                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  DEEP MUTATIONAL EVOLUTION OF BIOMOLECULES

<130>  SCRB-012/01WO 333322-2083

<140>  PCT/US2020/036506
<141>  2020-06-05

<150>  US 62/858,718
<151>  2016-06-07

<160>  4232  

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Unknown

<220>
<223>  Deltaproteobacteria sp.

<400>  1

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  2
<211>  978
<212>  PRT
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  2

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3
<211>  855
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  3

Met Asp Asn Ala Asn Lys Pro Ser Thr Lys Ser Leu Val Asn Thr Thr 
1               5                   10                  15      


Arg Ile Ser Asp His Phe Gly Val Thr Pro Gly Gln Val Thr Arg Val 
            20                  25                  30          


Phe Ser Phe Gly Ile Ile Pro Thr Lys Arg Gln Tyr Ala Ile Ile Glu 
        35                  40                  45              


Arg Trp Phe Ala Ala Val Glu Ala Ala Arg Glu Arg Leu Tyr Gly Met 
    50                  55                  60                  


Leu Tyr Ala His Phe Gln Glu Asn Pro Pro Ala Tyr Leu Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Tyr Glu Thr Phe Phe Lys Gly Arg Pro Val Leu Asn Gly Leu 
                85                  90                  95      


Arg Asp Ile Asp Pro Thr Ile Met Thr Ser Ala Val Phe Thr Ala Leu 
            100                 105                 110         


Arg His Lys Ala Glu Gly Ala Met Ala Ala Phe His Thr Asn His Arg 
        115                 120                 125             


Arg Leu Phe Glu Glu Ala Arg Lys Lys Met Arg Glu Tyr Ala Glu Cys 
    130                 135                 140                 


Leu Lys Ala Asn Glu Ala Leu Leu Arg Gly Ala Ala Asp Ile Asp Trp 
145                 150                 155                 160 


Asp Lys Ile Val Asn Ala Leu Arg Thr Arg Leu Asn Thr Cys Leu Ala 
                165                 170                 175     


Pro Glu Tyr Asp Ala Val Ile Ala Asp Phe Gly Ala Leu Cys Ala Phe 
            180                 185                 190         


Arg Ala Leu Ile Ala Glu Thr Asn Ala Leu Lys Gly Ala Tyr Asn His 
        195                 200                 205             


Ala Leu Asn Gln Met Leu Pro Ala Leu Val Lys Val Asp Glu Pro Glu 
    210                 215                 220                 


Glu Ala Glu Glu Ser Pro Arg Leu Arg Phe Phe Asn Gly Arg Ile Asn 
225                 230                 235                 240 


Asp Leu Pro Lys Phe Pro Val Ala Glu Arg Glu Thr Pro Pro Asp Thr 
                245                 250                 255     


Glu Thr Ile Ile Arg Gln Leu Glu Asp Met Ala Arg Val Ile Pro Asp 
            260                 265                 270         


Thr Ala Glu Ile Leu Gly Tyr Ile His Arg Ile Arg His Lys Ala Ala 
        275                 280                 285             


Arg Arg Lys Pro Gly Ser Ala Val Pro Leu Pro Gln Arg Val Ala Leu 
    290                 295                 300                 


Tyr Cys Ala Ile Arg Met Glu Arg Asn Pro Glu Glu Asp Pro Ser Thr 
305                 310                 315                 320 


Val Ala Gly His Phe Leu Gly Glu Ile Asp Arg Val Cys Glu Lys Arg 
                325                 330                 335     


Arg Gln Gly Leu Val Arg Thr Pro Phe Asp Ser Gln Ile Arg Ala Arg 
            340                 345                 350         


Tyr Met Asp Ile Ile Ser Phe Arg Ala Thr Leu Ala His Pro Asp Arg 
        355                 360                 365             


Trp Thr Glu Ile Gln Phe Leu Arg Ser Asn Ala Ala Ser Arg Arg Val 
    370                 375                 380                 


Arg Ala Glu Thr Ile Ser Ala Pro Phe Glu Gly Phe Ser Trp Thr Ser 
385                 390                 395                 400 


Asn Arg Thr Asn Pro Ala Pro Gln Tyr Gly Met Ala Leu Ala Lys Asp 
                405                 410                 415     


Ala Asn Ala Pro Ala Asp Ala Pro Glu Leu Cys Ile Cys Leu Ser Pro 
            420                 425                 430         


Ser Ser Ala Ala Phe Ser Val Arg Glu Lys Gly Gly Asp Leu Ile Tyr 
        435                 440                 445             


Met Arg Pro Thr Gly Gly Arg Arg Gly Lys Asp Asn Pro Gly Lys Glu 
    450                 455                 460                 


Ile Thr Trp Val Pro Gly Ser Phe Asp Glu Tyr Pro Ala Ser Gly Val 
465                 470                 475                 480 


Ala Leu Lys Leu Arg Leu Tyr Phe Gly Arg Ser Gln Ala Arg Arg Met 
                485                 490                 495     


Leu Thr Asn Lys Thr Trp Gly Leu Leu Ser Asp Asn Pro Arg Val Phe 
            500                 505                 510         


Ala Ala Asn Ala Glu Leu Val Gly Lys Lys Arg Asn Pro Gln Asp Arg 
        515                 520                 525             


Trp Lys Leu Phe Phe His Met Val Ile Ser Gly Pro Pro Pro Val Glu 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Ser Asp Val Arg Ser Arg Ala Arg Thr Val Ile 
545                 550                 555                 560 


Gly Ile Asn Arg Gly Glu Val Asn Pro Leu Ala Tyr Ala Val Val Ser 
                565                 570                 575     


Val Glu Asp Gly Gln Val Leu Glu Glu Gly Leu Leu Gly Lys Lys Glu 
            580                 585                 590         


Tyr Ile Asp Gln Leu Ile Glu Thr Arg Arg Arg Ile Ser Glu Tyr Gln 
        595                 600                 605             


Ser Arg Glu Gln Thr Pro Pro Arg Asp Leu Arg Gln Arg Val Arg His 
    610                 615                 620                 


Leu Gln Asp Thr Val Leu Gly Ser Ala Arg Ala Lys Ile His Ser Leu 
625                 630                 635                 640 


Ile Ala Phe Trp Lys Gly Ile Leu Ala Ile Glu Arg Leu Asp Asp Gln 
                645                 650                 655     


Phe His Gly Arg Glu Gln Lys Ile Ile Pro Lys Lys Thr Tyr Leu Ala 
            660                 665                 670         


Asn Lys Thr Gly Phe Met Asn Ala Leu Ser Phe Ser Gly Ala Val Arg 
        675                 680                 685             


Val Asp Lys Lys Gly Asn Pro Trp Gly Gly Met Ile Glu Ile Tyr Pro 
    690                 695                 700                 


Gly Gly Ile Ser Arg Thr Cys Thr Gln Cys Gly Thr Val Trp Leu Ala 
705                 710                 715                 720 


Arg Arg Pro Lys Asn Pro Gly His Arg Asp Ala Met Val Val Ile Pro 
                725                 730                 735     


Asp Ile Val Asp Asp Ala Ala Ala Thr Gly Phe Asp Asn Val Asp Cys 
            740                 745                 750         


Asp Ala Gly Thr Val Asp Tyr Gly Glu Leu Phe Thr Leu Ser Arg Glu 
        755                 760                 765             


Trp Val Arg Leu Thr Pro Arg Tyr Ser Arg Val Met Arg Gly Thr Leu 
    770                 775                 780                 


Gly Asp Leu Glu Arg Ala Ile Arg Gln Gly Asp Asp Arg Lys Ser Arg 
785                 790                 795                 800 


Gln Met Leu Glu Leu Ala Leu Glu Pro Gln Pro Gln Trp Gly Gln Phe 
                805                 810                 815     


Phe Cys His Arg Cys Gly Phe Asn Gly Gln Ser Asp Val Leu Ala Ala 
            820                 825                 830         


Thr Asn Leu Ala Arg Arg Ala Ile Ser Leu Ile Arg Arg Leu Pro Asp 
        835                 840                 845             


Thr Asp Thr Pro Pro Thr Pro 
    850                 855 


<210>  4
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  4
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag agaaaccgau aaguaaaacg caucaaag                   108


<210>  5
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  5
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  6
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  6
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  7
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  7
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  8
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  9
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  9
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  10
guuuacacac ucccucucau agggu                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  11
guuuacacac ucccucucau gaggu                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  12
uuuuacauac ccccucucau gggau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  13
guuuacacac ucccucucau ggggg                                             25


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  14
ccagcgacua ugucguaugg                                                   20


<210>  15
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  15
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  16
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  16
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cgga                                                         74


<210>  17
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgNA variant

<400>  17
attatctcat tact                                                         14


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  18
tccgagggga ccgtcccctc ggta                                              24


<210>  19
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  19
ggccggcatg gtcccagcct cctcgctggc gccggctggg aacat                       45


<210>  20
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  20
atggcgaatg ggaccc                                                       16


<210>  21
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  21
ttttggccgg catggtccca gcctcctcgc tggcgccggc tgggcaacat gcttcggcat       60

ggcgaatggg accccggg                                                     78


<210>  22
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  22
cccggggtcc cattcgccat gccgaagcat gttgcccagc cggcgccagc gaggaggctg       60

ggaccatgcc ggccaaaa                                                     78


<210>  23
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgNA variant

<400>  23
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttac ggacttcggt ccgtaagaag catcaaag                               98


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  24
gtgtagtaca agagatagaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  25
tgaagctgac agcattcggg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  26
tagatcgaga catgtaagca                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  27
ggccgagatg tctcgctccg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  28
aggccagaaa gagagagtag                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  29
tgtggtcggg gtagcggctg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  30
tcaagtccgc catgcccgaa                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  31
ccagggtgtc gccctcgaac                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  32
tgaccaccct gacctacggc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  33
tggggcacaa gctggagtac                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  34
gtcgtgctgc ttcatgcaac                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  35
gtcgtgctgc tttgcatggt                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  36
gtcgtgctat cccatgtggt                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  37
gtcgcatcgc ttcatgtggt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  38
actatgctgc ttcatgtggt                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  39
gtcgtgctgc ttcatacagt                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  40
gtcgtgctgc tttgcgtggt                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  41
gtcgtgctgt cccatgtggt                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  42
gtcgtgtcac ttcatgtggt                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  43
gtcacactgc ttcatgtggt                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  44
actgtgctgc ttcatgtggt                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  45
gtcgtgctgc ttcatgtgac                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  46
gtcgtgctgc ttcatgcagt                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  47
gtcgtgctgc ttcacatggt                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  48
gtcgtgctgc tttgtgtggt                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  49
gtcgtgctgc cccatgtggt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  50
gtcgtgctat ttcatgtggt                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  51
gtcgtgtcgc ttcatgtggt                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  52
gtcgcactgc ttcatgtggt                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  53
gttatgctgc ttcatgtggt                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  54
accgtgctgc ttcatgtggt                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  55
gtcgtgctgc ttcatgtgat                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  56
gtcgtgctgc ttcatgcggt                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  57
gtcgtgctgc ttcacgtggt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  58
gtcgtgctgc tttatgtggt                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  59
gtcgtgctgc ctcatgtggt                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  60
gtcgtgctac ttcatgtggt                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  61
gtcgtgttgc ttcatgtggt                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  62
gtcgcgctgc ttcatgtggt                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  63
gttgtgctgc ttcatgtggt                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  64
atcgtgctgc ttcatgtggt                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  65
gtcgtgctgc ttcatgtggt                                                   20


<210>  66
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  66
gaagtcgtgc tgcttcatgt aac                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  67
gaagtcgtgc tgcttcgcac ggt                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  68
gaagtcgtgc tgtcctatgt ggt                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  69
gaagtcgtat cacttcatgt ggt                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  70
gaagctacgc tgcttcatgt ggt                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  71
aggatcgtgc tgcttcatgt ggt                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  72
gaagtcgtgc tgcttcatgt gac                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  73
gaagtcgtgc tgcttcatac agt                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  74
gaagtcgtgc tgctttgcgt ggt                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  75
gaagtcgtgc tgtcccatgt ggt                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  76
gaagtcgtgt cacttcatgt ggt                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  77
gaagtcacac tgcttcatgt ggt                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  78
gaaactgtgc tgcttcatgt ggt                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  79
agggtcgtgc tgcttcatgt ggt                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  80
gaagtcgtgc tgcttcatgt aat                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  81
gaagtcgtgc tgcttcatac ggt                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  82
gaagtcgtgc tgcttcgcgt ggt                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  83
gaagtcgtgc tgctctatgt ggt                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  84
gaagtcgtgc tgtctcatgt ggt                                               23


<210>  85
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  85
gaagtcgtgc cacttcatgt ggt                                               23


<210>  86
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  86
gaagtcgtat tgcttcatgt ggt                                               23


<210>  87
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  87
gaagtcacgc tgcttcatgt ggt                                               23


<210>  88
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  88
gaagctgtgc tgcttcatgt ggt                                               23


<210>  89
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  89
gagatcgtgc tgcttcatgt ggt                                               23


<210>  90
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  90
agagtcgtgc tgcttcatgt ggt                                               23


<210>  91
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  91
gaagtcgtgc tgcttcatgt ggc                                               23


<210>  92
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  92
gaagtcgtgc tgcttcatgt agt                                               23


<210>  93
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  93
gaagtcgtgc tgcttcatat ggt                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  94
gaagtcgtgc tgcttcgtgt ggt                                               23


<210>  95
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  95
gaagtcgtgc tgctccatgt ggt                                               23


<210>  96
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  96
gaagtcgtgc tgtttcatgt ggt                                               23


<210>  97
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  97
gaagtcgtgc cgcttcatgt ggt                                               23


<210>  98
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  98
gaagtcgtac tgcttcatgt ggt                                               23


<210>  99
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  99
gaagtcatgc tgcttcatgt ggt                                               23


<210>  100
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  100
gaagccgtgc tgcttcatgt ggt                                               23


<210>  101
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  101
gaggtcgtgc tgcttcatgt ggt                                               23


<210>  102
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  102
aaagtcgtgc tgcttcatgt ggt                                               23


<210>  103
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  103
gaagtcgtgc tgcttcatgt ggt                                               23


<210>  104
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  104
agggcgacac cctggtaggt                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  105
agggcgacac cccaacgaac                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  106
agggcgacgt tttggtgaac                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  107
agggtagtac cctggtgaac                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  108
gaaacgacac cctggtgaac                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  109
agggcgacac cctggcagac                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  110
agggcgacac cccaatgaac                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  111
agggcgacat tttggtgaac                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  112
agggcggtgc cctggtgaac                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  113
aggataacac cctggtgaac                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  114
gaagcgacac cctggtgaac                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  115
agggcgacac cctggtgagt                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  116
agggcgacac cctggtagac                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  117
agggcgacac cctgacgaac                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  118
agggcgacac cccagtgaac                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  119
agggcgacac tttggtgaac                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  120
agggcgacgt cctggtgaac                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  121
agggcggtac cctggtgaac                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  122
agggtaacac cctggtgaac                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  123
agaacgacac cctggtgaac                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  124
gaggcgacac cctggtgaac                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  125
agggcgacac cctggtgagc                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  126
agggcgacac cctggtaaac                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  127
agggcgacac cctgatgaac                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  128
agggcgacac cccggtgaac                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  129
agggcgacac tctggtgaac                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  130
agggcgacgc cctggtgaac                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  131
agggcggcac cctggtgaac                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  132
agggtgacac cctggtgaac                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  133
agagcgacac cctggtgaac                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  134
ggggcgacac cctggtgaac                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  135
agggcgacac cctggtgaac                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  136
gaagttcgag ggtagtaccc                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  137
gaagttcgga aacgacaccc                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  138
gaagcctaag ggcgacaccc                                                   20


<210>  139
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  139
aggattcgag ggcgacaccc                                                   20


<210>  140
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  140
gaagttcgag ggcgatgtcc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  141
gaagttcgag ggtagcaccc                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  142
gaagttcgaa aacgacaccc                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  143
gaagtttagg ggcgacaccc                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  144
gaaacccgag ggcgacaccc                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  145
agggttcgag ggcgacaccc                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  146
gaagttcgag ggcgacactt                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  147
gaagttcgag ggcgacgtcc                                                   20


<210>  148
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  148
gaagttcgag ggcggtaccc                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  149
gaagttcgag ggtaacaccc                                                   20


<210>  150
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  150
gaagttcgag aacgacaccc                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  151
gaagttcgga ggcgacaccc                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  152
gaagtttaag ggcgacaccc                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  153
gaagcccgag ggcgacaccc                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  154
gagattcgag ggcgacaccc                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  155
agagttcgag ggcgacaccc                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  156
gaagttcgag ggcgacactc                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  157
gaagttcgag ggcgacgccc                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  158
gaagttcgag ggcggcaccc                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  159
gaagttcgag ggtgacaccc                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  160
gaagttcgag agcgacaccc                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  161
gaagttcggg ggcgacaccc                                                   20


<210>  162
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  162
gaagtttgag ggcgacaccc                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  163
gaagctcgag ggcgacaccc                                                   20


<210>  164
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  164
gaggttcgag ggcgacaccc                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  165
aaagttcgag ggcgacaccc                                                   20


<210>  166
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  166
gaagttcgag ggcgacaccc                                                   20


<210>  167
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  167
tcgccctcga acttcacctc aat                                               23


<210>  168
<211>  24
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  168
tcgccctcga acttcattcc tggc                                              24


<210>  169
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  169
tcgccctcga accctgcctc ggc                                               23


<210>  170
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  170
tcgccctcag gtttcacctc ggc                                               23


<210>  171
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  171
tcgcttctga acttcacctc ggc                                               23


<210>  172
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  172
ctatcctcga acttcacctc ggc                                               23


<210>  173
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  173
tcgccctcga acttcacctc gat                                               23


<210>  174
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  174
tcgccctcga acttcaccct agc                                               23


<210>  175
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  175
tcgccctcga acttcgtttc ggc                                               23


<210>  176
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  176
tcgccctcga accctacctc ggc                                               23


<210>  177
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  177
tcgccctcgg gtttcacctc ggc                                               23


<210>  178
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  178
tcgcccctaa acttcacctc ggc                                               23


<210>  179
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  179
tcgttttcga acttcacctc ggc                                               23


<210>  180
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  180
ctaccctcga acttcacctc ggc                                               23


<210>  181
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  181
tcgccctcga acttcacctc aac                                               23


<210>  182
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  182
tcgccctcga acttcaccct ggc                                               23


<210>  183
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  183
tcgccctcga acttcatttc ggc                                               23


<210>  184
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  184
tcgccctcga actttgcctc ggc                                               23


<210>  185
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  185
tcgccctcga accccacctc ggc                                               23


<210>  186
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  186
tcgccctcga gtttcacctc ggc                                               23


<210>  187
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  187
tcgccctcag acttcacctc ggc                                               23


<210>  188
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  188
tcgcccctga acttcacctc ggc                                               23


<210>  189
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  189
tcgctttcga acttcacctc ggc                                               23


<210>  190
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  190
tcatcctcga acttcacctc ggc                                               23


<210>  191
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  191
ctgccctcga acttcacctc ggc                                               23


<210>  192
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  192
tcgccctcga acttcacctc ggt                                               23


<210>  193
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  193
tcgccctcga acttcacctc agc                                               23


<210>  194
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  194
tcgccctcga acttcacccc ggc                                               23


<210>  195
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  195
tcgccctcga acttcatctc ggc                                               23


<210>  196
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  196
tcgccctcga actttacctc ggc                                               23


<210>  197
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  197
tcgccctcga acctcacctc ggc                                               23


<210>  198
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  198
tcgccctcga gcttcacctc ggc                                               23


<210>  199
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  199
tcgccctcaa acttcacctc ggc                                               23


<210>  200
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  200
tcgcccccga acttcacctc ggc                                               23


<210>  201
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  201
tcgctctcga acttcacctc ggc                                               23


<210>  202
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  202
tcaccctcga acttcacctc ggc                                               23


<210>  203
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  203
ccgccctcga acttcacctc ggc                                               23


<210>  204
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  204
tcgccctcga acttcacctc ggc                                               23


<210>  205
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  205
tgtggtcggg gtagcgatca                                                   20


<210>  206
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  206
tgtggtcggg gtgatagctg                                                   20


<210>  207
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  207
tgtggtcgaa acagcggctg                                                   20


<210>  208
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  208
tgtgactagg gtagcggctg                                                   20


<210>  209
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  209
cacagtcggg gtagcggctg                                                   20


<210>  210
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  210
tgtggtcggg gtagcaattg                                                   20


<210>  211
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  211
tgtggtcggg gtgatggctg                                                   20


<210>  212
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  212
tgtggtcgga acagcggctg                                                   20


<210>  213
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  213
tgtggttaag gtagcggctg                                                   20


<210>  214
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  214
tgtaaccggg gtagcggctg                                                   20


<210>  215
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  215
cacggtcggg gtagcggctg                                                   20


<210>  216
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  216
tgtggtcggg gtagcggcca                                                   20


<210>  217
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  217
tgtggtcggg gtagcgattg                                                   20


<210>  218
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  218
tgtggtcggg gtagtagctg                                                   20


<210>  219
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  219
tgtggtcggg gtgacggctg                                                   20


<210>  220
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  220
tgtggtcggg acagcggctg                                                   20


<210>  221
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  221
tgtggtcgaa gtagcggctg                                                   20


<210>  222
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  222
tgtggttagg gtagcggctg                                                   20


<210>  223
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  223
tgtgaccggg gtagcggctg                                                   20


<210>  224
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  224
tgcagtcggg gtagcggctg                                                   20


<210>  225
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  225
catggtcggg gtagcggctg                                                   20


<210>  226
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  226
tgtggtcggg gtagcggccg                                                   20


<210>  227
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  227
tgtggtcggg gtagcgactg                                                   20


<210>  228
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  228
tgtggtcggg gtagtggctg                                                   20


<210>  229
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  229
tgtggtcggg gtggcggctg                                                   20


<210>  230
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  230
tgtggtcggg atagcggctg                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  231
tgtggtcgag gtagcggctg                                                   20


<210>  232
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  232
tgtggttggg gtagcggctg                                                   20


<210>  233
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  233
tgtgatcggg gtagcggctg                                                   20


<210>  234
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  234
tgcggtcggg gtagcggctg                                                   20


<210>  235
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  235
cgtggtcggg gtagcggctg                                                   20


<210>  236
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  236
tgtggtcggg gtagcggctg                                                   20


<210>  237
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  scaffold stem loop of an exemplary reference sgRNA

<400>  237
ccaucaccag cgacuauguc guaugg                                            26


<210>  238
<211>  46
<212>  RNA
<213>  Unknown

<220>
<223>  extended stem loop sequence of an exemplary reference sgRNA

<400>  238
guaaacgcuu auuuaucgga gagaaauccg auaaauaaga agcauc                      46


<210>  239
<211>  68
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacter sp.

<400>  239
uuauuccauu acuuuggagc cagucccagc gacuaugucg uauggacgaa gcgcuuauuu       60

aucggaga                                                                68


<210>  240
<211>  65
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacter sp.

<400>  240
uuauuccauu acuuuggagc cagucccagc gacuaugucg uauggacgaa gcgcuuauuu       60

aucgg                                                                   65


<210>  241
<211>  23
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacter sp.

<400>  241
ccgauaagua aaacgcauca aag                                               23


<210>  242
<211>  69
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  242
uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu       60

uaucggaga                                                               69


<210>  243
<211>  66
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  243
uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu       60

uaucgg                                                                  66


<210>  244
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  244
ucuccgauaa auaagaagca ucaaag                                            26


<210>  245
<211>  230
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  245
uaaauuuuuu gagcccuauc uccgcgagga agacagggcu cuuuucauga gaggaagcuu       60

uuauacccga ccgguaaucc ggucggggga uuggccguug aaacgauuuu aaagcggcca      120

augggccccu cuauauggau acuacuuaua uaaggagcuu ggggaagaag auagcuuaau      180

cccgcuaucu ugucaagggg uugggggagu aucaguaucc ggcaggcgcc                 230


<210>  246
<211>  24
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  246
guuuacacac ucccucucau aggg                                              24


<210>  247
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  247
nnttcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  248
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  248
nnctcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  249
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  249
nngtcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  250
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  250
nnatcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  251
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  251
nnntcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  252
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  252

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  253
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  253

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Thr Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser 
            820                 825                 830         


Asp Gly Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu 
    850                 855                 860                 


Leu Ser Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu 
            900                 905                 910         


Asp Cys Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  254
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  254

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys 
        195                 200                 205             


Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn 
                245                 250                 255     


Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu 
            260                 265                 270         


Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro 
305                 310                 315                 320 


Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg Arg 
                325                 330                 335     


Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys Leu 
            340                 345                 350         


Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val Thr 
        355                 360                 365             


Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro Asn 
    370                 375                 380                 


Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys Lys 
385                 390                 395                 400 


Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys Lys 
                405                 410                 415     


Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg Ile 
            420                 425                 430         


Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu Ala 
        435                 440                 445             


Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp Leu 
    450                 455                 460                 


Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp Glu 
465                 470                 475                 480 


Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly Asp 
                485                 490                 495     


Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val Asp 
            500                 505                 510         


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
        515                 520                 525             


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
    530                 535                 540                 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
545                 550                 555                 560 


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
                565                 570                 575     


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
            580                 585                 590         


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
        595                 600                 605             


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
    610                 615                 620                 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
625                 630                 635                 640 


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
                645                 650                 655     


Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg 
            660                 665                 670         


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
        675                 680                 685             


Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu 
    690                 695                 700                 


Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala 
705                 710                 715                 720 


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala 
                725                 730                 735     


Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg 
            740                 745                 750         


Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu 
        755                 760                 765             


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr 
    770                 775                 780                 


Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
785                 790                 795                 800 


Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln 
                805                 810                 815     


Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala 
            820                 825                 830         


Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly Trp 
        835                 840                 845             


Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr 
    850                 855                 860                 


Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser Ala 
865                 870                 875                 880 


Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys 
                885                 890                 895     


Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg 
            900                 905                 910         


Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys Gly 
        915                 920                 925             


His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser 
    930                 935                 940                 


Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser 
945                 950                 955                 960 


Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg 
                965                 970                 975     


Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985 


<210>  255
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  255

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
            820                 825                 830         


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
        835                 840                 845             


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
865                 870                 875                 880 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
                885                 890                 895     


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
        915                 920                 925             


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  256
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  256

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala 
        915                 920     


<210>  257
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  257

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala 
        915                 920 


<210>  258
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  258

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Asn Ala Ala 
    50                  55                  60                  


Asn Asn Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala 
65                  70                  75                  80  


Ile Leu Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu 
                85                  90                  95      


Met Cys Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  259
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  259

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  260
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  260

Met Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro 
        35                  40                  45              


Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu 
    50                  55                  60                  


Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu 
65                  70                  75                  80  


Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr 
                85                  90                  95      


Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu 
            100                 105                 110         


Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser 
        115                 120                 125             


Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val 
    130                 135                 140                 


Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly 
145                 150                 155                 160 


Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys 
                165                 170                 175     


Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu 
            180                 185                 190         


Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu 
        195                 200                 205             


Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu 
    210                 215                 220                 


Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val 
225                 230                 235                 240 


Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu 
                245                 250                 255     


Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe 
            260                 265                 270         


Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp 
        275                 280                 285             


Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp 
    290                 295                 300                 


Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala 
305                 310                 315                 320 


Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys 
                325                 330                 335     


Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys 
            340                 345                 350         


His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile 
        355                 360                 365             


Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu 
    370                 375                 380                 


Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu 
385                 390                 395                 400 


Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys 
                405                 410                 415     


Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp 
            420                 425                 430         


Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Arg Val Val Asp 
        435                 440                 445             


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
    450                 455                 460                 


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
465                 470                 475                 480 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
                485                 490                 495     


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
            500                 505                 510         


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
        515                 520                 525             


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
    530                 535                 540                 


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
545                 550                 555                 560 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
                565                 570                 575     


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
            580                 585                 590         


Val Asp Pro Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg 
        595                 600                 605             


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
    610                 615                 620                 


Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys 
                645                 650                 655     


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala 
            660                 665                 670         


Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg 
        675                 680                 685             


Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu 
    690                 695                 700                 


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala 
705                 710                 715                 720 


Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
                725                 730                 735     


Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr 
            740                 745                 750         


Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp 
        755                 760                 765             


Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met 
    770                 775                 780                 


Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr 
785                 790                 795                 800 


Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu 
                805                 810                 815     


Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp 
            820                 825                 830         


Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe 
        835                 840                 845             


Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe 
    850                 855                 860                 


Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp 
865                 870                 875                 880 


Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr 
                885                 890                 895     


Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe 
            900                 905                 910         


Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
        915                 920                 925 


<210>  261
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  261

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Thr Ser Arg Ala Asn 
    50                  55                  60                  


Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu 
65                  70                  75                  80  


His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser 
                85                  90                  95      


Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys 
        195                 200                 205             


Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn 
                245                 250                 255     


Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu 
            260                 265                 270         


Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln 
                325                 330                 335     


Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  262
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  262

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly 
            500                 505                 510         


Ser Asp Gly His Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr 
        515                 520                 525             


Leu Glu Asn Gly Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys 
    530                 535                 540                 


Lys Gly Arg Ile Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Trp Gln Gly Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp 
                565                 570                 575     


Leu Thr Phe Asp Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala 
            580                 585                 590         


Phe Gly Thr Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Gly Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys 
    610                 615                 620                 


Thr Ile Tyr Asn Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val 
625                 630                 635                 640 


Ala Leu Thr Phe Glu Arg Arg Glu Val Val Asp Pro Ser Asn Ile Lys 
                645                 650                 655     


Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val 
            660                 665                 670         


Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp 
        675                 680                 685             


Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys 
    690                 695                 700                 


Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg 
705                 710                 715                 720 


Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala 
                725                 730                 735     


Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val 
            740                 745                 750         


Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly 
        755                 760                 765             


Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met 
    770                 775                 780                 


Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr 
785                 790                 795                 800 


Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn 
                805                 810                 815     


Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys 
            820                 825                 830         


Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu 
        835                 840                 845             


Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln 
    850                 855                 860                 


Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu 
865                 870                 875                 880 


Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu 
                885                 890                 895     


Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu 
            900                 905                 910         


Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln 
        915                 920                 925             


Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu 
    930                 935                 940                 


Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg 
945                 950                 955                 960 


Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970                 975     


Val Trp Lys Pro Ala Val 
            980         


<210>  263
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  263

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  264
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  264

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala 
    


<210>  265
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  265

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  266
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  266

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  267
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  267

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  268
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  268

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  269
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  269

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  270
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  270

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  271
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  271

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  272
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  272

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  273
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  273

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  274
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  274

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  275
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  275

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  276
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  276

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  277
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  277

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  278
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  278

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  279
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  279

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  280
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  280

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  281
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  281

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  282
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  282

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  283
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  283

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  284
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  284

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  285
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  285

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  286
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  286

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  287
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  287

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  288
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  288

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  289
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  289

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  290
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  290

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  291
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  291

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  292
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  292

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  293
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  293

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  294
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  294

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  295
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  295

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  296
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  296

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  297
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  297

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  298
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  298

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  299
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  299

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  300
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  300

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  301
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  301

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  302
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  302

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  303
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  303

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  304
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  304

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  305
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  305

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  306
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  306

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  307
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  307

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  308
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  308

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  309
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  309

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  310
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  310

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  311
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  311

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  312
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  312

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  313
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  313

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  314
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  314

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  315
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  315

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  316
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  316

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  317
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  317

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  318
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  318

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  319
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  319

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  320
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  320

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  321
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  321

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  322
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  322

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  323
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  323

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  324
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  324

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  325
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  325

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  326
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  326

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  327
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  327

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  328
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  328

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  329
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  329

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  330
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  330

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  331
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  331

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  332
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  332

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  333
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  333

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  334
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  334

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  335
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  335

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  336
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  336

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  337
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  337

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  338
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  338

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  339
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  339

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  340
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  340

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  341
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  341

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  342
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  342

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  343
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  343

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  344
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  344

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  345
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  345

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  346
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  346

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  347
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  347

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  348
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  348

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  349
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  349

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  350
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  350

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  351
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  351

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  352
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  352

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  353
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold stem loop

<400>  353
ccagcgacua ugucguagug g                                                 21


<210>  354
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  354
acaugaggau uacccaugu                                                    19


<210>  355
<211>  18
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  355
ugcaugucua agacagca                                                     18


<210>  356
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  356
aauccauugc acuccggauu                                                   20


<210>  357
<211>  12
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  357
ccucuucgga gg                                                           12


<210>  358
<211>  21
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  358
aggaguuucu auggaaaccc u                                                 21


<210>  359
<211>  30
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  359
aggugggacg accucucggu cguccuaucu                                        30


<210>  360
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  360
ugcucgcucc guucgagca                                                    19


<210>  361
<211>  21
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  361
ugcucgacgc guccucgagc a                                                 21


<210>  362
<211>  22
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  362
ugcucguuug cggcuacgag ca                                                22


<210>  363
<211>  17
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  363
agggagggag ggagagg                                                      17


<210>  364
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  364
gguuaggguu aggguuagg                                                    19


<210>  365
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  365
cugcucagua cgagaggaac cgcag                                             25


<210>  366
<211>  78
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  366
uacacuggga ucgcugaauu agagaucggc guccuuucau ucuauauacu uuggaguuuu       60

aaaaugucuc uaaguaca                                                     78


<210>  367
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  367
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  368
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  368
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  369
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  369
cctggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  370
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  370
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  371
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  371
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  372
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  372
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  373
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  373
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  374
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  374
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  375
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  375
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  376
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  376
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  377
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  377
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  378
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  378
cctggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  379
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  379
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  380
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  380
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  381
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  381
tactggcgct tttatctcat tactttgtag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  382
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  382
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  383
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  383
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  384
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  384
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tagtgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  385
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  385
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  386
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  386
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  387
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  387
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  388
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  388
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  389
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  389
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  390
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  390
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  391
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  391
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  392
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  392
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  393
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  393
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  394
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  394
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  395
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  395
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  396
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  396
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  397
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  397
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  398
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  398
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  399
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  399
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  400
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  400
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaccgataa ataagaagca tcaaag                     106


<210>  401
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  401
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  402
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  402
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  403
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  403
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  404
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  404
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  405
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  405
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  406
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  406
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  407
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  407
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  408
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  408
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  409
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  409
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  410
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  410
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  411
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  411
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  412
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  412
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  413
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  413
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  414
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  414
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  415
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  415
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  416
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  416
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  417
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  417
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  418
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  418
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  419
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  419
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  420
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  420
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  421
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  421
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  422
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  422
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  423
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  423
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  424
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  424
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  425
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  425
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  426
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  426
gctggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  427
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  427
tactggcgct tttatctcat tactttgctc attactttga gagccatcac cagcgactat       60

gtcgtatggg taaagcgctt atttatgcgg agagaaatcc gataaataag aagcatcaaa      120

g                                                                      121


<210>  428
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  428
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  429
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  429
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  430
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  430
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  431
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  431
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  432
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  432
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  433
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  433
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  434
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  434
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  435
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  435
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  436
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  436
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  437
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  437
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  438
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  438
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  439
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  439
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  440
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  440
tctggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  441
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  441
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  442
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  442
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  443
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  443
tactggcgct tttatctcat tactttgtag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  444
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  444
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  445
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  445
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  446
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  446
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  447
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  447
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  448
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  448
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  449
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  449
tctggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  450
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  450
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  451
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  451
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  452
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  452
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  453
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  453
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  454
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  454
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  455
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  455
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  456
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  456
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  457
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  457
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  458
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  458
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  459
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  459
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  460
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  460
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  461
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  461
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  462
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  462
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  463
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  463
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  464
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  464
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  465
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  465
tctggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  466
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  466
cctggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  467
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  467
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctggagag aaatccgata aataagaagc atcaaag                    107


<210>  468
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  468
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  469
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  469
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  470
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  470
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  471
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  471
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  472
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  472
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  473
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  473
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  474
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  474
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  475
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  475
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  476
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  476
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  477
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  477
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  478
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  478
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  479
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  479
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  480
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  480
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  481
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  481
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  482
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  482
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  483
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  483
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  484
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  484
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  485
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  485
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  486
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  486
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  487
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  487
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  488
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  488
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  489
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  489
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  490
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  490
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  491
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  491
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  492
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  492
tcggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  493
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  493
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  494
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  494
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  495
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  495
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  496
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  496
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  497
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  497
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  498
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  498
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  499
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  499
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  500
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  500
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  501
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  501
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  502
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  502
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  503
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  503
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attgagagaa atccgataaa taagaagcat caaag                      105


<210>  504
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  504
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  505
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  505
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  506
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  506
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  507
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  507
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  508
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  508
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  509
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  509
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  510
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  510
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aaccgataaa taagaagcat caaag                      105


<210>  511
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  511
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  512
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  512
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  513
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  513
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  514
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  514
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  515
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  515
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  516
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  516
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  517
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  517
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt aatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  518
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  518
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  519
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  519
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  520
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  520
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  521
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  521
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  522
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  522
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  523
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  523
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  524
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  524
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  525
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  525
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  526
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  526
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  527
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  527
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  528
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  528
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  529
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  529
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  530
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  530
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  531
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  531
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgag aaatccgata aataagaagc atcaaag                    107


<210>  532
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  532
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  533
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  533
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagag aaatccgata aataagaagc atcaaag                    107


<210>  534
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  534
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  535
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  535
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  536
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  536
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  537
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  537
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  538
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  538
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  539
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  539
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  540
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  540
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgggagaaa tccgataaat aagaagcatc aaag                       104


<210>  541
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  541
cctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  542
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  542
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag attccgataa ataagaagca tcaaag                     106


<210>  543
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  543
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aataccgata aataagaagc atcaaag                    107


<210>  544
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  544
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  545
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  545
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  546
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  546
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  547
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  547
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  548
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  548
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  549
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  549
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  550
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  550
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  551
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  551
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  552
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  552
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcctgata aataagaagc atcaaag                    107


<210>  553
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  553
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  554
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  554
cctggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  555
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  555
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  556
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  556
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  557
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  557
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  558
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  558
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  559
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  559
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  560
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  560
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  561
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  561
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  562
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  562
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  563
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  563
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  564
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  564
actggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  565
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  565
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  566
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  566
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  567
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  567
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggacga aatccgataa ataagaagca tcaaag                     106


<210>  568
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  568
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  569
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  569
gctggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  570
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  570
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  571
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  571
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  572
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  572
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  573
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  573
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  574
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  574
actggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  575
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  575
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  576
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  576
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  577
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  577
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  578
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  578
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atacggagag aaatccgata aataagaagc atcaaag                    107


<210>  579
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  579
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  580
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  580
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  581
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  581
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  582
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  582
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  583
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  583
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  584
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  584
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  585
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  585
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  586
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  586
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  587
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  587
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggag aaatccgata aataagaagc atcaaag                    107


<210>  588
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  588
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gagaaatccg ataaataaga agcatcaaag                 110


<210>  589
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  589
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  590
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  590
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  591
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  591
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  592
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  592
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  593
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  593
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  594
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  594
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  595
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  595
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  596
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  596
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  597
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  597
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  598
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  598
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  599
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  599
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  600
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  600
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  601
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  601
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  602
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  602
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  603
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  603
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  604
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  604
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  605
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  605
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  606
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  606
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  607
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  607
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  608
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  608
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  609
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  609
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  610
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  610
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  611
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  611
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggaa ataagaagca tcaaag                     106


<210>  612
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  612
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  613
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  613
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  614
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  614
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  615
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  615
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  616
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  616
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  617
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  617
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  618
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  618
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  619
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  619
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  620
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  620
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  621
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  621
cctggcgctt ttatctcatt actttagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  622
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  622
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  623
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  623
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  624
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  624
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  625
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  625
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  626
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  626
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  627
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  627
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  628
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  628
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  629
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  629
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  630
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  630
cctggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  631
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  631
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  632
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  632
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  633
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  633
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  634
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  634
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  635
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  635
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  636
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  636
cctggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  637
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  637
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  638
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  638
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtagaa atccgataaa taagaagcat caaag                      105


<210>  639
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  639
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  640
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  640
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  641
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  641
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  642
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  642
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  643
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  643
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  644
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  644
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaagcgat aaataagaag catcaaag                   108


<210>  645
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  645
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ataatccgat aaataagaag catcaaag                   108


<210>  646
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  646
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  647
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  647
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  648
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  648
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgag aaatccgata aataagaagc atcaaag                    107


<210>  649
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  649
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  650
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  650
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  651
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  651
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  652
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  652
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  653
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  653
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  654
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  654
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  655
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  655
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  656
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  656
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  657
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  657
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcacgata aataagaagc atcaaag                    107


<210>  658
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  658
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  659
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  659
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcagaa atccgataaa taagaagcat caaag                      105


<210>  660
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  660
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  661
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  661
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  662
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  662
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  663
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  663
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  664
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  664
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  665
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  665
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  666
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  666
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  667
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  667
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgact aaataagaag catcaaag                   108


<210>  668
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  668
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  669
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  669
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  670
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  670
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  671
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  671
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggatga aatccgataa ataagaagca tcaaag                     106


<210>  672
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  672
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  673
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  673
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  674
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  674
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  675
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  675
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  676
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  676
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  677
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  677
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  678
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  678
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgtata aataagaagc atcaaag                    107


<210>  679
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  679
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  680
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  680
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  681
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  681
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  682
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  682
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  683
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  683
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  684
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  684
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  685
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  685
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  686
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  686
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  687
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  687
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtaga gaaatccgat aaataagaag catcaaag                   108


<210>  688
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  688
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  689
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  689
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  690
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  690
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  691
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  691
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  692
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  692
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  693
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  693
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atacggagag aaatccgata aataagaagc atcaaag                    107


<210>  694
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  694
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  695
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  695
tctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  696
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  696
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag atccgataaa taagaagcat caaag                      105


<210>  697
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  697
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  698
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  698
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  699
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  699
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  700
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  700
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  701
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  701
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  702
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  702
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  703
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  703
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  704
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  704
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  705
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  705
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgaata aataagaagc atcaaag                    107


<210>  706
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  706
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  707
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  707
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  708
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  708
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  709
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  709
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  710
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  710
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  711
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  711
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attgagagaa atccgataaa taagaagcat caaag                      105


<210>  712
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  712
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agagtccgat aaataagaag catcaaag                   108


<210>  713
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  713
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  714
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  714
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  715
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  715
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  716
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  716
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  717
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  717
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  718
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  718
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  719
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  719
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  720
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  720
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  721
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  721
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  722
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  722
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  723
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  723
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  724
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  724
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcagag aaatccgata aataagaagc atcaaag                    107


<210>  725
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  725
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  726
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  726
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  727
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  727
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  728
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  728
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  729
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  729
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  730
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  730
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  731
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  731
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgtgagaa atccgataaa taagaagcat caaag                      105


<210>  732
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  732
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattgataa ataagaagca tcaaag                     106


<210>  733
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  733
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaccgataaa taagaagcat caaag                      105


<210>  734
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  734
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  735
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  735
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  736
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  736
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta atccgataaa taagaagcat caaag                      105


<210>  737
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  737
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  738
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  738
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  739
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  739
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  740
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  740
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  741
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  741
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aattgataaa taagaagcat caaag                      105


<210>  742
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  742
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  743
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  743
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agtccgataa ataagaagca tcaaag                     106


<210>  744
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  744
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgagt aaataagaag catcaaag                   108


<210>  745
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  745
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  746
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  746
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  747
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  747
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  748
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  748
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  749
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  749
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  750
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  750
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  751
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  751
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaatccgat aaataagaag catcaaag                   108


<210>  752
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  752
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  753
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  753
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  754
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  754
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  755
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  755
cctggcgctt ttatctcatt actttgtaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  756
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  756
ctggcgcttt tatctcatta ctttcgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  757
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  757
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  758
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  758
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  759
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  759
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  760
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  760
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  761
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  761
tactggcgct tttatctcat tactttgctc attactttga gagccatcac cagcgactat       60

gtcgtatggg taaagcgctt atttatacgg agagaaatcc gataaataag aagcatcaaa      120

g                                                                      121


<210>  762
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  762
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  763
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  763
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  764
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  764
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  765
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  765
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  766
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  766
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  767
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  767
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  768
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  768
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  769
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  769
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  770
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  770
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  771
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  771
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgcgataa ataagaagca tcaaag                     106


<210>  772
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  772
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  773
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  773
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  774
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  774
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  775
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  775
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  776
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  776
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  777
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  777
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tctagagaaa tccgataaat aagaagcatc aaag                       104


<210>  778
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  778
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcaga gaaatccgat aaataagaag catcaaag                   108


<210>  779
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  779
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  780
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  780
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  781
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  781
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagca aatccgataa ataagaagca tcaaag                     106


<210>  782
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  782
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga aaataagaag catcaaag                   108


<210>  783
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  783
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  784
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  784
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  785
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  785
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  786
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  786
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  787
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  787
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcaagagaaa tccgataaat aagaagcatc aaag                       104


<210>  788
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  788
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  789
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  789
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  790
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  790
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  791
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  791
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  792
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  792
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  793
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  793
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  794
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  794
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  795
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  795
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  796
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  796
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  797
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  797
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  798
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  798
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aagcgataaa taagaagcat caaag                      105


<210>  799
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  799
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  800
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  800
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  801
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  801
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  802
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  802
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  803
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  803
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gatccgataa ataagaagca tcaaag                     106


<210>  804
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  804
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag acaatccgat aaataagaag catcaaag                   108


<210>  805
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  805
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  806
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  806
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  807
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  807
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  808
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  808
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taaatccgat aaataagaag catcaaag                   108


<210>  809
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  809
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  810
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  810
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  811
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  811
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  812
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  812
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  813
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  813
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  814
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  814
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aagccgataa ataagaagca tcaaag                     106


<210>  815
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  815
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  816
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  816
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  817
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  817
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  818
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  818
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  819
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  819
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  820
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  820
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  821
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  821
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcggtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  822
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  822
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  823
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  823
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  824
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  824
gctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  825
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  825
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagtg aaatccgata aataagaagc atcaaag                    107


<210>  826
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  826
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  827
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  827
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggaa ataagaagca tcaaag                     106


<210>  828
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  828
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  829
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  829
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  830
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  830
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  831
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  831
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  832
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  832
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  833
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  833
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  834
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  834
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  835
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  835
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  836
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  836
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  837
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  837
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  838
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  838
cctggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  839
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  839
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  840
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  840
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  841
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  841
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  842
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  842
tctggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  843
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  843
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  844
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  844
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  845
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  845
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  846
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  846
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  847
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  847
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  848
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  848
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  849
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  849
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  850
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  850
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  851
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  851
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttatta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  852
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  852
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  853
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  853
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  854
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  854
tactggcgct tttatctcat tactttgtag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  855
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  855
ctggcgcttt tatctcatta ctttagagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  856
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  856
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgcgagaa atccgataaa taagaagcat caaag                      105


<210>  857
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  857
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta atccgataaa taagaagcat caaag                      105


<210>  858
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  858
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  859
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  859
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  860
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  860
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  861
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  861
tacggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  862
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  862
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  863
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  863
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  864
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  864
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attgagagaa atccgataaa taagaagcat caaag                      105


<210>  865
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  865
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  866
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  866
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gatccgataa ataagaagca tcaaag                     106


<210>  867
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  867
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  868
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  868
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgtaaa taagaagcat caaag                      105


<210>  869
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  869
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  870
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  870
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  871
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  871
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcaagagaaa tccgataaat aagaagcatc aaag                       104


<210>  872
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  872
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  873
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  873
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  874
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  874
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  875
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  875
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  876
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  876
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagcaa atccgataaa taagaagcat caaag                      105


<210>  877
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  877
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  878
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  878
gctggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  879
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  879
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  880
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  880
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  881
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  881
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  882
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  882
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  883
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  883
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcagata aataagaagc atcaaag                    107


<210>  884
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  884
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  885
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  885
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagca aatccgataa ataagaagca tcaaag                     106


<210>  886
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  886
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  887
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  887
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaatccgat aaataagaag catcaaag                   108


<210>  888
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  888
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggaa ataagaagca tcaaag                     106


<210>  889
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  889
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag actccgataa ataagaagca tcaaag                     106


<210>  890
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  890
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  891
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  891
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aaacgataaa taagaagcat caaag                      105


<210>  892
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  892
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  893
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  893
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  894
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  894
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  895
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  895
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  896
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  896
tacggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  897
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  897
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  898
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  898
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatggaga gaaatccgat aaataagaag catcaaag                   108


<210>  899
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  899
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  900
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  900
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  901
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  901
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  902
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  902
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  903
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  903
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  904
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  904
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  905
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  905
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  906
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  906
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgcata aataagaagc atcaaag                    107


<210>  907
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  907
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  908
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  908
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  909
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  909
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atggagagaa atccgataaa taagaagcat caaag                      105


<210>  910
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  910
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  911
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  911
actggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  912
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  912
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  913
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  913
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  914
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  914
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  915
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  915
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  916
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  916
actggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  917
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  917
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  918
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  918
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  919
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  919
gctggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  920
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  920
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  921
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  921
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagagagc atcaaag                    107


<210>  922
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  922
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  923
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  923
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  924
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  924
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatggataa ataagaagca tcaaag                     106


<210>  925
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  925
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  926
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  926
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  927
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  927
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  928
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  928
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggag aaatccgata aataagaagc atcaaag                    107


<210>  929
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  929
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  930
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  930
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaaa ataagaagca tcaaag                     106


<210>  931
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  931
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  932
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  932
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  933
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  933
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  934
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  934
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  935
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  935
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  936
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  936
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  937
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  937
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acccgataaa taagaagcat caaag                      105


<210>  938
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  938
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  939
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  939
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  940
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  940
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  941
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  941
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  942
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  942
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  943
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  943
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  944
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  944
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  945
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  945
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  946
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  946
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccagagaaa tccgataaat aagaagcatc aaag                       104


<210>  947
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  947
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  948
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  948
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  949
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  949
actggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  950
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  950
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgaaaa taagaagcat caaag                      105


<210>  951
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  951
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  952
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  952
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  953
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  953
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccggt aaataagaag catcaaag                   108


<210>  954
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  954
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  955
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  955
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  956
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  956
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  957
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  957
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  958
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  958
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  959
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  959
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gcggagagaa atccgataaa taagaagcat caaag                      105


<210>  960
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  960
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  961
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  961
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  962
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  962
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  963
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  963
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  964
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  964
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  965
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  965
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  966
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  966
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgaa atccgataaa taagaagcat caaag                      105


<210>  967
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  967
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  968
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  968
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  969
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  969
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  970
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  970
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  971
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  971
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcagat aaataagaag catcaaag                   108


<210>  972
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  972
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  973
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  973
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  974
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  974
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  975
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  975
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattcgata aataagaagc atcaaag                    107


<210>  976
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  976
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  977
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  977
tctggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  978
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  978
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  979
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  979
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  980
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  980
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  981
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  981
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aagccgataa ataagaagca tcaaag                     106


<210>  982
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  982
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  983
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  983
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  984
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  984
cctggcgctt ttatctcgat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  985
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  985
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  986
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  986
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gaaatccgat aaataagaag catcaaag                   108


<210>  987
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  987
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  988
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  988
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  989
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  989
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tggagagaaa tccgataaat aagaagcatc aaag                       104


<210>  990
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  990
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  991
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  991
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  992
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  992
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  993
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  993
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  994
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  994
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccat aaataagaag catcaaag                   108


<210>  995
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  995
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  996
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  996
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  997
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  997
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  998
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  998
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  999
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  999
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tcttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1000
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1000
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1001
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1001
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1002
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1002
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  1003
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1003
ttactggcgc ttttatctca ttactttcga gagccatcac cagcgactat gtcgtatggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1004
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1004
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  1005
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1005
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt actcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1006
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1006
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1007
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1007
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatagataa ataagaagca tcaaag                     106


<210>  1008
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1008
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1009
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1009
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtagag aaatccgata aataagaagc atcaaag                    107


<210>  1010
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1010
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1011
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1011
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1012
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1012
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtagag aaatccgata aataagaagc atcaaag                    107


<210>  1013
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1013
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1014
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1014
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcagagaa atccgataaa taagaagcat caaag                      105


<210>  1015
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1015
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1016
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1016
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1017
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1017
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  1018
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1018
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1019
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1019
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1020
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1020
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1021
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1021
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  1022
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1022
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1023
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1023
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1024
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1024
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1025
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1025
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agacaatccg ataaataaga agcatcaaag                 110


<210>  1026
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1026
gctggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1027
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1027
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  1028
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1028
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaggaa atccgataaa taagaagcat caaag                      105


<210>  1029
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1029
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1030
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1030
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  1031
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1031
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaaag catcaaag                   108


<210>  1032
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1032
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  1033
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1033
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1034
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1034
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  1035
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1035
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  1036
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1036
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1037
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1037
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1038
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1038
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1039
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1039
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1040
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1040
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatagataa ataagaagca tcaaag                     106


<210>  1041
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1041
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1042
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1042
tctggcgctt ttatctcatt actttagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1043
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1043
actggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1044
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1044
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1045
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1045
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1046
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1046
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1047
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1047
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgt aaataagaag catcaaag                   108


<210>  1048
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1048
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1049
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1049
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcgat aaataagaag catcaaag                   108


<210>  1050
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1050
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1051
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1051
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  1052
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1052
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1053
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1053
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  1054
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1054
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1055
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1055
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatgccgata aataagaagc atcaaag                    107


<210>  1056
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1056
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  1057
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1057
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1058
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1058
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1059
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1059
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga gtccgataaa taagaagcat caaag                      105


<210>  1060
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1060
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctggagag aaatccgata aataagaagc atcaaag                    107


<210>  1061
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1061
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ataatccgat aaataagaag catcaaag                   108


<210>  1062
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1062
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1063
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1063
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcattattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1064
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1064
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1065
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1065
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  1066
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1066
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tattgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1067
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1067
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1068
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1068
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1069
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1069
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1070
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1070
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  1071
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1071
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag caatccgata aataagaagc atcaaag                    107


<210>  1072
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1072
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat gaataagaag catcaaag                   108


<210>  1073
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1073
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaagcgat aaataagaag catcaaag                   108


<210>  1074
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1074
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1075
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1075
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1076
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1076
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gatccgataa ataagaagca tcaaag                     106


<210>  1077
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1077
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1078
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1078
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  1079
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1079
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1080
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1080
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcacgata aataagaagc atcaaag                    107


<210>  1081
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1081
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgtttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1082
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1082
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1083
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1083
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  1084
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1084
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggattt ctctccgata aataagaagc atcaaag                    107


<210>  1085
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1085
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  1086
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1086
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1087
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1087
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1088
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1088
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1089
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1089
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taaatccgat aaataagaag catcaaag                   108


<210>  1090
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1090
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1091
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1091
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1092
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1092
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1093
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1093
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1094
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1094
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1095
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1095
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1096
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1096
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1097
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1097
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1098
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1098
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agccttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1099
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1099
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1100
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1100
actggcgctt ttatctcatt actttagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1101
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1101
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1102
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1102
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga tccgataaat aagaagcatc aaag                       104


<210>  1103
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1103
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1104
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1104
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaggaa atccgataaa taagaagcat caaag                      105


<210>  1105
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1105
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1106
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1106
tacggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1107
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1107
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1108
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1108
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1109
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1109
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggcg agaaatccga taaataagaa gcatcaaag                  109


<210>  1110
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1110
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaacgataaa taagaagcat caaag                      105


<210>  1111
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1111
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1112
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1112
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1113
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1113
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1114
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1114
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag atccgataaa taagaagcat caaag                      105


<210>  1115
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1115
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1116
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1116
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1117
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1117
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ctcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1118
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1118
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  1119
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1119
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  1120
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1120
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tctagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1121
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1121
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag agaaatccga taaataagaa gcatcaaag                  109


<210>  1122
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1122
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1123
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1123
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1124
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1124
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1125
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1125
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1126
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1126
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  1127
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1127
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggat ttctctccga taaataagaa gcatcaaag                  109


<210>  1128
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1128
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1129
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1129
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1130
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1130
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1131
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1131
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1132
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1132
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag agaaatccga taaataagaa gcatcaaag                  109


<210>  1133
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1133
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  1134
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1134
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  1135
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1135
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaccgataa ataagaagca tcaaag                     106


<210>  1136
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1136
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1137
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1137
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgta aataagaagc atcaaag                    107


<210>  1138
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1138
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag caaatccgat aaataagaag catcaaag                   108


<210>  1139
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1139
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga ttccgataaa taagaagcat caaag                      105


<210>  1140
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1140
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1141
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1141
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1142
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1142
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  1143
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1143
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  1144
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1144
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1145
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1145
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  1146
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1146
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1147
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1147
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctgata aataagaagc atcaaag                    107


<210>  1148
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1148
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1149
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1149
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1150
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1150
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  1151
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1151
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1152
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1152
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1153
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1153
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1154
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1154
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaacgataa ataagaagca tcaaag                     106


<210>  1155
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1155
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1156
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1156
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1157
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1157
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1158
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1158
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat ccggagagaa atccgataaa taagaagcat caaag                      105


<210>  1159
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1159
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1160
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1160
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1161
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1161
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1162
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1162
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1163
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1163
tactggcgct tttatctaca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1164
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1164
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1165
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1165
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgaa taaataagaa gcatcaaag                  109


<210>  1166
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1166
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1167
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1167
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taggagagaa atccgataaa taagaagcat caaag                      105


<210>  1168
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1168
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1169
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1169
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1170
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1170
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1171
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1171
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1172
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1172
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt aatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1173
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1173
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1174
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1174
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1175
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1175
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcagag aaatccgata aataagaagc atcaaag                    107


<210>  1176
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1176
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1177
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1177
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  1178
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1178
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1179
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1179
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1180
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1180
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ttccgataaa taagaagcat caaag                      105


<210>  1181
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1181
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1182
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1182
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgataaat aagaagcatc aaag                       104


<210>  1183
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1183
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1184
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1184
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1185
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1185
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1186
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1186
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1187
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1187
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agatccgata aataagaagc atcaaag                    107


<210>  1188
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1188
actggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1189
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1189
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtgaga aatccgataa ataagaagca tcaaag                     106


<210>  1190
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1190
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1191
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1191
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgag aaatccgata aataagaagc atcaaag                    107


<210>  1192
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1192
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1193
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1193
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  1194
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1194
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1195
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1195
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatagaga gaaatccgat aaataagaag catcaaag                   108


<210>  1196
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1196
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaataccga taaataagaa gcatcaaag                  109


<210>  1197
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1197
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1198
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1198
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1199
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1199
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1200
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1200
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1201
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1201
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccat aaataagaag catcaaag                   108


<210>  1202
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1202
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1203
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1203
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1204
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1204
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1205
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1205
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1206
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1206
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  1207
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1207
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg aataagaagc atcaaag                    107


<210>  1208
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1208
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1209
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1209
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1210
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1210
ctggcgcttt tatcttcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1211
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1211
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1212
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1212
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1213
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1213
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1214
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1214
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1215
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1215
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1216
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1216
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttgtatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1217
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1217
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaccgataaa taagaagcat caaag                      105


<210>  1218
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1218
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1219
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1219
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1220
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1220
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1221
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1221
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1222
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1222
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag caaatccgat aaataagaag catcaaag                   108


<210>  1223
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1223
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1224
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1224
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1225
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1225
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1226
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1226
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1227
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1227
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  1228
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1228
tactggcgct tttatctcat tactttgctc attactttga gagccatcac cagcgactat       60

gtcgtatggg taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag      120


<210>  1229
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1229
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  1230
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1230
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgcgataa ataagaagca tcaaag                     106


<210>  1231
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1231
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1232
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1232
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1233
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1233
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1234
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1234
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1235
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1235
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1236
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1236
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg ataagaagca tcaaag                     106


<210>  1237
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1237
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  1238
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1238
cctggcgctt ttaatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1239
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1239
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1240
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1240
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1241
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1241
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1242
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1242
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa agcatcaaag                 110


<210>  1243
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1243
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga gtaaataaga agcatcaaag                 110


<210>  1244
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1244
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1245
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1245
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1246
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1246
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata tccgataaat aagaagcatc aaag                       104


<210>  1247
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1247
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagag aaatccgata aataagaagc atcaaag                    107


<210>  1248
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1248
tcactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1249
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1249
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1250
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1250
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1251
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1251
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1252
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1252
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1253
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1253
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1254
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1254
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  1255
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1255
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1256
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1256
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1257
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1257
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1258
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1258
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  1259
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1259
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gagaaatccg ataaataaga agcatcaaag                 110


<210>  1260
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1260
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  1261
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1261
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgg ataaataaga agcatcaaag                 110


<210>  1262
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1262
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1263
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1263
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  1264
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1264
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gaatccgata aataagaagc atcaaag                    107


<210>  1265
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1265
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  1266
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1266
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1267
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1267
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1268
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1268
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1269
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1269
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1270
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1270
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  1271
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1271
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1272
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1272
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1273
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1273
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggattt ctctccgata aataagaagc atcaaag                    107


<210>  1274
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1274
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1275
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1275
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1276
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1276
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1277
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1277
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1278
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1278
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1279
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1279
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1280
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1280
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1281
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1281
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcattattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1282
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1282
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga atccgataaa taagaagcat caaag                      105


<210>  1283
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1283
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  1284
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1284
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1285
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1285
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1286
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1286
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gattccgata aataagaagc atcaaag                    107


<210>  1287
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1287
ctggcgcttt tattctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1288
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1288
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1289
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1289
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1290
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1290
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1291
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1291
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1292
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1292
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  1293
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1293
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1294
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1294
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  1295
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1295
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1296
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1296
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1297
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1297
tactggcgct tttatctaca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1298
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1298
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1299
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1299
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1300
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1300
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctgat aaataagaag catcaaag                   108


<210>  1301
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1301
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1302
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1302
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1303
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1303
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1304
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1304
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1305
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1305
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1306
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1306
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1307
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1307
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1308
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1308
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1309
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1309
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1310
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1310
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  1311
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1311
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1312
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1312
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatatccgat aaataagaag catcaaag                   108


<210>  1313
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1313
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1314
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1314
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1315
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1315
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1316
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1316
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1317
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1317
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1318
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1318
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1319
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1319
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1320
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1320
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1321
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1321
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1322
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1322
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1323
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1323
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1324
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1324
tctggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1325
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1325
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa agcatcaaag                 110


<210>  1326
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1326
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1327
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1327
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1328
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1328
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agataatccg ataaataaga agcatcaaag                 110


<210>  1329
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1329
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1330
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1330
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1331
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1331
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcta aataagaagc atcaaag                    107


<210>  1332
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1332
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1333
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1333
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1334
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1334
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1335
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1335
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1336
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1336
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1337
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1337
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1338
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1338
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1339
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1339
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1340
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1340
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1341
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1341
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1342
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1342
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agaatccgat aaataagaag catcaaag                   108


<210>  1343
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1343
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggag aaatccgata aataagaagc atcaaag                    107


<210>  1344
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1344
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1345
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1345
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1346
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1346
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1347
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1347
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1348
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1348
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  1349
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1349
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggaagaaa tccgataaat aagaagcatc aaag                       104


<210>  1350
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1350
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  1351
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1351
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1352
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1352
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1353
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1353
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  1354
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1354
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga tatccgataa ataagaagca tcaaag                     106


<210>  1355
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1355
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1356
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1356
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatttagag aaatccgata aataagaagc atcaaag                    107


<210>  1357
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1357
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1358
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1358
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1359
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1359
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atagagagaa atccgataaa taagaagcat caaag                      105


<210>  1360
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1360
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1361
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1361
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1362
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1362
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  1363
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1363
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1364
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1364
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1365
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1365
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1366
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1366
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1367
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1367
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1368
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1368
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccggtaa ataagaagca tcaaag                     106


<210>  1369
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1369
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1370
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1370
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  1371
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1371
tcggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  1372
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1372
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1373
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1373
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1374
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1374
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg agaaatccga taaataagaa gcatcaaag                  109


<210>  1375
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1375
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgatattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1376
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1376
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  1377
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1377
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatt aaataagaag catcaaag                   108


<210>  1378
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1378
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1379
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1379
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1380
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1380
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  1381
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1381
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agaatccgat aaataagaag catcaaag                   108


<210>  1382
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1382
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1383
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1383
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1384
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1384
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agcatccgat aaataagaag catcaaag                   108


<210>  1385
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1385
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1386
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1386
gctggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1387
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1387
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgta taaataagaa gcatcaaag                  109


<210>  1388
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1388
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga taatccgata aataagaagc atcaaag                    107


<210>  1389
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1389
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1390
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1390
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  1391
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1391
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1392
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1392
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1393
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1393
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga gtccgataaa taagaagcat caaag                      105


<210>  1394
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1394
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  1395
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1395
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaatccgat aaataagaag catcaaag                   108


<210>  1396
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1396
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  1397
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1397
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  1398
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1398
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaatccg ataaataaga agcatcaaag                 110


<210>  1399
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1399
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1400
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1400
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1401
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1401
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1402
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1402
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  1403
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1403
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1404
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1404
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  1405
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1405
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1406
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1406
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1407
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1407
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1408
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1408
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagtaagc atcaaag                    107


<210>  1409
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1409
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  1410
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1410
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1411
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1411
tctggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1412
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1412
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaaag catcaaag                   108


<210>  1413
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1413
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcggtat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1414
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1414
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1415
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1415
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagtaa atccgataaa taagaagcat caaag                      105


<210>  1416
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1416
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  1417
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1417
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1418
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1418
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1419
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1419
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1420
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1420
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattgataa ataagaagca tcaaag                     106


<210>  1421
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1421
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggga aatccgataa ataagaagca tcaaag                     106


<210>  1422
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1422
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt ctcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1423
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1423
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1424
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1424
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1425
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1425
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag acaatccgat aaataagaag catcaaag                   108


<210>  1426
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1426
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  1427
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1427
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  1428
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1428
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtga gaaatccgat aaataagaag catcaaag                   108


<210>  1429
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1429
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1430
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1430
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1431
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1431
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1432
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1432
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1433
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1433
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  1434
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1434
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1435
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1435
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagctttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1436
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1436
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggat aaataagaag catcaaag                   108


<210>  1437
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1437
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1438
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1438
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aacatccgat aaataagaag catcaaag                   108


<210>  1439
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1439
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggat aaataagaag catcaaag                   108


<210>  1440
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1440
taaggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1441
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1441
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag acaatccgat aaataagaag catcaaag                   108


<210>  1442
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1442
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1443
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1443
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaaag catcaaag                   108


<210>  1444
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1444
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgaa atccgataaa taagaagcat caaag                      105


<210>  1445
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1445
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1446
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1446
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1447
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1447
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgatattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1448
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1448
ctggcgcttt tatctctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1449
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1449
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttgtatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1450
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1450
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata tataagaagc atcaaag                    107


<210>  1451
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1451
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1452
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1452
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1453
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1453
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ataatccgat aaataagaag catcaaag                   108


<210>  1454
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1454
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgt aaataagaag catcaaag                   108


<210>  1455
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1455
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga aaataagaag catcaaag                   108


<210>  1456
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1456
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccggaaa taagaagcat caaag                      105


<210>  1457
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1457
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggggaga aatccgataa ataagaagca tcaaag                     106


<210>  1458
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1458
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1459
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1459
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1460
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1460
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1461
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1461
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1462
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1462
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  1463
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1463
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga caatccgata aataagaagc atcaaag                    107


<210>  1464
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1464
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  1465
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1465
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  1466
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1466
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1467
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1467
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgggagaaat ccgataaata agaagcatca aag                        103


<210>  1468
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1468
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  1469
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1469
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aggatccgat aaataagaag catcaaag                   108


<210>  1470
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1470
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1471
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1471
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1472
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1472
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga accgataaat aagaagcatc aaag                       104


<210>  1473
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1473
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1474
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1474
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  1475
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1475
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1476
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1476
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1477
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1477
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1478
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1478
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1479
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1479
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1480
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1480
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1481
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1481
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1482
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1482
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1483
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1483
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tcatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1484
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1484
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1485
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1485
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1486
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1486
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1487
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1487
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1488
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1488
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1489
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1489
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttatttt cggagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1490
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1490
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1491
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1491
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taatccgata aataagaagc atcaaag                    107


<210>  1492
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1492
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1493
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1493
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1494
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1494
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1495
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1495
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1496
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1496
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaccgataaa taagaagcat caaag                      105


<210>  1497
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1497
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcgat aaataagaag catcaaag                   108


<210>  1498
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1498
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1499
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1499
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg aataagaagc atcaaag                    107


<210>  1500
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1500
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1501
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1501
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1502
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1502
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1503
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1503
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  1504
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1504
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1505
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1505
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccct aaataagaag catcaaag                   108


<210>  1506
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1506
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1507
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1507
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  1508
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1508
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1509
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1509
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  1510
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1510
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1511
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1511
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag attccgataa ataagaagca tcaaag                     106


<210>  1512
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1512
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1513
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1513
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1514
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1514
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1515
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1515
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1516
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1516
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  1517
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1517
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaaag catcaaag                   108


<210>  1518
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1518
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  1519
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1519
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaagatccg ataaataaga agcatcaaag                 110


<210>  1520
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1520
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggcagaga aatccgataa ataagaagca tcaaag                     106


<210>  1521
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1521
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1522
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1522
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1523
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1523
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1524
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1524
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgagagaaat ccgataaata agaagcatca aag                        103


<210>  1525
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1525
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1526
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1526
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1527
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1527
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagtccgat aaataagaag catcaaag                   108


<210>  1528
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1528
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1529
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1529
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1530
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1530
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1531
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1531
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1532
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1532
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1533
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1533
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1534
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1534
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1535
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1535
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  1536
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1536
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1537
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1537
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1538
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1538
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1539
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1539
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1540
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1540
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1541
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1541
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1542
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1542
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  1543
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1543
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1544
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1544
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agaatccgat aaataagaag catcaaag                   108


<210>  1545
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1545
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  1546
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1546
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1547
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1547
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1548
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1548
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  1549
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1549
gctggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1550
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1550
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1551
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1551
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttctcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1552
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1552
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  1553
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1553
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaacgataaa taagaagcat caaag                      105


<210>  1554
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1554
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctgata aataagaagc atcaaag                    107


<210>  1555
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1555
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1556
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1556
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  1557
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1557
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  1558
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1558
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa gaaatccgat aaataagaag catcaaag                   108


<210>  1559
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1559
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1560
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1560
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  1561
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1561
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  1562
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1562
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1563
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1563
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1564
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1564
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1565
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1565
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1566
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1566
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcggtat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1567
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1567
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1568
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1568
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1569
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1569
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  1570
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1570
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggtg agaaatccga taaataagaa gcatcaaag                  109


<210>  1571
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1571
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1572
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1572
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  1573
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1573
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  1574
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1574
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg ataagaagca tcaaag                     106


<210>  1575
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1575
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gctttattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1576
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1576
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctgagaa atccgataaa taagaagcat caaag                      105


<210>  1577
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1577
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1578
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1578
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1579
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1579
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1580
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1580
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgatattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1581
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1581
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1582
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1582
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgg ataaataaga agcatcaaag                 110


<210>  1583
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1583
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1584
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1584
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1585
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1585
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1586
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1586
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1587
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1587
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1588
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1588
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1589
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1589
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga taaataagag agcatcaaag                 110


<210>  1590
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1590
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1591
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1591
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1592
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1592
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1593
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1593
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  1594
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1594
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccct aaataagaag catcaaag                   108


<210>  1595
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1595
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcattattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1596
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1596
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1597
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1597
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1598
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1598
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1599
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1599
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  1600
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1600
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  1601
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1601
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcgaga aatccgataa ataagaagca tcaaag                     106


<210>  1602
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1602
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1603
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1603
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1604
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1604
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  1605
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1605
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1606
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1606
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  1607
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1607
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1608
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1608
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1609
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1609
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agacaatccg ataaataaga agcatcaaag                 110


<210>  1610
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1610
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagaaat ccgataaata agaagcatca aag                        103


<210>  1611
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1611
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1612
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1612
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1613
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1613
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1614
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1614
tacggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1615
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1615
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1616
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1616
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagtaag catcaaag                   108


<210>  1617
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1617
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1618
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1618
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgga aataagaagc atcaaag                    107


<210>  1619
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1619
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1620
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1620
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcta aataagaagc atcaaag                    107


<210>  1621
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1621
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1622
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1622
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggcg agaaatccga taaataagaa gcatcaaag                  109


<210>  1623
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1623
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1624
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1624
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1625
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1625
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1626
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1626
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1627
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1627
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  1628
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1628
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1629
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1629
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1630
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1630
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcga gaaatccgat aaataagaag catcaaag                   108


<210>  1631
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1631
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  1632
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1632
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1633
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1633
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1634
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1634
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattc tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1635
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1635
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1636
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1636
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aagtccgata aataagaagc atcaaag                    107


<210>  1637
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1637
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gaaatccgat aaataagaag catcaaag                   108


<210>  1638
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1638
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1639
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1639
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1640
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1640
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaca atccgataaa taagaagcat caaag                      105


<210>  1641
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1641
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1642
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1642
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1643
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1643
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1644
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1644
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1645
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1645
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1646
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1646
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1647
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1647
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1648
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1648
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  1649
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1649
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1650
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1650
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgagagaaat ccgataaata agaagcatca aag                        103


<210>  1651
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1651
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1652
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1652
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1653
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1653
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagataaat aagaagcatc aaag                       104


<210>  1654
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1654
tcactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1655
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1655
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1656
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1656
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1657
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1657
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1658
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1658
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttatta tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1659
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1659
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1660
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1660
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgcgataa ataagaagca tcaaag                     106


<210>  1661
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1661
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  1662
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1662
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatagataa ataagaagca tcaaag                     106


<210>  1663
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1663
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1664
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1664
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1665
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1665
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1666
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1666
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1667
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1667
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  1668
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1668
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1669
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1669
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1670
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1670
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1671
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1671
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1672
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1672
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgggagaaat ccgataaata agaagcatca aag                        103


<210>  1673
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1673
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1674
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1674
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1675
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1675
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1676
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1676
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggatgaa atccgataaa taagaagcat caaag                      105


<210>  1677
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1677
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1678
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1678
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1679
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1679
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  1680
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1680
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1681
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1681
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1682
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1682
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1683
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1683
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  1684
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1684
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  1685
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1685
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1686
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1686
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1687
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1687
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  1688
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1688
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  1689
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1689
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1690
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1690
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1691
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1691
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1692
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1692
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1693
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1693
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1694
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1694
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1695
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1695
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1696
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1696
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1697
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1697
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggatga aatccgataa ataagaagca tcaaag                     106


<210>  1698
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1698
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  1699
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1699
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  1700
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1700
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggaggaaa tccgataaat aagaagcatc aaag                       104


<210>  1701
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1701
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatacgata aataagaagc atcaaag                    107


<210>  1702
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1702
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1703
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1703
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1704
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1704
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtcag aaatccgata aataagaagc atcaaag                    107


<210>  1705
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1705
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  1706
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1706
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaatccgat aaataagaag catcaaag                   108


<210>  1707
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1707
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  1708
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1708
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtagag aaatccgata aataagaagc atcaaag                    107


<210>  1709
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1709
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1710
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1710
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1711
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1711
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctgata aataagaagc atcaaag                    107


<210>  1712
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1712
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1713
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1713
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1714
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1714
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1715
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1715
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cggagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1716
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1716
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagta agcatcaaag                 110


<210>  1717
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1717
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1718
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1718
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1719
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1719
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1720
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1720
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1721
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1721
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  1722
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1722
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1723
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1723
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  1724
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1724
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  1725
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1725
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1726
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1726
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1727
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1727
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1728
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1728
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1729
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1729
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  1730
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1730
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaagcgata aataagaagc atcaaag                    107


<210>  1731
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1731
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1732
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1732
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  1733
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1733
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  1734
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1734
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1735
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1735
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1736
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1736
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1737
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1737
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1738
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1738
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1739
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1739
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1740
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1740
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1741
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1741
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1742
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1742
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1743
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1743
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1744
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1744
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaaacgata aataagaagc atcaaag                    107


<210>  1745
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1745
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcctgata aataagaagc atcaaag                    107


<210>  1746
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1746
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1747
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1747
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1748
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1748
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1749
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1749
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcagag aaatccgata aataagaagc atcaaag                    107


<210>  1750
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1750
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1751
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1751
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1752
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1752
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag atccgataaa taagaagcat caaag                      105


<210>  1753
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1753
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1754
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1754
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1755
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1755
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1756
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1756
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1757
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1757
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  1758
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1758
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1759
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1759
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1760
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1760
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgt aaataagaag catcaaag                   108


<210>  1761
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1761
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1762
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1762
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1763
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1763
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1764
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1764
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1765
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1765
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1766
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1766
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgag taaataagaa gcatcaaag                  109


<210>  1767
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1767
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1768
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1768
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1769
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1769
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttataaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1770
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1770
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1771
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1771
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1772
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1772
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1773
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1773
cctggcgctt ttatctatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1774
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1774
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  1775
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1775
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1776
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1776
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaaa gaaatccgat aaataagaag catcaaag                   108


<210>  1777
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1777
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1778
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1778
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1779
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1779
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1780
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1780
cctggcgctt ttatctacat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1781
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1781
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1782
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1782
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1783
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1783
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1784
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1784
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1785
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1785
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1786
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1786
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1787
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1787
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1788
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1788
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1789
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1789
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1790
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1790
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagatag catcaaag                   108


<210>  1791
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1791
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1792
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1792
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1793
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1793
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1794
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1794
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1795
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1795
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccat aaataagaag catcaaag                   108


<210>  1796
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1796
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1797
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1797
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1798
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1798
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1799
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1799
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatggat aaataagaag catcaaag                   108


<210>  1800
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1800
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccct aaataagaag catcaaag                   108


<210>  1801
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1801
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  1802
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1802
cctggcgctt ttatctcaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1803
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1803
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccat aaataagaag catcaaag                   108


<210>  1804
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1804
tactggcgct tttatttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1805
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1805
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  1806
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1806
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1807
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1807
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1808
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1808
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1809
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1809
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1810
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1810
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1811
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1811
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga gtaaataaga agcatcaaag                 110


<210>  1812
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1812
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  1813
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1813
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1814
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1814
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1815
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1815
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1816
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1816
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  1817
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1817
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1818
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1818
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1819
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1819
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1820
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1820
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1821
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1821
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1822
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1822
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  1823
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1823
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1824
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1824
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  1825
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1825
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agatccgata aataagaagc atcaaag                    107


<210>  1826
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1826
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagagagc atcaaag                    107


<210>  1827
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1827
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1828
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1828
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1829
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1829
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1830
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1830
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1831
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1831
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1832
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1832
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagag agcatcaaag                 110


<210>  1833
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1833
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  1834
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1834
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1835
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1835
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaaatccg ataaataaga agcatcaaag                 110


<210>  1836
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1836
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1837
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1837
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1838
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1838
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  1839
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1839
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1840
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1840
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1841
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1841
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1842
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1842
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1843
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1843
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1844
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1844
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  1845
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1845
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  1846
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1846
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1847
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1847
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcagata aataagaagc atcaaag                    107


<210>  1848
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1848
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1849
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1849
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1850
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1850
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gagaaatccg ataaataaga agcatcaaag                 110


<210>  1851
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1851
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1852
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1852
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aggatccgat aaataagaag catcaaag                   108


<210>  1853
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1853
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1854
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1854
actggcgctt ttatctcgat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1855
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1855
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1856
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1856
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggcg agaaatccga taaataagaa gcatcaaag                  109


<210>  1857
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1857
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1858
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1858
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  1859
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1859
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1860
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1860
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atggagagaa atccgataaa taagaagcat caaag                      105


<210>  1861
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1861
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1862
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1862
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  1863
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1863
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag aggatccgat aaataagaag catcaaag                   108


<210>  1864
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1864
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1865
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1865
tactggcgct tttaatcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1866
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1866
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcgataa ataagaagca tcaaag                     106


<210>  1867
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1867
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggat aaataagaag catcaaag                   108


<210>  1868
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1868
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1869
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1869
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1870
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1870
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgagt aaataagaag catcaaag                   108


<210>  1871
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1871
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  1872
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1872
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcccgat aaataagaag catcaaag                   108


<210>  1873
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1873
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1874
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1874
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttatta tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1875
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1875
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1876
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1876
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1877
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1877
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1878
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1878
actggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1879
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1879
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggga gaaatccgat aaataagaag catcaaag                   108


<210>  1880
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1880
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1881
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1881
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  1882
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1882
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag aaatccgata aataagaagc atcaaag                    107


<210>  1883
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1883
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1884
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1884
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  1885
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1885
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  1886
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1886
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1887
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1887
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1888
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1888
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  1889
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1889
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1890
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1890
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1891
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1891
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga ttatccgata aataagaagc atcaaag                    107


<210>  1892
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1892
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1893
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1893
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1894
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1894
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1895
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1895
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1896
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1896
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1897
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1897
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1898
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1898
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  1899
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1899
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggggaaa tccgataaat aagaagcatc aaag                       104


<210>  1900
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1900
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1901
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1901
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1902
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1902
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagta agcatcaaag                 110


<210>  1903
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1903
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1904
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1904
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1905
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1905
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1906
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1906
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1907
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1907
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgagta aataagaagc atcaaag                    107


<210>  1908
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1908
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag taaatccgat aaataagaag catcaaag                   108


<210>  1909
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1909
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggtg agaaatccga taaataagaa gcatcaaag                  109


<210>  1910
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1910
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1911
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1911
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1912
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1912
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctgagag aaatccgata aataagaagc atcaaag                    107


<210>  1913
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1913
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1914
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1914
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1915
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1915
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1916
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1916
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga tagtaagaag catcaaag                   108


<210>  1917
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1917
cctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1918
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1918
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1919
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1919
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  1920
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1920
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1921
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1921
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1922
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1922
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  1923
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1923
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta gtcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1924
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1924
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1925
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1925
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1926
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1926
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgaa atccgataaa taagaagcat caaag                      105


<210>  1927
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1927
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1928
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1928
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1929
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1929
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1930
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1930
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaaatccgat aaataagaag catcaaag                   108


<210>  1931
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1931
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gaaatccgat aaataagaag catcaaag                   108


<210>  1932
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1932
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1933
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1933
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1934
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1934
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  1935
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1935
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1936
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1936
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1937
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1937
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1938
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1938
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  1939
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1939
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  1940
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1940
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1941
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1941
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1942
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1942
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1943
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1943
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1944
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1944
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  1945
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1945
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1946
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1946
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1947
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1947
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1948
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1948
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1949
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1949
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1950
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1950
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1951
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1951
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1952
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1952
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1953
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1953
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1954
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1954
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  1955
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1955
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggac gaaatccgat aaataagaag catcaaag                   108


<210>  1956
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1956
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1957
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1957
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagag agcatcaaag                 110


<210>  1958
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1958
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1959
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1959
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1960
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1960
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  1961
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1961
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggatga aatccgataa ataagaagca tcaaag                     106


<210>  1962
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1962
ctggcgcttt tatcctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1963
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1963
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1964
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1964
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1965
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1965
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag agaaatccga taaataagaa gcatcaaag                  109


<210>  1966
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1966
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  1967
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1967
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1968
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1968
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  1969
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1969
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  1970
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1970
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga caatccgata aataagaagc atcaaag                    107


<210>  1971
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1971
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1972
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1972
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  1973
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1973
tactggcgct tttatcttat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1974
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1974
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatgccgata aataagaagc atcaaag                    107


<210>  1975
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1975
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1976
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1976
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa agcatcaaag                 110


<210>  1977
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1977
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1978
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1978
cctggcgctt ttatcatcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1979
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1979
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1980
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1980
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1981
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1981
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1982
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1982
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1983
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1983
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  1984
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1984
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1985
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1985
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1986
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1986
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1987
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1987
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaatccgat aaataagaag catcaaag                   108


<210>  1988
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1988
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1989
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1989
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1990
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1990
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1991
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1991
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatacgat aaataagaag catcaaag                   108


<210>  1992
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1992
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1993
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1993
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1994
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1994
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1995
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1995
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat caagagaaat ccgataaata agaagcatca aag                        103


<210>  1996
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1996
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  1997
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1997
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1998
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1998
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1999
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1999
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2000
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2000
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgaat aaataagaag catcaaag                   108


<210>  2001
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2001
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  2002
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2002
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2003
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2003
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2004
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2004
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2005
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2005
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2006
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2006
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2007
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2007
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2008
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2008
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2009
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2009
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2010
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2010
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2011
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2011
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2012
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2012
gctggcgctt ttatctcgat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2013
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2013
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgta aataagaagc atcaaag                    107


<210>  2014
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2014
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2015
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2015
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atccgtaaat aagaagcatc aaag                       104


<210>  2016
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2016
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2017
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2017
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2018
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2018
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcttgag aaatccgata aataagaagc atcaaag                    107


<210>  2019
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2019
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2020
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2020
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaaag catcaaag                   108


<210>  2021
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2021
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2022
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2022
tactggcgct tttatctttt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2023
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2023
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  2024
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2024
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2025
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2025
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2026
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2026
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  2027
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2027
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2028
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2028
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gaatccgata aataagaagc atcaaag                    107


<210>  2029
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2029
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2030
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2030
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  2031
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2031
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2032
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2032
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2033
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2033
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttctcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2034
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2034
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2035
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2035
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggatg aaatccgata aataagaagc atcaaag                    107


<210>  2036
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2036
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2037
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2037
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2038
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2038
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2039
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2039
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattcgata aataagaagc atcaaag                    107


<210>  2040
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2040
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  2041
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2041
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2042
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2042
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga tagtaagaag catcaaag                   108


<210>  2043
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2043
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2044
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2044
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2045
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2045
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaataccga taaataagaa gcatcaaag                  109


<210>  2046
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2046
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2047
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2047
tactggccct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2048
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2048
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  2049
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2049
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2050
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2050
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaccgat aaataagaag catcaaag                   108


<210>  2051
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2051
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2052
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2052
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatatccgat aaataagaag catcaaag                   108


<210>  2053
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2053
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2054
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2054
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2055
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2055
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatagata aataagaagc atcaaag                    107


<210>  2056
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2056
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2057
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2057
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2058
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2058
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2059
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2059
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2060
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2060
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2061
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2061
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2062
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2062
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2063
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2063
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2064
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2064
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2065
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2065
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2066
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2066
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2067
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2067
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2068
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2068
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2069
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2069
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2070
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2070
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2071
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2071
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2072
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2072
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2073
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2073
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2074
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2074
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2075
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2075
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2076
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2076
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2077
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2077
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2078
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2078
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2079
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2079
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2080
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2080
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2081
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2081
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2082
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2082
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  2083
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2083
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2084
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2084
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2085
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2085
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2086
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2086
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2087
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2087
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2088
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2088
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2089
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2089
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2090
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2090
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2091
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2091
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2092
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2092
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2093
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2093
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2094
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2094
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2095
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2095
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagctttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2096
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2096
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2097
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2097
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2098
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2098
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2099
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2099
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2100
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2100
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tataggagag aaatccgata aataagaagc atcaaag                    107


<210>  2101
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2101
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2102
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2102
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgacgcgucc ucgagcagaa gcaucaaag                              99


<210>  2103
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2103
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgcuccguuc gagcagaagc aucaaag                                97


<210>  2104
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2104
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcccu cuucggaggg aagcaucaaa g                                      91


<210>  2105
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2105
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcagga guuucuaugg aaacccugaa gcaucaaag                              99


<210>  2106
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2106
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2107
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2107
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcg cuugcgcaga agcaucaaag                                        90


<210>  2108
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2108
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2109
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2109
uacuggcgcu uuuaucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2110
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2110
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga cuucgguccg auaaauaaga agcaucaaag                 110


<210>  2111
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2111
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcacau gaggauuacc caugugaagc aucaaag                                97


<210>  2112
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2112
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucgugaga aauccgauaa auaagaagca ucaaag                     106


<210>  2113
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2113
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugca ugucuaagac agcagaagca ucaaag                                 96


<210>  2114
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2114
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccga agcaucaaag                                        90


<210>  2115
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2115
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaauc cauugcacuc cggauugaag caucaaag                               98


<210>  2116
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2116
uacuggcgcu uuucucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2117
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2117
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2118
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2118
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cguuugcggc uacgagcaga agcaucaaag                            100


<210>  2119
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2119
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagag auaaauaaga agcaucaaag                            100


<210>  2120
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2120
uacggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2121
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2121
uacuggcgcc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2122
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2122
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaucggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2123
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2123
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2124
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2124
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagaa auccgauaaa uaagaagcau caaag                      105


<210>  2125
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2125
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggagagaaau ccgauaaaua agaagcauca aag                        103


<210>  2126
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2126
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gagauaaaua agaagcauca aag                        103


<210>  2127
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2127
uacuggcgcu uuuaucucau uacuuuggag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag aguauccgau aaauaagaag caucaaag                   108


<210>  2128
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2128
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2129
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2129
agcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cggagagaaa ugccgauaaa uaagaagcau caaag                      105


<210>  2130
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2130
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaauaagaa gcaucaaag                  109


<210>  2131
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2131
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uguaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2132
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2132
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggacuucggu ccgauaaaua agcgcaucaa ag                         102


<210>  2133
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2133
uacuggcgcu uuucucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2134
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2134
guggcgcuuu uaucucauua cuuugagagc caucaccagc gacuaugucg uauggguaaa       60

gcgcuuauuu aucggagaga aauccgauaa auaagaagca ucaaag                     106


<210>  2135
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2135
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaccuuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag                 110


<210>  2136
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2136
gauggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2137
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2137
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaagaagca ucaaag                     106


<210>  2138
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2138
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaucuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2139
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2139
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aaggcuuauu uaucggagag aaauccgaua aaaagaagca ucaaag                     106


<210>  2140
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2140
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaaagaagc aucaaag                    107


<210>  2141
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2141
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2142
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2142
cggcgcuuuu cucgcauuac uuugagagcc aucaccagcg acuaugucgu auggguaaag       60

cgcuuauugu aucgagagau aaauaagaag caucaaag                               98


<210>  2143
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2143
cacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2144
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2144
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau guaucggcuu cggccgauac auaagaagca ucaaag                     106


<210>  2145
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2145
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uguaucggcu ucggccgaua cauaagaagc aucaaag                    107


<210>  2146
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2146
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggug       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2147
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2147
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaag                                                                    64


<210>  2148
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2148
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

ag                                                                      62


<210>  2149
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2149
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

agcgcuuauu uaucggcuuc ggccgauaaa uaagaagcau caaag                      105


<210>  2150
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2150
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuaca cugggaucgc ugaauuagag aucggcgucc uuucauucua uauacuuugg      120

aguuuuaaaa ugucucuaag uacagaagca ucaaag                                156


<210>  2151
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2151
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuucggucgu auggguaaag       60

cgcuuauuua ucggcuucgg ccgauaaaua agaagcauca aag                        103


<210>  2152
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2152
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau uuaucggcuu cggccgauaa auaagaagca ucaaag                     106


<210>  2153
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2153
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2154
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2154
uacuggcgcu uuuaucucau uacuuugaga gccaugcucc accagcgacu augucguaug       60

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              112


<210>  2155
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2155
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgggguu aggguuaggg uuagggaagc aucaaag                                97


<210>  2156
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2156
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcggaggg agggagggag agggaaagca ucaaag                                 96


<210>  2157
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2157
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcguuggg uuaggguuag gguuagggaa aagcaucaaa g                          101


<210>  2158
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2158
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccgg aagcaucaaa g                                      91


<210>  2159
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2159
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccugc ucaguacgag aggaaccgca ggaagcauca aag                        103


<210>  2160
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2160
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2161
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2161
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2162
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2162
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2163
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2163
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2164
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2164
uacuggcgcc uuuaucugca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2165
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2165
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2166
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2166
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2167
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2167
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2168
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2168
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2169
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2169
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2170
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2170
uacuggcgcc uuuaucauca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2171
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2171
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg ccggcauggu      120

cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgucc ccucgguaau      180

ggcgaauggg accc                                                        194


<210>  2172
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2172
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2173
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2173
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga aauccgauaa auaagaagca ucaaag                     106


<210>  2174
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2174
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2175
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2175
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccgga cuucgguccg gaagcaucaa ag                                     92


<210>  2176
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2176
uacuggcgcu uuuaucggau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2177
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2177
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2178
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2178
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2179
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2179
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2180
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2180
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gucggcaugg      120

caucuccacc uccucgcggu ccgaccuggg cauccgaagg aggacgcacg uccacucgga      180

uggcuaaggg agagcca                                                     197


<210>  2181
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2181
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggcg caucaaag                                          88


<210>  2182
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2182
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaguu uuggccggca      120

uggucccagc cuccucgcug gcgccggcug ggcaacaugc uucggcaugg cgaaugggac      180

cccggg                                                                 186


<210>  2183
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2183
gauggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2184
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2184
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2185
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2185
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucuuacg gacuucgguc cguaagagca ucaaag                                 96


<210>  2186
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2186
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucggacg accucucggu cguccgagca ucaaag                                 96


<210>  2187
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2187
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc ugucaccgga      120

ugugcuuucc ggucugauga guccgugagg acgaaacagg                            160


<210>  2188
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2188
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2189
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2189
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2190
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2190
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucaggug ggacgaccuc ucggucgucc uaucugagca ucaaag                     106


<210>  2191
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2191
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagga uggccggcau      120

ggucccagcc uccucgcugg cgccggcugg gcaacaccuu cggguggcga augggac         177


<210>  2192
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2192
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2193
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2193
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguacugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2194
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2194
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgugag aaauccgaua aauaagaagc aucaaag                    107


<210>  2195
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2195
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2196
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2196
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2197
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2197
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2198
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2198
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2199
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2199
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2200
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2200
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2201
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2201
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2202
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2202
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2203
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2203
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2204
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2204
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2205
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2205
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2206
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2206
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2207
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2207
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2208
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2208
gauggccggc auggucccag ccuccucgcu ggcgccggcu gggcaacacc uucggguggc       60

gaaugggacu acuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc      120

guauggguaa agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag         177


<210>  2209
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2209
ggccggcaug gucccagccu ccucgcuggc gccggcuggg caacauuccg aggggaccgu       60

ccccucggua auggcgaaug ggacccuacu ggcgcuuuua ucucauuacu uugagagcca      120

ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau      180

aagaagcauc aaag                                                        194


<210>  2210
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2210
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagcgca ucaaag                                 96


<210>  2211
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2211
cgugguuagg gccacguuaa auaguugcuu aagcccuaag cguugaucuu cggaucaggu       60

gcaauacugg cgcuuuuauc ucauuacuuu gagagccauc accagcgacu augucguaug      120

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              172


<210>  2212
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2212
gggucggcau ggcaucucca ccuccucgcg guccgaccug ggcauccgaa ggaggacgca       60

cguccacucg gauggcuaag ggagagccau acuggcgcuu uuaucucauu acuuugagag      120

ccaucaccag cgacuauguc guauggguaa agcgcuuauu uaucggagag aaauccgaua      180

aauaagaagc aucaaag                                                     197


<210>  2213
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2213
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc aguacugaug      120

aguccgugag gacgaaacga guaagcucgu cuacuggcgc uuuuaucuca u               171


<210>  2214
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2214
uacuggcgcc uuuaucucau uacuuuagag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2215
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2215
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgu acuggcgcuu       60

uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu      120

uaucggagag aaauccgaua aauaagaagc aucaaag                               157


<210>  2216
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2216
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugcgca ucaaag                     106


<210>  2217
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2217
uacuggcgcc uuuaucucau uacuuuagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2218
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2218
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagca uuccucagaa      120

aaugacaaac cuguggggcg uaaguagauc uucggaucua ugaucgugca gacguuaaaa      180

ucaggu                                                                 186


<210>  2219
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2219
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucgcgu guagcgaagc a               171


<210>  2220
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2220
cauuccucag aaaaugacaa accugugggg cguaaguaga ucuucggauc uaugaucgug       60

cagacguuaa aaucagguua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2221
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2221
uuuuggccgg caugguccca gccuccucgc uggcgccggc ugggcaacau gcuucggcau       60

ggcgaauggg accccgggua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2222
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2222
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgc guguagcgaa       60

gcauacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2223
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2223
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gagccccgcu      120

gaugaggucg gggagaccga aagggacuuc ggucccuacg gggcuccc                   168


<210>  2224
<211>  144
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2224
ccacccccac caccaccccc acccccacca ccacccuacu ggcgcuuuua ucucauuacu       60

uugagagcca ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa      120

uccgauaaau aagaagcauc aaag                                             144


<210>  2225
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2225
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucg                               157


<210>  2226
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2226
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg ugguuagggc      120

cacguuaaau aguugcuuaa gcccuaagcg uugaucuucg gaucaggugc aa              172


<210>  2227
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2227
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg caauaaagcg      120

guuacaagcc cgcaaaaaua gcagaguaau gucgcgauag cgcggcauua augcagcuuu      180

auug                                                                   184


<210>  2228
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2228
uacuggcgcu uuuaucucau uacuauuauc ucauuacuuu gagagccauc accagcgacu       60

augucguaug gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa      120

ag                                                                     122


<210>  2229
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2229
ggcaauaaag cgguuacaag cccgcaaaaa uagcagagua augucgcgau agcgcggcau       60

uaaugcagcu uuauuguacu ggcgcuuuua ucucauuacu uugagagcca ucaccagcga      120

cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau aagaagcauc      180

aaag                                                                   184


<210>  2230
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2230
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagac ccgcaaggcc      120

gacggcaucc gccgccgcug gugcaagucc agccgccccu ucgggggcgg gcgcucaugg      180

guaac                                                                  185


<210>  2231
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2231
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aag                                                                     63


<210>  2232
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2232
gggagccccg cugaugaggu cggggagacc gaaagggacu ucggucccua cggggcuccc       60

uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua      120

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   168


<210>  2233
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2233
ccaguacuga ugaguccgug aggacgaaac gaguaagcuc gucuacuggc gcuuuuaucu       60

cauuacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2234
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2234
acccgcaagg ccgacggcau ccgccgccgc uggugcaagu ccagccgccc cuucgggggc       60

gggcgcucau ggguaacuac uggcgcuuuu aucucauuac uuugagagcc aucaccagcg      120

acuaugucgu auggguaaag cgcuuauuua ucggagagaa auccgauaaa uaagaagcau      180

caaag                                                                  185


<210>  2235
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2235
ccugucaccg gaugugcuuu ccggucugau gaguccguga ggacgaaaca gguacuggcg       60

cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg uaaagcgcuu      120

auuuaucgga gagaaauccg auaaauaaga agcaucaaag                            160


<210>  2236
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2236
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag                            100


<210>  2237
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2237
guacuggcgc uuuuaucuga uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcuccc ucuucggagg gagcaucaaa g                                      91


<210>  2238
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2238
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2239
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2239
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2240
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2240
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2241
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2241
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2242
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2242
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2243
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2243
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2244
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2244
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2245
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2245
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2246
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2246
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2247
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2247
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2248
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2248
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2249
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2249
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  2250
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2250
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2251
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2251
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2252
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2252
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2253
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2253
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2254
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2254
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2255
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2255
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2256
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2256
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2257
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2257
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2258
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2258
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2259
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2259
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2260
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2260
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2261
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2261
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2262
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2262
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2263
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2263
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2264
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2264
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2265
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2265
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2266
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2266
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2267
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2267
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2268
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2268
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2269
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2269
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2270
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2270
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2271
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2271
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2272
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2272
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2273
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2273
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2274
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2274
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2275
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2275
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2276
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2276
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2277
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2277
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2278
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2278
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2279
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2279
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2280
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2280
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2281
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2281
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagagag catcaaag                   108


<210>  2282
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2282
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2283
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2283
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2284
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2284
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2285
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2285
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2286
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2286
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2287
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2287
cactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2288
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2288
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2289
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2289
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2290
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2290
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2291
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2291
tcactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  2292
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2292
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2293
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2293
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2294
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2294
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2295
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2295
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2296
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2296
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2297
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2297
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2298
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2298
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaagagata aataagaagc atcaaag                    107


<210>  2299
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2299
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg agaaatccga taaataagaa gcatcaaag                  109


<210>  2300
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2300
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2301
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2301
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2302
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2302
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  2303
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2303
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2304
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2304
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2305
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2305
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2306
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2306
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2307
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2307
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2308
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2308
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  2309
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2309
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2310
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2310
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2311
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2311
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2312
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2312
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2313
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2313
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagtaag catcaaag                   108


<210>  2314
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2314
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2315
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2315
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  2316
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2316
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tgtatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2317
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2317
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2318
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2318
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2319
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2319
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2320
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2320
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccat aaataagaag catcaaag                   108


<210>  2321
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2321
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2322
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2322
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2323
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2323
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccataa ataagaagca tcaaag                     106


<210>  2324
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2324
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  2325
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2325
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2326
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2326
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2327
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2327
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2328
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2328
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2329
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2329
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2330
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2330
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2331
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2331
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga taaataagag agcatcaaag                 110


<210>  2332
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2332
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2333
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2333
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2334
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2334
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2335
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2335
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2336
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2336
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2337
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2337
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2338
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2338
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2339
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2339
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2340
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2340
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2341
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2341
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2342
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2342
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2343
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2343
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2344
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2344
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  2345
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2345
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2346
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2346
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaagc                   108


<210>  2347
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2347
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2348
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2348
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgaa taaataagaa gcatcaaag                  109


<210>  2349
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2349
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2350
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2350
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gatccgataa ataagaagca tcaaag                     106


<210>  2351
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2351
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2352
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2352
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2353
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2353
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2354
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2354
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2355
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2355
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2356
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2356
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2357
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2357
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg agaaatccga taaataagaa gcatcaaag                  109


<210>  2358
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2358
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2359
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2359
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  2360
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2360
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2361
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2361
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2362
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2362
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2363
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2363
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2364
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2364
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2365
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2365
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagc atccgataaa taagaagcat caaag                      105


<210>  2366
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2366
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  2367
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2367
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2368
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2368
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2369
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2369
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  2370
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2370
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  2371
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2371
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  2372
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2372
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2373
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2373
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2374
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2374
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2375
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2375
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2376
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2376
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2377
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2377
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2378
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2378
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatctcgat aaataagaag catcaaag                   108


<210>  2379
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2379
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2380
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2380
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2381
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2381
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2382
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2382
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  2383
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2383
tactggcgct tttatctcat tactttgaga gccataacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2384
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2384
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2385
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2385
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  2386
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2386
gctggcgctt ttaatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2387
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2387
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccta aataagaagc atcaaag                    107


<210>  2388
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2388
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt aatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2389
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2389
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2390
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2390
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataagt aaagcatcaa ag              112


<210>  2391
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2391
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag agaaatccga taaataagaa gcatcaaag                  109


<210>  2392
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2392
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata gtaagaagca tcaaag                     106


<210>  2393
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2393
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2394
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2394
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2395
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2395
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  2396
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2396
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2397
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2397
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2398
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2398
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2399
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2399
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2400
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2400
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  2401
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2401
tactggcgct tttatttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2402
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2402
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2403
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2403
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaag aaatccgata aataagaagc atcaaag                    107


<210>  2404
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2404
actggcgctt ttatctatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2405
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2405
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2406
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2406
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2407
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2407
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2408
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2408
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2409
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2409
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2410
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2410
tcctggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2411
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2411
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2412
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2412
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2413
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2413
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2414
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2414
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2415
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2415
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2416
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2416
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagc atccgataaa taagaagcat caaag                      105


<210>  2417
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2417
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagag agcatcaaag                 110


<210>  2418
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2418
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2419
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2419
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  2420
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2420
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2421
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2421
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2422
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2422
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2423
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2423
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2424
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2424
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2425
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2425
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2426
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2426
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2427
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2427
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagg atccgataaa taagaagcat caaag                      105


<210>  2428
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2428
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2429
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2429
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2430
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2430
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2431
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2431
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2432
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2432
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taataagaag catcaaag                   108


<210>  2433
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2433
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2434
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2434
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2435
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2435
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2436
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2436
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2437
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2437
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2438
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2438
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2439
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2439
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2440
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2440
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2441
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2441
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2442
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2442
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2443
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2443
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2444
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2444
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcacgataa ataagaagca tcaaag                     106


<210>  2445
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2445
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2446
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2446
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2447
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2447
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2448
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2448
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2449
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2449
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatagggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2450
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2450
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  2451
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2451
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2452
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2452
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2453
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2453
cctgtcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2454
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2454
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga tcatccgata aataagaagc atcaaag                    107


<210>  2455
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2455
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2456
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2456
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2457
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2457
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2458
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2458
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2459
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2459
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  2460
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2460
tctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2461
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2461
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2462
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2462
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2463
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2463
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2464
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2464
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2465
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2465
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  2466
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2466
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2467
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2467
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2468
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2468
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2469
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2469
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2470
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2470
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2471
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2471
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2472
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2472
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2473
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2473
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2474
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2474
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2475
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2475
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  2476
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2476
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2477
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2477
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatagat aaataagaag catcaaag                   108


<210>  2478
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2478
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2479
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2479
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2480
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2480
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2481
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2481
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2482
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2482
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatctcgat aaataagaag catcaaag                   108


<210>  2483
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2483
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2484
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2484
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2485
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2485
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctcgag aaatccgata aataagaagc atcaaag                    107


<210>  2486
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2486
ctggcgcttt tatctgcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2487
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2487
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2488
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2488
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgt ataaataaga agcatcaaag                 110


<210>  2489
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2489
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaaaagata aataagaagc atcaaag                    107


<210>  2490
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2490
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2491
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2491
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  2492
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2492
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2493
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2493
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2494
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2494
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2495
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2495
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aataccgata aataagaagc atcaaag                    107


<210>  2496
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2496
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2497
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2497
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2498
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2498
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  2499
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2499
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2500
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2500
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2501
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2501
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2502
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2502
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2503
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2503
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2504
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2504
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2505
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2505
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2506
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2506
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2507
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2507
tctggcgctt ttattcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2508
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2508
tactggcgct tttatcttat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2509
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2509
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2510
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2510
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  2511
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2511
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  2512
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2512
tctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2513
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2513
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatcgat aaataagaag catcaaag                   108


<210>  2514
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2514
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2515
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2515
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2516
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2516
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2517
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2517
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2518
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2518
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccataa ataagaagca tcaaag                     106


<210>  2519
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2519
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2520
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2520
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2521
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2521
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2522
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2522
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2523
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2523
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2524
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2524
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2525
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2525
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2526
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2526
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2527
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2527
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2528
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2528
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2529
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2529
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2530
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2530
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2531
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2531
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2532
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2532
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2533
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2533
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2534
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2534
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaaatccgat aaataagaag catcaaag                   108


<210>  2535
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2535
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2536
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2536
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2537
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2537
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  2538
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2538
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2539
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2539
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2540
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2540
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2541
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2541
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2542
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2542
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tcttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2543
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2543
tctggcgctt ttatctatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2544
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2544
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2545
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2545
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2546
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2546
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2547
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2547
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2548
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2548
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2549
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2549
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2550
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2550
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2551
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2551
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2552
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2552
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2553
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2553
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2554
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2554
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaatccgat aaataagaag catcaaag                   108


<210>  2555
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2555
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  2556
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2556
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaatccgat aaataagaag catcaaag                   108


<210>  2557
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2557
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2558
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2558
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2559
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2559
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga tgataagaag catcaaag                   108


<210>  2560
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2560
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  2561
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2561
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2562
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2562
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2563
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2563
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag aaatccgata aataagaagc atcaaag                    107


<210>  2564
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2564
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2565
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2565
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2566
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2566
tctggcgctt ttatcatcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2567
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2567
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2568
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2568
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtagag aaatccgata aataagaagc atcaaag                    107


<210>  2569
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2569
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  2570
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2570
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2571
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2571
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2572
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2572
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2573
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2573
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2574
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2574
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2575
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2575
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  2576
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2576
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2577
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2577
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2578
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2578
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2579
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2579
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  2580
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2580
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga taaataagag agcatcaaag                 110


<210>  2581
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2581
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2582
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2582
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2583
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2583
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2584
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2584
ctggcgcttt tatcccatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2585
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2585
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2586
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2586
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2587
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2587
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2588
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2588
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2589
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2589
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2590
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2590
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2591
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2591
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2592
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2592
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2593
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2593
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  2594
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2594
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2595
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2595
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2596
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2596
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2597
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2597
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2598
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2598
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2599
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2599
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2600
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2600
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2601
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2601
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2602
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2602
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2603
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2603
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2604
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2604
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2605
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2605
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  2606
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2606
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2607
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2607
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2608
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2608
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2609
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2609
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2610
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2610
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2611
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2611
cactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2612
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2612
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaaag catcaaag                   108


<210>  2613
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2613
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2614
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2614
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2615
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2615
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2616
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2616
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2617
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2617
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2618
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2618
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agtatccgat aaataagaag catcaaag                   108


<210>  2619
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2619
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  2620
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2620
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2621
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2621
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatcgat aaataagaag catcaaag                   108


<210>  2622
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2622
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2623
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2623
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2624
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2624
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2625
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2625
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tataggagag aaatccgata aataagaagc atcaaag                    107


<210>  2626
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2626
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgg taaataagaa gcatcaaag                  109


<210>  2627
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2627
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2628
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2628
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2629
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2629
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2630
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2630
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2631
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2631
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg aaatccgata aataagaagc atcaaag                    107


<210>  2632
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2632
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2633
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2633
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2634
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2634
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2635
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2635
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2636
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2636
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2637
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2637
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2638
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2638
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2639
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2639
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  2640
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2640
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  2641
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2641
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2642
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2642
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2643
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2643
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2644
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2644
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag attccgataa ataagaagca tcaaag                     106


<210>  2645
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2645
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag ggaaatccga taaataagaa gcatcaaag                  109


<210>  2646
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2646
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2647
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2647
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tgtatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2648
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2648
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2649
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2649
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2650
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2650
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2651
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2651
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2652
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2652
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag aaatccgata aataagaagc atcaaag                    107


<210>  2653
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2653
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2654
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2654
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2655
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2655
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaaag catcaaag                   108


<210>  2656
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2656
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2657
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2657
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2658
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2658
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2659
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2659
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2660
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2660
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2661
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2661
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2662
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2662
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2663
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2663
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2664
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2664
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2665
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2665
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2666
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2666
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2667
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2667
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2668
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2668
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2669
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2669
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga tccgataaat aagaagcatc aaag                       104


<210>  2670
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2670
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2671
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2671
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2672
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2672
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2673
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2673
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2674
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2674
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2675
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2675
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2676
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2676
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2677
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2677
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2678
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2678
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2679
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2679
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2680
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2680
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2681
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2681
cctggcgctc ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2682
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2682
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2683
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2683
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2684
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2684
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2685
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2685
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2686
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2686
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2687
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2687
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2688
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2688
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagagag catcaaag                   108


<210>  2689
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2689
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagt aaatccgata aataagaagc atcaaag                    107


<210>  2690
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2690
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2691
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2691
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2692
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2692
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2693
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2693
cctggcgctt ttatctcata actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2694
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2694
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2695
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2695
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  2696
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2696
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2697
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2697
ccttgcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2698
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2698
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2699
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2699
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaagc                   108


<210>  2700
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2700
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2701
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2701
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2702
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2702
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2703
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2703
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2704
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2704
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaga gcatcaaag                  109


<210>  2705
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2705
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2706
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2706
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaataccga taaataagaa gcatcaaag                  109


<210>  2707
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2707
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2708
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2708
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2709
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2709
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2710
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2710
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2711
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2711
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2712
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2712
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2713
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2713
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2714
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2714
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga tgataagaag catcaaag                   108


<210>  2715
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2715
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2716
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2716
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga tagtaagaag catcaaag                   108


<210>  2717
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2717
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2718
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2718
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2719
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2719
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2720
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2720
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  2721
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2721
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2722
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2722
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2723
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2723
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2724
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2724
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2725
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2725
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcacgat aaataagaag catcaaag                   108


<210>  2726
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2726
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2727
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2727
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2728
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2728
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtga gaaatccgat aaataagaag catcaaag                   108


<210>  2729
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2729
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2730
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2730
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2731
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2731
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaagc                   108


<210>  2732
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2732
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2733
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2733
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2734
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2734
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2735
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2735
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2736
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2736
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taaatccgat aaataagaag catcaaag                   108


<210>  2737
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2737
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  2738
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2738
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2739
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2739
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt aaatccgata aataagaagc atcaaag                    107


<210>  2740
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2740
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2741
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2741
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  2742
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2742
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  2743
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2743
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2744
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2744
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgttag aaatccgata aataagaagc atcaaag                    107


<210>  2745
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2745
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  2746
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2746
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2747
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2747
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2748
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2748
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agagaatccg ataaataaga agcatcaaag                 110


<210>  2749
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2749
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  2750
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2750
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2751
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2751
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag agaaatccga taaataagaa gcatcaaag                  109


<210>  2752
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2752
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2753
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2753
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2754
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2754
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2755
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2755
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2756
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2756
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccataa ataagaagca tcaaag                     106


<210>  2757
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2757
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg aaatccgata aataagaagc atcaaag                    107


<210>  2758
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2758
tactggcgct tttatctcat tactttgaga gccataacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2759
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2759
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2760
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2760
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2761
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2761
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2762
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2762
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2763
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2763
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gattccgata aataagaagc atcaaag                    107


<210>  2764
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2764
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2765
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2765
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2766
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2766
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2767
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2767
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2768
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2768
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag agaaatccga taaataagaa gcatcaaag                  109


<210>  2769
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2769
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccataa ataagaagca tcaaag                     106


<210>  2770
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2770
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2771
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2771
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2772
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2772
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2773
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2773
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2774
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2774
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2775
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2775
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaaacgata aataagaagc atcaaag                    107


<210>  2776
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2776
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2777
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2777
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2778
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2778
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2779
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2779
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2780
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2780
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  2781
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2781
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaaag catcaaag                   108


<210>  2782
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2782
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatagagag aaatccgata aataagaagc atcaaag                    107


<210>  2783
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2783
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2784
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2784
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2785
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2785
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2786
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2786
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2787
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2787
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2788
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2788
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  2789
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2789
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2790
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2790
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2791
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2791
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2792
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2792
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2793
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2793
tctgtcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2794
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2794
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2795
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2795
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agtatccgat aaataagaag catcaaag                   108


<210>  2796
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2796
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2797
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2797
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2798
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2798
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2799
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2799
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2800
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2800
tactggcgct tttatctaca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2801
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2801
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2802
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2802
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2803
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2803
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2804
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2804
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  2805
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2805
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2806
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2806
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2807
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2807
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2808
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2808
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2809
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2809
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2810
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2810
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2811
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2811
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2812
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2812
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2813
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2813
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2814
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2814
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2815
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2815
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2816
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2816
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2817
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2817
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2818
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2818
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2819
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2819
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2820
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2820
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2821
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2821
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2822
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2822
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2823
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2823
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  2824
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2824
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2825
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2825
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2826
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2826
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2827
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2827
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2828
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2828
cctggcgctt ttattcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2829
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2829
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccat aaataagaag catcaaag                   108


<210>  2830
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2830
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2831
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2831
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaagc                   108


<210>  2832
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2832
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2833
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2833
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2834
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2834
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  2835
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2835
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2836
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2836
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2837
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2837
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2838
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2838
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattcgata aataagaagc atcaaag                    107


<210>  2839
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2839
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  2840
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2840
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2841
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2841
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2842
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2842
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaaatccg ataaataaga agcatcaaag                 110


<210>  2843
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2843
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2844
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2844
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2845
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2845
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2846
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2846
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2847
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2847
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2848
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2848
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2849
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2849
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2850
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2850
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2851
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2851
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taataagaag catcaaag                   108


<210>  2852
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2852
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga tagtaagaag catcaaag                   108


<210>  2853
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2853
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2854
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2854
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2855
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2855
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2856
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2856
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2857
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2857
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2858
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2858
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2859
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2859
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2860
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2860
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2861
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2861
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga tagtaagaag catcaaag                   108


<210>  2862
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2862
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2863
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2863
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgag agaaatccga taaataagaa gcatcaaag                  109


<210>  2864
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2864
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2865
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2865
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2866
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2866
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga ataaataaga agcatcaaag                 110


<210>  2867
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2867
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2868
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2868
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2869
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2869
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2870
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2870
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2871
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2871
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2872
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2872
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2873
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2873
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2874
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2874
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2875
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2875
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2876
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2876
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2877
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2877
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2878
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2878
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2879
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2879
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  2880
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2880
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2881
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2881
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2882
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2882
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2883
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2883
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagag agcatcaaag                 110


<210>  2884
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2884
tactggcgct tttatctcat tactttgaga gccatcaaca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2885
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2885
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatagggag aaatccgata aataagaagc atcaaag                    107


<210>  2886
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2886
tactggcgct tttatcccat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2887
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2887
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccat aaataagaag catcaaag                   108


<210>  2888
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2888
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2889
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2889
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2890
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2890
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2891
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2891
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgaagag aaatccgata aataagaagc atcaaag                    107


<210>  2892
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2892
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2893
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2893
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2894
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2894
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2895
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2895
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2896
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2896
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2897
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2897
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2898
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2898
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2899
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2899
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2900
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2900
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2901
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2901
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  2902
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2902
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2903
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2903
cactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2904
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2904
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  2905
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2905
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2906
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2906
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2907
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2907
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2908
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2908
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgcat aaataagaag catcaaag                   108


<210>  2909
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2909
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2910
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2910
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2911
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2911
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2912
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2912
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccat aaataagaag catcaaag                   108


<210>  2913
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2913
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2914
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2914
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2915
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2915
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2916
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2916
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag gaatccgata aataagaagc atcaaag                    107


<210>  2917
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2917
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2918
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2918
cctggcgctt ttatcccatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2919
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2919
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2920
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2920
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2921
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2921
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2922
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2922
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2923
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2923
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tctggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2924
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2924
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2925
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2925
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2926
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2926
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2927
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2927
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2928
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2928
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2929
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2929
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2930
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2930
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2931
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2931
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag aaatccgata aataagaagc atcaaag                    107


<210>  2932
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2932
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2933
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2933
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2934
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2934
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatcccgat aaataagaag catcaaag                   108


<210>  2935
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2935
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2936
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2936
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2937
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2937
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2938
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2938
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2939
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2939
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2940
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2940
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2941
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2941
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcacttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2942
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2942
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2943
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2943
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2944
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2944
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2945
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2945
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2946
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2946
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2947
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2947
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  2948
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2948
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2949
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2949
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2950
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2950
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2951
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2951
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2952
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2952
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2953
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2953
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2954
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2954
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2955
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2955
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2956
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2956
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2957
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2957
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  2958
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2958
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  2959
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2959
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2960
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2960
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2961
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2961
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2962
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2962
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2963
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2963
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2964
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2964
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2965
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2965
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2966
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2966
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2967
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2967
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2968
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2968
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2969
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2969
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2970
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2970
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2971
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2971
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag ggaaatccga taaataagaa gcatcaaag                  109


<210>  2972
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2972
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2973
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2973
cctggcgctt ttatctaatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2974
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2974
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2975
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2975
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2976
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2976
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2977
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2977
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2978
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2978
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2979
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2979
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2980
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2980
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2981
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2981
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  2982
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2982
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2983
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2983
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2984
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2984
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2985
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2985
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2986
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2986
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2987
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2987
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2988
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2988
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2989
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2989
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag aggatccgat aaataagaag catcaaag                   108


<210>  2990
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2990
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2991
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2991
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2992
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2992
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2993
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2993
tactggcgct tttatttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2994
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2994
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2995
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2995
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2996
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2996
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2997
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2997
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2998
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2998
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2999
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2999
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  3000
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3000
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt agtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3001
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3001
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3002
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3002
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  3003
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3003
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3004
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3004
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3005
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3005
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gatccgataa ataagaagca tcaaag                     106


<210>  3006
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3006
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3007
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3007
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3008
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3008
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3009
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3009
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3010
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3010
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3011
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3011
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3012
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3012
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3013
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3013
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3014
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3014
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  3015
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3015
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaagc                   108


<210>  3016
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3016
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  3017
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3017
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3018
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3018
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3019
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3019
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3020
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3020
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3021
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3021
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3022
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3022
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3023
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3023
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3024
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3024
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3025
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3025
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3026
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3026
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3027
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3027
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  3028
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3028
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3029
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3029
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3030
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3030
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3031
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3031
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtga gaaatccgat aaataagaag catcaaag                   108


<210>  3032
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3032
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3033
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3033
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  3034
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3034
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3035
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3035
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3036
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3036
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3037
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3037
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  3038
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3038
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3039
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3039
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3040
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3040
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3041
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3041
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  3042
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3042
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3043
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3043
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3044
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3044
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3045
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3045
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3046
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3046
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  3047
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3047
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3048
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3048
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3049
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3049
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3050
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3050
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3051
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3051
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  3052
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3052
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3053
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3053
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  3054
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3054
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3055
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3055
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  3056
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3056
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaagc                   108


<210>  3057
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3057
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3058
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3058
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aatccgataa ataagaagca tcaaag                     106


<210>  3059
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3059
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3060
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3060
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3061
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3061
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3062
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3062
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3063
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3063
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3064
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3064
catggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3065
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3065
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3066
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3066
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  3067
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3067
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3068
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3068
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3069
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3069
cctggcgctt ttatctcatt actttgagag caatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3070
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3070
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag gaatccgata aataagaagc atcaaag                    107


<210>  3071
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3071
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3072
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3072
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3073
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3073
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  3074
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3074
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3075
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3075
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3076
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3076
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3077
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3077
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3078
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3078
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3079
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3079
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3080
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3080
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3081
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3081
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggga gaaatccgat aaataagaag catcaaag                   108


<210>  3082
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3082
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3083
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3083
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  3084
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3084
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3085
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3085
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3086
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3086
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  3087
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3087
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag aggaatccga taaataagaa gcatcaaag                  109


<210>  3088
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3088
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3089
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3089
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgaggg aaatccgata aataagaagc atcaaag                    107


<210>  3090
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3090
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  3091
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3091
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatatagag aaatccgata aataagaagc atcaaag                    107


<210>  3092
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3092
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3093
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3093
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3094
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3094
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3095
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3095
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcctgag agaaatccga taaataagaa gcatcaaag                  109


<210>  3096
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3096
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3097
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3097
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3098
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3098
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3099
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3099
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc ataaaag                    107


<210>  3100
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3100
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3101
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3101
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3102
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3102
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  3103
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3103
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  3104
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3104
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3105
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3105
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3106
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3106
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3107
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3107
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatcgataa ataagaagca tcaaag                     106


<210>  3108
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3108
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3109
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3109
cctggcgctt ttatcttatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3110
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3110
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3111
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3111
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3112
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3112
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3113
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3113
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3114
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3114
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3115
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3115
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3116
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3116
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3117
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3117
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3118
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3118
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3119
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3119
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3120
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3120
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3121
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3121
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3122
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3122
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagccttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3123
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3123
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3124
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3124
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3125
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3125
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3126
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3126
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaccgagag aaatccgata aataagaagc atcaaag                    107


<210>  3127
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3127
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3128
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3128
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3129
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3129
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3130
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3130
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3131
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3131
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3132
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3132
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3133
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3133
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3134
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3134
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3135
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3135
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3136
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3136
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3137
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3137
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3138
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3138
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3139
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3139
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3140
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3140
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcagata aataagaagc atcaaag                    107


<210>  3141
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3141
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaatccgat aaataagaag catcaaag                   108


<210>  3142
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3142
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3143
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3143
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccataa ataagaagca tcaaag                     106


<210>  3144
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3144
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccataa ataagaagca tcaaag                     106


<210>  3145
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3145
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3146
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3146
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3147
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3147
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatacgata aataagaagc atcaaag                    107


<210>  3148
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3148
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3149
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3149
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3150
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3150
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3151
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3151
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3152
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3152
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3153
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3153
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3154
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3154
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3155
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3155
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3156
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3156
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3157
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3157
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  3158
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3158
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3159
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3159
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3160
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3160
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3161
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3161
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3162
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3162
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3163
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3163
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3164
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3164
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3165
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3165
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3166
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3166
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaaga atcaaag                    107


<210>  3167
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3167
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3168
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3168
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3169
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3169
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3170
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3170
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3171
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3171
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3172
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3172
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3173
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3173
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3174
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3174
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3175
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3175
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3176
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3176
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  3177
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3177
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3178
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3178
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3179
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3179
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3180
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3180
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaagc                   108


<210>  3181
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3181
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatggttaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3182
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3182
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3183
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3183
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3184
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3184
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3185
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3185
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3186
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3186
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3187
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3187
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3188
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3188
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3189
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3189
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3190
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3190
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3191
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3191
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3192
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3192
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3193
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3193
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3194
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3194
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3195
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3195
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  3196
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3196
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3197
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3197
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3198
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3198
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3199
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3199
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3200
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3200
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3201
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3201
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3202
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3202
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3203
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3203
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3204
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3204
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  3205
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3205
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3206
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3206
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3207
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3207
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3208
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3208
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3209
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3209
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  3210
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3210
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3211
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3211
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3212
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3212
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3213
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3213
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3214
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3214
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3215
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3215
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3216
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3216
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3217
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3217
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3218
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3218
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3219
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3219
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag aaatccgata aataagaagc atcaaag                    107


<210>  3220
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3220
tactggcgct tttatctcat tactttgaga gccataacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3221
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3221
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3222
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3222
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgcat aaataagaag catcaaag                   108


<210>  3223
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3223
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3224
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3224
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3225
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3225
tactggctct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3226
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3226
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3227
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3227
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttataggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3228
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3228
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3229
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3229
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3230
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3230
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3231
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3231
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3232
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3232
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3233
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3233
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3234
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3234
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3235
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3235
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3236
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3236
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3237
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3237
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3238
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3238
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3239
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3239
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt agtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3240
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3240
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3241
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3241
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3242
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3242
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3243
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3243
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3244
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3244
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3245
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3245
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3246
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3246
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3247
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3247
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggggg aaatccgata aataagaagc atcaaag                    107


<210>  3248
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3248
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3249
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3249
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3250
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3250
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3251
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3251

Gly Ser Pro Gly 
1               


<210>  3252
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3252

Ala Leu Ser Asp Ala 
1               5   


<210>  3253
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3253

Ala Tyr Glu Gly 
1               


<210>  3254
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3254

Asp Leu Leu Tyr 
1               


<210>  3255
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3255

Glu Ala Phe Glu 
1               


<210>  3256
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3256

Glu Ala Trp Glu Arg Ile Asp Lys Lys Val 
1               5                   10  


<210>  3257
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3257

Glu Leu Asp Arg 
1               


<210>  3258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3258

Phe Met Ala Glu Arg Gln Tyr 
1               5           


<210>  3259
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3259

Phe Val Ala Leu 
1               


<210>  3260
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3260

Gly Cys Pro Leu 
1               


<210>  3261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3261

Gly Gly Lys Leu Arg Phe Lys 
1               5           


<210>  3262
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3262

Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
1               5                   10      


<210>  3263
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3263

Gly Asn Pro Thr 
1               


<210>  3264
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3264

His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
1               5                   10  


<210>  3265
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3265

Ile Leu Arg Ile 
1               


<210>  3266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3266

Lys Asp Ser Asn Thr Lys Lys 
1               5           


<210>  3267
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3267

Lys Gly Phe Pro Ser 
1               5   


<210>  3268
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3268

Lys Lys His Gly Glu 
1               5   


<210>  3269
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3269

Lys Lys His Gly Glu Asp Trp Gly 
1               5               


<210>  3270
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3270

Lys Pro Leu Gln Arg Leu 
1               5       


<210>  3271
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3271

Lys Gln Tyr Asn Cys Ala 
1               5       


<210>  3272
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3272

Lys Ser Gly Glu Ile 
1               5   


<210>  3273
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3273

Lys Trp Tyr Gly 
1               


<210>  3274
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3274

Lys Trp Tyr Gly Asp 
1               5   


<210>  3275
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3275

Lys Trp Tyr Gly Asp Leu 
1               5       


<210>  3276
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3276

Leu Asp Phe Tyr Ser Ile His 
1               5           


<210>  3277
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3277

Leu Asp Phe Tyr Ser Ile His Val 
1               5               


<210>  3278
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3278

Gly Ser Pro Gly Ile 
1               5   


<210>  3279
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3279

Gly Ser Pro Gly Ile Lys 
1               5       


<210>  3280
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3280

Leu Glu Gln Ile Gly 
1               5   


<210>  3281
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3281

Leu Glu Gln Ile Gly Gly 
1               5       


<210>  3282
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3282

Asn Cys Gly Phe Glu Thr 
1               5       


<210>  3283
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3283

Asn Leu Tyr Leu 
1               


<210>  3284
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3284

Pro Lys Ile Thr Leu Pro 
1               5       


<210>  3285
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3285

Arg Cys Glu Leu Lys 
1               5   


<210>  3286
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3286

Arg Ile Asp Lys Lys Val 
1               5       


<210>  3287
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3287

Arg Ser Trp Leu Phe Leu 
1               5       


<210>  3288
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3288

Ser Glu Asp Ala Gln Ser 
1               5       


<210>  3289
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3289

Thr Gly Trp Met 
1               


<210>  3290
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3290

Thr Ile Asn Gly 
1               


<210>  3291
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3291

Thr Leu Tyr Asn 
1               


<210>  3292
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3292

Thr Leu Tyr Asn Arg Arg Thr Arg 
1               5               


<210>  3293
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3293

Val Ala Gln Ile Val 
1               5   


<210>  3294
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3294

Val Lys Asp Ser Asn Thr Lys 
1               5           


<210>  3295
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3295

Val Thr Tyr Ser 
1               


<210>  3296
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3296

Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
1               5                   10  


<210>  3297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant reference

<400>  3297

Val Tyr Asp Glu Ala Trp Glu 
1               5           


<210>  3298
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3298

Ala Ala Glu Gln 
1               


<210>  3299
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3299

Ala Ala Glu Gln Ala 
1               5   


<210>  3300
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3300

Ala Ala Lys Glu Val Glu Gln Arg 
1               5               


<210>  3301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3301

Ala Ala Ser Cys Gly Ser Arg 
1               5           


<210>  3302
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3302

Ala Asp Asp Met 
1               


<210>  3303
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3303

Ala Asp Asp Met Val 
1               5   


<210>  3304
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3304

Ala Asp Asp Met Val Arg 
1               5       


<210>  3305
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3305

Ala Asp Asp Met Val Arg Asn 
1               5           


<210>  3306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3306

Ala Asp Lys Asp Glu Phe Cys 
1               5           


<210>  3307
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3307

Ala Asp Tyr Asp 
1               


<210>  3308
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3308

Ala Glu Gln Ala Ala Leu Asn 
1               5           


<210>  3309
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3309

Ala Glu Arg Gln Tyr 
1               5   


<210>  3310
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3310

Ala Phe Glu Ala Asn Arg Phe Tyr 
1               5               


<210>  3311
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3311

Ala Phe Gly Lys 
1               


<210>  3312
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3312

Ala Phe Gly Lys Arg Gln Gly 
1               5           


<210>  3313
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3313

Ala Gly Tyr Lys Arg Gln 
1               5       


<210>  3314
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3314

Ala Lys Glu Val Glu Gln Arg 
1               5           


<210>  3315
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3315

Ala Lys Asn Leu 
1               


<210>  3316
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3316

Ala Lys Pro Leu Gln Arg Leu Lys 
1               5               


<210>  3317
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3317

Ala Leu Asp Phe Tyr 
1               5   


<210>  3318
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3318

Ala Leu Leu Pro 
1               


<210>  3319
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3319

Ala Leu Leu Pro Tyr 
1               5   


<210>  3320
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3320

Ala Leu Asn Ile 
1               


<210>  3321
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3321

Ala Leu Ser Asp Ala Cys Met 
1               5           


<210>  3322
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3322

Ala Leu Thr Asp 
1               


<210>  3323
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3323

Ala Leu Thr Asp Pro Glu 
1               5       


<210>  3324
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3324

Ala Leu Thr Asp Trp Leu Arg 
1               5           


<210>  3325
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3325

Ala Asn Leu Lys Asp Ile 
1               5       


<210>  3326
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3326

Ala Asn Leu Ser 
1               


<210>  3327
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3327

Ala Asn Arg Phe Tyr 
1               5   


<210>  3328
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3328

Ala Gln Ile Val Ile Trp 
1               5       


<210>  3329
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3329

Ala Gln Ser Lys 
1               


<210>  3330
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3330

Ala Ser Gly Pro Val Gly 
1               5       


<210>  3331
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3331

Ala Ser Ser Asp Arg Glu Pro Trp Thr Ser Thr 
1               5                   10      


<210>  3332
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3332

Ala Ser Ser Lys 
1               


<210>  3333
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3333

Ala Ser Ser Lys Asp Leu Gln Ala Ser Asn 
1               5                   10  


<210>  3334
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3334

Ala Thr Leu His 
1               


<210>  3335
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3335

Ala Val Thr Gln 
1               


<210>  3336
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3336

Ala Val Thr Gln Asp 
1               5   


<210>  3337
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3337

Ala Trp Glu Arg Ile Asp Lys 
1               5           


<210>  3338
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3338

Ala Tyr Asn Asn Val 
1               5   


<210>  3339
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3339

Cys Asn Val Ser Glu 
1               5   


<210>  3340
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3340

Cys Thr Met Arg Pro Gly 
1               5       


<210>  3341
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3341

Asp Ala Cys Met 
1               


<210>  3342
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3342

Asp Ala Cys Met Gly 
1               5   


<210>  3343
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3343

Asp Ala Cys Met Gly Ala Val 
1               5           


<210>  3344
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3344

Asp Ala Gln Ser Lys 
1               5   


<210>  3345
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3345

Asp Asp Met Val 
1               


<210>  3346
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3346

Asp Asp Pro Asn Leu Ile Ile 
1               5           


<210>  3347
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3347

Asp Glu Ala Trp 
1               


<210>  3348
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3348

Asp Glu Ala Trp Glu 
1               5   


<210>  3349
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3349

Asp Glu Ala Trp Glu Arg Ile Asp 
1               5               


<210>  3350
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3350

Asp Glu Phe Cys Arg 
1               5   


<210>  3351
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3351

Asp Glu Phe Cys Arg Cys Glu 
1               5           


<210>  3352
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3352

Asp Glu Leu Val 
1               


<210>  3353
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3353

Asp Phe Tyr Ser Ile 
1               5   


<210>  3354
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3354

Asp Phe Tyr Ser Ile His 
1               5       


<210>  3355
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3355

Asp His Ser Arg Asp 
1               5   


<210>  3356
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3356

Asp Ile Ser Gly 
1               


<210>  3357
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3357

Asp Ile Ser Gly Phe Ser 
1               5       


<210>  3358
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3358

Asp Ile Ser Ser 
1               


<210>  3359
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3359

Asp Lys Arg Ala 
1               


<210>  3360
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3360

Asp Lys Arg Ala Phe Val 
1               5       


<210>  3361
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3361

Asp Leu Leu Leu His 
1               5   


<210>  3362
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3362

Asp Leu Leu Leu His Leu 
1               5       


<210>  3363
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3363

Asp Leu Leu Ser 
1               


<210>  3364
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3364

Asp Leu Leu Ser Leu Glu 
1               5       


<210>  3365
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3365

Asp Leu Ser Val Glu Leu 
1               5       


<210>  3366
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3366

Asp Met Val Cys 
1               


<210>  3367
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3367

Asp Asn Gln Val 
1               


<210>  3368
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3368

Asp Asn Gln Val Gly 
1               5   


<210>  3369
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3369

Asp Arg Lys Lys 
1               


<210>  3370
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3370

Asp Trp Gly Lys Val Tyr 
1               5       


<210>  3371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3371

Asp Tyr Asp Arg Val Leu Glu 
1               5           


<210>  3372
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3372

Glu Ala Ala Val Gln Ala 
1               5       


<210>  3373
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3373

Glu Ala Asp Lys Asp Glu Phe Cys 
1               5               


<210>  3374
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3374

Glu Ala Glu Asn Ser Ile Leu 
1               5           


<210>  3375
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3375

Glu Ala Phe Glu 
1               


<210>  3376
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3376

Glu Ala Gly Cys Ser 
1               5   


<210>  3377
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3377

Glu Ala Asn Asp Glu 
1               5   


<210>  3378
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3378

Glu Ala Trp Glu 
1               


<210>  3379
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3379

Glu Ala Trp Glu Arg 
1               5   


<210>  3380
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3380

Glu Glu Glu Arg Arg Ser 
1               5       


<210>  3381
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3381

Glu Glu Arg Arg 
1               


<210>  3382
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3382

Glu Glu Arg Arg Ser 
1               5   


<210>  3383
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3383

Glu Phe Cys Arg Cys 
1               5   


<210>  3384
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3384

Glu Gly Leu Ser 
1               


<210>  3385
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3385

Glu Gly Gln Ile 
1               


<210>  3386
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3386

Glu Gly Gln Ile Thr 
1               5   


<210>  3387
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3387

Glu Gly Gln Ile Thr Tyr 
1               5       


<210>  3388
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3388

Glu Gly Gln Ile Thr Tyr Tyr 
1               5           


<210>  3389
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3389

Glu Gly Gln Ile Thr Tyr Tyr Asn 
1               5               


<210>  3390
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3390

Glu His Glu Arg Leu Ile 
1               5       


<210>  3391
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3391

Glu Lys Lys Glu Asp 
1               5   


<210>  3392
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3392

Glu Lys Lys His Gly 
1               5   


<210>  3393
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3393

Glu Arg Ile Asp Lys Lys Val 
1               5           


<210>  3394
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3394

Glu Arg Leu Ile 
1               


<210>  3395
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3395

Glu Arg Arg Glu Val Leu Asp 
1               5           


<210>  3396
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3396

Glu Ser Asn His Pro Val 
1               5       


<210>  3397
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3397

Glu Ser Val Asn Asn Asp 
1               5       


<210>  3398
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3398

Glu Thr His Ala 
1               


<210>  3399
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3399

Glu Thr His Ala Ala 
1               5   


<210>  3400
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3400

Glu Thr His Ala Ala Glu 
1               5       


<210>  3401
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3401

Glu Thr His Ala Asp Glu 
1               5       


<210>  3402
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3402

Glu Thr Trp Gln Ser 
1               5   


<210>  3403
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3403

Glu Thr Trp Gln Ser Phe Tyr 
1               5           


<210>  3404
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3404

Glu Val Leu Asp 
1               


<210>  3405
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3405

Glu Val Leu Asp Ser 
1               5   


<210>  3406
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3406

Glu Val Leu Asp Ser Ser Asn 
1               5           


<210>  3407
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3407

Glu Val Asn Phe Asn 
1               5   


<210>  3408
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3408

Phe Ala Ile Glu Ala Glu Asn 
1               5           


<210>  3409
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3409

Phe Glu Arg Arg Glu 
1               5   


<210>  3410
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3410

Phe Glu Thr His Ala Ala Glu Gln Ala 
1               5                   


<210>  3411
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3411

Phe Gly Lys Arg Gln Gly 
1               5       


<210>  3412
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3412

Phe Gly Gln Arg Ala Leu Asp 
1               5           


<210>  3413
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3413

Phe Ile Trp Asn 
1               


<210>  3414
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3414

Phe Ile Trp Asn Asp Leu Leu 
1               5           


<210>  3415
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3415

Phe Pro Ser Phe Pro Leu Val 
1               5           


<210>  3416
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3416

Phe Ser Lys Gln Tyr Asn 
1               5       


<210>  3417
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3417

Phe Ser Lys Gln Tyr Asn Cys Ala 
1               5               


<210>  3418
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3418

Phe Ser Ser Lys 
1               


<210>  3419
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3419

Phe Ser Ser Lys Asp Leu Gln 
1               5           


<210>  3420
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3420

Phe Ser Ser Lys Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3421
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3421

Phe Val Cys Leu Asn 
1               5   


<210>  3422
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3422

Phe Tyr Arg Lys Lys 
1               5   


<210>  3423
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3423

Gly Ala Val Ala Ser Phe 
1               5       


<210>  3424
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3424

Gly Cys Pro Leu Ser Arg 
1               5       


<210>  3425
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3425

Gly Cys Pro Leu Ser Arg Phe Lys 
1               5               


<210>  3426
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3426

Gly Asp Leu Leu Leu His 
1               5       


<210>  3427
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3427

Gly Asp Leu Arg 
1               


<210>  3428
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3428

Gly Asp Leu Arg Gly Lys 
1               5       


<210>  3429
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3429

Gly Asp Leu Arg Gly Lys Pro 
1               5           


<210>  3430
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3430

Gly Phe Ser Lys Gln Tyr Asn 
1               5           


<210>  3431
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3431

Gly Gly Asn Ser Cys Ala 
1               5       


<210>  3432
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3432

Gly Gly Asn Ser Cys Ala Ser Gly 
1               5               


<210>  3433
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3433

Gly Lys Glu Leu Lys Val Glu 
1               5           


<210>  3434
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3434

Gly Lys Phe Gly Gln 
1               5   


<210>  3435
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3435

Gly Lys Phe Gly Gln Arg 
1               5       


<210>  3436
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3436

Gly Lys Pro His Thr 
1               5   


<210>  3437
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3437

Gly Lys Pro His Thr Asn 
1               5       


<210>  3438
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3438

Gly Lys Pro His Thr Asn Tyr 
1               5           


<210>  3439
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3439

Gly Lys Pro His Thr Asn Tyr Phe 
1               5               


<210>  3440
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3440

Gly Lys Arg Gln 
1               


<210>  3441
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3441

Gly Lys Val Tyr Asp Glu Ala Trp Glu 
1               5                   


<210>  3442
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3442

Gly Leu Ala Phe Pro Lys 
1               5       


<210>  3443
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3443

Gly Leu Lys Glu Ala Asp Lys 
1               5           


<210>  3444
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3444

Gly Leu Pro Ser Lys 
1               5   


<210>  3445
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3445

Gly Asn Thr Asp 
1               


<210>  3446
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3446

Gly Asn Thr Asp Lys 
1               5   


<210>  3447
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3447

Gly Asn Thr Asp Lys Arg Ala 
1               5           


<210>  3448
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3448

Gly Gln Arg Ala Leu Asp Phe Tyr 
1               5               


<210>  3449
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3449

Gly Arg Glu Phe Ile 
1               5   


<210>  3450
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3450

Gly Arg Glu Phe Ile Trp 
1               5       


<210>  3451
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3451

Gly Arg Ile Ile 
1               


<210>  3452
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3452

Gly Arg Ser Gly Glu Ala 
1               5       


<210>  3453
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3453

Gly Arg Ser Gly Glu Ala Leu 
1               5           


<210>  3454
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3454

Gly Ser Leu Lys Leu Ala Asn 
1               5           


<210>  3455
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3455

Gly Val Lys Lys Leu Asn Leu Tyr 
1               5               


<210>  3456
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3456

Gly Tyr Lys Arg Gln 
1               5   


<210>  3457
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3457

Gly Tyr Ser Arg 
1               


<210>  3458
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3458

Gly Tyr Ser Arg Lys 
1               5   


<210>  3459
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3459

Gly Tyr Ser Arg Lys Tyr Ala Ser 
1               5               


<210>  3460
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3460

His Glu Arg Leu Ile Leu Leu 
1               5           


<210>  3461
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3461

His Ile Lys Leu Glu 
1               5   


<210>  3462
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3462

His Arg Pro Val 
1               


<210>  3463
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3463

His Thr Lys Glu 
1               


<210>  3464
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3464

His Thr Lys Glu Gly 
1               5   


<210>  3465
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3465

His Thr Lys Glu Gly Ile Glu 
1               5           


<210>  3466
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3466

Ile Ala Arg Gly Glu 
1               5   


<210>  3467
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3467

Ile Asp Arg Gly Glu Asn 
1               5       


<210>  3468
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3468

Ile Glu Ala Glu Asn Ser 
1               5       


<210>  3469
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3469

Ile Glu Ala Glu Asn Ser Ile 
1               5           


<210>  3470
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3470

Ile Glu Ala Glu Asn Ser Ile Leu Asp 
1               5                   


<210>  3471
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3471

Ile Glu Lys Thr Leu Tyr Asn 
1               5           


<210>  3472
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3472

Ile Phe Ala Asn Leu Ser 
1               5       


<210>  3473
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3473

Ile Phe Ala Asn Leu Ser Arg 
1               5           


<210>  3474
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3474

Ile Phe Glu Asn Leu Ser 
1               5       


<210>  3475
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3475

Ile Lys Arg Ile Asn Lys 
1               5       


<210>  3476
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3476

Ile Leu Glu His Gln Lys 
1               5       


<210>  3477
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3477

Ile Asn Gly Lys Glu Leu Lys 
1               5           


<210>  3478
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3478

Ile Asn Tyr Phe Lys 
1               5   


<210>  3479
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3479

Ile Pro Ala Val 
1               


<210>  3480
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3480

Ile Gln Ala Ala Lys 
1               5   


<210>  3481
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3481

Ile Gln Ala Ala Lys Glu 
1               5       


<210>  3482
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3482

Ile Ser Ser Lys Asp Leu Gln 
1               5           


<210>  3483
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3483

Ile Thr Tyr Tyr 
1               


<210>  3484
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3484

Ile Thr Tyr Tyr Asn 
1               5   


<210>  3485
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3485

Ile Val Ile Trp 
1               


<210>  3486
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3486

Ile Trp Asn Asp 
1               


<210>  3487
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3487

Ile Trp Asn Asp Leu Leu 
1               5       


<210>  3488
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3488

Ile Trp Gln Lys Asp 
1               5   


<210>  3489
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3489

Lys Asp Ser Leu Gly 
1               5   


<210>  3490
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3490

Lys Glu Ala Asp 
1               


<210>  3491
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3491

Lys Glu Ala Asp Lys Asp Glu 
1               5           


<210>  3492
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3492

Lys Glu Asp Gly 
1               


<210>  3493
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3493

Lys Glu Val Glu Gln Arg 
1               5       


<210>  3494
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3494

Lys Gly Lys Pro His 
1               5   


<210>  3495
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3495

Lys Gly Lys Pro His Thr Asn 
1               5           


<210>  3496
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3496

Lys Gly Lys Pro His Thr Asn Tyr 
1               5               


<210>  3497
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3497

Lys His Gly Glu Asp 
1               5   


<210>  3498
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3498

Lys Lys Gly Lys 
1               


<210>  3499
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3499

Lys Lys Gly Lys Lys 
1               5   


<210>  3500
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3500

Lys Lys His Gly Glu Asp 
1               5       


<210>  3501
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3501

Lys Lys Ile Lys 
1               


<210>  3502
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3502

Lys Lys Leu Ile 
1               


<210>  3503
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3503

Lys Lys Leu Ile Asn Glu 
1               5       


<210>  3504
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3504

Lys Lys Leu Lys Glu Val Trp 
1               5           


<210>  3505
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3505

Lys Lys Asn Glu 
1               


<210>  3506
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3506

Lys Lys Val Glu 
1               


<210>  3507
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3507

Lys Lys Val Glu Gly Leu Ser 
1               5           


<210>  3508
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3508

Lys Lys Tyr Gln Thr Asn 
1               5       


<210>  3509
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3509

Lys Leu Lys Ile Gly Arg Asp Glu Ala 
1               5                   


<210>  3510
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3510

Lys Leu Lys Lys 
1               


<210>  3511
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3511

Lys Leu Asn Leu 
1               


<210>  3512
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3512

Lys Leu Asn Leu Tyr Leu 
1               5       


<210>  3513
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3513

Lys Leu Gln Lys 
1               


<210>  3514
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3514

Lys Leu Gln Lys Trp 
1               5   


<210>  3515
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3515

Lys Leu Arg Phe 
1               


<210>  3516
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3516

Lys Leu Arg Phe Lys 
1               5   


<210>  3517
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3517

Lys Asn Glu Lys Arg 
1               5   


<210>  3518
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3518

Lys Pro Ala Val 
1               


<210>  3519
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3519

Lys Pro Glu Ala 
1               


<210>  3520
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3520

Lys Pro His Thr 
1               


<210>  3521
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3521

Lys Pro His Thr Asn Tyr 
1               5       


<210>  3522
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3522

Lys Pro His Thr Asn Tyr Phe 
1               5           


<210>  3523
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3523

Lys Pro Met Asn 
1               


<210>  3524
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3524

Lys Pro Met Asn Leu Ile Gly 
1               5           


<210>  3525
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3525

Lys Gln Tyr Asn 
1               


<210>  3526
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3526

Lys Gln Tyr Asn Cys 
1               5   


<210>  3527
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3527

Lys Arg Leu Ala 
1               


<210>  3528
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3528

Lys Arg Leu Ala Asn Leu Lys Asp 
1               5               


<210>  3529
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3529

Lys Arg Gln Gly Arg 
1               5   


<210>  3530
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3530

Lys Thr Leu Ala Gln Tyr Thr 
1               5           


<210>  3531
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3531

Lys Thr Tyr Leu Ser Lys Thr 
1               5           


<210>  3532
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3532

Lys Val Glu Gly Gln Ile 
1               5       


<210>  3533
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3533

Lys Tyr Gln Asp Ile Ile Leu Glu 
1               5               


<210>  3534
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3534

Leu Ala Phe Gly Lys Arg 
1               5       


<210>  3535
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3535

Leu Ala Phe Pro Lys Ile Thr 
1               5           


<210>  3536
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3536

Leu Ala Asn Gly Arg 
1               5   


<210>  3537
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3537

Leu Ala Asn Gly Arg Val 
1               5       


<210>  3538
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3538

Leu Ala Asn Gly Arg Val Ile Glu 
1               5               


<210>  3539
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3539

Leu Ala Asn Leu Lys Asp 
1               5       


<210>  3540
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3540

Leu Ala Gln Tyr 
1               


<210>  3541
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3541

Leu Ala Tyr Glu 
1               


<210>  3542
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3542

Leu Asp Phe Tyr Ser Ile His Val Thr 
1               5                   


<210>  3543
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3543

Leu Glu Gln Ile 
1               


<210>  3544
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3544

Leu Glu Gln Ile Gly 
1               5   


<210>  3545
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3545

Leu Glu Thr Gly Ser Leu Lys 
1               5           


<210>  3546
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3546

Leu Phe Leu Arg 
1               


<210>  3547
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3547

Leu Gly Lys Phe Gly Gln Arg 
1               5           


<210>  3548
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3548

Leu Gly Lys Phe Gly Gln Arg Ala 
1               5               


<210>  3549
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3549

Leu Gly Asn Pro Thr 
1               5   


<210>  3550
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3550

Leu Gly Asn Pro Thr His Ile 
1               5           


<210>  3551
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3551

Leu His Leu Glu 
1               


<210>  3552
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3552

Leu His Leu Glu Lys 
1               5   


<210>  3553
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3553

Leu His Leu Glu Lys Lys His 
1               5           


<210>  3554
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3554

Leu Ile Asn Glu Lys Lys Glu 
1               5           


<210>  3555
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3555

Leu Lys Glu Ala Asp 
1               5   


<210>  3556
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3556

Leu Lys Glu Ala Asp Lys Asp 
1               5           


<210>  3557
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3557

Leu Lys Gly Phe Pro 
1               5   


<210>  3558
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3558

Leu Lys Val Glu Gly Gln Ile 
1               5           


<210>  3559
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3559

Leu Leu Pro Tyr 
1               


<210>  3560
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3560

Leu Leu Ser Pro His 
1               5   


<210>  3561
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3561

Leu Leu Ser Pro His Lys 
1               5       


<210>  3562
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3562

Leu Leu Tyr Tyr 
1               


<210>  3563
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3563

Leu Asn Leu Tyr 
1               


<210>  3564
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3564

Leu Asn Leu Tyr Leu 
1               5   


<210>  3565
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3565

Leu Asn Leu Tyr Leu Ile 
1               5       


<210>  3566
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3566

Leu Pro Leu Ala 
1               


<210>  3567
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3567

Leu Pro Pro Gln 
1               


<210>  3568
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3568

Leu Pro Ser Lys Thr Tyr 
1               5       


<210>  3569
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3569

Leu Pro Tyr Leu Ser Ser Glu 
1               5           


<210>  3570
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3570

Leu Arg Ser Pro Cys Leu 
1               5       


<210>  3571
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3571

Leu Ser Asp Ala Cys Met Gly 
1               5           


<210>  3572
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3572

Leu Ser Glu Glu 
1               


<210>  3573
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3573

Leu Ser Glu Glu Ser Val Asn 
1               5           


<210>  3574
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3574

Leu Ser Lys Thr Leu Ala 
1               5       


<210>  3575
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3575

Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
1               5                   


<210>  3576
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3576

Leu Ser Leu Glu Thr Gly Ser 
1               5           


<210>  3577
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3577

Leu Ser Arg Phe Lys Asp 
1               5       


<210>  3578
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3578

Leu Ser Arg Phe Lys Asp Ser 
1               5           


<210>  3579
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3579

Leu Ser Val Glu Leu Asp Arg 
1               5           


<210>  3580
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3580

Leu Thr Ala Lys Leu Ala 
1               5       


<210>  3581
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3581

Leu Thr Lys Tyr 
1               


<210>  3582
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3582

Leu Trp Pro Arg Gly Ser Thr 
1               5           


<210>  3583
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3583

Leu Trp Gln Lys Leu Lys 
1               5       


<210>  3584
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3584

Met Ala Glu Arg Gln Tyr 
1               5       


<210>  3585
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3585

Met Val Arg Asn 
1               


<210>  3586
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3586

Met Val Arg Asn Thr Ala Arg 
1               5           


<210>  3587
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3587

Asn Cys Ala Phe 
1               


<210>  3588
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3588

Asn Cys Ala Phe Ile Trp 
1               5       


<210>  3589
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3589

Asn Cys Ala Phe Ile Trp Gln Lys 
1               5               


<210>  3590
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3590

Asn Asp Ile Ser Ser Trp Thr 
1               5           


<210>  3591
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3591

Asn Glu Lys Arg Leu Ala 
1               5       


<210>  3592
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3592

Asn Gly Leu Ala Phe Pro Lys 
1               5           


<210>  3593
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3593

Asn Ile Ala Arg 
1               


<210>  3594
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3594

Asn Leu Ser Arg 
1               


<210>  3595
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3595

Asn Pro Thr His Ile Leu Arg 
1               5           


<210>  3596
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3596

Asn Arg Phe Tyr Thr Val Ile 
1               5           


<210>  3597
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3597

Asn Arg Tyr Lys Arg Gln 
1               5       


<210>  3598
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3598

Asn Ser Ile Leu Asp 
1               5   


<210>  3599
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3599

Asn Ser Ser Leu 
1               


<210>  3600
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3600

Asn Ser Ser Leu 
1               


<210>  3601
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3601

Asn Ser Ser Leu Ser Ala 
1               5       


<210>  3602
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3602

Asn Ser Ser Leu Ser Ala Ser Phe 
1               5               


<210>  3603
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3603

Asn Ser Ser Leu Ser Ala Ser Phe 
1               5               


<210>  3604
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3604

Asn Thr Asp Lys 
1               


<210>  3605
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3605

Asn Val Lys Lys Leu Ile Asn 
1               5           


<210>  3606
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3606

Asn Val Ser Glu His Glu Arg 
1               5           


<210>  3607
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3607

Asn Val Val Ala Gln 
1               5   


<210>  3608
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3608

Asn Val Val Ala Gln Ile 
1               5       


<210>  3609
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3609

Asn Tyr Phe Lys 
1               


<210>  3610
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3610

Pro Ala Leu Phe 
1               


<210>  3611
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3611

Pro Ala Val Ile Ala Leu 
1               5       


<210>  3612
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3612

Pro Ala Val Ile Ala Leu Thr 
1               5           


<210>  3613
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3613

Pro Cys Thr Thr Gly Glu Pro Asp 
1               5               


<210>  3614
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3614

Pro Glu Ala Phe Glu 
1               5   


<210>  3615
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3615

Pro Glu Ala Phe Glu Ala Asn 
1               5           


<210>  3616
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3616

Pro Glu Ala Asn Asp Glu 
1               5       


<210>  3617
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3617

Pro His Thr Lys 
1               


<210>  3618
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3618

Pro His Thr Lys Glu 
1               5   


<210>  3619
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3619

Pro Met Asn Leu 
1               


<210>  3620
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3620

Pro Met Asn Leu Ile 
1               5   


<210>  3621
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3621

Pro Pro Leu Leu 
1               


<210>  3622
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3622

Pro Arg Leu Tyr 
1               


<210>  3623
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3623

Pro Ser Lys Thr Tyr 
1               5   


<210>  3624
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3624

Pro Ser Thr Ala 
1               


<210>  3625
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3625

Pro Thr His Ile 
1               


<210>  3626
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3626

Pro Thr His Ile Leu 
1               5   


<210>  3627
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3627

Pro Thr His Ile Leu Arg 
1               5       


<210>  3628
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3628

Pro Thr His Ile Leu Arg Ile 
1               5           


<210>  3629
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3629

Pro Thr Arg Asp 
1               


<210>  3630
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3630

Pro Val Lys Pro Leu Glu 
1               5       


<210>  3631
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3631

Gln Ala Ala Leu Asn 
1               5   


<210>  3632
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3632

Gln Asp Ala Met Leu Ile 
1               5       


<210>  3633
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3633

Gln Asp Glu Pro Ala Leu Phe 
1               5           


<210>  3634
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3634

Gln Gly Lys Arg Thr Phe Met 
1               5           


<210>  3635
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3635

Gln Gly Arg Glu 
1               


<210>  3636
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3636

Gln Gly Arg Glu Phe Ile 
1               5       


<210>  3637
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3637

Gln Gly Arg Glu Phe Ile Trp Asn 
1               5               


<210>  3638
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3638

Gln Ile Gly Gly Asn 
1               5   


<210>  3639
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3639

Gln Ile Gly Gly Asn Ser 
1               5       


<210>  3640
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3640

Gln Ile Thr Tyr Tyr Asn 
1               5       


<210>  3641
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3641

Gln Lys Asp Gly Val Lys 
1               5       


<210>  3642
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3642

Gln Lys Val Ile Lys 
1               5   


<210>  3643
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3643

Gln Asn Val Val Lys 
1               5   


<210>  3644
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3644

Gln Asn Val Val Lys Asp 
1               5       


<210>  3645
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3645

Gln Arg Ala Leu Asp 
1               5   


<210>  3646
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3646

Gln Arg Ala Leu Asp Phe Tyr 
1               5           


<210>  3647
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3647

Gln Arg Ala Leu Asp Phe Tyr Ser 
1               5               


<210>  3648
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3648

Gln Arg Leu Lys 
1               


<210>  3649
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3649

Gln Arg Thr Ile 
1               


<210>  3650
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3650

Gln Arg Thr Ile Gln Ala 
1               5       


<210>  3651
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3651

Gln Ser Phe Tyr Arg Lys Lys 
1               5           


<210>  3652
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3652

Gln Thr Asn Lys 
1               


<210>  3653
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3653

Gln Thr Asn Lys Thr 
1               5   


<210>  3654
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3654

Gln Thr Asn Lys Thr Thr Gly 
1               5           


<210>  3655
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3655

Gln Tyr Thr Ser Lys Thr 
1               5       


<210>  3656
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3656

Arg Ala Lys Ala Ser 
1               5   


<210>  3657
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3657

Arg Ala Ser Leu Ala 
1               5   


<210>  3658
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3658

Arg Cys Asn Val 
1               


<210>  3659
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3659

Arg Cys Asn Val Ser 
1               5   


<210>  3660
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3660

Arg Cys Asn Val Ser Glu 
1               5       


<210>  3661
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3661

Arg Cys Asn Val Ser Glu His Glu 
1               5               


<210>  3662
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3662

Arg Glu Phe Ile Trp 
1               5   


<210>  3663
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3663

Arg Glu Phe Ile Trp Asn Asp Leu Leu 
1               5                   


<210>  3664
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3664

Arg Glu Ser Asn His 
1               5   


<210>  3665
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3665

Arg Phe Tyr Thr 
1               


<210>  3666
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3666

Arg Phe Tyr Thr Val 
1               5   


<210>  3667
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3667

Arg Phe Tyr Thr Val Ile Asn Lys Lys 
1               5                   


<210>  3668
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3668

Arg Gly Arg Pro Ile 
1               5   


<210>  3669
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3669

Arg Lys Tyr Ala 
1               


<210>  3670
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3670

Arg Asn Arg Ser Ala 
1               5   


<210>  3671
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3671

Arg Asn Arg Ser Ala Ala 
1               5       


<210>  3672
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3672

Arg Asn Thr Ala Arg Asp 
1               5       


<210>  3673
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3673

Arg Asn Thr Ala Arg Asp Leu Leu Tyr 
1               5                   


<210>  3674
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3674

Arg Pro Gly Arg Glu Ser Thr Arg Arg Trp 
1               5                   10  


<210>  3675
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3675

Arg Pro Ser Arg 
1               


<210>  3676
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3676

Arg Gln Ala Asn Glu Val Asp 
1               5           


<210>  3677
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3677

Arg Gln Gly Lys 
1               


<210>  3678
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3678

Arg Gln Gly Arg Glu 
1               5   


<210>  3679
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3679

Arg Gln Asn Val Val Lys Asp Leu 
1               5               


<210>  3680
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3680

Arg Gln Tyr Thr 
1               


<210>  3681
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3681

Arg Arg Thr Arg 
1               


<210>  3682
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3682

Arg Arg Thr Arg Gln 
1               5   


<210>  3683
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3683

Arg Arg Thr Arg Gln Asp 
1               5       


<210>  3684
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3684

Arg Arg Thr Arg Gln Asp Glu 
1               5           


<210>  3685
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3685

Arg Ser Gly Glu Ala 
1               5   


<210>  3686
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3686

Arg Ser Gln Glu Tyr Lys 
1               5       


<210>  3687
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3687

Arg Ser Thr Ala Arg 
1               5   


<210>  3688
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3688

Arg Ser Thr Ala Arg Thr Gly Ala 
1               5               


<210>  3689
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3689

Arg Ser Trp Leu Phe Leu 
1               5       


<210>  3690
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3690

Arg Thr Ala Thr Gln Arg Arg 
1               5           


<210>  3691
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3691

Arg Thr Phe Met 
1               


<210>  3692
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3692

Arg Thr Phe Met Ala Glu 
1               5       


<210>  3693
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3693

Arg Thr Ile Gln Ala Ala Lys 
1               5           


<210>  3694
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3694

Arg Thr Ser Thr Ala Ser Thr 
1               5           


<210>  3695
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3695

Ser Glu Glu Asp Arg 
1               5   


<210>  3696
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3696

Ser Phe Ser Ser His 
1               5   


<210>  3697
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3697

Ser Phe Val Ile 
1               


<210>  3698
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3698

Ser Phe Val Ile Glu 
1               5   


<210>  3699
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3699

Ser Phe Val Ile Glu Gly Leu Lys 
1               5               


<210>  3700
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3700

Ser Phe Tyr Arg 
1               


<210>  3701
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3701

Ser Gly Cys Val 
1               


<210>  3702
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3702

Ser Gly Glu Ile 
1               


<210>  3703
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3703

Ser Gly Glu Ile Val 
1               5   


<210>  3704
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3704

Ser His Cys Arg Asp 
1               5   


<210>  3705
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3705

Ser His Leu Gln 
1               


<210>  3706
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3706

Ser His Leu Gln Asn Ser 
1               5       


<210>  3707
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3707

Ser His Arg Pro Val Gln Glu 
1               5           


<210>  3708
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3708

Ser His Thr Ala 
1               


<210>  3709
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3709

Ser His Thr Ala Trp Ala Ser Ser Asp 
1               5                   


<210>  3710
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3710

Ser Ile His Val Thr Arg Glu 
1               5           


<210>  3711
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3711

Ser Lys Gln Tyr 
1               


<210>  3712
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3712

Ser Lys Gln Tyr Asn 
1               5   


<210>  3713
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3713

Ser Lys Thr Leu Ala Gln 
1               5       


<210>  3714
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3714

Ser Lys Thr Leu Ala Gln Tyr Thr 
1               5               


<210>  3715
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3715

Ser Lys Thr Tyr Leu 
1               5   


<210>  3716
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3716

Ser Leu Gly Lys Phe Gly 
1               5       


<210>  3717
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3717

Ser Leu Gly Lys Phe Gly Gln 
1               5           


<210>  3718
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3718

Ser Leu Lys Leu Ala 
1               5   


<210>  3719
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3719

Ser Leu Leu Lys 
1               


<210>  3720
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3720

Ser Leu Leu Lys Lys 
1               5   


<210>  3721
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3721

Ser Leu Leu Lys Lys Arg 
1               5       


<210>  3722
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3722

Ser Leu Leu Lys Lys Arg Phe Ser 
1               5               


<210>  3723
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3723

Ser Asn His Pro 
1               


<210>  3724
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3724

Ser Asn His Pro Val Lys Pro 
1               5           


<210>  3725
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3725

Ser Asn Ile Lys 
1               


<210>  3726
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3726

Ser Pro Ala Arg 
1               


<210>  3727
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3727

Ser Pro Glu Arg Arg 
1               5   


<210>  3728
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3728

Ser Arg Phe Lys Asp 
1               5   


<210>  3729
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3729

Ser Arg Thr Ala Thr Gln Arg 
1               5           


<210>  3730
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3730

Ser Ser Ser Leu 
1               


<210>  3731
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3731

Ser Ser Ser Leu Ala Ser Gly Leu 
1               5               


<210>  3732
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3732

Ser Val Asn Asn 
1               


<210>  3733
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3733

Ser Val Asn Asn Asp Ile 
1               5       


<210>  3734
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3734

Ser Val Ser Ser Lys 
1               5   


<210>  3735
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3735

Ser Trp Leu Phe Leu 
1               5   


<210>  3736
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3736

Thr Ala Lys Leu Ala Tyr 
1               5       


<210>  3737
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3737

Thr Ala Lys Leu Ala Tyr Glu Gly 
1               5               


<210>  3738
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3738

Thr Cys Ser Asn 
1               


<210>  3739
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3739

Thr Cys Ser Asn Cys Gly 
1               5       


<210>  3740
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3740

Thr Cys Ser Asn Cys Gly Phe Thr 
1               5               


<210>  3741
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3741

Thr Asp Lys Arg Ala Phe Val Glu 
1               5               


<210>  3742
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3742

Thr Asp Pro Glu Gly 
1               5   


<210>  3743
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3743

Thr Asp Pro Glu Gly Cys Pro 
1               5           


<210>  3744
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3744

Thr Phe Glu Arg 
1               


<210>  3745
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3745

Thr Phe Glu Arg Arg Glu 
1               5       


<210>  3746
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3746

Thr Phe Glu Arg Arg Glu Val 
1               5           


<210>  3747
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3747

Thr His Ala Ala Glu Gln 
1               5       


<210>  3748
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3748

Thr His Ala Ala Glu Gln Ala 
1               5           


<210>  3749
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3749

Thr His Ala Ala Glu Gln Ala Ala 
1               5               


<210>  3750
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3750

Thr Ile Gln Ala 
1               


<210>  3751
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3751

Thr Lys Tyr Gln 
1               


<210>  3752
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3752

Thr Lys Tyr Gln Asp 
1               5   


<210>  3753
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3753

Thr Leu Ala Gln Tyr Thr 
1               5       


<210>  3754
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3754

Thr Leu Pro Pro Gln 
1               5   


<210>  3755
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3755

Thr Leu Pro Pro Gln Pro His 
1               5           


<210>  3756
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3756

Thr Asn Tyr Phe Gly 
1               5   


<210>  3757
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3757

Thr Asn Tyr Phe Gly Arg Cys Asn 
1               5               


<210>  3758
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3758

Thr Pro Thr Thr Ser Ala Asp Ala Thr Cys 
1               5                   10  


<210>  3759
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3759

Thr Arg Met Glu 
1               


<210>  3760
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3760

Thr Ser Lys Thr Cys 
1               5   


<210>  3761
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3761

Thr Thr Ile Asn 
1               


<210>  3762
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3762

Thr Thr Ile Asn Gly 
1               5   


<210>  3763
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3763

Thr Thr Ile Asn Gly Lys Glu 
1               5           


<210>  3764
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3764

Val Ala Lys Pro Leu Leu Gln Gln 
1               5               


<210>  3765
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3765

Val Ala Gln Ile 
1               


<210>  3766
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3766

Val Ala Ser Phe Leu 
1               5   


<210>  3767
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3767

Val Ala Ser Phe Leu Thr 
1               5       


<210>  3768
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3768

Val Cys Leu Asn 
1               


<210>  3769
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3769

Val Cys Leu Asn Cys 
1               5   


<210>  3770
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3770

Val Cys Asn Val Lys Lys 
1               5       


<210>  3771
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3771

Val Cys Asn Val Lys Lys Leu Ile 
1               5               


<210>  3772
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3772

Val Asp Trp Trp Asp 
1               5   


<210>  3773
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3773

Val Glu Gly Gln 
1               


<210>  3774
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3774

Val Glu Gly Gln Ile Thr 
1               5       


<210>  3775
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3775

Val Glu Gln Arg 
1               


<210>  3776
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3776

Val Glu Gln Arg Arg 
1               5   


<210>  3777
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3777

Val Glu Arg Gln Ala Asn Glu 
1               5           


<210>  3778
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3778

Val Ile Glu Lys 
1               


<210>  3779
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3779

Val Ile Glu Lys Thr Leu Tyr 
1               5           


<210>  3780
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3780

Val Ile Glu Lys Thr Leu Tyr Asn 
1               5               


<210>  3781
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3781

Val Lys Asp Leu Ser 
1               5   


<210>  3782
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3782

Val Lys Lys Leu Asn 
1               5   


<210>  3783
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3783

Val Lys Pro Leu Glu 
1               5   


<210>  3784
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3784

Val Lys Pro Leu Glu Gln Ile 
1               5           


<210>  3785
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3785

Val Leu Asp Ser Ser Asn Ile Lys 
1               5               


<210>  3786
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3786

Val Leu Glu Lys 
1               


<210>  3787
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3787

Val Pro Ser Lys 
1               


<210>  3788
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3788

Val Ser Cys Lys 
1               


<210>  3789
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3789

Val Ser Glu His Glu 
1               5   


<210>  3790
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3790

Val Ser Glu His Glu Arg Leu 
1               5           


<210>  3791
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3791

Val Ser Glu His Glu Arg Leu Ile 
1               5               


<210>  3792
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3792

Val Ser Ile Lys 
1               


<210>  3793
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3793

Val Ser Ile Lys Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3794
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3794

Val Ser Arg Lys 
1               


<210>  3795
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3795

Val Ser Ser Glu 
1               


<210>  3796
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3796

Val Ser Ser Glu Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3797
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3797

Val Ser Ser Lys 
1               


<210>  3798
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3798

Val Ser Ser Lys Ala 
1               5   


<210>  3799
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3799

Val Ser Ser Lys Asp 
1               5   


<210>  3800
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3800

Val Ser Ser Lys Asp 
1               5   


<210>  3801
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3801

Val Ser Ser Lys Asp Phe Gln 
1               5           


<210>  3802
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3802

Val Ser Ser Lys Asp His 
1               5       


<210>  3803
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3803

Val Ser Ser Lys Asp Ile 
1               5       


<210>  3804
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3804

Val Ser Ser Lys Asp Leu 
1               5       


<210>  3805
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3805

Val Ser Ser Lys Asp Leu Glu 
1               5           


<210>  3806
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3806

Val Ser Ser Lys Asp Leu His 
1               5           


<210>  3807
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3807

Val Ser Ser Lys Asp Leu His Ala Ser Asn 
1               5                   10  


<210>  3808
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3808

Val Ser Ser Lys Asp Leu Lys 
1               5           


<210>  3809
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3809

Val Ser Ser Lys Asp Leu Gln 
1               5           


<210>  3810
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3810

Val Ser Ser Lys Asp Leu Gln Ala 
1               5               


<210>  3811
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3811

Val Ser Ser Lys Asp Leu Gln Ala Cys Leu 
1               5                   10  


<210>  3812
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3812

Val Ser Ser Lys Asp Leu Gln Ala Ser 
1               5                   


<210>  3813
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3813

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn 
1               5                   10  


<210>  3814
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3814

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3815
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3815

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn Asn 
1               5                   10      


<210>  3816
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3816

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn Thr 
1               5                   10      


<210>  3817
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3817

Val Ser Ser Lys Asp Leu Gln Glu 
1               5               


<210>  3818
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3818

Val Ser Ser Lys Asp Leu Gln Gly 
1               5               


<210>  3819
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3819

Val Ser Ser Lys Asp Leu Arg 
1               5           


<210>  3820
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3820

Val Ser Ser Lys Asp Leu Arg Ala 
1               5               


<210>  3821
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3821

Val Ser Ser Lys Asp Leu Val 
1               5           


<210>  3822
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3822

Val Ser Ser Lys Asp Pro 
1               5       


<210>  3823
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3823

Val Ser Ser Lys Asp Gln 
1               5       


<210>  3824
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3824

Val Ser Ser Lys Asp Val 
1               5       


<210>  3825
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3825

Val Ser Ser Lys Asp Val Gln 
1               5           


<210>  3826
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3826

Val Ser Ser Lys Glu 
1               5   


<210>  3827
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3827

Val Ser Ser Lys Val Leu Gln 
1               5           


<210>  3828
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3828

Val Ser Ser Lys Tyr Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3829
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3829

Val Ser Ser Asn 
1               


<210>  3830
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3830

Val Ser Ser Asn Asp 
1               5   


<210>  3831
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3831

Val Ser Ser Asn Asp Leu Gln 
1               5           


<210>  3832
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3832

Val Ser Ser Asn Asp Leu Gln Ala Ser Asn 
1               5                   10  


<210>  3833
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3833

Val Ser Ser Asn Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3834
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3834

Val Ser Ser Arg 
1               


<210>  3835
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3835

Val Val Ala Gln 
1               


<210>  3836
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3836

Val Val Ala Gln Ile 
1               5   


<210>  3837
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3837

Val Val Lys Asp Leu Ser Val Glu 
1               5               


<210>  3838
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3838

Val Trp Lys Pro Ala 
1               5   


<210>  3839
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3839

Val Trp Lys Pro Ala Val 
1               5       


<210>  3840
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3840

Trp Gly Lys Val Tyr Asp Glu Ala 
1               5               


<210>  3841
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3841

Trp Leu Phe Leu 
1               


<210>  3842
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3842

Trp Asn Asp Leu Leu 
1               5   


<210>  3843
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3843

Trp Pro Arg Ser 
1               


<210>  3844
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3844

Trp Thr Lys Gly Arg 
1               5   


<210>  3845
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3845

Trp Val Asn Leu Asn 
1               5   


<210>  3846
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3846

Trp Trp Asp Met Val 
1               5   


<210>  3847
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3847

Tyr Asp Glu Ala Trp Glu 
1               5       


<210>  3848
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3848

Tyr Glu Gly Leu Pro Ser 
1               5       


<210>  3849
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3849

Tyr Gly Asp Leu Arg 
1               5   


<210>  3850
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3850

Tyr Lys Lys Tyr Gln 
1               5   


<210>  3851
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3851

Tyr Leu Ile Ile Asn 
1               5   


<210>  3852
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3852

Tyr Leu Ser Lys Thr Leu Ala 
1               5           


<210>  3853
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3853

Tyr Asn Arg Arg Thr Arg 
1               5       


<210>  3854
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3854

Tyr Asn Arg Tyr Lys 
1               5   


<210>  3855
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3855

Tyr Gln Phe Gly 
1               


<210>  3856
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3856

Tyr Gln Thr Asn 
1               


<210>  3857
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3857

Tyr Thr Arg Met 
1               


<210>  3858
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3858

Tyr Thr Arg Met Glu 
1               5   


<210>  3859
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3859

Tyr Thr Arg Met Glu Asp 
1               5       


<210>  3860
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3860

Tyr Thr Ser Lys 
1               


<210>  3861
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3861

Tyr Thr Val Ile Asn Lys Lys 
1               5           


<210>  3862
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3862

Tyr Val Ser Ser Lys Asp Leu 
1               5           


<210>  3863
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3863

Tyr Val Ser Ser Lys Asp Leu Gln 
1               5               


<210>  3864
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3864

Tyr Val Ser Ser Lys Asp Leu Gln Ala 
1               5                   


<210>  3865
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DME variant alteration

<400>  3865

Tyr Tyr Ala Val Thr Gln 
1               5       


<210>  3866
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3866

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3867
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3867

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3868
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3868

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3869
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3869

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3870
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3870

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3871
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3871

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3872
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3872

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3873
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3873

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3874
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3874

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3875
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3875

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3876
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3876

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3877
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3877

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3878
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3878

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3879
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3879

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3880
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3880

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3881
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3881

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3882
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3882

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3883
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3883

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3884
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3884

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3885
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3885

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3886
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3886

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3887
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3887

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3888
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3888

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3889
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3889

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3890
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3890

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3891
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3891

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3892
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3892

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Arg Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3893
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3893

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3894
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3894

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3895
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3895

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Ala Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3896
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3896

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3897
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3897

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3898
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3898

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Gly Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3899
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3899

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3900
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3900

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Lys Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3901
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3901

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3902
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3902

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Ala Ser Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3903
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3903

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe His Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3904
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3904

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3905
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3905

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Trp Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3906
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3906

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3907
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3907

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3908
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3908

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Met Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3909
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3909

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3910
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3910

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3911
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3911

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Gln Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3912
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3912

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Lys Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3913
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3913

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3914
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3914

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Gln Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3915
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3915

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Ala Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3916
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3916

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3917
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3917

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3918
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3918

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3919
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3919

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Thr Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3920
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3920

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Gln Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3921
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3921

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3922
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3922

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3923
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3923

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Ser Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3924
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3924

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Lys Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3925
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3925

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3926
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3926

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3927
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3927

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Arg Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3928
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3928

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3929
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3929

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Arg Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3930
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3930

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Glu 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3931
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3931

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3932
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3932

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Lys Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3933
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3933

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile His Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3934
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3934

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3935
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3935

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Arg Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3936
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3936

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Lys Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3937
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3937

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Arg Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3938
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3938

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Arg Pro 
                965                 970                 975     


Ala Val 
        


<210>  3939
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3939

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Met Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3940
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3940

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3941
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3941

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Ser Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3942
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3942

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Thr Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3943
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3943

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Gln Pro 
                965                 970                 975     


Ala Val 
        


<210>  3944
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3944

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Arg Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3945
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3945

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3946
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3946

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Trp Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3947
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3947

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3948
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3948

Met Gln Glu Ile Lys Arg Phe Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3949
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3949

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Lys Ile Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3950
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3950

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Glu Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3951
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3951

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Ala Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3952
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3952

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3953
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3953

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Gln Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3954
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3954

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3955
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3955

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Lys Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3956
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3956

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Arg Lys Thr Leu Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3957
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3957

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3958
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3958

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Lys Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3959
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3959

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Pro Ser Lys Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3960
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3960

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Gly Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3961
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3961

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Leu Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3962
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3962

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Lys Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3963
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3963

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Arg Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3964
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3964

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Lys Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3965
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3965

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Arg Lys Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3966
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3966

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Gln Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3967
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3967

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asn Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3968
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3968

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Arg Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3969
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3969

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile His Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3970
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3970

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Lys Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3971
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3971

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Glu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3972
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3972

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Arg Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3973
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3973

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro Asp Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3974
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3974

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Gly Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3975
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3975

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Pro Pro Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3976
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3976

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Phe Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3977
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3977

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Met Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3978
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3978

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Arg Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3979
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3979

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Arg Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3980
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3980

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Gly Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3981
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3981

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3982
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3982

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Gly 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3983
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3983

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Glu Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3984
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3984

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Lys Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3985
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3985

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Gln Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3986
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3986

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Phe Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3987
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3987

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Gln Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3988
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3988

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Lys Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3989
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3989

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Ala Ser Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3990
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3990

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Glu Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3991
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3991

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Ala Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3992
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3992

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Glu Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3993
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3993

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Gln Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3994
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3994

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Ala Ser Lys Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3995
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3995

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Gln Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3996
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3996

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Lys Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3997
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3997

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Ile Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3998
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3998

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asp 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3999
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  3999

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4000
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4000

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Ser Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4001
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4001

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Lys Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ser Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4002
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4002

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Ile Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4003
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4003

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Gln Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4004
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4004

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asp Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4005
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4005

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Met Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4006
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4006

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Asp Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4007
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4007

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Leu Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4008
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4008

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  4009
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4009

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Ser Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4010
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4010

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Trp Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4011
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4011

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ser Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4012
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4012

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Arg Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4013
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4013

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Lys Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4014
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4014

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Ala Ser Lys Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  4015
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4015

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Tyr Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4016
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4016

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Arg Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4017
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4017

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Asp Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4018
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4018

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Glu 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4019
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4019

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Ile Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4020
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4020

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Arg Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4021
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4021

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Pro Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4022
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4022

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Leu Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  4023
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4023

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Asp Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4024
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4024

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Lys 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4025
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4025

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Arg Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4026
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4026

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Lys 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4027
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4027

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Val Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4028
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4028

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Glu Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4029
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4029

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Thr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4030
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4030

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Ser Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4031
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4031

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Glu Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4032
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4032

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Thr Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4033
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4033

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asn Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4034
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4034

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Phe His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4035
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4035

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Ser Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4036
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4036

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Ala Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  4037
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4037

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Asn Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4038
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4038

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Arg Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4039
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4039

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Pro Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4040
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4040

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Ile Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4041
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4041

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Thr Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  4042
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4042

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Gly Arg Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4043
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4043

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Asn Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4044
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4044

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Pro Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  4045
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4045

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Arg Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4046
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4046

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Gly Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4047
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4047

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Met Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  4048
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4048

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys Arg Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4049
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4049

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ser Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4050
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4050

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Lys 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4051
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4051

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Asn Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4052
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4052

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu Arg Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4053
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4053

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Ile Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Ala Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Asp Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ser Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Pro Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4054
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4054

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile His Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4055
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4055

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Val Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4056
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4056

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Asp Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4057
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4057

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Ala Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4058
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Protein Variant

<400>  4058

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Pro Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4059
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  beta-2 microglobulin (B2M) 7.37 non-target strand

<400>  4059
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  4060
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  beta-2 microglobulin (B2M) 7.37 target strand

<400>  4060
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  4061
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4061
gaggaggacg gcctggccga                                                   20


<210>  4062
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4062
accgctgcgc caaggtgcgg                                                   20


<210>  4063
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4063
gccaggccgt cctcctcgga                                                   20


<210>  4064
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4064
gtgctcgggt gcttcggcca                                                   20


<210>  4065
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4065
atggccttct tcctggcttc                                                   20


<210>  4066
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4066
gcaccaccac gtaggtgcca                                                   20


<210>  4067
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4067
tcctggcttc ctggtgaaga                                                   20


<210>  4068
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4068
tggcttcctg gtgaagatga                                                   20


<210>  4069
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4069
ccaggaagcc aggaagaagg                                                   20


<210>  4070
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4070
tccttgcatg gggccaggat                                                   20


<210>  4071
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4071
ggcggcaagt tctgctcagc                                                   20


<210>  4072
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4072
tctccacgat cgtcagcgtg                                                   20


<210>  4073
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4073
acgatcgtca gcgtgagtgc                                                   20


<210>  4074
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4074
ctctagcaat ggatcgtggg                                                   20


<210>  4075
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4075
caaacaaatg tgtcacaaag                                                   20


<210>  4076
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4076
gatgtgtata tcacagacaa                                                   20


<210>  4077
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4077
ggaataatgc tgttgttgaa                                                   20


<210>  4078
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4078
aaatccagtg acaagtctgt                                                   20


<210>  4079
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4079
aggccacagc actgttgctc                                                   20


<210>  4080
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4080
agaagacacc ttcttcccca                                                   20


<210>  4081
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4081
tccccagccc aggtaagggc                                                   20


<210>  4082
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4082
ccagcccagg taagggcagc                                                   20


<210>  4083
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4083
agtccctcaa gtccttccag                                                   20


<210>  4084
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4084
agcagcagca gcagcagcag                                                   20


<210>  4085
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4085
tcagccgccg ccgcaggcac                                                   20


<210>  4086
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4086
agggtcgcca tggcggtctc                                                   20


<210>  4087
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4087
tcagcttttc cagggtcgcc                                                   20


<210>  4088
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4088
gccgcagccg cccccgccgc                                                   20


<210>  4089
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4089
gccacagccg ggccgggtgg                                                   20


<210>  4090
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4090
tcagccacag ccgggccggg                                                   20


<210>  4091
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4091
cggtcggtgc agcggctcct                                                   20


<210>  4092
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4092
ccacaccttc actggtccat                                                   20


<210>  4093
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4093
taaaggaaag taatggacca                                                   20


<210>  4094
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4094
ctggtccatt actttccttt                                                   20


<210>  4095
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4095
atgttcatga gtttggagat                                                   20


<210>  4096
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4096
tgagtttgga gataatacag                                                   20


<210>  4097
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4097
atagacacat cggccacacc                                                   20


<210>  4098
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4098
ttattaggca tgttggagac                                                   20


<210>  4099
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4099
caggagacca ttgcatcatt                                                   20


<210>  4100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4100
ggcctggagg ctatccagcg                                                   20


<210>  4101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4101
cgctggatag cctccaggcc                                                   20


<210>  4102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  oSH7 PCR primer

<400>  4102
aacacgtccg tcctagaact                                                   20


<210>  4103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  oSH8 PCR primer

<400>  4103
acttggttac gctcaacact                                                   20


<210>  4104
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SAH24 primer

<400>  4104
ttcaggttgg accggtgcca ccatggcccc aaagaagaag cggaaggtca gccaagagat       60

caagagaatc aacaagatca ga                                                82


<210>  4105
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SAH25 primer

<400>  4105
ttttggacta gtcacggcgg gcttccag                                          28


<210>  4106
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  oIC539 primer

<400>  4106
atggccccaa agaagaagcg gaaggtctct agacaag                                37


<210>  4107
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  oIC540 primer

<400>  4107
tacctttctc ttcttttttg gactagtcac gg                                     32


<210>  4108
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR1 Fwd


<220>
<221>  misc_feature
<222>  (34)..(40)
<223>  n is any nucleotide

<400>  4108
acactctttc cctacacgac gctcttccga tctnnnnnnn                             40


<210>  4109
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2 Rvs

<400>  4109
gtgactggag ttcagacgtg tgctcttccg atct                                   34


<210>  4110
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2 Fwd

<400>  4110
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tc               52


<210>  4111
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_001

<400>  4111
caagcagaag acggcatacg agatcgtgat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4112
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_002

<400>  4112
caagcagaag acggcatacg agatacatcg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4113
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_003

<400>  4113
caagcagaag acggcatacg agatgcctaa gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4114
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_004

<400>  4114
caagcagaag acggcatacg agattggtca gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4115
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_005

<400>  4115
caagcagaag acggcatacg agatcactgt gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4116
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_006

<400>  4116
caagcagaag acggcatacg agatattggc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4117
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_007

<400>  4117
caagcagaag acggcatacg agatgatctg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4118
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_008

<400>  4118
caagcagaag acggcatacg agattcaagt gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4119
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_009

<400>  4119
caagcagaag acggcatacg agatctgatc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4120
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_010

<400>  4120
caagcagaag acggcatacg agataagcta gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4121
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_011

<400>  4121
caagcagaag acggcatacg agatgtagcc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4122
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_012

<400>  4122
caagcagaag acggcatacg agattacaag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4123
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_013

<400>  4123
caagcagaag acggcatacg agatttgact gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4124
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_014

<400>  4124
caagcagaag acggcatacg agatggaact gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4125
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_015

<400>  4125
caagcagaag acggcatacg agattgacat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4126
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_016

<400>  4126
caagcagaag acggcatacg agatggacgg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4127
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_017

<400>  4127
caagcagaag acggcatacg agatctctac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4128
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_018

<400>  4128
caagcagaag acggcatacg agatgcggac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4129
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_019

<400>  4129
caagcagaag acggcatacg agattttcac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4130
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_020

<400>  4130
caagcagaag acggcatacg agatggccac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4131
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_021

<400>  4131
caagcagaag acggcatacg agatcgaaac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4132
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_022

<400>  4132
caagcagaag acggcatacg agatcgtacg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4133
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_023

<400>  4133
caagcagaag acggcatacg agatccactc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4134
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_024

<400>  4134
caagcagaag acggcatacg agatgctacc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4135
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_025

<400>  4135
caagcagaag acggcatacg agatatcagt gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4136
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_026

<400>  4136
caagcagaag acggcatacg agatgctcat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4137
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_027

<400>  4137
caagcagaag acggcatacg agataggaat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4138
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_028

<400>  4138
caagcagaag acggcatacg agatcttttg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4139
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_029

<400>  4139
caagcagaag acggcatacg agattagttg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4140
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_030

<400>  4140
caagcagaag acggcatacg agatccggtg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4141
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_031

<400>  4141
caagcagaag acggcatacg agatatcgtg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4142
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_032

<400>  4142
caagcagaag acggcatacg agattgagtg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4143
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_033

<400>  4143
caagcagaag acggcatacg agatcgcctg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4144
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_034

<400>  4144
caagcagaag acggcatacg agatgccatg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4145
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_035

<400>  4145
caagcagaag acggcatacg agataaaatg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4146
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_036

<400>  4146
caagcagaag acggcatacg agattgttgg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4147
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_037

<400>  4147
caagcagaag acggcatacg agatattccg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4148
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_038

<400>  4148
caagcagaag acggcatacg agatagctag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4149
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_039

<400>  4149
caagcagaag acggcatacg agatgtatag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4150
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_040

<400>  4150
caagcagaag acggcatacg agattctgag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4151
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_041

<400>  4151
caagcagaag acggcatacg agatgtcgtc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4152
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_042

<400>  4152
caagcagaag acggcatacg agatcgatta gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4153
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_043

<400>  4153
caagcagaag acggcatacg agatgctgta gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4154
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_044

<400>  4154
caagcagaag acggcatacg agatattata gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4155
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_045

<400>  4155
caagcagaag acggcatacg agatgaatga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4156
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_046

<400>  4156
caagcagaag acggcatacg agattcggga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4157
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_047

<400>  4157
caagcagaag acggcatacg agatcttcga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4158
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v1_048

<400>  4158
caagcagaag acggcatacg agattgccga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4159
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_001

<400>  4159
caagcagaag acggcatacg agataaccgc gggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4160
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_002

<400>  4160
caagcagaag acggcatacg agatggttat aagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4161
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_003

<400>  4161
caagcagaag acggcatacg agatccaagt ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4162
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_004

<400>  4162
caagcagaag acggcatacg agatttggac ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4163
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_005

<400>  4163
caagcagaag acggcatacg agatcagtgg atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4164
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_006

<400>  4164
caagcagaag acggcatacg agattgacaa gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4165
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_007

<400>  4165
caagcagaag acggcatacg agatctagct tggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4166
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_008

<400>  4166
caagcagaag acggcatacg agattcgatc cagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4167
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_009

<400>  4167
caagcagaag acggcatacg agatcctgaa ctgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4168
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_010

<400>  4168
caagcagaag acggcatacg agatttcagg tcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4169
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_011

<400>  4169
caagcagaag acggcatacg agatagtaga gagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4170
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_012

<400>  4170
caagcagaag acggcatacg agatgacgag aggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4171
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_013

<400>  4171
caagcagaag acggcatacg agatagactt gggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4172
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_014

<400>  4172
caagcagaag acggcatacg agatgagtcc aagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4173
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_015

<400>  4173
caagcagaag acggcatacg agatcttaag ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4174
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_016

<400>  4174
caagcagaag acggcatacg agattccgga ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4175
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_017

<400>  4175
caagcagaag acggcatacg agatctgtat tagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4176
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_018

<400>  4176
caagcagaag acggcatacg agattcacgc cggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4177
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_019

<400>  4177
caagcagaag acggcatacg agatacttac atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4178
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_020

<400>  4178
caagcagaag acggcatacg agatgtccgt gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4179
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_021

<400>  4179
caagcagaag acggcatacg agataaggta ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4180
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_022

<400>  4180
caagcagaag acggcatacg agatggaacg ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4181
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_023

<400>  4181
caagcagaag acggcatacg agataattct gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4182
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_024

<400>  4182
caagcagaag acggcatacg agatggcctc atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4183
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_025

<400>  4183
caagcagaag acggcatacg agatatctta gtgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4184
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_026

<400>  4184
caagcagaag acggcatacg agatgctccg acgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4185
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_027

<400>  4185
caagcagaag acggcatacg agatatacca aggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4186
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_028

<400>  4186
caagcagaag acggcatacg agatgcgttg gagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4187
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_029

<400>  4187
caagcagaag acggcatacg agatcttcac gggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4188
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_030

<400>  4188
caagcagaag acggcatacg agattcctgt aagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4189
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_031

<400>  4189
caagcagaag acggcatacg agatagaatg ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4190
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_032

<400>  4190
caagcagaag acggcatacg agatgaggca ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4191
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_033

<400>  4191
caagcagaag acggcatacg agatcctcgg tagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4192
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_034

<400>  4192
caagcagaag acggcatacg agatttctaa cggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4193
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_035

<400>  4193
caagcagaag acggcatacg agatatgagg ctgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4194
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_036

<400>  4194
caagcagaag acggcatacg agatgcagaa tcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4195
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_037

<400>  4195
caagcagaag acggcatacg agatcactac gagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4196
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_038

<400>  4196
caagcagaag acggcatacg agattgtcgt aggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4197
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_039

<400>  4197
caagcagaag acggcatacg agataccact tagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4198
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_040

<400>  4198
caagcagaag acggcatacg agatgttgtc cggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4199
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_041

<400>  4199
caagcagaag acggcatacg agatatccat atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4200
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_042

<400>  4200
caagcagaag acggcatacg agatgcttgc gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4201
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_043

<400>  4201
caagcagaag acggcatacg agatagtatc ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4202
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_044

<400>  4202
caagcagaag acggcatacg agatgacgct ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4203
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_045

<400>  4203
caagcagaag acggcatacg agatcatgcc atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4204
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_046

<400>  4204
caagcagaag acggcatacg agattgcatt gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4205
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_047

<400>  4205
caagcagaag acggcatacg agatattgga acgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4206
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_Rvs_v2_048

<400>  4206
caagcagaag acggcatacg agatgccaag gtgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4207
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v1_univ

<400>  4207
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  4208
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_univ

<400>  4208
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tc               52


<210>  4209
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_001

<400>  4209
aatgatacgg cgaccaccga gatctacaca gcgctagaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4210
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_002

<400>  4210
aatgatacgg cgaccaccga gatctacacg atatcgaaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4211
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_003

<400>  4211
aatgatacgg cgaccaccga gatctacacc gcagacgaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4212
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_004

<400>  4212
aatgatacgg cgaccaccga gatctacact atgagtaaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4213
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_005

<400>  4213
aatgatacgg cgaccaccga gatctacaca ggtgcgtaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4214
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_006

<400>  4214
aatgatacgg cgaccaccga gatctacacg aacatacaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4215
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_007

<400>  4215
aatgatacgg cgaccaccga gatctacaca catagcgaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4216
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_008

<400>  4216
aatgatacgg cgaccaccga gatctacacg tgcgataaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4217
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_009

<400>  4217
aatgatacgg cgaccaccga gatctacacc caacagaaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4218
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_010

<400>  4218
aatgatacgg cgaccaccga gatctacact tggtgagaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4219
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_011

<400>  4219
aatgatacgg cgaccaccga gatctacacc gcggttcaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4220
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Primer PCR2_fwd_v2_012

<400>  4220
aatgatacgg cgaccaccga gatctacact ataacctaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4221
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Planctomyces reference guide scaffold

<400>  4221
tgacagctag ctcagtccta ggtataatac tagttactgg cgcttttatc tcattacttt       60

gagagccatc accagcgact atgtcgtatg ggtaaagcgc ttatttatcg gagagaaatc      120

cgataaataa gaagcatcaa agctggagtt gtcccaattc ttctagag                   168


<210>  4222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4222
uguggucggg guagcggcug                                                   20


<210>  4223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4223
ucaaguccgc caugcccgaa                                                   20


<210>  4224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4224
auguucauga guuuggagau                                                   20


<210>  4225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  4225
ucgccauaac ucgcuaggcc                                                   20


<210>  4226
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  extended stem region

<400>  4226
gcgcuuacgg acuucggucc guaagaagc                                         29


<210>  4227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  extended stem region

<400>  4227
gcucccucuu cggagggagc                                                   20


<210>  4228
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  extended stem region

<400>  4228
gcucacauga ggaucaccca ugugagc                                           27


<210>  4229
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4229

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4230
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4230

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  4231
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4231

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4232
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4232

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


