Ser Gly Asp Glu Asn 
                405                 410                 415     


Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly Phe Tyr Asn Asp Pro 
            420                 425                 430         


His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys His Asn Gly Phe Ser 
        435                 440                 445             


Cys Ser Val Met Pro Glu Thr Glu Glu Val Val Cys Asn Asn Cys Pro 
    450                 455                 460                 


Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys Ala Asp Gly Tyr Phe 
465                 470                 475                 480 


Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg Pro Cys Gln Pro Cys 
                485                 490                 495     


Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser Gly Asn Cys Asp Arg 
            500                 505                 510         


Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn Thr Ala Gly Ile Tyr 
        515                 520                 525             


Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp Pro Leu Ala Pro Asn 
    530                 535                 540                 


Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn Pro Met Gly Ser Glu 
545                 550                 555                 560 


Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val Cys Lys Pro Gly Phe 
                565                 570                 575     


Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser Cys Pro Ala Cys Tyr 
            580                 585                 590         


Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met Gln Gln Leu Gln Arg 
        595                 600                 605             


Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly Asp Gly Val Val Pro 
    610                 615                 620                 


Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala Glu Gln Ala Leu Gln 
625                 630                 635                 640 


Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly Ala Ser Arg Ser Leu 
                645                 650                 655     


Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu Asn Ser Tyr Gln Ser 
            660                 665                 670         


Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg Val Arg Ala Leu Gly 
        675                 680                 685             


Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His Arg Leu Ile Thr Gln 
    690                 695                 700                 


Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser Leu Gly Asn Thr Asn 
705                 710                 715                 720 


Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn Gly Phe Lys Ser Leu 
                725                 730                 735     


Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His Val Glu Ser Ala Ser 
            740                 745                 750         


Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp Tyr Ser Lys Gln Ala 
        755                 760                 765             


Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly Val Gly Ser Gly Ser 
    770                 775                 780                 


Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu Val Glu Lys Leu Glu 
785                 790                 795                 800 


Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg Glu Ala Thr Gln Ala 
                805                 810                 815     


Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser Leu Arg Leu Leu Asp 
            820                 825                 830         


Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln Ser Phe Gln Val Glu 
        835                 840                 845             


Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser Leu Ser Ser Leu Val 
    850                 855                 860                 


Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln Lys Asn Leu Gly Asn 
865                 870                 875                 880 


Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn Gly Lys Ser Gly Arg 
                885                 890                 895     


Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn Leu Ala Lys Ser Arg 
            900                 905                 910         


Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr Phe Tyr Glu Val Glu 
        915                 920                 925             


Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu Gln Val Asp Asn Arg 
    930                 935                 940                 


Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu Ser Tyr Ile Ser Gln 
945                 950                 955                 960 


Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln Ala Glu Arg Ala Leu 
                965                 970                 975     


Gly Ser Ala Ala Ala Asp Ala Gln Arg Ala Lys Asn Gly Ala Gly Glu 
            980                 985                 990         


Ala Leu Glu Ile Ser Ser Glu Ile  Glu Gln Glu Ile Gly  Ser Leu Asn 
        995                 1000                 1005             


Leu Glu  Ala Asn Val Thr Ala  Asp Gly Ala Leu Ala  Met Glu Lys 
    1010                 1015                 1020             


Gly Leu  Ala Ser Leu Lys Ser  Glu Met Arg Glu Val  Glu Gly Glu 
    1025                 1030                 1035             


Leu Glu  Arg Lys Glu Leu Glu  Phe Asp Thr Asn Met  Asp Ala Val 
    1040                 1045                 1050             


Gln Met  Val Ile Thr Glu Ala  Gln Lys Val Asp Thr  Arg Ala Lys 
    1055                 1060                 1065             


Asn Ala  Gly Val Thr Ile Gln  Asp Thr Leu Asn Thr  Leu Asp Gly 
    1070                 1075                 1080             


Leu Leu  His Leu Met Gly Met  
    1085                 1090 


<210>  33
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Pro Leu Gly Gly Glu Ser Ile Cys Ser Ala Arg Ala Pro Ala Lys 
1               5                   10                  15      


Tyr Ser Ile Thr Phe Thr Gly Lys Trp Ser Gln Thr Ala Phe Pro Lys 
            20                  25                  30          


Gln Tyr Pro Leu Phe Arg Pro Pro Ala Gln Trp Ser Ser Leu Leu Gly 
        35                  40                  45              


Ala Ala His Ser Ser Asp Tyr Ser Met Trp Arg Lys Asn Gln Tyr Val 
    50                  55                  60                  


Ser Asn Gly Leu Arg Asp Phe Ala Glu Arg Gly Glu Ala Trp Ala Leu 
65                  70                  75                  80  


Met Lys Glu Ile Glu Ala Ala Gly Glu Ala Leu Gln Ser Val His Glu 
                85                  90                  95      


Val Phe Ser Ala Pro Ala Val Pro Ser Gly Thr Gly Gln Thr Ser Ala 
            100                 105                 110         


Glu Leu Glu Val Gln Arg Arg His Ser Leu Val Ser Phe Val Val Arg 
        115                 120                 125             


Ile Val Pro Ser Pro Asp Trp Phe Val Gly Val Asp Ser Leu Asp Leu 
    130                 135                 140                 


Cys Asp Gly Asp Arg Trp Arg Glu Gln Ala Ala Leu Asp Leu Tyr Pro 
145                 150                 155                 160 


Tyr Asp Ala Gly Thr Asp Ser Gly Phe Thr Phe Ser Ser Pro Asn Phe 
                165                 170                 175     


Ala Thr Ile Pro Gln Asp Thr Val Thr Glu Ile Thr Ser Ser Ser Pro 
            180                 185                 190         


Ser His Pro Ala Asn Ser Phe Tyr Tyr Pro Arg Leu Lys Ala Leu Pro 
        195                 200                 205             


Pro Ile Ala Arg Val Thr Leu Leu Arg Leu Arg Gln Ser Pro Arg Ala 
    210                 215                 220                 


Phe Ile Pro Pro Ala Pro Val Leu Pro Ser Arg Asp Asn Glu Ile Val 
225                 230                 235                 240 


Asp Ser Ala Ser Val Pro Glu Thr Pro Leu Asp Cys Glu Val Ser Leu 
                245                 250                 255     


Trp Ser Ser Trp Gly Leu Cys Gly Gly His Cys Gly Arg Leu Gly Thr 
            260                 265                 270         


Lys Ser Arg Thr Arg Tyr Val Arg Val Gln Pro Ala Asn Asn Gly Ser 
        275                 280                 285             


Pro Cys Pro Glu Leu Glu Glu Glu Ala Glu Cys Val Pro Asp Asn Cys 
    290                 295                 300                 


Val 
305 


<210>  34
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Glu Gly Ala Arg Leu Leu Ala Ser Lys Ser Leu Leu Asn Arg Tyr 
1               5                   10                  15      


Ala Val Glu Gly Arg Asp Leu Thr Leu Gln Tyr Asn Ile Tyr Asn Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Leu Asp Val Glu Leu Ser Asp Asp Ser Phe Pro 
        35                  40                  45              


Pro Glu Asp Phe Gly Ile Val Ser Gly Met Leu Asn Val Lys Trp Asp 
    50                  55                  60                  


Arg Ile Ala Pro Ala Ser Asn Val Ser His Thr Val Val Leu Arg Pro 
65                  70                  75                  80  


Leu Lys Ala Gly Tyr Phe Asn Phe Thr Ser Ala Thr Ile Thr Tyr Leu 
                85                  90                  95      


Ala Gln Glu Asp Gly Pro Val Val Ile Gly Ser Thr Ser Ala Pro Gly 
            100                 105                 110         


Gln Gly Gly Ile Leu Ala Gln Arg Glu Phe Asp Arg Arg Phe Ser Pro 
        115                 120                 125             


His 
    


<210>  35
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser Arg Ala Ser Gln Val 
1               5                   10                  15      


Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro Thr Pro Leu Pro Trp 
            20                  25                  30          


Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His Ile Thr Glu Leu Asn 
        35                  40                  45              


Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile Ala Leu Arg Ile Glu 
    50                  55                  60                  


Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala Phe Arg Asn Leu Gly 
65                  70                  75                  80  


Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys Leu Gln Val Leu Pro 
                85                  90                  95      


Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu Ser Leu Leu Leu Ser 
            100                 105                 110         


Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His Phe Ser Gln Cys Ser 
        115                 120                 125             


Asn Leu Lys Glu Leu Gln Leu His Gly Asn His Leu Glu Tyr Ile Pro 
    130                 135                 140                 


Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr Lys Leu Asn Leu Gly 
145                 150                 155                 160 


Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val Phe Gln His Leu Gly 
                165                 170                 175     


Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg Leu Thr Asp Ile Pro 
            180                 185                 190         


Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln Glu Leu Ala Leu Gln 
        195                 200                 205             


Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu Phe His Asn Asn His 
    210                 215                 220                 


Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His Ile Ser Gln Leu Pro 
225                 230                 235                 240 


Pro Ser Val Phe Met Gln Leu Pro Gln Leu Asn Arg Leu Thr Leu Phe 
                245                 250                 255     


Gly Asn Ser Leu Lys Glu Leu Ser Pro Gly Ile Phe Gly Pro Met Pro 
            260                 265                 270         


Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His Ile Ser Ser Leu Pro 
        275                 280                 285             


Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln Val Leu Ile Leu Ser 
    290                 295                 300                 


Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala Phe Asn Gly Leu Thr 
305                 310                 315                 320 


Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala Leu Gln Asp Leu Asp 
                325                 330                 335     


Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln Asn Ile Ser Leu Gln 
            340                 345                 350         


Asn Asn Arg Leu Arg Gln Leu Pro Gly Asn Ile Phe Ala Asn Val Asn 
        355                 360                 365             


Gly Leu Met Ala Ile Gln Leu Gln Asn Asn Gln Leu Glu Asn Leu Pro 
    370                 375                 380                 


Leu Gly Ile Phe Asp His Leu Gly Lys Leu Cys Glu Leu Arg Leu Tyr 
385                 390                 395                 400 


Asp Asn Pro Trp Arg Cys Asp Ser Asp Ile Leu Pro Leu Arg Asn Trp 
                405                 410                 415     


Leu Leu Leu Asn Gln Pro Arg Leu Gly Thr Asp Thr Val Pro Val Cys 
            420                 425                 430         


Phe Ser Pro Ala Asn Val Arg Gly Gln Ser Leu Ile Ile Ile Asn Val 
        435                 440                 445             


Asn Val Ala Val Pro Ser Val His Val Pro Glu Val Pro Ser Tyr Pro 
    450                 455                 460                 


Glu Thr Pro Trp Tyr Pro Asp Thr Pro Ser Tyr Pro Asp Thr Thr Ser 
465                 470                 475                 480 


Val Ser Ser Thr Thr Glu Leu Thr Ser Pro Val Glu Asp Tyr Thr Asp 
                485                 490                 495     


Leu Thr Thr Ile Gln Val Thr Asp Asp Arg Ser Val Trp Gly Met Thr 
            500                 505                 510         


Gln Ala Gln Ser Gly 
        515         


<210>  36
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Pro Lys Pro Ala Thr Val Val Thr Gly Ser Gly His Ala Ser Ser 
1               5                   10                  15      


Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val 
            20                  25                  30          


Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro 
        35                  40                  45              


Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe 
    50                  55                  60                  


Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys 
65                  70                  75                  80  


Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu 
                85                  90                  95      


Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
            100                 105                 110         


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
        115                 120                 125             


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
    130                 135                 140                 


Gly 
145 


<210>  37
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp Leu Gly Ser Lys Ile 
1               5                   10                  15      


Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr Glu Val Thr Gly His 
            20                  25                  30          


Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu Asp Ala Leu Pro Gly 
        35                  40                  45              


Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp Gln Trp Gly Glu Tyr 
    50                  55                  60                  


Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr Ala Asn Ile Gln Leu 
65                  70                  75                  80  


His Gly Pro Pro Arg Val Lys Ala Val Lys Ser Ser Glu His Ile Asn 
                85                  90                  95      


Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser Glu Ser Val Pro Pro 
            100                 105                 110         


Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp Ser Glu Asp Lys Ala 
        115                 120                 125             


Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val Ser Ser 
    130                 135                 140     


<210>  38
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Gly Pro Ser Ser Gly Ser Cys Pro Pro Thr Lys Phe Gln Cys Arg 
1               5                   10                  15      


Thr Ser Gly Leu Cys Val Pro Leu Thr Trp Arg Cys Asp Arg Asp Leu 
            20                  25                  30          


Asp Cys Ser Asp Gly Ser Asp Glu Glu Glu Cys Arg Ile Glu Pro Cys 
        35                  40                  45              


Thr Gln Lys Gly Gln Cys Pro Pro Pro Pro Gly Leu Pro Cys Pro Cys 
    50                  55                  60                  


Thr Gly Val Ser Asp Cys Ser Gly Gly Thr Asp Lys Lys Leu Arg Asn 
65                  70                  75                  80  


Cys Ser Arg Leu Ala Cys Leu Ala Gly Glu Leu Arg Cys Thr Leu Ser 
                85                  90                  95      


Asp Asp Cys Ile Pro Leu Thr Trp Arg Cys Asp Gly His Pro Asp Cys 
            100                 105                 110         


Pro Asp Ser Ser Asp Glu Leu Gly Cys Gly Thr Asn Glu Ile Leu Pro 
        115                 120                 125             


Glu Gly Asp Ala Thr Thr Met Gly Pro Pro Val Thr Leu Glu Ser Val 
    130                 135                 140                 


Thr Ser Leu Arg Asn Ala Thr Thr Met Gly Pro Pro Val Thr Leu Glu 
145                 150                 155                 160 


Ser Val Pro Ser Val Gly Asn Ala Thr Ser Ser Ser Ala Gly Asp Gln 
                165                 170                 175     


Ser Gly Ser Pro Thr Ala Tyr Gly 
            180                 


<210>  39
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Pro Cys Arg Ala Val Phe Arg Glu Ala Glu Val Thr Leu Glu Ala 
1               5                   10                  15      


Gly Gly Ala Glu Gln Glu Pro Gly Gln Ala Leu Gly Lys Val Phe Met 
            20                  25                  30          


Gly Cys Pro Gly Gln Glu Pro Ala Leu Phe Ser Thr Asp Asn Asp Asp 
        35                  40                  45              


Phe Thr Val Arg Asn Gly Glu Thr Val Gln Glu Arg Arg Ser Leu Lys 
    50                  55                  60                  


Glu Arg Asn Pro Leu Lys Ile Phe Pro Ser Lys Arg Ile Leu Arg Arg 
65                  70                  75                  80  


His Lys Arg Asp Trp Val Val Ala Pro Ile Ser Val Pro Glu Asn Gly 
                85                  90                  95      


Lys Gly Pro Phe Pro Gln Arg Leu Asn Gln Leu Lys Ser Asn Lys Asp 
            100                 105                 110         


Arg Asp Thr Lys Ile Phe Tyr Ser Ile Thr Gly Pro Gly Ala Asp Ser 
        115                 120                 125             


Pro Pro Glu Gly Val Phe Ala Val Glu Lys Glu Thr Gly Trp Leu Leu 
    130                 135                 140                 


Leu Asn Lys Pro Leu Asp Arg Glu Glu Ile Ala Lys Tyr Glu Leu Phe 
145                 150                 155                 160 


Gly His Ala Val Ser Glu Asn Gly Ala Ser Val Glu Asp Pro Met Asn 
                165                 170                 175     


Ile Ser Ile Ile Val Thr Asp Gln Asn Asp His Lys Pro Lys Phe Thr 
            180                 185                 190         


Gln Asp Thr Phe Arg Gly Ser Val Leu Glu Gly Val Leu Pro Gly Thr 
        195                 200                 205             


Ser Val Met Gln Met Thr Ala Thr Asp Glu Asp Asp Ala Ile Tyr Thr 
    210                 215                 220                 


Tyr Asn Gly Val Val Ala Tyr Ser Ile His Ser Gln Glu Pro Lys Asp 
225                 230                 235                 240 


Pro His Asp Leu Met Phe Thr Ile His Arg Ser Thr Gly Thr Ile Ser 
                245                 250                 255     


Val Ile Ser Ser Gly Leu Asp Arg Glu Lys Val Pro Glu Tyr Thr Leu 
            260                 265                 270         


Thr Ile Gln Ala Thr Asp Met Asp Gly Asp Gly Ser Thr Thr Thr Ala 
        275                 280                 285             


Val Ala Val Val Glu Ile Leu Asp Ala Asn Asp Asn Ala Pro Met Phe 
    290                 295                 300                 


Asp Pro Gln Lys Tyr Glu Ala His Val Pro Glu Asn Ala Val Gly His 
305                 310                 315                 320 


Glu Val Gln Arg Leu Thr Val Thr Asp Leu Asp Ala Pro Asn Ser Pro 
                325                 330                 335     


Ala Trp Arg Ala Thr Tyr Leu Ile Met Gly Gly Asp Asp Gly Asp His 
            340                 345                 350         


Phe Thr Ile Thr Thr His Pro Glu Ser Asn Gln Gly Ile Leu Thr Thr 
        355                 360                 365             


Arg Lys Gly Leu Asp Phe Glu Ala Lys Asn Gln His Thr Leu Tyr Val 
    370                 375                 380                 


Glu Val Thr Asn Glu Ala Pro Phe Val Leu Lys Leu Pro Thr Ser Thr 
385                 390                 395                 400 


Ala Thr Ile Val Val His Val Glu Asp Val Asn Glu Ala Pro Val Phe 
                405                 410                 415     


Val Pro Pro Ser Lys Val Val Glu Val Gln Glu Gly Ile Pro Thr Gly 
            420                 425                 430         


Glu Pro Val Cys Val Tyr Thr Ala Glu Asp Pro Asp Lys Glu Asn Gln 
        435                 440                 445             


Lys Ile Ser Tyr Arg Ile Leu Arg Asp Pro Ala Gly Trp Leu Ala Met 
    450                 455                 460                 


Asp Pro Asp Ser Gly Gln Val Thr Ala Val Gly Thr Leu Asp Arg Glu 
465                 470                 475                 480 


Asp Glu Gln Phe Val Arg Asn Asn Ile Tyr Glu Val Met Val Leu Ala 
                485                 490                 495     


Met Asp Asn Gly Ser Pro Pro Thr Thr Gly Thr Gly Thr Leu Leu Leu 
            500                 505                 510         


Thr Leu Ile Asp Val Asn Asp His Gly Pro Val Pro Glu Pro Arg Gln 
        515                 520                 525             


Ile Thr Ile Cys Asn Gln Ser Pro Val Arg Gln Val Leu Asn Ile Thr 
    530                 535                 540                 


Asp Lys Asp Leu Ser Pro His Thr Ser Pro Phe Gln Ala Gln Leu Thr 
545                 550                 555                 560 


Asp Asp Ser Asp Ile Tyr Trp Thr Ala Glu Val Asn Glu Glu Gly Asp 
                565                 570                 575     


Thr Val Val Leu Ser Leu Lys Lys Phe Leu Lys Gln Asp Thr Tyr Asp 
            580                 585                 590         


Val His Leu Ser Leu Ser Asp His Gly Asn Lys Glu Gln Leu Thr Val 
        595                 600                 605             


Ile Arg Ala Thr Val Cys Asp Cys His Gly His Val Glu Thr Cys Pro 
    610                 615                 620                 


Gly Pro Trp Lys Gly Gly 
625                 630 


<210>  40
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  40

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr 
625                 630 


<210>  41
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  42
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Asp Arg Glu Arg Ser Ile His Asp Phe Cys Leu Val Ser Lys Val 
1               5                   10                  15      


Val Gly Arg Cys Arg Ala Ser Met Pro Arg Trp Trp Tyr Asn Val Thr 
            20                  25                  30          


Asp Gly Ser Cys Gln Leu Phe Val Tyr Gly Gly Cys Asp Gly Asn Ser 
        35                  40                  45              


Asn Asn Tyr Leu Thr Lys Glu Glu Cys Leu Lys Lys Cys Ala Thr Val 
    50                  55                  60                  


Thr Glu Asn Ala Thr Gly Asp Leu Ala Thr Ser Arg Asn Ala Ala Asp 
65                  70                  75                  80  


Ser Ser Val Pro Ser Ala Pro Arg Arg Gln Asp Ser Glu Asp His Ser 
                85                  90                  95      


Ser Asp Met Phe Asn Tyr Glu Glu Tyr Cys Thr Ala Asn Ala Val Thr 
            100                 105                 110         


Gly Pro Cys Arg Ala Ser Phe Pro Arg Trp Tyr Phe Asp Val Glu Arg 
        115                 120                 125             


Asn Ser Cys Asn Asn Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn 
    130                 135                 140                 


Ser Tyr Arg Ser Glu Glu Ala Cys Met Leu Arg Cys Phe Arg Gln Gln 
145                 150                 155                 160 


Glu Asn Pro Pro Leu Pro Leu Gly Ser Lys Val 
                165                 170     


<210>  43
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Glu Ser Cys Ser Met Arg Cys Gly Ala Leu Asp Gly Pro Cys Ser 
1               5                   10                  15      


Cys His Pro Thr Cys Ser Gly Leu Gly Thr Cys Cys Leu Asp Phe Arg 
            20                  25                  30          


Asp Phe Cys Leu Glu Ile Leu Pro Tyr Ser Gly Ser Met Met Gly Gly 
        35                  40                  45              


Lys Asp Phe Val Val Arg His Phe Lys Met Ser Ser Pro Thr Asp Ala 
    50                  55                  60                  


Ser Val Ile Cys Arg Phe Lys Asp Ser Ile Gln Thr Leu Gly His Val 
65                  70                  75                  80  


Asp Ser Ser Gly Gln Val His Cys Val Ser Pro Leu Leu Tyr Glu Ser 
                85                  90                  95      


Gly Arg Ile Pro Phe Thr Val Ser Leu Asp Asn Gly His Ser Phe Pro 
            100                 105                 110         


Arg Ala Gly Thr Trp Leu Ala Val His Pro Asn Lys Val Ser Met Met 
        115                 120                 125             


Glu Lys Ser Glu Leu Val Asn Glu Thr Arg Trp Gln Tyr Tyr Gly Thr 
    130                 135                 140                 


Ala Asn Thr Ser Gly Asn Leu Ser Leu Thr Trp His Val Lys Ser Leu 
145                 150                 155                 160 


Pro Thr Gln Thr Ile Thr Ile Glu Leu Trp Gly Tyr Glu Glu Thr Gly 
                165                 170                 175     


Met Pro Tyr Ser Gln Glu Trp Thr Ala Lys Trp Ser Tyr Leu Tyr Pro 
            180                 185                 190         


Leu Ala Thr His Ile Pro Asn Ser Gly Ser Phe Thr Phe Thr Pro Lys 
        195                 200                 205             


Pro Ala Pro Pro Ser Tyr Gln Arg Trp Arg Val Gly Ala Leu Arg Ile 
    210                 215                 220                 


Ile Asp Ser Lys Asn Tyr Ala Gly Gln Lys Asp Val Gln Ala Leu Trp 
225                 230                 235                 240 


Thr Asn Asp His Ala Leu Ala Trp His Leu Ser Asp Asp Phe Arg Glu 
                245                 250                 255     


Asp Pro Val Ala Trp Ala Arg Thr Gln Cys Gln Ala Trp Glu Glu Leu 
            260                 265                 270         


Glu Asp Gln Leu Pro Asn Phe Leu Glu Glu Leu Pro Asp Cys Pro Cys 
        275                 280                 285             


Thr Leu Thr Gln Ala Arg Ala Asp Ser Gly Arg Phe Phe Thr Asp Tyr 
    290                 295                 300                 


Gly Cys Asp Met Glu Gln Gly Ser Val Cys Thr Tyr His Pro Gly Ala 
305                 310                 315                 320 


Val His Cys Val Arg Ser Val Gln Ala Ser Leu Arg Tyr Gly Ser Gly 
                325                 330                 335     


Gln Gln Cys Cys Tyr Thr Ala Asp Gly Thr Gln Leu Leu Thr Ala Asp 
            340                 345                 350         


Ser Ser Gly Gly Ser Thr Pro Asp Arg Gly His Asp Trp Gly Ala Pro 
        355                 360                 365             


Pro Phe Arg Thr Pro Pro Arg Val Pro Ser Met Ser His Trp Leu Tyr 
    370                 375                 380                 


Asp Val Leu Ser Phe Tyr Tyr Cys Cys Leu Trp Ala Pro Asp Cys Pro 
385                 390                 395                 400 


Arg Tyr Met Gln Arg Arg Pro Ser Asn Asp Cys Arg Asn Tyr Arg Pro 
                405                 410                 415     


Pro Arg Leu Ala Ser Ala Phe Gly Asp Pro His Phe Val Thr Phe Asp 
            420                 425                 430         


Gly Thr Asn Phe Thr Phe Asn Gly Arg Gly Glu Tyr Val Leu Leu Glu 
        435                 440                 445             


Ala Ala Leu Thr Asp Leu Arg Val Gln Ala Arg Ala Gln Pro Gly Thr 
    450                 455                 460                 


Met Ser Asn Gly Thr Glu Thr Arg Gly Thr Gly Leu Thr Ala Val Ala 
465                 470                 475                 480 


Val Gln Glu Gly Asn Ser Asp Val Val Glu Val Arg Leu Ala Asn Arg 
                485                 490                 495     


Thr Gly Gly Leu Glu Val Leu Leu Asn Gln Glu Val Leu Ser Phe Thr 
            500                 505                 510         


Glu Gln Ser Trp Met Asp Leu Lys Gly Met Phe Leu Ser Val Ala Ala 
        515                 520                 525             


Gly Asp Arg Val Ser Ile Met Leu Ala Ser Gly Ala Gly Leu Glu Val 
    530                 535                 540                 


Ser Val Gln Gly Pro Phe Leu Ser Val Ser Val Leu Leu Pro Glu Lys 
545                 550                 555                 560 


Phe Leu Thr His Thr His Gly Leu Leu Gly Thr Leu Asn Asn Asp Pro 
                565                 570                 575     


Thr Asp Asp Phe Thr Leu His Ser Gly Arg Val Leu Pro Pro Gly Thr 
            580                 585                 590         


Ser Pro Gln Glu Leu Phe Leu Phe Gly Ala Asn Trp Thr Val His Asn 
        595                 600                 605             


Ala Ser Ser Leu Leu Thr Tyr Asp Ser Trp Phe Leu Val His Asn Phe 
    610                 615                 620                 


Leu Tyr Gln Pro Lys His Asp Pro Thr Phe Glu Pro Leu Phe Pro Ser 
625                 630                 635                 640 


Glu Thr Thr Leu Asn Pro Ser Leu Ala Gln Glu Ala Ala Lys Leu Cys 
                645                 650                 655     


Gly Asp Asp His Phe Cys Asn Phe Asp Val Ala Ala Thr Gly Ser Leu 
            660                 665                 670         


Ser Thr Gly Thr Ala Thr Arg Val Ala His Gln Leu His Gln Arg Arg 
        675                 680                 685             


Met Gln Ser Leu Gln Pro Val Val Ser Cys Gly Trp Leu Ala Pro Pro 
    690                 695                 700                 


Pro Asn Gly Gln Lys Glu Gly Asn Arg Tyr Leu Ala Gly Ser Thr Ile 
705                 710                 715                 720 


Tyr Phe His Cys Asp Asn Gly Tyr Ser Leu Ala Gly Ala Glu Thr Ser 
                725                 730                 735     


Thr Cys Gln Ala Asp Gly Thr Trp Ser Ser Pro Thr Pro Lys Cys Gln 
            740                 745                 750         


Pro Gly Arg Ser Tyr Ala 
        755             


<210>  44
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Gly Gly Ser Gly Ser His Gly Arg Arg Ser Leu Ala Ala Leu 
1               5                   10                  15      


Ser Gln Ile Ala Tyr Gln Arg Asn Asp Asp Asp Glu Glu Glu Ala Ala 
            20                  25                  30          


Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu Arg Leu Arg Gln Lys Gln 
        35                  40                  45              


Glu Glu Glu Ser Leu Gly Gln Val Thr Asp Gln Val Glu Val Asn Ala 
    50                  55                  60                  


Gln Asn Ser Val Pro Asp Glu Glu Ala Lys Thr Thr Thr Thr Asn Thr 
65                  70                  75                  80  


Gln Val Glu Gly Asp Asp Glu Ala Ala Phe Leu Glu Arg Leu Ala Arg 
                85                  90                  95      


Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln Glu Ala Leu Glu Arg Gln 
            100                 105                 110         


Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala Ser Leu Ser Leu Pro Ser 
        115                 120                 125             


Arg Arg Met Gln Asn Asp Thr Ala Glu Asn Glu Thr Thr Glu Lys Glu 
    130                 135                 140                 


Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr Glu Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp Trp Arg Asp Ala Glu Glu 
                165                 170                 175     


Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu Glu Glu Glu Glu Lys Pro 
            180                 185                 190         


Lys Arg Gly Ser Ile Gly Glu Asn Gln Gly Glu Glu Lys Gly Thr Lys 
        195                 200                 205             


Val Gln Ala Lys Arg Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys 
    210                 215                 220                 


Lys Glu Glu Ile Lys Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys 
225                 230                 235                 240 


Glu Glu Val Lys Ser Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val 
                245                 250                 255     


Lys Ser Gln Asn Gly Glu Phe Met Thr His Lys Leu Lys His Thr Glu 
            260                 265                 270         


Asn Thr Phe Ser Arg Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu 
        275                 280                 285             


Ala Glu Gly Ala Pro Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu 
    290                 295                 300                 


Arg Arg Arg Arg Gly Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys 
305                 310                 315                 320 


Gln Lys Gln Gln Glu Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys 
                325                 330                 335     


Arg Glu Glu Arg Arg Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys 
            340                 345                 350         


Gln Glu Glu Ala Asp Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg 
        355                 360                 365             


Leu Lys Glu Glu Ile Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg 
    370                 375                 380                 


Gln Lys Met Pro Glu Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys 
385                 390                 395                 400 


Cys Phe Thr Pro Lys Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu 
                405                 410                 415     


Phe Leu Asn Lys Ser Val Gln Lys Ser Ser Gly Val Lys Ser Thr His 
            420                 425                 430         


Gln Ala Ala Ile Val Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr 
        435                 440                 445             


Ser Ala Ile Glu Gly Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala 
    450                 455                 460                 


Ser Asp Leu Pro Val Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met 
465                 470                 475                 480 


Trp Glu Lys Gly Asn Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro 
                485                 490                 495     


Asn Lys Glu Thr Ala Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn 
            500                 505                 510         


Glu Trp Leu Thr Lys Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys 
        515                 520                 525             


Pro Ser Asp Leu Arg Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp 
    530                 535                 540                 


Glu Lys Gln Ser Val Asp Lys Val Thr Ser Pro Thr Lys Val 
545                 550                 555             


<210>  45
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
        35                  40                  45              


Gly Ile Asn Leu Asp Leu Gly Ser Gly Val Lys Val Lys Ile Ile Pro 
    50                  55                  60                  


Lys Glu Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln 
65                  70                  75                  80  


Val 
    


<210>  46
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  47
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


